WO1998032516A1

WO1998032516A1 - An apparatus for the ultrasonic separation and cleaning of a suspension

Info

Publication number: WO1998032516A1
Application number: PCT/CN1998/000015
Authority: WO
Inventors: Xiaoqing Wang
Original assignee: Beijing Trunk/Cyts Teconology Co. Ltd.
Priority date: 1997-01-24
Filing date: 1998-01-24
Publication date: 1998-07-30
Also published as: CN1243451A; CN1188682A; AU5746998A

Abstract

The present invention relates to an apparatus for the separation of the suspending particles of a liquid such as blood by an ultrasound treatment. The apparatus comprises a first container enclosing an ultrasonic generator, an ultrasonic driver and a second container filled with a liquid containing the suspending particles. The second container is sited between the reflecting wall and the ultrasonic generator in the first container. The space between the first and the second container is filled with a liquid for delivering ultrasonic waves. There is at least one aperture at the bottom of the second container. There are compartments partitioned by some baffles along the circuit of the second container. The compartments are in communication with each other at the top and the bottom of the second container.

Description

TECHNICAL FIELD

The present invention relates to a device for ultrasonically separating suspended particles in a liquid, especially particles such as blood cells; the present invention also relates to a separation system capable of continuously or quasi-continuously separating and cleaning blood cells in clinical practice.

Background technique ·

There are many methods for separating suspended particles in a liquid, and the more common method is centrifugation. However, in the case of separating small particles, especially where blood cells and plasma need to be separated, the use of a centrifugal separation device is not only very complicated, but also expensive, and it is easy to cause damage to blood cells at the same time.

Chinese Patent Application No. 911058486 discloses an apparatus for separating blood. The apparatus includes a transducer driving circuit, a transducer (ultrasonic generator), a reflective container and a blood container, wherein the transducer is capable of generating a column. The arc-shaped or tube-shaped transducer of the surface wave, the reflection container and the blood container have the same shape as the transducer, and the three are placed coaxially.

Chinese Patent Application No. 94104548.X also discloses an apparatus for separating blood. The apparatus includes a transducer driving circuit, a transducer (ultrasonic generator), and a reflective container and a blood container. The wall and the container may each have a cylindrical shape, a round shape or a rounded shape, and the three may be formed into different combinations, with the central axis perpendicular to the horizontal and overlapping each other.

One of the important applications of these instruments is to separate blood. However, none of the above-mentioned documents mentions the problem of blood cleaning during the ultrasonic separation of the instrument, nor does it mention the problems of uniformity and efficiency of blood cleaning during the ultrasonic separation.

An object of the present invention is to provide a device for ultrasonic separation and cleaning of a suspension.

It is still another object of the present invention to provide a device for separating suspended particles in a liquid with high cleaning uniformity and cleaning efficiency.

It is still another object of the present invention to provide an apparatus for separating suspended particles in a liquid having a high separation speed.

Another object of the present invention is to provide a blood separation system that can be applied clinically.

Other objects of the invention can be realized in the further elaboration of the invention.

Summary of invention

The invention relates to a device for ultrasonically separating suspended particles, especially micro particles such as blood cells in blood, and cleaning the suspended particles. The device includes a first container with a reflective wall, the first container being An ultrasonic generator in the container, an ultrasonic driver for driving the ultrasonic generator, and a second container for holding a fluid with suspended particles; the second container is located in the first container and is located on the reflective wall and Between the ultrasonic generator, between the second container and the first container, a matching liquid for ultrasonic transmission is contained, and an opening for injecting fluid is formed at the bottom of the second container; A plurality of partitions are partitioned into a plurality of compartments, and the compartments are in fluid communication at the top and bottom of the second container, respectively.

According to the present invention, the cleaning efficiency can be further improved by changing the number, shape, and position of the lift ports into which the fluid is injected.

The invention also relates to a blood separation system that can be used clinically.

Brief description of the drawings

Fig. 1 is a sectional view of one embodiment of the apparatus of the present invention.

2A-2B are schematic diagrams of two embodiments of the device of the present invention.

Figures 3A-3E are schematic views of a longitudinal section of a second container in some embodiments of the apparatus of the present invention. Fig. 4 is a schematic diagram of another embodiment of the apparatus of the present invention.

5A-5C are schematic diagrams of a separator of one embodiment of the apparatus of the present invention.

6A-6C are schematic diagrams of a slow-flow ring according to an embodiment of the device of the present invention.

Fig. 7 is a sectional view of one embodiment of the apparatus of the present invention.

Fig. 8 is a working schematic diagram of the blood separation system of the present invention.

Fig. 9 is an embodiment of the invention in which a cleaning solution is added.

Detailed description of the invention

After long-term research, the inventors discovered that when separating suspended particles from fluids, such as liquids, especially small particles, such as blood cells in blood, by ultrasonic methods, the separation container was divided into several relatively independent compartments, and these The compartments are communicated at the top and bottom of the second container, respectively, which can complete the separation and cleaning of suspended particles in the same container, and has high cleaning uniformity and cleaning efficiency, thereby improving the separation speed as a whole. And efficiency. This high cleaning uniformity and the improvement of the cleaning efficiency and the overall separation speed and efficiency are presumably because these compartments communicate with each other at the top and the bottom of the second container. When the cleaning liquid is added from the bottom of the container, the liquid ’s own Characteristics, to achieve the purpose of uniform addition of the cleaning liquid, so that it has a high cleaning uniformity; and because the cleaning liquid such as water in each compartment is basically flowing in a direction perpendicular to the liquid surface, so that it has a high Cleaning efficiency; and thereby improving the overall separation speed and efficiency.

Figure 1 shows the ultrasonic separation of a suspended particle, especially a small particle such as blood cells in blood, according to the present invention. And a cleaning device, including a first container 10 'with a reflecting wall, an ultrasonic generator 20 located in the first container, an ultrasonic driver (not shown) for driving the ultrasonic generator, and a container for holding suspended particles A fluid-tight second container 30; the second container is located in the first container, and is located between the reflective wall and the sonotrode; The matching liquid has at least one orifice 11 at the bottom of the second container for adding and draining suspension such as blood and washing liquid such as water; wherein the second container is partitioned into several thousands of compartments by a plurality of partitions 50 along its circumference, Each compartment is in fluid communication at the top 3 and the bottom 4.

Figure 2A is a schematic illustration of the scabbing of the device of the present invention. The second container 30 is partitioned into five compartments C1-C5, and these compartments communicate with each other at the top 3 and bottom 4 of the second container, respectively. In addition, the second container 30 is divided into two regions, that is, a waste liquid retention region 1 located at the upper part and an effective separation region 2 located at the lower part. The height of the effective separation region 2 corresponds to the effective action height of the ultrasonic wave generated by the ultrasonic generator. When a suspension such as blood or a cleaning solution such as water is added from the orifice 11, the air in the second container is exhausted from the opening 12. Due to the fluid communication effect, the level of the suspension such as blood or the cleaning solution such as water in each compartment is high. Will remain on the same level. That is, a cleaning liquid such as water is added from the orifice 11 and the cleaning liquid will pass through each compartment evenly before the cleaning liquid reaches the top 3 and communicates. The process of separation and cleaning with this separation device is as follows: First, a certain amount of suspension is added from the orifice 11, and the amount of suspension added should ensure that its interface is located in an effective separation area so that ultrasonic separation can be performed effectively. After the ultrasonic separation, suspended particles such as blood cells generally settle in the lower part of the second container; then a cleaning solution such as water is added, as long as the liquid level does not reach the top 3 of the second container and communicate with each other; finally, it is distinguished by effective detection methods such as optical detection methods Suspended particles such as blood cells and cleaning waste liquid, the suspended particles such as blood cells and waste liquid are sequentially extracted from the bottom hole 11 to achieve separation and cleaning of the suspended particles from the waste liquid.

Fig. 2B is a schematic diagram of another embodiment of the apparatus of the present invention. The second container 30 of the present invention is partitioned into five compartments C1-C5. These compartments communicate with each other at the top 3 and bottom 4 of the second container. An opening 12 is provided on the top 3 of the second container for exhausting the gas in the second container or inflating the second container. A cleaning waste liquid discharge port 5 is provided on the wall of each compartment above the effective separation area. After the ultrasonic separation, suspended particles such as blood cells settle in the lower part of the second container. At this time, a cleaning liquid such as water is added from the orifice 11; when the cleaning waste liquid will pass through the relatively independent compartment and enter the top 3, it will communicate. The orifice 11 is closed and pressure is applied from the opening 12. At this time, the waste liquid at the position above the cleaning waste liquid discharge port 5 is discharged through the cleaning waste liquid discharge port to the second container, so as to be separated from the suspended particles that have been separated and cleaned by ultrasound. Preferably, the cleaning waste liquid discharge port 5 is located above the effective separation area, more preferably, The cleaning waste liquid discharge port is set close to the effective separation area. The cleaning waste liquid discharge port 5 should ensure that the liquid above it will not flow out due to its own pressure. For example, a valve can be installed at each outlet. The cleaning waste liquid discharge ports are substantially at the same horizontal plane.

According to the present invention, the manner of adding a fluid such as a suspension and a cleaning solution through the orifice 11 can be various. The orifice 11 preferably allows at least part of the cleaning liquid to flow in the same direction along the circumferential direction of the second container, and can generate a certain vortex within each barrier, so that the suspension liquid such as blood and the cleaning liquid such as water are sufficient. Contact makes the blood wash more thoroughly and effectively. Such orifices can be made as shown in Figure 9, or added through one or more conduits that extend from the top to the bottom of the container. In this case, the end of the catheter is plus or minus 20 degrees from the horizontal direction, and more preferably 0 degrees from the horizontal.

The number of the orifices 11 may be greater than or equal to 1, which is related to the size of the second container and the like, preferably 2 to 6, and more preferably 3. In the case of multiple orifices, it is preferably evenly distributed along the circumferential direction of the second container, such as axially symmetrical. For example, when the number of the orifices 11 is three, they are distributed at a distance of 120 degrees from each other in the circumferential direction of the second container. The positions of the orifices with each other are preferably substantially on the same horizontal plane, so that the washing liquid can flow more uniformly, thereby improving the quality of blood washing.

If the density of the suspended particles is less than the density of the solvent, the suspended particles will accelerate to accumulate upward under the effect of ultrasound. In this case, appropriate changes in the above structure can still achieve the purpose of uniform and rapid separation of the washing liquid. Referring to FIG. 4, the containers 71 and 72 are each composed of a plurality of relatively independent compartment groups ^, and these compartments communicate at the top, where each of the compartments D1-D5 of the container 71 and each of the compartments E1-E5 of the container 72-correspondingly In connection, the overall position of the container 72 is higher than the horizontal position of the container 71. The working procedure is as follows: firstly add the suspension through the orifice 11 of the container 71, keep the air at the top 4 of the container 71 as small as possible, and perform ultrasonic separation; after the ultrasonic separation, fill the cleaning solution through the orifice 11 again. Since each compartment is relatively independent, the washing liquid enters each compartment uniformly under the action of gravity. When the cleaning is performed for a period or the waste liquid will pass through the container 72 and enter the communicating top 3 inches, the container 71 can be inflated through the orifice 11 to eject the waste liquid out of the opening 12 and then the gas through the orifice 11 Aspirate and continue adding lotion. The concentrated liquid of suspended particles is drawn out through the orifice 11 to complete a cleaning process.

In the above-mentioned structure, the opening of the container 72 connected to the container 71 may also be provided with a two-way valve, so that when the waste liquid will flow through the container 72 and enter the communicating top 3 inches, close the container 71 and the container 72-corresponding The channel of the container 72 is pressurized from the liter 12 of the container 72, and the waste liquid in each compartment of the container 72 is discharged from the container 72 through the other channel of the valve. Alternatively, the container 71 and the container 72 may be integrally formed.

According to the present invention, the partition may be a flat plate, and the partition may be perpendicular to the ultrasonic generator. The axis is placed substantially parallel or placed at an angle to the axis, preferably placed substantially parallel to the vertical axis of the ultrasonic generator; more preferably, the partition plate is arranged in the radial direction of the ultrasonic generator.

According to a preferred embodiment of the present invention, the upper part of the partition plate is parallel to the vertical axis of the ultrasonic generator, and the lower part is an inclined surface at a certain angle with the axis. Conversely, the upper part of the separator may be said to be inclined, and the lower part is parallel to the vertical axis of the ultrasonic generator. The inclined portion of the partition may be a flat surface or a curved surface, and preferably a smooth curved surface. The beveled portion will facilitate the rapid sedimentation of suspended particles during ultrasonic separation. The height ratio of the vertical portion of the partition to the inclined portion can be changed according to actual needs. Preferably, at least part of the horizontal cross-section of the partition points to the vertical axis of the ultrasonic generator, more preferably, the horizontal cross-section of each of the curved surfaces points to the axis, most preferably all of the partition The horizontal section line points to said axis. '

According to the present invention, the partition for partitioning the second container into a plurality of compartments may be evenly or non-uniformly distributed along the circumferential direction of the second container; it is preferably evenly distributed, so that when blood or a washing liquid such as water is added, Before the top of the container, the steric hindrance of the washing liquid flowing into and passing through the compartments becomes more consistent, so that the washing liquid such as water is added more uniformly, and the blood in each compartment is more uniformly washed. The number of partitions can be changed within a relatively large range according to the size of the second container. For separated blood, the number is usually 4 to 60, preferably 10 to 50, more preferably 20 to 40, and most preferably 30.

In the device of the present invention, the partitions may be the same type of partitions, or may be different types of partitions. Preferably, the partitions are the same type of partitions. When blood or a cleaning solution such as water is added to the container, before reaching the top of the second container, the steric hindrance of the cleaning solution flowing into and passing through the compartments becomes more consistent, so as to achieve a more uniform addition of the cleaning solution such as water, so that in each compartment The blood is more evenly washed.

According to the present invention, the partition should be sized to match the second container so that the compartments are relatively spaced apart, and the compartments are communicated at the top and bottom of the second container, respectively. The partition and the wall of the second container can be connected by any method known in the art, such as using the strain pressure of the inner and outer walls of the second container to fix or use an adhesive or directly with the second container. The inner or outer wall or both are integrated into one.

According to the present invention, the shapes of the first container and the ultrasonic generator may be various. For example, the wall surface of the first container and / or the sonotrode may be designed to be vertical or inclined, such as cylindrical, circular truncated or round truncated. The shapes of the first container and the ultrasonic generator of the present invention and their mutual positional relationship with the second container may be as disclosed in Chinese Patent Application Nos. 911058486 and 94104548. In order to effectively separate the ultrasonic generator, it is preferable to make the cylindrical ultrasonic It essentially acts on the effective separation area. Preferably, the first container and the second container are arranged coaxially with the vertical axis of the ultrasonic generator.

According to the present invention, the shape of the second container may be various, such as those disclosed in Chinese Patent Application Nos. 911058486 and 94104548. The wall surface can be designed to be vertical or inclined, such as cylindrical, circular truncated or round truncated truncated or its inner wall is wedge-shaped, or part of the cavity wall is cylindrical, and part of the cavity wall is round truncated. The angle of the wall of the second container with the vertical direction can achieve the purpose of facilitating rapid settlement. The second container is preferably a circular ring-shaped cavity; more preferably, the cross-sectional area of the waste liquid retention zone of the circular ring-shaped cavity is larger than the cross-sectional area of the effective separation zone, so that for a certain amount of suspension There is a large space to accommodate the cleaning seat liquid, and the external size of the ultrasonic separation device can be greatly reduced, saving space, as shown in Figs. 3A-E. FIG. 3A is a preferred configuration of the second container of the present invention. The outer wall of the hollow annular cavity is a single-diameter ring; the longitudinal section of the inner wall of the annular cavity is stepped. The upper and lower parts are also circular rings of a single diameter. The lower end of the upper part of the inner wall is higher than the upper end of the lower part of the inner wall, so that a truncated cone is formed between the upper and lower parts of the inner wall. The stepped portion has a generatrix at an angle to the level; the top end of the outer wall of the circular cavity is lower than the top of the inner wall. Therefore, the upper lid of the second container is also a truncated cone, and the The lower cover is a circular plate. FIG. 3B shows another preferred form of the second annular container, wherein the outer wall is stepped, the inner wall is circular, and the upper and lower covers are circular plates.

The volume of the second container, the size of the inner and outer diameters, and the volume of the lower portion for containing the suspension such as blood and the volume of the upper portion for the washing waste liquid may be changed according to actual needs, as long as the lower portion is large enough to hold The amount of suspension and the amount of waste produced when the upper part is large enough to hold the suspension such as blood to a certain extent. For the case of separating blood, the amount of blood added is generally 100-2000ml, preferably 300-1500ml, more preferably 500-1000ml; its inner diameter is generally 3-20cm, preferably 5-18cm, and more preferably 8-17cm. For industrial applications such as wastewater treatment, the amount of suspension per treatment can vary according to actual needs.

In addition, the second container may also adopt an inverted structure with an upper cross-sectional area smaller than a lower cross-sectional area. This structure is particularly suitable for a case where the density of suspended particles is less than the density of the solvent. According to the present invention, the ultrasonic separation and cleaning of the suspension may be performed by ultrasonic separation and then cleaning, or by ultrasonic separation and cleaning at the same time, or by ultrasonic separation and then cleaning by ultrasonic. Preferably, ultrasonic separation is performed first and then cleaning is performed, or ultrasonic separation is performed first and then cleaning is performed under ultrasonic action. The reflecting wall of the present invention can be used as a wall or a part of a wall of the first container. In order to increase the reflection effect of the reflecting wall on ultrasonic waves, a material with a large difference in acoustic resistance from the fluid or matching liquid to be treated should be selected as the reflecting wall. Conventional reflective wall materials are, for example, stainless steel, ¾, iron, aluminum, etc. Polyethylene or polyvinyl chloride materials can also be used, especially when the reflective wall also serves as the wall of the second container.

The thickness of the wall of the second container should be selected to facilitate ultrasonic transmission. Generally, the thinner the better, or take the half-wavelength of the ultrasonic wave used as the thickness. The material of the second container should be selected to be as consistent as possible with the acoustic resistance of the object to be treated, such as polyethylene or polypropylene.

According to the present invention, the mutual position and / or structure of the reflective wall and the ultrasonic generator is designed so that an angle β is formed between the ultrasonic incident wave generated by the ultrasonic generator and the ultrasonic reflected wave reflected from the reflective wall. The included angle β ranges from 5 to 90 °, preferably from 10 to 80 °.

The ultrasonic generator can have various vibration modes, such as radial vibration and thickness vibration. Generally, the size of the suspended particles is relatively large, and the radial vibration mode with a low ultrasonic frequency is adopted. When the particle size is relatively small, the thickness vibration mode is used. For example, when processing blood, a thickness vibration mode is preferably used. A protective layer or matching layer can be added to the ultrasonic generator to prevent corrosion, and a reflective layer such as polytetrafluoroethylene can be added to the reflective wall to protect the reflective wall.

According to the present invention, a suspension or a decanter such as water may be added uniformly from the bottom of the container; it may also be added from the upper portion of the container through a conduit communicating with the bottom of the container.

Different materials of the separator of the present invention can be selected according to actual needs. In the case of separating blood, it should be any material compatible with blood, such as polyethylene or polypropylene.

According to the present invention, a buffer device for buffering the liquid flow entering each compartment may be provided at the lower end of part or all of the compartments. The buffer device may also be integrated (a preferred embodiment of the present invention).

FIG. 7 shows an ultrasonic separation device for separating bleeding cells from blood, which is a preferred embodiment of the present invention. It includes a circular truncated ultrasonic generator 20, similar to the crusted hollow second container 30 shown in FIG. 3A, and a cylindrical first container 10 with a reflective wall, wherein the second container 30 is separated by a partition 50 (below its structure It is mentioned that there are thousands of compartments partitioned in the circumferential direction, and these compartments communicate with each other at the top 3 and the bottom 4 of the second container 30. The second container 30 is divided into a waste liquid retention area with a large cross-sectional area at the upper portion and an effective separation area with a small cross-sectional area at the lower portion. A cleaning waste is formed on the inner wall of each compartment above the effective separation area. The liquid discharge port 5 and the discharge port 5 are preferably set close to the effective separation area. The liquid discharge port of each discharge port 5 is connected to a waste liquid container (not shown in the figure) by means of a fluid channel. An opening 12 is formed on the top of the second container 30 for removing air from the second container and adding gas to the second container The cleaning waste liquid located above the cleaning waste liquid discharge port 5 is discharged from the second container. A slow flow ring 70 is also provided at the bottom of the second container, and its structure is shown in FIG. 6. The slow-flow ring 70 is a circular ring-shaped knot, and its cross-section is in the shape of a channel steel. The open end of the slow-flow ring 70 abuts on the circular lower cover of the second container, thereby forming a sealed annular chamber with the circular lower cover. 100. The top end surface of the slow-flow ring 70 abuts the lower end of each partition plate 50. At the position corresponding to each compartment at the top end surface of the slow-flow ring, an orifice 75 smaller than the cross-section of each compartment is formed, so that each partition The chambers are in fluid communication with each other through the orifices 75. There is a baffle plate at a certain height above the orifices 75, which are fixed above the orifices with posts to buffer the liquid flow entering the compartments. In addition, an orifice 76 is formed on the top end surface of the slow-flow ring, which is used to fit an infusion tube for injecting blood or cleaning liquid into the sealed annular chamber 100.

The separator used is shown in FIG. 5 and is composed of upper and lower parts 7, 9 and a middle part 8. The upper part 7 is a flat plate whose shape corresponds to the cross section of the waste liquid retention zone of the second container 30, but the top portion is cut away so that the compartments in the second container communicate with each other on the top of the second container. The lower part 8 is also a flat plate, and the middle part 9 is a smooth curved panel. The curved panel 8 is formed by rotating a line segment around the axis and moving along the axis at the same time, so that the horizontal section lines of the curved panel 8 point to the ultrasonic generator axis. Preferably, the horizontal section lines of the flat plates 7 and 9 also point to the axis of the ultrasonic generator, so as to block as little as possible the ultrasonic waves emitted by the ultrasonic generator and the ultrasonic waves reflected back from the reflecting wall of the first container, thereby improving the ultrasonic separation effect. The angle between the projection lines of the two flat plate portions 7, 9 in the top view (Fig. 5B) is generally 0-70 °, preferably 10-60 °, more preferably 20-50 °, and most preferably 30-40 °.

The material of the second container 30 is selected to be as consistent as possible with the sound resistance of blood, such as polyethylene, polypropylene, or polyvinyl chloride. The second container 30 and the ultrasonic generator 20 are used to contain a matching liquid such as water or sodium chloride. The second container 30 and the first container are also used for containing the matching liquid. The ultrasound generator 20, the second container 30 and the first container 10 are coaxially arranged.

The radial distance between the sonotrode 20 and the reflective wall of the first container can be selected according to the type and requirements of the substance to be processed. The preferred radial distance is an integer multiple of the half-wavelength of the ultrasonic wave used, so that a resonant cavity can be formed.

The ultrasonic power density emitted by the sonotrode is ascending, descending, and descending, so that the blood cells at the bottom can be denser and more completely separated, while the blood cells at the upper part are not exposed to excessive radiation during the entire separation process.

Fig. 8 is a flow chart for separating and cleaning the blood system of the present invention. The entire process includes the following steps:

(1) Blood is injected, the control valve F4 is closed, the peristaltic pump 100 is rotated, and the blood container 102 (this The second container of the inventive device) is discharged into the waste liquid bag D5, so that the blood mixed with the anticoagulant D1 is sucked into the blood container 102 through the blood filter L1 until the liquid level reaches the upper limit of the effective separation area;

(2) separation, starting the ultrasonic transducer at the central position of the blood container 102 to separate the blood in the container 102, the upper part of which is plasma, and the lower part of which is concentrated red blood cells;

(3) Cleaning. According to the method in step 1, suck the cleaning solution in the cleaning solution D2 into the blood container 102, so that it can fully clean the concentrated red blood cells during the ascent process. After the cleaning solution is filled in the container, perform ultrasonic separation);

(4) The liquid is discharged, the control valves Fl, F2 and F3 are closed, F4 is opened, and the peristaltic pump is reversed, and the gas is pumped from the waste liquid bag D5 into the blood container 102, so that the upper part of the container 102 is composed of cleaning liquid, plasma and the like The waste liquid is discharged into the waste liquid bag D5 through the pipeline 105;

(5) Blood is collected, the control valve F3 is opened, F4 is closed, the peristaltic pump 100 continues to reverse, and the washed red blood cells are input into the blood bag D3 for use.

According to the actual needs, during each processing (steps 1 to 5), steps 3 and 4 can be circulated multiple times; the blood volume is increased, and the number of treatments can be increased accordingly until all the blood to be processed is processed.

The ultrasonic blood separation system according to the present invention can be used not only for general blood separation, but also because of good separation effect, high separation speed, and good uniformity of liquid infusion. It can also perform blood separation operation in the clinic to meet some special needs in the clinic. .

The device of the present invention solves the process of ultrasonically separating blood from blood and the uniformity of the cleaning liquid such as water when added, thereby ensuring the uniformity of blood cleaning; and because the cleaning liquid such as water is basically along the The vertical direction of the liquid surface flows from the bottom to the top, which ensures the sufficient cleaning of the blood and improves the efficiency of the cleaning, thereby improving the separation speed as a whole; and the cleaning liquid such as water evenly enters all corners of the separation container during the cleaning process Fully mixed with blood, which greatly improves the washing effect.

Those skilled in the art will be able to design other solutions or give different solutions according to the ideas of the present invention, and these structures or solutions are considered to belong to the scope of the present invention and are included in the following claims.

Claims

-10-Claim

1. A device for separating suspended particles by a scale using ultrasound, comprising a first container with a skin shooting wall, an ultrasonic generator located in the first container, an ultrasonic driver for driving the ultrasonic generator, and a suspension belt A second container of granular fluid, the second container being located in the first container and between the reflecting wall and the ultrasonic generator, and a matching between the second container and the first container for facilitating ultrasonic transmission Liquid, at least one orifice is formed at the bottom of the second container, wherein the second container is partitioned into a plurality of compartments by a plurality of partitions along its circumferential direction, and these compartments are in fluid communication at the top and bottom of the second container, respectively.

2. The device according to claim 1, characterized in that an opening is provided on the top of said second container.

3. The device according to claim 1, characterized in that the orifice allows the added cleaning liquid to flow at least partially in the same direction along the circumferential direction of the second container. '

4. The device according to claim 3, wherein the number of said orifices is 2-6, preferably three, and said orifices are evenly distributed along the periphery of the second container.

5. The device according to claim 2, characterized in that a cleaning waste liquid discharge port is formed on the wall of each compartment for discharging the cleaning waste liquid above it to the second container, as described in the cleaning The waste liquid discharge port is located substantially on the same horizontal plane, and the top opening is used to fill the second container with air pressure.

6. The device according to any one of claims 1 to 5 is characterized in that a cavity is formed between the bottom of the second container and the lower end of each compartment, and the compartments are in fluid communication with each other via the cavity. The fluid enters the compartments evenly after filling the cavity; a cavity is formed between the top of the second container and the upper end of each compartment, and the compartments are in fluid communication with each other via the cavity.

7. The device according to claim 6, characterized in that the first container, the second container and the ultrasonic generator are arranged coaxially with respect to a vertical axis of the ultrasonic generator.

8. The device according to claim 7, characterized in that the partitions are evenly distributed along the circumferential direction of the second container.

9. The device according to claim 8, which is characterized in that the cross-sections of the partitions in the vertical direction along the horizontal direction point to the vertical axis of the ultrasonic generator.

10. The device according to claim 9, characterized in that the upper and lower portions of the partition are flat The middle part of the partition is a smooth curved panel.

11. The device according to any one of claims 3 to 9, wherein the second container is a hollow garden annular cavity, and the hollow circular annular cavity is located above the cleaning waste liquid discharge port. The cross-sectional area of the portion is larger than the cross-sectional area of the portion thereof below the cleaning waste liquid discharge port.

12. The device according to claim 11, characterized in that the outer wall of said second container is a single-diameter cylinder, and the longitudinal section of the inner wall of said second container along the vertical axis of the ultrasonic generator is stepped, The upper part and the lower part of the inner wall are each a single-diameter cylinder, and the lower end of the upper part of the inner wall is not lower than the upper end of the lower part of the inner wall, and a frustum-shaped stepped part connecting the upper part and the lower part of the inner wall.

13. The device according to claim 12, characterized in that the cross-sectional area of the lower end entrance of some compartments is smaller than the cross-sectional area of the compartment here, and a baffle is provided above the entrance for buffering into each compartment Flow.

14. The device according to claim 13 is characterized in that the cross-sectional area of the lower end entrances of all the compartments is smaller than the cross-sectional area of the compartments here, and a baffle is provided above the entrances to buffer the entry into each compartment Flow.

15. An apparatus for separating suspended particles by using ultrasound, comprising a first container with a reflective wall, an ultrasonic generator located in the first container, an ultrasonic driver for driving the super generator, and a suspension belt A second container of granular fluid, the second container being located in the first container and between the reflecting wall and the ultrasonic generator, and a matching between the second container and the first container for facilitating ultrasonic transmission Liquid, wherein the second container is divided into a plurality of compartments by a plurality of partitions along its circumferential direction, and these compartments are in fluid communication on the top of the second container, and an opening is on the top of the second container; and a third container is above the second container, The third container is longitudinally partitioned into a plurality of compartments. These compartments are in fluid communication with each of the second container compartments and are in fluid communication with the top of the third container. An opening is provided on the top of the third container.

16. A blood separation system comprising a device requiring 1-15.