WO1998031700A1 - Selection of proteins using rna-protein fusions - Google Patents
Selection of proteins using rna-protein fusions Download PDFInfo
- Publication number
- WO1998031700A1 WO1998031700A1 PCT/US1998/000807 US9800807W WO9831700A1 WO 1998031700 A1 WO1998031700 A1 WO 1998031700A1 US 9800807 W US9800807 W US 9800807W WO 9831700 A1 WO9831700 A1 WO 9831700A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- rna
- candidate
- fusion
- sequence
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98904574A EP0971946B1 (en) | 1997-01-21 | 1998-01-14 | Selection of proteins using rna-protein fusions |
DE69835143T DE69835143T2 (en) | 1997-01-21 | 1998-01-14 | SELECTION OF PROTEINS BY THE RNA PROTEIN FUSIONS |
KR1019997006594A KR100566859B1 (en) | 1997-01-21 | 1998-01-14 | Selection of proteins using rna-protein fusions |
AU62419/98A AU738328B2 (en) | 1997-01-21 | 1998-01-14 | Selection of proteins using RNA-protein fusions |
IL13101698A IL131016A (en) | 1997-01-21 | 1998-01-14 | Selection of proteins using rna-protein fusions |
CA2278786A CA2278786C (en) | 1997-01-21 | 1998-01-14 | Selection of proteins using rna-protein fusions |
JP53453498A JP3692542B2 (en) | 1997-01-21 | 1998-01-14 | Protein selection using RNA-protein fusions |
HK00106756A HK1027577A1 (en) | 1997-01-21 | 2000-10-24 | Selection of proteins using rna-protein fusions |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3596397P | 1997-01-21 | 1997-01-21 | |
US60/035,963 | 1997-01-21 | ||
US6449197P | 1997-11-06 | 1997-11-06 | |
US60/064,491 | 1997-11-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998031700A1 true WO1998031700A1 (en) | 1998-07-23 |
Family
ID=26712662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/000807 WO1998031700A1 (en) | 1997-01-21 | 1998-01-14 | Selection of proteins using rna-protein fusions |
Country Status (17)
Country | Link |
---|---|
US (5) | US6258558B1 (en) |
EP (2) | EP0971946B1 (en) |
JP (1) | JP3692542B2 (en) |
KR (1) | KR100566859B1 (en) |
CN (1) | CN1238366C (en) |
AT (2) | ATE332368T1 (en) |
AU (1) | AU738328B2 (en) |
CA (1) | CA2278786C (en) |
DE (1) | DE69835143T2 (en) |
DK (2) | DK0971946T3 (en) |
ES (2) | ES2373110T3 (en) |
HK (1) | HK1027577A1 (en) |
IL (1) | IL131016A (en) |
PT (2) | PT971946E (en) |
RU (1) | RU2233878C2 (en) |
TW (1) | TW589323B (en) |
WO (1) | WO1998031700A1 (en) |
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EP1105360A1 (en) * | 1998-08-17 | 2001-06-13 | Phylos, Inc. | Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules |
WO2001042494A2 (en) * | 1999-12-10 | 2001-06-14 | Phylos, Inc. | Test system for detecting analytes, a method for the production thereof and its use |
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WO2001083507A1 (en) * | 2000-05-05 | 2001-11-08 | Selegen | Identification of polypeptides and nucleic acid molecules using linkage between dna and polypeptide |
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