WO1997038729A8 - In vivo gene transfer methods for wound healing - Google Patents

In vivo gene transfer methods for wound healing

Info

Publication number
WO1997038729A8
WO1997038729A8 PCT/US1997/007301 US9707301W WO9738729A8 WO 1997038729 A8 WO1997038729 A8 WO 1997038729A8 US 9707301 W US9707301 W US 9707301W WO 9738729 A8 WO9738729 A8 WO 9738729A8
Authority
WO
WIPO (PCT)
Prior art keywords
dna
interest
wound healing
gene transfer
vivo gene
Prior art date
Application number
PCT/US1997/007301
Other languages
French (fr)
Other versions
WO1997038729A1 (en
Inventor
Steven A Goldstein
Jeffrey Bonadio
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Priority to PL97343864A priority Critical patent/PL189174B1/en
Priority to AU28212/97A priority patent/AU710386B2/en
Priority to AT97922578T priority patent/ATE298253T1/en
Priority to EP97922578A priority patent/EP0892644B1/en
Priority to JP53746397A priority patent/JP4114952B2/en
Priority to CA2251655A priority patent/CA2251655C/en
Priority to DE69733605T priority patent/DE69733605T2/en
Publication of WO1997038729A1 publication Critical patent/WO1997038729A1/en
Priority to NO19984729A priority patent/NO323843B1/en
Publication of WO1997038729A8 publication Critical patent/WO1997038729A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6953—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a fibre, a textile, a slab or a sheet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Abstract

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.
PCT/US1997/007301 1996-04-12 1997-04-11 In vivo gene transfer methods for wound healing WO1997038729A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL97343864A PL189174B1 (en) 1996-04-12 1997-04-11 Methods of in vivo transferring a gene for wound healing purposes
AU28212/97A AU710386B2 (en) 1996-04-12 1997-04-11 In vivo gene transfer methods for wound healing
AT97922578T ATE298253T1 (en) 1996-04-12 1997-04-11 IN VIVO GENE TRANSFER METHODS FOR WOUND HEALING
EP97922578A EP0892644B1 (en) 1996-04-12 1997-04-11 In vivo gene transfer methods for wound healing
JP53746397A JP4114952B2 (en) 1996-04-12 1997-04-11 In vivo gene transfer method for wound healing
CA2251655A CA2251655C (en) 1996-04-12 1997-04-11 In vivo gene transfer methods for wound healing
DE69733605T DE69733605T2 (en) 1996-04-12 1997-04-11 IN VIVO GENTRANSFER METHODS FOR WOUND HEALING
NO19984729A NO323843B1 (en) 1996-04-12 1998-10-09 Use of a biocompatible matrix for the preparation of a drug for regulating angiogenesis such as the promotion or inhibition of blood vessel formation.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/631,334 1996-04-12
US08/631,334 US5962427A (en) 1994-02-18 1996-04-12 In vivo gene transfer methods for wound healing

Publications (2)

Publication Number Publication Date
WO1997038729A1 WO1997038729A1 (en) 1997-10-23
WO1997038729A8 true WO1997038729A8 (en) 1999-04-22

Family

ID=24530760

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/007301 WO1997038729A1 (en) 1996-04-12 1997-04-11 In vivo gene transfer methods for wound healing

Country Status (12)

Country Link
US (1) US5962427A (en)
EP (2) EP1510224A1 (en)
JP (1) JP4114952B2 (en)
CN (2) CN102274522A (en)
AT (1) ATE298253T1 (en)
AU (1) AU710386B2 (en)
CA (1) CA2251655C (en)
DE (1) DE69733605T2 (en)
NO (1) NO323843B1 (en)
PL (1) PL189174B1 (en)
RU (1) RU2170104C2 (en)
WO (1) WO1997038729A1 (en)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653291B1 (en) * 1992-11-13 2003-11-25 Purdue Research Foundation Composition and method for production of transformed cells
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US6528483B2 (en) 1995-06-07 2003-03-04 André Beaulieu Method of producing concentrated non-buffered solutions of fibronectin
JPH11513405A (en) * 1995-10-11 1999-11-16 カイロン コーポレイション Formulations of PDGF, KGF, IGF, and IGFBP for wound healing
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6387700B1 (en) 1996-11-04 2002-05-14 The Reagents Of The University Of Michigan Cationic peptides, Cys-Trp-(LYS)n, for gene delivery
ATE296117T1 (en) * 1997-03-07 2005-06-15 Wistar Inst USE OF ADENOVIRAL VECTORS EXPRESSING PDGF OR VEGF TO HEAL TISSUE DEFECTS AND TO INDUCE HYPERVASCULISM IN MAMMAL TISSUES
US8858981B2 (en) 1997-10-10 2014-10-14 Ed. Geistlich Soehne Fuer Chemistrie Industrie Bone healing material comprising matrix carrying bone-forming cells
US20050186283A1 (en) 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
JP2001525173A (en) * 1997-12-04 2001-12-11 ジェンザイム・コーポレーション Compositions and methods for inducing gene expression
NL1007908C2 (en) * 1997-12-24 1999-06-25 Fuji Photo Film Bv Silver halide emulsions with recombinant collagen suitable for photographic administration and their preparation.
US6475994B2 (en) * 1998-01-07 2002-11-05 Donald A. Tomalia Method and articles for transfection of genetic material
US6395253B2 (en) 1998-04-23 2002-05-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production
US20030039694A1 (en) * 1998-04-28 2003-02-27 Martin John Francis Periadventitial delivery device
WO1999058656A2 (en) * 1998-05-13 1999-11-18 The Regents Of The University Of Michigan Sustained dna delivery from structural matrices
US6458109B1 (en) 1998-08-07 2002-10-01 Hill-Rom Services, Inc. Wound treatment apparatus
ATE241397T1 (en) 1999-03-19 2003-06-15 Univ Michigan MINERALIZATION AND CELLULAR STRUCTURING OF BIOMATERIAL SURFACES
US6767928B1 (en) * 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6258124B1 (en) * 1999-05-10 2001-07-10 C. R. Bard, Inc. Prosthetic repair fabric
WO2000072761A1 (en) * 1999-05-29 2000-12-07 Tyco Health Care Group, Lp Bioabsorbable blends and surgical articles therefrom
AU5624400A (en) * 1999-06-18 2001-01-09 Collaborative Group, Ltd., The Hyaluronic acid film and matrix for sustained gene transfer
RU2245722C2 (en) * 1999-06-22 2005-02-10 Рисерч Дивелопмент Фаундейшн Advanced wound cover for improving wound healing
US6770740B1 (en) 1999-07-13 2004-08-03 The Regents Of The University Of Michigan Crosslinked DNA condensate compositions and gene delivery methods
MXPA02000877A (en) * 1999-07-28 2002-08-06 Regeneration Tech Inc Cartilage or bone matrix as a nucleic acid delivery vehicle.
AU7585300A (en) * 1999-09-14 2001-04-17 University Of Virginia Patent Foundation Composition and method for treating wounds
EP1114862A3 (en) * 1999-11-17 2003-08-06 Switch Biotech Aktiengesellschaft Use of polyeptides or their encoding nucleic acids for the diagnosis or treatment of skin diseases and their use in indentifying pharmacologically acitve substances
US6764462B2 (en) 2000-11-29 2004-07-20 Hill-Rom Services Inc. Wound treatment apparatus
US6824533B2 (en) 2000-11-29 2004-11-30 Hill-Rom Services, Inc. Wound treatment apparatus
US20010044413A1 (en) * 1999-12-01 2001-11-22 Glenn Pierce In situ bioreactors and methods of use thereof
AU4724401A (en) 2000-02-28 2001-09-12 Genesegues Inc Nanocapsule encapsulation system and method
US6527801B1 (en) * 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
DE10020125A1 (en) * 2000-04-18 2001-10-25 Friedrich Schiller Uni Jena Bu Agent for stimulating bone regrowth, useful as insert after surgery for bone cancer, comprises single sequence expressing a fusion of growth factor and protease inhibitor
US6319715B1 (en) 2000-04-21 2001-11-20 Cornell Research Foundation, Inc. Method of enhancing the delivery of nucleic acids using silica nanoparticles
WO2001082973A2 (en) * 2000-04-28 2001-11-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
EP1294325B1 (en) 2000-05-22 2008-09-10 Arthur C. Coffey Combination sis and vacuum bandage
DE10025609A1 (en) * 2000-05-24 2001-12-13 Univ Ludwigs Albert Transfection system
EP1176200A3 (en) * 2000-06-20 2005-01-12 Switch Biotech Aktiengesellschaft Use of polyeptides or their encoding nucleic acids for the diagnosis or treatment of skin diseases or wound healing and their use in indentifying pharmacologically acitve substances
US6939540B1 (en) 2000-07-31 2005-09-06 Cornell Research Foundation, Inc. Method of enhancing bone density
JP2004520009A (en) 2000-08-08 2004-07-08 エム．ジー．ヴィ．エス． リミテッド Nucleic acid constructs, vascular cells transformed thereby, pharmaceutical compositions and methods using same for inducing angiogenesis
WO2002013610A1 (en) * 2000-08-17 2002-02-21 Mirus Corporation Nucleic acid expression from linear nucleic acids
AUPR030900A0 (en) 2000-09-22 2000-10-12 Queensland University Of Technology Growth factor complex
AU2001296585A1 (en) * 2000-10-06 2002-04-15 Michael F. Holick Regulation of cell proliferation and differentiation using topically applied nucleic acid molecules
US6855135B2 (en) 2000-11-29 2005-02-15 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US6685681B2 (en) 2000-11-29 2004-02-03 Hill-Rom Services, Inc. Vacuum therapy and cleansing dressing for wounds
US6752831B2 (en) 2000-12-08 2004-06-22 Osteotech, Inc. Biocompatible osteogenic band for repair of spinal disorders
EP1341484B1 (en) * 2000-12-08 2009-05-06 Osteotech, Inc. Implant for orthopedic applications
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7098374B2 (en) * 2001-02-09 2006-08-29 University Of Florida Research Foundation, Inc. Human disease modeling using somatic gene transfer
EP1389071A2 (en) * 2001-02-26 2004-02-18 Sabina Glozman Systems devices and methods for intrabody targeted delivery and reloading of therapeutic agents
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US20060094112A1 (en) * 2001-03-07 2006-05-04 Omotunde Babalola Biological scaffold
DE10121255A1 (en) * 2001-04-30 2002-11-07 Switch Biotech Ag Use of alpha 1-antichymotrypsin polypeptide or nucleic acids encoding the polypeptide, or of a cell expressing the polypeptide, or of antibody against the polypeptide, for diagnosing, treating or preventing poorly-healing wounds
WO2002089658A2 (en) * 2001-05-07 2002-11-14 New York University Microvascular free flaps for local or systemic delivery
ATE555798T1 (en) * 2001-08-09 2012-05-15 Giuseppe Intini TISSUE IMPLANTS AND METHODS FOR THE PRODUCTION AND USE THEREOF
US7217570B2 (en) * 2001-08-23 2007-05-15 The Wistar Institute Of Anatomy And Biology Organotypic intestinal culture and methods of use thereof
WO2003029429A2 (en) * 2001-10-03 2003-04-10 Selective Genetics, Inc. Traversal of nucleic acid molecules through a fluid space and expression in repair cells
US20030134811A1 (en) * 2001-10-09 2003-07-17 John Jackson Methods and compositions comprising hydroxyapatite useful for the administration of therapeutic agents
CA2462877A1 (en) 2001-10-11 2003-04-17 Hill-Rom Services, Inc. Waste container for negative pressure therapy
US20040031067A1 (en) * 2001-10-11 2004-02-12 Meenhard Herlyn Regulation of human skin healing
KR20030035047A (en) * 2001-10-29 2003-05-09 (주)바이오코돈 Use of BMP-4 gene and its gene product for treatment and diagnosis of Lichen Planus
AU2002358947A1 (en) * 2001-12-05 2003-06-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nanoparticles containing polymeric nucleic acid homologs, pharmaceutical compositions and articles of manufacture containing same and methods of use thereof
WO2003057070A2 (en) 2001-12-26 2003-07-17 Hill-Rom Services Inc. Vented vacuum bandage and method
AU2002359829A1 (en) 2001-12-26 2003-07-24 Hill-Rom Services, Inc. Vacuum bandage packing
AU2002359830A1 (en) 2001-12-26 2003-07-24 Hill-Rom Services, Inc. Wound vacuum therapy dressing kit
WO2003082346A1 (en) * 2002-04-02 2003-10-09 'asgl-Farmatsevticheskie Innovatsii', Zakrytoe Aktsionernoe Obschestvo Recombinant chimeric protein for the target delivery of dna to eukariotic target cells
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
EP3424472A1 (en) 2002-04-10 2019-01-09 KCI Medical Resources Access openings in vacuum bandage
WO2004000164A2 (en) * 2002-06-24 2003-12-31 Amniotech, Inc. Amniotic membrane mediated delivery of bioactive molecules
US20040009155A1 (en) * 2002-07-12 2004-01-15 Maria Palasis Method for sustaining direct cell delivery
CA2495385A1 (en) 2002-08-21 2004-03-04 Hill-Rom Services, Inc. Wound packing for preventing wound closure
US7682392B2 (en) * 2002-10-30 2010-03-23 Depuy Spine, Inc. Regenerative implants for stabilizing the spine and devices for attachment of said implants
WO2004041319A1 (en) * 2002-11-07 2004-05-21 Pentax Corporation Therapeutic device for osteogenesis
US20080026077A1 (en) * 2002-11-12 2008-01-31 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
US20050026859A1 (en) * 2002-11-12 2005-02-03 John Hilfinger Methods and compositions of gene delivery agents for systemic and local therapy
WO2004043495A1 (en) * 2002-11-12 2004-05-27 The Circle For The Promotion Of Science And Engineering Delivery agent, method of delivering a target substance to cells, method for producing delivery agent, composition for producing delivery agent, and kit for producing delivery agent
AU2003900481A0 (en) 2003-02-05 2003-02-20 Queensland University Of Technology Synthetic modulators of cell migration and growth
WO2011063477A1 (en) 2009-11-30 2011-06-03 Queensland University Of Technology Fibronectin: growth factor chimeras
US20100143442A1 (en) 2003-02-05 2010-06-10 Queensland University Of Technology Growth factor complexes and modulation of cell migration and growth
WO2004083450A2 (en) * 2003-03-21 2004-09-30 The General Hospital Corporation D/B/A Massachusetts General Hospital Hyperbranched dendron and methods of synthesis and use thereof
JP4426532B2 (en) * 2003-10-15 2010-03-03 独立行政法人産業技術総合研究所 Implants for bone and cartilage regeneration using transcription factors
EP1701672A4 (en) 2003-12-19 2011-04-27 Osteotech Inc Tissue-derived mesh for orthopedic regeneration
US20050244451A1 (en) * 2004-05-03 2005-11-03 Robert Diaz Method and device for reducing susceptibility to fractures in vertebral bodies
US20050244499A1 (en) * 2004-05-03 2005-11-03 Robert Diaz Method and device for reducing susceptibility to fractures in long bones
DK2497492T3 (en) 2004-06-01 2018-11-26 Icahn School Med Mount Sinai Genetically modified swine influenza virus and its applications
EP1778310A2 (en) * 2004-07-21 2007-05-02 Medtronic, Inc. Medical devices and methods for reducing localized fibrosis
CA2573671A1 (en) * 2004-07-21 2006-02-23 Medtronic, Inc. Methods for reducing or preventing localized fibrosis using sirna
AU2005298344B2 (en) 2004-10-25 2011-02-10 Varian Medical Systems, Inc. Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US20060089642A1 (en) * 2004-10-27 2006-04-27 Diaz Robert L Prefracture spinal implant for osteoporotic unfractured bone
US20060206139A1 (en) * 2005-01-19 2006-09-14 Tekulve Kurt J Vascular occlusion device
US20070087059A1 (en) * 2005-10-17 2007-04-19 Frank Everaerts Bioactive delivery matrix compositions and methods
ES2526705T3 (en) 2005-10-25 2015-01-14 The Johns Hopkins University Methods and compositions for the treatment of Marfan syndrome and associated disorders
EP1998810A4 (en) 2006-03-13 2009-09-02 Univ Johns Hopkins Augmentation of endothelial thromboresistance
IN2014CN04406A (en) 2006-03-30 2015-09-04 Ptc Therapeutics Inc
WO2008005533A2 (en) * 2006-07-06 2008-01-10 Aaron Thomas Tabor Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
CA2671437A1 (en) * 2006-10-31 2008-05-29 University Of Rochester Targeted delivery of therapeutic agents with lyophilized matrices
DE102006051623A1 (en) 2006-11-02 2008-07-31 Horn, Peter A. Gene transfer into target cells in vivo comprises applying a gene transfer vector and a transduction enhancer at the same time and place
SI2211851T1 (en) * 2007-10-09 2014-11-28 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada, Reno Laminin-1 for use in enhancing muscle regeneration after injury or for improving wound healing if administered systemically
EP4219708A3 (en) 2009-07-17 2023-10-11 Aaron Thomas Tabor Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
DK2569342T3 (en) 2010-05-11 2022-04-19 Howmedica Osteonics Corp Multivalent Organophosphorus Metal Compounds and Interpenetrating Polymer Adhesive Network Compositions and Methods
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
EP2660314A4 (en) 2010-12-27 2014-09-03 Lsip Llc iPS CELLS AND METHOD FOR GENERATING SAME
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
EP2799537B1 (en) 2011-12-28 2021-09-22 Kyoto Prefectural Public University Corporation Normalization of culture of corneal endothelial cells
RU2519326C2 (en) * 2011-12-29 2014-06-10 Общество с ограниченной ответственностью "НекстГен" Biocomposite for performing reparative processes following injuries in mammals, methods for preparing (versions) and using same
EP2849778B1 (en) 2012-03-13 2017-12-27 James Cook University Ac-TMP-2 FOR USE IN TREATING INFLAMMATION
US9566310B2 (en) 2012-09-10 2017-02-14 Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Reno Methods of treating muscular dystrophy
EP2968273A4 (en) 2013-03-15 2016-08-31 Univ Nevada Methods of treating muscular dystrophy
RU2712967C2 (en) 2013-10-31 2020-02-03 Киото Прифекчурал Паблик Юниверсити Корпорэйшн Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium
WO2016036960A1 (en) 2014-09-03 2016-03-10 Genesegues, Inc. Therapeutic nanoparticles and related compositions, methods and systems
RU2597786C2 (en) * 2015-02-10 2016-09-20 Общество с ограниченной ответственностью "НекстГен" Method for creating personalized gene-activated implant for bone tissue regeneration
WO2016187312A1 (en) 2015-05-18 2016-11-24 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and compositions for treating an alphavirus infection
JP2019501961A (en) * 2015-12-03 2019-01-24 ディーエヌエー エッセンス ゲーエムベーハーＤｎａ Ｅｓｓｅｎｃｅ Ｇｍｂｈ Oligonucleotides in food, beverage, cosmetic and pharmaceutical compositions
CA3030603A1 (en) 2016-07-14 2018-01-18 University Of Southern California Methods and composition for producing and using immune cells and stem cells for cell-based therapies
US20200179490A1 (en) * 2016-07-18 2020-06-11 University Of Delaware Collagen-mimetic peptide mediated delivery of nucleic acid carriers for efficient delivery from collagen
CN107913436A (en) * 2016-10-09 2018-04-17 刘英芹 Act on the bone and soft tissue synchronizing regeneration derivant of disability tissue in situ
IL303969A (en) 2021-01-24 2023-08-01 David Forrest Michael Bnjm

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243775A (en) * 1978-11-13 1981-01-06 American Cyanamid Company Synthetic polyester surgical articles
US4300565A (en) * 1977-05-23 1981-11-17 American Cyanamid Company Synthetic polyester surgical articles
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4166800A (en) * 1977-08-25 1979-09-04 Sandoz, Inc. Processes for preparation of microspheres
US4181983A (en) * 1977-08-29 1980-01-08 Kulkarni R K Assimilable hydrophilic prosthesis
DE2843963A1 (en) * 1978-10-09 1980-04-24 Merck Patent Gmbh BODY-RESORBABLE SHAPED MATERIAL BASED ON COLLAGEN AND THEIR USE IN MEDICINE
US4390519A (en) * 1978-05-19 1983-06-28 Sawyer Philip Nicholas Bandage with hemostatic agent and methods for preparing and employing the same
FR2439003A1 (en) * 1978-10-20 1980-05-16 Anvar NEW OSTEOSYNTHESIS PARTS, THEIR PREPARATION AND THEIR APPLICATION
JPS6032505B2 (en) * 1979-03-19 1985-07-29 株式会社吉野工業所 liquid sprayer
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4761471A (en) * 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US5366734A (en) 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4585797A (en) * 1981-04-13 1986-04-29 Seton Company Cosmetic and pharmaceutical sheet material containing polypeptides
US4591501A (en) * 1981-04-13 1986-05-27 Seton Company Cosmetic and pharmaceutical sheet material containing polypeptides
US4472840A (en) * 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4409332A (en) * 1982-01-12 1983-10-11 Jefferies Steven R Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same
US4670393A (en) * 1982-03-22 1987-06-02 Genentech, Inc. DNA vectors encoding a novel human growth hormone-variant protein
FR2524312B1 (en) * 1982-04-01 1985-10-04 Tech Cuir Centre NOVEL FORMS OF MICRO-ENCAPSULATION OF DRUG SUBSTANCES BY HOMOGENEOUS LAYERS OF NATIVE COLLAGEN
US4538603A (en) * 1982-04-22 1985-09-03 E. R. Squibb & Sons, Inc. Dressings, granules, and their use in treating wounds
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
US4539981A (en) * 1982-11-08 1985-09-10 Johnson & Johnson Products, Inc. Absorbable bone fixation device
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US5197977A (en) 1984-01-30 1993-03-30 Meadox Medicals, Inc. Drug delivery collagen-impregnated synthetic vascular graft
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4578384A (en) * 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
CA1295796C (en) * 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
US5001169A (en) * 1984-10-24 1991-03-19 Collagen Corporation Inductive collagen-based bone repair preparations
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5128326A (en) * 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US5223263A (en) 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
US5273964A (en) 1985-03-20 1993-12-28 Lemons J E Inorganic and organic composition for treatment of bone lesions
JPH0662679B2 (en) * 1985-06-21 1994-08-17 新田ゼラチン株式会社 Tissue-friendly collagen and its manufacturing method
US4889119A (en) * 1985-07-17 1989-12-26 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US4741337A (en) * 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US4806523A (en) * 1985-08-06 1989-02-21 Collagen Corporation Method of treating inflammation
JPH0624964B2 (en) * 1985-09-23 1994-04-06 東燃株式会社 Calcium phosphate-based hydroxyapatite and method for producing the same
US4776890A (en) * 1985-12-18 1988-10-11 Collagen Corporation Preparation of collagen hydroxyapatite matrix for bone repair
US5011692A (en) * 1985-12-28 1991-04-30 Sumitomo Pharmaceuticals Company, Limited Sustained pulsewise release pharmaceutical preparation
US5133755A (en) 1986-01-28 1992-07-28 Thm Biomedical, Inc. Method and apparatus for diodegradable, osteogenic, bone graft substitute device
EP0248531A3 (en) * 1986-05-02 1988-09-28 Southern Research Institute Encapsulated nucleic acids
US5108922A (en) * 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5187076A (en) 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5366875A (en) 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5037749A (en) * 1986-07-08 1991-08-06 Protein Foods Group Inc. Porous immobilization support prepared from animal bone
US4839130A (en) * 1986-07-17 1989-06-13 United States Surgical Corporation Process of making an absorbable surgical device
US4744365A (en) * 1986-07-17 1988-05-17 United States Surgical Corporation Two-phase compositions for absorbable surgical devices
JPS6368155A (en) * 1986-09-11 1988-03-28 グンゼ株式会社 Bone bonding pin
US5227157A (en) 1986-10-14 1993-07-13 Board Of Regents, The University Of Texas System Delivery of therapeutic agents
FI80605C (en) * 1986-11-03 1990-07-10 Biocon Oy Bone surgical biocomposite material
US4833125A (en) * 1986-12-05 1989-05-23 The General Hospital Corporation Method of increasing bone mass
US5051272A (en) * 1988-07-19 1991-09-24 United States Surgical Corporation Method for improving the storage stability of a polymeric article susceptible to hydrolytic degradation and resulting article
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US4844854A (en) * 1987-09-22 1989-07-04 United States Surgical Corporation Process for making a surgical device using two-phase compositions
FR2623402B1 (en) * 1987-11-19 1994-04-29 Solvay ARTICLE OF LACTIC ACID POLYMER FOR USE IN PARTICULAR AS A BIODEGRADABLE PROSTHESIS AND METHOD FOR THE PRODUCTION THEREOF
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US4961707A (en) * 1987-12-22 1990-10-09 University Of Florida Guided periodontal tissue regeneration
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
US5039660A (en) * 1988-03-02 1991-08-13 Endocon, Inc. Partially fused peptide pellet
US5137669A (en) * 1988-03-02 1992-08-11 Endocon, Inc. Manufacture of partially fused peptide pellet
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5344654A (en) 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5250302A (en) 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5324819A (en) 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US4865846A (en) * 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US4882150A (en) * 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US5124155A (en) * 1988-06-21 1992-06-23 Chiron Ophthalmics, Inc. Fibronectin wound-healing dressings
US5110604A (en) * 1988-06-30 1992-05-05 Collagen Corporation Processes for producing collagen matrixes and methods of using same
US4956178A (en) * 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US4902508A (en) * 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
DE3825211A1 (en) * 1988-07-25 1990-02-01 Henkel Kgaa IMPROVED BODY RESORBONABLE WAXES (III)
US5250584A (en) 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5470829A (en) 1988-11-17 1995-11-28 Prisell; Per Pharmaceutical preparation
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
JPH06104116B2 (en) * 1988-11-29 1994-12-21 三菱化成株式会社 Wound dressing
US5324520A (en) 1988-12-19 1994-06-28 Vipont Pharmaceutical, Inc. Intragingival delivery systems for treatment of periodontal disease
US4957902A (en) * 1988-12-20 1990-09-18 Board Of Regents, The University Of Texas System Peptide inhibitors of wound contraction
DE68915132T2 (en) 1988-12-22 1994-12-08 American Cyanamid Co Process for the treatment of periodontitis by protracted drug delivery of medicinal products in the tooth cavity, composition thereof and device for administration.
US4988358A (en) * 1988-12-28 1991-01-29 Eppley Barry L Method for promoting hard tissue growth and repair in mammals
US4884854A (en) * 1989-03-16 1989-12-05 Joffe Edward J Interconnecting panels for knockdown structures
US5698531A (en) 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US4946450A (en) * 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US5171670A (en) 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5077049A (en) * 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5723119A (en) 1989-07-28 1998-03-03 Schering Corporation Method for enhancing wound healing/repair with IL-4
US5196185A (en) 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5268178A (en) 1989-09-25 1993-12-07 The Board Of Regents, The University Of Texas System Biodegradable antibiotic implants and methods of their use in treating and preventing infections
US5286634A (en) 1989-09-28 1994-02-15 Stadler Joan K Synergistic method for host cell transformation
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
CN1052695A (en) 1989-12-22 1991-07-03 中国科学院生物物理研究所 A kind of method of metastatic gene and the particle gun of metastatic gene thereof
US5185152A (en) 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
US5350580A (en) 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5103840A (en) * 1990-05-07 1992-04-14 Kavoussi Harold P Viscoelastic collagen gel for ophthalmic surgery
US5059123A (en) * 1990-05-14 1991-10-22 Jernberg Gary R Periodontal barrier and method for aiding periodontal tissue regeneration
US5288496A (en) 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
DK0528978T3 (en) 1990-05-16 2003-02-17 Southern Res Inst Microcapsules for regulated delivery and their use in stimulating nerve fiber growth
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5080665A (en) * 1990-07-06 1992-01-14 American Cyanamid Company Deformable, absorbable surgical device
US5120322A (en) * 1990-06-13 1992-06-09 Lathrotec, Inc. Method and apparatus for treatment of fibrotic lesions
US5460831A (en) 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
US5324307A (en) 1990-07-06 1994-06-28 American Cyanamid Company Polymeric surgical staple
US5081106A (en) * 1990-07-16 1992-01-14 The Oregon Health Sciences University Wound dressing protocol utilizing collagen gelatin formed with iodine
US5128136A (en) * 1990-07-16 1992-07-07 The Oregon Health Sciences University Wound healing kit comprised of gelable collagen
US5263985A (en) 1990-08-14 1993-11-23 Pfizer Hospital Products Group, Inc. Bone growth stimulator
DE69133338T2 (en) * 1990-09-26 2004-04-15 Genetics Institute, LLC, Cambridge BMP-5 DERIVATIVES
ATE150648T1 (en) * 1990-11-26 1997-04-15 Robert R Recker TREATMENT OF OSTEOPOROSIS USING GROWTH HORMONE RELEASING FACTOR (GRF) IN CONJUNCTION WITH PARATHYROID HORMONE (PTH)
US5206028A (en) 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US5320624A (en) 1991-02-12 1994-06-14 United States Surgical Corporation Blends of glycolide and/or lactide polymers and caprolactone and/or trimethylene carbonate polymers and absorbable surgical devices made therefrom
US5208219A (en) 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
US5171217A (en) * 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
CA2082411A1 (en) 1991-06-28 1992-12-29 Robert D. Rosenberg Localized oligonucleotide therapy
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5317010A (en) 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
US5298422A (en) 1991-11-06 1994-03-29 Baylor College Of Medicine Myogenic vector systems
US5306303A (en) 1991-11-19 1994-04-26 The Medical College Of Wisconsin, Inc. Bone induction method
US5326357A (en) 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
US5792751A (en) 1992-04-13 1998-08-11 Baylor College Of Medicine Tranformation of cells associated with fluid spaces
FI91713C (en) * 1992-04-23 1994-08-10 Axidental Oy New bioactive coatings and their manufacture and use
US5326350A (en) 1992-05-11 1994-07-05 Li Shu Tung Soft tissue closure systems
WO1994001139A1 (en) * 1992-07-13 1994-01-20 Baylor College Of Medicine Targeting somatic gene therapy to joints
US5281419A (en) 1992-09-28 1994-01-25 Thomas Jefferson University Biodegradable drug delivery system for the prevention and treatment of osteomyelitis
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
AU6014094A (en) 1992-12-02 1994-06-22 Baylor College Of Medicine Episomal vectors for gene therapy
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
JP2002515731A (en) * 1995-11-06 2002-05-28 マウント・サイナイ・ホスピタル・コーポレイション Reformed mineralized cartilage tissue

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