WO1997032591A1 - Method of promoting bone growth with hyaluronic acid and growth factors - Google Patents
Method of promoting bone growth with hyaluronic acid and growth factors Download PDFInfo
- Publication number
- WO1997032591A1 WO1997032591A1 PCT/US1997/004810 US9704810W WO9732591A1 WO 1997032591 A1 WO1997032591 A1 WO 1997032591A1 US 9704810 W US9704810 W US 9704810W WO 9732591 A1 WO9732591 A1 WO 9732591A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bone
- bfgf
- composition
- growth
- hyaluronic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53207097A JP2002504083A (en) | 1996-03-05 | 1997-03-05 | Method for promoting bone growth by hyaluronic acid and growth factors |
NZ331238A NZ331238A (en) | 1996-03-05 | 1997-03-05 | Method of promoting bone growth with hyaluronic acid and growth factors (bFGF) |
CA2246747A CA2246747C (en) | 1996-03-05 | 1997-03-05 | Method of promoting bone growth with hyaluronic acid and growth factors |
EP97916976A EP0910389A4 (en) | 1996-03-05 | 1997-03-05 | Method of promoting bone growth with hyaluronic acid and growth factors |
AU25449/97A AU729086C (en) | 1996-03-05 | 1997-03-05 | Method of promoting bone growth with hyaluronic acid and growth factors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61169096A | 1996-03-05 | 1996-03-05 | |
US08/611,690 | 1996-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997032591A1 true WO1997032591A1 (en) | 1997-09-12 |
Family
ID=24450043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/004810 WO1997032591A1 (en) | 1996-03-05 | 1997-03-05 | Method of promoting bone growth with hyaluronic acid and growth factors |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0910389A4 (en) |
JP (1) | JP2002504083A (en) |
CN (1) | CN1149088C (en) |
WO (1) | WO1997032591A1 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6372257B1 (en) | 1999-06-29 | 2002-04-16 | J. Alexander Marchosky | Compositions and methods for forming and strengthening bone |
EP1198235A1 (en) * | 1999-07-26 | 2002-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
US6699471B2 (en) | 1998-12-21 | 2004-03-02 | Fidia Advanced Biopolymers, Srl | Injectable hyaluronic acid derivative with pharmaceuticals/cells |
US6831178B2 (en) | 2000-04-19 | 2004-12-14 | Shionogi & Co., Ltd. | Process for preparation of sulfonamide derivatives and crystals thereof |
EP1731193A1 (en) * | 2001-07-16 | 2006-12-13 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
WO2007092829A2 (en) * | 2006-02-07 | 2007-08-16 | Shire Human Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moiety |
EP0957943B2 (en) † | 1997-02-07 | 2008-11-26 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
US7608580B2 (en) | 1999-10-15 | 2009-10-27 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
US7747332B2 (en) | 2000-05-08 | 2010-06-29 | International Rehabilitative Sciences, Inc. | Electrical stimulation combined with a biologic to increase osteogenesis |
US7875590B2 (en) | 2002-05-17 | 2011-01-25 | Wyeth | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
US8563040B2 (en) | 2002-02-07 | 2013-10-22 | Marfly 2, Lp | Compositions and methods for forming and strengthening bone |
AU2013224728B2 (en) * | 2006-02-07 | 2016-10-20 | Takeda Pharmaceutical Company Limited | Stabilized Compositions of Proteins Having a Free Thiol Moiety |
WO2017012711A1 (en) * | 2015-07-19 | 2017-01-26 | Tracey Lennemann | New use of hyaluronic acid |
US9623090B2 (en) | 2012-03-02 | 2017-04-18 | Shire Human Genetic Therapies, Inc. | Compositions and methods for treating type III gaucher disease |
US10041137B2 (en) | 2000-08-18 | 2018-08-07 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
US11571466B2 (en) | 2009-07-28 | 2023-02-07 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating Gaucher disease |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090098783A (en) * | 2006-09-21 | 2009-09-17 | 토시키 오구로 | Promoter of hard tissue regeneration |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5464440A (en) * | 1992-01-13 | 1995-11-07 | Lucocer Aktiebolag | Porous implant with two sets of pores |
US5470829A (en) * | 1988-11-17 | 1995-11-28 | Prisell; Per | Pharmaceutical preparation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5133755A (en) * | 1986-01-28 | 1992-07-28 | Thm Biomedical, Inc. | Method and apparatus for diodegradable, osteogenic, bone graft substitute device |
JPH02213A (en) * | 1987-10-19 | 1990-01-05 | Taiho Yakuhin Kogyo Kk | Long-acting physiologically active peptide preparation |
JPH04282322A (en) * | 1991-03-08 | 1992-10-07 | Denki Kagaku Kogyo Kk | Bioactive peptide preparation |
US5356629A (en) * | 1991-07-12 | 1994-10-18 | United States Surgical Corporation | Composition for effecting bone repair |
WO1994001483A1 (en) * | 1992-07-02 | 1994-01-20 | Collagen Corporation | Biocompatible polymer conjugates |
-
1997
- 1997-03-05 JP JP53207097A patent/JP2002504083A/en active Pending
- 1997-03-05 CN CNB971928223A patent/CN1149088C/en not_active Expired - Fee Related
- 1997-03-05 EP EP97916976A patent/EP0910389A4/en not_active Withdrawn
- 1997-03-05 WO PCT/US1997/004810 patent/WO1997032591A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5470829A (en) * | 1988-11-17 | 1995-11-28 | Prisell; Per | Pharmaceutical preparation |
US5464440A (en) * | 1992-01-13 | 1995-11-07 | Lucocer Aktiebolag | Porous implant with two sets of pores |
Non-Patent Citations (1)
Title |
---|
See also references of EP0910389A4 * |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0957943B2 (en) † | 1997-02-07 | 2008-11-26 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
JP2009102393A (en) * | 1997-02-07 | 2009-05-14 | Stryker Corp | Matrix-free osteogenic devices, implants and methods of use thereof |
US9254301B2 (en) | 1998-03-30 | 2016-02-09 | Marfly2, LP | Compositions and methods for forming and strengthening bone |
US7157080B2 (en) | 1998-12-21 | 2007-01-02 | Fidia Advanced Biopolymers, Srl. | Injectable hyaluronic acid derivative with pharmaceuticals/cells |
US6699471B2 (en) | 1998-12-21 | 2004-03-02 | Fidia Advanced Biopolymers, Srl | Injectable hyaluronic acid derivative with pharmaceuticals/cells |
US6372257B1 (en) | 1999-06-29 | 2002-04-16 | J. Alexander Marchosky | Compositions and methods for forming and strengthening bone |
EP1203074A4 (en) * | 1999-06-29 | 2003-09-10 | J Alexander Marchosky | Compositions and methods for forming and strengthening bone |
EP1203074A1 (en) * | 1999-06-29 | 2002-05-08 | J. Alexander Marchosky | Compositions and methods for forming and strengthening bone |
EP1198235A4 (en) * | 1999-07-26 | 2006-04-05 | Depuy Spine Inc | Method of promoting bone growth with hyaluronic acid and growth factors |
EP1198235A1 (en) * | 1999-07-26 | 2002-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
JP2009143949A (en) * | 1999-07-26 | 2009-07-02 | Depuy Spine Inc | Method for promoting bone growth by using hyaluronic acid and growth factor |
EP2286847A1 (en) * | 1999-10-15 | 2011-02-23 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
US7608580B2 (en) | 1999-10-15 | 2009-10-27 | Genetics Institute, Llc | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins |
US6831178B2 (en) | 2000-04-19 | 2004-12-14 | Shionogi & Co., Ltd. | Process for preparation of sulfonamide derivatives and crystals thereof |
US7747332B2 (en) | 2000-05-08 | 2010-06-29 | International Rehabilitative Sciences, Inc. | Electrical stimulation combined with a biologic to increase osteogenesis |
US10041137B2 (en) | 2000-08-18 | 2018-08-07 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
EP1731193A1 (en) * | 2001-07-16 | 2006-12-13 | International Rehabilitative Sciences, Inc. | Electro-medical device for use with biologics |
US8563040B2 (en) | 2002-02-07 | 2013-10-22 | Marfly 2, Lp | Compositions and methods for forming and strengthening bone |
US7875590B2 (en) | 2002-05-17 | 2011-01-25 | Wyeth | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
US9072785B2 (en) | 2006-02-07 | 2015-07-07 | Shire Human Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moiety |
WO2007092829A3 (en) * | 2006-02-07 | 2007-10-18 | Shire Human Genetic Therapies | Stabilized compositions of proteins having a free thiol moiety |
TWI415630B (en) * | 2006-02-07 | 2013-11-21 | Shire Human Genetic Therapies | Stabilized compositions of proteins having a free thiol moieyt |
US8673298B2 (en) | 2006-02-07 | 2014-03-18 | Shire Human Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moeity |
US7833766B2 (en) | 2006-02-07 | 2010-11-16 | Shire Human Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moiety |
WO2007092829A2 (en) * | 2006-02-07 | 2007-08-16 | Shire Human Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moiety |
AU2013224728B2 (en) * | 2006-02-07 | 2016-10-20 | Takeda Pharmaceutical Company Limited | Stabilized Compositions of Proteins Having a Free Thiol Moiety |
US9694057B2 (en) | 2006-02-07 | 2017-07-04 | Shire Huma Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moiety |
EP2361613A1 (en) * | 2006-02-07 | 2011-08-31 | Shire Human Genetic Therapies, Inc. | Stabilized compositions of proteins having a free thiol moiety |
US11571466B2 (en) | 2009-07-28 | 2023-02-07 | Takeda Pharmaceutical Company Limited | Compositions and methods for treating Gaucher disease |
US9623090B2 (en) | 2012-03-02 | 2017-04-18 | Shire Human Genetic Therapies, Inc. | Compositions and methods for treating type III gaucher disease |
WO2017012711A1 (en) * | 2015-07-19 | 2017-01-26 | Tracey Lennemann | New use of hyaluronic acid |
US10449214B2 (en) | 2015-07-19 | 2019-10-22 | Tracey Lennemann | Use of hyaluronic acid |
Also Published As
Publication number | Publication date |
---|---|
CN1149088C (en) | 2004-05-12 |
EP0910389A1 (en) | 1999-04-28 |
CN1212628A (en) | 1999-03-31 |
JP2002504083A (en) | 2002-02-05 |
EP0910389A4 (en) | 2001-09-19 |
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