WO1997012859A1 - Succinimide and maleimide cytokine inhibitors - Google Patents
Succinimide and maleimide cytokine inhibitorsInfo
- Publication number
- WO1997012859A1 WO1997012859A1 PCT/US1996/015864 US9615864W WO9712859A1 WO 1997012859 A1 WO1997012859 A1 WO 1997012859A1 US 9615864 W US9615864 W US 9615864W WO 9712859 A1 WO9712859 A1 WO 9712859A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- carbon atoms
- alkyl
- substimted
- phenyl
- amino
- Prior art date
Links
- MDZUCVOITLGYLU-UHFFFAOYSA-N CCOc1cc(C(CC(OC)=O)N(C(C2=C3CCCC2)=O)C3=O)ccc1OC Chemical compound CCOc1cc(C(CC(OC)=O)N(C(C2=C3CCCC2)=O)C3=O)ccc1OC MDZUCVOITLGYLU-UHFFFAOYSA-N 0.000 description 1
- 0 COC(CC(CC1C2CCCCCC2)C(C*=O)N(C(C2C3CC=CC2)=O)C3=O)C1OC Chemical compound COC(CC(CC1C2CCCCCC2)C(C*=O)N(C(C2C3CC=CC2)=O)C3=O)C1OC 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Definitions
- the present invention relates to a method of reducing levels of TNF ⁇ and inhibiting phosphodiesterase in a mammal and to compounds and compositions useful therein.
- TNF ⁇ or tumor necrosis factor ⁇
- TNF ⁇ is a cytokine which is released primarily by mononuclear phagocytes in response to various immunostimulators. When administered to animals or humans it causes inflammation, fever, cardiovascular effects, hemorrhage, coagulation and acute phase responses similar to those seen during acute infections and shock states.
- TNF ⁇ production has been implicated in a number of disease conditions. These include endotoxemia and/or toxic shock syndrome (Tracey et al , Nature 330,
- TNF ⁇ appears to be involved in bone resorption diseases, including arthritis where it has been dete ⁇ nined that when activated, leukocytes will produce a bone-resorbing activity, and data suggests that TNF ⁇ contributes to this activity (Bertolini et al. , Nature 319, 516-518 (1986) and Johnson et al. , Endocrinology 124(3), 1424-1427 (1989)). It has been determined that TNF ⁇ stimulates bone reso ⁇ tion and inhibits bone formation in vitro and in vivo through stimulation of osteoclast formation and activation combined with inhibition of osteoblast function.
- TNF ⁇ may be involved in many bone resorption diseases, including arthritis
- the most compelling link with disease is the association between production of TNF ⁇ by tumor or host tissues and malignancy associated hypercalcemia (Calci. Tissue Int. (US) 46(Suppl.), S3-10 (1990)).
- US Tissue Int.
- graft versus Host Disease increased serum TNF ⁇ levels have been associated with major complications following acute allogenic bone marrow transplants (Holler et al , Blood, 75(4), 1011-1016 (1990)).
- Cerebral malaria is a lethal hyperacute neurological syndrome associated with high blood levels of TNF ⁇ and is the most severe complication occurring in malaria patients. Levels of serum TNF ⁇ correlated directly with the severity of the disease and the prognosis in patients with acute malaria attacks (Grau et al. , N. Engl. J. Med. 320(24), 1586-1591 (1989)).
- TNF ⁇ also plays a role in the area of chronic pulmonary inflammatory diseases.
- the deposition of silica particles leads to silicosis, a disease of progressive respiratory failure caused by a fibrotic reaction.
- Antibodies to TNF ⁇ completely blocked the silica-induced lung fibrosis in mice (Pignet et al , Nature, 344:245-247 (1990)).
- High levels of TNF ⁇ production, in the serum and in isolated macrophages, have been demonstrated in animal models of silica and asbestos induced fibrosis (Bissonnette et al , Inflammation 13(3), 329-339 (1989)).
- TNF ⁇ is also implicated in the inflammatory response which follows reperfusion, called reperfusion injury, and is a major cause of tissue damage after loss of blood flow (Vedder et al. , PNAS 87, 2643-2646 (1990)). TNF ⁇ also alters the properties of endothelial cells and has various pro-coagulant activities, such as producing an increase in tissue factor pro-coagulant activity and suppression of the anticoagulant protein C pathway as well as down-regulating the expression of thrombomodulin (Sherry et al , J. Cell Biol. 107, 1269-1277 (1988)).
- TNF ⁇ has pro-inflammatory activities which together with its early production (during the initial stage of an inflammatory event) make it a likely mediator of tissue injury in several important disorders including but not limited to, myocardial infarction, stroke and circulatory shock. Of specific importance may be TNF ⁇ -induced expression of adhesion molecules, such as intercellular adhesion molecule (ICAM) or endothelial leukocyte adhesion molecule (ELAM) on endothelial cells (Munro et al. , Am. J. Path. 135(1), 121-132 (1989)).
- IAM intercellular adhesion molecule
- ELAM endothelial leukocyte adhesion molecule
- TNF ⁇ is a potent activator of retrovirus replication including activation of HIV-l .
- Duh et al Proc. Nat. Acad. Sci. 86, 5974-5978 (1989); Poll et al, Proc. Nat. Acad. Sci. 87, 782-785 (1990); Monto et al, Blood 79, 2670 (1990); Clouse et al, J. Immunol 142, 431 ⁇ 38 (1989); Poll et al, AIDS Res. Hum. Retrovirus, 191-197 (1992)).
- HIV Human Immunodeficiency Virus
- HIV-l T-cell mediated immunity
- HIV-2 T-cell mediated immunity
- infected individuals manifest severe opportunistic infections and/or unusual neoplasms.
- HIV entry into the T lymphocyte requires T lymphocyte activation.
- Other viruses, such as HIV-l and HIV-2 infect T lymphocytes after T cell activation and such virus protein expression and/or replication is mediated or maintained by such T cell activation.
- the T lymphocyte Once an activated T lymphocyte is infected with HTV, the T lymphocyte must continue to be maintained in an activated state to permit HIV gene expression and/or HIV replication.
- Cytokines are implicated in acti ⁇ vated T-cell mediated HIV protein expression and/or virus replication by playing a role in mamtaining T lymphocyte activation. Therefore, interference with cytokine activity such as by prevention, control, or inhibition of cytokine production, notably TNF ⁇ , in a HlV-infected indi ⁇ vidual aids in limiting the maintenance of T lymphocyte activation caused by HIV infection.
- Monocytes, macrophages, and related cells, such as kupffer and glial cells have also been implicated in maintenance of the HIV infection.
- T cells like T cells, are targets for viral replication and the level of viral replication is dependent upon the activation state of the cells (Rosenberg et al , The Immunopathogenesis of HTV Infection, Advances in Immunology, 57 (1989)).
- Cytokines such as TNF ⁇ , have been shown to activate HIV replication in monocytes and/or macrophages (Poli et al, Proc. Natl. Acad. Sci. , 87, 782-784 (1990)), therefore, prevention, control, or inhibition of cytokine production or activity aids in limiting HIV progression as stated above for T cells.
- TNF ⁇ is a common factor in the activation of HPV in vitro and has provided a clear mechanism of action via a nuclear regulatory protein found in the cytoplasm of cells (Osborn, et al. , PNAS 86, 2336-2340). This evidence suggests that a reduction of TNF ⁇ synthesis may have an antiviral effect in HIV infections, by reducing the transcription and thus virus production.
- HIV viral replication of latent HIV in T cell and macrophage lines can be induced by TNF ⁇ (Folks et al. , PNAS 86, 2365-2368 (1989)).
- TNF ⁇ A molecular mechanism for the virus inducing activity is suggested by TNF ⁇ 's ability to activate a gene regulatory protein (NFKB) found in the cytoplasm of cells, which promotes HIV replication through binding to a viral regulatory gene sequence (LTR) (Osborn et al , PNAS 86, 2336-2340 (1989)).
- TNF ⁇ in AIDS associated cachexia is suggested by elevated serum TNF ⁇ and high levels of spontaneous TNF ⁇ production in peripheral blood monocytes from patients (Wright et al. J. Immunol 141(1), 99-104 (1988)).
- TNF ⁇ has been implicated in various roles with other viral infections, such as the cytomegalia virus (CMV), influenza virus, adenovirus, and the herpes family of viruses for similar reasons as those noted.
- CMV cytomegalia virus
- influenza virus influenza virus
- adenovirus adenovirus
- herpes family of viruses for similar reasons as those noted.
- TNF ⁇ inflammatory, infectious, immunological or malignant diseases.
- diseases include but are not restricted to septic shock, sepsis, endotoxic shock, hemodynamic shock and sepsis syndrome, post ischemic reperfusion injury, malaria, mycobacterial infection, meningitis, psoriasis, congestive heart failure, fibrotic disease, cachexia, graft rejection, cancer, autoimmune disease, opportunistic infections in AIDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, other arthritic conditions, Crohn's disease, ulcerative colitis, multiple sclerosis, systemic lupus erythrematosis, ENL in leprosy, radiation damage, asthma, and hyperoxic alveolar injury.
- NFKB nuclear factor KB
- NFKB nuclear factor KB
- NFKB has been implicated as a transcriptional activator in a variety of disease and inflammatory states and is thought to regulate cytokine levels including but not limited to TNF ⁇ and also to be an activator of HIV transcription (Dbaibo, et al. J. Biol. Chem. 1993,
- the compounds claimed in this patent can inhibit the action of NFKB in the nucleus and thus are useful in the treatment of a variety of diseases including but not limited to asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, other arthritic conditions, septic shock, septis, endotoxic shock, graft versus host disease, wasting, Crohn's disease, ulcerative colitis, multiple sclerosis, systemic lupus erythrematosis, ENL in leprosy, HIV, AIDS, and opportunistic infections in AIDS.
- diseases including but not limited to asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, other arthritic conditions, septic shock, septis, endotoxic shock, graft versus host disease, wasting, Crohn's disease, ulcerative colitis, multiple sclerosis, systemic lupus erythrematos
- TNF ⁇ and NFKB levels are influenced by a reciprocal feedback loop.
- the compounds of the present invention affect the levels of both TNF ⁇ and NFKB. It is not known at this time, however, how the compounds of the present invention regulate the levels of TNF ⁇ , NFKB, or both.
- Many cellular functions can be mediated by levels of adenosine 3' ,5'-cyclic monophosphate(cAMP). Such cellular functions can contribute to inflammatory conditions and diseases including asthma, inflammation, and other conditions (Lowe and Cheng, Drugs of the Future, 17(9), 799-807, 1992). It has been shown that the elevation of cAMP in inflammatory leukocytes inhibits their activation and the subsequent release of inflammatory mediators.
- PDE cyclic nucleotide phosphodiesterases
- the compounds of the present invention are useful in the inhibition of phosphodiesterases, particularly PDE LH and PDE FV, and in the treatment of disease states mediated thereby.
- the present invention is based on the discovery that a class of non-polypeptide imides more fully described herein appear to inhibit the action of TNF ⁇ .
- the present invention pertains to compounds of the formula:
- R 1 is -CH 2 -, -CH 2 CO-, or -CO-;
- R 2 and R 3 taken together are (i) ethylene unsubstituted or substituted with one or more alkyl of 1 - 10 carbon atoms or phenyl, (ii) vinylene substituted with two substituents each selected, independently of the other, from the group consisting of alkyl of 1 - 10 carbon atoms and phenyl, or (iii) a divalent cycloalkyl or bicyclic alkyl of 5 - 10 carbon atoms, unsubstituted or substituted with one or more substituents each selected independently of the other from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl unsubstituted or substituted with alkyl of 1 -3 carbon atoms, acetoxy, carboxy, hydroxy, amino, substituted amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, nor
- R 4 is a (i) straight or branched unsubstituted alkyl of 4 to 8 carbon atoms; (ii) cycloalkyl of 5 - 10 carbon atoms, unsubstituted or substituted with one or more substituents each selected independently of the other from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, substituted amino, branched, straight or cyclic alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, phenyl or halo; (iii) phenyl substituted with one or more substituents each selected independently of the other from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carb
- R 5 is -COX, -CN, -CH 2 COX, alkyl of 1 to 5 carbon atoms, aryl,-CH 2 OR, -CH 2 aryl, or
- alkyl denotes a univalent saturated branched or straight hydrocarbon chain. Unless otherwise stated, such chains can contain from 1 to 18 carbon atoms.
- Representative of such alkyl groups are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec- butyl, tert-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, isohexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, and the like.
- alkyl group When qualified by "lower", the alkyl group will contain from 1 to 6 carbon atoms. The same carbon content applies to the parent term “alkane” and to derivative terms such as “alkoxy”.
- cycloalkyl groups are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, cycloundecyl, cyclododecyl, cyclotridecyl, cyclotetradecyl, cyclopentadecyl, cyclohexadecyl, cycloheptadecyl, cyclooctadecyl, cyclic terpenes, and the like.
- the cycloalkyl group will contain from 3 to 6 carbon atoms. The same carbon content applies to the parent term "cycloalkane” and to derivative terms such as "cycloalkoxy”.
- substituted amino denotes a univalent amine with one or two substituents each selected independently of the other from the group consisting of nitro, cyano, trifluoromethyl, carbethoxy, carbomethoxy, carbopropoxy, acetyl, carbamoyl, acetoxy, carboxy, hydroxy, amino, alkyl of 1 to 10 carbon atoms, alkoxy of 1 to 10 carbon atoms, or phenyl.
- Typical compounds of this invention include: Methyl 3-succinimidyl-(3 ,4-dimethoxyphenyl)propionate, Methyl 3-succi ⁇ imidyl-(3-ethoxy-4-methoxyphenyl)propionate, Methyl 3-succinimidyl-(3-cyclopentoxy-4-methoxyphenyl)propionate, Ethyl 3-succinimidyl-(3,4-diethoxyphenyl)propionate,
- a first preferred subclass pertains to compounds in which R 4 is aryl and R 5 is CH 2 CO 2 CH 3
- the compounds can be used, under the supervision of qualified professionals, to inhibit the undesirable effects of TNF ⁇ .
- the compounds can be administered orally, rectally, or parenterally, alone or in combination with other therapeutic agents including antibiotics, steroids, etc., to a mammal in need of treatment.
- Oral dosage forms include tablets, capsules, dragees, and similar shaped, compressed pharmaceutical forms.
- Isotonic saline solutions containing 20-100 milligrams/milliliter can be used for parenteral administration which includes intramuscular, intrathecal, intravenous and intra-arterial routes of administration. Rectal administration can be effected through the use of suppositories formulated from conventional carriers such as cocoa butter.
- Dosage regimens must be titrated to the particular indication, the age, weight, and general physical condition of the patient, and the response desired, but generally doses will be from about 1 to about 500 milligrams/day as needed in single or multiple daily administration.
- an initial treatment regimen can be copied from that known to be effective in interfering with TNF ⁇ activity for other TNF ⁇ mediated disease states by the compounds of the present invention.
- Treated individuals will be regularly checked for T cell numbers and T4/T8 ratios and/or measures of viremia such as levels of reverse transcriptase or viral proteins, and/or for progression of cytokine-mediated disease associated problems such as cachexia or muscle degeneration. If no effect is seen following the normal treatment regimen, then the amount of cytokine activity interfering agent administered is increased, e.g. , by fifty percent a week.
- the compounds of the present invention can also be used topically in the treatment or prophylaxis of topical disease states mediated or exacerbated by excessive TNF ⁇ production, such as viral infections, for example those caused by the herpes viruses, or viral conjunctivitis, etc.
- the compounds can also be used in the veterinary treatment of mammals other than humans in need of prevention or inhibition of TNF ⁇ production.
- TNF ⁇ mediated diseases for treatment, therapeutically or prophylactically, in animals include disease states such as those noted above, but in particular viral infections. Examples include feline immunodeficiency virus, equine infectious anaemia virus, caprine arthritis virus, visna virus, and maedi virus, as well as other lentiviruses.
- racemates of these isomers possess centers of chirality and can exist as optical isomers. Both the racemates of these isomers and the individual isomers themselves, as well as diastereoisomers when there are two chiral centers, are within the scope of the present invention.
- the racemates can be used as such or can be separated into their individual isomers mechanically as by chromatography using a chiral absorbent.
- the individual isomers can be prepared in chiral form or separated chemically from a mixture by forming salts with a chiral acid, such as the individual enantiomers of 10-camphorsulfonic acid, camphoric acid, alpha-bromocamphoric acid, methoxyacetic acid, tartaric acid, diacetyltartaric acid, malic acid, pyrrolidone-5-carboxylic acid, and the like, and then freeing one or both of the resolved bases, optionally repeating the process, so as to obtain either or both substantially free of the other; i.e., in a form having an optical purity of > 95 % .
- a chiral acid such as the individual enantiomers of 10-camphorsulfonic acid, camphoric acid, alpha-bromocamphoric acid, methoxyacetic acid, tartaric acid, diacetyltartaric acid, malic acid, pyrrolidone-5-carboxylic acid, and the like
- TNF ⁇ Inhibition Assays in LPS stimulated PBMC have been performed as follows:
- PBMC isolation PBMC from normal donors were obtained by Ficoll-Hypaque density centrifugation. Cells were cultured in RPMI supplemented with 10% AB + serum, 2mM L-glutamine, 100 U/mL penicillin and 100 ⁇ g/mL streptomycin.
- PBMC suspensions Drugs were dissolved in DMSO (Sigma Chemical), further dilutions were done in supplemented RPMI. The final DMSO concentration in the presence or absence of drug in the PBMC suspensions was 0.25 wt % . Drugs were assayed at half-log dilutions starting at 50 ⁇ g/mL. Drugs were added to PBMC (10° cells/mL) in 96 wells plates one hour before the addition of LPS. Cell stimulation: PBMC (10° cells/mL) in the presence- or absence of drug were stimulated by treatment with 1 ⁇ g/mL of LPS from Salmonella minnesota R595 (List Biological Labs, Campbell, CA). Cells were then incubated at 37 °C for 18-20 hours. Supernatants were then harvested and assayed immediately for TNF ⁇ levels or kept frozen at -70 °C (for not more than 4 days) until assayed.
- DMSO Sigma Chemical
- the mixture was extracted into ether (25 mL) and was washed successively with a saturated aqueous solution of sodium bicarbonate (25 mL), brine (10 mL), sodium bicarbonate (25 mL) and brine (10 mL).
- the ether layer was dried over magnesium sulfate and concentrated in vacuo to afford 0.36 grams of crude product as a brown oil.
- Example 8 Tablets each containing 50 milligrams of active ingredient, can be prepared in the following manner:
- active ingredient 50.0 grams lactose 50.7 grams wheat starch 7.5 grams polyethylene glycol 6000 5.0 grams talc 5.0 grams magnesium stearate 1.8 grams demineralized water q.s.
- the solid ingredients are first forced through a sieve of 0.6 mm mesh width.
- the active ingredient, the lactose, the talc, the magnesium stearate and half of the starch are then mixed.
- the other half of the starch is suspended in 40 milliliters of water and this suspension is added to a boiling solution of the polyethylene glycol in 100 milliliters of water.
- the resulting paste is added to the pulverulent substances and the mixmre is granulated, if necessary with the addition of water.
- the granulate is dried overnight at 35 °C, forced through a sieve of 1.2 mm mesh width and compressed to form tablets of approximately 6 mm diameter which are concave on both sides.
- Tablets each containing 100 milligrams of active ingredient, can be prepared in the following manner: Constituents (for 1000 tablets) active ingredient 100.0 grams lactose 100.0 grams wheat starch 47.0 grams magnesium stearate 3.0 grams
- All the solid ingredients are first forced through a sieve of 0.6 mm mesh width.
- the active ingredient, the lactose, the magnesium stearate and half of the starch are then mixed.
- the other half of the starch is suspended in 40 milliliters of water and this suspension is added to 100 milliliters of boiling water.
- the resulting paste is added to the pulverulent substances and the mixture is granulated, if necessary with the addition of water.
- the granulate is dried overnight at 35 °C, forced through a sieve of 1.2 mm mesh width and compressed to form tablets of approximately 6 mm diameter which are concave on both sides.
- Tablets for chewing each containing 75 milligrams of active ingredient, can be prepared in the following manner: Composition (for 1000 tablets) active ingredient 75.0 grams mannitol 230.0 grams lactose 150.0 grams talc 21.0 grams glycine 12.5 grams stearic acid 10.0 grams saccharin 1.5 grams
- All the solid ingredients are first forced through a sieve of 0.25 mm mesh width.
- the mannitol and the lactose are mixed, granulated with the addition of gelatin solution, forced through a sieve of 2 mm mesh width, dried at 50°C and again forced through a sieve of 1.7 mm mesh width.
- the active ingredient, the glycine and the saccharin are carefully mixed, the mannitol, the lactose granulate, the stearic acid and the talc are added and the whole is mixed thoroughly and compressed to form tablets of approximately 10 mm diameter which are concave on both sides and have a breaking groove on the upper side.
- Example 11 Tablets each containing 10 milligrams of active ingredient, can be prepared in the following manner:
- composition for 1000 tablets
- active ingredient 10.0 grams lactose 328.5 grams corn starch 17.5 grams polyethylene glycol 6000 5.0 grams talc 25.0 grams magnesium stearate 4.0 grams demineralized water q.s.
- the solid ingredients are first forced through a sieve of 0.6 mm mesh width. Then the active ingredient, lactose, talc, magnesium stearate and half of the starch are intimately mixed. The other half of the starch is suspended in 65 milliliters of water and this suspension is added to a boiling solution of the polyethylene glycol in 260 milliliters of water. The resulting paste is added to the pulverulent substances, and the whole is mixed and granulated, if necessary with the addition of water. The granulate is dried overnight at 35 °C, forced through a sieve of 1.2 mm mesh width and compressed to form tablets of approximately 10 mm diameter which are concave on both sides and have a breaking notch on the upper side.
- Gelatin dry-filled capsules each containing 100 milligrams of active ingredient, can be prepared in the following manner: Composition (for 1000 capsules) active ingredient 100.0 grams microcrystalline cellulose 30.0 grams sodium lauryl sulphate 2.0 grams magnesium stearate 8.0 grams
- the sodium lauryl sulphate is sieved into the active ingredient through a sieve of 0.2 mm mesh width and the two components are intimately mixed for 10 minutes.
- the microcrystalline cellulose is then added through a sieve of 0.9 mm mesh width and the whole is again intimately mixed for 10 minutes.
- the magnesium stearate is added through a sieve of 0.8 mm width and, after mixing for a further 3 minutes, the mixmre is introduced in portions of 140 milligrams each into size 0 (elongated) gelatin dry-fill capsules.
- a 0.2% injection or infusion solution or suspension can be prepared, for example, in the following manner: active ingredient 5.0 grams sodium chloride 22.5 grams phosphate buffer pH 7.4 300.0 grams demineralized water to 2500.0 milliliters
- the active ingredient is dissolved in 1000 milliliters of water and filtered through a microfilter or slurried in 1000 milliliters of water.
- the buffer solution is added and the whole is made up to 2500 milliliters with water.
- portions of 1.0 or 2.5 milliliters each are introduced into glass ampules (each containing respectively 2.0 or 5.0 milligrams of active ingredient).
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69629716T DE69629716T2 (en) | 1995-10-06 | 1996-10-04 | SUCCINIMID AND MALEIMID CYTOKIN INHIBITORS |
AU73873/96A AU723915B2 (en) | 1995-10-06 | 1996-10-04 | Succinimide and maleimide cytokine inhibitors |
KR1019980702531A KR100345826B1 (en) | 1995-10-06 | 1996-10-04 | Succinimide and maleimide cytokine inhibitors |
CA002233975A CA2233975C (en) | 1995-10-06 | 1996-10-04 | Succinimide and maleimide cytokine inhibitors |
NZ321001A NZ321001A (en) | 1995-10-06 | 1996-10-04 | 3-maleimido- or 3-(phthalimido)-3-(3,4-disubstituted phenyl)propionate derivatives useful as cytokine inhibitors |
EP96936155A EP0862552B1 (en) | 1995-10-06 | 1996-10-04 | Succinimide and maleimide cytokine inhibitors |
SK446-98A SK44698A3 (en) | 1995-10-06 | 1996-10-04 | Succinimide and maleimide cytokine inhibitors |
AT96936155T ATE248145T1 (en) | 1995-10-06 | 1996-10-04 | SUCCINIMIDE AND MALEIMIDE CYTOKINE INHIBITORS |
FI980776A FI119690B (en) | 1995-10-06 | 1998-04-03 | Succinimide and maleinimide cytokine inhibitors |
HK99100926A HK1017885A1 (en) | 1995-10-06 | 1999-03-08 | Succinimide and maleimide cytokine inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/539,879 US5658940A (en) | 1995-10-06 | 1995-10-06 | Succinimide and maleimide cytokine inhibitors |
US08/539,879 | 1995-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997012859A1 true WO1997012859A1 (en) | 1997-04-10 |
Family
ID=24153040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/015864 WO1997012859A1 (en) | 1995-10-06 | 1996-10-04 | Succinimide and maleimide cytokine inhibitors |
Country Status (19)
Country | Link |
---|---|
US (1) | US5658940A (en) |
EP (1) | EP0862552B1 (en) |
JP (1) | JP3226546B2 (en) |
KR (1) | KR100345826B1 (en) |
AT (1) | ATE248145T1 (en) |
AU (1) | AU723915B2 (en) |
CA (1) | CA2233975C (en) |
CZ (1) | CZ105398A3 (en) |
DE (1) | DE69629716T2 (en) |
ES (1) | ES2206600T3 (en) |
FI (1) | FI119690B (en) |
HK (1) | HK1017885A1 (en) |
HU (1) | HUP9902034A3 (en) |
NZ (1) | NZ321001A (en) |
PL (1) | PL326063A1 (en) |
PT (1) | PT862552E (en) |
RU (1) | RU2176242C2 (en) |
SK (1) | SK44698A3 (en) |
WO (1) | WO1997012859A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6429221B1 (en) * | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
US5801195A (en) | 1994-12-30 | 1998-09-01 | Celgene Corporation | Immunotherapeutic aryl amides |
US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
KR100539031B1 (en) * | 1996-08-12 | 2005-12-27 | 셀진 코포레이션 | Novel immunotherapeutic agents and their use in the reduction of cytokine levels |
US6020358A (en) * | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
AU2006200033B8 (en) * | 1998-10-30 | 2008-09-11 | Celgene Corporation | Substituted phenethylsulfones and methods of reducing TNF-alpha levels |
US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
AU6108300A (en) * | 1999-07-15 | 2001-02-05 | Cytoclonal Pharmaceutics, Inc. | Method of designing tubulin polymerization stabilizers |
US6667316B1 (en) | 1999-11-12 | 2003-12-23 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
US7182953B2 (en) | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
US6326388B1 (en) | 1999-12-21 | 2001-12-04 | Celgene Corporation | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level |
US6699899B1 (en) | 1999-12-21 | 2004-03-02 | Celgene Corporation | Substituted acylhydroxamic acids and method of reducing TNFα levels |
US20010051348A1 (en) * | 2000-01-28 | 2001-12-13 | Lee Chee Wee | Novel ligands and methods for preparing same |
US8030343B2 (en) * | 2000-06-08 | 2011-10-04 | Celgene Corporation | Pharmaceutically active isoindoline derivatives |
US7491634B2 (en) * | 2006-04-28 | 2009-02-17 | Asm International N.V. | Methods for forming roughened surfaces and applications thereof |
GB0125658D0 (en) * | 2001-10-25 | 2001-12-19 | Ssl Int Plc | Medicaments |
US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
US7893101B2 (en) * | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
KR20050000398A (en) * | 2002-04-12 | 2005-01-03 | 셀진 코포레이션 | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
CA2481385A1 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
KR101059041B1 (en) | 2002-05-17 | 2011-08-24 | 셀진 코포레이션 | Methods and compositions for using selective cytokine inhibitory drugs for the treatment and treatment of cancer and other diseases |
US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
EP1556049A1 (en) * | 2002-08-10 | 2005-07-27 | ALTANA Pharma AG | Piperidine-pyridazones and phthalazones as pde4 inhibitors |
US6774758B2 (en) * | 2002-09-11 | 2004-08-10 | Kalyan P. Gokhale | Low harmonic rectifier circuit |
JP2006510606A (en) * | 2002-10-15 | 2006-03-30 | セルジーン・コーポレーション | Methods of using selective cytokine inhibitors for treating and managing myelodysplastic syndrome and compositions comprising the same |
US20040087558A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
US7776907B2 (en) * | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
AU2003226361B2 (en) * | 2002-11-06 | 2009-01-22 | Celgene Corporation | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
TW200501945A (en) | 2002-11-06 | 2005-01-16 | Celgene Corp | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
US20040167199A1 (en) * | 2002-11-18 | 2004-08-26 | Celgene Corporation | Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
AU2003294311B8 (en) * | 2002-11-18 | 2008-06-05 | Celgene Corporation | Method of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
WO2005051942A1 (en) | 2003-11-19 | 2005-06-09 | Signal Pharmaceuticals, Llc | Indazole compounds and methods of use thereof as protein kinase inhibitors |
JP2007532642A (en) * | 2004-04-14 | 2007-11-15 | セルジーン・コーポレーション | Use of selective cytokine inhibitors for the treatment and management of myelodysplastic syndromes and compositions containing the same |
CA2563377A1 (en) * | 2004-04-23 | 2005-11-03 | Celgene Corporation | Methods of using and compositions comprising pde4 modulators for the treatment and management of pulmonary hypertension |
US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
US20070190070A1 (en) * | 2004-09-03 | 2007-08-16 | Zeldis Jerome B | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of disorders of the central nervous system |
MX2007005040A (en) * | 2004-10-28 | 2007-06-19 | Celgene Corp | Methods and compositions using pde4 modulators for treatment and management of central nervous system injury. |
US20080138295A1 (en) * | 2005-09-12 | 2008-06-12 | Celgene Coporation | Bechet's disease using cyclopropyl-N-carboxamide |
AU2006314062A1 (en) * | 2005-11-21 | 2007-05-24 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
US8853257B2 (en) | 2005-11-21 | 2014-10-07 | Mordechai Sharir | Succinimide derivatives as ocular hypotensive agents |
US20070155791A1 (en) * | 2005-12-29 | 2007-07-05 | Zeldis Jerome B | Methods for treating cutaneous lupus using aminoisoindoline compounds |
NZ582096A (en) * | 2007-06-29 | 2012-05-25 | Gilead Sciences Inc | Antiviral compounds that inhibit hepatitis c virus (hcv) |
CA2718412A1 (en) * | 2008-03-24 | 2009-10-01 | Celgene Corporation | Treatment of psoriasis or psoriatic arthritis using cyclopropyl-n-{2-{(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
US8092822B2 (en) * | 2008-09-29 | 2012-01-10 | Abbott Cardiovascular Systems Inc. | Coatings including dexamethasone derivatives and analogs and olimus drugs |
EP2395995A1 (en) | 2009-02-10 | 2011-12-21 | Celgene Corporation | Methods of using and compositions comprising pde4 modulators for treatment, prevention and management of tuberculosis |
MX341050B (en) | 2010-04-07 | 2016-08-05 | Celgene Corp * | Methods for treating respiratory viral infection. |
ES2692152T3 (en) | 2010-06-15 | 2018-11-30 | Celgene Corporation | Biomarkers for the treatment of psoriasis |
CN103788076B (en) * | 2014-01-22 | 2015-06-03 | 山西大学 | Reagent and method for detecting cysteine |
WO2015175956A1 (en) | 2014-05-16 | 2015-11-19 | Celgene Corporation | Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators |
EP3157520B1 (en) | 2014-06-23 | 2019-09-04 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
WO2017070291A1 (en) | 2015-10-21 | 2017-04-27 | Celgene Corporation | Pde4 modulators for treating and preventing immune reconstitution inflammatory syndrome (iris) |
US20190292463A1 (en) * | 2016-06-03 | 2019-09-26 | Jnc Corporation | Polymerizable polar compound, liquid crystal composition, and liquid crystal display element |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2852526A (en) * | 1955-05-03 | 1958-09-16 | Schering Corp | Substituted pyrrolidines |
US4162325A (en) * | 1976-10-22 | 1979-07-24 | Ucb, Societe Anonyme | N-substituted lactams |
GB2015521A (en) * | 1978-03-02 | 1979-09-12 | Philagro Sa | Pyrrolidin-2-one derivatives |
US4394369A (en) * | 1982-05-24 | 1983-07-19 | Fmc Corporation | Hydrogen peroxide process |
WO1989011275A1 (en) * | 1988-05-27 | 1989-11-30 | Nelson Research & Development Co. | Penetration enhancers for transdermal delivery of systemic agents |
EP0462061A1 (en) * | 1990-06-13 | 1991-12-18 | Ciba-Geigy Ag | Triazole compounds useful as metal deactivators |
WO1992014455A1 (en) * | 1991-02-14 | 1992-09-03 | The Rockefeller University | METHOD FOR CONTROLLING ABNORMAL CONCENTRATION TNF α IN HUMAN TISSUES |
WO1992019594A1 (en) * | 1991-05-02 | 1992-11-12 | Smithkline Beecham Corporation | Pyrrolidinones |
US5204366A (en) * | 1991-06-10 | 1993-04-20 | American Cyanamid Company | 2,5-dioxo-3-pyrroline-1-acetanilide fungicidal agents, compositions and method for use thereof |
WO1995001348A2 (en) * | 1993-07-02 | 1995-01-12 | Celgene Corporation | Imides as inhibitors of tnp alpha |
WO1996020705A1 (en) * | 1994-12-30 | 1996-07-11 | Celgene Corporation | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a) |
-
1995
- 1995-10-06 US US08/539,879 patent/US5658940A/en not_active Expired - Lifetime
-
1996
- 1996-10-04 NZ NZ321001A patent/NZ321001A/en not_active IP Right Cessation
- 1996-10-04 WO PCT/US1996/015864 patent/WO1997012859A1/en active IP Right Grant
- 1996-10-04 JP JP51442097A patent/JP3226546B2/en not_active Expired - Fee Related
- 1996-10-04 PT PT96936155T patent/PT862552E/en unknown
- 1996-10-04 KR KR1019980702531A patent/KR100345826B1/en not_active IP Right Cessation
- 1996-10-04 SK SK446-98A patent/SK44698A3/en unknown
- 1996-10-04 AT AT96936155T patent/ATE248145T1/en not_active IP Right Cessation
- 1996-10-04 EP EP96936155A patent/EP0862552B1/en not_active Expired - Lifetime
- 1996-10-04 CA CA002233975A patent/CA2233975C/en not_active Expired - Fee Related
- 1996-10-04 AU AU73873/96A patent/AU723915B2/en not_active Ceased
- 1996-10-04 HU HU9902034A patent/HUP9902034A3/en unknown
- 1996-10-04 CZ CZ981053A patent/CZ105398A3/en unknown
- 1996-10-04 PL PL96326063A patent/PL326063A1/en unknown
- 1996-10-04 ES ES96936155T patent/ES2206600T3/en not_active Expired - Lifetime
- 1996-10-04 DE DE69629716T patent/DE69629716T2/en not_active Expired - Lifetime
- 1996-10-04 RU RU98108602/04A patent/RU2176242C2/en not_active IP Right Cessation
-
1998
- 1998-04-03 FI FI980776A patent/FI119690B/en active IP Right Grant
-
1999
- 1999-03-08 HK HK99100926A patent/HK1017885A1/en not_active IP Right Cessation
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2852526A (en) * | 1955-05-03 | 1958-09-16 | Schering Corp | Substituted pyrrolidines |
US4162325A (en) * | 1976-10-22 | 1979-07-24 | Ucb, Societe Anonyme | N-substituted lactams |
GB2015521A (en) * | 1978-03-02 | 1979-09-12 | Philagro Sa | Pyrrolidin-2-one derivatives |
US4394369A (en) * | 1982-05-24 | 1983-07-19 | Fmc Corporation | Hydrogen peroxide process |
WO1989011275A1 (en) * | 1988-05-27 | 1989-11-30 | Nelson Research & Development Co. | Penetration enhancers for transdermal delivery of systemic agents |
EP0462061A1 (en) * | 1990-06-13 | 1991-12-18 | Ciba-Geigy Ag | Triazole compounds useful as metal deactivators |
WO1992014455A1 (en) * | 1991-02-14 | 1992-09-03 | The Rockefeller University | METHOD FOR CONTROLLING ABNORMAL CONCENTRATION TNF α IN HUMAN TISSUES |
WO1992019594A1 (en) * | 1991-05-02 | 1992-11-12 | Smithkline Beecham Corporation | Pyrrolidinones |
US5204366A (en) * | 1991-06-10 | 1993-04-20 | American Cyanamid Company | 2,5-dioxo-3-pyrroline-1-acetanilide fungicidal agents, compositions and method for use thereof |
WO1995001348A2 (en) * | 1993-07-02 | 1995-01-12 | Celgene Corporation | Imides as inhibitors of tnp alpha |
WO1996020705A1 (en) * | 1994-12-30 | 1996-07-11 | Celgene Corporation | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a) |
Non-Patent Citations (11)
Title |
---|
AHMED ET AL.: "A reductive amination/lactamization ...", SYNLETT, vol. 1, 1994, pages 81 - 83, XP002023010 * |
CHEMICAL ABSTRACTS, vol. 101, no. 25, 1984, Columbus, Ohio, US; abstract no. 230442d, KOBAYASHI ET AL.: "Studies on the synthesis of antiulcer agents" XP002023012 * |
CHEMICAL ABSTRACTS, vol. 103, no. 25, 1985, Columbus, Ohio, US; abstract no. 213154j, IHARA INDUSTRY CO.: "N-Substituted benzylmaleimide derivatives" XP002023016 * |
CHEMICAL ABSTRACTS, vol. 118, no. 11, 1993, Columbus, Ohio, US; abstract no. 101797a, TAKAGI ET AL.: "Preparation of N-substituted maleimides ..." XP002023015 * |
CHEMICAL ABSTRACTS, vol. 54, no. 6, 1960, Columbus, Ohio, US; abstract no. 5425, YANAGI: "Reactions of N-vinylimides with amines" XP002023017 * |
CHEMICAL ABSTRACTS, vol. 70, no. 9, 1969, Columbus, Ohio, US; abstract no. 36930n, LA MANNA ET AL.: "Optical rotaroy dispersion studies..." XP002023013 * |
CHEMICAL ABSTRACTS, vol. 85, no. 21, 1976, Columbus, Ohio, US; abstract no. 159870k, ICHIKAWA ET AL.: "2-(2-oxo-1-pyrrolidinyl)phenylacetic acids" XP002023014 * |
CHEMICAL ABSTRACTS, vol. 85, no. 23, 1976, Columbus, Ohio, US; abstract no. 176422h, GHISLANDI ET AL.: "Circular dichromism of imide ..." XP002023011 * |
GARNER ET AL.: "The asymmetric synthesis of ...", J.AM.CHEM.SOC., vol. 115, no. 23, 1993, pages 10742 - 10753, XP002023007 * |
KATRITZKI ET AL.: "o-(alpha-benzotriazolylalkyl)phenols:..", SYNTHESIS, vol. 8, 1992, pages 761 - 764, XP002023009 * |
ROTH ET AL.: "Amidoalkylation of aromatics with ...", TETRAHEDRON, vol. 51, no. 3, - 1995, pages 801 - 810, XP002023008 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US7576104B2 (en) | 2000-12-27 | 2009-08-18 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US8012997B2 (en) | 2000-12-27 | 2011-09-06 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
US8889411B2 (en) | 2002-04-12 | 2014-11-18 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
ATE248145T1 (en) | 2003-09-15 |
FI119690B (en) | 2009-02-13 |
CA2233975A1 (en) | 1997-04-10 |
EP0862552B1 (en) | 2003-08-27 |
JP3226546B2 (en) | 2001-11-05 |
RU2176242C2 (en) | 2001-11-27 |
JPH11513387A (en) | 1999-11-16 |
DE69629716D1 (en) | 2003-10-02 |
AU7387396A (en) | 1997-04-28 |
DE69629716T2 (en) | 2004-07-08 |
SK44698A3 (en) | 1998-09-09 |
FI980776A0 (en) | 1998-04-03 |
EP0862552A1 (en) | 1998-09-09 |
CZ105398A3 (en) | 1998-07-15 |
AU723915B2 (en) | 2000-09-07 |
HK1017885A1 (en) | 1999-12-03 |
ES2206600T3 (en) | 2004-05-16 |
KR100345826B1 (en) | 2002-11-18 |
PT862552E (en) | 2003-12-31 |
KR19990064052A (en) | 1999-07-26 |
HUP9902034A3 (en) | 2001-01-29 |
NZ321001A (en) | 2001-03-30 |
PL326063A1 (en) | 1998-08-17 |
HUP9902034A2 (en) | 1999-11-29 |
US5658940A (en) | 1997-08-19 |
CA2233975C (en) | 2005-12-06 |
FI980776A (en) | 1998-06-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0862552B1 (en) | Succinimide and maleimide cytokine inhibitors | |
US5728845A (en) | Immunotherapeutic nitriles | |
AU717100B2 (en) | Novel immunotherapeutic aryl amides | |
US5728844A (en) | Immunotherapeutic agents | |
AU709719B2 (en) | Substituted imides as TNF inhibitors | |
EP0942902A2 (en) | Novel immunotherapeutic imides/amides | |
EP0797437B1 (en) | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNFalpha | |
NZ536287A (en) | Use of succinimide and maleimide cytokine inhibitors to reduce the levels of TNF in a mammal |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2233975 Country of ref document: CA Kind code of ref document: A Ref document number: 2233975 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 980776 Country of ref document: FI |
|
ENP | Entry into the national phase |
Ref document number: 1997 514420 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 321001 Country of ref document: NZ Ref document number: PV1998-1053 Country of ref document: CZ Ref document number: 1019980702531 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 44698 Country of ref document: SK |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1996936155 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: PV1998-1053 Country of ref document: CZ |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1996936155 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1019980702531 Country of ref document: KR |
|
WWG | Wipo information: grant in national office |
Ref document number: 1019980702531 Country of ref document: KR |
|
WWR | Wipo information: refused in national office |
Ref document number: PV1998-1053 Country of ref document: CZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 1996936155 Country of ref document: EP |