WO1997003718A1 - Transcorneales arzneimittelfreigabesystem - Google Patents
Transcorneales arzneimittelfreigabesystem Download PDFInfo
- Publication number
- WO1997003718A1 WO1997003718A1 PCT/EP1996/003090 EP9603090W WO9703718A1 WO 1997003718 A1 WO1997003718 A1 WO 1997003718A1 EP 9603090 W EP9603090 W EP 9603090W WO 9703718 A1 WO9703718 A1 WO 9703718A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- micro
- spikes
- transcomeal
- reservoir
- spike
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
Definitions
- the present invention relates to a new drug release system for the controlled delivery of drugs over a longer period of time.
- a transcomeal system for the controlled delivery of medicaments bypassing the gastrointestinal tract which essentially consists of a device which enables a medicament to be administered over a longer period of time bypassing the corneal skin layers.
- the device according to the invention essentially consists of a reservoir for the medicament and at least one - typically several - micro-spikes provided with capillary openings, which are connected to the reservoir in such a way that the medicament reaches the micro-spines in the form of an active substance-containing solution from the reservoir.
- the transcomeal system When the transcomeal system is placed on the skin, the stratum corneum and possibly the epidermis are penetrated by the micro-spikes, so that there is direct access to the innervated skin layer.
- the medicinal product can get from the reservoir through the capillary openings of the micro-spikes to vascularized sections of the skin, in order to be absorbed into the bloodstream via the capillary circulatory system.
- micro-cutting edges can also be used, which then scratch the skin when the system is put on.
- a major advantage of the system according to the invention is that the main barrier for transdermally applied drugs - the stratum corneum - is bypassed in the system according to the invention. It is precisely the individually different properties of the top homolayer in patients that cause transdermal application of active substances to cause problems such as a lack of bioavailability and allergies.
- a particular advantage of trancorneal application is that this type of application is not limited to those active ingredients that penetrate through the skin, as is the case, for example, with transdermal application. Suitable active ingredients
- ORIGINAL DOCUMENTS are for example pain relievers - such as B. morphine, naltrexone, fentanyl, oxymorphone; anti-Parkinson agents - such as L-dopa, pramipexole; Cardiovascular agents, nitroglycerin, anti-hypertensive agents and vasodilatory diseases such as clonidine, nifidepine, verapamil, diltiazam; Anticoagulants such as heparin, hirudin; Long-term therapy for cancer and immune diseases; Long-term treatment agents in addiction therapy; Peptides; ACE inhibitors; Neurokine antagonists; Hormones - such as oestradiol.
- the active ingredient is usually in the form of a solution in order to ensure proper transport through the capillary openings of the micro-spines of the transcomeal system.
- all physiologically compatible solvents or solvent mixtures in which the active ingredient dissolves in a sufficient amount can be used.
- a sufficient amount is understood to mean those concentrations of active ingredient in the solvent which make it possible to apply a therapeutically effective amount of active ingredient.
- Preferred solvents are water and ethanol. If necessary, solubilizers and complexing agents can be used to increase the solubility of the active ingredient in the solvent. Sensitive substances can be added to increase storage stability.
- the system according to the invention contains a reservoir for storing the active substance solution, a liquid-conducting connection between the reservoir and the micro-spikes allowing the medicament to be conveyed from the reservoir through the capillary openings of the micro-spines to below the "stratum corneum", so that the medicament bypassing the outer layers of skin can be introduced directly into the bloodstream.
- the transport of the medication - for example in the form of an aqueous solution - can be "passive", on the one hand, due to the concentration gradient between the concentration of the active ingredient solution in the reservoir and in the blood, or "active", for example due to excess pressure stored in the reservoir, electrostatic or capillary Forces, or a pump integrated in the system.
- Active transport of the active ingredient solution is preferred - for example by means of a pump or a piezoelectric membrane.
- the volume flow (ml / time) of the drug can be adjusted or controlled by one or more additional valve (s) or a throttling section between the reservoir and the micro spikes.
- the transcorneal system according to the invention is suitable for an application period of one to several days up to 4 weeks or longer, preferably from 7 to 14 days.
- the system is so miniaturized in terms of its dimensions and weight that it can easily be fixed on the skin or in the skin over a longer period of time - similar to a plaster or a wristwatch.
- the transcomeal system can be attached using a wristband, a skin-compatible glue or the micro spikes themselves.
- the system according to the invention can be packed or sealed airtight under sterile conditions until use.
- the reservoir and micro-spikes of the system according to the invention usually form a one-part or multi-part structural unit in a housing.
- the reservoir and the micro-spike are structurally separated from one another and are connected to one another by a thin tube or a capillary. This is particularly advantageous when larger amounts of medication are to be applied over a longer period of time.
- the micro-spikes have a length of at least 10 ⁇ m, preferably 50-100 ⁇ m, particularly preferably up to 1 mm.
- the micro spikes according to the invention are conical or cylindrical, the radius of curvature of the spike tips typically being in the ⁇ m range, preferably less than 10 ⁇ m. This will damage the skin and the pain sensitivity during application was kept as low as possible.
- the micro-spikes according to the invention have capillary openings, for example in the form of bores or slots or a combination of both. Micro spikes made of a material of defined porosity - also enable the active ingredient solution to be supplied.
- micro spikes according to the invention can have, for example, capillary openings in the form of a combination of a central bore with slots to the outside.
- the transport of the active ingredient solution can be supported or regulated by mechanical, electrical, chemical and / or surface-active forces.
- a large number of micro spikes are preferably used for each transcorneal system.
- the micro-spikes are usually arranged on a surface which forms the side of the transcomeal system facing the skin. This area can be between a few square millimeters and a few square centimeters. A typical number of micro spikes is between 10 and 100, this specification should in no way limit the inventive idea.
- the active ingredient from which the micro spikes are made must be skin-friendly and biocompatible.
- glasses and metals - for example titanium - are suitable for low-cost mass production. Easily processed plastics are preferred.
- Biodegradable polymers - such as Polylactides and others have the advantage that material particles of the spines that may remain in the skin can be broken down.
- Biodegradable polymers have long been known from the prior art and have proven themselves, for example, as sutures and bone splints.
- Figure 1 shows a particularly simple embodiment of the transcomeal system (20) in an axial section.
- the system consists of a container (21) with micro spikes (23) molded onto the base (22).
- the interior of the container serves as a reservoir (24) for receiving the active ingredient solution (25).
- the active ingredient solution is present as such directly in the reservoir or is stored in a matrix, for example made of an absorbent material or a polymer.
- Containers and micro spikes have a liquid-tight outer wall (26) which is mechanically so stable that the system for activating the drug release can be placed on the skin and the micro spikes can be pressed into the skin with slight pressure.
- the active ingredient solution can get into the capillary circulation system by evading the capillary force, bypassing the transcomeal skin layer, and from there develop its systemic effect.
- a device is provided in the area of the reservoir in order to create pressure equalization - ventilation (29).
- the ventilation is usually fitted with a filter so that contaminants cannot get into the system.
- a device can be provided so that the reservoir can also be pressurized. The system is filled, for example, by injecting the active ingredient solution into the reservoir, by immersing the system in an active ingredient solution or by inserting an active ingredient-soaked matrix into the system.
- the transcomeal system is constructed in two parts, for example from a lower part which forms the micro spikes and an upper part with which the system is closed after the active substance matrix has been inserted.
- active ingredient it can be in dissolved form in an aqueous or organic physiologically compatible solvent or solvent mixture.
- suitable solvents are, for example, water, ethanol, propanol and mixtures thereof.
- the active ingredients can also be dissolved in a matrix made of a gel - for example made of a polymeric material.
- Thermoplastic materials which can be sintered from a fine-grained granulate in a mold, are primarily considered as materials for the production of the container and the micro spikes.
- a suitable choice of the parameters pressure, temperature (typically and below the melting temperature of the material) and time ensures a reproducible porosity (typically 50%).
- Subsequent targeted melting of the component surface closes it so that a porous container with a dense outer wall is created. Wall areas that are to be kept permeable, such as the vents, the spike tips, are kept below the melting temperature by cooling.
- coatings and seals can also be used, but these involve a higher outlay in terms of production technology.
- Degree of porosity and Outlet cross sections at the spike tips can be varied within certain limits and thus parameters for setting the dosing rate.
- Other suitable materials are, for example, polyethylenes, polypropylenes or polysulfones.
- the transcomeal system (30) consists of a lower housing part (31a) and an upper housing part (31b).
- the lower housing part (31a) contains micro-spikes (32) with the capillary openings (33) on the side facing the skin surface, of which only three - but enlarged - are shown in the drawing for better illustration.
- the reservoir (34) for the active ingredient solution is formed by a movable piston (37) and on the sides to the lower housing part by a bellows seal (38).
- the bellows seal can of course be replaced by other sealing measures, for example a precisely fitting guidance of the piston in the lower housing part.
- the upper part of the housing contains the micropump (39), which exerts a defined pressure on the piston and thus applies the active ingredient through the micro-spikes into the capillary circulation system.
- Micro valves (39a) can be arranged on the inside of the lower housing part in front of the capillary openings in order to prevent premature release of the drug.
- the pressure on the piston can be done pneumatically by the pump, but in another embodiment it can also be done by a miniaturized electric motor and a gear connected to it in a purely mechanical way.
- the system can include microsensors (39c), microactuators (39e), e.g. B. for active control of the microvalves (not shown), an electronic circuit (39b) with input / output option (39d) and a power supply.
- the sensors are primarily used to record and monitor control and disturbance variables, such as the concentration of active substances in the blood, the temperature or activity of the patient, and to record and monitor system variables, such as time, flow, pressure, temperature.
- the memory area of the electronic circuit can be programmed with target data and parameters by the manufacturer or by the doctor or patient via a suitable interface. The measured values of the sensors are recorded by the electronics and processed further.
- the control signals for the microactuators are derived from this in accordance with the specified control and regulating function.
- An essential component of the transcomeal system according to the invention is the configuration of the micro spikes.
- FIG. 3a shows a spike (41), which is porous at the tip and thus is continuous for the active ingredient solution.
- Figure 3b shows a spike (42) with a completely sealed outer wall.
- the tip has an extension (44), which breaks off at the root, the designed predetermined breaking point (43), when piercing and thus opens the previously dense spike tip at the breaking point.
- Another possibility of opening the spike tips is to pull off the mandrel tips which are initially sealed by a sealing film (45) when they are opened and thus "tear open” the spike tips (FIG. 3c).
- a sealing film 45
- To anchor the transcomeal system barbs can be formed on the spikes, see. Fig. 3d.
- the spines are basically made of a biologically compatible material, such as metals, ceramics and polymers, such as biodegradable polymers based on glycolide and / or lactide, possibly as copolymers with other biodegradable polymers.
- the spikes can also be made of a porous material that is permeable to the active substance, for example thermoplastic plastics, so that the active substance is released over the entire surface of the spines.
- Figure 4 shows a trough-shaped reservoir (50), in which the active ingredient solution
- the reservoir and the micro-spikes (53) penetrating the skin form a constructive unit.
- the reservoir wall (55) and the spikes (53) are, as described above, made of a porous material, the outer surface of which is sealed.
- the active ingredient solution is placed in the active ingredient matrix under slight overpressure
- FIG. 4a shows the system according to the invention in the initial state, the outwardly curved membrane (54) ensures that the drug solution is under pressure and is pressed into the drug reservoir (52). The active ingredient gets through the micro spikes
- FIG. 4b shows the membrane (54) after a large part of the active ingredient solution has been used up.
- FIG. 5 shows a section through a transcomeal system (1).
- the housing (10) contains an active substance reservoir (2) which is closed at the top by a bellows (3).
- the active substance solution (4) is located in the active substance reservoir, and reaches the pump chamber (6) on the lower side of the active substance reservoir via an inlet channel (5).
- the active substance solution reaches the micro spikes (8) arranged on the underside of the housing via an outlet channel (7) and from there through the capillary openings (9) of the micro spikes to the outside.
- the housing side parts (10a) and the housing underside (10b) together with the micro spikes form a structural unit, preferably made of a thermoplastic.
- the cover of the housing contains the energy supply in the form of a battery (11) and an electronic control (12), ventilation (13) enables the bellows to adapt to this reduced volume when the active substance solution is dispensed through the micro spikes.
- the active ingredient solution is conveyed through a piezoelectric membrane (14) which carries out an electrically controlled pump movement.
- the inlet channel (5) is designed in such a way that the active substance solution is pumped through the piezoelectric membrane (14) to the outlets of the micro spikes. This takes place either through a valve or because the cross section of the inlet channel is smaller than that of the outlet channel (7).
- the micro spikes are protected by a spike protection (15), for example in the form of a cap.
- Figure 6 shows some embodiments of the micro-spike according to the invention in a section and a plan view.
- Figure 6a shows a micro-spike with a central opening (9) and cylindrical outer shape (8) and a conical tip (10).
- Figure 6b shows a micro-spike with an opening in the form of a slot (9) and cylindrical outer shape (8).
- FIG. 6c shows a micro spike with flattened outer sides (8), the opening being arranged in the form of a slot.
- Figure 6d shows a micro-spike with a cylindrical outer shape and angled tip (10).
- FIG. 6e shows an embodiment of the micro-cutting edges according to the invention, which can be used instead of the micro-spikes in a section and a top view.
- the openings (9) for the active substance solution are usually located close to the cutting edge (8a) on the underside (10b) of the reservoir (see FIG. 5), so that the active substance solution can pass through the scratched skin surface from there and develop its systemic effect.
- FIG. 6f shows an embodiment of a micro-cutting edge in the form of a grain with pointed edges (8b) which scratch the skin.
- the opening (s) (9) are in the vicinity of the grain.
- micro cutting edges have approximately the same order of magnitude as the micro spikes already described.
- micro spikes or micro cutting edges are typically arranged on the underside of the transcomeal system and form a structural unit; their number is, for example, between 10 and 100.
- the dosage of the drug can be controlled via the volume flows, which in turn depends on the sum of the cross sections of the openings of the micro spikes.
Abstract
Description
Claims
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002226718A CA2226718C (en) | 1995-07-14 | 1996-07-15 | Transcorneal drug-release system |
EP96926348A EP0840634B1 (de) | 1995-07-14 | 1996-07-15 | Transcorneales arzneimittelfreigabesystem |
HU9802773A HU222342B1 (hu) | 1995-07-14 | 1996-07-15 | Transzkorneális hatóanyag-leadó rendszer |
AU66567/96A AU722943B2 (en) | 1995-07-14 | 1996-07-15 | Transcorneal drug-release system |
PL96324530A PL181658B1 (pl) | 1995-07-14 | 1996-07-15 | Urzadzenia do kontrolowanego uwalniania lekarstwa poprzez warstwe zrogowaciala PL PL PL |
NZ313984A NZ313984A (en) | 1995-07-14 | 1996-07-15 | Transcorneal drug-release system with multiple microblades and pump |
US08/983,197 US6132755A (en) | 1995-07-14 | 1996-07-15 | Transcorneal drug-release system |
BR9609796A BR9609796A (pt) | 1995-07-14 | 1996-07-15 | Sistema transcórneo de liberação de droga |
EE9800025A EE04006B1 (et) | 1995-07-14 | 1996-07-15 | Transkorneaalne seade ravimite kontrollitavaks manustamiseks |
UA98020771A UA62918C2 (en) | 1995-07-14 | 1996-07-15 | Transcorneal drug-release system |
SI9630389T SI0840634T1 (en) | 1995-07-14 | 1996-07-15 | Transcorneal drug-release system |
SK49-98A SK284358B6 (sk) | 1995-07-14 | 1996-07-15 | Transkorneálny systém na kontrolované uvoľňovanie liečiva |
DE59608081T DE59608081D1 (de) | 1995-07-14 | 1996-07-15 | Transcorneales arzneimittelfreigabesystem |
RO98-00032A RO118738B1 (ro) | 1995-07-14 | 1996-07-15 | Sistem de penetrare a stratului cornos al pielii, pentru eliberarea medicamentelor |
JP9506273A JPH11509123A (ja) | 1995-07-14 | 1996-07-15 | 経角質薬物放出システム |
IL12290796A IL122907A0 (en) | 1995-07-14 | 1996-07-15 | Transcorneal drug-release system |
MX9800401A MX9800401A (es) | 1995-07-14 | 1996-07-15 | Sistema transcorneal de liberacion de medicamentos. |
AT96926348T ATE207769T1 (de) | 1995-07-14 | 1996-07-15 | Transcorneales arzneimittelfreigabesystem |
DK96926348T DK0840634T3 (da) | 1995-07-14 | 1996-07-15 | Transcornealt lægemiddelfrigivelsessystem |
NO19980147A NO316313B1 (no) | 1995-07-14 | 1998-01-13 | Transkornealt system for kontrollert frigj degree ring av legemidler |
BG102200A BG63142B1 (bg) | 1995-07-14 | 1998-01-20 | Транскорнеална система за освобождаване на лекарствено средство |
HK98111847A HK1010844A1 (en) | 1995-07-14 | 1998-11-09 | Transcorneal drug-release system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19525607.7 | 1995-07-14 | ||
DE19525607A DE19525607A1 (de) | 1995-07-14 | 1995-07-14 | Transcorneales Arzneimittelfreigabesystem |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997003718A1 true WO1997003718A1 (de) | 1997-02-06 |
Family
ID=7766771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/003090 WO1997003718A1 (de) | 1995-07-14 | 1996-07-15 | Transcorneales arzneimittelfreigabesystem |
Country Status (34)
Country | Link |
---|---|
US (1) | US6132755A (de) |
EP (1) | EP0840634B1 (de) |
JP (1) | JPH11509123A (de) |
KR (1) | KR100430703B1 (de) |
CN (1) | CN1183979C (de) |
AR (1) | AR004499A1 (de) |
AT (1) | ATE207769T1 (de) |
AU (1) | AU722943B2 (de) |
BG (1) | BG63142B1 (de) |
BR (1) | BR9609796A (de) |
CA (1) | CA2226718C (de) |
CO (1) | CO4700491A1 (de) |
CZ (1) | CZ290458B6 (de) |
DE (2) | DE19525607A1 (de) |
DK (1) | DK0840634T3 (de) |
EE (1) | EE04006B1 (de) |
ES (1) | ES2163035T3 (de) |
HK (1) | HK1010844A1 (de) |
HU (1) | HU222342B1 (de) |
IL (1) | IL122907A0 (de) |
MX (1) | MX9800401A (de) |
NO (1) | NO316313B1 (de) |
NZ (1) | NZ313984A (de) |
PL (1) | PL181658B1 (de) |
PT (1) | PT840634E (de) |
RO (1) | RO118738B1 (de) |
RU (1) | RU2209640C2 (de) |
SK (1) | SK284358B6 (de) |
TR (1) | TR199800048T1 (de) |
TW (1) | TW375528B (de) |
UA (1) | UA62918C2 (de) |
UY (1) | UY24277A1 (de) |
WO (1) | WO1997003718A1 (de) |
ZA (1) | ZA965931B (de) |
Cited By (61)
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WO2000074765A1 (en) * | 1999-06-09 | 2000-12-14 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
WO2000074766A1 (en) * | 1999-06-09 | 2000-12-14 | The Procter & Gamble Company | Intracutaneous edged microneedle structure |
EP1086719A1 (de) * | 1999-09-24 | 2001-03-28 | Becton Dickinson and Company | Methode und Vorrichtung zum Abscheuern der Haut |
WO2001041864A1 (en) | 1999-12-10 | 2001-06-14 | Alza Corporation | Skin treatment apparatus for sustained transdermal drug delivery |
EP1113832A1 (de) * | 1998-09-18 | 2001-07-11 | University of Utah Research Foundation | Mikronadel mit mikromechanisch bearbeiteter oberfläche |
WO2001052731A1 (en) * | 2000-01-21 | 2001-07-26 | Instrumentarium Corporation | Medical electrode |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
WO2002005889A1 (en) * | 2000-07-17 | 2002-01-24 | Becton, Dickinson And Company | Delivery device with microneedles for the transdermal administration of a substance |
WO2002007813A1 (en) * | 2000-07-21 | 2002-01-31 | Smithkline Beecham Biologicals S.A. | Vaccines |
WO2002032331A2 (en) * | 2000-10-16 | 2002-04-25 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
WO2002002180A3 (en) * | 2000-06-29 | 2002-05-02 | Becton Dickinson Co | Method and apparatus for transdermally sampling or administering a substance to a patient |
JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
JP2002521222A (ja) * | 1998-07-22 | 2002-07-16 | イギリス国 | ダクトを有するシリコンの微細加工突起 |
WO2002030506A3 (en) * | 2000-10-12 | 2002-08-15 | Ink Jet Tech Ltd | Transdermal method |
SG92728A1 (en) * | 1999-09-22 | 2002-11-19 | Becton Dickinson Co | Method and apparatus for the transdermal administration of a substrate |
US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
WO2003080174A1 (fr) * | 2002-03-26 | 2003-10-02 | Juridical Foundation Osaka Industrial Promotion Organization | Systeme de traitement medical et procede de production destine a ce systeme |
US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
WO2005004842A2 (en) | 2003-06-30 | 2005-01-20 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
US6855372B2 (en) | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
US6855131B2 (en) | 2000-10-13 | 2005-02-15 | Alza Corporation | Microprotrusion member retainer for impact applicator |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
WO2005042054A2 (en) | 2003-10-24 | 2005-05-12 | Alza Corporation | Pretreatment method and system for enhancing transdermal drug delivery |
US6908453B2 (en) | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
US7047070B2 (en) | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
US7048723B1 (en) * | 1998-09-18 | 2006-05-23 | The University Of Utah Research Foundation | Surface micromachined microneedles |
EP1669100A1 (de) * | 2004-12-13 | 2006-06-14 | Debiotech S.A. | Micro-aiguilles |
US7087035B2 (en) | 1999-12-10 | 2006-08-08 | Alza Corporation | Device and method for enhancing skin piercing by microprotrusions |
US7097631B2 (en) | 2003-10-31 | 2006-08-29 | Alza Corporation | Self-actuating applicator for microprojection array |
US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US7131960B2 (en) | 2000-10-13 | 2006-11-07 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
CN100402107C (zh) * | 2004-03-31 | 2008-07-16 | 中国科学院理化技术研究所 | 金属微针阵列芯片及其制备方法和用途 |
US7419481B2 (en) | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US7438926B2 (en) | 2000-09-08 | 2008-10-21 | Alza Corporation | Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure |
US7455654B2 (en) | 2003-10-28 | 2008-11-25 | Alza Corporation | Method and apparatus for reducing the incidence of tobacco use |
US7537795B2 (en) | 2000-10-26 | 2009-05-26 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
JP2009119296A (ja) * | 1998-06-10 | 2009-06-04 | Georgia Tech Research Corp | 微小針デバイスおよび製造方法ならびにそれらの使用 |
US7569032B2 (en) | 2000-11-28 | 2009-08-04 | Boston Scientific Scimed, Inc. | Medical device for delivery of a biologically active material to a lumen |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
CN101905856A (zh) * | 2010-06-11 | 2010-12-08 | 北京大学 | 一种用于透皮给药的平面空心微针的制备方法 |
US7858112B2 (en) | 2002-02-28 | 2010-12-28 | Lintec Corporation | Percutaneous absorption system and percutaneous absorption method |
US7963935B2 (en) | 2001-04-20 | 2011-06-21 | Alza Corporation | Microprojection array having a beneficial agent containing coating |
US8900194B2 (en) | 2002-07-19 | 2014-12-02 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
WO2015017561A1 (en) | 2013-07-30 | 2015-02-05 | Zosano Pharma, Inc. | Low-profile microneedle patch applicator |
US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US9192749B2 (en) | 2000-10-13 | 2015-11-24 | Alza Corporation | Microblade array impact applicator |
EP2974758A1 (de) * | 2014-07-15 | 2016-01-20 | LTS LOHMANN Therapie-Systeme AG | Zylinder-Kolben-Einheit mit Kanülen |
US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
EP3251722A1 (de) | 2001-04-20 | 2017-12-06 | ALZA Corporation | Mikroprojektionsanordnung mit einer beschichtung, der ein vorteilhaftes mittel enthält und beschichtungsverfahren dafuer |
US9962534B2 (en) | 2013-03-15 | 2018-05-08 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
US10245422B2 (en) | 2013-03-12 | 2019-04-02 | Corium International, Inc. | Microprojection applicators and methods of use |
US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US11052231B2 (en) | 2012-12-21 | 2021-07-06 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
Families Citing this family (226)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE234129T1 (de) * | 1996-06-18 | 2003-03-15 | Alza Corp | Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten |
US6746688B1 (en) * | 1996-10-13 | 2004-06-08 | Neuroderm Ltd. | Apparatus for the transdermal treatment of Parkinson's disease |
WO1998028037A1 (en) * | 1996-12-20 | 1998-07-02 | Alza Corporation | Device and method for enhancing transdermal agent flux |
JP3879785B2 (ja) * | 1997-05-20 | 2007-02-14 | 日東電工株式会社 | キラーt細胞賦活剤 |
US6918901B1 (en) | 1997-12-10 | 2005-07-19 | Felix Theeuwes | Device and method for enhancing transdermal agent flux |
DK1037686T3 (da) * | 1997-12-11 | 2006-01-02 | Alza Corp | Apparat til forögelse af transdermal gennemströmning af midler |
PT1037687E (pt) * | 1997-12-11 | 2008-12-17 | Alza Corp | Dispositivo para melhoramento de fluxo transdérmico de agente |
US7344499B1 (en) | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
GB9815819D0 (en) * | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
US6532386B2 (en) | 1998-08-31 | 2003-03-11 | Johnson & Johnson Consumer Companies, Inc. | Electrotransort device comprising blades |
CA2352974A1 (en) * | 1998-12-18 | 2000-06-22 | John H. Livingston | Insertion sets with micro-piercing members for use with medical devices and methods of using the same |
EP1171195B1 (de) | 1999-04-16 | 2005-03-16 | Johnson & Johnson Consumer Companies, Inc. | Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
DE60044084D1 (de) * | 1999-06-04 | 2010-05-12 | Georgia Tech Res Inst | Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
AU6076200A (en) | 1999-07-08 | 2001-01-30 | Johnson & Johnson Consumer Companies, Inc. | Exothermic bandage |
US6890553B1 (en) | 1999-07-08 | 2005-05-10 | Johnson & Johnson Consumer Companies, Inc. | Exothermic topical delivery device |
US7133717B2 (en) | 1999-08-25 | 2006-11-07 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery and diagnostic sampling |
US7113821B1 (en) | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
US6622035B1 (en) | 2000-01-21 | 2003-09-16 | Instrumentarium Corp. | Electrode for measurement of weak bioelectrical signals |
WO2001066065A2 (en) * | 2000-03-09 | 2001-09-13 | Nanopass Ltd. | Systems and methods for fluid transport through dermal barriers |
IL134997A0 (en) * | 2000-03-09 | 2001-05-20 | Yehoshua Yeshurun | Health care system based on micro device |
US7404815B2 (en) | 2000-05-01 | 2008-07-29 | Lifescan, Inc. | Tissue ablation by shear force for sampling biological fluids and delivering active agents |
US6659982B2 (en) * | 2000-05-08 | 2003-12-09 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
US6629949B1 (en) | 2000-05-08 | 2003-10-07 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
US6533949B1 (en) * | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
JP2002085561A (ja) * | 2000-09-14 | 2002-03-26 | Terumo Corp | 液体注入針 |
US7131987B2 (en) * | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
WO2002050584A2 (en) | 2000-12-21 | 2002-06-27 | Biovalve Technologies, Inc. | Microneedle array systems |
DE10065168A1 (de) * | 2000-12-23 | 2002-07-11 | Lohmann Therapie Syst Lts | Nadelpflaster mit vermindertem Infektionsrisiko |
DE60213976T2 (de) * | 2001-06-08 | 2007-04-26 | Becton Dickinson And Co. | Vorrichtung zur manipulation von nadeln oder polierarray |
SE0102736D0 (sv) * | 2001-08-14 | 2001-08-14 | Patrick Griss | Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles |
WO2003024507A2 (en) | 2001-09-19 | 2003-03-27 | Biovalve Technologies, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
US8920375B2 (en) * | 2001-09-21 | 2014-12-30 | Valeritas, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
US6830562B2 (en) | 2001-09-27 | 2004-12-14 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
AU2002337788A1 (en) * | 2001-09-28 | 2003-04-07 | Biovalve Technologies, Inc. | Microneedle with membrane |
CA2500452A1 (en) * | 2001-09-28 | 2003-04-03 | Biovalve Technologies, Inc. | Switchable microneedle arrays and systems and methods relating to same |
US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
US20030093040A1 (en) * | 2001-10-29 | 2003-05-15 | Mikszta John A. | Method and device for the delivery of a substance |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
JP4608187B2 (ja) * | 2002-02-28 | 2011-01-05 | リンテック株式会社 | 経皮吸収型製剤 |
JP2005518873A (ja) * | 2002-03-04 | 2005-06-30 | ナノ パス テクノロジーズ リミテッド | 生体障壁を横切る流体輸送の為の装置及び方法 |
BR0308694A (pt) | 2002-03-26 | 2007-01-09 | Becton Dickinson Co | dispositivo e método de entrega de fluido com múltiplos estágios |
US6945952B2 (en) * | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
DK1534376T3 (en) * | 2002-06-25 | 2016-12-05 | Theraject Inc | QUICK-SOLVING MICROPERFORATORS FOR PHARMACEUTICAL DELIVERY AND OTHER APPLICATIONS |
US6899838B2 (en) * | 2002-07-12 | 2005-05-31 | Becton, Dickinson And Company | Method of forming a mold and molding a micro-device |
US7250037B2 (en) * | 2002-07-22 | 2007-07-31 | Becton, Dickinson And Company | Patch-like infusion device |
US20040051019A1 (en) | 2002-09-02 | 2004-03-18 | Mogensen Lasse Wesseltoft | Apparatus for and a method of adjusting the length of an infusion tube |
AU2003275311A1 (en) * | 2002-09-16 | 2004-04-30 | Sung-Yun Kwon | Solid micro-perforators and methods of use |
DE10243917A1 (de) * | 2002-09-20 | 2004-04-01 | Udo Dr. Auweiler | Vorrichtung zur subkutanen Abgabe eines pharmazeutischen Wirkstoffes |
US20040106904A1 (en) * | 2002-10-07 | 2004-06-03 | Gonnelli Robert R. | Microneedle array patch |
IL152575A (en) * | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
IL152573A (en) * | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
IL152912A0 (en) * | 2002-11-18 | 2003-06-24 | Nanopass Ltd | Micro needle systems |
DK200201823A (da) | 2002-11-26 | 2004-05-27 | Maersk Medical As | Forbindelsesstykke for en slangeforbindelse |
EP1426662A1 (de) * | 2002-12-06 | 2004-06-09 | Boehringer Ingelheim International GmbH | Kolbenpumpsystem |
US7578954B2 (en) | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
DE602004028231D1 (de) * | 2003-05-08 | 2010-09-02 | Novo Nordisk As | Eine auf die haut aufbringbare injektionsvorrichtung mit abtrennbarem betätigungsteil zum einführen der nadel |
ATE392223T1 (de) | 2003-05-08 | 2008-05-15 | Novo Nordisk As | Interne nadeleinführvorrichtung |
EP1475113A1 (de) * | 2003-05-08 | 2004-11-10 | Novo Nordisk A/S | Externer Nadeleinsetzer |
EP1502613A1 (de) | 2003-08-01 | 2005-02-02 | Novo Nordisk A/S | Gerät mit Rückziehvorrichting für eine Nadel |
EP2609948B1 (de) * | 2003-08-12 | 2020-01-08 | Becton, Dickinson and Company | Pflasterähnliche Infusionsvorrichtung |
WO2005020912A2 (en) | 2003-08-25 | 2005-03-10 | 3M Innovative Properties Company | Delivery of immune response modifier compounds |
WO2005060621A2 (en) * | 2003-11-21 | 2005-07-07 | The Regents Of The University Of California | Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles |
US8017145B2 (en) * | 2003-12-22 | 2011-09-13 | Conopco, Inc. | Exfoliating personal care wipe article containing an array of projections |
CA2552385C (en) * | 2003-12-29 | 2013-07-23 | 3M Innovative Properties Company | Medical devices and kits including same |
US8551391B2 (en) * | 2004-02-17 | 2013-10-08 | Avery Dennison Corporation | Method of making microneedles |
JP2007523771A (ja) * | 2004-02-23 | 2007-08-23 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの成形方法 |
US7591618B2 (en) | 2004-02-25 | 2009-09-22 | Agency For Science, Technology And Research | Machining method for micro abraders and micro abraders produced thereby |
JP2005246595A (ja) * | 2004-03-05 | 2005-09-15 | Ritsumeikan | マイクロニードルアレイ及びその製造方法 |
CA2560840C (en) | 2004-03-24 | 2014-05-06 | Corium International, Inc. | Transdermal delivery device |
DK1727576T3 (da) | 2004-03-26 | 2009-07-06 | Unomedical As | Infusionssæt |
WO2005094920A1 (en) | 2004-03-30 | 2005-10-13 | Novo Nordisk A/S | Actuator system comprising lever mechanism |
WO2005123173A1 (en) * | 2004-06-10 | 2005-12-29 | 3M Innovative Properties Company | Patch application device and kit |
US8062250B2 (en) | 2004-08-10 | 2011-11-22 | Unomedical A/S | Cannula device |
ITPD20040252A1 (it) * | 2004-10-14 | 2005-01-14 | Bidoia Sas Di Gianfranco Bidoi | Irrigatore chirurgico |
ATE504328T1 (de) | 2004-11-18 | 2011-04-15 | 3M Innovative Properties Co | Mikronadelanordungsapplikator und halter |
WO2006055799A1 (en) * | 2004-11-18 | 2006-05-26 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
KR20070102669A (ko) | 2004-11-18 | 2007-10-19 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 로우-프로파일 미세 바늘 어레이 인가 장치 |
JP5015787B2 (ja) | 2004-11-18 | 2012-08-29 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイの接触コーティング法 |
US20080009801A1 (en) * | 2004-12-02 | 2008-01-10 | Nickel Janice H | Method for dispensing material into a drug delivery device |
AU2005314151B2 (en) | 2004-12-07 | 2011-09-08 | 3M Innovative Properties Company | Method of molding a microneedle |
AU2005313662B2 (en) | 2004-12-10 | 2011-07-14 | Unomedical A/S | Cannula inserter |
CN101107028B (zh) | 2005-01-24 | 2013-04-10 | 诺和诺德公司 | 经皮设备组件 |
KR100679714B1 (ko) * | 2005-02-07 | 2007-02-07 | 재단법인서울대학교산학협력재단 | 3차원 구조의 마이크로 스파이크 및 그 제조 방법 |
US7985199B2 (en) | 2005-03-17 | 2011-07-26 | Unomedical A/S | Gateway system |
JP4793806B2 (ja) * | 2005-03-22 | 2011-10-12 | Tti・エルビュー株式会社 | イオントフォレーシス装置 |
WO2006101146A1 (ja) * | 2005-03-22 | 2006-09-28 | Transcutaneous Technologies Inc. | イオントフォレーシス装置 |
WO2006102507A1 (en) * | 2005-03-23 | 2006-09-28 | Velcro Industries B.V. | Molding touch fastener elements |
WO2006105146A2 (en) | 2005-03-29 | 2006-10-05 | Arkal Medical, Inc. | Devices, systems, methods and tools for continuous glucose monitoring |
US7601284B2 (en) * | 2005-04-06 | 2009-10-13 | Velcro Industries B.V. | Molding fastener elements on folded substrate |
JP5301985B2 (ja) | 2005-04-07 | 2013-09-25 | スリーエム イノベイティブ プロパティズ カンパニー | ツールフィードバック感知のためのシステム及び方法 |
US20060253078A1 (en) * | 2005-04-25 | 2006-11-09 | Wu Jeffrey M | Method of treating skin disorders with stratum corneum piercing device |
US20070270738A1 (en) * | 2005-04-25 | 2007-11-22 | Wu Jeffrey M | Method of treating ACNE with stratum corneum piercing patch |
US20080009802A1 (en) * | 2005-04-25 | 2008-01-10 | Danilo Lambino | Method of treating acne with stratum corneum piercing device |
US20060283465A1 (en) * | 2005-06-16 | 2006-12-21 | Nickel Janice H | Smart drug delivery system and a method of implementation thereof |
EP1904158B1 (de) | 2005-06-24 | 2013-07-24 | 3M Innovative Properties Company | Faltbares Pflaster mit Mikronadelnanordnung |
AU2006261899B2 (en) | 2005-06-27 | 2012-05-10 | Kindeva Drug Delivery L.P. | Microneedle cartridge assembly and method of applying |
CA2613111C (en) * | 2005-06-27 | 2015-05-26 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
US8118753B2 (en) * | 2005-08-18 | 2012-02-21 | Seoul National University Industry Foundation | Barb-wired micro needle made of single crystalline silicon and biopsy method and medicine injecting method using the same |
US20070060837A1 (en) * | 2005-08-18 | 2007-03-15 | Seoul National University Industry Foundation | Barb-wired micro needle made of single crystalline silicon and biopsy method and medicine injecting method using the same |
DE102005040251A1 (de) * | 2005-08-24 | 2007-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Transcorneales System zur Abgabe eines Arzneimittel-Wirkstoffes |
US20090035446A1 (en) * | 2005-09-06 | 2009-02-05 | Theraject, Inc. | Solid Solution Perforator Containing Drug Particle and/or Drug-Adsorbed Particles |
US8518069B2 (en) | 2005-09-07 | 2013-08-27 | Cabochon Aesthetics, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9486274B2 (en) | 2005-09-07 | 2016-11-08 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9358033B2 (en) * | 2005-09-07 | 2016-06-07 | Ulthera, Inc. | Fluid-jet dissection system and method for reducing the appearance of cellulite |
US9011473B2 (en) | 2005-09-07 | 2015-04-21 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US10548659B2 (en) | 2006-01-17 | 2020-02-04 | Ulthera, Inc. | High pressure pre-burst for improved fluid delivery |
PL1762259T3 (pl) | 2005-09-12 | 2011-03-31 | Unomedical As | Urządzenie wprowadzające, przeznaczone do zestawu infuzyjnego, z pierwszą i drugą jednostką sprężynową |
JP2009509659A (ja) * | 2005-09-30 | 2009-03-12 | Tti・エルビュー株式会社 | 生体界面への活性物質の送達のイオントフォレーシス装置及び方法 |
US20080262416A1 (en) * | 2005-11-18 | 2008-10-23 | Duan Daniel C | Microneedle Arrays and Methods of Preparing Same |
WO2007061964A1 (en) * | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Methods for coating microneedles |
US9248317B2 (en) | 2005-12-02 | 2016-02-02 | Ulthera, Inc. | Devices and methods for selectively lysing cells |
US7885793B2 (en) | 2007-05-22 | 2011-02-08 | International Business Machines Corporation | Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution |
USD655807S1 (en) | 2005-12-09 | 2012-03-13 | Unomedical A/S | Medical device |
WO2007075614A1 (en) * | 2005-12-21 | 2007-07-05 | 3M Innovative Properties Company | Microneedle devices |
PL2077128T3 (pl) | 2005-12-23 | 2011-10-31 | Unomedical As | Urządzenie wstrzykujące |
US20070191811A1 (en) * | 2006-02-10 | 2007-08-16 | Joseph Berglund | System and Method for Treating a Vascular Condition |
EP1988958B2 (de) | 2006-02-28 | 2016-03-16 | Unomedical A/S | Einführungssystem für ein infusionsteil und infusionsteil mit nadelschutz |
CN101400320A (zh) * | 2006-03-10 | 2009-04-01 | 阿尔扎公司 | 采用高防渗定位器的微突起阵列应用 |
WO2007104755A1 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Secure pairing of electronic devices using dual means of communication |
US9119945B2 (en) | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
WO2007141210A1 (en) | 2006-06-06 | 2007-12-13 | Novo Nordisk A/S | Assembly comprising skin-mountable device and packaging therefore |
MX2008015245A (es) | 2006-06-07 | 2008-12-15 | Unomedical As | Insertador. |
RU2438720C2 (ru) | 2006-06-09 | 2012-01-10 | Уномедикал А/С | Установочная подкладка |
RU2443436C2 (ru) | 2006-08-02 | 2012-02-27 | Уномедикал А/С | Канюльное и доставочное устройство |
US20080058726A1 (en) * | 2006-08-30 | 2008-03-06 | Arvind Jina | Methods and Apparatus Incorporating a Surface Penetration Device |
EP2077882A2 (de) * | 2006-10-25 | 2009-07-15 | Nektar Therapeutics | Pulverdispersionsvorrichtung, verfahren zur herstellung und verwendung dieser vorrichtung und komponenten zur verwendung mit dieser vorrichtung oder anderen geräten |
EP1917990A1 (de) | 2006-10-31 | 2008-05-07 | Unomedical A/S | Infusionsset |
CA2676221C (en) | 2007-01-22 | 2016-12-20 | Corium International, Inc. | Applicators for microneedles |
FR2912919B1 (fr) * | 2007-02-22 | 2009-05-01 | Bernard Perriere | Dispositif d'injection miniaturise a usage medical |
US8439861B2 (en) | 2007-04-24 | 2013-05-14 | Velcro Industries B.V. | Skin penetrating touch fasteners |
US9186480B2 (en) | 2007-06-20 | 2015-11-17 | Unomedical A/S | Apparatus for making a catheter |
RU2010103450A (ru) | 2007-07-03 | 2011-08-10 | Уномедикал А/С (Dk) | Устройство введения с бистабильными равновесными состояниями |
KR20100062991A (ko) | 2007-07-10 | 2010-06-10 | 우노메디컬 에이/에스 | 두 개의 스프링을 갖는 인서터 |
WO2009010396A1 (en) | 2007-07-18 | 2009-01-22 | Unomedical A/S | Insertion device with pivoting action |
KR20090015449A (ko) * | 2007-08-08 | 2009-02-12 | 현대자동차주식회사 | 수크로스 탄소 전구체로부터 결정성이 우수한 기공성그래파이트 탄소의 제조방법 |
US8439940B2 (en) | 2010-12-22 | 2013-05-14 | Cabochon Aesthetics, Inc. | Dissection handpiece with aspiration means for reducing the appearance of cellulite |
WO2009056616A1 (en) | 2007-10-31 | 2009-05-07 | Novo Nordisk A/S | Non-porous material as sterilization barrier |
CN101951978A (zh) | 2008-02-13 | 2011-01-19 | 优诺医疗有限公司 | 套管部件和流体路径之间的密封件 |
US9566384B2 (en) | 2008-02-20 | 2017-02-14 | Unomedical A/S | Insertion device with horizontally moving part |
EP2100850A1 (de) | 2008-03-11 | 2009-09-16 | Stichting Voor De Technische Wetenschappen | Mikronadelarray und Verfahren zur Mikronadelherstellung |
JP5584202B2 (ja) * | 2008-05-21 | 2014-09-03 | セラジェクト, インコーポレイテッド | 固溶体穿孔器パッチの製造方法及びその使用 |
CN102256657A (zh) | 2008-12-22 | 2011-11-23 | 犹诺医药有限公司 | 包括粘合垫的医疗器械 |
JP5653942B2 (ja) | 2009-02-26 | 2015-01-14 | ザ ユニバーシティ オブ ノース キャロライナ アット チャペル ヒル | 介入薬剤送達システム |
US20110006458A1 (en) * | 2009-04-24 | 2011-01-13 | Corium International, Inc. | Methods for manufacturing microprojection arrays |
EP2275164A1 (de) | 2009-07-15 | 2011-01-19 | Debiotech S.A. | Mikronadeln mit mehreren Kanälen |
WO2011012465A1 (en) | 2009-07-30 | 2011-02-03 | Unomedical A/S | Inserter device with horizontal moving part |
AU2010276511B2 (en) | 2009-07-31 | 2013-09-19 | Kindeva Drug Delivery L.P. | Hollow microneedle arrays |
US9358064B2 (en) | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
US11096708B2 (en) | 2009-08-07 | 2021-08-24 | Ulthera, Inc. | Devices and methods for performing subcutaneous surgery |
EP2461853B1 (de) | 2009-08-07 | 2016-03-30 | Unomedical A/S | Verabreichungsrvorrichtung mit Sensor und einer oder mehreren Kanülen |
US8062568B2 (en) * | 2009-08-27 | 2011-11-22 | Korea University Research And Business Foundation | Nano pattern writer |
HU227748B1 (en) | 2009-09-21 | 2012-02-28 | Zoltan Dr Piros | Microinfusion device for dosing insuline in the treatment of diabetes |
US20110144591A1 (en) * | 2009-12-11 | 2011-06-16 | Ross Russell F | Transdermal Delivery Device |
ES2617145T3 (es) | 2009-12-16 | 2017-06-15 | Becton, Dickinson And Company | Dispositivo de inyección automática |
US9833562B2 (en) | 2009-12-16 | 2017-12-05 | Becton, Dickinson And Company | Self-injection device |
EP2512559B1 (de) | 2009-12-16 | 2018-12-05 | Becton, Dickinson and Company | Selbstinjektionsvorrichtung |
CN102753212B (zh) | 2009-12-16 | 2016-04-27 | 贝克顿·迪金森公司 | 自注射装置 |
DK2512551T3 (da) | 2009-12-16 | 2019-07-01 | Becton Dickinson Co | Selvinjektionsapparat |
CN102753225B (zh) | 2009-12-16 | 2014-10-08 | 贝克顿·迪金森公司 | 自注射装置 |
MX2012011085A (es) | 2010-03-30 | 2012-10-10 | Unomedical As | Dispositivo medico. |
DK2563450T3 (da) | 2010-04-28 | 2017-11-13 | Kimberly Clark Co | Apparat til administration af rheumatoid-arthritis-medikament |
EP2563451B1 (de) | 2010-04-28 | 2017-11-01 | Kimberly-Clark Worldwide, Inc. | Medizinische vorrichtungen zur abgabe von sirna |
MX2012012567A (es) | 2010-04-28 | 2012-11-21 | Kimberly Clark Co | Metodo para aumentar la permeabilidad de una barrera epitelial. |
US9526883B2 (en) | 2010-04-28 | 2016-12-27 | Kimberly-Clark Worldwide, Inc. | Composite microneedle array including nanostructures thereon |
WO2011156095A2 (en) | 2010-06-10 | 2011-12-15 | The Regents Of The University Of California | Textile-based printable electrodes for electrochemical sensing |
DE102010038733A1 (de) * | 2010-07-30 | 2012-02-02 | Robert Bosch Gmbh | Modulare Mikronadel-Transportvorrichtung |
JP5718622B2 (ja) * | 2010-08-31 | 2015-05-13 | Asti株式会社 | マイクロニードルアレイ装置 |
US8945071B2 (en) | 2010-09-02 | 2015-02-03 | Becton, Dickinson And Company | Self-injection device having needle cover with activation preventer |
EP2618873B1 (de) * | 2010-09-21 | 2020-03-11 | Israel Shamir Lebovitz | Spekulum mit mehreren ausfahrbaren multi-direktionalen injektionsnadeln |
EP2433663A1 (de) | 2010-09-27 | 2012-03-28 | Unomedical A/S | Einführsystem |
EP2436412A1 (de) | 2010-10-04 | 2012-04-04 | Unomedical A/S | Sprinklerkanüle |
US10441767B2 (en) | 2010-10-27 | 2019-10-15 | Asti Corporation | Jig for microneedle array placement and microneedle array device |
CN102641549B (zh) * | 2011-02-18 | 2016-05-04 | 帕洛阿尔托研究中心公司 | 包括微针的透粘膜药物输送装置和方法 |
US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
KR101241059B1 (ko) * | 2011-03-04 | 2013-03-11 | 연세대학교 산학협력단 | 마이크로 니들을 이용한 혈관외벽 장착 약물 전달장치 및 약물 전달방법 |
US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
EP2739333A1 (de) * | 2011-08-05 | 2014-06-11 | Unitract Syringe Pty Ltd | Kanüle mit kontrollierter einführtiefe |
KR101542549B1 (ko) | 2011-09-02 | 2015-08-06 | 산디아 코포레이션 | 바이오센싱 및 약물 전달을 위한 마이크로니들 어레이 |
CN103957962B (zh) | 2011-10-05 | 2017-07-07 | 犹诺医药有限公司 | 用于同时插入多个经皮部分的插入物 |
EP2583715A1 (de) | 2011-10-19 | 2013-04-24 | Unomedical A/S | Infusionsschlauchsystem und Herstellungsverfahren |
JP6100271B2 (ja) | 2011-10-27 | 2017-03-22 | キンバリー クラーク ワールドワイド インコーポレイテッド | 高粘性生理活性薬剤の経皮的送達 |
DK3542851T3 (da) | 2011-10-27 | 2022-03-14 | Sorrento Therapeutics Inc | Implanterbare indretninger til levering af bioaktive midler |
US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
US9440051B2 (en) | 2011-10-27 | 2016-09-13 | Unomedical A/S | Inserter for a multiplicity of subcutaneous parts |
JP5845808B2 (ja) * | 2011-10-28 | 2016-01-20 | 凸版印刷株式会社 | マイクロニードルデバイスおよびその製造方法 |
JP5788019B2 (ja) * | 2011-11-18 | 2015-09-30 | 南部化成株式会社 | 経皮投薬装置 |
US10646702B2 (en) | 2013-01-21 | 2020-05-12 | Paean Aesthetics Inc. | Microneedle, mould for producing same, and production method for same |
CN103157178B (zh) * | 2013-02-05 | 2014-12-31 | 北京化工大学 | 精确控制微针插入长度的印章式工具 |
US9987427B1 (en) | 2014-06-24 | 2018-06-05 | National Technology & Engineering Solutions Of Sandia, Llc | Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof |
JP5967595B2 (ja) * | 2014-09-08 | 2016-08-10 | 株式会社かいわ | 穿刺器具 |
NL2013654B1 (nl) * | 2014-10-20 | 2016-08-11 | Helène Tamara Witteman Amber | Draagbare injectie-inrichting voor draagbare bevestiging aan een lichaamsdeel, voor het in een draagtoestand injecteren van een geneesmiddel via de huid van het lichaamsdeel. |
JP6906885B2 (ja) | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
CN104307098B (zh) * | 2014-11-15 | 2016-09-07 | 唐晨 | 微针给药装置及其制造方法 |
JP6622818B2 (ja) * | 2014-12-16 | 2019-12-18 | チュビック インコーポレイテッドJuvic Inc. | 微細ルームマイクロ構造体及びその製造方法 |
EP3260160A4 (de) * | 2015-02-16 | 2018-09-05 | Toppan Printing Co., Ltd. | Mikronadel |
CN107405477B (zh) * | 2015-03-18 | 2020-06-16 | 凸版印刷株式会社 | 药剂施予装置及药剂施予装置的制造方法 |
EP3409318A4 (de) * | 2016-01-28 | 2019-01-23 | Ricoh Company, Ltd. | Mikronadelanordnung und mikronadelfeld |
JP2017176652A (ja) | 2016-03-31 | 2017-10-05 | 花王株式会社 | 微細中空突起具 |
CN105963855A (zh) * | 2016-06-22 | 2016-09-28 | 成都市亿泰科技有限公司 | 一种含分离式储药囊的微针给药贴片 |
CN105999533B (zh) * | 2016-06-30 | 2022-01-25 | 山东中医药大学附属医院 | 药物夹层敷贴袋 |
US20210128897A1 (en) * | 2017-08-17 | 2021-05-06 | New York University | Bone growth stimulator and methods of use |
TWI666036B (zh) * | 2017-10-27 | 2019-07-21 | 研能科技股份有限公司 | 穿戴式人體胰島素注入供液裝置 |
TWI657842B (zh) * | 2017-10-27 | 2019-05-01 | 研能科技股份有限公司 | 人體胰島素注入之供液裝置 |
TWI656893B (zh) * | 2017-10-27 | 2019-04-21 | 研能科技股份有限公司 | 穿戴式人體胰島素注入供液裝置 |
US11844919B2 (en) * | 2018-01-03 | 2023-12-19 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
JP7305311B2 (ja) | 2018-05-30 | 2023-07-10 | ロレアル | マイクロニードルシート |
JP7335061B2 (ja) | 2018-06-29 | 2023-08-29 | ロレアル | マイクロニードルシートを使用する美容方法 |
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JP2020018327A (ja) | 2018-07-17 | 2020-02-06 | ロレアル | マイクロニードルシート |
JP2020099513A (ja) | 2018-12-21 | 2020-07-02 | ロレアル | マイクロニードルシートを使用するキット及び美容方法 |
WO2020188484A1 (en) * | 2019-03-19 | 2020-09-24 | King Abdullah University Of Science And Technology | Miniaturized delivery system and method |
CN110478613B (zh) | 2019-08-22 | 2022-08-09 | 京东方科技集团股份有限公司 | 递送制剂的器件、设备及器件中针头阵列的制备方法 |
JP2021094146A (ja) | 2019-12-16 | 2021-06-24 | ロレアル | マイクロニードルシートを使用する美容方法 |
US20230024124A1 (en) * | 2019-12-20 | 2023-01-26 | Ares Trading S.A. | Microneedle array, actuator and method of use |
EP3854375A1 (de) | 2020-01-23 | 2021-07-28 | Paean Aesthetics Inc | Mikronadelzusammensetzung zur kontrolle ihrer form und verfahren zu ihrer herstellung |
US20230226332A1 (en) | 2020-06-17 | 2023-07-20 | L'oreal | Kit and cosmetic process using microneedle sheet |
FR3113843B1 (fr) | 2020-09-07 | 2024-03-15 | Oreal | Kit et traitement cosmetique utilisant une feuille de micro-aiguilles |
WO2022026764A1 (en) | 2020-07-29 | 2022-02-03 | Biolinq Inc. | Continuous analyte monitoring system with microneedle array |
DE102020133395A1 (de) | 2020-12-14 | 2022-06-15 | Lts Lohmann Therapie-Systeme Ag. | Wirkstoffabgabesystem |
SE545874C2 (en) | 2021-05-08 | 2024-02-27 | Biolinq Incorporated | Fault detection for microneedle array based continuous analyte monitoring device |
FR3135206A1 (fr) | 2022-05-05 | 2023-11-10 | L'oreal | Processus cosmétique utilisant une feuille de micro-aiguilles |
FR3139007A1 (fr) | 2022-08-23 | 2024-03-01 | L'oreal | Composition convenant pour des traitements cosmétiques de substance kératineuse |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
GB2221394A (en) * | 1988-08-05 | 1990-02-07 | Eilert Eilertsen | An injection device |
EP0513879A2 (de) * | 1984-10-12 | 1992-11-19 | Drug Delivery Systems Inc. | Vorrichtung zur transdermalen Applikation von Medikamenten |
DE19518974A1 (de) * | 1994-05-23 | 1995-11-30 | Samsung Electro Mech | Perforationsvorrichtung für Verabreichungen über die Haut |
-
1995
- 1995-07-14 DE DE19525607A patent/DE19525607A1/de not_active Withdrawn
-
1996
- 1996-07-10 TW TW085108368A patent/TW375528B/zh not_active IP Right Cessation
- 1996-07-11 UY UY24277A patent/UY24277A1/es not_active IP Right Cessation
- 1996-07-12 CO CO96036735A patent/CO4700491A1/es unknown
- 1996-07-12 AR ARP960103564A patent/AR004499A1/es unknown
- 1996-07-12 ZA ZA9605931A patent/ZA965931B/xx unknown
- 1996-07-15 MX MX9800401A patent/MX9800401A/es unknown
- 1996-07-15 WO PCT/EP1996/003090 patent/WO1997003718A1/de active IP Right Grant
- 1996-07-15 RU RU98102774/14A patent/RU2209640C2/ru not_active IP Right Cessation
- 1996-07-15 SK SK49-98A patent/SK284358B6/sk not_active IP Right Cessation
- 1996-07-15 NZ NZ313984A patent/NZ313984A/xx not_active IP Right Cessation
- 1996-07-15 DE DE59608081T patent/DE59608081D1/de not_active Expired - Lifetime
- 1996-07-15 PT PT96926348T patent/PT840634E/pt unknown
- 1996-07-15 US US08/983,197 patent/US6132755A/en not_active Expired - Lifetime
- 1996-07-15 RO RO98-00032A patent/RO118738B1/ro unknown
- 1996-07-15 CA CA002226718A patent/CA2226718C/en not_active Expired - Fee Related
- 1996-07-15 HU HU9802773A patent/HU222342B1/hu not_active IP Right Cessation
- 1996-07-15 CZ CZ1998118A patent/CZ290458B6/cs not_active IP Right Cessation
- 1996-07-15 JP JP9506273A patent/JPH11509123A/ja active Pending
- 1996-07-15 EP EP96926348A patent/EP0840634B1/de not_active Expired - Lifetime
- 1996-07-15 AU AU66567/96A patent/AU722943B2/en not_active Ceased
- 1996-07-15 UA UA98020771A patent/UA62918C2/uk unknown
- 1996-07-15 BR BR9609796A patent/BR9609796A/pt not_active IP Right Cessation
- 1996-07-15 KR KR10-1998-0700268A patent/KR100430703B1/ko not_active IP Right Cessation
- 1996-07-15 DK DK96926348T patent/DK0840634T3/da active
- 1996-07-15 TR TR1998/00048T patent/TR199800048T1/xx unknown
- 1996-07-15 CN CNB96195485XA patent/CN1183979C/zh not_active Expired - Fee Related
- 1996-07-15 IL IL12290796A patent/IL122907A0/xx not_active IP Right Cessation
- 1996-07-15 PL PL96324530A patent/PL181658B1/pl unknown
- 1996-07-15 ES ES96926348T patent/ES2163035T3/es not_active Expired - Lifetime
- 1996-07-15 EE EE9800025A patent/EE04006B1/xx unknown
- 1996-07-15 AT AT96926348T patent/ATE207769T1/de active
-
1998
- 1998-01-13 NO NO19980147A patent/NO316313B1/no not_active IP Right Cessation
- 1998-01-20 BG BG102200A patent/BG63142B1/bg unknown
- 1998-11-09 HK HK98111847A patent/HK1010844A1/xx not_active IP Right Cessation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
EP0513879A2 (de) * | 1984-10-12 | 1992-11-19 | Drug Delivery Systems Inc. | Vorrichtung zur transdermalen Applikation von Medikamenten |
GB2221394A (en) * | 1988-08-05 | 1990-02-07 | Eilert Eilertsen | An injection device |
DE19518974A1 (de) * | 1994-05-23 | 1995-11-30 | Samsung Electro Mech | Perforationsvorrichtung für Verabreichungen über die Haut |
Cited By (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
JP2009119296A (ja) * | 1998-06-10 | 2009-06-04 | Georgia Tech Research Corp | 微小針デバイスおよび製造方法ならびにそれらの使用 |
JP2002521222A (ja) * | 1998-07-22 | 2002-07-16 | イギリス国 | ダクトを有するシリコンの微細加工突起 |
JP4672142B2 (ja) * | 1998-07-22 | 2011-04-20 | キネティック リミテッド | ダクトを有するシリコンの微細加工突起 |
EP1113832A4 (de) * | 1998-09-18 | 2002-04-17 | Univ Utah Res Found | Mikronadel mit mikromechanisch bearbeiteter oberfläche |
EP1113832A1 (de) * | 1998-09-18 | 2001-07-11 | University of Utah Research Foundation | Mikronadel mit mikromechanisch bearbeiteter oberfläche |
US7048723B1 (en) * | 1998-09-18 | 2006-05-23 | The University Of Utah Research Foundation | Surface micromachined microneedles |
US6451240B1 (en) | 1999-06-09 | 2002-09-17 | The Procter & Gamble Company | Method of manufacturing an intracutaneous microneedle array |
US6931277B1 (en) | 1999-06-09 | 2005-08-16 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6471903B2 (en) | 1999-06-09 | 2002-10-29 | The Procter & Gamble Company | Method for manufacturing an intracutaneous microneedle array |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
JP2003501163A (ja) * | 1999-06-09 | 2003-01-14 | ザ プロクター アンド ギャンブル カンパニー | 皮内用刃状ミクロ針構造体 |
US6379324B1 (en) | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
WO2000074765A1 (en) * | 1999-06-09 | 2000-12-14 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6652478B1 (en) | 1999-06-09 | 2003-11-25 | The Procter & Gamble Company | Intracutaneous edged microneedle apparatus |
WO2000074766A1 (en) * | 1999-06-09 | 2000-12-14 | The Procter & Gamble Company | Intracutaneous edged microneedle structure |
SG92728A1 (en) * | 1999-09-22 | 2002-11-19 | Becton Dickinson Co | Method and apparatus for the transdermal administration of a substrate |
US6835184B1 (en) | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
EP1086719A1 (de) * | 1999-09-24 | 2001-03-28 | Becton Dickinson and Company | Methode und Vorrichtung zum Abscheuern der Haut |
WO2001041864A1 (en) | 1999-12-10 | 2001-06-14 | Alza Corporation | Skin treatment apparatus for sustained transdermal drug delivery |
US7087035B2 (en) | 1999-12-10 | 2006-08-08 | Alza Corporation | Device and method for enhancing skin piercing by microprotrusions |
WO2001052731A1 (en) * | 2000-01-21 | 2001-07-26 | Instrumentarium Corporation | Medical electrode |
US7731968B2 (en) | 2000-05-22 | 2010-06-08 | Becton, Dickinson And Company | Topical delivery of vaccines |
US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
WO2002002180A3 (en) * | 2000-06-29 | 2002-05-02 | Becton Dickinson Co | Method and apparatus for transdermally sampling or administering a substance to a patient |
US6589202B1 (en) | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
US6565532B1 (en) | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
WO2002005889A1 (en) * | 2000-07-17 | 2002-01-24 | Becton, Dickinson And Company | Delivery device with microneedles for the transdermal administration of a substance |
US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
WO2002007813A1 (en) * | 2000-07-21 | 2002-01-31 | Smithkline Beecham Biologicals S.A. | Vaccines |
EP1512429A1 (de) * | 2000-07-21 | 2005-03-09 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Mit Impfstoff beschichtete Nadeln |
US7438926B2 (en) | 2000-09-08 | 2008-10-21 | Alza Corporation | Methods for inhibiting decrease in transdermal drug flux by inhibition of pathway closure |
WO2002030506A3 (en) * | 2000-10-12 | 2002-08-15 | Ink Jet Tech Ltd | Transdermal method |
US7131960B2 (en) | 2000-10-13 | 2006-11-07 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US9192749B2 (en) | 2000-10-13 | 2015-11-24 | Alza Corporation | Microblade array impact applicator |
US7798987B2 (en) | 2000-10-13 | 2010-09-21 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US7419481B2 (en) | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
US6855131B2 (en) | 2000-10-13 | 2005-02-15 | Alza Corporation | Microprotrusion member retainer for impact applicator |
JP2004521669A (ja) * | 2000-10-16 | 2004-07-22 | ザ プロクター アンド ギャンブル カンパニー | 皮膚処理及びコンディショニング用微細構造 |
WO2002032480A2 (en) * | 2000-10-16 | 2002-04-25 | The Procter & Gamble Company | Microstructures for delivering a composition cutaneously to skin |
WO2002032331A2 (en) * | 2000-10-16 | 2002-04-25 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
WO2002032480A3 (en) * | 2000-10-16 | 2002-08-29 | Procter & Gamble | Microstructures for delivering a composition cutaneously to skin |
US6821281B2 (en) | 2000-10-16 | 2004-11-23 | The Procter & Gamble Company | Microstructures for treating and conditioning skin |
WO2002032331A3 (en) * | 2000-10-16 | 2002-09-06 | Procter & Gamble | Microstructures for treating and conditioning skin |
US7537795B2 (en) | 2000-10-26 | 2009-05-26 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
US8663155B2 (en) | 2000-10-26 | 2014-03-04 | Alza Corporation | Transdermal drug delivery devices having coated microprotrusions |
EP2085109A2 (de) | 2000-10-26 | 2009-08-05 | Alza Corporation | Transdermale Arzneimittelverabreichungsvorrichtungen mit beschichteten Mikrovorsprüngen |
US7569032B2 (en) | 2000-11-28 | 2009-08-04 | Boston Scientific Scimed, Inc. | Medical device for delivery of a biologically active material to a lumen |
US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
US6855372B2 (en) | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
US7435299B2 (en) | 2001-03-16 | 2008-10-14 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
EP3251722A1 (de) | 2001-04-20 | 2017-12-06 | ALZA Corporation | Mikroprojektionsanordnung mit einer beschichtung, der ein vorteilhaftes mittel enthält und beschichtungsverfahren dafuer |
US7963935B2 (en) | 2001-04-20 | 2011-06-21 | Alza Corporation | Microprojection array having a beneficial agent containing coating |
US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
US6908453B2 (en) | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
US7858112B2 (en) | 2002-02-28 | 2010-12-28 | Lintec Corporation | Percutaneous absorption system and percutaneous absorption method |
WO2003080174A1 (fr) * | 2002-03-26 | 2003-10-02 | Juridical Foundation Osaka Industrial Promotion Organization | Systeme de traitement medical et procede de production destine a ce systeme |
US7047070B2 (en) | 2002-04-02 | 2006-05-16 | Becton, Dickinson And Company | Valved intradermal delivery device and method of intradermally delivering a substance to a patient |
US6780171B2 (en) | 2002-04-02 | 2004-08-24 | Becton, Dickinson And Company | Intradermal delivery device |
US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
US7828827B2 (en) | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
US8900194B2 (en) | 2002-07-19 | 2014-12-02 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
US7579013B2 (en) | 2003-06-30 | 2009-08-25 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
WO2005004842A2 (en) | 2003-06-30 | 2005-01-20 | Alza Corporation | Formulations for coated microprojections containing non-volatile counterions |
WO2005042054A2 (en) | 2003-10-24 | 2005-05-12 | Alza Corporation | Pretreatment method and system for enhancing transdermal drug delivery |
US7455654B2 (en) | 2003-10-28 | 2008-11-25 | Alza Corporation | Method and apparatus for reducing the incidence of tobacco use |
US7097631B2 (en) | 2003-10-31 | 2006-08-29 | Alza Corporation | Self-actuating applicator for microprojection array |
US9421351B2 (en) | 2003-10-31 | 2016-08-23 | Alza Corporation | Self-actuating applicator for microprojection array |
CN100402107C (zh) * | 2004-03-31 | 2008-07-16 | 中国科学院理化技术研究所 | 金属微针阵列芯片及其制备方法和用途 |
EP1669100A1 (de) * | 2004-12-13 | 2006-06-14 | Debiotech S.A. | Micro-aiguilles |
US10238848B2 (en) | 2007-04-16 | 2019-03-26 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US8911749B2 (en) | 2007-04-16 | 2014-12-16 | Corium International, Inc. | Vaccine delivery via microneedle arrays |
US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US9452280B2 (en) | 2007-04-16 | 2016-09-27 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
US9498524B2 (en) | 2007-04-16 | 2016-11-22 | Corium International, Inc. | Method of vaccine delivery via microneedle arrays |
US11419816B2 (en) | 2010-05-04 | 2022-08-23 | Corium, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
US9687641B2 (en) | 2010-05-04 | 2017-06-27 | Corium International, Inc. | Method and device for transdermal delivery of parathyroid hormone using a microprojection array |
CN101905856A (zh) * | 2010-06-11 | 2010-12-08 | 北京大学 | 一种用于透皮给药的平面空心微针的制备方法 |
US11052231B2 (en) | 2012-12-21 | 2021-07-06 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10245422B2 (en) | 2013-03-12 | 2019-04-02 | Corium International, Inc. | Microprojection applicators and methods of use |
US11110259B2 (en) | 2013-03-12 | 2021-09-07 | Corium, Inc. | Microprojection applicators and methods of use |
US10195409B2 (en) | 2013-03-15 | 2019-02-05 | Corium International, Inc. | Multiple impact microprojection applicators and methods of use |
US9962534B2 (en) | 2013-03-15 | 2018-05-08 | Corium International, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
US11565097B2 (en) | 2013-03-15 | 2023-01-31 | Corium Pharma Solutions, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10384046B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray for delivery of therapeutic agent and methods of use |
US10384045B2 (en) | 2013-03-15 | 2019-08-20 | Corium, Inc. | Microarray with polymer-free microstructures, methods of making, and methods of use |
WO2015017561A1 (en) | 2013-07-30 | 2015-02-05 | Zosano Pharma, Inc. | Low-profile microneedle patch applicator |
WO2016008845A1 (de) * | 2014-07-15 | 2016-01-21 | Lts Lohmann Therapie-Systeme Ag | Zylinder-kolben-einheit mit kanülen |
EP2974758A1 (de) * | 2014-07-15 | 2016-01-20 | LTS LOHMANN Therapie-Systeme AG | Zylinder-Kolben-Einheit mit Kanülen |
US10624843B2 (en) | 2014-09-04 | 2020-04-21 | Corium, Inc. | Microstructure array, methods of making, and methods of use |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
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