WO1996040093A3 - Bis phenol or phenozy compounds for immune modulation - Google Patents

Bis phenol or phenozy compounds for immune modulation Download PDF

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Publication number
WO1996040093A3
WO1996040093A3 PCT/JP1996/001552 JP9601552W WO9640093A3 WO 1996040093 A3 WO1996040093 A3 WO 1996040093A3 JP 9601552 W JP9601552 W JP 9601552W WO 9640093 A3 WO9640093 A3 WO 9640093A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune
chemical agents
phenozy
compounds
immune modulation
Prior art date
Application number
PCT/JP1996/001552
Other languages
French (fr)
Other versions
WO1996040093A2 (en
Inventor
Stephen D Gillies
John Wesolowski
Original Assignee
Fuji Photo Film Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Photo Film Co Ltd filed Critical Fuji Photo Film Co Ltd
Priority to AU59114/96A priority Critical patent/AU5911496A/en
Publication of WO1996040093A2 publication Critical patent/WO1996040093A2/en
Publication of WO1996040093A3 publication Critical patent/WO1996040093A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols

Abstract

Disclosed are chemical agents for modulating certain cellular immune reactions that can lead to autoimmune disorders. By specific modulation, harmful immune reactions can be lessened in severity or even prevented without resorting to potentially dangerous general immune suppression. The described chemical agents inhibit IL-12 induction of the secretion of key immune modulators. The described chemical agents are specific inhibitors of IL-12 induced Th1 immune response.
PCT/JP1996/001552 1995-06-07 1996-06-07 Bis phenol or phenozy compounds for immune modulation WO1996040093A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59114/96A AU5911496A (en) 1995-06-07 1996-06-07 Bis phenol or phenozy compounds for immune modulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/473,364 US5880146A (en) 1995-06-07 1995-06-07 Inhibition of IL-12-induced IFN-γ synthesis by specific bis-phenol compounds as a method of immune modulation
US08/473,364 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040093A2 WO1996040093A2 (en) 1996-12-19
WO1996040093A3 true WO1996040093A3 (en) 1997-03-13

Family

ID=23879237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/001552 WO1996040093A2 (en) 1995-06-07 1996-06-07 Bis phenol or phenozy compounds for immune modulation

Country Status (3)

Country Link
US (1) US5880146A (en)
AU (1) AU5911496A (en)
WO (1) WO1996040093A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6054487A (en) * 1997-03-18 2000-04-25 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
DE69927520T2 (en) * 1998-12-09 2006-06-22 Protein Design Labs, Inc., Fremont USE OF IL-12 ANTIBODIES FOR THE TREATMENT OF PSORIASIS
US7329489B2 (en) * 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US8849577B2 (en) * 2006-09-15 2014-09-30 Metabolon, Inc. Methods of identifying biochemical pathways
GB0705179D0 (en) * 2007-03-17 2007-04-25 Syntopix Ltd Formulations
PT2152663E (en) * 2007-06-04 2014-06-03 Univ Ben Gurion Tri-aryl compounds and compositions comprising the same
EA201491011A1 (en) 2011-11-23 2014-09-30 Амген Инк. METHODS OF TREATMENT BY MEANS OF THE GAMMA INTERFERON INHIBITOR

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583665A2 (en) * 1992-07-30 1994-02-23 Fuji Photo Film Co., Ltd. Pharmaceutical composition and method for treating hyperlipidemia and arteriosclerosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE369383T1 (en) * 1989-12-22 2007-08-15 Hoffmann La Roche MONOCLONAL ANTIBODIES SPECIFIC TO THE CYTOTOXIC LYMPHOCYTE MATURATION FACTOR
DE59108814D1 (en) * 1990-09-05 1997-09-11 Ciba Geigy Ag Diphenyl compounds inhibiting arachidonic acid metabolism and their use in pharmaceutical compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0583665A2 (en) * 1992-07-30 1994-02-23 Fuji Photo Film Co., Ltd. Pharmaceutical composition and method for treating hyperlipidemia and arteriosclerosis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CORREALE, J. ET AL: "Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis", JOURNAL OF IMMUNOLOGY, vol. 154, 15 March 1995 (1995-03-15), pages 2959 - 68, XP000616368 *
GERMANN, T. ET AL: "Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice", PROC. NATL. ACAD. SCI. USA, vol. 92, 23 May 1995 (1995-05-23), pages 4823 - 4827, XP000616366 *
JONTELL, M. ET AL: "Effects of unpolymerized resin components on the function of accessory cells derived from the rat incisor pulp", JOURNAL OF DENTAL RESEARCH, vol. 74, no. 5, May 1995 (1995-05-01), pages 1162 - 1167, XP000617048 *
NISHIYAMA, TOMIHIRO ET AL: "Antioxidant activity of the Fused heterocyclic compounds, 9H-Xanthene-2,7-diols", YUKAGAKU (JOURNAL JAPANESE OIL CHEM. SOC.), vol. 44, no. 11, 1995, pages 960 - 965, XP000617064 *
THE IFNB MS STUDY GROUP: "Interferon beta-1b is effective in relapsing-remitting multiple sclerosis", NEUROLOGY, vol. 43, no. 4, April 1993 (1993-04-01), pages 655 - 661, XP000614982 *

Also Published As

Publication number Publication date
WO1996040093A2 (en) 1996-12-19
US5880146A (en) 1999-03-09
AU5911496A (en) 1996-12-30

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