WO1996006679A1 - Centrifuge syringe apparatus and method - Google Patents
Centrifuge syringe apparatus and method Download PDFInfo
- Publication number
- WO1996006679A1 WO1996006679A1 PCT/US1995/011162 US9511162W WO9606679A1 WO 1996006679 A1 WO1996006679 A1 WO 1996006679A1 US 9511162 W US9511162 W US 9511162W WO 9606679 A1 WO9606679 A1 WO 9606679A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plunger
- fluid
- container
- cell
- syringe
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000000926 separation method Methods 0.000 claims abstract description 42
- 239000012530 fluid Substances 0.000 claims abstract description 41
- 238000005119 centrifugation Methods 0.000 claims abstract description 29
- 238000004458 analytical method Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 2
- 239000008188 pellet Substances 0.000 abstract description 10
- 238000002156 mixing Methods 0.000 abstract description 9
- 239000012620 biological material Substances 0.000 abstract description 2
- 239000012134 supernatant fraction Substances 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 46
- 239000000463 material Substances 0.000 description 45
- 239000000523 sample Substances 0.000 description 18
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 6
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000012071 phase Substances 0.000 description 5
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 4
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 238000002617 apheresis Methods 0.000 description 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010029961 Filgrastim Proteins 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000000998 lymphohematopoietic effect Effects 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940029345 neupogen Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002198606A CA2198606C (en) | 1994-08-31 | 1995-08-31 | Centrifuge syringe apparatus and method |
NZ292754A NZ292754A (en) | 1994-08-31 | 1995-08-31 | Centrifugable syringe for density-gradient separation of cells, chamber with constricted entrance at plunger face |
EP95931683A EP0778794B1 (en) | 1994-08-31 | 1995-08-31 | Centrifuge syringe apparatus and method |
DK95931683T DK0778794T3 (en) | 1994-08-31 | 1995-08-31 | Centrifuge syringe apparatus and method |
JP50898496A JP3487604B2 (en) | 1994-08-31 | 1995-08-31 | Centrifugal syringe device and method |
AU35023/95A AU680383B2 (en) | 1994-08-31 | 1995-08-31 | Centrifuge syringe apparatus and method |
DE69503512T DE69503512T2 (en) | 1994-08-31 | 1995-08-31 | CENTRIFUGAL SPRAYER AND METHOD |
HK98115107A HK1013807A1 (en) | 1994-08-31 | 1998-12-23 | Centrifuge syringe apparatus and method |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/298,882 | 1994-08-31 | ||
US08/298,882 US5577513A (en) | 1994-08-31 | 1994-08-31 | Centrifugation syringe, system and method |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996006679A1 true WO1996006679A1 (en) | 1996-03-07 |
Family
ID=23152384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/011162 WO1996006679A1 (en) | 1994-08-31 | 1995-08-31 | Centrifuge syringe apparatus and method |
Country Status (12)
Country | Link |
---|---|
US (1) | US5577513A (en) |
EP (1) | EP0778794B1 (en) |
JP (1) | JP3487604B2 (en) |
AT (1) | ATE168288T1 (en) |
AU (1) | AU680383B2 (en) |
CA (1) | CA2198606C (en) |
DE (1) | DE69503512T2 (en) |
DK (1) | DK0778794T3 (en) |
ES (1) | ES2121414T3 (en) |
HK (1) | HK1013807A1 (en) |
NZ (1) | NZ292754A (en) |
WO (1) | WO1996006679A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010014033A1 (en) * | 2008-07-31 | 2010-02-04 | Ge Healthcare Bio-Sciences Ab | Separation device |
US9097631B2 (en) | 2008-12-01 | 2015-08-04 | Baxter International Inc. | Apparatus and method for processing biological material |
US9199250B2 (en) | 2009-05-01 | 2015-12-01 | Trustees Of Boston University | Disposable separator/concentrator device and method of use |
CN110832061A (en) * | 2017-10-06 | 2020-02-21 | 史蒂芬.何 | Device and method for collecting and separating cells |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19681033D2 (en) | 1995-11-16 | 1999-03-18 | Michael W Dahm | Method for the quantification of tumor cells in a body fluid and suitable test kits |
DE19804372A1 (en) | 1998-02-04 | 1999-08-05 | Michael W Dr Dr Dahm | Method for the quantitative determination of tumor cells in a body fluid and suitable test kits |
DE19904267A1 (en) * | 1999-02-03 | 2000-08-10 | Michael W Dahm | Method for the enrichment of tumor cells from a body fluid and a suitable kit for this |
US7947236B2 (en) | 1999-12-03 | 2011-05-24 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
JP4890670B2 (en) * | 2000-03-24 | 2012-03-07 | ベックマン コールター, インコーポレイテッド | Liquid dispensing device |
ATE382408T1 (en) | 2000-04-28 | 2008-01-15 | Harvest Technologies Corp | PLATE SEPARATION DEVICE FOR BLOOD COMPONENTS |
US6387030B1 (en) * | 2000-06-30 | 2002-05-14 | Beckman Coulter, Inc. | Internal adapter with a pellet well for a centrifuge container |
US6913580B2 (en) * | 2001-01-23 | 2005-07-05 | Benjamin Curtis Stone | Method of body fluid specimen collection |
WO2002067778A2 (en) * | 2001-02-26 | 2002-09-06 | Ben-Ami Ballin | Syringe for use in blood analysis |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US20030205538A1 (en) * | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
WO2003099412A1 (en) | 2002-05-24 | 2003-12-04 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US20040044316A1 (en) * | 2002-08-30 | 2004-03-04 | Greenfield Christian John | Syringe for sequential delivery of different fluids |
US7077827B2 (en) * | 2002-08-30 | 2006-07-18 | Christian John Greenfield | Syringe for sequential delivery of different fluids |
CN1822903B (en) * | 2003-05-19 | 2012-04-18 | 丰收技术股份有限公司 | Method and apparatus for separating fluid components |
JP2005333852A (en) * | 2004-05-25 | 2005-12-08 | Kenichiro Hatake | Liquid-collecting device and method for culturing cell |
US20060018799A1 (en) * | 2004-07-21 | 2006-01-26 | Wong Cai Ne W | Universal tissue homogenizer device and methods |
US8182806B2 (en) * | 2004-09-07 | 2012-05-22 | Johnson Lanny L | Synovial villi for use with tissue engineering |
US7708152B2 (en) | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
WO2006086199A1 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8197420B2 (en) | 2006-12-18 | 2012-06-12 | Magnolia Medical Technologies, Inc. | Systems and methods for parenterally procuring bodily-fluid samples with reduced contamination |
WO2008127639A1 (en) | 2007-04-12 | 2008-10-23 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
PL2259774T3 (en) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
WO2009111338A1 (en) | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
EP2303457B1 (en) | 2008-07-21 | 2019-08-28 | Becton, Dickinson and Company | Density phase separation device |
US8177072B2 (en) * | 2008-12-04 | 2012-05-15 | Thermogenesis Corp. | Apparatus and method for separating and isolating components of a biological fluid |
US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
ES2731704T3 (en) | 2009-05-15 | 2019-11-18 | Becton Dickinson Co | Density Phase Separation Device |
US9272083B2 (en) | 2009-05-29 | 2016-03-01 | Endocellutions, Inc. | Apparatus and methods for aspirating and separating components of different densities from a physiological fluid containing cells |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
US7927563B1 (en) * | 2009-10-13 | 2011-04-19 | Cytomedix, Inc. | Kit for separation of biological fluids |
KR101069877B1 (en) * | 2009-10-28 | 2011-10-05 | 임기표 | Kit of centrifuge separation and methods for centrifuging using the same |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
EP2815776B1 (en) | 2011-06-13 | 2016-02-03 | Terumo BCT, Inc. | System for blood separation with gravity valve for controlling a side-tapped separation chamber |
US8535241B2 (en) | 2011-10-13 | 2013-09-17 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
US8864684B2 (en) | 2011-10-13 | 2014-10-21 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
US9060724B2 (en) | 2012-05-30 | 2015-06-23 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
US9022951B2 (en) | 2012-05-30 | 2015-05-05 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
EP2877577A4 (en) * | 2012-07-27 | 2016-02-10 | Bioquark Inc | Extracts isolated from electroporated amphibian oocytes and use thereof in treating diseases and disorders |
WO2014022275A1 (en) | 2012-08-01 | 2014-02-06 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
EP3318295B1 (en) | 2012-10-11 | 2021-04-14 | Magnolia Medical Technologies, Inc. | System for delivering a fluid to a patient with reduced contamination |
CN109171766A (en) | 2012-11-30 | 2019-01-11 | 木兰医药技术股份有限公司 | Body fluid barrier means and the method for completely cutting off body fluid using body fluid barrier means |
WO2014085456A1 (en) * | 2012-11-30 | 2014-06-05 | Rarecyte, Inc. | Apparatus, system, and method for collecting a target material |
US10772548B2 (en) | 2012-12-04 | 2020-09-15 | Magnolia Medical Technologies, Inc. | Sterile bodily-fluid collection device and methods |
EP4218575A3 (en) | 2012-12-04 | 2023-09-06 | Magnolia Medical Technologies, Inc. | Sterile bodily-fluid collection device and methods |
US10603665B2 (en) | 2013-01-29 | 2020-03-31 | Endocellutions, Inc. | Cell concentration devices and methods that include an insert defining a lumen and a cannula assembly |
EP2956187B1 (en) | 2013-02-18 | 2017-11-01 | Terumo BCT, Inc. | System for blood separation with a separation chamber having an internal gravity valve |
CN105188534B (en) | 2013-03-12 | 2018-05-29 | 木兰医药技术股份有限公司 | For selectively blocking the device and method of the tube chamber of needle body |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US10618060B2 (en) | 2013-12-20 | 2020-04-14 | Terumo Bct, Inc. | Centrifuge safety mechanism |
GB2524004A (en) * | 2014-03-10 | 2015-09-16 | Stratec Biomedical Ag | Dispenser |
WO2016025914A1 (en) | 2014-08-14 | 2016-02-18 | Terumo Bct, Inc. | Processing particles |
US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
EP3100710A1 (en) * | 2015-06-03 | 2016-12-07 | Medical Biobank Swiss Institute SA/AG (MBSI) | Syringe for cell isolation |
US11234626B2 (en) | 2015-06-12 | 2022-02-01 | Magnolia Medical Technologies, Inc. | Devices and methods for syringe-based fluid transfer for bodily-fluid sampling |
EP3733067B1 (en) | 2015-09-03 | 2023-06-14 | Magnolia Medical Technologies, Inc. | System for maintaining sterility of a specimen container |
US10039882B2 (en) * | 2016-09-01 | 2018-08-07 | Arthrex, Inc. | Binding syringe |
CN107008518B (en) * | 2017-04-12 | 2019-08-09 | 郝大勇 | Centrifuge tube, centrifuge tube adapter and the method for extracting sample |
US11345892B2 (en) | 2017-05-18 | 2022-05-31 | Herbert A F Larsen | Centrifugal syringe and method for blood fractionation |
CN116250868A (en) | 2017-09-12 | 2023-06-13 | 木兰医药技术股份有限公司 | Fluid control device and method of using the same |
US20210220817A1 (en) * | 2018-12-08 | 2021-07-22 | Min Wei | Apparatus For Manufacturing Cell Therapy Product |
US11559613B2 (en) | 2019-02-06 | 2023-01-24 | Hanuman Pelican, Inc. | Apparatus and methods for concentrating platelet-rich plasma |
EP3920801A1 (en) | 2019-02-08 | 2021-12-15 | Magnolia Medical Technologies, Inc. | Devices and methods for bodily fluid collection and distribution |
CN113784793B (en) | 2019-03-11 | 2023-09-19 | 木兰医药技术股份有限公司 | Fluid control device and method of using the same |
WO2020196412A1 (en) * | 2019-03-26 | 2020-10-01 | テルモ株式会社 | Centrifuge member and cleaning method |
US11964286B2 (en) | 2019-04-12 | 2024-04-23 | Terumo Bct, Inc. | Cell washing chamber for blood processing centrifuge |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1014348B (en) * | 1952-01-08 | 1957-08-22 | Anschuetz & Co Gmbh | Radial tube centrifuge |
US3741400A (en) * | 1970-06-15 | 1973-06-26 | J Dick | Blood sample container |
FR2556096A1 (en) * | 1983-12-05 | 1985-06-07 | Sarstedt Kunststoff | DEVICE FOR INTERCALATING A SEPARATION GEL BETWEEN TWO PHASES PLACED IN A TUBE TEST |
US4707276A (en) * | 1981-04-15 | 1987-11-17 | Sherwood Medical Company | Fluid collection device with phase partitioning means |
DE4101952A1 (en) * | 1991-01-19 | 1992-07-23 | Ff Diagnostic Vertrieb Gmbh | Test tube and pipette for centrifuging liq. samples - has tube of reduced diameter at short distance above lower end which retains liq. contg. solid particles after centrifuging |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3441205A (en) * | 1966-10-10 | 1969-04-29 | Marvin Kendall Young Jr | Method for separating sediment from supernatant fluid |
US3513976A (en) * | 1968-03-19 | 1970-05-26 | William C James | Leukocyte flask and method of obtaining white cells from whole blood |
US3750645A (en) * | 1970-10-20 | 1973-08-07 | Becton Dickinson Co | Method of collecting blood and separating cellular components thereof |
US3706305A (en) * | 1971-03-03 | 1972-12-19 | Harold J Berger | Combination blood sampling vacuum syringe centrifuge container and specimen cup |
US3706306A (en) * | 1971-03-03 | 1972-12-19 | Harold J Berger | Combination blood sampling vacuum syringe centrifuge container and specimen cup |
US3965889A (en) * | 1971-11-26 | 1976-06-29 | Commissariat A L'energie Atomique | Apparatus for the sampling of blood and the separation of plasma under anaerobic conditions |
US3849072A (en) * | 1972-04-25 | 1974-11-19 | Becton Dickinson Co | Plasma separator |
DE7239445U (en) * | 1972-10-27 | 1973-08-02 | Merten Utz P | Disposable syringes, especially for taking blood samples |
US4001122A (en) * | 1973-08-22 | 1977-01-04 | Telan Corporation | Method and device for separating blood components |
US3957654A (en) * | 1974-02-27 | 1976-05-18 | Becton, Dickinson And Company | Plasma separator with barrier to eject sealant |
US3985122A (en) * | 1975-06-04 | 1976-10-12 | Medical Development Corporation | Multi-piston syringe device |
US4022576A (en) * | 1975-06-09 | 1977-05-10 | I. C. L. Scientific | Method and apparatus for preparation of liquids containing suspended material for examination |
US4020831A (en) * | 1975-12-04 | 1977-05-03 | Technicon Instruments Corporation | Blood collecting syringe |
US4055501A (en) * | 1976-01-16 | 1977-10-25 | Sherwood Medical Industries Inc. | Fluid collection device with phase partitioning means |
CA1074273A (en) * | 1976-05-06 | 1980-03-25 | Sherwood Medical Industries Inc. | Phase separation device |
US4040959A (en) * | 1976-06-22 | 1977-08-09 | Berman Irwin R | Multi-purpose blood bag |
US4066414A (en) * | 1977-02-15 | 1978-01-03 | Donald Selby | One piece tube and microscope slide manipulative laboratory device |
US4112924A (en) * | 1977-04-07 | 1978-09-12 | Louis Thomas Ferrara | Blood collection valve |
US4134512A (en) * | 1977-06-08 | 1979-01-16 | Becton, Dickinson And Company | One-way evacuated tube stopper |
US4213456A (en) * | 1978-01-07 | 1980-07-22 | Bottger Paul E K | Medical multi-purpose instrument |
US4147628A (en) * | 1978-01-23 | 1979-04-03 | Becton, Dickinson And Company | Blood partitioning method |
US4181700A (en) * | 1978-04-03 | 1980-01-01 | Beckman Instruments, Inc. | Centrifuge tube sequential fractionator |
US4569764A (en) * | 1979-04-20 | 1986-02-11 | Sherwood Medical Company | Collection device with phase partitioning means |
DE2948653C2 (en) * | 1979-12-04 | 1984-01-05 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | Blood collection device |
US4256120A (en) * | 1980-01-07 | 1981-03-17 | Sherwood Medical Industries Inc. | Fluid sample collection device |
JPS57190567A (en) * | 1981-05-20 | 1982-11-24 | Terumo Corp | Blood sampler with air removing and shielding mechanism |
US4373535A (en) * | 1981-08-17 | 1983-02-15 | Martell Michael D | Venting, self-stopping, aspirating syringe |
AU552883B2 (en) * | 1981-11-03 | 1986-06-26 | Walter Sarstedt Kunststoff-Spritzgusswerk | Blood extracting and centrifuging device |
US4443345A (en) * | 1982-06-28 | 1984-04-17 | Wells John R | Serum preparator |
US4511349A (en) * | 1982-07-06 | 1985-04-16 | Beckman Instruments, Inc. | Ultracentrifuge tube with multiple chambers |
US4610846A (en) * | 1983-08-18 | 1986-09-09 | Hans Martin | Compartmentalized centrifugation chamber |
US4666850A (en) * | 1983-10-28 | 1987-05-19 | Becton, Dickinson And Company | Microbial pathogen detecting system and process |
US4562844A (en) * | 1984-11-27 | 1986-01-07 | Jett Labs, Inc. | Multipurpose syringe |
US5053134A (en) * | 1984-12-04 | 1991-10-01 | Becton Dickinson And Company | Lymphocyte collection tube |
US4917801A (en) * | 1984-12-04 | 1990-04-17 | Becton Dickinson And Company | Lymphocyte collection tube |
IL74967A (en) * | 1985-04-18 | 1988-10-31 | Assaf Pharmaceutical Ind | Separation of materials from a liquid dispersion by sedimentation |
US5132232A (en) * | 1985-07-30 | 1992-07-21 | V-Tech, Inc. | Method and apparatus for preparation of liquids for examination |
US4828716A (en) * | 1987-04-03 | 1989-05-09 | Andronic Devices, Ltd. | Apparatus and method for separating phases of blood |
US5030341A (en) * | 1987-04-03 | 1991-07-09 | Andronic Technologies, Inc. | Apparatus for separating phases of blood |
US4844818A (en) * | 1987-10-23 | 1989-07-04 | Becton Dickinson & Company | Method for separating the cellular components of blood samples |
US4957638A (en) * | 1987-10-23 | 1990-09-18 | Becton Dickinson And Company | Method for separating the cellular components of blood samples |
US4954264A (en) * | 1989-02-02 | 1990-09-04 | Becton-Dickinson And Company | Apparatus for separating mononuclear cells from blood and method of manufacturing and using the same |
US5039401A (en) * | 1990-05-16 | 1991-08-13 | Eastman Kodak Company | Blood collection and centrifugal separation device including a valve |
US5236604A (en) * | 1991-05-29 | 1993-08-17 | Sherwood Medical Company | Serum separation blood collection tube and the method of using thereof |
US5269927A (en) * | 1991-05-29 | 1993-12-14 | Sherwood Medical Company | Separation device for use in blood collection tubes |
US5271852A (en) * | 1992-05-01 | 1993-12-21 | E. I. Du Pont De Nemours And Company | Centrifugal methods using a phase-separation tube |
US5248480A (en) * | 1992-05-28 | 1993-09-28 | Diasys Corporation | Apparatus for drawing fluid sample and components thereof |
US5342790A (en) * | 1992-10-30 | 1994-08-30 | Becton Dickinson And Company | Apparatus for indirect fluorescent assay of blood samples |
JP3397795B2 (en) * | 1994-08-31 | 2003-04-21 | デンドレオン コーポレイション | Cell separation device and method |
-
1994
- 1994-08-31 US US08/298,882 patent/US5577513A/en not_active Expired - Lifetime
-
1995
- 1995-08-31 CA CA002198606A patent/CA2198606C/en not_active Expired - Lifetime
- 1995-08-31 NZ NZ292754A patent/NZ292754A/en not_active IP Right Cessation
- 1995-08-31 EP EP95931683A patent/EP0778794B1/en not_active Expired - Lifetime
- 1995-08-31 WO PCT/US1995/011162 patent/WO1996006679A1/en active IP Right Grant
- 1995-08-31 ES ES95931683T patent/ES2121414T3/en not_active Expired - Lifetime
- 1995-08-31 AU AU35023/95A patent/AU680383B2/en not_active Expired
- 1995-08-31 JP JP50898496A patent/JP3487604B2/en not_active Expired - Lifetime
- 1995-08-31 DE DE69503512T patent/DE69503512T2/en not_active Expired - Lifetime
- 1995-08-31 AT AT95931683T patent/ATE168288T1/en active
- 1995-08-31 DK DK95931683T patent/DK0778794T3/en active
-
1998
- 1998-12-23 HK HK98115107A patent/HK1013807A1/en not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1014348B (en) * | 1952-01-08 | 1957-08-22 | Anschuetz & Co Gmbh | Radial tube centrifuge |
US3741400A (en) * | 1970-06-15 | 1973-06-26 | J Dick | Blood sample container |
US4707276A (en) * | 1981-04-15 | 1987-11-17 | Sherwood Medical Company | Fluid collection device with phase partitioning means |
FR2556096A1 (en) * | 1983-12-05 | 1985-06-07 | Sarstedt Kunststoff | DEVICE FOR INTERCALATING A SEPARATION GEL BETWEEN TWO PHASES PLACED IN A TUBE TEST |
DE4101952A1 (en) * | 1991-01-19 | 1992-07-23 | Ff Diagnostic Vertrieb Gmbh | Test tube and pipette for centrifuging liq. samples - has tube of reduced diameter at short distance above lower end which retains liq. contg. solid particles after centrifuging |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010014033A1 (en) * | 2008-07-31 | 2010-02-04 | Ge Healthcare Bio-Sciences Ab | Separation device |
US9097631B2 (en) | 2008-12-01 | 2015-08-04 | Baxter International Inc. | Apparatus and method for processing biological material |
US9176038B2 (en) | 2008-12-01 | 2015-11-03 | Baxalta Incorporated | Apparatus and method for processing biological material |
US9182328B2 (en) | 2008-12-01 | 2015-11-10 | Baxalta Incorporated | Apparatus and method for processing biological material |
US9423327B2 (en) | 2008-12-01 | 2016-08-23 | Baxalta GmbH | Apparatus and method for processing biological material |
US9199250B2 (en) | 2009-05-01 | 2015-12-01 | Trustees Of Boston University | Disposable separator/concentrator device and method of use |
CN110832061A (en) * | 2017-10-06 | 2020-02-21 | 史蒂芬.何 | Device and method for collecting and separating cells |
EP3692136A4 (en) * | 2017-10-06 | 2021-06-23 | Stephen Ho | An apparatus and method for collecting and isolating cells |
Also Published As
Publication number | Publication date |
---|---|
DE69503512T2 (en) | 1999-04-08 |
US5577513A (en) | 1996-11-26 |
DK0778794T3 (en) | 1999-04-19 |
NZ292754A (en) | 1999-01-28 |
AU680383B2 (en) | 1997-07-24 |
DE69503512D1 (en) | 1998-08-20 |
HK1013807A1 (en) | 1999-09-10 |
ES2121414T3 (en) | 1998-11-16 |
JPH10509580A (en) | 1998-09-22 |
EP0778794A1 (en) | 1997-06-18 |
ATE168288T1 (en) | 1998-08-15 |
AU3502395A (en) | 1996-03-22 |
EP0778794B1 (en) | 1998-07-15 |
CA2198606A1 (en) | 1996-03-07 |
CA2198606C (en) | 2000-10-17 |
JP3487604B2 (en) | 2004-01-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU680383B2 (en) | Centrifuge syringe apparatus and method | |
EP1509326B1 (en) | Method and apparatus for isolating platelets from blood | |
US9808568B2 (en) | Apparatus and method for separating and concentrating a component of a fluid | |
US7780860B2 (en) | Apparatus and method for separating and concentrating fluids containing multiple components | |
US5474687A (en) | Methods for enriching CD34+ human hematopoietic progenitor cells | |
EP2887977B1 (en) | Apparatus and method for separation and concentrating fluids containing multiple components | |
US7374678B2 (en) | Apparatus and method for separating and concentrating fluids containing multiple components | |
EP1940550A1 (en) | Cell separation method and apparatus | |
US11325118B1 (en) | Device, kit and methods for creating platelet rich plasma | |
US11759775B2 (en) | Device, kit and methods for creating platelet rich plasma | |
US20240075196A1 (en) | Apparatus and methods for extracellular vesicle enrichment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): KE MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 292754 Country of ref document: NZ |
|
ENP | Entry into the national phase |
Ref document number: 2198606 Country of ref document: CA Ref country code: CA Ref document number: 2198606 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1995931683 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1995931683 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWG | Wipo information: grant in national office |
Ref document number: 1995931683 Country of ref document: EP |