WO1996004881A1 - Device for ensuring that medication is taken at the correct time - Google Patents
Device for ensuring that medication is taken at the correct time Download PDFInfo
- Publication number
- WO1996004881A1 WO1996004881A1 PCT/AT1995/000159 AT9500159W WO9604881A1 WO 1996004881 A1 WO1996004881 A1 WO 1996004881A1 AT 9500159 W AT9500159 W AT 9500159W WO 9604881 A1 WO9604881 A1 WO 9604881A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blister pack
- medication
- housing
- conductor tracks
- electronic circuit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
- A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
- A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
Definitions
- the invention relates to a device for taking medication on time in portioned particle form, e.g. Pills, dragees or capsules, with a housing which encloses a memory formed by a blister pack with a plurality of cavities for receiving the medication to be taken and has an electronic circuit with a counter and an adjustable signal transmitter for triggering alarm signals at the desired time of taking the medication , wherein the memory is covered below by a separate cover part, which is penetrated by the medication when the medicament particle is pressed out of the blister pack, for which purpose the housing has openings corresponding to the cavities of the blister pack, and each cavity of the blister pack has a conductor track crossing this cavity is assigned, which is interrupted when the respective medicament particle is pressed through, and all of these conductor tracks are connected to the electronic circuit which evaluates the interruption of the conductor tracks.
- a separate cover part which is penetrated by the medication when the medicament particle is pressed out of the blister pack
- the housing has openings corresponding to the cavities of the blister pack, and each cavity of the blister
- a further device is known (AT-PS 393.956) to support the timely taking of medication, but in which the medicament particles have to be inserted individually into openings in a circular disk before the device is ready for operation. This is often a hindrance to rapid, problem-free use, since numerous medications are packed in special packaging, in particular so-called blister packaging, for reasons of hygiene and to avoid confusion where possible (Blister packs) are packed.
- Devices of the type described at the outset are also known (DE-A 3,504,431 or DE-A 3,530,356), in which the removal of the medication from a blister pack is evaluated by an electronic circuit.
- a film separate from the blister pack is provided, which carries conductor tracks that run below the medication to be pushed through from the blister pack, so that each time a medicament is removed, a conductor track section is severed. Resistor sections are connected in parallel with the conductor tracks in order to evaluate the withdrawals from the blister pack or the interruptions in the conductor tracks caused thereby.
- the evaluation is therefore carried out by measuring resistance, which has disadvantages in battery-operated devices due to the high current draw.
- the use of a separate film is disadvantageous because it not only means an increased outlay, but also makes it more difficult to push the medication out of the blister pack due to its additional resistance.
- the invention now has for its object to improve a device of the type described above so that the disadvantages mentioned are avoided and the device is reliable and space-saving suitable for the use of medication packed in blister packs, in particular a reliable detection of the medication withdrawal from the Blist packs are made and there is also the possibility to save the medication if it is important.
- the invention solves this problem in that the conductor tracks are applied as a conductive mask directly on the underside of the Bliste ⁇ ackung and that on the cover part below each conductor track an adjacent contact is arranged, which is connected to the electronic circuit, which for each interruption of a conductor track triggers a count signal. In this way it is possible to add original, packaged medication in particle form use and remove in a controlled manner.
- the housing surrounding the blister pack protects the blister pack against injuries and thus against the unintentional loss of medicament particles. Since the dimensions of the blister packs for the individual medications are generally of different sizes, it is possible to bind the device to a special preparation, which forms a safeguard against medication exchange. A precise removal check is possible because the electronic circuit only responds to the count when a medication has actually been pressed out of the blister pack and the associated conductor path has thus been interrupted. This provides the basis for precise compliance research.
- the conductive mask applied to the underside of the blister pack ensures that the conductor runs exactly at the point at which this is most favorable for the severing when the medication is pushed through from the blister pack. It is therefore a correct assignment of the conductor tracks to the cavities of the Bliste ⁇ ackung and thus a safe function is guaranteed.
- the conductive mask can be glued to the blister pack, however, within the scope of the invention, a particularly preferred embodiment consists of evaporating the conductor tracks as a metal oxide layer on the underside of the blister pack. This enables automatic production, which poses no problems when packaging the medication.
- the cover part below the conductor track not only carries the mating contacts, which together with the conductor tracks form the circuits assigned to the individual medications after the blister pack has been introduced into the housing, but this cover part also forms an abutment when the medication in question is pushed out of the blister pack, since this is the case Drug must pass through the cover.
- This ensures in a simple manner that the blister pack tears open when the medication is pressed through, where this is desired, i.e. where an interruption of the conductor track in question occurs safely.
- a preferred further development is that the
- Contacts are arranged on a circuit board which is arranged in the housing and which lies on the underside of the blister pack and forms the cover part and which has openings corresponding to the cavities of the blister pack.
- the sensing contacts are of course to be arranged outside the push-through points of the blister pack.
- the blister pack and preferably also the circuit board can be inserted into a guide of the housing.
- This insertion of the blister pack can be used to their conductive mask to activate the device, for example with an additional contact point, which is closed by the conductor tracks in the completely inserted state of the blister pack.
- the sliding guide is countersunk at the end of the insert.
- the sliding guide already prevents the blister pack from falling out of the housing, but it is expedient to additionally provide sliding covers which can be pushed onto the housing and cover the blister pack.
- This sliding cover expediently has at least one web facing the blister pack, which, when the sliding cover is in the closed state, presses the blister pack against the circuit board and thus ensures flawless contact.
- the electronic circuit has a memory for storing the time at which the medicament particles are removed.
- This memory is expediently connected to an interface via which the information contained in the memory can be queried at any time.
- FIG. 1 shows the device in an axonometric view, partially cut away.
- Fig.2 is a section along the line II-ll of Fig.1.
- 3 shows the individual components of the device in the disassembled state.
- 4 shows a block diagram of the essential components of the electronic circuit.
- 5 shows a schematic contact diagram and
- FIG. 6 shows potential states of different circuit components.
- the device has a housing 1 made of insulating material, advantageously plastic, which is formed by an elongated plate. Sliding guides 2 run in the longitudinal direction of the plate, into which a conventional blister pack 3 and a cover part 4 located underneath can be inserted.
- the cover part 4 is designed as a circuit board formed by a plastic plate.
- the blister pack 3 has, in a known manner, a plurality of cavities 5, eight in the exemplary embodiment shown, in which medications 6 in particle form are sealed off.
- the blister pack 3 which consists of an insulating carrier material, usually drug-compatible plastic, carries a mask 7, which forms electrically conductive conductor tracks 8 (FIG. 3).
- These guide tracks are expediently vapor-deposited on the underside of the blister pack 3 as a metal oxide layer.
- These conductor tracks are arranged in such a way that a conductor track is always interrupted when a medication 6 is blown out of the blister pack 3 to tear it at the bottom. This line interruption is triggered by an electronic circuit 9 for counting the number of blister packs 3 removed drug particles evaluated, which will be described in more detail later.
- the circuit board which forms the cover part 4 for the blister pack 3 downwards, is provided with the cavities 5 of the openings 10 which are assigned to the position and are so large that that the respective drug can be pushed through without any problems.
- Analogous openings 11 are located in the correct position in the bottom 12 of the housing 1.
- On the insertion side of the sliding guides 2, these and the bottom 12 are provided with countersinks 13, 13 'in order to facilitate the insertion of the blister pack 3.
- the housing 1 has a compartment, not shown, for receiving batteries used for power supply, which compartment is accommodated in a reinforced housing part 14 and can be closed by a cover 15 (FIG. 3).
- a sliding cover 16 can be provided so that it can be pushed onto the housing 1 when the device is not in use.
- the housing 1 covers the blister pack 3 with its sliding cover 16 and thereby prevents unintentional pushing through of medication.
- the sliding cover 16 may have a web 17 inside (FIG. 3) which presses on the middle part of the blister pack 3 from above and thus presses the conductor tracks 8 against the cover part 4, in order to improve the contact.
- the housing part 14 forms a stop for pushing on the sliding cover 16 (FIG. 3).
- the circuit board forming the cover part 4 carries all the parts which are necessary for the electrical function of the device. These parts are the individual cavities 5 of the blister pack 3, contacts 18 which cooperate with the conductor tracks 8 of the mask 7 of the blister pack 3. In order to ensure reliable contacting, the guide tracks 8 are provided with widenings 19 (FIG. 3) at the locations of the contacts 18. Furthermore, a scan contact 20 and a plus contact 21 are provided on the board. It also carries a keyboard 22 for setting the operating data, in particular the desired alarm times for taking medication in a timely manner, a quartz crystal 23 (FIG.
- a buzzer 24 expediently a piezo buzzer for emitting the alarm signal
- a display 25 on which the time of day or set data can be read
- a serial interface 26 which is expediently arranged on the underside of the circuit board 4 and via which a connection to further electronic devices is possible.
- the circuit board 4 carries a chip 27 with corresponding adaptation electronics, to which chip 27 all the contacts and devices mentioned are connected.
- the chip 27 also contains a memory for storing the times at which the individual medications 6 were removed from the blister pack 3.
- Key contacts 28 (FIG. 5) on circuit board 4 are assigned to keyboard 22.
- FIGS. 1 and 5 the lines 29, via which the contacts 18 or their widenings 19 and the contacts 20, 21 are connected to the chip 27, are only shown in broken lines. If a blister pack 3 is inserted into the device, it is above the middle
- Main web 30 (FIG. 3) of mask 7, plus contact 21 is connected to scan contact 20 of circuit board 4. This not only informs the microcomputer contained in the chip 27 that the blister pack 3 has been inserted, but also applies plus potential to the contacts 18 of the circuit board 4 formed by scanning pins. If a medication 6 is now pushed down through the openings 10, 11, an interruption of the conductor tracks 8 occurs at the relevant point, which is evaluated by the electronics in the chip 27. As a result, the content of the blister pack 3 can be determined at any time.
- Figures 1 to 3 and 5 show an application to blister packs 3 with eight drugs.
- the electronics shown in Fig. 4 has fourteen contacts 18, which are designated P1 to P14 there. Of course, there may be more or fewer scan pins. However, if one needed more than fourteen scanning contacts, a decimal / dual decoder would have to be used, which can decode larger numbers of numbers and introduce them into an 8-bit system. This would theoretically be able to record 254 drugs. However, since most blister packs contain between eight and fourteen medications, the arrangement with BCD numbers is sufficient.
- FIG. 6 shows the potential states of individual circuit points designated 32 to 48 of the circuit according to FIG.
- the R / C combination after the buffer stage causes a certain delay in the switch-on process. Only when the capacitor 49 has charged to its maximum value does the downstream Schmitt trigger reach its threshold voltage and put a high on the input 34 of the AND gate 50. This delay ensures that stable information is already present at the input of the 4-fold OR gate 51 when the AND condition for setting the downstream RS flop 52 occurs at node 34.
- One of the two monoflops 53, 54 then outputs a positive pulse at its output 40 or 41 to the input of the subsequent OR gate 55. If the decoder 33 has switched through and at least one positive signal is present at its BCD output, the 4-fold OR gate 51 outputs a high signal at its output 33. However, as long as the delay caused by the R / C combination is effective, the subsequent AND condition for setting the RS flop 52 is not met. Since there is a 0-1 change or a 1/0 change with each change of value on track A, depending on the parity, one of the two monoflops 53, 54 is triggered to trigger.
- the initialization process is triggered by setting the RS flops 52 when a low / high change takes place at its input 35. With the help of the negation at the reset input (node 36), the RS flop 52 is set on a rising edge (AND condition fulfilled) and reset on a falling edge. The set RS flop 52 emits a high signal at its output Q (node 37). The subsequent differentiating element 55 reacts to this with a low edge at the output (circuit point 39) of the subsequent AND element, for which part of the AND condition is fulfilled by the high signal in circuit point 37. Counting pulses are therefore only permitted if a non-empty blister pack 3 has been entered into the device and a certain delay time has also expired.
- the event 1 (start) signal occurring at node 39 sets the computer in chip 27 to a new cycle by applying the signal occurring at node 39 to an interrupt line.
- the device is now fully functional. With the normal function of the device, there is one each time it is removed
- Medicament a signal at one of the contact points 18 as a result of an interruption in the associated conductor track 8. This has the effect that there is a change in parity on track A of the BCD scan output. This fact is used for counting purposes. If the potential changes from low to high, one of the two monoflops 53, 54 is set, which emits a positive pulse for a certain time. If the potential changes in the opposite direction, then each other monoflop with the preceding negation becomes active. A positive pulse can therefore reach the input of the OR gate 56, either from the monoflop 53 or from the monoflop 54. If this occurs, a medication withdrawal process is present, but this is only registered when the subsequent AND gate 57 is switched through. This is only the case if the RS flop 52 is set.
- the counting pulses trigger an interrupt on the event 2 (count) line via the edge detector (differentiating element) 58 and the subsequent AND element 59.
- the components 53, 54 and 56 to 59 thus form a counter for counting the withdrawals from the blister pack 3.
- the target times of taking the medication that can be input on the keyboard 22 activate the buzzer 24 in a known manner and, if appropriate, also an optical signal at the time of taking the drug that is entered.
- the circuits required for this in the chip 27 are known and therefore do not need to be described in more detail.
- the serial interface 26 can be operated with only 3 contacts. These include a common ground, a request line and a transmission line, which transmits the data to a receiver connected to the interface 26, which also
- Synchronization tasks and level adjustments can take over according to RS 232 standard.
- the request event has the highest priority in the system. All of the electronics shown in FIG. 4, with the exception of switch 31, are expediently located in chip 27 (FIG. 3).
- the board 4 is expediently inserted and fixed in the housing 1 during assembly of the device in order to prevent the board 4 from being pulled out and possibly being damaged when an empty blister pack 3 is removed.
- the circuit board 4 is expediently pushed into the sliding guides 2 from the other end face of the housing 1 than the blister pack 3.
- the housing part 14 is divided into two, the lower part can form the cover 15.
- the upper part which can be separated from the housing 1, is placed on the circuit board 4 from above after the circuit board 4 has been pushed in, thereby forming a simple means of preventing the circuit board 4 from being pulled out so that the circuit board 22 with its keyboard 22 through corresponding openings 61 in the upper one Part 14 'of the housing part 14 ( Figure 3) passes through, so that the circuit board 4 is held in the housing 1.
- the housing part 14 is suitably held on the rest of the housing 1, e.g. by means of pins provided on the upper side of the sliding guides 2, into which corresponding recesses in the housing part 14 'engage.
- the housing 1 with its slide-on sliding cover 16 not only completely covers the blister pack, but also forms, with the central web 17, the function of pressing the conductor tracks of the blister pack against the contacts 18, 20, 21. This gives the device increased operational safety.
- the sliding cover 16 expediently also encloses the housing 1 on its bottom side, so that the blister pack cannot be damaged even from below. If a tablet or the like is to be removed, the sliding cover 16 does not need to be removed completely, but only to the extent that the opening 10 or 11 assigned to the tablet to be removed is completely released in the circuit board 4 or in the housing 1 not to hinder the passage of the tablet or the like.
- the openings 10 of the cover part 4 and the openings 11 of the housing 1 are expediently of the same size and shape, so that smooth channels result for the medicament particles to be pressed through from the blister pack 3 when the circuit board forming the cover part 4 is fully inserted into the housing 1.
- a circular shape of the openings 10, 11 is most expedient. Since the relative position of the Bliste ⁇ ackung 3, the cover 4 and the housing 1 is always secured, there can be no unwanted displacements of the Bliste ⁇ ackung 3, so that a perfect function always remain guaranteed, since the cavities of the Bliste ⁇ ackung 3 and the medication in them exactly come to rest on the openings 10, 11 in the insertion position of the blister pack 3.
- the device In order to make it easy for the patient to handle the device, the device has - as can be seen from the preceding explanations - an automatic start / stop. As a result, once the times of intake have been determined, complicated settings are no longer necessary. You only have to save the time and date once in order to set the desired alarm time or times.
- the device changes to the clock function.
- the battery voltage is immediately monitored. A drop in the battery voltage is indicated in a suitable manner. Since, in contrast to the known devices mentioned at the outset, no resistance measurement is carried out, the consumption of electrical power is very low in the device according to the invention, so that the batteries are used only slightly. Since, of course, the time counting also continues when the device is withdrawn, the time at which each individual medicament is withdrawn can be easily saved in a manner known per se.
- the chip 27 has an integrated memory. This is saved in Mode Event 2 (Count).
- the stored parameters can be read out at any time using the interface 26 and a suitable terminal (e.g. a PC).
- the capacity of the memory is expediently at least one month, in general a memory capacity of three months is sufficient.
- a suitable software forms a timer function for the times of removal.
- the display 25 switches from the time display to a visual display, e.g. "Push Pill”.
- the display 25 is only switched back to when the medication has been removed. This gives the user, in addition to the buzzer 24, an additional visual indication.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95926788A EP0794755A1 (en) | 1994-08-08 | 1995-08-07 | Device for ensuring that medication is taken at the correct time |
AU31050/95A AU3105095A (en) | 1994-08-08 | 1995-08-07 | Device for ensuring that medication is taken at the correct time |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0154394A AT401725B (en) | 1994-08-08 | 1994-08-08 | DEVICE FOR TAKING DRUGS ON TIME |
ATA1543/94 | 1994-08-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996004881A1 true WO1996004881A1 (en) | 1996-02-22 |
Family
ID=3515685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AT1995/000159 WO1996004881A1 (en) | 1994-08-08 | 1995-08-07 | Device for ensuring that medication is taken at the correct time |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0794755A1 (en) |
AT (1) | AT401725B (en) |
AU (1) | AU3105095A (en) |
WO (1) | WO1996004881A1 (en) |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003003970A1 (en) * | 2001-07-06 | 2003-01-16 | Dieter Hafner | Method for identifying blister packs of medicaments |
WO2003068138A1 (en) * | 2002-02-14 | 2003-08-21 | Udo Simon | Device for detecting the removal of a product from a packing system by an electronic unit |
WO2003068137A1 (en) * | 2002-02-14 | 2003-08-21 | Udo Simon | Blister pack system |
US7552824B2 (en) * | 2003-06-10 | 2009-06-30 | Meadwestvaco Corporation | Package with electronic circuitry |
ES2404138A1 (en) * | 2013-02-14 | 2013-05-24 | Flowlab Proyectos De Innovación, S.L. | Device and procedure of control of pharmacological adherence (Machine-translation by Google Translate, not legally binding) |
WO2014032077A1 (en) * | 2012-09-03 | 2014-03-06 | Manrex Pty Ltd. | Improvements relating to blister package compliance |
WO2018172204A1 (en) | 2017-03-23 | 2018-09-27 | Bayer Aktiengesellschaft | Supporting patients in the repeated taking of drugs |
WO2019141551A1 (en) | 2018-01-16 | 2019-07-25 | Bayer Aktiengesellschaft | Accompanying cardiac insufficiency patients |
WO2019145224A1 (en) | 2018-01-25 | 2019-08-01 | Bayer Business Services Gmbh | Monitoring of products |
EP3611109A1 (en) * | 2013-07-19 | 2020-02-19 | SONY Corporation | Signal processing device, seal-opening detection module, program, seal-opening detection method, and article-packaging material |
WO2020114841A1 (en) | 2018-12-03 | 2020-06-11 | Bayer Aktiengesellschaft | Tracking a collective of objects |
US10709642B2 (en) | 2016-06-18 | 2020-07-14 | Totusrx Inc. | Smart pack system for medicines |
WO2020234209A1 (en) | 2019-05-22 | 2020-11-26 | Bayer Business Services Gmbh | Monitoring of products |
US11291610B2 (en) | 2017-06-16 | 2022-04-05 | Koninklijke Philips N.V. | Harvesting energy during compression of a pill pack |
WO2023117560A1 (en) | 2021-12-20 | 2023-06-29 | Bayer Aktiengesellschaft | Tool for identifying measures against hypertension and for their monitoring |
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1994
- 1994-08-08 AT AT0154394A patent/AT401725B/en not_active IP Right Cessation
-
1995
- 1995-08-07 AU AU31050/95A patent/AU3105095A/en not_active Abandoned
- 1995-08-07 EP EP95926788A patent/EP0794755A1/en not_active Ceased
- 1995-08-07 WO PCT/AT1995/000159 patent/WO1996004881A1/en not_active Application Discontinuation
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Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003003970A1 (en) * | 2001-07-06 | 2003-01-16 | Dieter Hafner | Method for identifying blister packs of medicaments |
WO2003068138A1 (en) * | 2002-02-14 | 2003-08-21 | Udo Simon | Device for detecting the removal of a product from a packing system by an electronic unit |
WO2003068137A1 (en) * | 2002-02-14 | 2003-08-21 | Udo Simon | Blister pack system |
US7475784B2 (en) | 2002-02-14 | 2009-01-13 | Udo Simon | Device for detecting the removal of a product from a packing system by an electronic unit |
US7489594B2 (en) | 2002-02-14 | 2009-02-10 | Udo Simon | Blister pack system |
US7552824B2 (en) * | 2003-06-10 | 2009-06-30 | Meadwestvaco Corporation | Package with electronic circuitry |
WO2014032077A1 (en) * | 2012-09-03 | 2014-03-06 | Manrex Pty Ltd. | Improvements relating to blister package compliance |
ES2404138A1 (en) * | 2013-02-14 | 2013-05-24 | Flowlab Proyectos De Innovación, S.L. | Device and procedure of control of pharmacological adherence (Machine-translation by Google Translate, not legally binding) |
US11186420B2 (en) | 2013-07-19 | 2021-11-30 | Sony Corporation | Signal processing device, seal breakage detecting module, program, seal breakage detecting method, and article packing element |
EP3611109A1 (en) * | 2013-07-19 | 2020-02-19 | SONY Corporation | Signal processing device, seal-opening detection module, program, seal-opening detection method, and article-packaging material |
US10709642B2 (en) | 2016-06-18 | 2020-07-14 | Totusrx Inc. | Smart pack system for medicines |
WO2018172204A1 (en) | 2017-03-23 | 2018-09-27 | Bayer Aktiengesellschaft | Supporting patients in the repeated taking of drugs |
US11291610B2 (en) | 2017-06-16 | 2022-04-05 | Koninklijke Philips N.V. | Harvesting energy during compression of a pill pack |
WO2019141551A1 (en) | 2018-01-16 | 2019-07-25 | Bayer Aktiengesellschaft | Accompanying cardiac insufficiency patients |
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CN113168614A (en) * | 2018-12-03 | 2021-07-23 | 拜耳公司 | Aggregation of tracked objects |
WO2020114841A1 (en) | 2018-12-03 | 2020-06-11 | Bayer Aktiengesellschaft | Tracking a collective of objects |
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WO2023117560A1 (en) | 2021-12-20 | 2023-06-29 | Bayer Aktiengesellschaft | Tool for identifying measures against hypertension and for their monitoring |
Also Published As
Publication number | Publication date |
---|---|
EP0794755A1 (en) | 1997-09-17 |
AT401725B (en) | 1996-11-25 |
ATA154394A (en) | 1996-04-15 |
AU3105095A (en) | 1996-03-07 |
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