WO1996001628A1 - Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension - Google Patents
Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension Download PDFInfo
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- WO1996001628A1 WO1996001628A1 PCT/IB1995/000412 IB9500412W WO9601628A1 WO 1996001628 A1 WO1996001628 A1 WO 1996001628A1 IB 9500412 W IB9500412 W IB 9500412W WO 9601628 A1 WO9601628 A1 WO 9601628A1
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- WIPO (PCT)
- Prior art keywords
- microgranules
- moguisteine
- coatings
- coating
- dosage form
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Definitions
- This invention involves controlled-release pharmaceutical compositions in liquid dosage forms for the administration of moguisteine.
- Coughing may be pharmacologically relieved by either suppressing the neuronal coughing reflex or by reducing the amount or viscosity of fluids in the respiratory tract.
- Some antitussives of the first type termed "meconic agents, " act by centrally depressing coughing centers.
- Codeine one example of a meconic agent, is the most widely used antitussive, but has the disadvantage of potentially causing addiction. Thus, there is a need in the art for non-narcotic antitussives.
- Moguisteine is an antitussive that is as potent as codeine, dextromethorphan and zipripol, and 3 - 4 times more potent than (D,L)-dropropizine. Importantly, it causes no addiction, and is better tolerated in high doses than codeine or dextromethorphan as it induces sedation and a reduced lower tonus. Moguisteine is a racemic mixture of R(+) and S(-) enantiomers that have equivalent antitussive activity.
- moguisteine does not act via opioid receptors. Its site of action is peripheral, and it interacts with the so-called “rapidly adapting irritant receptors" (RARs) (Sampson, S.R., 2 et al., Adv.Exp.Med.Biol. 99:281-290, 1979).
- RARs rapid adapting irritant receptors
- Moguisteine has the characteristics of a prodrug. After oral or intravenous administration, only its active metabolite, (R,S)-2-[(methoxyphenoxy)methyl]-3-carboxy- acetyl]-l,3 thiazolidine acid, can be found in biological fluids in measurable quantities. This active metabolite, however, is not suitable for oral administration because it is absorbed at a rate five times slower than moguisteine.
- the moguisteine oral formulations known so far include tablets and packages for 200-mg doses and a conventional 2 % suspension.
- the daily dose ranges from 100 to 800 mg, with the lower dosages being administered to children.
- One limitation on the use of moguisteine is its short half-life after administration, which, in humans, is less than one hour. Prior to the present invention, this meant that frequent administration, i.e., at least three to four times a day, was necessary to maintain constant therapeutic blood levels (Castoldi D. et al., (1990), Pharmacol. Res. , 22:102). It is known that a requirement for multiple daily administrations adversely affects patient compliance.
- United States Patent No. 5,296,236 (hereinafter, the "'236 patent") describes controlled-release pharmaceutical compositions for liquid formulations, which comprise microgranules coated with several polymeric layers. In some of these compositions, a fraction of the active ingredient in the formulation is made available over time by release from the microgranules, whereas a fraction is present in the extragranular ingredients and is bioavailable immediately after administration.
- the compositions described in the '236 patent offer a suboptimal solution to particular problems raised by liquid administration of moguisteine.
- a first consideration is the very unpleasant taste of moguisteine. This makes the use of suspension formulations or solutions undesirable; thus, it is not possible to include immediately bioavailable extragranular moguisteine as in the '236 patent.
- the size of the microgranules after coating must be smaller than 500 ⁇ m. Granules with sizes larger than 500 ⁇ m cannot be easily suspended as they tend to rapidly sediment, causing a non-homogeneous distribution of the active ingredient on administration.
- Using microgranular particles smaller than 500 ⁇ m increases the surface area considerably, making it more difficult, as compared to tablets or pellets, to control release of the active ingredient and maintain it unchanged in time after reconstitution of the suspension. The difficulty is even greater when, as in the case of moguisteine, the lack of extragranular drug increases the diffusion gradient and speeds release of the drug from the granules to the surrounding milieu.
- a second consideration in designing an appropriate dosage form for moguisteine using the teachings of the '236 patent is the relatively low melting point of the molecule, i.e. , about 65°C (Drugs of the Future, (1991), 16:618).
- the problem arises because waxy lipophilic materials such as white beeswax, cetyl alcohol, stearyl alcohol, glyceryl monostearate and the like (the use of which as coating materials is taught in the '236 patent), are particularly advantageous for coating moguisteme-containing microgranules so as to effectively mask their bitter taste.
- compositions in a liquid suspension, capable of ensuring therapeutically active blood levels of moguisteine (or, more accurately, its biologically active metabolites) by one or two daily administrations.
- the composition is characterized by excellent palatability and good stability with time after reconstitution with water.
- It is a further object of the invention to provide a pharmaceutical composition comprising microgranules containing moguisteine that are coated with at lease three successive film layers that protect the moguisteine from dissolution in the oral cavity
- a controlled-release pharmaceutical dosage form suitable for the administration of moguisteine in a liquid suspension can be achieved using a multiplicity of microgranules containing moguisteine as an active ingredient, which are coated with a succession of at least three coating layers comprising alternating hydrophilic and lipophilic films and which are then formulated in a pharmaceutically acceptable vehicle.
- the microgranular core in addition to moguisteine, may contain at least one plasticizer, preferably polyethylene glycol, as well as other, optional, excipients, and have sizes from 50 to 500 ⁇ m and smooth surfaces suitable for coating with polymeric or waxy materials.
- the coatings prevent release of moguisteine in the oral cavity and ensure a subsequent predetermined release profile of moguisteine in distal parts of the gastrointestinal tract and maintenance of the release profile over time. At least one of the coatings should impart control release characteristics to the moguisteme-containing composition.
- the vehicle may comprise one or more of suspending, structuring, surfactant, sweetening, buffering, preserving and flavoring agents, as is within the skill in the art.
- the dosage form may be formulated as a liquid suspension in water (or in a mixture of water and water-miscible co-solvents) or as a dry powder to be reconstituted with water and/or other solvents at the time of use.
- microgranules containing moguisteine and polyethylene glycol in a proportion of 0.5-1 % by weight of the mixture receive one or two coatings comprising cellulose acetate phthalate alternating with one or two coatings comprising a waxy material such as, for example, mono-, di- and tri-glycerides of C 6 -C 36 fatty acids, carnauba wax, beeswax, candelilla wax, alcohols, fatty acids, or combinations of the foregoing.
- the waxy coating(s) is (are) applied in the melted state (i.e., without the use of solvents), by using heated compressed air as a spray medium under conditions that do not melt the microgranular core.
- the moguisteine formulations of the present invention not only exhibit controlled-release characteristics that reduce the number of administrations required to maintain consistent blood levels of moguisteine, but also display excellent palatability and stability upon reconstitution as a suspension. This is due to the fact that the active ingredient remains incorporated within the coated microgranulate immediately following ingestion, and thus passes easily and quickly through the upper digestive tract without being tasted.
- the present invention encompasses a method for symptomatic treatment of coughing, which comprises administering effective amounts for treating coughing of the dosage form described above.
- the present invention provides a method for preparing a palatable controlled-release pharmaceutical dosage form for the administration of moguisteine in a liquid suspension, which involves coating the moguisteme-containing microgranules with the waxy materials in their melted state, using heated compressed an ⁇ as a spray medium. The method is applicable to coating any microgranules containing any pharmaceutically active ingredient, but is particularly applicable to microgranules containing a low-melting active ingredient.
- Figure 1 is a graph illustrating the concentrations of moguisteine in the plasma of patients administered either a standard suspension, or the controlled-release formulation of the present invention.
- Figure 2 is a graph illustrating a simulation of the blood levels of moguisteine that would result after two administrations of a standard suspension of moguisteine or a single administration of the controlled-release moguisteine formulation of the present invention.
- compositions of the present invention include a multiplicity of coated microgranules, which comprise moguisteine with one or more optional plasticizers and excipients, to which at least three successive layers of polymeric coatings are applied, at least one of the coatings imparting controlled-release characteristics to formulations containing the coated microgranulates.
- Three sequential coatings preferably comprise (i) cellulose acetate phthalate and plasticizer(s); (ii) one or more waxes; and (iii) cellulose acetate phthalate, respectively.
- the coating (iii) can be identical to coating (i).)
- the coated microgranules are then formulated for use in liquid suspensions. These formulations preserve the release characteristics of the dosage forms carried in them.
- the present invention provides a controlled-release pharmaceutical composition that includes: coated microgranules for the controlled release of moguisteine having sizes ranging from 50 to 500 ⁇ m, preferably from 90 to 300 ⁇ m, which are capable of remaining easily in suspension in a liquid for extended times.
- the microgranules comprise: a) A core of moguisteine, with one or more optional plasticizers and excipients, granulated into microgranules having sizes smaller than 500 ⁇ m, uniform surfaces, substantially spherical shapes, apparent densities of about 500 to 600 g/1 and very low friabilities, which are obtained by wet-kneading micronised moguisteine (and plasticizers and excipients if present), using water or a mixture of water and other solvents. This results in microgranules with no controlled-release properties prior to coating, which have physical properties that ensure reproducible and uniform distribution of subsequent coating layers. b) A first coating having essentially hydrophilic characteristics, which isolates the microgranules.
- a second coating having lipophilic characteristics on top of the first coating d) A third coating having hydrophilic characteristics.
- a vehicle system for the above controlled-release forms comprising either a dry mixture of additives which can be combined with the microgranules for long-term drug storage, or an aqueous solution with optional additives in which the moguisteine-containing microgranules can be suspended and maintained in optimum release conditions for an extended period of time.
- additives are given below.
- Procedures for mixing may be as described in U.S. Patent No. 5,296,236, or as described in co-pending U.S. Patent Application Serial No. 08/188,193 (the "'193 application", now allowed).
- polyethylene glycol (available as Carbowax from BASF Corp., Parsippany, NJ) is added to the microgranulate mixture before kneading, in an amount from about 0.3 to about 1 % , preferably 0.6%, relative to the weight of the mixture, to promote an optimum spherical shape and surface smoothness of the microgranules to be coated.
- PEG is highly soluble in water (i.e., at concentrations higher than 10% W/V) and thus facilitates wetting of moguisteine, which is relatively insoluble in aqueous fluids.
- PEG was surprisingly found to promote the formation of microgranule spherical shapes even when present at concentrations lower than 1 % .
- any PEG preparation containing polymers of molecular weight from 200 to 8000 may be used, preferably from 5000 to 7000, and most preferably PEG 6000 (CARBOWAX ® 6000).
- the moguisteme-containing microgranular cores may also contain optional excipients, including fillers and binders, selected without limitation from those commonly used in wet mixing, such as lactose, dibasic calcium phosphate, microcrystalline cellulose, starch, talc, sugars, polyvinylpyrrolidone, gelatin, a copolymer of polyvinylpyrrolidone and vinyl acetate, and the like.
- the microgranules contain lactose as a filler (lactose content is in the range 10-50% by weight) and polyvinylpyrrolidone as a binder (PVP content is in the range 5-20% by weight).
- the mixing liquid used for wet-granulation for example in high-speed mixer-granulators, can be water; or a solvent that is miscible with water, such as, for example, ethyl alcohol or other alcohols used in the pharmaceutical industry; or mixtures of water and at least one other solvent thereof.
- the operating conditions for the kneading and granulation steps are those that result in a microgranulate with optimum physical characteristics that enable the deposition of an effective coating.
- the '193 application describes acceptable and preferred ranges for process parameters using a fast mixer and mill, e.g. , the relative proportion of mixing fluid added to the dry microgranulate mixture; the rate at which the fluid is sprayed; the spray pressure; the kneading time; and the independent mixer and mill speeds.
- the kneaded mixture is then dried to a residual humidity of 1-10%, preferably 5-8 % , and screened to select particles of the required size range.
- microgranulate is evaluated with respect to the following properties: particle size distribution, density (aerated, packed, and apparent), Carr index (compressibility), and angle of repose. Finally, as described below, the granulate is coated with films of different compositions.
- Coatings Coating the moguisteme-containing microgranulate in accordance with the present invention serves at least two purposes. First, the coatings prevent the release of moguisteine in the oral cavity, thereby masking the bitter taste of moguisteine and increasing the palatability of liquid formulations comprising moguisteine. Second, the coatings ensure a controlled-release profile of moguisteine delivery after it reaches the gastric and intestinal milieus. Coated moguisteme-containing microgranules should comprise a pH-resistant (i.e. , enteric) coating layer but it need not be the first one applied of the at least three coatings. Moguisteme-containing microgranules are thus coated with at least three alternating 9 hydrophilic and hydrophobic coating layers as described below.
- the last- applied coating should be hydrophilic to aid solvation and suspension.
- the preferred coating technique for all of the coating below is the fluid-bed technique in accordance with the Wuster technology (Jones, D., Drug Dev. Indus. Pharm. 20:3175-3206, 1994).
- Substances suitable for the first type of coating include without limitation hydrophilic substances such as, for example, derivatives of cellulose (such as cellulose acetate phthalate, hydroxypropylmethyl cellulose phthalate, ethyl cellulose, carboxyl methyl cellulose acetate, and the like) and acrylic polymers (such as co-polymers of esters of methacrylic and acrylic acid, methyl methacrylate, and the like).
- cellulose acetate phthalate or hydroxypropylmethylcellulose phthalate are used.
- These polymers may be optionally mixed with plasticizers such as diethyl phthalate, dibutyl sebacate, vegetable oils and the like that are well-known in controlled-release formulations.
- Substances suitable for the second type of coating layer include without limitation fatty substances such as mono-, di- and tri-glycerides of C 6 -C 36 fatty acids, carnauba wax, beeswax, candelilla wax, alcohols, fatty acids and combination thereof. These coatings can be applied with the help of chlorinated solvents. Preferably, however, the waxes are applied in the melted state, with no use of solvents. Since moguisteine has a low melting point (65 °C), it is important to use conditions that allow coating without melting the moguisteine in the core.
- the constituents of the vehicle can include without limitation: suspending or structuring agents such as cellulose esters, microciystalline cellulose, alginic acid derivatives, and polyvinylpyrrolidone derivatives; - surfactants (preferably anionic or nonionic) such as Span 20, Span
- sugars such as sucrose, sorbitol, xylitol, dextrose and the like
- buffering substances such as citric acid and sodium citrate, glycine and hydrochloric acid, sodium phosphate, and potassium phosphate
- - preservatives and bacteriostatic agents such as esters of p-hydroxybenzoic acid
- various flavorings and sweeteners commonly used in pharmaceuticals are commonly used in pharmaceuticals.
- the ready-to-use formulation also comprises water, or mixtures of water and pharmaceutically acceptable water-miscible co-solvents known in the art such as glycols, alcohols and glycerol.
- the compositions of the present invention lend themselves to different presentation forms, including, for instance, (i) multi-dose granular formulations wherein dose flexibility is obtained by measuring different amounts of granules to be re-suspended when needed; (ii) accurately-measurable single-dose formulations in the form of sachets; (iii) bottles with reservoir caps for offhand reconstitution; and other forms known to the art.
- the present invention also encompasses formulations comprising concentrated drops (e.g. , drops containing 10% w/v moguisteine which works out to about 5 mg of active ingredient per drop) in which the granules containing moguisteine are suspended.
- the pharmaceutical formulation of the present invention are intended to deliver effective amounts of moguisteine in one or two daily administrations.
- An "effective amount" of moguisteine is one that provides relief from coughing in a patient. It will be understood that an effective amount can be delivered at a given time by ingestion of a single dose or a plurality of doses.
- a daily dose of moguisteine effective in preventing and/or treating coughing is from about 5 to about 15 mg/kg weight of the patient. The average dose is 9 mg/kg.
- administration of an antitussive effective amount of moguisteine may involve once or twice daily administration of about 2 to about 30 ml and preferably 10 ml of a final formulation (prepared as described in Example 8A below) containing 30 mg/ml moguisteine.
- the benefits of the present invention include a considerable improvement in patient compliance, based on both a reduction in the number of daily doses and good palatabihty. Additional benefits are anticipated in pediatric practice due to the ease of administration and swallowing. Furthermore, a better therapeutic response is likely to result, since, in a preferred embodiment, the formulation permits modulation of dosage as a function of need simply by measuring the required suspension volumes.
- a mixture made up of 79% (w/w) moguisteine, 10% (w/w) polyvinylpyrrolidone (PVP K30) and 10 % (w/w) 450-mesh lactose was mixed in a Diosna P25 mixer-granulator for 10 minutes.
- a 1 % (w/w) of PEG 6000 was added as an aqueous solution to the stirred mixture at a rate of 25 ml/min using a 0.8 mm nozzle at a pressure of 2 bars.
- the mixer speed was 175 rpm and the speed of the mill was 3000 rpm.
- the time required to add the solution was 20 minutes.
- the kneading and rounding step was performed by maintaining mixer and mill speeds at a constant rate for 15 minutes.
- the microgranulate so obtained was dried in an artificial- ventilation incubator and then sieved through a 225 -mesh/cm 2 screen until a microgranulate with a granule size distribution ranging from 90 to 300 ⁇ m, a spheroidal shape, a tapped density of 0.593 g/ml, and a real density of 1.36 g/ml was obtained.
- a mixture made up of 79.4% (w/w) moguisteine, 10% (w/w) 450-mesh lactose, 10% (w/w) PVP K30 and 0.6% (w/w) PEG 6000 was wetted with 500 ml of water, which was added at a rate of 25 ml/min over 15 minutes. PEG was added as a 5 % solution as in Example 1 above. The speed of the mixer was 175 rpm and that of the mill 3000 rpm. The microgranulate obtained after drying had 4% residual moisture, an untapped density of 0.548 g/ml, a tapped density of 0.669 g/ml, a Carr index of 18.08% and an actual density of 1.38 g/ml.
- a mixture of waxes was prepared having the following weight per-cent composition:
- Example 4 The same ingredients and procedures described in Example 4 for depositing the first coating layer were used for the final coating layer.
- Sedimentation F which is the ratio between the height of the sediment the height of a suspension that had been stirred allowed to st for 3 days
- pH 4.3
- a single-dose kinetic study using the formulation of the present invention was conducted to evaluate moguisteine bioavailability.
- Six healthy volunteers received a single 10 ml dose of a controlled-release liquid formulation (equivalent to 300 mg of moguisteine) prepared as described in Example 8. Blood samples were taken at different times, and the moguisteine plasma concentration (evaluated as an acid) was determined by an HPLC method.
- the volunteers were administered a dose of a conventional 2 % suspension equivalent to 200 mg of moguisteine.
- Table 4 compares the main pharmacokinetic parameters obtained from the two formulations.
- AUCo. 0 ,, (Area under the curve) the total area of the time-concentration profile and represents a measure of the bioavailability.
- suspension prepared according to the present invention exhibits the properties of a controlled release formulation with excellent bioavailability.
- Figure 1 shows these results after normalization of moguisteine blood levels for the difference between the initial moguisteine dose in the controlled-release and conventional formulations.
- the graph shows dose concentration values (L 1 ) on the ordinates and time on the abscissas.
- the data indicate that the administration of moguisteine according to the present invention permits the initial peak effect to be avoided and the number of daily dosages to be reduced, while ensuring satisfactory therapeutic blood levels of moguisteine over an extended time.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ199750A CZ287967B6 (en) | 1994-07-07 | 1995-05-29 | Pharmaceutical dosage form with controlled release, process of its preparation and preparation for treating cough |
JP8504206A JPH10502629A (en) | 1994-07-07 | 1995-05-29 | Pharmaceutical compositions for controlled release of moguisteine in suspension |
EP95918125A EP0769948A1 (en) | 1994-07-07 | 1995-05-29 | Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension |
AU24176/95A AU2417695A (en) | 1994-07-07 | 1995-05-29 | Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension |
BR9510302A BR9510302A (en) | 1994-07-07 | 1995-05-29 | Controlled-release pharmaceutical dosage form Method for symptomatic treatment of cough Method for preparing a controlled-release pharmaceutical dosage form composition for use in the symptomatic treatment of cough and application of a controlled-release moguistein dosage form |
KR1019970700062A KR970704437A (en) | 1994-07-07 | 1995-05-29 | Wherein the release is controlled, the pharmaceutical composition comprising a suspension of a statin pharmaceutical composition (PHARMACEUTICAL COMPOSITION FOR THE CONTROLLED RELEASE OF MOGUISTEINE IN A LIQUID SUSPENSION |
MX9700223A MX9700223A (en) | 1994-07-07 | 1995-05-29 | Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI94A001410 | 1994-07-07 | ||
ITMI941410A IT1270594B (en) | 1994-07-07 | 1994-07-07 | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN |
Publications (1)
Publication Number | Publication Date |
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WO1996001628A1 true WO1996001628A1 (en) | 1996-01-25 |
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ID=11369231
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IB1995/000412 WO1996001628A1 (en) | 1994-07-07 | 1995-05-29 | Pharmaceutical composition for the controlled release of moguisteine in a liquid suspension |
Country Status (12)
Country | Link |
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US (1) | US5674533A (en) |
EP (1) | EP0769948A1 (en) |
JP (1) | JPH10502629A (en) |
KR (1) | KR970704437A (en) |
AU (1) | AU2417695A (en) |
BR (1) | BR9510302A (en) |
CA (1) | CA2194374A1 (en) |
CZ (1) | CZ287967B6 (en) |
HU (1) | HUT76832A (en) |
IT (1) | IT1270594B (en) |
MX (1) | MX9700223A (en) |
WO (1) | WO1996001628A1 (en) |
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US6342496B1 (en) | 1999-03-01 | 2002-01-29 | Sepracor Inc. | Bupropion metabolites and methods of use |
US6337328B1 (en) | 1999-03-01 | 2002-01-08 | Sepracor, Inc. | Bupropion metabolites and methods of use |
US6353005B1 (en) | 1999-03-02 | 2002-03-05 | Sepracor, Inc. | Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist |
US6362202B1 (en) | 1999-03-02 | 2002-03-26 | Sepracor Inc. | Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists |
US6410052B1 (en) | 1999-03-30 | 2002-06-25 | Purdue Research Foundation | Tea catechins in sustained release formulations as cancer specific proliferation inhibitors |
US6428818B1 (en) | 1999-03-30 | 2002-08-06 | Purdue Research Foundation | Tea catechin formulations and processes for making same |
CZ20013607A3 (en) | 1999-04-06 | 2002-06-12 | Sepracor Inc. | Pharmaceutical preparation |
US6951873B1 (en) | 1999-04-27 | 2005-10-04 | Pfizer Inc. | Methods for treating age-related behavioral disorders in companion animals |
DE60026146T2 (en) | 1999-09-03 | 2006-08-17 | Apbi Holdings, Llc | Use of dapoxetine, A selective serotonin uptake inhibitor, for the treatment of sexual dysfunction |
ATE364689T1 (en) | 1999-11-18 | 2007-07-15 | Dendreon Corp | NUCLEIC ACIDS WHICH CODE FOR ENDOTHELIASES, ENDOTHELIASES, AND THEIR USE |
US7182953B2 (en) | 1999-12-15 | 2007-02-27 | Celgene Corporation | Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders |
KR100574213B1 (en) * | 2000-01-27 | 2006-04-27 | 다나베 세이야꾸 가부시키가이샤 | Sustained-release preparation and process for producing the same |
US7700341B2 (en) * | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
KR20030003708A (en) * | 2000-03-31 | 2003-01-10 | 셀진 코포레이션 | Inhibition of cyclooxygenase-2 activity |
US7259152B2 (en) | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
US20070208087A1 (en) | 2001-11-02 | 2007-09-06 | Sanders Virginia J | Compounds, compositions and methods for the treatment of inflammatory diseases |
DE60130799T2 (en) * | 2000-11-30 | 2008-07-17 | Children's Medical Center Corp., Boston | SYNTHESIS OF 4-AMINOTHALIDOMIDE ENANTIOMERS |
US20030167524A1 (en) * | 2000-12-19 | 2003-09-04 | Rooijen Gijs Van | Methods for the production of multimeric protein complexes, and related compositions |
WO2002064543A2 (en) * | 2001-02-12 | 2002-08-22 | Wyeth | Novel succinate salt of o-desmethyl-venlafaxine |
FR2821747B1 (en) * | 2001-03-09 | 2004-07-02 | Ethypharm Lab Prod Ethiques | SUSPENSION OF TELITHROMYCIN WITH A MASK TASTE |
FR2821745B1 (en) * | 2001-03-09 | 2004-07-02 | Ethypharm Lab Prod Ethiques | GRANULES AND GRANULES COATED WITH MASK TASTE |
AU2002305052A1 (en) | 2001-03-13 | 2002-09-24 | Corvas International, Inc. | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon |
JP2004535166A (en) | 2001-03-22 | 2004-11-25 | デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー | Nucleic acid molecule encoding serine protease CVSP14, encoded polypeptide and methods based thereon |
EP1379637A4 (en) | 2001-03-27 | 2005-04-06 | Dendreon Corp | Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon |
JP2005506832A (en) | 2001-05-14 | 2005-03-10 | デンドレオン・サンディエゴ・リミテッド・ライアビリティ・カンパニー | Nucleic acid molecule encoding transmembrane serine protease 10, encoded polypeptide and method based thereon |
AU2002346065A1 (en) * | 2001-07-05 | 2003-01-21 | Marantech Holding, Llc | Methods of using electron active compounds for managing conditions afflicting mammals |
US20030087963A1 (en) | 2001-09-13 | 2003-05-08 | Senanayake Chris H. | Methods of preparing and using 2-hydroxy derivatives of sibutramine and its metabolites |
US20030134794A1 (en) * | 2001-11-20 | 2003-07-17 | Madison Edwin L. | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
CA2469306A1 (en) | 2001-12-05 | 2003-06-19 | Baylor College Of Medicine | Methods and compositions for control of bone formation via modulation of sympathetic tone |
US20040009953A1 (en) * | 2002-01-10 | 2004-01-15 | Comper Wayne D. | Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof |
US20030181416A1 (en) * | 2002-01-10 | 2003-09-25 | Comper Wayne D. | Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof |
AU2003212882A1 (en) | 2002-02-01 | 2003-09-02 | Euro-Celtique S.A. | 2 - piperazine - pyridines useful for treating pain |
US7446107B2 (en) * | 2002-02-15 | 2008-11-04 | Transform Pharmaceuticals, Inc. | Crystalline forms of conazoles and methods of making and using the same |
US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
CA2477923C (en) | 2002-03-01 | 2021-02-23 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
US7205413B2 (en) * | 2002-05-03 | 2007-04-17 | Transform Pharmaceuticals, Inc. | Solvates and polymorphs of ritonavir and methods of making and using the same |
US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
US20100129363A1 (en) * | 2002-05-17 | 2010-05-27 | Zeldis Jerome B | Methods and compositions using pde4 inhibitors for the treatment and management of cancers |
USRE48890E1 (en) | 2002-05-17 | 2022-01-11 | Celgene Corporation | Methods for treating multiple myeloma with 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione after stem cell transplantation |
CA2486141A1 (en) | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
NZ549175A (en) | 2002-05-17 | 2007-12-21 | Celgene Corp | Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases |
US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
US6995168B2 (en) | 2002-05-31 | 2006-02-07 | Euro-Celtique S.A. | Triazaspiro compounds useful for treating or preventing pain |
PT1511710E (en) | 2002-05-31 | 2014-02-26 | Proteotech Inc | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer s disease, type 2 diabetes, and parkinson s disease |
AU2003243354A1 (en) * | 2002-05-31 | 2003-12-19 | Transform Pharmaceuticals, Inc. | Novel conazole crystalline forms and related processes, pharmaceutical compositions and methods |
US8829198B2 (en) | 2007-10-31 | 2014-09-09 | Proteotech Inc | Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies |
US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
MXPA05000232A (en) * | 2002-06-21 | 2005-06-17 | Transform Pharmaceuticals Inc | Pharmaceutical compositions with improved dissolution. |
WO2004009558A2 (en) | 2002-07-24 | 2004-01-29 | Ptc Therapeutics, Inc. | Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations |
WO2004015666A1 (en) * | 2002-07-29 | 2004-02-19 | Koninklijke Philips Electronics N.V. | Driving a plasma display panel |
CA2500118C (en) | 2002-09-25 | 2011-04-12 | Euro-Celtique S.A. | N-substituted hydromorphones and the use thereof |
EP1551386A4 (en) * | 2002-09-27 | 2009-03-25 | Bioenvision Inc | Methods and compositions for the treatment of lupus using clofarabine |
AU2003276988B2 (en) * | 2002-09-27 | 2009-11-05 | Bioenvision, Inc. | Methods and compositions for the treatment of autoimmune disorders using clofarabine |
US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
US7189740B2 (en) | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
ZA200503024B (en) * | 2002-10-15 | 2006-11-29 | Celgene Corp | Selective cytokine inhibitory drugs for treating myelodysplastic syndrome |
US8404717B2 (en) * | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes using lenalidomide |
EP1900369A1 (en) | 2002-10-15 | 2008-03-19 | Celgene Corporation | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes |
US20040087558A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain |
US20050203142A1 (en) * | 2002-10-24 | 2005-09-15 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain |
US7776907B2 (en) | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
CA2505003A1 (en) * | 2002-11-06 | 2004-05-27 | Celgene Corporation | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
KR100923173B1 (en) | 2002-11-06 | 2009-10-22 | 셀진 코포레이션 | Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases |
US7202259B2 (en) * | 2002-11-18 | 2007-04-10 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
CA2506232A1 (en) * | 2002-11-18 | 2004-06-03 | Celgene Corporation | Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
AU2003294312A1 (en) * | 2002-11-18 | 2004-07-09 | Celgene Corporation | Methods of usig and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
US6864251B2 (en) | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
EP2298874A1 (en) | 2002-12-16 | 2011-03-23 | Halozyme, Inc. | Human chondroitinase glycoprotein (CHASEGP), process for preparing the same, and pharmaceutical compositions comprising thereof |
US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
EP2339328A3 (en) | 2002-12-30 | 2011-07-13 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of celecoxib |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
AU2003272270A1 (en) | 2003-02-28 | 2004-09-28 | The Regents Of The University Of Michigan | Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
US20090123367A1 (en) * | 2003-03-05 | 2009-05-14 | Delfmems | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
EP2405015B1 (en) | 2003-03-05 | 2016-01-06 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
US20040214893A1 (en) * | 2003-04-11 | 2004-10-28 | Matthew Peterson | Gabapentin compositions |
SI3632902T1 (en) | 2003-04-11 | 2022-01-31 | Ptc Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease |
CA2525969A1 (en) * | 2003-05-16 | 2005-02-24 | Receptor Biologix, Inc. | Intron fusion proteins, and methods of identifying and using same |
JP2007502329A (en) * | 2003-05-23 | 2007-02-08 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | Sertraline composition |
US8916598B2 (en) | 2003-05-30 | 2014-12-23 | Proteotech Inc | Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies |
US20100331380A1 (en) * | 2009-06-29 | 2010-12-30 | Esposito Luke A | Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies |
US7438903B2 (en) * | 2003-06-06 | 2008-10-21 | Nbty, Inc. | Methods and compositions that enhance bioavailability of coenzyme-Q10 |
CN1319955C (en) * | 2003-06-10 | 2007-06-06 | 浙江海正药业股份有限公司 | Moguisteine crystallographic form |
AR044688A1 (en) * | 2003-06-12 | 2005-09-21 | Euro Celtique Sa | USEFUL THERAPEUTIC AGENTS FOR THE TREATMENT OF PAIN |
PL1641775T3 (en) * | 2003-07-03 | 2009-07-31 | Euro Celtique Sa | 2-pyridine alkyne derivatives useful for treating pain |
US20050009782A1 (en) * | 2003-07-09 | 2005-01-13 | Comper Wayne D. | Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof |
NZ545447A (en) | 2003-07-23 | 2010-03-26 | Synta Pharmaceuticals Corp | Compounds for inflammation and immune-related uses |
AU2004259358B2 (en) * | 2003-07-24 | 2008-03-20 | Euro-Celtique S.A. | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
EP1648878B9 (en) * | 2003-07-24 | 2011-03-16 | Euro-Celtique S.A. | Piperidine compounds and pharmaceutical compositions containing them |
EP1867644B1 (en) | 2003-07-24 | 2009-05-20 | Euro-Celtique S.A. | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
MXPA06001331A (en) * | 2003-08-01 | 2006-05-04 | Euro Celtique Sa | Therapeutic agents useful for treating pain. |
WO2005020954A2 (en) * | 2003-09-03 | 2005-03-10 | Agi Therapeutics Limited | Proton pump inhibitor formulations, and methods of preparing and using such formulations |
UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
PL1664016T3 (en) * | 2003-09-22 | 2009-04-30 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
CA2537010A1 (en) * | 2003-09-22 | 2005-04-07 | Euro-Celtique S.A. | Phenyl - carboxamide compounds useful for treating pain |
US7612096B2 (en) * | 2003-10-23 | 2009-11-03 | Celgene Corporation | Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline |
US20050113410A1 (en) * | 2003-11-03 | 2005-05-26 | Mark Tawa | Pharmaceutical salts of zafirlukast |
US20070208057A1 (en) * | 2003-11-06 | 2007-09-06 | Zeldis Jerome B | Methods And Compositions Using Thalidomide For The Treatment And Management Of Cancers And Other Diseases |
US7470435B2 (en) * | 2003-11-17 | 2008-12-30 | Andrx Pharmaceuticals, Llc | Extended release venlafaxine formulation |
AU2004293443A1 (en) | 2003-11-19 | 2005-06-09 | Signal Pharmaceuticals, Llc. | Indazole Compounds and methods of use thereof as protein kinase inhibitors |
EP2428516A1 (en) | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
KR100589357B1 (en) * | 2003-11-27 | 2006-06-14 | 삼성에스디아이 주식회사 | Plasma display panel which is suitable for spreading phosphors |
DE602004019576D1 (en) * | 2003-12-30 | 2009-04-02 | Euro Celtique Sa | FOR THE TREATMENT OF PAIN PIPERAZINE |
EP2292213A1 (en) | 2004-02-06 | 2011-03-09 | Cephalon, Inc. | Compositions comprising a polymorphic form of armodafinil |
US20060003001A1 (en) * | 2004-02-11 | 2006-01-05 | John Devane | Chronotherapeutic compositions and methods of their use |
EP1720540B1 (en) | 2004-02-18 | 2008-06-11 | GPC Biotech AG | Satraplatin for treating resistant or refractory tumors |
EP1737453A4 (en) | 2004-03-22 | 2008-11-26 | Celgene Corp | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of skin diseases or disorders |
WO2005092065A2 (en) * | 2004-03-25 | 2005-10-06 | Transform Pharmaceuticals, Inc. | Novel tricyclic compounds and related methods of treatment |
EA014429B1 (en) * | 2004-04-14 | 2010-12-30 | Селджин Корпорейшн | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of myelodysplastic syndromes |
JP2007532642A (en) * | 2004-04-14 | 2007-11-15 | セルジーン・コーポレーション | Use of selective cytokine inhibitors for the treatment and management of myelodysplastic syndromes and compositions containing the same |
KR20070007945A (en) * | 2004-04-23 | 2007-01-16 | 셀진 코포레이션 | Methods of using and compositions comprising pde4 modulators for the treatment and management of pulmonary hypertension |
US7351739B2 (en) * | 2004-04-30 | 2008-04-01 | Wellgen, Inc. | Bioactive compounds and methods of uses thereof |
KR20050105411A (en) * | 2004-05-01 | 2005-11-04 | 삼성에스디아이 주식회사 | Plasma display panel |
US7803366B2 (en) * | 2004-05-07 | 2010-09-28 | Nbty, Inc. | Methods and compositions that enhance bioavailability of coenzyme-Q10 |
AU2005245896A1 (en) * | 2004-05-14 | 2005-12-01 | Receptor Biologix, Inc. | Cell surface receptor isoforms and methods of identifying and using the same |
US7671093B2 (en) | 2004-05-28 | 2010-03-02 | Transform Pharmaceuticals, Inc. | Mixed co-crystals and pharmaceutical compositions comprising the same |
WO2005120584A2 (en) * | 2004-06-03 | 2005-12-22 | The Trustees Of Columbia University In The City Of New York | Radiolabeled arylsulfonyl compounds and uses thereof |
JP5017103B2 (en) * | 2004-06-17 | 2012-09-05 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | Pharmaceutical co-crystal composition and related methods of use |
US20080126195A1 (en) | 2004-07-22 | 2008-05-29 | Ritter Andrew J | Methods and Compositions for Treating Lactose Intolerance |
CA2573316A1 (en) * | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel fenofibrate formulations and related methods of treatment |
US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
NZ552389A (en) * | 2004-08-06 | 2009-05-31 | Transform Pharmaceuticals Inc | Statin pharmaceutical compositions and related methods of treatment |
NZ584773A (en) | 2004-09-17 | 2012-07-27 | Whitehead Biomedical Inst | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity |
JP2008513508A (en) * | 2004-09-21 | 2008-05-01 | シンタ ファーマシューティカルズ コーポレーション | Compounds used for inflammation and immunity related applications |
KR20070085454A (en) * | 2004-10-28 | 2007-08-27 | 셀진 코포레이션 | Methods and compositions using pde4 modulators for treatment and management of central nervous system injury |
WO2006053184A2 (en) * | 2004-11-10 | 2006-05-18 | The Trustees Of Columbia University In The City Of New York | Methods for treating or preventing a vascular disease |
CN103554042B (en) | 2004-11-18 | 2016-08-10 | Synta医药公司 | The triazole compounds of regulation HSP90 activity |
ES2401285T3 (en) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Drugs with lung as target |
ES2525567T3 (en) | 2004-12-17 | 2014-12-26 | Anadys Pharmaceuticals, Inc. | Compounds of 3H-oxazolo and 3H-thiazolo [4,5-d] pyrimidin-2-one 3,5-disubstituted and 3,5,7-trisubstituted and prodrugs thereof |
EP1674457B1 (en) | 2004-12-23 | 2009-06-03 | GPC Biotech AG | Derivatives of squaric acid with anti-proliferative activity |
US20060160783A1 (en) * | 2004-12-30 | 2006-07-20 | Transform Pharmaceuticals, Inc. | Novel omeprazole forms and related methods |
NZ556546A (en) * | 2005-01-07 | 2011-02-25 | Synta Pharmaceuticals Corp | Compounds for inflammation and immune-related uses |
ZA200707125B (en) | 2005-01-25 | 2008-11-26 | Synta Pharmaceuticals Corp | Compounds for inflammation and immune-related uses |
US8318210B2 (en) * | 2005-02-28 | 2012-11-27 | Neos Therapeutics, Lp | Compositions and methods of making sustained release liquid formulations |
US20060216355A1 (en) * | 2005-03-28 | 2006-09-28 | Donald Spector | Encapsulated pharmaceuticals in a medium having non-encapsulated flavoring agents |
CN101189249B (en) | 2005-04-01 | 2013-04-17 | 加利福尼亚大学董事会 | Phosphono-pent-2-en-1-yl nucleosides and analogs |
US20090156545A1 (en) * | 2005-04-01 | 2009-06-18 | Hostetler Karl Y | Substituted Phosphate Esters of Nucleoside Phosphonates |
JP2008539731A (en) | 2005-05-02 | 2008-11-20 | コールド スプリング ハーバー ラボラトリー | Compositions and methods for diagnosis and treatment of cancer |
WO2006119510A2 (en) * | 2005-05-04 | 2006-11-09 | Receptor Biologix, Inc. | Isoforms of receptor for advanced glycation end products (rage) and methods of identifying and using same |
US20070041944A1 (en) * | 2005-05-05 | 2007-02-22 | The Trustees Of Columbia University In The City Of New York | Treating tumors by ENH dislocation of ID proteins |
US20090170769A1 (en) * | 2005-05-13 | 2009-07-02 | Pei Jin | Cell surface receptor isoforms and methods of identifying and using the same |
US20060270707A1 (en) * | 2005-05-24 | 2006-11-30 | Zeldis Jerome B | Methods and compositions using 4-[(cyclopropanecarbonylamino)methyl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione for the treatment or prevention of cutaneous lupus |
US20100098640A1 (en) * | 2005-06-20 | 2010-04-22 | Cohen Seth M | Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation |
US20070054868A1 (en) * | 2005-06-20 | 2007-03-08 | The Trustees Of Columbia University In The City Of New York | Synergistic polyphenol compounds, compositions thereof, and uses thereof |
MX2008000249A (en) * | 2005-07-06 | 2008-03-18 | Sepracor Inc | Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders. |
JP2009505955A (en) | 2005-07-22 | 2009-02-12 | アムゲン インコーポレイティッド | Aniline sulfonamide derivatives and their use |
US20080058282A1 (en) | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
MX2008002765A (en) | 2005-08-31 | 2008-04-07 | Celgene Corp | Isoindole-imide compounds and compositions comprising and methods of using the same. |
US20070066512A1 (en) | 2005-09-12 | 2007-03-22 | Dominique Verhelle | Methods and compositions using immunomodulatory compounds for the treatment of disorders associated with low plasma leptin levels |
US20080138295A1 (en) * | 2005-09-12 | 2008-06-12 | Celgene Coporation | Bechet's disease using cyclopropyl-N-carboxamide |
US8492428B2 (en) * | 2005-09-20 | 2013-07-23 | Mayo Foundation For Medical Education And Research | Small-molecule botulinum toxin inhibitors |
US20070092553A1 (en) * | 2005-10-21 | 2007-04-26 | Pfab Lp | Compositions and methods of making rapidly dissolving lonically masked formulations |
EP2298770A1 (en) | 2005-11-03 | 2011-03-23 | ChemBridge Corporation | Heterocyclic compounds as TrkA modulators |
EP1959936A2 (en) | 2005-11-10 | 2008-08-27 | Circ Pharma Research and Development Limited | Once-daily administration of central nervous system drugs |
WO2007058776A2 (en) * | 2005-11-10 | 2007-05-24 | Receptor Biologix, Inc. | Hepatocyte growth factor intron fusion proteins |
CN101312964A (en) | 2005-11-21 | 2008-11-26 | 普渡制药公司 | 4-oxadiazolyl-piperidine compounds and use thereof |
US8138361B2 (en) * | 2005-12-28 | 2012-03-20 | The Trustees Of The University Of Pennsylvania | C-10 carbamates of taxanes |
US20070155791A1 (en) * | 2005-12-29 | 2007-07-05 | Zeldis Jerome B | Methods for treating cutaneous lupus using aminoisoindoline compounds |
CA2841386A1 (en) | 2005-12-30 | 2007-07-12 | Zensun (Shanghai) Science & Technology Limited | Extended release of neuregulin for improved cardiac function |
EP1983980A4 (en) * | 2006-01-25 | 2010-05-05 | Synta Pharmaceuticals Corp | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
WO2007087442A2 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
CA2640091A1 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
WO2007089904A2 (en) | 2006-01-31 | 2007-08-09 | Synta Pharmaceuticals Corp. | Pyridylphenyl compounds for inflammation and immune-related uses |
US7518017B2 (en) | 2006-02-17 | 2009-04-14 | Idexx Laboratories | Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds |
WO2007106468A2 (en) * | 2006-03-13 | 2007-09-20 | Encysive Pharmaceuticals, Inc. | Formulations of sitaxsentan sodium |
US20070232671A1 (en) * | 2006-03-13 | 2007-10-04 | Given Bruce D | Methods and compositions for treatment of diastolic heart failure |
AU2007225088B2 (en) | 2006-03-13 | 2012-09-13 | Kyorin Pharmaceutical Co., Ltd | Aminoquinolones as GSK-3 inhibitors |
EP2007373A4 (en) * | 2006-03-29 | 2012-12-19 | Foldrx Pharmaceuticals Inc | Inhibition of alpha-synuclein toxicity |
DE602007008237D1 (en) * | 2006-06-08 | 2010-09-16 | Amgen Inc | BENZAMID DERIVATIVES AND ASSOCIATED USES |
TW200808695A (en) * | 2006-06-08 | 2008-02-16 | Amgen Inc | Benzamide derivatives and uses related thereto |
US20100055093A1 (en) * | 2006-06-12 | 2010-03-04 | Receptor Biologix Inc. | Pan-cell surface receptor-specific therapeutics |
ATE496924T1 (en) | 2006-06-22 | 2011-02-15 | Anadys Pharmaceuticals Inc | PRODRUGS OF 5-AMINO-3-(3'-DEOXY-BETA-D-RIBOFURANOSYL)-THIAZOLÄ4,5-DÜPYRIMIDINE-2,7-DIONE |
US20080026061A1 (en) * | 2006-06-22 | 2008-01-31 | Reichwein John F | Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide |
CN101501039B (en) | 2006-06-22 | 2012-02-22 | 安那迪斯药品股份有限公司 | Pyrro[1,2-b]pyridazinone compounds |
JP4546578B2 (en) | 2006-07-05 | 2010-09-15 | カタリスト・バイオサイエンシーズ・インコーポレイテッド | Protease screening method and protease identified thereby |
WO2008008373A2 (en) | 2006-07-11 | 2008-01-17 | Arubor Corp | Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors |
DE602007012881D1 (en) | 2006-07-18 | 2011-04-14 | Anadys Pharmaceuticals Inc | Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen |
CL2007002218A1 (en) | 2006-08-03 | 2008-03-14 | Celgene Corp Soc Organizada Ba | USE OF 3- (4-AMINO-1-OXO-1,3-DIHIDRO-ISOINDOL-2-IL) -PIPERIDINE 2,6-DIONA FOR THE PREPARATION OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF LAYER CELL LYMPHOMA. |
WO2008029300A2 (en) * | 2006-08-04 | 2008-03-13 | Agi Therapeutics Research Limited | Methods for treating at least one condition having mt1 receptor, 5ht2b receptor, and l-type calcium channel activity |
US8063225B2 (en) | 2006-08-14 | 2011-11-22 | Chembridge Corporation | Tricyclic compound derivatives useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders |
US9114133B2 (en) | 2006-08-25 | 2015-08-25 | U.S. Dept. Of Veterans Affairs | Method of improving diastolic dysfunction |
NZ575061A (en) | 2006-08-30 | 2011-10-28 | Celgene Corp | 5-substituted isoindoline compounds |
US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
US7879846B2 (en) | 2006-09-21 | 2011-02-01 | Kyorin Pharmaceutical Co.., Ltd. | Serine hydrolase inhibitors |
US8779154B2 (en) | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
NZ575830A (en) | 2006-09-26 | 2012-03-30 | Celgene Corp | 5-substituted quinazolinone derivatives as antitumor agents |
EP2124556B1 (en) | 2006-10-09 | 2014-09-03 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
EP1914234A1 (en) * | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
DE602007013440D1 (en) | 2006-10-19 | 2011-05-05 | Auspex Pharmaceuticals Inc | SUBSTITUTED INDOLE |
EP2617423A1 (en) | 2006-10-19 | 2013-07-24 | Genzyme Corporation | Purine derivatives for the treatment of cystic diseases |
WO2008057604A2 (en) * | 2006-11-08 | 2008-05-15 | The Regents Of The University Of California | Small molecule therapeutics, syntheses of analogues and derivatives and methods of use |
EP2086326B1 (en) | 2006-11-13 | 2014-01-08 | Synta Pharmaceuticals Corp. | Cyclohexenyl-aryl compounds for inflammation and immune-related uses |
EP2091527B1 (en) | 2006-12-13 | 2016-03-23 | Temple University - Of The Commonwealth System of Higher Education | Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof |
CA2671766A1 (en) * | 2006-12-22 | 2008-07-03 | Encysive Pharmaceuticals, Inc. | Modulators of c3a receptor and methods of use thereof |
AU2007343726A1 (en) * | 2006-12-26 | 2008-07-24 | Amgen Inc. | N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases |
KR101227072B1 (en) * | 2007-01-16 | 2013-01-29 | 시오노기세이야쿠가부시키가이샤 | Heterocyclic-substituted piperidine as orl-1 ligands |
KR20180099916A (en) | 2007-02-09 | 2018-09-05 | 메타베이시스 테라퓨틱스, 인크. | Novel antagonists of the glucagon receptor |
JP5666140B2 (en) | 2007-02-21 | 2015-02-12 | サノヴィオン ファーマシューティカルズ インコーポレーテッド | Solids containing (-)-O-desmethylvenlafaxine and their use |
DK2144604T3 (en) * | 2007-02-28 | 2011-10-17 | Conatus Pharmaceuticals Inc | Methods for the treatment of chronic viral hepatitis C using RO 113-0830 |
WO2008106167A1 (en) * | 2007-02-28 | 2008-09-04 | Conatus Pharmaceuticals, Inc. | Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases |
SI2125698T1 (en) | 2007-03-15 | 2016-12-30 | Auspex Pharmaceuticals, Inc. | DEUTERATED d9-VENLAFAXINE |
EP2380564B1 (en) | 2007-04-04 | 2014-10-22 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
EP2061587A1 (en) | 2007-04-26 | 2009-05-27 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
JP5372913B2 (en) | 2007-04-27 | 2013-12-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | Effective treatment for pain |
AU2008243874B2 (en) | 2007-04-27 | 2012-01-19 | Purdue Pharma L.P. | TRPV1 antagonists and uses thereof |
US7892776B2 (en) | 2007-05-04 | 2011-02-22 | The Regents Of The University Of California | Screening assay to identify modulators of protein kinase A |
EP2019101A1 (en) * | 2007-07-26 | 2009-01-28 | GPC Biotech AG | Pyrazol[3,4-d]pyrimidin-4-one useful as Kinase Inhibitor |
CN103936605B (en) | 2007-05-31 | 2017-09-01 | 赛诺维信制药公司 | The cycloalkanes amine of phenyl substitution is used as monoamine reuptaking inhibitor |
EP2572712A3 (en) | 2007-06-01 | 2013-11-20 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
US8415294B2 (en) * | 2007-06-05 | 2013-04-09 | Arizona Board Of Regents | Cyclodepsipeptides with antineoplastic activity and methods of using to inhibit cancer and microbial growth |
BRPI0814409A2 (en) * | 2007-07-06 | 2014-10-14 | Nuon Therapeutics Inc | NEUROPATHIC PAIN TREATMENT |
MX2010000465A (en) * | 2007-07-12 | 2010-08-30 | Tragara Pharmaceuticals Inc | Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders. |
WO2009012263A2 (en) * | 2007-07-18 | 2009-01-22 | The Trustees Of Columbia University In The City Of New York | Tissue-specific micrornas and compositions and uses thereof |
US8435996B2 (en) | 2007-08-01 | 2013-05-07 | Synta Pharmaceuticals Corp. | Heterocycle-aryl compounds for inflammation and immune-related uses |
WO2009017831A1 (en) | 2007-08-01 | 2009-02-05 | Synta Pharmaceuticals Corp. | Vinyl-aryl derivatives for inflammation and immune-related uses |
US7893045B2 (en) | 2007-08-07 | 2011-02-22 | Celgene Corporation | Methods for treating lymphomas in certain patient populations and screening patients for said therapy |
CA2695583A1 (en) | 2007-08-13 | 2009-02-19 | Metabasis Therapeutics, Inc. | Novel activators of glucokinase |
US20090062242A1 (en) * | 2007-08-28 | 2009-03-05 | Agi Therapeutics Plc | Methods and compositions for treating gastrointestinal conditions |
NZ582940A (en) | 2007-08-31 | 2013-01-25 | Purdue Pharma Lp | Substituted-quinoxaline-type piperidine compounds and the uses thereof |
CA2699151A1 (en) * | 2007-09-11 | 2009-03-19 | Activx Biosciences, Inc. | Cyanoaminoquinolones and tetrazoloaminoquinolones as gsk-3 inhibitors |
MX2010002662A (en) | 2007-09-12 | 2010-04-09 | Activx Biosciences Inc | Spirocyclic aminoquinolones as gsk-3 inhibitors. |
US8492395B2 (en) | 2007-09-26 | 2013-07-23 | Celgene Corporation | 7-substituted quinazolinone compounds and compositions comprising the same |
US20090264421A1 (en) * | 2007-10-05 | 2009-10-22 | Bible Keith C | Methods and Compositions for Treating Cancer |
KR20100082775A (en) * | 2007-10-16 | 2010-07-19 | 심포젠 에이/에스 | Compositions comprising optimized herl and her3 multimers and methods of use thereof |
US20110009463A1 (en) * | 2007-10-17 | 2011-01-13 | Yuri Karl Petersson | Geranylgeranyl transferase inhibitors and methods of making and using the same |
CA2702494A1 (en) | 2007-10-19 | 2009-04-23 | The Regents Of The University Of California | Compositions and methods for ameliorating cns inflammation, psychosis, delirium, ptsd or ptss |
US8293513B2 (en) | 2007-12-14 | 2012-10-23 | Georgetown University | Histone deacetylase inhibitors |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
EP2240022B1 (en) | 2008-01-09 | 2016-12-28 | Charleston Laboratories, Inc. | Bilayered tablets comprising oxycodone and promethazine |
WO2009111611A2 (en) * | 2008-03-05 | 2009-09-11 | Proteotech Inc. | Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes |
TWI395593B (en) | 2008-03-06 | 2013-05-11 | Halozyme Inc | In vivo temporal control of activatable matrix-degrading enzymes |
US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
MY161576A (en) | 2008-03-17 | 2017-04-28 | Ambit Biosciences Corp | Quinazoline derivatives as raf kinase modulators and methods of use thereof |
US9249147B2 (en) | 2008-03-19 | 2016-02-02 | Chembridge Corporation | Tyrosine kinase inhibitors |
JP5628145B2 (en) | 2008-03-19 | 2014-11-19 | ケムブリッジ・コーポレーション | Novel tyrosine kinase inhibitor |
US8822500B2 (en) | 2008-03-19 | 2014-09-02 | Chembridge Corporation | Tyrosine kinase inhibitors |
KR20150038547A (en) | 2008-03-27 | 2015-04-08 | 셀진 코포레이션 | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
EP2687213B1 (en) | 2008-03-27 | 2019-01-23 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
KR101647932B1 (en) | 2008-04-14 | 2016-08-11 | 할로자임, 아이엔씨 | Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions |
US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
EP2112152A1 (en) | 2008-04-22 | 2009-10-28 | GPC Biotech AG | Dihydropteridinones as Plk Inhibitors |
EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
US9314469B2 (en) | 2008-05-05 | 2016-04-19 | Tonix Pharma Holdings Limited | Method for treating neurocognitive dysfunction |
WO2009139880A1 (en) * | 2008-05-13 | 2009-11-19 | Celgene Corporation | Thioxoisoindoline compounds and compositions and methods of using the same |
CA2724594A1 (en) * | 2008-05-20 | 2009-11-26 | John R. Wetterau | Niacin and nsaid combination therapy |
EP2318035B1 (en) | 2008-07-01 | 2019-06-12 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
TW201004632A (en) | 2008-07-02 | 2010-02-01 | Idenix Pharmaceuticals Inc | Compounds and pharmaceutical compositions for the treatment of viral infections |
CN102105465B (en) | 2008-07-21 | 2015-03-11 | 普渡制药公司 | Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof |
KR101343395B1 (en) | 2008-07-30 | 2013-12-19 | 퍼듀 퍼머 엘피 | Buprenorphine analogs |
EP3153501B1 (en) | 2008-08-13 | 2018-11-28 | Metabasis Therapeutics, Inc. | Glucagon antagonists |
WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
EP2340254B8 (en) | 2008-09-15 | 2014-05-21 | Biovista, Inc. | Compositions and methods for treating epilepsy |
TW201026693A (en) * | 2008-10-01 | 2010-07-16 | Synta Pharmaceuticals Corp | Compounds for inflammation and immune-related uses |
EP2346329B1 (en) | 2008-10-09 | 2013-08-21 | Anadys Pharmaceuticals, Inc. | A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds |
CA2740107A1 (en) * | 2008-10-10 | 2010-04-15 | Purdue Research Foundation | Compounds for treatment of alzheimer's disease |
US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
US8546388B2 (en) * | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
US8703962B2 (en) * | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
PL2358697T3 (en) | 2008-10-29 | 2016-04-29 | Celgene Corp | Isoindoline compounds for use in the treatment of cancer. |
WO2010059953A1 (en) * | 2008-11-20 | 2010-05-27 | Purdue Research Foundation | Quinazoline inhibitors of bace 1 and methods of using |
US8859590B2 (en) | 2008-12-05 | 2014-10-14 | Purdue Research Foundation | Inhibitors of BACE1 and methods for treating Alzheimer's disease |
PT3037529T (en) | 2008-12-09 | 2019-05-31 | Halozyme Inc | Extended soluble ph20 polypeptides and uses thereof |
AU2009330355B2 (en) | 2008-12-16 | 2016-06-30 | Sunovion Pharmaceuticals Inc. | Triple reuptake inhibitors and methods of their use |
US20110306605A1 (en) | 2008-12-22 | 2011-12-15 | Sloan-Kettering Institute For Cancer Research | Coumarin-based compounds for the treatment of alzheimer's disease and cancer |
JP2012513468A (en) | 2008-12-22 | 2012-06-14 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | Methods for treating or preventing cancer and neurodegenerative diseases |
CN102307892A (en) | 2008-12-31 | 2012-01-04 | 西尼克斯公司 | Derivatives of cyclosporin A |
NZ593823A (en) | 2009-01-06 | 2013-09-27 | Curelon Llc | Compositions and methods for the treatment or the prevention of infections by e. coli |
AU2010203709B2 (en) | 2009-01-06 | 2014-05-22 | Galenagen, Llc | Compositions and methods for the treatment or prevention of Staphylococcus Aureus infections and for the Eradication or reduction of Staphylococcus Aureus on surfaces |
WO2010088450A2 (en) | 2009-01-30 | 2010-08-05 | Celladon Corporation | Methods for treating diseases associated with the modulation of serca |
US8389559B2 (en) | 2009-02-09 | 2013-03-05 | Sunovion Pharmaceuticals Inc. | Pyrrolidine triple reuptake inhibitors |
EA201171035A1 (en) | 2009-02-10 | 2012-02-28 | Селджин Корпорейшн | COMPOSITIONS, INCLUDING MODULATORS PDE4, AND METHOD OF THEIR APPLICATION FOR THE TREATMENT, PREVENTION AND SUPPORT OF TUBERCULOSIS |
CN102388043A (en) | 2009-02-11 | 2012-03-21 | 桑诺维恩药品公司 | Histamine h3 inverse agonists and antagonists and methods of use thereof |
US20120053159A1 (en) | 2009-02-11 | 2012-03-01 | Muller George W | Isotopologues of lenalidomide |
US8568793B2 (en) | 2009-02-11 | 2013-10-29 | Hope Medical Enterprises, Inc. | Sodium nitrite-containing pharmaceutical compositions |
JP2012518635A (en) | 2009-02-24 | 2012-08-16 | リター ファーマシューティカルズ インコーポレイテッド | Prebiotic formulations and methods of use |
US20120065221A1 (en) | 2009-02-26 | 2012-03-15 | Theraquest Biosciences, Inc. | Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use |
WO2010099379A1 (en) | 2009-02-27 | 2010-09-02 | Ambit Biosciences Corporation | Jak kinase modulating quinazoline derivatives and methods of use thereof |
WO2010101967A2 (en) | 2009-03-04 | 2010-09-10 | Idenix Pharmaceuticals, Inc. | Phosphothiophene and phosphothiazole hcv polymerase inhibitors |
US20110229451A2 (en) * | 2009-03-06 | 2011-09-22 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloproteases and uses thereof |
JP2012520314A (en) | 2009-03-11 | 2012-09-06 | アムビト ビオスシエンセス コルポラチオン | Combination of indazolylaminopyrrolotriazine and taxane for cancer treatment |
EP2406266B1 (en) * | 2009-03-11 | 2013-12-25 | Kyorin Pharmaceutical Co., Ltd. | 7-cycloalkylaminoquinolones as gsk-3 inhibitors |
MX2011010105A (en) | 2009-03-27 | 2012-01-12 | Pathway Therapeutics Inc | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy. |
WO2010110686A1 (en) | 2009-03-27 | 2010-09-30 | Pathway Therapeutics Limited | Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy |
US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
AU2010239311B2 (en) | 2009-04-20 | 2014-05-22 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
EP2421829B1 (en) | 2009-04-22 | 2015-09-30 | Axikin Pharmaceuticals, Inc. | 2,5-disubstituted arylsulfonamide ccr3 antagonists |
PE20120811A1 (en) | 2009-04-22 | 2012-07-08 | Axikin Pharmaceuticals Inc | CCR3 ARYLSULFONAMIDE ANTAGONISTS |
MX357611B (en) | 2009-04-22 | 2018-07-17 | Axikin Pharmaceuticals Inc | 2,5-disubstituted arylsulfonamide ccr3 antagonists. |
EP2429992A4 (en) * | 2009-05-15 | 2012-11-28 | Univ Kentucky Res Found | Treatment of mci and alzheimer's disease |
US9968574B2 (en) * | 2009-05-15 | 2018-05-15 | The University Of Kentucky Research Foundation | Treatment of MCI and Alzheimer's disease |
GB2483815B (en) | 2009-05-18 | 2013-12-25 | Sigmoid Pharma Ltd | Composition comprising oil drops |
WO2010137547A1 (en) | 2009-05-25 | 2010-12-02 | 国立大学法人東京工業大学 | Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells |
AU2010258785A1 (en) | 2009-06-10 | 2012-01-19 | Sunovion Pharmaceuticals Inc. | Histamine H3 inverse agonists and antagonists and methods of use thereof |
US9050276B2 (en) | 2009-06-16 | 2015-06-09 | The Trustees Of Columbia University In The City Of New York | Autism-associated biomarkers and uses thereof |
WO2011003870A2 (en) | 2009-07-06 | 2011-01-13 | Creabilis S.A. | Mini-pegylated corticosteroids, compositions including same, and methods of making and using same |
AR080945A1 (en) | 2009-07-07 | 2012-05-23 | Pathway Therapeutics Inc | PIRIMIDINIL AND 1,3,5-TRIAZINIL BENZIMIDAZOLES AND ITS USE IN THERAPY AGAINST CANCER |
EP2451274B1 (en) | 2009-07-08 | 2017-10-04 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
HUE035519T2 (en) | 2009-07-08 | 2018-05-02 | Hope Medical Entpr Inc D B A Hope Pharmaceuticals | Sodium thiosulfate-containing pharmaceutical compositions |
EP2467144A1 (en) | 2009-07-24 | 2012-06-27 | ViroLogik GmbH | Combination of proteasome inhibitors and anti-hepatitis medication for treating hepatitis |
US8404728B2 (en) | 2009-07-30 | 2013-03-26 | Mayo Foundation For Medical Education And Research | Small-molecule botulinum toxin inhibitors |
WO2011014775A1 (en) | 2009-07-31 | 2011-02-03 | The Brigham And Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
EP2464341B1 (en) | 2009-08-12 | 2022-07-06 | Sublimity Therapeutics Limited | Immunomodulatory compositions comprising a polymer matrix and an oil phase |
BR112012003661A2 (en) | 2009-08-19 | 2017-04-25 | Ambit Biosciences Corp | "Biaryl compounds and methods of use thereof." |
US20120190743A1 (en) | 2009-09-04 | 2012-07-26 | United Paragon Associates Inc. | Compounds for treating disorders or diseases associated with neurokinin 2 receptor activity |
US20120172350A1 (en) | 2009-09-11 | 2012-07-05 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
US20110136751A1 (en) | 2009-10-06 | 2011-06-09 | Green Molecular | Use of Polyphenols in the Treatment of Cancer |
US20120245186A1 (en) | 2009-10-19 | 2012-09-27 | Synta Pharmaceuticals Corp. | Combination cancer therapy with hsp90 inhibitory compounds |
US8470817B2 (en) * | 2009-10-26 | 2013-06-25 | Sunesis Pharmaceuticals, Inc. | Compounds and methods for treatment of cancer |
EP2325185A1 (en) | 2009-10-28 | 2011-05-25 | GPC Biotech AG | Plk inhibitor |
WO2011056764A1 (en) | 2009-11-05 | 2011-05-12 | Ambit Biosciences Corp. | Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles |
US20110117055A1 (en) | 2009-11-19 | 2011-05-19 | Macdonald James E | Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds |
MX2012004741A (en) | 2009-11-19 | 2012-05-22 | Celgene Corp | Apremilast for the treatment of sarcoidosis. |
PL2501234T3 (en) * | 2009-11-20 | 2018-01-31 | Tonix Pharma Holdings Ltd | Methods and compositions for treating symptoms associated with post-traumatic stress disorder using cyclobenzaprine |
WO2011064769A1 (en) | 2009-11-24 | 2011-06-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods and pharmaceutical compositions for the treatment of hot flashes |
US20110301235A1 (en) | 2009-12-02 | 2011-12-08 | Alquest Therapeutics, Inc. | Organoselenium compounds and uses thereof |
RU2557059C2 (en) | 2009-12-04 | 2015-07-20 | Суновион Фармасьютикалз, Инк. | Polycyclic compound and methods of their application |
CA2782240A1 (en) | 2009-12-04 | 2011-06-09 | Sunovion Pharmaceuticals Inc. | Formulations, salts and polymorphs of transnorsertraline and uses thereof |
WO2011070364A1 (en) | 2009-12-09 | 2011-06-16 | Scynexis, Inc. | Novel cyclic peptides |
AR079528A1 (en) | 2009-12-18 | 2012-02-01 | Idenix Pharmaceuticals Inc | 5,5-FUSIONED ARYLENE OR HETEROARYLENE INHIBITORS OF HEPATITIS C VIRUS |
CN102770412A (en) | 2009-12-22 | 2012-11-07 | 细胞基因公司 | (Methylsulfonyl) ethyl benzene isoindoline derivatives and their therapeutical uses |
US8710092B2 (en) * | 2009-12-23 | 2014-04-29 | Map Pharmaceuticals, Inc. | Substituted indolo 4,3 FG quinolines useful for treating migraine |
CN102834409A (en) | 2009-12-30 | 2012-12-19 | 西尼克斯公司 | Cyclosporine analogues |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
ES2699692T3 (en) | 2010-01-04 | 2019-02-12 | Mapi Pharma Ltd | Deposit system comprising glatiramer acetate |
US9226913B2 (en) | 2010-01-05 | 2016-01-05 | Celgene Corporation | Methods of treating cancer using a combination of an immunomodulatory compound and an artemisinin or a derivative thereof |
WO2011089167A1 (en) | 2010-01-19 | 2011-07-28 | Virologik Gmbh | Kombination of proteasome inhibitors and anti -hepatitis medication for treating retroviral diseases |
WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
WO2011097525A1 (en) | 2010-02-05 | 2011-08-11 | Tragara Pharmaceuticals, Inc. | Solid state forms of macrocyclic kinase inhibitors |
SI2536706T1 (en) | 2010-02-11 | 2017-10-30 | Celgene Corporation | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
AU2011223873B2 (en) | 2010-03-02 | 2015-06-25 | Axikin Pharmaceuticals, Inc. | Isotopically enriched arylsulfonamide CCR3 antagonists |
WO2011112689A2 (en) | 2010-03-11 | 2011-09-15 | Ambit Biosciences Corp. | Saltz of an indazolylpyrrolotriazine |
JP2013522236A (en) * | 2010-03-12 | 2013-06-13 | セルジーン コーポレイション | Methods for treating non-Hodgkin lymphoma using lenalidomide, and gene and protein biomarkers as predictors |
EP2547655B1 (en) | 2010-03-17 | 2016-03-09 | Axikin Pharmaceuticals, Inc. | Arylsulfonamide ccr3 antagonists |
WO2011116287A1 (en) | 2010-03-19 | 2011-09-22 | Purdue Research Foundation | Ccr5 modulators for treating hiv |
MX341050B (en) | 2010-04-07 | 2016-08-05 | Celgene Corp * | Methods for treating respiratory viral infection. |
AU2011237592B2 (en) | 2010-04-08 | 2016-10-27 | Emory University | Substituted androst-4-ene diones |
US20130156755A1 (en) | 2010-04-19 | 2013-06-20 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor |
EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
EP3202406A1 (en) | 2010-04-28 | 2017-08-09 | Ritter Pharmaceuticals, Inc. | Prebiotic formulations and methods of use |
WO2011140360A1 (en) | 2010-05-05 | 2011-11-10 | The Trustees Of Columbia University In The City Of New York | Radiolabeled compounds and uses thereof |
WO2011146803A1 (en) | 2010-05-20 | 2011-11-24 | Synta Pharmaceuticals Corp. | Method of treating lung adenocarcinoma with hsp90 inhibitory compounds |
US20130171105A1 (en) | 2010-05-24 | 2013-07-04 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compound and a topoisomerase ii inhibitor |
WO2011150156A2 (en) | 2010-05-26 | 2011-12-01 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
WO2011150201A2 (en) | 2010-05-27 | 2011-12-01 | Ambit Biosciences Corporation | Azolyl amide compounds and methods of use thereof |
WO2011150198A1 (en) | 2010-05-27 | 2011-12-01 | Ambit Biosciences Corporation | Azolyl urea compounds and methods of use thereof |
EP2576520A1 (en) | 2010-05-28 | 2013-04-10 | GE Healthcare UK Limited | Radiolabeled compounds and methods thereof |
CA2801001A1 (en) | 2010-06-01 | 2011-12-08 | Biotheryx, Inc. | Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases |
EP2585063A1 (en) | 2010-06-01 | 2013-05-01 | Biotheryx Inc. | Methods of treating hematologic malignancies using 6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridone |
MX2012014273A (en) | 2010-06-07 | 2013-03-22 | Novomedix Llc | Furanyl compounds and the use thereof. |
US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
US20130178522A1 (en) | 2010-07-19 | 2013-07-11 | James M. Jamison | Vitamin c and chromium-free vitamin k, and compositions thereof for treating an nfkb-mediated condition or disease |
ES2591355T3 (en) | 2010-08-24 | 2016-11-28 | Algiax Pharmaceuticals Gmbh | Novel use of leflunomide and malononitrilamides |
WO2012030913A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
EP2611794A1 (en) | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | 4-azolylaminoquinazoline derivatives and methods of use thereof |
WO2012030924A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Azolopyridine and azolopyrimidine compounds and methods of use thereof |
US20130225578A1 (en) | 2010-09-01 | 2013-08-29 | Ambit Biosciences Corporation | 7-cyclylquinazoline derivatives and methods of use thereof |
WO2012030894A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Thienopyridine and thienopyrimidine compounds and methods of use thereof |
KR20130102060A (en) | 2010-09-01 | 2013-09-16 | 암비트 바이오사이언시즈 코포레이션 | Quinazoline compounds and methods of use thereof |
WO2012030910A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | 2-cycloquinazoline derivatives and methods of use thereof |
EP2611792B1 (en) | 2010-09-01 | 2017-02-01 | Ambit Biosciences Corporation | Hydrobromide salts of a pyrazolylaminoquinazoline |
EP2611502A1 (en) | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | Adenosine a3 receptor modulating compounds and methods of use thereof |
US20130296363A1 (en) | 2010-09-01 | 2013-11-07 | Ambit Biosciences Corporation | Quinoline and isoquinoline derivatives for use as jak modulators |
JP2013537229A (en) | 2010-09-13 | 2013-09-30 | シンタ ファーマシューティカルズ コーポレーション | HSP90 inhibitors for treating non-small cell lung cancer in patients with wild type EGFR and / or KRAS |
WO2012044641A1 (en) | 2010-09-29 | 2012-04-05 | Pathway Therapeutics Inc. | 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
MX2013003954A (en) | 2010-10-11 | 2013-08-01 | Axikin Pharmaceuticals Inc | Salts of arylsulfonamide ccr3 antagonists. |
EP2627349B1 (en) | 2010-10-15 | 2016-02-03 | The Trustees of Columbia University in the City of New York | Obesity-related genes and their proteins and uses thereof |
MX337179B (en) | 2010-10-18 | 2016-02-15 | Cerenis Therapeutics Holding Sa | Compounds, compositions and methods useful for cholesterol mobilisation. |
CA2814371C (en) | 2010-10-29 | 2019-03-19 | Algiax Pharmaceuticals Gmbh | Use of malononitrilamides in neuropathic pain |
WO2012064808A1 (en) | 2010-11-09 | 2012-05-18 | Synta Pharmaceuticals Corp | Tetrazolyl - tetrahydropyridine compounds for inflammation and immune - related uses |
EP2637669A4 (en) | 2010-11-10 | 2014-04-02 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
AU2011338530B2 (en) | 2010-12-06 | 2017-06-15 | Follica, Inc. | Methods for treating baldness and promoting hair growth |
WO2012078492A1 (en) | 2010-12-06 | 2012-06-14 | Celgene Corporation | A combination therapy with lenalidomide and a cdk inhibitor for treating multiple myeloma |
EP2648708A2 (en) | 2010-12-08 | 2013-10-16 | Synta Pharmaceuticals Corp. | Combination for breast cancer therapy with hsp90 inhibitory compounds |
WO2012080050A1 (en) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Solid forms of a phenoxybenzenesulfonyl compound |
US9532977B2 (en) | 2010-12-16 | 2017-01-03 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
EP2651400B2 (en) | 2010-12-16 | 2023-01-18 | Amgen (Europe) GmbH | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
EP2654751B1 (en) | 2010-12-22 | 2016-11-23 | Purdue Pharma L.P. | Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof |
PT2661266T (en) | 2011-01-07 | 2020-11-30 | Anji Pharma Us Llc | Chemosensory receptor ligand-based therapies |
WO2013103919A2 (en) | 2012-01-06 | 2013-07-11 | Elcelyx Therapeutics, Inc. | Compositions and methods for treating metabolic disorders |
WO2012096884A1 (en) | 2011-01-10 | 2012-07-19 | Celgene Corporation | Phenethylsulfone isoindoline derivatives as inhibitors of pde 4 and/or cytokines |
CN103391770A (en) | 2011-01-10 | 2013-11-13 | 细胞基因公司 | Oral dosage forms of cyclopropanecarboxylic acid {2-[(1s)-1-(3-ethoxy-4-methoxy-phenyl]-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1h-isoindol-4-yl}-amide |
CA2824197C (en) | 2011-01-10 | 2020-02-25 | Michael Martin | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
EP2663305A1 (en) | 2011-01-11 | 2013-11-20 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with proteasome inhibitors |
AU2012205687B2 (en) | 2011-01-11 | 2017-03-16 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
US9045417B2 (en) | 2011-01-14 | 2015-06-02 | Celgene Corporation | Isotopologues of isoindole derivatives |
EP3042654A1 (en) | 2011-01-20 | 2016-07-13 | Bionevia Pharmaceuticals Inc. | Modified release compositions of epalrestat or a derivative thereof and methods for using the same |
WO2012106281A2 (en) | 2011-01-31 | 2012-08-09 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
JP2014503597A (en) | 2011-01-31 | 2014-02-13 | セルジーン コーポレイション | Pharmaceutical composition of cytidine analogue and method of use thereof |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
WO2012116061A1 (en) | 2011-02-23 | 2012-08-30 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with radiotherapy |
WO2012141796A2 (en) | 2011-02-24 | 2012-10-18 | Synta Pharmaceuticals Corp. | Prostate cancer therapy with hsp90 inhibitory compounds |
US20140045908A1 (en) | 2011-02-25 | 2014-02-13 | Synta Pharmaceuticals Corp. | Hsp90 inhibitory compounds in treating jak/stat signaling-mediated cancers |
US9795792B2 (en) | 2011-02-25 | 2017-10-24 | Medtronic, Inc. | Emergency mode switching for non-pacing modes |
WO2012121988A2 (en) | 2011-03-07 | 2012-09-13 | Celgene Corporation | Methods for treating diseases using isoindoline compounds |
US20120232159A1 (en) | 2011-03-07 | 2012-09-13 | Tonix Pharmaceuticals, Inc. | Methods and Compositions for Treating Depression using Cyclobenzaprine |
KR20140014221A (en) | 2011-03-11 | 2014-02-05 | 셀진 코포레이션 | Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
MX2013010217A (en) | 2011-03-11 | 2013-10-25 | Celgene Corp | Use of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl)piperidine-2- 6-dione in treatment of immune-related and inflammatory diseases. |
WO2012123353A1 (en) | 2011-03-17 | 2012-09-20 | Algiax Pharmaceuticals Gmbh | Novel use of benzofuranylsulfonates |
EP2685983B1 (en) | 2011-03-17 | 2016-05-18 | Algiax Pharmaceuticals GmbH | Novel use of imidazotriazinones |
WO2012129237A2 (en) | 2011-03-20 | 2012-09-27 | Trustees Of Boston University | Therapeutic agent for emphysema and copd |
WO2012135166A1 (en) | 2011-03-28 | 2012-10-04 | Pathway Therapeutics Inc. | (fused ring arylamino and heterocyclylamino) pyrimidynyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
CA2867134C (en) | 2011-03-28 | 2019-05-07 | Sheila Dewitt | 2',6'-dioxo-3'-deutero-piperdin-3-yl-isoindoline compounds |
BR112013024907A2 (en) | 2011-03-28 | 2016-12-20 | Mei Pharma Inc | compound, pharmaceutical composition, method for treating, preventing or attenuating one or more symptoms of a pi3k-mediated disorder, disease or condition in a subject, method for modulating pi3k enzymatic activity |
CA2831590A1 (en) | 2011-03-28 | 2012-10-04 | Mei Pharma, Inc. | (alpha-substituted cycloalkylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
CA2843324A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
US20120252721A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
US20120321590A1 (en) | 2011-04-06 | 2012-12-20 | Anadys Pharmaceuticals, Inc. | Bridged polycyclic compounds |
WO2012143924A1 (en) | 2011-04-21 | 2012-10-26 | Mapi Pharma Ltd. | Random pentapolymer for treatment of autoimmune diseases |
DK2701733T3 (en) | 2011-04-21 | 2019-05-27 | Curemark Llc | CONNECTIONS FOR TREATMENT OF NEUROPSYCIATRIC DISORDERS |
WO2012149251A1 (en) | 2011-04-28 | 2012-11-01 | Celgene Corporation | Methods and compositions using pde4 inhibitors for the treatment and management of autoimmune and inflammatory diseases |
KR20140024914A (en) | 2011-04-29 | 2014-03-03 | 셀진 코포레이션 | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
EP2704701B1 (en) | 2011-05-03 | 2018-01-03 | PRCL Research Inc. | Compounds for inflammation and immune-related uses |
EP2704726B1 (en) | 2011-05-04 | 2018-10-31 | Trustees of Boston University | Proton-motive force stimulation to potentiate aminoglycoside antibiotics against persistent bacteria |
WO2012162372A1 (en) | 2011-05-24 | 2012-11-29 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mtor/p13k inhibitors |
CN103747787A (en) | 2011-05-27 | 2014-04-23 | 坦普尔大学 | Substituted 2-benzylidene-2h-benzo[b][1,4]thiazin-3(4h)-ones, derivatives thereof, and therapeutic uses thereof |
WO2012170536A1 (en) | 2011-06-07 | 2012-12-13 | Anadys Pharmaceuticals, Inc. | [1,2,4]thiadiazine 1,1-dioxide compounds for lowering serum uric acid |
RU2011122942A (en) | 2011-06-08 | 2012-12-20 | Общество С Ограниченной Ответственностью "Асинэкс Медхим" | NEW KINAZ INHIBITORS |
CN105693712A (en) | 2011-06-22 | 2016-06-22 | 普渡制药公司 | TRPV1 antagonists including dihydroxy substituent and uses thereof |
WO2012177678A2 (en) | 2011-06-22 | 2012-12-27 | Celgene Corporation | Isotopologues of pomalidomide |
CN103827113A (en) | 2011-06-23 | 2014-05-28 | Map药物公司 | Novel fluoroergoline analogs |
US20140227293A1 (en) | 2011-06-30 | 2014-08-14 | Trustees Of Boston University | Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1) |
JP2014520808A (en) | 2011-07-07 | 2014-08-25 | シンタ ファーマシューティカルズ コーポレーション | Treatment of cancer using HSP90 inhibitor compounds |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2842190A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
GB201112987D0 (en) | 2011-07-28 | 2011-09-14 | Ge Healthcare Ltd | Novel compound |
WO2013022872A1 (en) | 2011-08-10 | 2013-02-14 | Celgene Corporation | Gene methylation biomarkers and methods of use thereof |
WO2013021276A1 (en) | 2011-08-10 | 2013-02-14 | Purdue Pharma L.P. | Trpv1 antagonists including dihydroxy substituent and uses thereof |
CN103930126A (en) | 2011-08-12 | 2014-07-16 | Bsrc亚历山大.弗莱明 | TNF superfamily trimerization inhibitors |
EP2744494A1 (en) | 2011-08-19 | 2014-06-25 | Synta Pharmaceuticals Corporation | Combination cancer therapy of hsp90 inhibitor with antimetabolite |
DK2959899T3 (en) | 2011-08-23 | 2017-05-01 | Cornerstone Therapeutics Inc | Use of zileuton for the treatment of nasal polyps in patients with cystic fibrosis |
RU2014111823A (en) | 2011-08-29 | 2015-10-10 | Инфинити Фармасьютикалз, Инк. | HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS |
AR088441A1 (en) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | SUBSTITUTED CARBONYLOXYMETHYLPHOSPHORAMIDATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS |
EP2755985B1 (en) | 2011-09-12 | 2017-11-01 | Idenix Pharmaceuticals LLC | Compounds and pharmaceutical compositions for the treatment of viral infections |
WO2013040501A1 (en) | 2011-09-16 | 2013-03-21 | Pharmathene, Inc. | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof |
AU2012312308B2 (en) | 2011-09-23 | 2015-11-19 | Celgene Corporation | Romidepsin and 5-azacitidine for use in treating lymphoma |
WO2013049093A1 (en) | 2011-09-26 | 2013-04-04 | Celgene Corporation | Combination therapy for chemoresistant cancers |
US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
EP2764406B1 (en) | 2011-10-07 | 2018-03-14 | Cedars-Sinai Medical Center | Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties |
WO2013055985A1 (en) | 2011-10-12 | 2013-04-18 | Children's Medical Center Corporation | Combinatorial compositions and methods of treating hemoglobinopathies |
WO2013056070A2 (en) | 2011-10-14 | 2013-04-18 | Ambit Biosciences Corporation | Heterocyclic compounds and methods of use thereof |
AR089650A1 (en) | 2011-10-14 | 2014-09-10 | Idenix Pharmaceuticals Inc | PHOSPHATES 3,5-REPLACED CYCLES OF PURINE NUCLEOTIDE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS |
KR20140088603A (en) | 2011-11-01 | 2014-07-10 | 셀진 코포레이션 | Methods for treating cancers using oral formulations of cytidine analogs |
US20140286902A1 (en) | 2011-11-02 | 2014-09-25 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with platinum-containing agents |
JP2014532712A (en) | 2011-11-02 | 2014-12-08 | シンタ ファーマシューティカルズ コーポレーション | Cancer therapy using a combination of a topoisomerase I inhibitor and an HSP90 inhibitor |
US9243037B2 (en) | 2011-11-10 | 2016-01-26 | Trustees Of Boston College | Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity |
JP2014533299A (en) | 2011-11-14 | 2014-12-11 | シンタ ファーマシューティカルズ コーポレーション | Combination therapy of BRAF inhibitor and HSP90 inhibitor |
US9290488B2 (en) | 2011-12-01 | 2016-03-22 | Purdue Pharma L.P. | Azetidine-substituted quinoxalines as opioid receptor like-1 modulators |
US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
WO2013085902A1 (en) | 2011-12-05 | 2013-06-13 | The University Of Texas M.D. | Combination therapy methods for treating an inflammatory breast cancer |
WO2013084060A1 (en) | 2011-12-08 | 2013-06-13 | Purdue Pharma L.P. | Quaternized buprenorphine analogs |
SG10201509139QA (en) | 2011-12-19 | 2015-12-30 | Map Pharmaceuticals Inc | Novel iso-ergoline derivatives |
US8946420B2 (en) | 2011-12-21 | 2015-02-03 | Map Pharmaceuticals, Inc. | Neuromodulatory compounds |
PT3130347T (en) | 2011-12-30 | 2019-12-10 | Halozyme Inc | Ph20 polypeptide variants, formulations and uses thereof |
RU2674153C2 (en) | 2012-01-05 | 2018-12-05 | Бостон Медикал Сентер Корпорэйшн | Slit-robo signalling for diagnosis and treatment of kidney disease |
ES2832773T3 (en) | 2012-01-06 | 2021-06-11 | Anji Pharma Us Llc | Biguanide compositions and methods of treatment of metabolic disorders |
AU2013216935C1 (en) | 2012-02-08 | 2017-12-14 | John Emmerson Campbell | Heteroaryl compounds and methods of use thereof |
WO2013126394A1 (en) | 2012-02-21 | 2013-08-29 | Celgene Corporation | Solid forms of 3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
US20150018362A1 (en) | 2012-02-27 | 2015-01-15 | Biovista, Inc. | Compositions and methods for treating mitochondrial diseases |
WO2013130600A1 (en) | 2012-02-29 | 2013-09-06 | Ambit Biosciences Corporation | Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith |
WO2013133708A1 (en) | 2012-03-07 | 2013-09-12 | Stichting Vu-Vumc | Compositions and methods for diagnosing and treating intellectual disability syndrome, autism and autism related disorders |
US8916555B2 (en) | 2012-03-16 | 2014-12-23 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
ES2779698T3 (en) | 2012-03-19 | 2020-08-18 | Brigham & Womens Hospital Inc | Growth differentiation factor 11 (GDF) for the treatment of age-related cardiovascular conditions |
WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
US20140350087A9 (en) | 2012-03-22 | 2014-11-27 | Halozyme, Inc. | Oncovector Nucleic Acid Molecules and Methods of Use |
WO2013148864A1 (en) | 2012-03-27 | 2013-10-03 | Andrei Gudkov | Curaxins for use in treating breast cancer and method for identifying patients likely to respond |
US20150051203A1 (en) | 2012-03-28 | 2015-02-19 | Synta Pharmaceuticals Corp. | Triazole derivatives as hsp90 inhibitors |
CA2868323A1 (en) | 2012-04-04 | 2013-10-10 | Synta Pharmaceuticals Corp. | Novel triazole compounds that modulate hsp90 activity |
CA2986512C (en) | 2012-04-04 | 2022-05-17 | Halozyme, Inc. | Combination therapy with an anti-hyaluronan agent and a tumor-targeted taxane |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2013156231A1 (en) | 2012-04-16 | 2013-10-24 | Algiax Pharmaceuticals Gmbh | Use of imidazotriazinones in neuropathic pain |
WO2013156232A1 (en) | 2012-04-16 | 2013-10-24 | Algiax Pharmaceuticals Gmbh | Use of benzofuranylsulfonates in neuropathic pain |
TW201811332A (en) | 2012-04-17 | 2018-04-01 | 美商普渡製藥有限合夥事業 | Systems and methods for treating an opioid-induced adverse pharmacodynamic response |
WO2013158928A2 (en) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
CA3095012C (en) | 2012-05-01 | 2023-02-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
EP2849751A1 (en) | 2012-05-10 | 2015-03-25 | Synta Pharmaceuticals Corp. | Treating cancer with hsp90 inhibitory compounds |
GB201208315D0 (en) | 2012-05-11 | 2012-06-27 | Numedicus Ltd | Pharmaceutical methods and compositions |
CA2870605A1 (en) | 2012-05-11 | 2013-11-14 | Purdue Pharma L.P. | Benzomorphan compounds as opioid receptors modulators |
WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
US9296778B2 (en) | 2012-05-22 | 2016-03-29 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphate prodrugs for HCV infection |
PE20150132A1 (en) | 2012-05-22 | 2015-02-14 | Idenix Pharmaceuticals Inc | D-AMINO ACID COMPOUNDS FOR HEPATIC DISEASE |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
EP3406598B1 (en) | 2012-06-14 | 2020-01-29 | Mayo Foundation for Medical Education and Research | Pyrazole derivatives as inhibitors of stat3 |
US9789193B2 (en) | 2012-06-15 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compositions for treating cancer and methods for making the same |
US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
JP6318152B2 (en) | 2012-06-29 | 2018-04-25 | セルジーン コーポレイション | Methods for determining drug efficacy using cereblon-related proteins |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
JP2015522080A (en) | 2012-07-11 | 2015-08-03 | エルセリクス セラピューティクス インコーポレイテッド | Compositions for reducing cardiovascular metabolic risk comprising statins, biguanides, and additional agents |
US9034870B2 (en) | 2012-07-13 | 2015-05-19 | Purdue Research Foundation | Azaindenoisoquinoline topoisomerase I inhibitors |
US9085561B2 (en) | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
WO2014022332A1 (en) | 2012-07-31 | 2014-02-06 | The Brigham And Women's Hospital, Inc. | Modulation of the immune response |
UA114521C2 (en) | 2012-08-09 | 2017-06-26 | Селджин Корпорейшн | Salts and solid forms of (s)-3-(4-((4-morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same |
PL2882441T3 (en) | 2012-08-09 | 2020-09-21 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
TWI653977B (en) | 2012-08-09 | 2019-03-21 | 美商西建公司 | Method for treating cancer by using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoindolin-2-yl)hexahydropyridine-2,6-dione |
US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
WO2014030053A1 (en) | 2012-08-20 | 2014-02-27 | Rhodes Technologies | Systems and methods for increasing stability of dronabinol compositions |
US9315514B2 (en) | 2012-08-27 | 2016-04-19 | Rhodes Technologies | 1,3-dioxanomorphides and 1,3-dioxanocodides |
US9605074B2 (en) | 2012-08-30 | 2017-03-28 | The General Hospital Corporation | Multifunctional nanobodies for treating cancer |
CA2922849A1 (en) | 2012-08-31 | 2014-03-06 | Ixchel Pharma, Llc | Agents useful for treating obesity, diabetes and related disorders |
TW201414721A (en) | 2012-09-07 | 2014-04-16 | Axikin Pharmaceuticals Inc | Isotopically enriched arylsulfonamide CCR3 antagonists |
JP6306592B2 (en) | 2012-09-10 | 2018-04-04 | セルジーン コーポレイション | Methods for treating locally advanced breast cancer |
WO2014055647A1 (en) | 2012-10-03 | 2014-04-10 | Mei Pharma, Inc. | (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases |
AP2015008384A0 (en) | 2012-10-08 | 2015-04-30 | Univ Montpellier Ct Nat De La Rech Scient | 2'-Chloro nucleoside analogs for hcv infection |
KR102229873B1 (en) | 2012-10-12 | 2021-03-19 | 더 브리검 앤드 우먼즈 하스피털, 인크. | Enhancement of the immune response |
US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
US20140112886A1 (en) | 2012-10-19 | 2014-04-24 | Idenix Pharmaceuticals, Inc. | Dinucleotide compounds for hcv infection |
WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
PT2914296T (en) | 2012-11-01 | 2018-10-30 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
CA2890177A1 (en) | 2012-11-08 | 2014-05-15 | Summa Health System | Vitamin c, vitamin k, a polyphenol, and combinations thereof for wound healing |
US20150290171A1 (en) | 2012-11-09 | 2015-10-15 | Celgene Corporation | Methods for the treatment of bone loss |
EP2917182B1 (en) | 2012-11-09 | 2018-01-03 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
US20140140951A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-Alanine Ester of Rp-Nucleoside Analog |
US20140140952A1 (en) | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-Alanine Ester of Sp-Nucleoside Analog |
EP2925762B1 (en) | 2012-11-29 | 2017-07-05 | Sunovion Pharmaceuticals Inc. | Triazolo-pyrazine derivatives useful in the treatment of disorders of the central nervous system |
WO2014085633A1 (en) | 2012-11-30 | 2014-06-05 | Novomedix, Llc | Substituted biaryl sulfonamides and the use thereof |
WO2014087226A1 (en) | 2012-12-07 | 2014-06-12 | Purdue Pharma L.P. | Buprenorphine analogs as opiod receptor modulators |
ES2621305T3 (en) | 2012-12-14 | 2017-07-03 | Purdue Pharma Lp | Spirocyclic morphinans and their use |
TW201434836A (en) | 2012-12-14 | 2014-09-16 | Purdue Pharma Lp | Nitrogen containing morphinan derivatives and the use thereof |
WO2014091295A1 (en) | 2012-12-14 | 2014-06-19 | Purdue Pharma L.P. | Pyridonemorphinan analogs and biological activity on opioid receptors |
US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
EP2934143A4 (en) | 2012-12-21 | 2016-06-15 | Map Pharmaceuticals Inc | Novel methysergide derivatives |
WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
WO2014102590A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
WO2014102592A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
US9963458B2 (en) | 2012-12-27 | 2018-05-08 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
EP2941430B1 (en) | 2012-12-28 | 2017-04-26 | Purdue Pharma LP | 7,8-cyclicmorphinan analogs |
WO2014102593A1 (en) | 2012-12-28 | 2014-07-03 | Purdue Pharma L.P. | Substituted morphinans and the use thereof |
US9884844B2 (en) | 2012-12-31 | 2018-02-06 | Sunovion Pharmaceuticals, Inc. | Heterocyclic compounds and methods of use thereof |
SG10201705437SA (en) | 2013-01-05 | 2017-07-28 | Elcelyx Therapeutics Inc | Delayed-release composition comprising biguanide |
WO2014107745A1 (en) | 2013-01-07 | 2014-07-10 | Halozyme, Inc. | Metal sensitive mutants of matrix metalloproteases and uses thereof |
WO2014110127A1 (en) | 2013-01-08 | 2014-07-17 | Enzo Biochem, Inc. | Diagnosis and treatment of viral diseases |
US9617607B2 (en) | 2013-01-08 | 2017-04-11 | Enzo Biochem, Inc. | Diagnosis and treatment of viral diseases |
WO2014110305A1 (en) | 2013-01-11 | 2014-07-17 | Mayo Foundation For Medical Education And Research | Vitamins c and k for treating polycystic diseases |
AU2014205043B2 (en) | 2013-01-14 | 2018-10-04 | Deuterx, Llc | 3-(5-substituted-4-oxoquinazolin-3(4h)-yl)-3-deutero-piperidine-2,6-dione derivatives |
US9695145B2 (en) | 2013-01-22 | 2017-07-04 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
CN104955483A (en) | 2013-01-30 | 2015-09-30 | 法莫斯医疗公司 | Treatments for depression and other diseases with a low dose agent |
EP2951160B1 (en) | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
WO2014130922A1 (en) | 2013-02-25 | 2014-08-28 | Trustees Of Boston University | Compositions and methods for treating fungal infections |
WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
CN105050624A (en) | 2013-03-14 | 2015-11-11 | 细胞基因公司 | Treatment of psoriatic arthritis using apremilast |
US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
AU2014233277B2 (en) | 2013-03-15 | 2019-04-04 | Tonix Pharma Holdings Limited | Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride |
CN107056838A (en) | 2013-03-15 | 2017-08-18 | 加利福尼亚大学董事会 | Acyclic nucleoside phosphonate diester |
NZ629037A (en) | 2013-03-15 | 2017-04-28 | Infinity Pharmaceuticals Inc | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
CN105246480A (en) | 2013-04-02 | 2016-01-13 | 细胞基因公司 | Methods and compositions using 4-amino-2-(2, 6-dioxo-piperidine-3-yl)-isoindoline-1, 3-dione for treatment and management of central nervous system cancers |
EP4140497A1 (en) | 2013-04-08 | 2023-03-01 | President and Fellows of Harvard College | Compositions for rejuvenating skeletal muscle stem cells |
KR20160013204A (en) | 2013-05-30 | 2016-02-03 | 인피니티 파마슈티칼스, 인코포레이티드 | Treatment of cancers using pi3 kinase isoform modulators |
EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
CN105431144A (en) | 2013-06-05 | 2016-03-23 | 思康脑侒股份有限公司 | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US20160113911A1 (en) | 2013-06-06 | 2016-04-28 | The General Hospital Corporation | Methods and compositions for the treatment of cancer |
WO2014201143A1 (en) | 2013-06-11 | 2014-12-18 | President And Fellows Of Harvard College | Methods and compositions for increasing neurogenesis and angiogenesis |
BR112015031278B1 (en) | 2013-06-14 | 2022-05-17 | Akamara Therapeutics, Inc | Lipid-based platinum compounds and nanoparticles, their preparation processes, pharmaceutical compositions comprising the same and their uses in the treatment of cancer |
EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
US20160120861A1 (en) | 2013-06-28 | 2016-05-05 | Purdue Pharma L.P. | Compositions and Methods for Treating an Arrhythmia with an Opioid Antagonist |
TW201534726A (en) | 2013-07-03 | 2015-09-16 | Halozyme Inc | Thermally stable PH20 hyaluronidase variants and uses thereof |
WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
WO2015027146A1 (en) | 2013-08-22 | 2015-02-26 | The General Hospital Corporation | Inhibitors of human 12/15-lipoxygenase |
US11382883B2 (en) | 2013-08-29 | 2022-07-12 | Trustees Of Boston University | Intermediate metabolism products to potentiate aminoglycoside antibiotics in bacterial infections |
KR20160055170A (en) | 2013-08-30 | 2016-05-17 | 암비트 바이오사이언시즈 코포레이션 | Biaryl acetamide compounds and methods of use thereof |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
EP3046924A1 (en) | 2013-09-20 | 2016-07-27 | IDENIX Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
ES2729642T3 (en) | 2013-09-24 | 2019-11-05 | Purdue Pharma Lp | Treatment of burn pain using TRPV1 modulators |
US9700549B2 (en) | 2013-10-03 | 2017-07-11 | David Wise | Compositions and methods for treating pelvic pain and other conditions |
BR112016007467B1 (en) | 2013-10-04 | 2022-09-20 | Infinity Pharmaceuticals, Inc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US20160244452A1 (en) | 2013-10-21 | 2016-08-25 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
JP2016536303A (en) | 2013-10-21 | 2016-11-24 | ザ ジェネラル ホスピタル コーポレイション | Peripheral circulating tumor cell clusters and methods for cancer treatment |
WO2015061683A1 (en) | 2013-10-25 | 2015-04-30 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate and d-alanine thiophosphoramidate pronucleotides of nucleoside compounds useful for the treatment of hcv |
WO2015065876A1 (en) | 2013-10-29 | 2015-05-07 | Thomas Jefferson University | Methods of prevention or treatment for pathologic thrombosis or inflammation |
US20160271162A1 (en) | 2013-11-01 | 2016-09-22 | Idenix Pharmacueticals, Llc | D-alanine phosphoramide pronucleotides of 2'-methyl 2'-fluro guanosine nucleoside compounds for the treatment of hcv |
GB201319792D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
ES2860773T3 (en) | 2013-11-11 | 2021-10-05 | Naturex Inc | Compositions and methods useful in treating lower urinary tract symptoms, benign prostatic hyperplasia, erectile dysfunction |
EP4053560A1 (en) | 2013-11-26 | 2022-09-07 | The Brigham and Women's Hospital, Inc. | Compositions and methods for modulating an immune response |
WO2015081133A2 (en) | 2013-11-27 | 2015-06-04 | Idenix Pharmaceuticals, Inc. | Nucleotides for the treatment of liver cancer |
EP3074399A1 (en) | 2013-11-27 | 2016-10-05 | Idenix Pharmaceuticals LLC | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
CA2933335A1 (en) | 2013-12-11 | 2015-06-18 | The General Hospital Corporation | Use of mullerian inhibiting substance (mis) proteins for contraception and ovarian reserve preservation |
EP3083654A1 (en) | 2013-12-18 | 2016-10-26 | Idenix Pharmaceuticals LLC | 4'-or nucleosides for the treatment of hcv |
US9682123B2 (en) | 2013-12-20 | 2017-06-20 | The Trustees Of Columbia University In The City Of New York | Methods of treating metabolic disease |
CA2934344A1 (en) | 2013-12-20 | 2015-06-25 | David T. TING | Methods and assays relating to circulating tumor cells |
WO2015097548A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
WO2015097546A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Propellane-based compounds and their use as opioid receptor modulators |
EP3087079B1 (en) | 2013-12-26 | 2019-04-03 | Purdue Pharma LP | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
WO2015099863A1 (en) | 2013-12-27 | 2015-07-02 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
EP3089978B1 (en) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
EP3094328B1 (en) | 2014-01-15 | 2020-08-19 | Poxel SA | Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone |
EP3096749B1 (en) | 2014-01-24 | 2019-05-15 | Celgene Corporation | Methods for the treatment of obesity using apremilast |
US20170066779A1 (en) | 2014-03-05 | 2017-03-09 | Idenix Pharmaceuticals Llc | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
CA2942313C (en) | 2014-03-10 | 2023-02-07 | Kadmon Corporation, Llc | Treatment of brain and central nervous system tumors |
AU2015233686B2 (en) | 2014-03-18 | 2019-07-11 | Algiax Pharmaceuticals Gmbh | 2-Cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives |
CN113620958A (en) | 2014-03-19 | 2021-11-09 | 无限药品股份有限公司 | Heterocyclic compounds for the treatment of PI 3K-gamma mediated disorders |
CA2943231C (en) | 2014-03-20 | 2023-10-24 | Capella Therapeutics, Inc. | Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer |
US11369588B2 (en) | 2014-03-20 | 2022-06-28 | The Trustees Of Princeton University | NADPH production by the 10-formyl-THF pathway, and its use in the diagnosis and treatment of disease |
US10005765B2 (en) | 2014-03-20 | 2018-06-26 | Capella Therapeutics, Inc. | Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer |
WO2015143343A2 (en) | 2014-03-21 | 2015-09-24 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring |
CA2944401A1 (en) | 2014-04-03 | 2015-10-08 | Invictus Oncology Pvt. Ltd. | Supramolecular combinatorial therapeutics |
EP3125905A4 (en) | 2014-04-04 | 2017-11-08 | Ritter Pharmaceuticals, Inc. | Methods and compositions for microbiome alteration |
CA2944549A1 (en) | 2014-04-09 | 2015-10-15 | Siteone Therapeutics, Inc. | 10',11'-modified saxitoxin useful for the treatment of pain |
WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
EP3804745A1 (en) | 2014-04-25 | 2021-04-14 | The Brigham and Women's Hospital, Inc. | Methods to manipulate alpha-fetoprotein (afp) |
ES2830849T3 (en) | 2014-04-25 | 2021-06-04 | Brigham & Womens Hospital Inc | Assay and method for treating subjects with immune-mediated diseases |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
SG11201609256SA (en) | 2014-05-12 | 2016-12-29 | Conatus Pharmaceuticals Inc | Treatment of the complications of chronic liver disease with caspase inhibitors |
WO2015175773A1 (en) | 2014-05-15 | 2015-11-19 | Celgene Corporation | Use of pde4 inhibitors and combinations thereof for the treatment of cystic fibrosis |
WO2015175956A1 (en) | 2014-05-16 | 2015-11-19 | Celgene Corporation | Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators |
EP3145906B1 (en) | 2014-05-19 | 2023-10-04 | Northeastern University | Serotonin receptor-targeting compounds |
WO2015176780A1 (en) | 2014-05-23 | 2015-11-26 | Sigmoid Pharma Limited | Celecoxib formulations useful for treating colorectal cancer |
AU2015265607A1 (en) | 2014-05-28 | 2016-11-17 | Idenix Pharmaceuticals Llc | Nucleoside derivatives for the treatment of cancer |
US10456445B2 (en) | 2014-06-02 | 2019-10-29 | Children's Medical Center Corporation | Methods and compositions for immunomodulation |
WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
WO2015195634A1 (en) | 2014-06-17 | 2015-12-23 | Celgne Corporation | Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine |
WO2015195474A1 (en) | 2014-06-18 | 2015-12-23 | Biotheryx, Inc. | Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating inflammatory, neurodegenerative, or immune-mediated diseases |
GEP20197011B (en) | 2014-06-19 | 2019-08-12 | Ariad Pharma Inc | Heteroaryl compounds for kinase inhibition |
MX2016014384A (en) | 2014-06-23 | 2017-01-20 | Celgene Corp | Apremilast for the treatment of a liver disease or a liver function abnormality. |
EP3160486B1 (en) | 2014-06-27 | 2020-11-18 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases |
US9499514B2 (en) | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
WO2016019368A1 (en) | 2014-08-01 | 2016-02-04 | The Brigham And Women's Hospital, Inc. | Methods and compositions relating to treatment of pulmonary arterial hypertension |
WO2016025686A1 (en) | 2014-08-15 | 2016-02-18 | Celgene Corporation | Dosage titration of apremilast for the treatment of diseases ameliorated by pde4 inhibition |
PL3182996T3 (en) | 2014-08-22 | 2023-04-17 | Celgene Corporation | Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies |
WO2016033555A1 (en) | 2014-08-28 | 2016-03-03 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
JP2017526367A (en) | 2014-08-29 | 2017-09-14 | チルドレンズ メディカル センター コーポレーション | Methods and compositions for the treatment of cancer |
US20170319548A1 (en) | 2014-09-12 | 2017-11-09 | Tobira Therapeutics, Inc. | Cenicriviroc combination therapy for the treatment of fibrosis |
HRP20220651T1 (en) | 2014-09-15 | 2022-08-19 | The Regents Of The University Of California | Nucleotide analogs |
JP7095990B2 (en) | 2014-09-18 | 2022-07-05 | シーダーズ-サイナイ メディカル センター | Compositions and Methods for Treating Fibrosis |
AU2015317336B2 (en) | 2014-09-18 | 2021-01-21 | Tonix Pharma Holdings Limited | Eutectic formulations of Cyclobenzaprine hydrochloride |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
JP6625627B2 (en) | 2014-10-14 | 2019-12-25 | ハロザイム インコーポレイテッド | Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using the same |
EP3206708B1 (en) | 2014-10-16 | 2022-11-02 | Cleveland Biolabs, Inc. | Methods and compositions for the treatment of radiation-related disorders |
RS60737B1 (en) | 2014-10-21 | 2020-09-30 | Ariad Pharma Inc | Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl]pyrimidine-2,4-diamine |
US20170354639A1 (en) | 2014-10-24 | 2017-12-14 | Biogen Ma Inc. | Diterpenoid derivatives and methods of use thereof |
PT3215127T (en) | 2014-11-07 | 2021-02-10 | Sublimity Therapeutics Ltd | Compositions comprising cyclosporin |
TW201702218A (en) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | Compositions and methods relating to the treatment of cancer, autoimmune disease, and neurodegenerative disease |
BR112017012646A2 (en) | 2014-12-16 | 2018-01-02 | Celgene Corporation | SOLID FORMS UNDERSTANDING (1E, 4E) -2-AMINO- N, N-DIPROPIL-8- (4- (PIRROLIDIN-1-CARBONYL) PHENYL) -3H- BENZO [B] AZEPINE-4-CARBOXAMIDE, COMPOSITIONS OF THE SAME, AND USE OF THE SAME |
US9676793B2 (en) | 2014-12-23 | 2017-06-13 | Hoffmann-Laroche Inc. | Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same |
HUE049801T2 (en) | 2014-12-23 | 2020-10-28 | Sma Therapeutics Inc | 3,5-diaminopyrazole kinase inhibitors |
CN107530423B (en) | 2015-01-14 | 2022-04-05 | 布里格姆及妇女医院股份有限公司 | Treatment of cancer with anti-LAP monoclonal antibodies |
CA2974117A1 (en) | 2015-01-20 | 2016-07-28 | Xoc Pharmaceuticals, Inc. | Ergoline compounds and uses thereof |
JP2018502889A (en) | 2015-01-20 | 2018-02-01 | エックスオーシー ファーマシューティカルズ インコーポレイテッドXoc Pharmaceuticals, Inc | Isoergoline compounds and uses thereof |
US11497733B2 (en) | 2015-02-09 | 2022-11-15 | Synta Pharmaceuticals Corp. | Combination therapy of HSP90 inhibitors and PD-1 inhibitors for treating cancer |
CN107660207B (en) | 2015-03-10 | 2020-09-29 | 罗德科技公司 | Buprenorphine acetate and method for preparing buprenorphine |
TW201642857A (en) | 2015-04-06 | 2016-12-16 | 西建公司 | Treatment of hepatocellular carcinoma using combination therapy |
EP4194001A1 (en) | 2015-04-22 | 2023-06-14 | Cedars-Sinai Medical Center | Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes and obesity |
CN107922334B (en) | 2015-04-30 | 2021-11-23 | 科罗拉多大学董事会 | Polycyclic indoline and indolenine compounds |
CN108368147A (en) | 2015-05-27 | 2018-08-03 | 南方研究院 | Nucleotide for treating cancer |
EP3303286B1 (en) | 2015-06-01 | 2023-10-04 | Cedars-Sinai Medical Center | Compounds that bind to rela of nf-kb for use in treating cancer |
WO2016202721A1 (en) | 2015-06-16 | 2016-12-22 | F. Hoffmann-La Roche Ag | Salts of (s)-4-[(r)-6-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-3,6- dihydro-pyrimidin-4-ylmethyl]-morpholine-3-carboxylic acid, salt former and methods for preparing and using the same |
AU2016282790B9 (en) | 2015-06-23 | 2020-01-30 | Neurocrine Biosciences, Inc. | VMAT2 inhibitors for treating neurological diseases or disorders |
WO2016210262A1 (en) | 2015-06-26 | 2016-12-29 | Celgene Corporation | Methods for the treatment of kaposi's sarcoma or kshv-induced lymphoma using immunomodulatory compounds, and uses of biomarkers |
CA2991164A1 (en) | 2015-07-02 | 2017-01-05 | Celgene Corporation | Combination therapy for treatment of hematological cancers and solid tumors |
BR112018001441A2 (en) | 2015-07-28 | 2018-09-11 | Vyome Biosciences Pvt Ltd | therapeutic and prophylactic antibacterials |
WO2017023912A1 (en) | 2015-08-03 | 2017-02-09 | Temple University - Of The Commonwealth System Of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
HUE057306T2 (en) | 2015-08-17 | 2022-04-28 | Kura Oncology Inc | Methods of treating cancer patients with farnesyl transferase inhibitors |
JP2018530315A (en) | 2015-08-27 | 2018-10-18 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Compositions and methods for the treatment of pain |
CA2997947A1 (en) | 2015-09-09 | 2017-03-16 | The Trustees Of Columbia University In The City Of New York | Reduction of er-mam-localized app-c99 and methods of treating alzheimer's disease |
WO2017058828A1 (en) | 2015-09-28 | 2017-04-06 | Children's Hospital Los Angeles | Methods for treating diseases mediated by erbb4-positive pro-inflammatory macrophages |
WO2017059385A1 (en) | 2015-09-30 | 2017-04-06 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
RU2022102624A (en) | 2015-10-01 | 2022-03-10 | Хит Байолоджикс, Инк. | COMPOSITIONS AND METHODS FOR CONNECTING TYPE I AND TYPE II EXTRACELLULAR DOMAIN AS HETEROLOGOUS CHIMERIC PROTEINS |
WO2017069958A2 (en) | 2015-10-09 | 2017-04-27 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
US20180312534A1 (en) | 2015-10-16 | 2018-11-01 | Invictus Oncology Pvt. Ltd. | Fluorescent anticancer platinum drugs |
AU2016343633B2 (en) | 2015-10-30 | 2021-07-01 | Neurocrine Biosciences, Inc. | Valbenazine salts and polymorphs thereof |
WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
CA3003969A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
EP3373916A1 (en) | 2015-11-11 | 2018-09-19 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
US10112924B2 (en) | 2015-12-02 | 2018-10-30 | Astraea Therapeutics, Inc. | Piperdinyl nociceptin receptor compounds |
PT3394057T (en) | 2015-12-23 | 2022-04-21 | Neurocrine Biosciences Inc | Synthetic methods for preparation of (s)-(2r,3r,11br)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1h-pyrido[2,1,-a]lsoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) |
WO2017117118A1 (en) | 2015-12-28 | 2017-07-06 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
JP2019500397A (en) | 2015-12-31 | 2019-01-10 | クオナトウス ファーマシューティカルズ,インコーポレイテッド | Methods of using caspase inhibitors for the treatment of liver disease |
EP3399980A4 (en) | 2016-01-08 | 2019-09-04 | Celgene Corporation | Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies |
ES2957477T3 (en) | 2016-01-08 | 2024-01-19 | Celgene Corp | Antiproliferative compounds for use in the treatment of leukemia |
CN108712904B (en) | 2016-01-08 | 2022-08-02 | 细胞基因公司 | Solid forms of 2- (4-chlorophenyl) -N- ((2- (2, 6-dioxopiperidin-3-yl) -1-oxoisoindolin-5-yl) methyl) -2, 2-difluoroacetamide and pharmaceutical compositions and uses thereof |
JP6991979B2 (en) | 2016-02-05 | 2022-03-04 | オリオニス バイオサイエンシズ ビーブイ | CD8 binding substance |
JP2019507181A (en) | 2016-03-04 | 2019-03-14 | チャールストン ラボラトリーズ,インコーポレイテッド | Pharmaceutical composition |
US11248057B2 (en) | 2016-03-07 | 2022-02-15 | Vib Vzw | CD20 binding single domain antibodies |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
CN108884019A (en) | 2016-04-11 | 2018-11-23 | 克雷西奥生物科技有限公司 | Deuterated chloramines ketone derivatives |
US10047077B2 (en) | 2016-04-13 | 2018-08-14 | Skyline Antiinfectives, Inc. | Deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams |
US20190119758A1 (en) | 2016-04-22 | 2019-04-25 | Kura Oncology, Inc. | Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors |
WO2017190086A1 (en) | 2016-04-29 | 2017-11-02 | Fgh Biotech, Inc. | Di-substituted pyrazole compounds for the treatment of diseases |
JP2019514960A (en) | 2016-05-04 | 2019-06-06 | パーデュー ファーマ エルピー | Oxazoline pseudodimer, pharmaceutical composition and use thereof |
EP3454887B1 (en) | 2016-05-13 | 2021-01-20 | Orionis Biosciences BV | Targeted mutant interferon-beta and uses thereof |
CN109563141A (en) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | To the therapeutic targeting of cellular structures |
TWI753910B (en) | 2016-05-16 | 2022-02-01 | 美商拜歐斯瑞克斯公司 | Pyridinethiones, pharmaceutical compositions thereof, and their therapeutic use for treating a proliferative, inflammatory, neurodegenerative, or immune-mediated disease |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP3484475B1 (en) | 2016-07-18 | 2023-09-27 | Pharmena S.A. | 1-methylnicotinamide for the treatment of cardiovascular disease |
JOP20190008A1 (en) | 2016-07-26 | 2019-01-24 | Purdue Pharma Lp | Treatment and prevention of sleep disorders |
EP3490607A4 (en) | 2016-07-29 | 2020-04-08 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
EP3494119A4 (en) | 2016-07-29 | 2020-03-25 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
US10729670B2 (en) | 2016-09-07 | 2020-08-04 | Temple University—Of The Commonwealth Systems Of Higher Education | Compositions and methods for treatment of insulin resistance |
CN110072861B (en) | 2016-09-07 | 2022-11-11 | Fgh生物科技公司 | Disubstituted pyrazoles for the treatment of diseases |
FR3055800B1 (en) * | 2016-09-15 | 2020-06-26 | Unither Pharmaceuticals | SOLID COMPOSITION WITH FAST INGESTION AND EASY SWALLOWING, IN THE FORM OF NON-AGGLOMERATED SOLID PARTICLES, COMPRISING TWO DIFFERENT TYPES OF PARTICLES |
AU2017326558B2 (en) | 2016-09-19 | 2022-01-06 | Mei Pharma, Inc. | Combination therapy |
WO2018067991A1 (en) | 2016-10-07 | 2018-04-12 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
WO2018069312A1 (en) | 2016-10-11 | 2018-04-19 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Treatment of synucleinopathies |
WO2018071814A1 (en) | 2016-10-14 | 2018-04-19 | The Trustees Of Columbia University In The City Of New York | Methods of treating alcohol abuse disorder |
CN110072522A (en) | 2016-10-21 | 2019-07-30 | 美国大仁医疗有限公司 | Cancer cell is improved to the substance and method of the sensibility of cis-platinum |
CA3040802A1 (en) | 2016-10-24 | 2018-05-03 | Orionis Biosciences Nv | Targeted mutant interferon-gamma and uses thereof |
EA201991091A1 (en) | 2016-11-03 | 2019-11-29 | WAYS OF TREATMENT OF PATIENTS WITH MALIGNANT NEW FORMATIONS USING PHARNESYL TRANSFERASE INHIBITORS | |
US10106521B2 (en) | 2016-11-09 | 2018-10-23 | Phloronol, Inc. | Eckol derivatives, methods of synthesis and uses thereof |
US10988442B2 (en) | 2016-11-09 | 2021-04-27 | Novomedix, Llc | Nitrite salts of 1,1-dimethylbiguanide, pharmaceutical compositions, and methods of use |
EP3548007A4 (en) | 2016-12-01 | 2020-08-12 | Ignyta, Inc. | Methods for the treatment of cancer |
US20200078352A1 (en) | 2016-12-02 | 2020-03-12 | Neurocrine Biosciences, Inc. | Use of Valbenazine for Treating Schizophrenia or Schizoaffective Disorder |
WO2018140671A1 (en) | 2017-01-27 | 2018-08-02 | Celgene Corporation | 3-(1-oxo-4-((4-((3-oxomorpholino) methyl)benzyl)oxy)isoindolin-2-yl)piperidine-2,6-dione and isotopologues thereof |
WO2018140092A1 (en) | 2017-01-27 | 2018-08-02 | Obrien Christopher F | Methods for the administration of certain vmat2 inhibitors |
US10889587B2 (en) | 2017-02-06 | 2021-01-12 | Spero Therapeutics, Inc. | Tebipenem pivoxil crystalline forms, compositions including the same, methods of manufacture, and methods of use |
MX2019009255A (en) | 2017-02-06 | 2019-11-05 | Orionis Biosciences Nv | Targeted chimeric proteins and uses thereof. |
WO2018144999A1 (en) | 2017-02-06 | 2018-08-09 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
US11246911B2 (en) | 2017-02-07 | 2022-02-15 | Vib Vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
WO2018151861A1 (en) | 2017-02-16 | 2018-08-23 | Sunovion Pharamaceuticials Inc. | Methods of treating schizophrenia |
US9956215B1 (en) | 2017-02-21 | 2018-05-01 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
CN114796218A (en) | 2017-02-21 | 2022-07-29 | 库拉肿瘤学公司 | Methods of treating cancer using farnesyl transferase inhibitors |
US11192933B2 (en) | 2017-02-27 | 2021-12-07 | Shattuck Labs, Inc. | VSIG8-based chimeric proteins |
WO2018164996A1 (en) | 2017-03-06 | 2018-09-13 | Neurocrine Biosciences, Inc. | Dosing regimen for valbenazine |
WO2018165142A1 (en) | 2017-03-07 | 2018-09-13 | Celgene Corporation | Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses |
EP3601326A4 (en) | 2017-03-20 | 2020-12-16 | The Broad Institute, Inc. | Compounds and methods for regulating insulin secretion |
CA3050086A1 (en) | 2017-03-26 | 2018-10-04 | Mapi Pharma Ltd. | Glatiramer depot systems for treating progressive forms of multiple sclerosis |
CN110831945B (en) | 2017-03-29 | 2023-08-08 | 赛特温治疗公司 | 11, 13-modified saxitoxins for the treatment of pain |
WO2018183782A1 (en) | 2017-03-29 | 2018-10-04 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
WO2018200605A1 (en) | 2017-04-26 | 2018-11-01 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
JOP20190219A1 (en) | 2017-05-09 | 2019-09-22 | Cardix Therapeutics LLC | Pharmaceutical compositions and methods of treating cardiovascular diseases |
US10085999B1 (en) | 2017-05-10 | 2018-10-02 | Arixa Pharmaceuticals, Inc. | Beta-lactamase inhibitors and uses thereof |
ES2913213T3 (en) | 2017-05-19 | 2022-06-01 | Nflection Therapeutics Inc | Condensed Aniline Heteroaromatic Compounds for the Treatment of Skin Disorders |
MX2019013561A (en) | 2017-05-19 | 2022-02-09 | Nflection Therapeutics Inc | Pyrrolopyridine-aniline compounds for treatment of dermal disorders. |
EP3630079A4 (en) | 2017-05-31 | 2021-02-24 | The Children's Medical Center Corporation | TARGETING LYSINE DEMETHYLASES (KDMs) AS A THERAPEUTIC STRATEGY FOR DIFFUSE LARGE B-CELL LYMPHOMA |
CA3064274A1 (en) | 2017-06-01 | 2018-12-06 | Xoc Pharmaceuticals, Inc. | Ergoline derivatives for use in medicine |
WO2019005874A1 (en) | 2017-06-26 | 2019-01-03 | The Trustees Of Columbia University In The City Of New York | Cholinergic agonism for the treatment of pancreatic cancer |
WO2019014398A1 (en) | 2017-07-11 | 2019-01-17 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
CN110996932A (en) | 2017-07-13 | 2020-04-10 | 托尼克斯医药控股公司 | Cyclobenzaprine and amitriptyline analogs |
CA3069462A1 (en) | 2017-07-16 | 2019-01-24 | Neuere, Llc | Ambroxol to improve and/or extend healthspan, lifespan and/or mental acuity |
EP3661929B1 (en) | 2017-08-02 | 2021-07-14 | Sunovion Pharmaceuticals Inc. | Isochroman compounds and uses thereof |
US10806730B2 (en) | 2017-08-07 | 2020-10-20 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
SG11202000894TA (en) | 2017-08-07 | 2020-02-27 | Kura Oncology Inc | Methods of treating cancer with farnesyltransferase inhibitors |
AU2018335259A1 (en) | 2017-09-21 | 2020-04-09 | Neurocrine Biosciences, Inc. | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
CA3077474A1 (en) | 2017-10-02 | 2019-04-11 | Arixa Pharmaceuticals, Inc. | Aztreonam derivatives and uses thereof |
US10993941B2 (en) | 2017-10-10 | 2021-05-04 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
AU2017435893B2 (en) | 2017-10-10 | 2023-06-29 | Neurocrine Biosciences, Inc | Methods for the administration of certain VMAT2 inhibitors |
EP3713916A1 (en) | 2017-11-20 | 2020-09-30 | Kiakos, Konstantinos | 3,5-diarylidenyl-n-substituted-piperid-4-one-derived inhibitors of stat3 pathway acitivty and uses therof |
WO2019113269A1 (en) | 2017-12-08 | 2019-06-13 | Kura Oncology, Inc. | Methods of treating cancer patients with farnesyltransferase inhibitors |
US11826321B2 (en) | 2017-12-11 | 2023-11-28 | Tonix Pharma Holdings Limited | Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions |
WO2019118984A2 (en) | 2017-12-15 | 2019-06-20 | Solarea Bio, Inc. | Microbial compositions and methods for treating type 2 diabetes, obesity, and metabolic syndrome |
WO2019126136A2 (en) | 2017-12-18 | 2019-06-27 | Sterngreene, Inc. | Pyrimidine compounds useful as tyrosine kinase inhibitors |
WO2019136314A1 (en) | 2018-01-05 | 2019-07-11 | The Curators Of The University Of Missouri | Compounds and methods for treatment of cystic fibrosis |
WO2019139869A1 (en) | 2018-01-10 | 2019-07-18 | Cura Therapeutics Llc | Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications |
TW201929847A (en) | 2018-01-10 | 2019-08-01 | 美商克拉治療有限責任公司 | Pharmaceutical compositions comprising dicarboxylic acids and their therapeutic applications |
KR20200103045A (en) | 2018-01-24 | 2020-09-01 | 퍼듀 퍼머 엘피 | Sleep disorder treatment and prevention |
EP3749295A4 (en) | 2018-02-05 | 2022-04-27 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
KR20200141986A (en) | 2018-02-12 | 2020-12-21 | 다이어비티스-프리, 인크. | Improved antagonistic anti-human CD40 monoclonal antibody |
US20210008030A1 (en) | 2018-02-16 | 2021-01-14 | Sunovion Pharmaceuticals Inc. | Methods of treating social function disorders |
KR20200138714A (en) | 2018-02-21 | 2020-12-10 | 에이아이 테라퓨틱스, 인코포레이티드 | Combination therapy with apilimod and glutamate agents |
US20210015899A1 (en) | 2018-03-22 | 2021-01-21 | The Children's Medical Center Corporation | Methods and compositions relating to lung repair |
US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
WO2019241555A1 (en) | 2018-06-14 | 2019-12-19 | Neurocrine Biosciences, Inc. | Vmat2 inhibitor compounds, compositions, and methods relating thereto |
US11447497B2 (en) | 2018-06-29 | 2022-09-20 | Histogen, Inc. | (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
CA3106143A1 (en) | 2018-07-11 | 2020-01-16 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
AU2019322863A1 (en) | 2018-08-15 | 2021-03-11 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
WO2020047161A2 (en) | 2018-08-28 | 2020-03-05 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
JP2022511286A (en) | 2018-08-29 | 2022-01-31 | シャタック ラボ,インコーポレイテッド | Combination therapy with SIRP alpha chimeric proteins |
CA3111795A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
US11180500B2 (en) | 2018-10-01 | 2021-11-23 | Arixa Pharmaceuticals, Inc. | Derivatives of relebactam and uses thereof |
EP3860714B1 (en) | 2018-10-03 | 2023-09-06 | Siteone Therapeutics, Inc. | 11,13-modified saxitoxins for the treatment of pain |
SG11202104296TA (en) | 2018-11-01 | 2021-05-28 | Kura Oncology Inc | Methods of treating cancer with farnesyltransferase inhibitors |
WO2020102454A1 (en) | 2018-11-13 | 2020-05-22 | Regents Of The University Of Minnesota | Cd40 targeted peptides and uses thereof |
JP7406264B2 (en) | 2018-11-20 | 2023-12-27 | エヌフレクション セラピューティクス インコーポレイテッド | Cyanoaryl-aniline compounds for the treatment of skin disorders |
MA55144A (en) | 2018-11-20 | 2021-09-29 | Nflection Therapeutics Inc | NAPHTHYRIDINONE-ANILINE COMPOUNDS FOR THE TREATMENT OF SKIN CONDITIONS |
EP4233865A3 (en) | 2018-11-20 | 2023-09-27 | NFlection Therapeutics, Inc. | Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers |
CN113645964A (en) | 2018-11-20 | 2021-11-12 | 恩福莱克逊治疗有限公司 | Arylaniline and heteroarylaniline compounds for use in fetal marker therapy |
US20230078755A1 (en) | 2018-12-19 | 2023-03-16 | Shy Therapeutics, Llc | Compounds that Interact with the RAS Superfamily for the Treatment of Cancers, Inflammatory Diseases, Rasopathies, and Fibrotic Disease |
WO2020132700A1 (en) | 2018-12-21 | 2020-06-25 | Fgh Biotech Inc. | Methods of using inhibitors of srebp in combination with niclosamide and analogs thereof |
US20220071941A1 (en) | 2018-12-21 | 2022-03-10 | Kura Oncology, Inc. | Therapies for squamous cell carcinomas |
CN113874080A (en) | 2019-02-06 | 2021-12-31 | 戴斯阿尔法公司 | IL-17A modulators and uses thereof |
CN113748124A (en) | 2019-02-27 | 2021-12-03 | 阿克蒂姆治疗有限公司 | Immunostimulatory bacteria engineered to colonize tumors, tumor resident immune cells, and tumor microenvironment |
WO2020180663A1 (en) | 2019-03-01 | 2020-09-10 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
JP2022524049A (en) | 2019-03-07 | 2022-04-27 | クオナトウス ファーマシューティカルズ,インコーポレイテッド | Caspase inhibitors and how to use them |
SG11202108905UA (en) | 2019-03-12 | 2021-09-29 | Arixa Pharmaceuticals Inc | Crystalline form of an avibactam derivative |
CA3130849A1 (en) | 2019-03-14 | 2020-09-17 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
US20220143006A1 (en) | 2019-03-15 | 2022-05-12 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
WO2020193431A1 (en) | 2019-03-22 | 2020-10-01 | Deutsches Krebsforschungszentrum | Novel inhibitors of histone deacetylase 10 |
EP3712127A1 (en) | 2019-03-22 | 2020-09-23 | Deutsches Krebsforschungszentrum | Novel inhibitors of histone deacetylase 10 |
CA3134825A1 (en) | 2019-03-29 | 2020-10-08 | Kura Oncology, Inc. | Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors |
WO2020205387A1 (en) | 2019-04-01 | 2020-10-08 | Kura Oncology, Inc. | Methods of treating cancer with farnesyltransferase inhibitors |
JP2022527825A (en) | 2019-04-03 | 2022-06-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Ionic liquids for drug delivery |
WO2020219258A1 (en) | 2019-04-25 | 2020-10-29 | Arixa Pharmaceuticals, Inc. | Methods of synthesizing aztreonam derivatives |
US20220305001A1 (en) | 2019-05-02 | 2022-09-29 | Kura Oncology, Inc. | Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors |
WO2020227437A1 (en) | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
CN113874375A (en) | 2019-06-03 | 2021-12-31 | 株式会社大分大学先端医学研究所 | Cyclic amide compounds and methods thereof for the treatment of rabies |
EP3986163A2 (en) | 2019-06-19 | 2022-04-27 | Solarea Bio, Inc. | Microbial compositions and methods for producing upgraded probiotic assemblages |
US20220274922A1 (en) | 2019-07-11 | 2022-09-01 | Cura Therapeutics, Llc | Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications |
CA3146159A1 (en) | 2019-07-11 | 2021-01-14 | Cura Therapeutics, Llc | Phenyl compounds and pharmaceutical compositions thereof, and their therapeutic applications |
EP4003314A4 (en) | 2019-07-26 | 2023-09-20 | Espervita Therapeutics, Inc. | Functionalized long-chain hydrocarbon mono- and di-carboxylic acids useful for the prevention or treatment of disease |
US10792262B1 (en) | 2019-07-29 | 2020-10-06 | Saol International Limited | Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives |
US11654124B2 (en) | 2019-07-29 | 2023-05-23 | Amneal Pharmaceuticals Llc | Stabilized formulations of 4-amino-3-substituted butanoic acid derivatives |
US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
CN115551530A (en) | 2019-08-27 | 2022-12-30 | 通尼克斯制药有限公司 | Modified TFF2 polypeptides |
IL291345B2 (en) | 2019-09-16 | 2024-04-01 | Dice Alpha Inc | Il-17a modulators and uses thereof |
WO2021059023A1 (en) | 2019-09-26 | 2021-04-01 | Abionyx Pharma Sa | Compounds useful for treating liver diseases |
KR20220091488A (en) | 2019-10-01 | 2022-06-30 | 몰레큘러 스킨 테라퓨틱스, 인코포레이티드 | Benzoxazinone Compounds as KLK5/7 Dual Inhibitors |
IL292836A (en) | 2019-11-12 | 2022-07-01 | Actym Therapeutics Inc | Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0169581A2 (en) * | 1984-07-27 | 1986-01-29 | BOEHRINGER BIOCHEMIA ROBIN S.p.A. | Antitussive and mucus regulating 2-substituted thiazolidines |
EP0359195A2 (en) * | 1988-09-16 | 1990-03-21 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Controlled release therapeutic system for liquid pharmaceutical formulations |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1216119B (en) * | 1988-03-17 | 1990-02-22 | Boehringer Biochemia Srl | BETA_CARBONIL_CARBOSSIAMIDI DI 1,3_TIAZOLIDINE. |
US5296236A (en) * | 1988-09-16 | 1994-03-22 | Recordati S.A., Chemical And Pharmaceutical Company | Controlled release therapeutic system for a liquid pharmaceutical formulations |
IT1264020B (en) * | 1993-01-28 | 1996-09-09 | Recordati Chem Pharm | PROCEDURE FOR THE PREPARATION OF MICROGRANULES SUITABLE FOR SUSPENSION IN LIQUIDS |
-
1994
- 1994-07-07 IT ITMI941410A patent/IT1270594B/en active IP Right Grant
-
1995
- 1995-05-26 US US08/452,435 patent/US5674533A/en not_active Expired - Fee Related
- 1995-05-29 MX MX9700223A patent/MX9700223A/en unknown
- 1995-05-29 HU HU9700017A patent/HUT76832A/en active IP Right Revival
- 1995-05-29 EP EP95918125A patent/EP0769948A1/en not_active Ceased
- 1995-05-29 CZ CZ199750A patent/CZ287967B6/en not_active IP Right Cessation
- 1995-05-29 CA CA002194374A patent/CA2194374A1/en not_active Abandoned
- 1995-05-29 AU AU24176/95A patent/AU2417695A/en not_active Abandoned
- 1995-05-29 KR KR1019970700062A patent/KR970704437A/en not_active Application Discontinuation
- 1995-05-29 WO PCT/IB1995/000412 patent/WO1996001628A1/en not_active Application Discontinuation
- 1995-05-29 BR BR9510302A patent/BR9510302A/en not_active Application Discontinuation
- 1995-05-29 JP JP8504206A patent/JPH10502629A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0169581A2 (en) * | 1984-07-27 | 1986-01-29 | BOEHRINGER BIOCHEMIA ROBIN S.p.A. | Antitussive and mucus regulating 2-substituted thiazolidines |
EP0359195A2 (en) * | 1988-09-16 | 1990-03-21 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Controlled release therapeutic system for liquid pharmaceutical formulations |
Non-Patent Citations (2)
Title |
---|
CHEMICAL ABSTRACTS, vol. 121, no. 7, 15 August 1994, Columbus, Ohio, US; abstract no. 73498 * |
L. GALLICO ET AL.: "MOGUISTEINE:A NOVEL PERIPHERAL NON-NARCOTIC ANTITUSSIVE DRUG.", BR. J. PHARMACOL., vol. 112, no. 3, 1994, pages 795 - 800 * |
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US5900258A (en) * | 1996-02-01 | 1999-05-04 | Zeolitics Inc. | Anti-bacterial compositions |
WO1998036732A2 (en) * | 1997-02-21 | 1998-08-27 | Lindopharm Gmbh | Combination preparation for orally administered antibiotics |
WO1998036732A3 (en) * | 1997-02-21 | 1998-10-22 | Glf Galenik Labor Gmbh | Combination preparation for orally administered antibiotics |
US6794411B1 (en) | 1999-04-06 | 2004-09-21 | Laboratoire Des Produits Ethiques Ethypharm | Drinkable ibuprofen pharmaceutical suspension |
WO2003084517A2 (en) | 2002-04-09 | 2003-10-16 | Flamel Technologies | Oral suspension of amoxicillin capsules |
US9814684B2 (en) | 2002-04-09 | 2017-11-14 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
US10004693B2 (en) | 2002-04-09 | 2018-06-26 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
FR2843881A1 (en) * | 2002-09-02 | 2004-03-05 | Flamel Tech Sa | Oral aqueous suspension of microencapsulated drug, e.g. acyclovir or metformin, with specific polymer based, release-controlling film coating ensuring consistent release profile after storage |
US9668993B2 (en) | 2003-03-21 | 2017-06-06 | Johnson & Johnson Consumer Inc. | Non-steroidal anti-inflammatory drug dosing regimen |
FR2911506A1 (en) * | 2007-01-18 | 2008-07-25 | Ceva Sante Animale Sa | PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION IN THE FORM OF STABILIZED AQUEOUS SUSPENSIONS |
US8999395B2 (en) | 2007-02-09 | 2015-04-07 | Ceva Sante Animale | Pharmaceutical compositions for oral administration in the form of stabilised aqueous suspensions |
Also Published As
Publication number | Publication date |
---|---|
US5674533A (en) | 1997-10-07 |
ITMI941410A0 (en) | 1994-07-07 |
KR970704437A (en) | 1997-09-06 |
CZ5097A3 (en) | 1997-09-17 |
HU9700017D0 (en) | 1997-02-28 |
CA2194374A1 (en) | 1996-01-25 |
IT1270594B (en) | 1997-05-07 |
EP0769948A1 (en) | 1997-05-02 |
CZ287967B6 (en) | 2001-03-14 |
AU2417695A (en) | 1996-02-09 |
HUT76832A (en) | 1997-11-28 |
JPH10502629A (en) | 1998-03-10 |
BR9510302A (en) | 1997-11-11 |
ITMI941410A1 (en) | 1996-01-07 |
MX9700223A (en) | 1997-04-30 |
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