WO1995031479A1 - Methods and compositions for the dry powder formulation of interferons - Google Patents
Methods and compositions for the dry powder formulation of interferons Download PDFInfo
- Publication number
- WO1995031479A1 WO1995031479A1 PCT/US1995/006008 US9506008W WO9531479A1 WO 1995031479 A1 WO1995031479 A1 WO 1995031479A1 US 9506008 W US9506008 W US 9506008W WO 9531479 A1 WO9531479 A1 WO 9531479A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- interferon
- dry powder
- spray
- carrier
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT95919181T ATE299892T1 (en) | 1994-05-18 | 1995-05-15 | METHODS AND COMPOSITIONS FOR DRY POWDER MEDICATION FROM INTERFERONS |
JP7529809A JPH10500672A (en) | 1994-05-18 | 1995-05-15 | Methods and compositions relating to dry powder formulations of interferon |
NZ285664A NZ285664A (en) | 1994-05-18 | 1995-05-15 | Dry powder interferon composition adapted for pulmonary delivery |
EP95919181A EP0759939B1 (en) | 1994-05-18 | 1995-05-15 | Methods and compositions for the dry powder formulation of interferons |
DE69534318T DE69534318T2 (en) | 1994-05-18 | 1995-05-15 | METHODS AND COMPOSITIONS FOR THE DRY PLANT FROM INTERFERONS |
MX9605717A MX9605717A (en) | 1994-05-18 | 1995-05-15 | Methods and compositions for the dry powder formulation of interferons. |
AU25142/95A AU696387B2 (en) | 1994-05-18 | 1995-05-15 | Methods and compositions for the dry powder formulation of interferons |
US08/737,724 US6231851B1 (en) | 1994-05-18 | 1995-05-15 | Methods and compositions for the dry powder formulation of interferons |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24603494A | 1994-05-18 | 1994-05-18 | |
US08/246,034 | 1994-05-18 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US24603494A Continuation-In-Part | 1992-07-08 | 1994-05-18 |
Related Child Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/423,515 Continuation-In-Part US6582728B1 (en) | 1992-07-08 | 1995-04-14 | Spray drying of macromolecules to produce inhaleable dry powders |
US08/737,724 A-371-Of-International US6231851B1 (en) | 1992-07-08 | 1995-05-15 | Methods and compositions for the dry powder formulation of interferons |
US09/444,116 Continuation US6123936A (en) | 1994-05-18 | 1999-11-22 | Methods and compositions for the dry powder formulation of interferons |
US09/447,753 Continuation US6372258B1 (en) | 1992-07-08 | 1999-11-22 | Methods of spray-drying a drug and a hydrophobic amino acid |
US09/506,426 Continuation US6479049B1 (en) | 1994-05-18 | 2000-02-17 | Methods and compositions for the dry powder formulation of interferons |
US09/616,236 Continuation-In-Part US6673335B1 (en) | 1992-07-08 | 2000-07-14 | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995031479A1 true WO1995031479A1 (en) | 1995-11-23 |
Family
ID=22929067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/006008 WO1995031479A1 (en) | 1994-05-18 | 1995-05-15 | Methods and compositions for the dry powder formulation of interferons |
Country Status (13)
Country | Link |
---|---|
US (4) | US6231851B1 (en) |
EP (1) | EP0759939B1 (en) |
JP (1) | JPH10500672A (en) |
KR (1) | KR100384353B1 (en) |
CN (1) | CN1073119C (en) |
AT (1) | ATE299892T1 (en) |
AU (1) | AU696387B2 (en) |
CA (1) | CA2190502A1 (en) |
DE (1) | DE69534318T2 (en) |
ES (1) | ES2245780T3 (en) |
MX (1) | MX9605717A (en) |
NZ (1) | NZ285664A (en) |
WO (1) | WO1995031479A1 (en) |
Cited By (45)
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WO1997018830A1 (en) * | 1995-11-17 | 1997-05-29 | Schering Aktiengesellschaft | USE OF INTERFERON-β FOR TREATING BRONCHIAL CARCINOMA DURING RADIATION THERAPY |
WO1997036578A1 (en) * | 1996-04-03 | 1997-10-09 | Andaris Limited | Spray-dried microparticles as therapeutic vehicles for use in gene therapy |
WO1997044015A1 (en) * | 1996-05-17 | 1997-11-27 | Andaris Limited | Microparticles and their use in wound therapy |
EP0820277A1 (en) * | 1995-04-14 | 1998-01-28 | Inhale Therapeutic Systems | Powdered pharmaceutical formulations having improved dispersibility |
WO1998016205A2 (en) * | 1996-10-17 | 1998-04-23 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
US5955108A (en) * | 1994-12-16 | 1999-09-21 | Quadrant Healthcare (Uk) Limited | Cross-linked microparticles and their use as therapeutic vehicles |
US6153211A (en) * | 1997-07-18 | 2000-11-28 | Infimed, Inc. | Biodegradable macromers for the controlled release of biologically active substances |
US6284282B1 (en) | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
EP1254944A1 (en) * | 1999-12-24 | 2002-11-06 | Otsuka Pharmaceutical Co., Ltd. | Dry compositions containing hydrophobic amino acid |
WO2002102445A1 (en) | 2001-06-15 | 2002-12-27 | Otsuka Pharmaceutical Co., Ltd. | Dry powder inhalation system for transpulmonary administration |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
EP1424066A1 (en) * | 1995-12-25 | 2004-06-02 | Otsuka Pharmaceutical Co., Ltd. | Dry compositions comprising hydrophobic stabilisers |
WO2004054605A1 (en) * | 2002-12-13 | 2004-07-01 | Otsuka Pharmaceutical Co., Ltd. | Freeze-dried interferon-ϝ composition for transpulmonary administration and inhalation system therefor |
US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
US6994847B2 (en) | 2000-11-07 | 2006-02-07 | Chiron Corporation | Stabilized interferon compositions |
US7172999B2 (en) | 1995-10-25 | 2007-02-06 | Roche Diagnostics Gmbh | Method and preparations for stabilizing biological materials by drying methods without freezing |
EP1351704B1 (en) * | 2000-12-21 | 2007-03-07 | Nektar Therapeutics | Storage stable powder compositions of interleukin-4 receptor |
WO2008000780A2 (en) * | 2006-06-29 | 2008-01-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalant powder containing phenylalanine |
US7326691B2 (en) | 2004-06-21 | 2008-02-05 | Nektar Therapeutics | Compositions comprising amphotericin B, methods, and systems |
US7544354B2 (en) | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
US7611709B2 (en) | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
US7727962B2 (en) | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
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US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
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Also Published As
Publication number | Publication date |
---|---|
CN1073119C (en) | 2001-10-17 |
EP0759939A1 (en) | 1997-03-05 |
US6123936A (en) | 2000-09-26 |
KR100384353B1 (en) | 2003-10-04 |
AU696387B2 (en) | 1998-09-10 |
CA2190502A1 (en) | 1995-11-23 |
US20030072718A1 (en) | 2003-04-17 |
ES2245780T3 (en) | 2006-01-16 |
KR970703366A (en) | 1997-07-03 |
NZ285664A (en) | 1998-07-28 |
US6231851B1 (en) | 2001-05-15 |
AU2514295A (en) | 1995-12-05 |
US6479049B1 (en) | 2002-11-12 |
ATE299892T1 (en) | 2005-08-15 |
MX9605717A (en) | 1998-05-31 |
CN1151168A (en) | 1997-06-04 |
DE69534318T2 (en) | 2006-04-20 |
DE69534318D1 (en) | 2005-08-25 |
EP0759939B1 (en) | 2005-07-20 |
JPH10500672A (en) | 1998-01-20 |
EP0759939A4 (en) | 1998-05-27 |
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