WO1995022749A3 - Automated cytological specimen classification system and method - Google Patents

Automated cytological specimen classification system and method Download PDF

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Publication number
WO1995022749A3
WO1995022749A3 PCT/US1995/000853 US9500853W WO9522749A3 WO 1995022749 A3 WO1995022749 A3 WO 1995022749A3 US 9500853 W US9500853 W US 9500853W WO 9522749 A3 WO9522749 A3 WO 9522749A3
Authority
WO
WIPO (PCT)
Prior art keywords
specimen
classification system
cytological specimen
objects
premalignant
Prior art date
Application number
PCT/US1995/000853
Other languages
French (fr)
Other versions
WO1995022749A2 (en
Inventor
Mark R Rutenberg
Akiva Rutenberg
Lanbrecht Piet Kok
Mathilde Elisabeth Boon
Laurie J Mango
Original Assignee
Neuromedical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuromedical Systems Inc filed Critical Neuromedical Systems Inc
Priority to AT95908098T priority Critical patent/ATE256313T1/en
Priority to EP95908098A priority patent/EP0745243B9/en
Priority to AU16057/95A priority patent/AU691568B2/en
Priority to DE69532276T priority patent/DE69532276T2/en
Priority to CA002182793A priority patent/CA2182793C/en
Priority to DK95908098T priority patent/DK0745243T3/en
Priority to JP7521802A priority patent/JPH09509487A/en
Publication of WO1995022749A2 publication Critical patent/WO1995022749A2/en
Publication of WO1995022749A3 publication Critical patent/WO1995022749A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/02—Details not specific for a particular testing method
    • G01N2203/06—Indicating or recording means; Sensing means
    • G01N2203/0641—Indicating or recording means; Sensing means using optical, X-ray, ultraviolet, infrared or similar detectors
    • G01N2203/0647—Image analysis

Abstract

A semi-automated method of classifying a specimen for the presence of premalignant or malignant cells, including the steps of treating a specimen with an immunochemical marker to provide a visual indication of cell proliferation, ranking individual objects in the specimen in an order according to the likelihood that each object has attributes consistent with a premalignant or malignant cell or cell cluster, selecting for display a set of said objects according to said ranking, and displaying images of said selected objects to facilitate review by an operator.
PCT/US1995/000853 1994-02-14 1995-01-23 Automated cytological specimen classification system and method WO1995022749A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT95908098T ATE256313T1 (en) 1994-02-14 1995-01-23 AUTOMATED CYTOLOGICAL SAMPLE CLASSIFICATION METHOD
EP95908098A EP0745243B9 (en) 1994-02-14 1995-01-23 Automated cytological specimen classification methods
AU16057/95A AU691568B2 (en) 1994-02-14 1995-01-23 Automated cytological specimen classification system and method
DE69532276T DE69532276T2 (en) 1994-02-14 1995-01-23 AUTOMATED CYTOLOGICAL SAMPLING CLASSIFICATION METHOD
CA002182793A CA2182793C (en) 1994-02-14 1995-01-23 Automated cytological specimen classification system and method
DK95908098T DK0745243T3 (en) 1994-02-14 1995-01-23 Methods for automated classification of cytological specimens
JP7521802A JPH09509487A (en) 1994-02-14 1995-01-23 Cell sample automatic classification device and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19671494A 1994-02-14 1994-02-14
US08/196,714 1994-02-14

Publications (2)

Publication Number Publication Date
WO1995022749A2 WO1995022749A2 (en) 1995-08-24
WO1995022749A3 true WO1995022749A3 (en) 1995-09-14

Family

ID=22726553

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/000853 WO1995022749A2 (en) 1994-02-14 1995-01-23 Automated cytological specimen classification system and method

Country Status (9)

Country Link
EP (1) EP0745243B9 (en)
JP (1) JPH09509487A (en)
CN (1) CN1140498A (en)
AT (1) ATE256313T1 (en)
AU (1) AU691568B2 (en)
DE (1) DE69532276T2 (en)
DK (1) DK0745243T3 (en)
ES (1) ES2213750T3 (en)
WO (1) WO1995022749A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6091842A (en) * 1996-10-25 2000-07-18 Accumed International, Inc. Cytological specimen analysis system with slide mapping and generation of viewing path information
US6430309B1 (en) 1995-09-15 2002-08-06 Monogen, Inc. Specimen preview and inspection system
US6148096A (en) * 1995-09-15 2000-11-14 Accumed International, Inc. Specimen preview and inspection system
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
US6651008B1 (en) 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics
US6876760B1 (en) * 2000-12-04 2005-04-05 Cytokinetics, Inc. Classifying cells based on information contained in cell images
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
US6535626B1 (en) 2000-01-14 2003-03-18 Accumed International, Inc. Inspection system with specimen preview
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
GB2406908B (en) * 2000-12-04 2005-07-27 Cytokinetics Inc Classifying cells based on information contained in cell images
US6599694B2 (en) 2000-12-18 2003-07-29 Cytokinetics, Inc. Method of characterizing potential therapeutics by determining cell-cell interactions
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
JP4259802B2 (en) * 2002-02-19 2009-04-30 日本分光株式会社 Abnormal part and degree of abnormality identification method in cancer diagnosis
EP1646926A2 (en) 2003-07-18 2006-04-19 Cytokinetics, Inc. Characterizing biological stimuli by response curves
US20050014217A1 (en) 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7235353B2 (en) 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
ATE520988T1 (en) * 2004-09-22 2011-09-15 Tripath Imaging Inc METHODS AND COMPOSITIONS FOR EVALUATION OF BREAST CANCER PROGNOSIS
HUP0600177A2 (en) * 2006-03-03 2009-03-02 3D Histech Kft Equipment for and method of digitizing slides by automated digital image recording system
JP5438962B2 (en) * 2008-12-25 2014-03-12 シスメックス株式会社 Cell image display device
WO2013076099A1 (en) 2011-11-24 2013-05-30 Bayer Intellectual Property Gmbh Production and use of high-molecular-weight aliphatic polycarbonates
US20200005014A1 (en) * 2017-01-05 2020-01-02 Konica Minolta, Inc. Non-transitory computer-readable recording medium storing image analysis program and image analysis method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965725A (en) * 1988-04-08 1990-10-23 Nueromedical Systems, Inc. Neural network based automated cytological specimen classification system and method
US5235522A (en) * 1990-10-10 1993-08-10 Cell Analysis Systems, Inc. Method and apparatus for automated analysis of biological specimens
US5257182A (en) * 1991-01-29 1993-10-26 Neuromedical Systems, Inc. Morphological classification system and method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086476A (en) * 1985-11-04 1992-02-04 Cell Analysis Systems, Inc. Method and apparatus for determining a proliferation index of a cell sample
EP0479977B1 (en) * 1990-03-30 1997-07-16 Neuromedical Systems, Inc Automated cytological specimen classification system and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965725A (en) * 1988-04-08 1990-10-23 Nueromedical Systems, Inc. Neural network based automated cytological specimen classification system and method
US4965725B1 (en) * 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
US5235522A (en) * 1990-10-10 1993-08-10 Cell Analysis Systems, Inc. Method and apparatus for automated analysis of biological specimens
US5257182A (en) * 1991-01-29 1993-10-26 Neuromedical Systems, Inc. Morphological classification system and method
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ACTA CYTOLOGICA: THE JOURNAL OF CLINICAL CYTOLOGY AND CYTOPATHOLOGY, Volume 32, No. 2, issued 04 April 1988, F.M. GAVIN et al., "Morphometric Differences Between Cytologically Benign and Malignant Serous Effusions", pages 175-182. *
ANALYTICAL AND QUATITATIVE CYTOLOGY AND HISTOLOGY, Volume 13, No. 1, issued February 1991, M.S. WACHTEL et al., "Automated Analysis of Rat Breast Tumors", pages 69-73. *
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Volume 41, No. 9, issued 22 September 1994, F. ERCAL et al., "Neural Network Diagnosis of Malignant Melanoma from Color Images", pages 837-645. *
MDDI REPORTS GRAY SHEET, issued 23 September 1991, "NeoPath AutoPap 300 Designed to Analyze Pap Smears without Cytologist", page 16. *
PROCEEDINGS OF THE NINTH ANNUAL CONFERENCE OF THE ENGINEERING IN MEDICINE AND BIOLOGICAL SOCIETY, issued 04 December 1987, D. TIEN et al., "Automated Cervical Smear Classification", pages 1-2. *

Also Published As

Publication number Publication date
EP0745243B1 (en) 2003-12-10
DE69532276D1 (en) 2004-01-22
DK0745243T3 (en) 2004-04-19
ATE256313T1 (en) 2003-12-15
EP0745243A4 (en) 2000-12-27
EP0745243B9 (en) 2008-01-02
JPH09509487A (en) 1997-09-22
AU1605795A (en) 1995-09-04
WO1995022749A2 (en) 1995-08-24
ES2213750T3 (en) 2004-09-01
EP0745243A1 (en) 1996-12-04
CN1140498A (en) 1997-01-15
DE69532276T2 (en) 2005-02-10
AU691568B2 (en) 1998-05-21

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