WO1995003328A3 - Melanom-inhibierendes protein - Google Patents

Melanom-inhibierendes protein Download PDF

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Publication number
WO1995003328A3
WO1995003328A3 PCT/EP1994/002369 EP9402369W WO9503328A3 WO 1995003328 A3 WO1995003328 A3 WO 1995003328A3 EP 9402369 W EP9402369 W EP 9402369W WO 9503328 A3 WO9503328 A3 WO 9503328A3
Authority
WO
WIPO (PCT)
Prior art keywords
iib
iia
protein
melanoma
htz
Prior art date
Application number
PCT/EP1994/002369
Other languages
English (en)
French (fr)
Other versions
WO1995003328A2 (de
Inventor
Ulrich Bogdahn
Reinhard Buettner
Brigitte Kaluza
Original Assignee
Boehringer Mannheim Gmbh
Ulrich Bogdahn
Reinhard Buettner
Brigitte Kaluza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh, Ulrich Bogdahn, Reinhard Buettner, Brigitte Kaluza filed Critical Boehringer Mannheim Gmbh
Priority to DE59408791T priority Critical patent/DE59408791D1/de
Priority to JP50493195A priority patent/JP3435163B2/ja
Priority to CA002167693A priority patent/CA2167693C/en
Priority to DK94925364T priority patent/DK0710248T3/da
Priority to EP94925364A priority patent/EP0710248B1/de
Priority to AU75312/94A priority patent/AU7531294A/en
Priority to US08/578,649 priority patent/US5770366A/en
Publication of WO1995003328A2 publication Critical patent/WO1995003328A2/de
Publication of WO1995003328A3 publication Critical patent/WO1995003328A3/de
Priority to GR990403299T priority patent/GR3032212T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft ein Melanom-inhibierendes Protein, für dieses Protein codierende Nukleinsäuresequenzen, Verfahren zur Gewinnung dieses Proteins sowie dessen Verwendung zur Herstellung eines Therapeutikums.
PCT/EP1994/002369 1993-07-20 1994-07-19 Melanom-inhibierendes protein WO1995003328A2 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE59408791T DE59408791D1 (de) 1993-07-20 1994-07-19 Melanom-inhibierendes protein
JP50493195A JP3435163B2 (ja) 1993-07-20 1994-07-19 黒色腫阻害蛋白質
CA002167693A CA2167693C (en) 1993-07-20 1994-07-19 Melanoma-inhibiting protein
DK94925364T DK0710248T3 (da) 1993-07-20 1994-07-19 Melanom-inhiberende protein
EP94925364A EP0710248B1 (de) 1993-07-20 1994-07-19 Melanom-inhibierendes protein
AU75312/94A AU7531294A (en) 1993-07-20 1994-07-19 Melanoma-inhibiting protein
US08/578,649 US5770366A (en) 1993-07-20 1994-07-19 Melanoma-inhibiting protein
GR990403299T GR3032212T3 (en) 1993-07-20 1999-12-22 Melanoma-inhibiting protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4324247.2 1993-07-20
DE4324247 1993-07-20

Publications (2)

Publication Number Publication Date
WO1995003328A2 WO1995003328A2 (de) 1995-02-02
WO1995003328A3 true WO1995003328A3 (de) 1995-03-16

Family

ID=6493222

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/002369 WO1995003328A2 (de) 1993-07-20 1994-07-19 Melanom-inhibierendes protein

Country Status (14)

Country Link
US (1) US5770366A (de)
EP (2) EP0710248B1 (de)
JP (1) JP3435163B2 (de)
CN (1) CN1056617C (de)
AT (1) ATE185152T1 (de)
AU (1) AU7531294A (de)
CA (1) CA2167693C (de)
DE (2) DE4425481A1 (de)
DK (1) DK0710248T3 (de)
ES (1) ES2139751T3 (de)
GR (1) GR3032212T3 (de)
IL (2) IL154248A (de)
WO (1) WO1995003328A2 (de)
ZA (1) ZA945278B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19653358A1 (de) * 1996-12-20 1998-06-25 Boehringer Mannheim Gmbh Immunoassay zum Nachweis von MIA
JP2001509029A (ja) 1997-01-21 2001-07-10 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド ヒトタンパク質
US6492144B1 (en) * 1997-05-30 2002-12-10 Diagen Corporation Methods for detection of nucleic acid sequences in urine
USRE39920E1 (en) 1997-05-30 2007-11-13 Xenomics, Inc. Methods for detection of nucleic acid sequences in urine
EP0945507A1 (de) * 1998-03-27 1999-09-29 Boehringer Mannheim Gmbh Tumorspezifische Expressionskontrollregion und deren Verwendung
US20020103360A1 (en) * 1998-09-01 2002-08-01 Yang Pan Novel protein related to melanoma-inhibiting protein and uses thereof
US20030072767A1 (en) * 1998-09-30 2003-04-17 Alexander Gaiger Compositions and methods for WT1 specific immunotherapy
EP1025871A1 (de) * 1999-01-28 2000-08-09 F. Hoffmann-La Roche Ag Verwendung eines melanonhemmenden Faktors zur Reperatur von Knorpelgewebe und Knochen
US6713293B1 (en) * 1999-02-08 2004-03-30 Friedrich Grummt Encapsulated cells containing an amplified expression vector as a drug delivery device
US6797483B1 (en) 1999-06-30 2004-09-28 Takeda Chemical Industries, Ltd. Polypeptide and DNA thereof
WO2001055332A2 (en) * 2000-01-25 2001-08-02 Hyseq, Inc. Methods and materials relating to novel growth regulatory-like polypeptides and polynucleotides
EP1133994A1 (de) * 2000-03-11 2001-09-19 Biognostik Gesellschaft für biomolekulare Diagnostik mbH Verfahren zür Umwandlung des immunosuppresive effekts von MIA (Melanoma Inhibitory Activity)
IL150679A0 (en) * 2000-03-23 2003-02-12 Akzo Nobel Nv Use of mia in immunotherapy
US6613534B2 (en) 2001-03-20 2003-09-02 Wake Forest University Health Sciences MAP-2 as a determinant of metastatic potential
US20100212037A1 (en) * 2002-10-16 2010-08-19 Anja Katrin Bosserhoff Mia-2 protein
KR20090046893A (ko) * 2006-07-28 2009-05-11 노파르티스 아게 흑색종에서 치료학적 반응에 대한 조기 지표로서의 흑색종 억제 활성 (ｍｉａ) 단백질의 용도
ES2660785T3 (es) * 2007-08-22 2018-03-26 Trovagene, Inc. Métodos de uso de ARNmi para la detección de la muerte de células in vivo
SG10201908916UA (en) 2010-04-27 2019-11-28 Scil Tech Gmbh Stable MIA/CD-RAP formulations
CA2807431A1 (en) * 2010-08-30 2012-03-08 F. Hoffmann-La Roche Ag Prokaryotic expression construct
ITRM20110134A1 (it) * 2011-03-22 2012-09-23 Matteo Bordignon Inibitori di mia (attività inibitoria melanoma) per identificare, prevenire e curare la vitiligine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R.APFEL ET AL.: "Purification and analysis of growth regulating proteins secreted by a human melanoma cell line", MELANOMA RES., vol. 2, no. 5-6, 1992, pages 327 - 36 *
U.BOGDAHN ET AL.: "Autocrine Tumor Cell Growth-inhibiting Activities from Human Malignant Melanoma", CANCER RESEARCH, vol. 49, 1989, pages 5358 - 5363 *

Also Published As

Publication number Publication date
EP0947583A3 (de) 2000-05-03
JP3435163B2 (ja) 2003-08-11
DE59408791D1 (de) 1999-11-04
EP0710248B1 (de) 1999-09-29
IL154248A0 (en) 2003-09-17
WO1995003328A2 (de) 1995-02-02
GR3032212T3 (en) 2000-04-27
ZA945278B (en) 1996-01-19
EP0947583A2 (de) 1999-10-06
IL110385A (en) 2003-12-10
US5770366A (en) 1998-06-23
CA2167693C (en) 2007-01-30
AU7531294A (en) 1995-02-20
EP0710248A1 (de) 1996-05-08
CN1133049A (zh) 1996-10-09
ES2139751T3 (es) 2000-02-16
JPH09500531A (ja) 1997-01-21
CA2167693A1 (en) 1995-02-02
CN1056617C (zh) 2000-09-20
ATE185152T1 (de) 1999-10-15
DK0710248T3 (da) 2000-04-10
IL110385A0 (en) 1994-10-21
IL154248A (en) 2008-08-07
DE4425481A1 (de) 1995-03-02

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