WO1995001167A3 - Incorporating poly-n-vinyl amide in a transdermal system - Google Patents

Incorporating poly-n-vinyl amide in a transdermal system Download PDF

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Publication number
WO1995001167A3
WO1995001167A3 PCT/US1994/007267 US9407267W WO9501167A3 WO 1995001167 A3 WO1995001167 A3 WO 1995001167A3 US 9407267 W US9407267 W US 9407267W WO 9501167 A3 WO9501167 A3 WO 9501167A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
vinyl amide
poly
permeation
transdermal system
Prior art date
Application number
PCT/US1994/007267
Other languages
French (fr)
Other versions
WO1995001167A2 (en
Inventor
Felix A Landrau
Diane E Nedberge
Linda M Hearney
Original Assignee
Alza Corp
Felix A Landrau
Diane E Nedberge
Linda M Hearney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22172334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1995001167(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp, Felix A Landrau, Diane E Nedberge, Linda M Hearney filed Critical Alza Corp
Priority to DE69401945T priority Critical patent/DE69401945T3/en
Priority to EP94923905A priority patent/EP0705097B2/en
Priority to JP7503596A priority patent/JPH08512054A/en
Priority to US08/564,058 priority patent/US5919478A/en
Priority to AU73962/94A priority patent/AU7396294A/en
Publication of WO1995001167A2 publication Critical patent/WO1995001167A2/en
Publication of WO1995001167A3 publication Critical patent/WO1995001167A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention comprises a composition comprising a matrix (12) adapted to be placed in drug- and permeation-enhancing mixture-transmitting relation to a selected skin (18) or other body site. The matrix (12) contains sufficient amounts of drug, permeation enhancer(s) and poly-N-vinyl amide to continuously administer to the site, the drug, in a therapeutically effective amount, and the permeation-enhancing mixture, in an amount effective to enhance the permeation of the skin (18) to the drug, the device (10) shows increased transdermal flux as compared to the transdermal flux of the drug from a device (10) containing no poly-N-vinyl amide. Incorporating poly-N-vinyl amide into the transdermal system also improves the adhesion and stability of the system.
PCT/US1994/007267 1993-06-25 1994-06-24 Incorporating poly-n-vinyl amide in a transdermal system WO1995001167A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69401945T DE69401945T3 (en) 1993-06-25 1994-06-24 INTRODUCTION OF A POLY-N-VINYLAMID INTO A TRANSDERMAL SYSTEM
EP94923905A EP0705097B2 (en) 1993-06-25 1994-06-24 Incorporating poly-n-vinyl amide in a transdermal system
JP7503596A JPH08512054A (en) 1993-06-25 1994-06-24 Inclusion of poly-N-vinylamide in transdermal system
US08/564,058 US5919478A (en) 1993-06-25 1994-06-24 Incorporating poly-N-vinyl amide in a transdermal system
AU73962/94A AU7396294A (en) 1993-06-25 1994-06-24 Incorporating poly-n-vinyl amide in a transdermal system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8262493A 1993-06-25 1993-06-25
US082,624 1993-06-25

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US8262493A Continuation-In-Part 1993-06-25 1993-06-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/300,010 Continuation US6248348B1 (en) 1993-06-25 1999-04-26 Incorporating poly-N-vinly amide in a transdermal system

Publications (2)

Publication Number Publication Date
WO1995001167A2 WO1995001167A2 (en) 1995-01-12
WO1995001167A3 true WO1995001167A3 (en) 1995-02-16

Family

ID=22172334

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/007267 WO1995001167A2 (en) 1993-06-25 1994-06-24 Incorporating poly-n-vinyl amide in a transdermal system

Country Status (8)

Country Link
US (2) US5919478A (en)
EP (1) EP0705097B2 (en)
JP (1) JPH08512054A (en)
AT (1) ATE149349T1 (en)
AU (1) AU7396294A (en)
DE (1) DE69401945T3 (en)
WO (1) WO1995001167A2 (en)
ZA (1) ZA944608B (en)

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US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents

Also Published As

Publication number Publication date
DE69401945D1 (en) 1997-04-10
EP0705097B1 (en) 1997-03-05
US6248348B1 (en) 2001-06-19
JPH08512054A (en) 1996-12-17
US5919478A (en) 1999-07-06
EP0705097A1 (en) 1996-04-10
DE69401945T2 (en) 1997-06-12
DE69401945T3 (en) 2004-09-02
AU7396294A (en) 1995-01-24
EP0705097B2 (en) 2004-01-14
ATE149349T1 (en) 1997-03-15
ZA944608B (en) 1995-03-24
WO1995001167A2 (en) 1995-01-12

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