WO1994016103A3 - Detection of synthetic oligonucleotides extracted from body fluids or tissues - Google Patents

Detection of synthetic oligonucleotides extracted from body fluids or tissues Download PDF

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Publication number
WO1994016103A3
WO1994016103A3 PCT/US1994/000297 US9400297W WO9416103A3 WO 1994016103 A3 WO1994016103 A3 WO 1994016103A3 US 9400297 W US9400297 W US 9400297W WO 9416103 A3 WO9416103 A3 WO 9416103A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissues
detection
synthetic oligonucleotides
body fluids
extracted
Prior art date
Application number
PCT/US1994/000297
Other languages
French (fr)
Other versions
WO1994016103A2 (en
Inventor
Jamal Temsamani
Sudhir Agrawal
Original Assignee
Hybridon Inc
Jamal Temsamani
Sudhir Agrawal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc, Jamal Temsamani, Sudhir Agrawal filed Critical Hybridon Inc
Priority to KR1019950702852A priority Critical patent/KR960700349A/en
Priority to JP6516256A priority patent/JPH08507437A/en
Priority to EP94909444A priority patent/EP0680518B1/en
Priority to DE69402683T priority patent/DE69402683T2/en
Priority to AU62288/94A priority patent/AU678821B2/en
Publication of WO1994016103A2 publication Critical patent/WO1994016103A2/en
Publication of WO1994016103A3 publication Critical patent/WO1994016103A3/en
Priority to FI953364A priority patent/FI953364A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

The invention provides a method for detecting specific synthetic oligonucleotides that are present in body fluid or tissue samples taken from an animal or human patient to whom oligonucleotides have been administered.
PCT/US1994/000297 1993-01-08 1994-01-07 Detection of synthetic oligonucleotides extracted from body fluids or tissues WO1994016103A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1019950702852A KR960700349A (en) 1993-01-08 1994-01-07 DETECTION OF SYNTHETIC OLIGONUCLEOTIDES EXTRACTED FROM BODY FLUIDS OR TISSUES
JP6516256A JPH08507437A (en) 1993-01-08 1994-01-07 Detection of synthetic oligonucleotides extracted from body fluids or tissues
EP94909444A EP0680518B1 (en) 1993-01-08 1994-01-07 Detection of synthetic oligonucleotides extracted from body fluids or tissues
DE69402683T DE69402683T2 (en) 1993-01-08 1994-01-07 DETECTION OF SYNTHETIC OLIGONUCLEOTIDS EXTRACTED FROM BODY LIQUIDS OR TISSUE:
AU62288/94A AU678821B2 (en) 1993-01-08 1994-01-07 Detection of synthetic oligonucleotides extracted from body fluids or tissues
FI953364A FI953364A (en) 1993-01-08 1995-07-07 Detection of synthetic oligonucleotides extracted from body fluids or tissues

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US278693A 1993-01-08 1993-01-08
US5636393A 1993-04-30 1993-04-30
US08/056,363 1993-04-30
US08/002,786 1993-04-30

Publications (2)

Publication Number Publication Date
WO1994016103A2 WO1994016103A2 (en) 1994-07-21
WO1994016103A3 true WO1994016103A3 (en) 1994-09-01

Family

ID=26670869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/000297 WO1994016103A2 (en) 1993-01-08 1994-01-07 Detection of synthetic oligonucleotides extracted from body fluids or tissues

Country Status (12)

Country Link
US (1) US5693466A (en)
EP (1) EP0680518B1 (en)
JP (1) JPH08507437A (en)
KR (1) KR960700349A (en)
CN (1) CN1116859A (en)
AT (1) ATE151816T1 (en)
AU (1) AU678821B2 (en)
CA (1) CA2153504A1 (en)
DE (1) DE69402683T2 (en)
FI (1) FI953364A (en)
NZ (1) NZ262561A (en)
WO (1) WO1994016103A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008036A1 (en) * 1987-04-08 1988-10-20 Invitron Corporation Detection and identification of dna and/or rna in protein-containing samples
EP0324474A1 (en) * 1988-01-12 1989-07-19 Roche Diagnostics GmbH Method for the detection of nucleic acids
WO1992000983A1 (en) * 1990-07-13 1992-01-23 Microprobe Corporation Non-corrosive composition and methods useful for the extraction of nucleic acids
WO1992018649A1 (en) * 1991-04-12 1992-10-29 Microprobe Corporation Compositions and methods for improved extraction and hybridization of nucleic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483920A (en) * 1982-05-17 1984-11-20 Hahnemann University Immobilization of message RNA directly from cells onto filter material
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US5149798A (en) * 1989-04-06 1992-09-22 Worcester Foundation For Experimental Biology Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses
US5223402A (en) * 1990-08-30 1993-06-29 Difco Laboratories Method of detecting microbes utilizing chemiluminescent compound

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008036A1 (en) * 1987-04-08 1988-10-20 Invitron Corporation Detection and identification of dna and/or rna in protein-containing samples
EP0324474A1 (en) * 1988-01-12 1989-07-19 Roche Diagnostics GmbH Method for the detection of nucleic acids
WO1992000983A1 (en) * 1990-07-13 1992-01-23 Microprobe Corporation Non-corrosive composition and methods useful for the extraction of nucleic acids
WO1992018649A1 (en) * 1991-04-12 1992-10-29 Microprobe Corporation Compositions and methods for improved extraction and hybridization of nucleic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AGRAWAL, S. ET AL: "Pharmacokinetics, biodistribution, and stability of oligodioxynucleotide phosphothroiates in mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, September 1991 (1991-09-01), WASHINGTON US, pages 7595 - 7599 *

Also Published As

Publication number Publication date
FI953364A0 (en) 1995-07-07
DE69402683T2 (en) 1997-09-25
DE69402683D1 (en) 1997-05-22
WO1994016103A2 (en) 1994-07-21
EP0680518A1 (en) 1995-11-08
FI953364A (en) 1995-07-07
CA2153504A1 (en) 1994-07-21
AU678821B2 (en) 1997-06-12
KR960700349A (en) 1996-01-19
CN1116859A (en) 1996-02-14
AU6228894A (en) 1994-08-15
ATE151816T1 (en) 1997-05-15
JPH08507437A (en) 1996-08-13
NZ262561A (en) 1997-01-29
US5693466A (en) 1997-12-02
EP0680518B1 (en) 1997-04-16

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