WO1994000116A1

WO1994000116A1 - Agent with adaptogenic activity

Info

Publication number: WO1994000116A1
Application number: PCT/RU1993/000138
Authority: WO
Inventors: Nonna Dmitrievna Kislyakova
Original assignee: Nonna Dmitrievna Kislyakova
Priority date: 1992-06-26
Filing date: 1993-06-28
Publication date: 1994-01-06
Also published as: JPH07500846A; CA2116575A1; AU4591993A; RU2038077C1; HUT71836A; HU9400574D0

Abstract

The invention relates to medicine, in particular, to experimental and clinical therapy and may be used for adaptogenic influence on a human organism subjected to extreme conditions or having gone through a serious illness. It is proposed to use synthetic amino acid DL-valine as an agent with adaptogenic activity. DL-valine, causing the state of nonspecifically heightened resistance of mammal's organism, in particular human organism, increases its mental and physical working capacity as well as normalizes its psychical activity. Its influence is also characterized by a significant increase of the immune protection of the organism, disappearance of some chronic inflammations, normalization of the metabolism and of the functional state of the liver, and of the cardiovascular system. The proposed agent easily synthetically obtained and functioning as a nutrition component of human food ration does not have any adverse side effect and may be widely used for prophylaxis as well as physical and psychical sanitation of the population.

Description

Immediately possessing an adaptive active.

Ηzοbρeτeniθ οτnοsiτsya κ οblasτi meditsinιι in chasτnοsτi, v eι.οηορimeπτelnοy and κlshιichesκοy τeρeηii and mοzheτ bnτ πspοlzοvanο for οdaητοgeιshοgο vοzdeysτviya on ορgaiizm chelοveκe on ^χ οdyaschegοsya in zι with - ~ - l.ν.sh. Conditions or severe illness, this is an emergency for your mental health problems.

Izvesτny sρedsτva ρasτiτelnοgο προisχοzhdeniya, οbladayuschie πdeπτοgeshshιli deysτviem, naπρimeρ, eκsτρaτy κορney zheiyιιenya and elοuτeροκοκκa, sποsοbnye vyzyvaτ SΟSΤΟYAΗIΘ nesηecheφichesκi ηοvn- shοshyun sοπροτivlyaemοsτi ορganizma mleκοηiτayuschiχ.

In the event of an adverse condition, adverse effects on the living environment were obtained from the adverse effects of the adaptations on the part of the laboratory. . . .

The source of the extract of the outer eleuthera ηο 2 ml per day) in the course of: -.-: • -: kuruev (on the first month of every month) in winter time: ^"LCHΘΟGLΧ πρedπρπyaτy in τyazhelyχ ιslimaτichesκiχ uslοviyaχ ηοκezel zπmeτnοο sshshenie in mnοgiχ persons προsτudnyχ zabοlevany.

Zτοτ ηρeπaρaτ ρeκοmendοvan for ηοvysheniya ρabοτοsποsοbnοsτi in uslοvυya ^χ Seveρa. Eκsτρaκτ of κορnya zhenyienya sποsοben sτimuliροvaτ τ ^η and ϊϊgιο sΤuiκtsshο κορy gοlοvnοgο mοzga. . (sm.Bρeχman GI with sοavτ "Ιϊteuτeροκοκκ - sρedsτvο ηοvysheniya nesηetsiφichesκοy sοηροτivτyaemοsτi ορganizπa" Publishers vο ΛΗ SSSΡ, seρiya May 1965, s.762-764 and τayuιe in ι ⁱⁿ K "Ηοvye data οb eleuτeροκοκκe. and other eductogenes "" д ив ив ив,,,,, ΙΙ ΛΙΙ СССΡ, Ι98Ι, с.7Э-83, 88-112). Οdneκο, admιτοgenπyο οροποτ g.esτpτelyyugο ηροis ^χ οzhdeniya imeyuτ suschesτvennye nedοsτaτκi: 2. I) There was a limited seasons of activity, that is, the most common disease-related properties are detected in them only in the all-winter winter; 3) the availability of large sources of raw materials for the source of radiation is often associated with a high risk of failure, as a result of which there is a risk of damage to the device

Sρedi legκο ηοluchaemyχ and ηοeτοmu bοlee dοsτuπnyχ sinτeτπchesκi ^χ edeπτοgeπnyχ sρedsτv, κροme dibazοla and less meρe neκοτορy ^χ οgο προnzvοdniχ, ηρaκτichesκi ηοκa not identified with veschesτva vyρezhennshl πdaπτοgeπnym deisτvnem. Τ.ο. A well-known synthetic device has a predominantly electronic component - dibazole, taken from the burner as a part of the process. Ι see Husnn B.L. "06 adaptation of cold and heat и and muscular muscle введ введ введ введ введ introduction of dibazole", g. "Patient Physiology and Experimental Theory", 1962, 6, p. 63-65 and ohm. Ροзин Μ.Α. , "The state of escrow is elevated. We are cooperating with the operation of a short-term business environment" chapter in the book. 'Ηesηetsiφichesκaya leκaρsτvennaya nρο.ϊchιlaκτiκe and τøρagshya ρaκa "ΑΙΛΗ SSSΡ, L., ed-vο" Μeditsina ":. 1968 e..37-29) β eg.sieρimenτelnyχ uslοviyaχ for dοκazaτelsτve adaητοgennyχ svο'ϊsτv dzbazοla egο vvοdili ΠΟDΚΟZHΗΟΉE in φizρesτvορe 1. κοlichesτve πg πη I κg weight zhivοτnοgο ezhednevnο τechenie in 30 days. Eτο vmzyvalο 7.givοτπnχ edaητatsπyu χοlοdu κ, κ τeπlu, ποvyshenpe ροbοτοsποsοbnοsτi ιG _'Pϊι ππ nοe πlavanie e).

Dybazol may be restricted for use in non-operative and non-operative gastrointestinal tracts and angiopathy. ϋuschesτvenπym nedοsτaτκοm dibazοla, κaκ iνdοπτοgenοv ρasτπτel- nοgο nροπs ^χ οschιenπya YAΒLYAΘΤSYA vyρezheπneya sοzοineya οgρenichennοsτ egο ποποτvπya τοlκο in οsenne-winter vρeglya.

8

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OTHER ESSENTIAL DIBASOLE IS AN EXTRAORDINARY ACTION: the vessel is extensible. ΓIΠΟΤΘΗZIΒIΟΘ, blagοdaρya chβmu οn in οsnοvnοm isποlzuθτsya for κuπiροvaniya gshιβρτθnzivnyχ κρizοv in bοlnyχ πρi οbοsτρenii giπeρτοnichesκοy bοlezni. / Sm.Μashκοvsκy M "Leκaρsτvennyθ sρødsτva" h »Ι Μ, SVS-vο" Μθditsina ", 1985. , сτρ. 45ϋ- 451./

Taking into account the foregoing, it is proposed to use synthetic D1 _* amanoxides in the quality of the medium, which has an a-reactive activity.

The well-known use of D-valine as a part of the former amphibious acid, which is a part of amino acids, is: aminusin, oterein, τρ _; Izanami, πρimenyaemyχ for power The πaρenτeρalnοgο, κοτοροe οbesπechivaeτ azοτnyθ ποτρebnοοτi ορganizma χiρuρgichesκiχ bοlnyχ ποsle chasτichnοgο or ποlnοgο remove zhθlutsκa. / sm.Sudzhan Λ in κn. "Paρenτeρalnοθ πiτaniθ in bnκοχiρuρgii" M, ed-vο "Μeditsina"

There is also a known application of the D-valine in the terms of the export business as a result of the blessing of the good news. certificate of the invention '751) 787 out of 28. W.1980 Α 61 Κ 31/195, ϋ ø ø ø с, б б лада б а а а,,,,,,,,,,, ав ав ав ав ав ав ав ав ав ав. , with me /.

Β οτlichie οτ izvesτnyχ adaπτοgenοv ρasτiτelnοgο προisχοzhdeniya and οτ izvesτnοgο sinτeτichesκοgο adaπτοgena-dibazοla dL valine iροyavlyaeτ svοi adaπτοgennyβ svοyοτva not τοlκο in zimnβ-οsβnny, nο π in veοennθ-leτny πøρiοd causing sοsτοyanie nesπetsiο-ichesκi pοvyshennοy sαπροτivlyaemοsτi ορganizma mlθκοπiτayuschiχ in chasτnοsτi, chϋlοveκa bοlee glubοκο expressed. and with a long investigation. 4. Industrial access to the people of the Republic of Belarus on the other hand, in person. οτ izvesτπy ^χ πdaπτοgenοv vyρazhaeτsya as follows:

1. B suschesτvennοm ηοdnyaτii immunοusτοychivοsτi ορgenizma chelοveκa κο all "προsτudnym" zabοlevanishl (0Ρϋ, Ani-Ηa, φaρingiτ, pοsτgρiποznye οslοzheniya and dρ.) ΗΘ τοlκο in οsenne-zimnϊ _'ϊy πeρiοd, nο and spring leτnii, chτο not svοysτvennο no analogue, nor any other means.

2. With the weakening, and η и τв π в ρ ρ вали,,,,,,,,,,,,,,, вали,, вали вали вали вали вали вали вали вали вали вали вали Б, ρ и ρ ρ Б Б Б Б Б Б Б Б Б Б Б Б Б Б Б Б Б Б Б. Stable stability is found in the environment (biological substances (bacterial substances).

Interestingly, after only a few days from the beginning of the beginning of the beginning of the year, it is often not uncommon for the sensation of pain in the place to be forgotten, it was already forgotten. After 2–3 days, this feeling is completely disappearing and no longer appears. The benefits of the elsewhere are more pronounced among other adherents less pronounced and less studied.

3. The quick normalization of the exchange of exchanges as the general exchange (normalization of the weight of the person), as well as the separate physical events, the normal operation of the With the return of the corpses of this, the normalization deepens and accumulates.

4. Regulating and nourishing influence on the higher and the highest human activity, i.e. to its present state. Τeκ, y lπts with bοlee or less vyρazheshshmi πρiznaκami asτenοdeπρessivnοgο siidροma with ^η οsτοyannym chuvsτvοm ηοdevlennοsτi, τρevοgi and naοbοροτ, y lυts, ποdveρzhenny ^χ ηρisτuηam ρezκοgο vοzbuzhdeniya πρi neadοκg.ητnοη ^ϊeοκts' ϊi the weak ρazdρazhiτel (slabοsi τορmοznyχ προtsessοv) already . : ^{5 ”} at the beginning of the first month of the death of D ϊ», the condition is disturbed: the manifestation of the sensibility of accidents is disturbed, the accident is detected If you take away the food, we offer you a safe place after 6-7 months, but this is not normalized.

Pοdοbnοe ρeguliρuyuschee vοzdeysτvie on πsiχiκu chelοveκa cheρez sτsh.τulyatsπyu φunκtsii κορn gοlοvnοgο mοzga of vseχ nzvesτiyχ adaητοgenο οpοsοbοn οκezyvaτ τοlκο ginseng κοτορym οdnaκο least dοsτuηen for shπροκοgο isηοlzοvaniya sρedi population due οgροl-sh- cheπnοsta ροsτiτelygagο syρya.

Κροme τοgο πρimenenie ginseng ηρi ρazlichnοy vyρel'.ennοsτn οsτenοdeπρessivnοgο sindροma vedeτ τοlκο in vρemennοmu improve nsιsh.chesκοgο sοsτοyaniya chelοveκa, nο not κ zaκρeπlennοy nορmelπzatsiπ egο, κaκ if πρiema πρedlagaemοgο sρedsτva. (see Petkov B.

"The mechanism of action of ginseng in the quality of regulation of the activity of the organism" in the book. 'New data on eleuthero and other eductogenes' ив ив ив ив ив;; ΒΗ; ΑΙΙ Ρ СССΡД98ΑΙΙ, о.Юб-112).

5. With the active participation of D-Valine in the process of quick and long-term maintenance, there is an increased incidence of increased stress in the home. 'Οτο, perhaps, is associated with the active influence of DΖg-valiye. in the general η process, in particular, the exchange of cleanliness, proteins, in a continuous τκ ^{η has a} central non-continuous system.

6. With a significant reduction in fatigue and a greater increase in physical efficiency, in the event of a decrease in the speed of operation

Uchiτyvaya, chτο ποdοbnοe vοzdeysτvie D -velina πe ορgenizg chοlοveia- € πορτsmeie, ηοlnοsτyu lishenο sezοnnyχ οgρenicheniπ πο sηοvieιshyu with dρugimi edaπτοgenami, οnο πρiοbρeτaeτ οsοbuyu tsennοsτ. 6.

Τ.ο. The proposed medium is newly acquired, t.κ. In general, the quality of the adaptation is unknown at the current level of development of depression.

The inventive level of the present invention is explicitly derived from the prior art of the development of modern medicine of the enegy).

The invention may have been extensively implemented in the manufacture of a private, public, and public health facility. The essentials are expressed in terms of the availability of essential products for the achievement of the desired result.

To prove the availability of all goods, you have:;; а ш ш а да да да у у ед ед ед ед ед ед ед лаг ед ед ед лаг;;;;;;;;;;;;;;;;. τeκzhe for ρasκρyτiya neκοτορyχ meχznizmοv φορmiροvaniya eτi ^χ svοisτv, byln iροvedeny eκsηeρimenτalnye issledοvashιya ne belyχ besηοροdnyχ κρysaχ, ηοdveρgavshiχsya vοzdοysτvgaο D -valine in sρavnenii with κοnτροlηymπ gρuππami τaκiχ same zhivοτnnχ (without vοzdeysτviya) and gρuιshag ηοtsvορgπvshimπsya vοzdοysτviga IZΒΘSΤΗΟΓΟ sρedsτve - dπbazοla (ηροτοτiπ).

First of all, I was divided by a little before entering the stomach (the sound in my stomach) in the small ϊ> -valna for the family of the males.

Bnlο usτanοvlenο, chτο dliτelyyusτ vvedeιshya in dnyaχ s dοled in .'ϊchτyuτιsh ^χ ηρevyshaτ 3-4 weeks (ϊ ρaz in suτκi, 5 day in nedelga). 13 In the event of accident, there is a failure to reduce the incidence of ηπ ^η due to the [»-value being accessed. Οuτοchnaya dοza D ^ -valπna ηπvisπτ ΤΟCHΤ-ΛΌ ΟΤ ΜESSΗ τelο zhivοτnοgο, d.lya zhivοτnyχ with messοy τele Τ00-Ι50 g dοz ^η D -vπlπιyu sοsτοvlyaeτ ne 40 mg 100 g ιlessy zhivοτnοgο in for gπvοτιyugο with messοy οκοlο 200g π above - a dose of 60 πg per 100 g of inssa. "зο Бτ..... Б Б. Avoiding the appearance of the aminosocial dysbayans. - Well, it’s on the other hand. 7. Peρvenechelnο edaπτοgennye svοysτva d L-valine were προveρeny πρn οdπορazοvοm egο administered ea I hour dο vοzdοysτviya ηeblegοηρiyaτn (ηπg.τορa, πο all οbscheηρinyaτyιl τesτam cm. Κοvalev G.Β. with sοavτ. "Κ sρevniτelnοy adaητοgennοy and anτisτρessορnοy aκτivnοsτi with sοedinen ρazlichnοn ΧIΜICHΘSΚΟY sτρuκτuροy ". ιsh in" Ηοvye data οb eleuτeροκ ΚCHΘ n dρ adaητοgenaχ "Βladivοsτοκ;. DΒΗTS ΑΗ SSSΡ Ι98Ι, s.51-56) in the spring-leτny πeρiοd ^(aπρel, May iyun) chτοby iοdτveρdiτ οτsuτsτvie sezοnιyuy zavisimοsτi in the statement of its active.

At this time, in parallel with this, under the conditions of ^χ э de ^η taegene, the dibazole has been operating for a whole time without any faults in the system.

There is a wide range.

I ΤΕСΤ. Evaluation of the influence of D-zelen on the general physical ability to work ⁽ first-hand sailing). The Beloved Beluga ^χ inferior κ krys-males (weight 250–260 g): 10 experienced and 10 ж ж ж ж ж ж ж ж ж ж....... Both the temperature and the temperature (after the second day) of the left water temperature were + 21 ° С. The shyavali shores of и э ρ,,,, ы ы ы и и и и и и и син син син син син син син син син син син син син син син син син син син син син син син син син син син син син син син син син,,, син,,,,, ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы ы Experienced live performances before 60 minutes before loading in the water were received by the probe in the ACORN; L 1> -valin ⁽ 60 mg) per 100 g weight in I ml of milk), and the most similar to the corresponding weight of a small baby in 100 g.

Increasing vρemeni ποvτορnοgο ηlavaniya at οπyτnyχ .shvοτiyχ οοοτοvilο in minuτaχ 8.25 + 1.47, y e κοnτροlnyχ, sοοτveτsτvennο, 3,40+ 1.36 τaκ chτο ρ 0,05 (sτaτ.οbρabοτκa οbscheπρinyaτshl iaρemeτρi- chesκπm meτοdοm with πsηοlzοvaniem The circumstance "" Strange - *} ishera), which says that there is higher physical work. The introduction of the D / -value.

Β ^χ Te same uslοviyaχ was ηροvedena προveρκe edeητοgennοgο deϊϊsτviya dibazοla ϊθ οπyτnyχ and 10 κοnτροliyχ besiοροdnyχ κρys-

cm, weight 200-215 g). Dibazole, located in the ρ-ρ з з, з ге, 8. Injection of vigorous and lively food in quantities of 0.1 mg per 100 g of weight in 0.2 л of ге ге ρ ρ ((I д д г / веса веса - - - -))))))))))))))))))))))))) To the normal diet τοτυ.е p / κ introduced ρ-ρ Ρingera ⁽ 0.2 ml per 100 g of weight).

Increasing vρemeni ηοvtορnοgο πlavaniya in οπyτnο.ϊ gρuπde bylο dοsτοvορnο nπzhe 4.12 + 0.37) than in κοnτροlnοy 4.37 + 1.25) πρi ρ / .ϋ, 05, chτο gοvορiτ οb οτsuτsτvii ποvysheniya ρabοτοsηοsοbnοsτi πρi vοzdοποτvnn dibazοlο and even its decline, possibly due to the seasons of the deed.

And ΤΕСΤ. Pροveρκa zaιtsiτnοgο iροτdvοsudοροζτyugο deysτviya D -to ^η pρπ ποvρezκdeyuschem vοzdeysτvii sτρiχnina (φaκτορa χnmichesκοy gρπροdy). Possessed white inferior κ krys-males (weight 200-250 g). A group of 7 animals) for 60 minutes before the internal introduction of a toxic dose of 0.2 mg per 100 g, i.e. 0.2 ml of 0.1 ρ-ρa per 100 g of live weight - before the dose was taken, they were introduced into the tested dose (ga; full), and the live group (7).

Еч Not at all a good hour in the community there were a total of 2 livelihoods, and in the community - 7. Results: out of 7 live in the village, it was only 5. . Genes "Τablitsy dοsτοveρπyχ ρazlichy Meddi gρuπηηιlπ n ^η blgadοιshy ηο κachesτvennym ηοκazaτelyam" because vο "ΙLeditsina" Ι9S, sτρ. 11-15) in ρazlichiya vyzhivaemοsτi πρi vvedenπi D -valine ηο sρavnenηyu with g.οiτροlem dοsτοveρny cF _~. 0.025) .

Repetition of this test under the same conditions, but with the π / κ introduction π 00 of dibazole (the same dose is 0.2 ml of ρ-ρe, which contains 0.1 mg of pe ^[ 00 g of weight) does not result in On the 5th, the flow was 5, and in total 2. 2. On the last of 6 live ntal 6 and on the whole - * •. at the beginning '* shchere ρ ^> 0,025 - different due to disadvantage). 9. Βvedeniθ D- veliπa 'οκazalο vyρazhennοe zaschiτnοe deyοτvie in ΟΤLΠCHIΘ οτ dibazοla, προτiv ηοvρezhdayuschøgο φaκτορa ^χ imichesκοy ιιρiροdi.

Ш ΤΕСΤ. Pροveρκa usτοychivοοτi κ ηοvρezhdayuschemu φaκτορu bποlοgichesκοy ηρπροdy - vnuτρibρyushnοmu vvedenπyu astsiτnyχ ρeκοvy κlιeτοκ ^χ (shτamm ΟYA + ρaκ yaichniκοv κρys).

They used white, infinite κ (мс мс сам сам ο ΒΘ (ΒΘС 260-300 g), which went to the experienced. group ⁽ 8 animals) introduced the above dose of D-valine, and in the final ⁽ 7 animals) - small. After 50 minutes, the bulk of the load was discharged in good form and the liver washes were cleaned at a rate of 11.5 χ 10 cells per 100 g of weight. Survive in days in an experienced group of 15 41-20 days), and in end of 12.1 (7-15 days), = Ο.Ο`` ⁽ accessibility is greater if there is an increase of 0.05 .0,05; ιϊθπeρemθτρicheοκy meτοd sτaτ.οbρabοτκi iο κρiτeρiyu "AND" Βilκοκsοna- Ινϊοιshπ- UIτnY (see Ε.Κ. Ιubleρ ^'ο sοavτ in κn "Pρimeneniβ κρπτeρiev iθπeρameτρichesκοy sτaτdsτ ι iκa for οtsenκi ρazlichy bi ^χ gρuπη neblyudeny in... Medical and Biological Research "Μ., Ι9C9, p. 9).

Introduction of a D * -value increases the sustainability of live exposure.

Use of π / κ introduction of dibazole under the current conditions

I ensured the survival of live experimental groups (7 live) 13.4 ⁽ 8-17) days, and end 12.0 ⁽ 7-17) days, ρ 0.05, i.e. with a fair difference. Dibazol did not increase the stability of the lively live entertainment system.

11. ΤΕСΤ. Anti-virus effect.

According to the conditions of the method of cultivation, they were used for the female lynnis cystis (80-100 g weight). Ze 60 minutes the dο ηοdveshi venπya κρysam sτρess-οπyτnοy gρuπηy (7 ^{zhπvοτnyχ)} vvοdπli zοndοm in zhοludοκ πsπyτuemuyu dοzu d £ -valine, ο-sτρess κοnτροlchοi. thunder 10. .7 wonderful) - nice. The group of intact crumbs (II lively ^χ ) е ^η луч луч луч луч луч луч луч луч ι ед ед ед ед ед заб заб заб. These live, kak and 2 first groups (σ-experience and second-party accounts) were preliminarily denied the United Kingdom. Pρi οtsenκe in ballaχ vesοvyχ changes iadπο- chοchsh.κοv, τiglusa, selezenκi κοlichesτva and expressions of slizisτοy in κοπτροlvοy gρuππe (in sρavnenii with inτaκτnymi zhivοτnymi) bnlο ποluchοnο ballοv 9, and in οπyτnοy - 4. Ρaznitsa sοsτavila 5 ballοv, chτο gοvορiτ ο vysοκοη eiτπsτρessορnοy the activity of D-valine.

The result of this activity is at dibazole in analogue; The condition of ^χ 7 intro and 7 kontrolny live animals) gave 7 points in the online group, and 6 points in the experimental one. The Russian Federation sent I a note that there was no guarantee that there was an interference with this assessment in accordance with the assessment.

The data obtained testified to the pronounced educto-active action for the _> -value for its independent operation in the course of the year.

There was a comparison of long-term exposure to wave (4 weeks) and there was no need for increased use of Indented results were obtained.

Additional long-term travel (4 weeks) ϊ »-valina in the spring season was another two trips in addition to a large livelihood.

ΤΕСΤ. Sustainability for the benefit of the user

π з че че че - - - - - good weather lοlοdοvοe ΒΟZDΘYSΤΒIΘ on beοποροdiyχ κρys in vesenshsh πeρiοd Ιgyus 100-130 g) οsuschesτvlyayai -ge iοsle ezhednevnοy (24 days without πeρeρyv ^η) vvοdenπya DΛ -valine 40 mg per 100 g of body weight lshvοτnοgο (πa οπyτπeya gρu ^η) and mοlοκa (κοnτροly-ιaya gρuππa ) by placing them for 5 minutes in mορο- zτιlnuιο ιsameρu ηρi τemπeρaτuρe - ΙΟ ^ C ^ ezulτaτ οtsenivali ηο changed ρeκτelyyuy τemπeρaτuρy in κadtsοgο οπyτποgο and κοnτροlnοgο zhivοτnοgο. We took a note of / / and made it immediately after having been operated

Κ end group (20 live) up to 1 * exposure - in the mean time it made up Μ ^ _^ Sδ.E ^ S, and after the entry Μ „ _g . = 38,! 5 ° С (ϊϊ) = 0ДΙ5; ρ -40.05), τ.θ. There is a noticeable decline in the market.

With a lively group (20 live) there was a corresponding “result”: exposure Μ _c = 39 ° C, and after Μ = 33.9 ° C (+ / * = 0.154; ρ> 0, therefore, decrease that proves the increase in the sustainability of the body of the organism.meaning to a significant degree of indefinitely long-term ηpiyemu D ^ -valina.

UΙ ΤΕСΤ. Converting a beam of (protective) protection D]. - Valina, in the spring season.

Β 2 οπyτzχ were isποlzοvaiτ: in πeρvοm - besποροdnye ιφnοy-samκi (100-120 g), 10 κοnτροliyχ, ηοlιuchaβο / Their mοlοκο 4 nedelπ claim 9 οiyτπy zhivοτny ^χ ^χ ποluchπvshiχ in eτο same vρemya πο 40 ιlg ne 100 g ποsοn body D / -valine '. , located in the sea.

Βο vτοροm οπvτe - κρysy-semtsn ηοροdy Βisτaρ (130-200 g), 9 and 9 κοnτροlny ^χ οπyτnyχ (60 mg D /) -vzlina 100 g weight τela).

Pοsle πρeκρascheniya 4 nedeliyχ administrations κοnτροlnmχ οnmτπy ^χ and ^χ zhivοτny οdnοκρaτnο and τοτalyyu οbsluchali on sτaτicheοκοm gemg.yu-τορe ^η οvτichesκοm aππaρaτe ΛGΛΤ-C (mοschnοsτ Ρ-ρa # 245 / min., ~ L ουl. = 2, 06 mπn ., D = 7.0 Gρ (equal to 730 Сο ⁶⁰ ) ^ Τ. Κ. Λ Д _Ι00 for κ н н ο 750 750 750 750 ^* ^ π и и и ο и и и и луч луч луч луч луч луч •; ¹² * Υ-ray of Сο ⁶⁰ ηρ and capacity 366-417 ρа # / min., That is the use we use - subtlety. For radiation protection, the proposed product (D-wave) judged the duration of hanging on the day ^χ ) of the original animal as compared with the consumer.

ΟShΤ I: 10 live animals in the middle lived Μ _0Ρβ = ΙΙ, Ι days

9 οπyτnyχ lived Μ _ητ - = 20,2 days (9-30) from κοτορy ^x οsτelοs in zhivyχ 4 zhnvοτnyχ (for sτaτ.οόρaόοτκi προdαlzhiτelnοsτ π ^χ life byηρι uslοvnο οbοznachena - 30 days) ρ.0,0Ι (ρaznitsa πο days surviving).

ΟShΤ П: 9 commercial living lived Μ = 12.4 (8-30), πз ι.οτορπχ survived I; 9 experienced 16.3 (9-30) lived, out of them 4 survived; Ρ-10,05 (more available).

Consequently, a long-lasting introduction of a lively blast causes a radiant effect that also results in a very good result.

0 in order to open up mechanisms for the adoption of adaptive influence on urbanism, it’s long ^{• •} .. "introduced D [ _> -value has been experimentally investigated.

According to the data received, it was established that a lengthy YUUDELI) daily, the introduction of the D-value, indicates:

I. The stimulating effect on the fear of the world is small. Well, there’s an increase ⁽ in nthe business of the state of the country), the level of the hemoglobin from (80-98) in the

up to 96.8 ⁽ 86-102 ⁾ in the event ⁽ ρ /, 0.05), quantity of eritists with _η U -4420000 13360000-4920000 ⁾ in the return for Μ ^ _τ , • = 4775000 ': (4560000-

5050000) in the case of (ρ /, 0.05) ^ the quantity of enterprises ⁽ in%) to D, 8 ^ 0.6-4.5) in comparison with the rate - 1.6 (ϊ, 3-2, ϊ) ρ ^ .0.05. 13. The current state of the land is at fault in the modernization of the city, which is deprived of the same, but also incidents. The gadgets for this are changing. Pροiοχοdyaτ τaιzhe n.zmοπenπya in sοsτοyanii belοy κροvιg.sshshenie segmenτοyadeρny ^χ ποIτροφπlyshχ leyκοtsiτοv and increase ^{κοlichοsτva;} shmfotsitov in ^η business hours. Pοvshιeιshe limφοtsiτοv svideτelsτvueτ ο ποvyshenii carried οts ^η ^η φi- chesκπχ lmmunnyχ ρeaκtsy in ορgashιzme zhπvοτnyχ in οsnοvnοm ze scheτ ροsτο κοlichesτva "bοlyππχ limφοtsiτοv ^and, τ.κ. οdnοvρemennο; in snvοροτκe κροvi eτiχ lsivοτnyχ προnsχοdiτ ηοvyshenie V -glοbu.schiyuv, η NMI οdutsiruemyχ .

2. Adversely affecting protein metabolism in the Russian society It causes a significant enelectic effect, which leads to an increase in the total increase in total weight in the entire territory of the country with) = 7.5 ⁽ 7.4 to 8). , ΟΙ in experience.

Costs and Absolute Amounts - Particularly

which is associated with the activation of ρ ш с ул ул ул ул,,,,, activation, with a real increase in the special immune response of an organism, i.e. Its resistance - to various adverse effects. Inebolic effect: it may also help to normalize the physical process

- - n. "

B .chιzποshyu vazhπy ορgana ^x ^x - PΘcheni, ηοchκaχ, seρdΘChϊyuy muscles l dρ. , more liable for the status of the white exchange in the Republic of Genocide is small.

3. Blagο ^η ρiyaτnοe vliyaiiο iοποsρedsτvοinο on x-y ^η muππuyu sisτe ορganizma mlenοπiτayuschiχ: ηρi οπρedelenπi sοsτοyannya ρseκtsππ sιl sτgρensφορmeιts- and ^η (IΤG) ηeρiφeρπchesκοi κροvi at οπyτnyχ and κοπτροlπm νπιvοτinχ bylz οbieρuzhena sποnτaineya (without shιτοgοnπyχ ^{'sτshdu-lyaτοροv)}

V лим ο ο ο эн эн лим φ φ и и и и лим ^" е е е е е е е е е е е •14. ug.povm at lively. Τaκ in κοnτροlyyuy gρuππe zhivοτny ^χ pοsle msslchποgο administration mο.ποκa summaρnyϋ% limφοblasτny ^χ κleτ.οκ sοstavlyal τοlκο 0.30 + 0.14, and in co-οπyτι gρuππe administration ποsle% -valine 4.61 + 1.13 πρi ρ = 0.002 (ρ difference of access).

Such stimulation leads to a high functional efficiency of the immune system. The same also claims that the data is available. Β limφaτichesκiχ uzlaχ and selezenκθ οπyτny ^χ κρeys in sρηvnenii with κοnτροlnymi vyyavlθny changes gοvορyaschie ο vyρazheπnοy ππg.ιushyui ρeaιschii κπeτοchnοgο τipa, οsuschesτvlyaemοy in οsnοvnοm Τ-limπ tsπτπmi-e-, e τaιote and οb aκτivaschzi immunnοy ρeeκschsh gummοροlnοgο τi ^η ο.

4. The activation of the system of the hyper-adrenal-protective shielding iron, which ensures a completely nonspecific increase in the incidence of the organism. small and good.

5. Impact on

Exchange, in order to prevent the occurrence of the manifestations of a mutable change in a heart-based system.

6. Pρedlagaemοe sρedsτvο q2 ~ velin, κaκ bylο usτeiοπlenο iρπ οgο biοlοgichesκi ^χ isπyτaniyaχ on zdοροvτχ zhπvοτnyχ, πρi pορορelnοm vvedeyush ηοlnοsτyu lishenο τοκsichesκnχ svοysτv, τ.κ. His LD is a real dose), even at the maximum possible amount of BBDSS.YURG material. Do not succeed.

The following is performed by the following:

Uchiτyveya nevοzmοzhnοsτ οπρedeliτ leτalnuyu dοzu D ^ -valpie, peρορelyyu vvοdimοgο eκsπeρimeiτelyιym zhivοτnym and τaκzhο φeκτ isποl-: -zοveπiya egο in sοsτave eminοκislοτnyχ mixtures πaρenτeρelyyugο ππτπiπya οnκοχiρuρgichesκiχ bοlnyχ πρi κοlichesτvennοm egο sοdeρzhasht 15 smeπi οτ 5 dο II suτκi g (50 κg weight of a person), which unconditionally proves it to be completely harmless and the value of human being see. Sujan Λ.Κ. in 15. in km. "Nutrition in the economy", Μ. Publishing House "United",

Τ.97, pp. 70-7ϊ), we found it possible to take advantage of it in person, i.e. on dοbροvοltsaχ - ηρaκτicheοκi zdοροvy ^χ lιsch iο sτρedeyuschπχ οτ cha.sτyχ ηροsτudnyχ zabοlevany, οτ vysοκοy φizichesκοi and umsτveshgoy uτοmlyaemοsτi and τaκzhe ιshegoschiχ ηρiznaκp nevροsτennchesκi ^χ οτgslοπenii in πsiχichesκοy deyaτelygosτi.

Synthetic amino acid D "-valine, flicker, kag. For the most part, it is described above by the strong and adaptive action of Yiu Ogaiism, which is small, for the person to use it in empirical way. suτοchnοy dοze οτ 0,250 dο 1,500 g zevnsimοsτi οτ vοzρηο vese .sτeηeni οslableniοsτi or chuvsτviτelygosτi ορganizema κ leκaρ- sτvοshιym vοzdeηsτviyam, sκlοnnοmτi κ giηvρτοnsh .. LΌ Pρed \ τe.gaemοe izοbρeτenie isηοlzοvali with uchasτiem persons - dοόροvοltsev following οbρazοm. The ideal daily access for children, children from 9 years of age, and also the elderly (after 70 years ^{), the} rate was slightly less than 0.2 (-2 or less ⁾ .

The daily dose for adults of women is from 0.500 g to 1,000 g of uterus and men is from 1,000 to 1.5000 g. In persons who are suffering from hypertension, there is no need to relieve pressure At this point, it follows sre.zu reduce to vulovpipi.

Κuρs πρiema πρedlagaemοgο sρedsτve sοsτavlyaeτ 2 months, ηz κοτορy ^x 1.5 month Sat weeks) πρnnimayuτ ezhednevnο ηοlnuyu suτοchnuyu dοzu, 7th ΗΘDΟLYU -. Th ^η οlοvinnuyu suτοchnuyu dοzu ezhednenο And ποslednyuyu <°) πθdθlyu - ποlοviniuyu suτοchnuyu dοzu chορez day τ.e Larger doses do not exist. 16._

It’s beneficial to take care of food and drink. Inappropriately unavailable non-existent processes in the human society in connection with the suspension of the load and the suspension of payments.

The proposed product is recommended to be disposed of in the first place after a full dispensation of one-half a day: (30-60 minutes before the day) or ππ π ο ο Ι сн сн))))) In the event of frequent insomnia, it is better to take a loss. If there is a loss of food, there is a daily / unnecessary daily loss of life, there is no need for it, but it may cause you to be injured.

The proposed invention is illustrated by the following products and equipment of new neighbors of the merchants. e>

I. The woman is 55 ^ leτ .Η.S.νποsτιslπmaκτeρichesκοm sοsτοyaπni, πeρiοdichesκi sτρadavsheya πρisτuηami glπeρτοnii, sτenοκaρdii, eleπenτοmi deπρessivnοgο sοsτοyaniya, neρvnοy sisτeι.sh, ποsτgρiπηοzπn οslοzhneniyami ρnniτ) shlevshaya izbyτοchny weight bysτρο uτοmlyavshayasya οτ umsτveshyuy and φizichesκοy ρabοτy.

It has been proposed that we offer an offer in the United States in 1992, in an actual dose of 0.500 g, we assume that a half of the price is low for the first day, it’s a long time ago. for 2 months, daily 0.5 g (without any direct absorption). Gosult..;

I. After 2 days of supplying pressure, we will fully alleviate the loss of pressure, which will remain unavailable for 19 days.

17.

2.. A miscarriage in the form of a non-existent matter is more significant.

3. The time has passed in the course of ηrphema and the gradual normalization of ischemic complications; There was a sense of convenience, a certain right-hand one. οτвθτ ne. All natural dischargers with impaired exposure.

4. After a gradual complication, the principle is at times very weak.

5. The restaurant is located only after the first visit to the club and without prior notice.

S. Οτmechaeτ znachiτelyyue ποvyυιenie φizichesκοy and uisτ ^η οchnοy ροbοτοsηοsοbnοsτi.

7, Gradually began to normalize the EU without the use of special diets for meals and meals.

P. 9 Ρebenοκ leτ (Τ.S.) sτρedavshy χροnichesκim φορπngiτοm, πο ^τ <.οτοροy πsιgaιchesκοy neuροvnοvesheshyusτyο οslablennye τορmοznyο iροiessn) chasτshln προsτudnsh.ιi zabοlevaiiyaιli (ρnιshτ, laρnignτ) οτsuτsτviem eηηeτiτa, asτθnichesιshm τiποm τelοslοzheniya, legκο vοzπiκeyuschim chuvsτvοm UΤΟΜLΘΗIYA at school.

After a 2-month reception, we offer an offer in March 1991 in the first daily dose 1 day 5) 0.250 mg a day for a little more than 12 days.

1. Diseases of the non-remnant area were eliminated.

2. Appeared and closed on the way to the sale of industrial processes: the operation is active, but it has been improved at the current time (game 1992).

3. There was a steady state of apriosis, but it appeared that the relationship was 2-3 days. He was not born, but he was not sick. 18. 4. Sense of fatigue disappeared because of the great activity, the academic year began and began the following. a year later ⁽ⁱⁿ spring 1992, I felt a little weakened in the first place that I had to regain my knowledge of the city)

PrPΟP'ϊ.

Kurus begins in the middle of May 1992 in the same dose. Over the month, with a substantial increase in amenity, it increased in weight, improved working ability and (child's activity).

1'ϊ. ΙLuyachshιe 64 gοda (Κ.S.Β.) sτρadavshy ηsiχichesκοy neuροvnο- vοiηπποsτyο ιshιmaκτeρichesκοgο ηροieχοzhdeniya ^(χ οsleblenie τορgyuzny schχlτοssοv, neadeκveτποeτ ρeaκtsii weak πsiχichesκie ρezdρηzhiτeln) παusτοϋchivοsτyο κ ηροsτudnym zabοlevaιshyam ⁽ⁱⁿ mοlοdοsτi neρeηes eκτπvnuyu (Τyuρ.τu τubeρκuleza) legκοy Tired of physical disruption and the manifestation of signs of increased obesity, excessive weight, ΗΠΟΤΟΗΗΠΟΤΟΗΗΠΟΤΟΗΗΠΟΤΟΗ.

The food was delivered in September-October 1991 in the early days before 5 days) 1,500 g in a warm morning at night, the sum of food in the courtyard - 75 g. Of the State:

I. The mental balance has ceased to manifest itself after a few months due to a new accident and lasted 1.5 months, but we are pleased to It was open for another 2 weeks (only kurus - ioyoyate ⁾ with a simple dose reduction. The home market has also been observed at present.

2. The whole winter-spring-spring season has not been followed by a single case of a fresh pastoral season.

3? Ч) 0 ДΘΒЗΗПЯ,

3. Pοsls ^η ροvedenπya κuρse πρiema iοvοgο sρedsτve ποyavnlηs ππαchπτelneya πzichesκeya aκτnvποsτ, οτsuτsτvie bysτροπ uτοmlyaemοsτη 19 "The best and the physical) in the industry.

4. Demonized, obesity to obesity has disappeared and is not present at present ⁽ after 7 months).

5. The disappearance of the signs of hypothesis. The action of the new product is offered by D 1 ”-valves. Possessing expressed edgatei properties without seasonal restrictions and without any accident. there was an apartment | ”on the 12th of December: men - 4, women - 7 (not more than 2 years old over 70 years old), children ⁽ 9 years old ⁾ - I.

Всеο all cases were observed; ηρezhde vsegο nορmalizatsiya nsiχichesκοgο sοsτοyaniya, dliτelyyu densτvuyuschοya ^(dο gοda) zπachlτelyyue improvement immunnοy zaschiτy ορganizma, vyρayaennοe sτοyκοe iοvyshenie φizichesκοy and umsτvennοy ρabοτοsηοsοbnοοτi and τayuκe ischeznοvenie πρiznaκοv neκοτορyχ χροnichesκiχ vοsπali- τelyshχ ηροtsessοv-s-gasτρiτοv ^(anatsidnyχ and giηeρatsidnyχ) χοletsπsτi τe, ΟΡ-ορganov observed. Also, the functionalism of the law ”is nothing, an intrinsic court system, and the normalization of general exchange (weight) _; "C ** yr * l""eπρ" ± "*." * L tsoo.ρs ^ ^^ gs.).

Τeχnichesκy ρezulτaτ ι.sηοlzοvaniya πρedlagaemοgο izοbρeτe ιιπya - nοvοgο sρedsτva, nesηetsiφichesκn ηοvyshayuschegο sοηροτivlyaemοοτ ορgaπizme, egο ρabοτοsηοsοbnοsτ and τaκzκe nορmelizuyuschego egο psιιχlchesκuιο deyaτelnοsτ, zaιslισchaeτsya in τοm ¹⁷ το πρedlηgaemοe sροdsτvο - sinτeτichesκaya eminοκislοτa D ϊ, - valine, being legκο iοluchaemym πuτem snnτeza dοsτuηnym In fact, there is a gain in the function of the human body, and there is no risk of personal injury. foreign restrictions on the adversarial activities of the other world, in the absence of other sources of edict. 20. .

Yaτο ποvοe προdlοgeeιdοe sρedsτvο mοlιeτ bττ shiροι.ο nsηοlzοgι ^η τ 'w ηροLnιlaκτiκi yizichesκοgο π ηsiχichesκοgο οzdοροvlenπya πaseleniya.

Π Disposal of non-profitable traffic (which is associated with accident * or is unavailable in the event of a hazardous condition.

Pοlneya bοzvρediοsτ πρedlοgaemοgο sρedsτvο dοκzzeπe προvedeπ- ττιnτi biοlοgichοsτ'lmi issledοveniyami ne zdοροvyχ shιvοτnnχ, α τοκzhβ ΟZΌ isnοlzοvaniem in κachesτve οdnοgο πz κοmποnenτοv emlnοκπslοτ- π ι Cíes for πeρenτeρalnοgο goιτeniya χiρuρgichesκiχ bοτgnπχ, gτ- (ylο ηοκezanο above.

Claims

-21-

^Γ ; Γ. ^P ΤΌΤ Ο лед з з з ο ο ο ϋ ϋ ϋ ϋ ϋ ϋ ϋ ϋ ^{• •}

The formula of the invention is a simple synergistic amino acid D | _g.v.ttn η as a part of the system, having the advantageous adaptive activity.