WO1993021980A1 - Dosage inhalator with indicating/interrupting means - Google Patents
Dosage inhalator with indicating/interrupting means Download PDFInfo
- Publication number
- WO1993021980A1 WO1993021980A1 PCT/SE1993/000389 SE9300389W WO9321980A1 WO 1993021980 A1 WO1993021980 A1 WO 1993021980A1 SE 9300389 W SE9300389 W SE 9300389W WO 9321980 A1 WO9321980 A1 WO 9321980A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- movement
- screw
- conduit
- carrying
- nut
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- the present invention relates to a dosage inhalator for dispensing to a patient a pharmacologically active compound or substance suspended in a fluid comprising a nozzle, a conduit connected to said nozzle, a storage means adjacent said conduit containing multiple doses of said active compound to be dispensed, a carrying means having portions for carrying predetermined and reproducible unit doses of said active compound, said carrying means being mounted for movement between said conduit and said storage means to position one of said portions in said conduit whereby said unit dose of said active compound located at said portion can be dispensed into the conduit said carrying menas being actuated by means of a maneuvering means.
- Dosage inhalators of the general type described above are disclosed for instance in US-A-4,524,769, which is directed towards a dosing means in a dosage inhalator, and US-A-4,668,218, which is directed towards a indicating means indicating the number of doses used or still remaining in a dosage dispensing means illustrated in an inhalator.
- a indicating means indicating the number of doses used or still remaining in a dosage dispensing means illustrated in an inhalator.
- it may however be advantageous that the patient is given a clear and unambiguous indication that the supply of the pharmacologically active compound is exhausted.
- an indicating means having a design which is simple and cheap to manufacture and which in a simple way can be set automatically to the actual number of doses filled into the dosage inhalator.
- said inhalator comprises means for disrupting the movement of said maneuvering means directly or indirectly upon exhaustion of said active compound in said storage means.
- the expression “disrupt” is used in the sense “to cause to break down”, for instance locking the maneuvering means or allowing the maneuvering means to rotate freely in one or both rotational directions. In this way the patient is given a clear indication that the supply of compound is exhausted.
- said inhalator is the providing of means or indicating either the number of doses remaining in said storage means or the number of doses used, said indicating means comprising a screw and nut mechanism being rotated by said intermittent movement of said carrying means, the relative movement between the screw and the nut in said mechanism being caused by said rotation being used for actuating said indicating means.
- the screw and nut mechanism preferably is provided with features for a quick adjustment in order to allow the indicating means to be preset easily to different numbers of doses.
- Fig 1 shows a longitudinal section through a first embodiment of the inhalator
- Fig 2 shows a partly sectioned longitudinal view of the inhalator shown in Fig 1
- Fig 3 shows a cross-section through the lower part of the inhalator in Fig 1,
- Fig 4 shows a longitudinal section through a second embodiment of the inhalator.
- the inhalator in a first embodiment comprises a housing 1 on which a nozzle 2 is mounted.
- the housing contains a conduit 3 for conducting ambient air through the housing to the nozzle 2 when the patient inhales through the inhalator.
- the housing further contains a storage chamber 4 for the micronized compound.
- the compound is transferred to the air conduit 3 from the storage chamber by means of a rotatable disc or membrane 5 containing conical holes 6.
- the disc 5 is mounted on a shaft 7 which is journalled in the housing 1.
- the under side of the disc 5 is provided with a ratchet wheel 8 cooperating with a pawl 9 attached to a rotatable maneuvering wheel 10 journalled onto the bottom of the housing 1.
- the movement of the maneuvering wheel 10 relative to the housing 1 is limited by means of a lever 11, which is attached to the wheel 10, and two stops in the form of projections 12, 13 extending downwards from the housing.
- the ratchet wheel 8 and consequently also the disc 5 When the wheel 10 is rotated in one direction from one limit to the other, the ratchet wheel 8, and consequently also the disc 5, will be rotated a distance which is determined by the distance between the stops 12, 13. When the maneuvering wheel is rotated in the other direction the ratchet wheel 8 and the disc 5 will remain stationary.
- the holes 6 are located in such a way on the disc that there always will be one or several holes 6 which will be located (and consequently will be filled) in the storage chamber 4 at the same time as one or several filled holes 6 are located in the air conduit 3 in one end position of the maneuvering wheel 10. This means that one movement of the maneuvering wheel 10 from one limit position to the other and back will ensure that there will be one or several filled holes 6 in the air conduit 3.
- the nozzle 2 may contain a deaggregating means 15 deaggregating any agglomerations that for instance may have formed when the micronized compound is filled into the holes 6.
- the housing also contains an indicating device in the form of a screw 16 and a nut means 17.
- the screw comprises two main parts 18 and 19.
- the upper flanks 21 of the threads form an oblique angle with the longitudinal direction of the screw whereas the lower flanks 22 of the threads are more or less perpendicularly oriented relative to the longitudinal direction of the screw 16.
- the nut means is in the form of a tip 17 attached to a resilient arm 20 slideably supported in a guide 23 on the inner wall of the housing 1. In the initial position the major part of the arm 20 extends out from the guide 23.
- the under side of the tip 17 is oriented to be generally parallel to the upper flanks of the threads and the upper side of the tip 17 is oriented to be generally in parallel to the lower flank of the threads. This results in that the arm 20 and the tip 17 can be slid along the screw in the manner of a ratchet mechanism to any desired position along the upper part of the screw. The tip will however move downwards with the rotation of the screw from any such position.
- the upper part 18 of the screw 16 is generally cylindrical, whereas the lower part 19 is conical in shape.
- the pitch of the threads on the cylindrical part 18 of the screw 16 is much finer than the pitch of the threads on the conical part 19.
- the upper part of the arm 20 is initially bent inwards, by which means the tip 17 is spring-biased towards the threads of the screw 16.
- the lower end of the screw 16 is provided with cogs 24 which are engagement with cogs 25 on the shaft 7 by means of an intermediate cogwheel 26.
- a rotation of the disc 5 consequently will result in a rotation of the screw 16 entailing a downward movement of the arm 20.
- the outer side of the arm 20 is provided with a scale indicating the number of doses still remaining which is visible through a window in the housing provided with an index 27.
- a visual indication that the supply of the compound is close to be exhausted can be obtained in that the window is designed with a length which is sufficient to allow the screw to be seen above the arm when the arm comes close to its lower end position.
- the screw preferably should be made of brightly colored material to indicate exhaustion of available doses.
- the lower end 28 of the arm 20 is oriented obliquely relative to the longitudinal direction of the inhalator.
- the guide 23 is located just before the stop 12 limiting the movement of the lever 11, as seen in the direction of movement of the lever 11 towards the stop 12.
- a cut out portion 29 in the lower edge of the wall of the housing 1 having a width corresponding to the width of the lever 11 is located adjacent the stop 12 after the stop 12.
- the nut or tip 17 is located above the threads of the screw 16.
- the function of the dosing disc and its associated mechanisms can be tested in conjunction with the manufacture of and before the filling of the inhalator without actuating the indicating means.
- the tip 17 is pushed into engagement with the threads of the screw 16. If the full amount of micronized compound possible is to be filled into the storage chamber, the tip 17 is merely pushed downwards into engagement with the uppermost of the threads and the maximum number of doses will be visible in the window. Should it be desirable to fill a smaller amount of micronized powder (i.e.
- the tip 17 is slid further downwards over the threads, a smaller number of doses then being indicated in the window.
- This movement of the tip 17 can be performed automatically by means of pins of different lengths which are inserted through a hole in the upper wall of the housing directly above the guide 23, this preferably in conjunction with the filling of the inhalator.
- the arm 20 will move downwards at a constant rate in conjunction with the rotation of the disc 5 as long as the tip 17 is located on the upper part 18 of the screw 16.
- the tip 17 reaches the conical part 19 of the screw, the downward movement of the tip will accelerate due to the much coarser pitch of the threads on this part and the lower end 28 of the arm 20 will move relatively fast into the path of the lever 11.
- the lower end 28 of the arm 20 will function as a slideway for the resilient lever 11 which by this means is lifted over the stop 12 and snaps down into the cut out portion 29 behind the stop 12.
- the lever can be locked in either the loading or the dispensing position of the carrying means depending on the location of the cut out portion 29.
- FIG. 4 An alternative embodiment of the inhalator is shown in Fig 4.
- the reference signs for parts in Fig 4 being similar to parts in Figs 1 - 3 differ from the reference signs relating to Figs 1 - 3 only in that they are numbered from 100 and upwards. Only the parts being necessary for the understanding of the differences between the two embodiments will be described in connection with Fig 4.
- the shaft 107 mounting the rotatable disc 105 is shaped as a hollow sleeve containing the screw 116.
- the threads on the screw 116 have the same general shape as the threads in the above embodiment although they may have the same pitch over the entire length of the screw.
- the screw 116 will be oriented upside down relative to the screw 16 in Figs 1 - 3, the sloping flanks of the threads will be facing downwards.
- the arm 120 is shaped as a resilient tongue cut longitudinally in the wall of the sleeve 107 with the free end facing downwards and carrying the nut means in the form of a tip 117 projecting into the interior of the sleeve 107.
- the tip 117 has the general shape of the tip 17 in the above embodiment but is also turned upside down in relation to the tip 17.
- the pitch of the screw is chosen such that the screw will move downwards when the disc 105 is rotated by means of the ratchet mechanism 108, 109.
- the screw thus can be pushed down to a desired position corresponding to a predetermined number of doses in a manner similar to the one of the nut means above. The screw will then move downwards from that position when the disc 105 is rotated.
- the indicating means are in the form of a bar 132 carrying a scale showing the number of remaining doses through a window 133 and being slideable in a longitudinal guide 123 arranged on the inside of the wall of the housing 101.
- the bar 132 is rigidly connected to the screw 116 by means of an intermediate bar 131 and will consequently move with the longitudinal movements of the screw 116.
- the screw 116 will move downwards for each rotational movement of the disc 105.
- the lower end of the screw 116 will engage the resilient lever 111 bending the lever downwards.
- the well-defined rotational reciprocal movement of the maneuvering means between two end positions indicate normal movement of said carrying means in connection with dispensing a unit dose into said conduit.
- the device according to the invention will drastically alter this regularity of the movement, either by locking the maneuvering means or by eliminating one or both of the two end positions of the maneuvering means.
- maneuvering means and the carrying means in the above pre erred embodiments have been illustrated as being two separate parts, it of course also is conceivable to design the maneuvering means as an integral part of the carrying means, e.g. as a knurled portion of the carrying means extending through a slot in the housing.
- the scale is located on the housing and the index on the resilient arm 20.
- the scale can of course be located on hte resilient arm and the index on the housing.
- Another possible modification of the dosage inhalator according to the invention is to arrange the threads on the respective component in said screw and nut mechanism in a manner to allow them to be disengaged from each other in order to permit said translational movement.
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR9306323A BR9306323A (en) | 1992-05-05 | 1993-05-04 | Dosage inhaler to provide a patient with a pharmacologically active compound suspended in a fluid |
DE69325722T DE69325722T2 (en) | 1992-05-05 | 1993-05-04 | DOSING INHALATOR WITH DISPLAY / INTERRUPTION DEVICE |
AU40310/93A AU669708B2 (en) | 1992-05-05 | 1993-05-04 | Dosage inhalator with indicating/interrupting means |
DK93909561T DK0682539T3 (en) | 1992-05-05 | 1993-05-04 | Dosing Inhalator with indicating / interrupting means |
SK1328-94A SK132894A3 (en) | 1992-05-05 | 1993-05-04 | Dosage inhalator with indicating interrupting means |
JP51919193A JP3423714B2 (en) | 1992-05-05 | 1993-05-04 | Drug inhaler |
EP93909561A EP0682539B1 (en) | 1992-05-05 | 1993-05-04 | Dosage inhalator with indicating/interrupting means |
CA002134562A CA2134562C (en) | 1992-05-05 | 1993-05-04 | Dosage inhalator with indicating/interrupting means |
US08/331,589 US5549101A (en) | 1992-05-05 | 1993-05-04 | Dosage inhalator with indicating/interrupting means |
NO944059A NO944059D0 (en) | 1992-05-05 | 1994-10-25 | Dose inhaler with indicating / interrupting means |
FI945208A FI945208A (en) | 1992-05-05 | 1994-11-04 | Dosing nebuliser with indicating / cutting means |
HK98111259A HK1010346A1 (en) | 1992-05-05 | 1998-10-15 | Dosage inhalator with indicating/interrupting means |
GR990402622T GR3031535T3 (en) | 1992-05-05 | 1999-10-14 | Dosage inhalator with indicating/interrupting means. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9201411A SE9201411D0 (en) | 1992-05-05 | 1992-05-05 | DOSAGE INHALATOR WITH INDICATING / INTERUPTING MEANS |
SE9201411-7 | 1992-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993021980A1 true WO1993021980A1 (en) | 1993-11-11 |
Family
ID=20386149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1993/000389 WO1993021980A1 (en) | 1992-05-05 | 1993-05-04 | Dosage inhalator with indicating/interrupting means |
Country Status (23)
Country | Link |
---|---|
US (1) | US5549101A (en) |
EP (1) | EP0682539B1 (en) |
JP (1) | JP3423714B2 (en) |
AT (1) | ATE182272T1 (en) |
AU (1) | AU669708B2 (en) |
BR (1) | BR9306323A (en) |
CA (1) | CA2134562C (en) |
CZ (1) | CZ268994A3 (en) |
DE (1) | DE69325722T2 (en) |
DK (1) | DK0682539T3 (en) |
EE (1) | EE02975B1 (en) |
ES (1) | ES2134845T3 (en) |
FI (1) | FI945208A (en) |
GR (1) | GR3031535T3 (en) |
HK (1) | HK1010346A1 (en) |
HU (1) | HUT70124A (en) |
IS (1) | IS4016A (en) |
NZ (1) | NZ251915A (en) |
RU (1) | RU94046019A (en) |
SE (1) | SE9201411D0 (en) |
SG (1) | SG52375A1 (en) |
SK (1) | SK132894A3 (en) |
WO (1) | WO1993021980A1 (en) |
Cited By (10)
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WO1997024586A1 (en) * | 1995-12-28 | 1997-07-10 | Boehringer Ingelheim International Gmbh | Mechanical counter for a metering apparatus |
US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
EP0916356A3 (en) * | 1997-11-12 | 2000-03-01 | Miat S.P.A. | Dose dispenser for substances in powder or granular form |
WO2004024340A1 (en) * | 2002-08-28 | 2004-03-25 | Boehringer Ingelheim International Gmbh | Blocking device for a sprung lock with a spring operation |
US7396341B2 (en) | 2002-08-28 | 2008-07-08 | Boehringer Ingelheim International Gmbh | Blocking device for a locking stressing mechanism having a spring-actuated output drive device |
US8459253B2 (en) | 2007-04-02 | 2013-06-11 | 3M Innovative Properties Company | Dose counter |
WO2014016563A1 (en) * | 2012-07-23 | 2014-01-30 | Sheffield Hallam University | Powder discharge gun |
DE102015119617A1 (en) | 2015-11-13 | 2017-05-18 | Alfred Von Schuckmann | Hand-operated inhaler |
EA027216B1 (en) * | 2009-07-30 | 2017-07-31 | Ивакс Интернэшнл Б.В. | Dose counter for a metered-dose inhaler |
WO2020064343A1 (en) * | 2018-09-27 | 2020-04-02 | Shl Medical Ag | Locking mechanism for an aerosol dispenser |
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US7131441B1 (en) | 1995-12-07 | 2006-11-07 | Skyepharma Ag | Inhaler for multiple dosed administration of a pharmacological dry powder |
ES2216418T3 (en) * | 1995-12-07 | 2004-10-16 | Jago Research Ag | NOZZLE FOR AN INHALER FOR THE ADMINISTRATION OF VARIOUS DOSE OF A DRY PHARMACOLOGICAL POWDER. |
ATE216903T1 (en) | 1996-02-21 | 2002-05-15 | Schering Corp | INHALER FOR POWDER-TYPE MEDICATION |
SE9700938D0 (en) * | 1997-03-14 | 1997-03-14 | Astra Ab | Powder inhaler II and a method of construction thereof |
SE9700940D0 (en) * | 1997-03-14 | 1997-03-14 | Astra Ab | Powder inhales IV |
US5871007A (en) * | 1997-06-09 | 1999-02-16 | Chase Marketing International L.L.C. | Throat spray counting mechanism |
NZ504021A (en) * | 1997-10-17 | 2003-04-29 | Systemic Pulmonary Delivery Lt | Method and apparatus for delivering aerosolized medication having air discharged through air tube directly into plume of aerosolized medication |
US6142339A (en) | 1998-01-16 | 2000-11-07 | 1263152 Ontario Inc. | Aerosol dispensing device |
WO1999036115A2 (en) | 1998-01-16 | 1999-07-22 | 1263152 Ontario Inc. | Indicating device for use with a dispensing device |
US6082358A (en) | 1998-05-05 | 2000-07-04 | 1263152 Ontario Inc. | Indicating device for aerosol container |
US6729330B2 (en) | 1998-05-05 | 2004-05-04 | Trudell Medical International | Indicating device for aerosol container |
US6336453B1 (en) | 1999-04-30 | 2002-01-08 | Trudell Medical International | Indicating device for aerosol container |
ES2272252T3 (en) * | 1999-01-14 | 2007-05-01 | Teijin Limited | DEVICE FOR MANAGING A CONSTANT AMOUNT OF A POWDER BODY. |
GB0004456D0 (en) * | 2000-02-26 | 2000-04-19 | Glaxo Group Ltd | Medicament dispenser |
GB2360218A (en) * | 2000-03-18 | 2001-09-19 | Astrazeneca Uk Ltd | Inhaler |
FI20000810A0 (en) * | 2000-04-06 | 2000-04-06 | Orion Yhtymae Oyj | The powder inhaler |
GB0012465D0 (en) * | 2000-05-24 | 2000-07-12 | Glaxo Group Ltd | Monitoring method |
GB0013619D0 (en) * | 2000-06-06 | 2000-07-26 | Glaxo Group Ltd | Sample container |
PE20020074A1 (en) | 2000-06-23 | 2002-02-05 | Norton Healthcare Ltd | DOSING SYSTEM FOR MEDICATION INHALER |
JP2004503338A (en) * | 2000-07-15 | 2004-02-05 | グラクソ グループ リミテッド | Drug removal device |
US6745760B2 (en) | 2001-05-15 | 2004-06-08 | Trudell Medical International | Medicament applicator |
US7004164B2 (en) | 2002-03-21 | 2006-02-28 | Trudell Medical International | Indicating device for aerosol container |
WO2003080161A1 (en) | 2002-03-22 | 2003-10-02 | Clinical Designs Limited | Can fixture |
GB0304000D0 (en) * | 2003-02-21 | 2003-03-26 | Clinical Designs Ltd | Dispenser |
US7621273B2 (en) | 2003-10-28 | 2009-11-24 | Trudell Medical International | Indicating device with warning dosage indicator |
GB0327112D0 (en) * | 2003-11-21 | 2003-12-24 | Clincial Designs Ltd | Dispenser and reservoir |
GB0328859D0 (en) | 2003-12-12 | 2004-01-14 | Clinical Designs Ltd | Dispenser and counter |
US7100530B2 (en) | 2003-12-15 | 2006-09-05 | Trudell Medical International, Inc. | Dose indicating device |
US7543582B2 (en) | 2004-09-20 | 2009-06-09 | Trudell Medical International | Dose indicating device with display elements attached to container |
GB0425518D0 (en) | 2004-11-19 | 2004-12-22 | Clinical Designs Ltd | Substance source |
GB0428204D0 (en) | 2004-12-23 | 2005-01-26 | Clinical Designs Ltd | Medicament container |
WO2006077486A1 (en) | 2005-01-20 | 2006-07-27 | Trudell Medical International | Dispensing device |
JP4711286B2 (en) * | 2005-03-31 | 2011-06-29 | 株式会社吉野工業所 | Suction powder dispenser |
GB0518400D0 (en) | 2005-09-09 | 2005-10-19 | Clinical Designs Ltd | Dispenser |
US8141550B2 (en) | 2006-08-01 | 2012-03-27 | Trudell Medical International | Dispensing device |
US8082873B2 (en) | 2008-05-05 | 2011-12-27 | Trudell Medical International | Drive mechanism for an indicating device |
US8181591B1 (en) | 2008-05-23 | 2012-05-22 | Trudell Medical International | Domed actuator for indicating device |
WO2010008523A1 (en) | 2008-07-13 | 2010-01-21 | Map Pharmaceuticals, Inc. | Methods and apparatus for delivering aerosolized medication |
ES2402241T3 (en) | 2008-10-22 | 2013-04-30 | Trudell Medical International | Modular Spray Supply System |
GB0904040D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
GB0904059D0 (en) | 2009-03-10 | 2009-04-22 | Euro Celtique Sa | Counter |
GB201115874D0 (en) * | 2011-09-14 | 2011-10-26 | Astrazeneca Ab | Inhaler |
US9871499B2 (en) | 2013-03-15 | 2018-01-16 | Qorvo Us, Inc. | Multi-band impedance tuners using weakly-coupled LC resonators |
ES2874029T3 (en) * | 2014-05-07 | 2021-11-04 | Boehringer Ingelheim Int | Nebulizer |
BR112017001414A2 (en) * | 2014-07-22 | 2017-11-21 | Panjabi Akshay | dose counting mechanism |
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GB2041763A (en) * | 1979-02-05 | 1980-09-17 | Chiesi P | An inhalor for pulverulent medicinal substances |
US4524769A (en) * | 1981-07-08 | 1985-06-25 | Aktiebolaget Draco | Dosage inhalator |
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WO1992000771A1 (en) * | 1990-07-13 | 1992-01-23 | Innovata Biomed Limited | Inhaler |
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1992
- 1992-05-05 SE SE9201411A patent/SE9201411D0/en unknown
-
1993
- 1993-05-04 CA CA002134562A patent/CA2134562C/en not_active Expired - Lifetime
- 1993-05-04 IS IS4016A patent/IS4016A/en unknown
- 1993-05-04 AU AU40310/93A patent/AU669708B2/en not_active Expired
- 1993-05-04 AT AT93909561T patent/ATE182272T1/en active
- 1993-05-04 HU HU9403180A patent/HUT70124A/en unknown
- 1993-05-04 NZ NZ251915A patent/NZ251915A/en unknown
- 1993-05-04 SG SG1996003664A patent/SG52375A1/en unknown
- 1993-05-04 DE DE69325722T patent/DE69325722T2/en not_active Expired - Lifetime
- 1993-05-04 JP JP51919193A patent/JP3423714B2/en not_active Expired - Lifetime
- 1993-05-04 EP EP93909561A patent/EP0682539B1/en not_active Expired - Lifetime
- 1993-05-04 RU RU94046019/14A patent/RU94046019A/en unknown
- 1993-05-04 CZ CZ942689A patent/CZ268994A3/en unknown
- 1993-05-04 SK SK1328-94A patent/SK132894A3/en unknown
- 1993-05-04 WO PCT/SE1993/000389 patent/WO1993021980A1/en active IP Right Grant
- 1993-05-04 BR BR9306323A patent/BR9306323A/en not_active Application Discontinuation
- 1993-05-04 US US08/331,589 patent/US5549101A/en not_active Expired - Lifetime
- 1993-05-04 ES ES93909561T patent/ES2134845T3/en not_active Expired - Lifetime
- 1993-05-04 DK DK93909561T patent/DK0682539T3/en active
-
1994
- 1994-11-04 FI FI945208A patent/FI945208A/en not_active Application Discontinuation
- 1994-11-08 EE EE9400303A patent/EE02975B1/en unknown
-
1998
- 1998-10-15 HK HK98111259A patent/HK1010346A1/en not_active IP Right Cessation
-
1999
- 1999-10-14 GR GR990402622T patent/GR3031535T3/en unknown
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WO1992000771A1 (en) * | 1990-07-13 | 1992-01-23 | Innovata Biomed Limited | Inhaler |
Cited By (23)
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Also Published As
Publication number | Publication date |
---|---|
CZ268994A3 (en) | 1995-02-15 |
ES2134845T3 (en) | 1999-10-16 |
EE02975B1 (en) | 1997-04-15 |
AU4031093A (en) | 1993-11-29 |
HU9403180D0 (en) | 1995-02-28 |
GR3031535T3 (en) | 2000-01-31 |
CA2134562A1 (en) | 1993-11-11 |
DE69325722T2 (en) | 2000-02-10 |
HK1010346A1 (en) | 1999-06-17 |
BR9306323A (en) | 1998-06-30 |
SE9201411D0 (en) | 1992-05-05 |
CA2134562C (en) | 2003-04-08 |
SG52375A1 (en) | 1998-09-28 |
AU669708B2 (en) | 1996-06-20 |
FI945208A0 (en) | 1994-11-04 |
EP0682539B1 (en) | 1999-07-21 |
RU94046019A (en) | 1996-09-20 |
NZ251915A (en) | 1996-02-27 |
US5549101A (en) | 1996-08-27 |
JPH07506031A (en) | 1995-07-06 |
JP3423714B2 (en) | 2003-07-07 |
DE69325722D1 (en) | 1999-08-26 |
DK0682539T3 (en) | 1999-11-29 |
ATE182272T1 (en) | 1999-08-15 |
EP0682539A1 (en) | 1995-11-22 |
FI945208A (en) | 1994-11-04 |
IS4016A (en) | 1993-11-06 |
HUT70124A (en) | 1995-09-28 |
SK132894A3 (en) | 1995-06-07 |
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