WO1992018197A1 - Device for carrying out an iontophoresis treatment on a patient - Google Patents
Device for carrying out an iontophoresis treatment on a patient Download PDFInfo
- Publication number
- WO1992018197A1 WO1992018197A1 PCT/NL1992/000077 NL9200077W WO9218197A1 WO 1992018197 A1 WO1992018197 A1 WO 1992018197A1 NL 9200077 W NL9200077 W NL 9200077W WO 9218197 A1 WO9218197 A1 WO 9218197A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- patient
- signal
- treatment signal
- duty cycle
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Definitions
- the invention relates to a device for carrying out an iontophoresis treatment on a patient, provided with a signal generator for generating a treatment signal and an output stage which can be connected to the patient by means of two electrodes.
- Such devices are known in various embodiments. With the aid of an iontophoresis treatment, it is pos- sible to introduce electrically charged particles into a patient's body by means of the treatment signal. In this way it is possible to introduce a drug locally into the body. Under these circumstances, the guantity of sub ⁇ stance introduced into the body is essentially propor- tional to the product of the treatment current and the time. In the standard devices of this type, various kinds of treatment signals are used but they all have disadvantages.
- a known treatment signal is formed by an uninter- rupted direct current, which has the drawback that a severe burning sensation is induced in the patient by this current form, which can very rapidly result in cauterisation of the patient's skin, either over a large area under the entire electrode or as a local so-called point cauterisation.
- the maximum permissible current density of the treatment signal is very low and in practice it is assumed that a maximum value of 0.2 mA/cm 2 is still safe.
- the treatment signal in this form causes such a high skin stress that a daily repetition of the treatment is virtually ruled out.
- Another known treatment signal is formed by a pulse current in the form of a half-wave or full-wave rectified sinusoidal signal, which also has the drawback that a burning sensation can be induced in the patient and cauterisation of the skin also occurs.
- the duty cycle of said signal is appreciably less than 100%, as a result of which a relatively small guantity of substance can be introduced into the body per unit time, with the result that a longer treatment time is necessary and, consequently, a high skin stress occurs again.
- the treatment signal in this form has the drawback that such current forms are usually also used for other therapies, with the result that a combination effect occurs, the consequences of which are incalculable.
- a device is also known in which a treatment signal is generated which comprises a depolari ⁇ sing alternating current which is made up of a positive pulse and a smaller negative pulse or vice versa.
- the duty cycle of this treatment signal is appreciably less than 100%, as a result of which long treatment times and high current densities are necessary.
- the negative pulse would result in an inverse effect to the positive pulse, thereby reducing the efficiency of the treatment further.
- the object of the invention is to provide a device of the type mentioned in the introduction, in which the disadvantages mentioned are eliminated in a simple and expedient manner.
- the device according to the invention has the characteristic that the signal gen ⁇ erator generates as treatment signal a pulsed direct current with a duty cycle of at least 80%.
- a device is obtained which makes possible a particularly expedient iontophoresis treatment of the patient, with a high efficiency for the introduc ⁇ tion of the substance being achieved by the relatively high duty cycle.
- the treatment signal generated by the device according to the invention does not induce any burning sensation in the patient, with the result that a relatively high current density can be used and, consequently, more substance can be introduced in the same treatment time. In practical tests it has been found that no cauterisation of the skin occurs. As a result of the low skin stress, the patient can be treated regularly, if necessary daily.
- Figure 1 is a highly simplified block diagram of an embodiment of the device according to the invention.
- Figure 2 shows the current form of the treatment signal of the device according to Figure 1.
- Figure 1 shows a highly simplified block diagram of a device for carrying out an iontophoresis treatment on a patient, which device is provided with a signal generator 1 for generating a treatment signal and an output stage 2 which can be connected to the patient by means of two diagrammatically indicated electrodes 3.
- the output of the output stage 2 is designed as a current source.
- the treatment signal generated by the signal generator 1 is a pulsed direct current or rectangular pulse train, the on/off ratio or duty cycle of the signal per cycle being very high, that is to say at least 80%.
- the current density, the frequency and the duty cycle of the treatment signal can be set by means of a suitable setting device 4, 5 or 6, respectively.
- the duty cycle can preferably be set between 90 and 98%. Satisfactory treatment results can already be achieved with a duty cycle of at least 80%.
- the frequency of the treatment signal can be set by means of the setting device 5 to a value upwards of at least 1 kHz and is preferably set in the region of 4-8 kHz.
- the current density of the treatment signal can, without difficulty, be set a factor of 5 or more higher than in the known device, that is to say to a value of 1 mA/cm 2 or higher.
- the treatment signal in this form has important advantages.
- the duty cycle can be very high, in the region of 90-98%, as a result of which a high efficiency is achieved in the introduction of substances into the body by means of the treatment. No burning sensation occurs in the patient, with the result that high current densities can be used, as a result of which more drug can be introduced into the patient in a certain treatment period than is possible in the case of the known device. Tests have shown that no cauterisation of the skin occurs. As a result, the treatment can be carried out much more frequently, if necessary even daily.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92909753A EP0537320B1 (en) | 1991-04-17 | 1992-04-15 | Device for carrying out an iontophoresis treatment on a patient |
DE69201850T DE69201850T2 (en) | 1991-04-17 | 1992-04-15 | DEVICE FOR CARRYING OUT AN IONTOPHORETIC TREATMENT ON A PATIENT. |
JP4509298A JPH06503496A (en) | 1991-04-17 | 1992-04-15 | Device for treating patients with iontophoresis |
US07/962,196 US5391195A (en) | 1991-04-17 | 1992-04-15 | Device for carrying out an iontophoresis treatment on a patient |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL9100662 | 1991-04-17 | ||
NL9100662A NL9100662A (en) | 1991-04-17 | 1991-04-17 | DEVICE FOR PERFORMING AN ITHOPHORESIS TREATMENT ON A PATIENT. |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992018197A1 true WO1992018197A1 (en) | 1992-10-29 |
Family
ID=19859142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL1992/000077 WO1992018197A1 (en) | 1991-04-17 | 1992-04-15 | Device for carrying out an iontophoresis treatment on a patient |
Country Status (9)
Country | Link |
---|---|
US (1) | US5391195A (en) |
EP (1) | EP0537320B1 (en) |
JP (1) | JPH06503496A (en) |
AT (1) | ATE120378T1 (en) |
DE (1) | DE69201850T2 (en) |
DK (1) | DK0537320T3 (en) |
ES (1) | ES2072761T3 (en) |
NL (1) | NL9100662A (en) |
WO (1) | WO1992018197A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040365A1 (en) * | 1995-06-07 | 1996-12-19 | Alza Corporation | Electrotransport agent delivery method and apparatus |
WO1999030775A1 (en) * | 1997-12-17 | 1999-06-24 | Alza Corporation | Iontophoresis with programmed adjustment of electric current |
AU710793B2 (en) * | 1995-06-07 | 1999-09-30 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US6496728B2 (en) | 2000-02-18 | 2002-12-17 | University Of Utah Research Foundation | Methods for extracting substances using alternating current |
US6512950B2 (en) | 2000-02-18 | 2003-01-28 | University Of Utah Research Foundation | Methods for delivering agents using alternating current |
US7136698B2 (en) | 1996-06-07 | 2006-11-14 | Alza Corporation | Electrotransport agent delivery apparatus |
US7137975B2 (en) | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6956032B1 (en) * | 1986-04-18 | 2005-10-18 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
US5676648A (en) | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
US6385487B1 (en) | 1996-05-08 | 2002-05-07 | Biophoretic Therapeutic Systems, Llc | Methods for electrokinetic delivery of medicaments |
USRE37796E1 (en) | 1997-12-16 | 2002-07-23 | Biophoretic Therapeutic Systems, Llc | Methods for iontophoretic delivery of antiviral agents |
US6148231A (en) * | 1998-09-15 | 2000-11-14 | Biophoretic Therapeutic Systems, Llc | Iontophoretic drug delivery electrodes and method |
US6792306B2 (en) * | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
US7127285B2 (en) * | 1999-03-12 | 2006-10-24 | Transport Pharmaceuticals Inc. | Systems and methods for electrokinetic delivery of a substance |
US6477410B1 (en) * | 2000-05-31 | 2002-11-05 | Biophoretic Therapeutic Systems, Llc | Electrokinetic delivery of medicaments |
US6553255B1 (en) | 2000-10-27 | 2003-04-22 | Aciont Inc. | Use of background electrolytes to minimize flux variability during iontophoresis |
US20030065285A1 (en) * | 2001-07-23 | 2003-04-03 | Higuchi William I. | Method and apparatus for increasing flux during reverse iontophoresis |
US20060254912A1 (en) * | 2003-03-04 | 2006-11-16 | Amos Nussinovitch | System and method for treating biological tissue usiing curret electrical field |
JP2020137721A (en) * | 2019-02-27 | 2020-09-03 | パナソニックIpマネジメント株式会社 | Cosmetic device, and control unit of the same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4116238A (en) * | 1976-08-18 | 1978-09-26 | Midgard Electronics Company, Inc. | High voltage constant current source for iontophoresis |
US4167190A (en) * | 1977-10-21 | 1979-09-11 | Medtronic, Inc. | Pulse dosage control unit for tissue stimulation system |
US4340047A (en) * | 1978-10-18 | 1982-07-20 | Robert Tapper | Iontophoretic treatment apparatus |
EP0308572A2 (en) * | 1983-09-01 | 1989-03-29 | Hisamitsu Pharmaceutical Co., Inc. | An iontophoresis device |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3991755A (en) * | 1973-07-27 | 1976-11-16 | Medicon, Inc. | Iontophoresis apparatus for applying local anesthetics |
US4019510A (en) * | 1975-02-10 | 1977-04-26 | Sybron Corporation | Therapeutic method of using low intensity direct current generator with polarity reversal |
US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
US5088977A (en) * | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
US5047007A (en) * | 1989-12-22 | 1991-09-10 | Medtronic, Inc. | Method and apparatus for pulsed iontophoretic drug delivery |
-
1991
- 1991-04-17 NL NL9100662A patent/NL9100662A/en not_active Application Discontinuation
-
1992
- 1992-04-15 AT AT92909753T patent/ATE120378T1/en active
- 1992-04-15 EP EP92909753A patent/EP0537320B1/en not_active Expired - Lifetime
- 1992-04-15 DK DK92909753.3T patent/DK0537320T3/en active
- 1992-04-15 JP JP4509298A patent/JPH06503496A/en active Pending
- 1992-04-15 ES ES92909753T patent/ES2072761T3/en not_active Expired - Lifetime
- 1992-04-15 US US07/962,196 patent/US5391195A/en not_active Expired - Fee Related
- 1992-04-15 WO PCT/NL1992/000077 patent/WO1992018197A1/en active IP Right Grant
- 1992-04-15 DE DE69201850T patent/DE69201850T2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4116238A (en) * | 1976-08-18 | 1978-09-26 | Midgard Electronics Company, Inc. | High voltage constant current source for iontophoresis |
US4167190A (en) * | 1977-10-21 | 1979-09-11 | Medtronic, Inc. | Pulse dosage control unit for tissue stimulation system |
US4340047A (en) * | 1978-10-18 | 1982-07-20 | Robert Tapper | Iontophoretic treatment apparatus |
EP0308572A2 (en) * | 1983-09-01 | 1989-03-29 | Hisamitsu Pharmaceutical Co., Inc. | An iontophoresis device |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
WO1996040364A1 (en) * | 1995-06-07 | 1996-12-19 | Alza Corporation | Electrotransport agent delivery method and apparatus |
AU694371B2 (en) * | 1995-06-07 | 1998-07-16 | Alza Corporation | Electrotransport agent delivery method and apparatus |
AU701238B2 (en) * | 1995-06-07 | 1999-01-21 | Alza Corporation | Electrotransport agent delivery method and apparatus |
AU710793B2 (en) * | 1995-06-07 | 1999-09-30 | Alza Corporation | Electrotransport agent delivery method and apparatus |
WO1996040365A1 (en) * | 1995-06-07 | 1996-12-19 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US7212853B1 (en) | 1995-06-07 | 2007-05-01 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US7136698B2 (en) | 1996-06-07 | 2006-11-14 | Alza Corporation | Electrotransport agent delivery apparatus |
WO1999030775A1 (en) * | 1997-12-17 | 1999-06-24 | Alza Corporation | Iontophoresis with programmed adjustment of electric current |
US6219576B1 (en) | 1997-12-17 | 2001-04-17 | Alza Corporation | Programmed adjustment of electric current to provide desired electrically assisted transdermal drug delivery rate |
US6496728B2 (en) | 2000-02-18 | 2002-12-17 | University Of Utah Research Foundation | Methods for extracting substances using alternating current |
US6512950B2 (en) | 2000-02-18 | 2003-01-28 | University Of Utah Research Foundation | Methods for delivering agents using alternating current |
US7137975B2 (en) | 2001-02-13 | 2006-11-21 | Aciont, Inc. | Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent |
Also Published As
Publication number | Publication date |
---|---|
ES2072761T3 (en) | 1995-07-16 |
NL9100662A (en) | 1992-11-16 |
EP0537320B1 (en) | 1995-03-29 |
DE69201850D1 (en) | 1995-05-04 |
US5391195A (en) | 1995-02-21 |
DE69201850T2 (en) | 1995-11-09 |
JPH06503496A (en) | 1994-04-21 |
ATE120378T1 (en) | 1995-04-15 |
EP0537320A1 (en) | 1993-04-21 |
DK0537320T3 (en) | 1995-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5391195A (en) | Device for carrying out an iontophoresis treatment on a patient | |
US4124030A (en) | Electro-therapeutic faradic current generator | |
JP2616757B2 (en) | Apparatus for treating living bone tissue with a vibrating electromagnetic field | |
US4431002A (en) | Modulated deep afferent stimulator | |
NZ531877A (en) | Apparatus and method for bioelectric stimulation, healing acceleration and pain relief | |
ATE179339T1 (en) | ELECTRICAL STIMULATION FOR THE TREATMENT OF INCONTINENCE AND OTHER NEUROMUSCULAR DISEASES | |
CA2010988A1 (en) | Method of generating electric pulse for biologic objects stimulation and apparatus thereof | |
KR920703147A (en) | Method and apparatus for delivering ion penetrating medicine in pulse state | |
EP0432240A1 (en) | Electrical apparatus for medical treatment | |
IE912227A1 (en) | Method and device for the treatment of epilepsy | |
US6512955B1 (en) | Electrical apparatus for therapeutic treatment | |
US4442839A (en) | Method of modulating energy in train of electrical pulses | |
US3295528A (en) | Electrical therapeutic equipment | |
JP2003135607A (en) | Low frequency medical treating system | |
JP2002515312A (en) | Magnetic stimulator | |
FR2369850A1 (en) | Medical appts. for ionising body tissues - uses electrical generator to provide square pulses to create potential difference in body cells | |
EP0269306A1 (en) | Low-frequency treatment device directed to use in a bath | |
JPS61500594A (en) | Non-invasive treatment method and circuit for implementing this method | |
WO1999006106A1 (en) | Apparatus for electrical stimulation of a body | |
RU2011386C1 (en) | Electrostimulator | |
JP2004113485A (en) | Biostimulus device | |
EP0625361A2 (en) | Very low frequency and very short duration sequential variable magnetic field generating system | |
RU2042364C1 (en) | Device for applying wave reflexotherapy | |
RU2005507C1 (en) | Device for electric analgesia | |
RU1813002C (en) | Apparatus for electrotherapeutic treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): CA JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1992909753 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1992909753 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
WWG | Wipo information: grant in national office |
Ref document number: 1992909753 Country of ref document: EP |