WO1991018653A3 - Cell assay device - Google Patents

Cell assay device Download PDF

Info

Publication number
WO1991018653A3
WO1991018653A3 PCT/US1991/003729 US9103729W WO9118653A3 WO 1991018653 A3 WO1991018653 A3 WO 1991018653A3 US 9103729 W US9103729 W US 9103729W WO 9118653 A3 WO9118653 A3 WO 9118653A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
porous
chamber
assay device
cell assay
Prior art date
Application number
PCT/US1991/003729
Other languages
French (fr)
Other versions
WO1991018653A2 (en
Inventor
Gillian M K Humphries
Donald Lee Miller
Jeffrey M Libby
Henry Lee Schwartz
John Wallace Parce
Henry Garrett Wada
Gregory L Kirk
Original Assignee
Molecular Devices Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Devices Corp filed Critical Molecular Devices Corp
Priority to EP91911165A priority Critical patent/EP0620845A1/en
Publication of WO1991018653A2 publication Critical patent/WO1991018653A2/en
Publication of WO1991018653A3 publication Critical patent/WO1991018653A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

Abstract

This invention encompasses porous microchambers which contain cells and permit liquid to flow in and out of the chamber while retaining cells within the chamber. These porous microchambers serve as disposable devices for placing cells in a micro flow chamber so that properties of the cells within the porous microchamber can be measured.
PCT/US1991/003729 1990-06-04 1991-06-04 Cell assay device WO1991018653A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP91911165A EP0620845A1 (en) 1990-06-04 1991-06-04 Cell assay device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/532,571 US5104804A (en) 1990-06-04 1990-06-04 Cell assay device used in a microphysiometer
US532,571 1990-06-04

Publications (2)

Publication Number Publication Date
WO1991018653A2 WO1991018653A2 (en) 1991-12-12
WO1991018653A3 true WO1991018653A3 (en) 1994-08-18

Family

ID=24122325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/003729 WO1991018653A2 (en) 1990-06-04 1991-06-04 Cell assay device

Country Status (5)

Country Link
US (2) US5104804A (en)
EP (1) EP0620845A1 (en)
JP (1) JPH05508991A (en)
CA (1) CA2083393A1 (en)
WO (1) WO1991018653A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9103794B2 (en) 2001-08-27 2015-08-11 Platypus Technologies Llc Substrates, devices, and methods for quantitative liquid crystal assays

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104804A (en) * 1990-06-04 1992-04-14 Molecular Devices Corporation Cell assay device used in a microphysiometer
US5460964A (en) * 1992-04-03 1995-10-24 Regents Of The University Of Minnesota Method for culturing hematopoietic cells
US5436151A (en) * 1992-04-03 1995-07-25 Regents Of The University Of Minnesota Method for culturing human hematopoietic stem cells in vitro
GB9311242D0 (en) * 1993-06-01 1993-07-21 Celsis Ltd Detection apparatus
SE9301929D0 (en) * 1993-06-07 1993-06-07 Kabi Pharmacia Ab PROCEDURE FOR COLLECTION OF PARTICLES
US5468605A (en) * 1993-10-15 1995-11-21 Molecular Devices Corp. Transverse flow plungers for microphysiometers
JPH11510051A (en) * 1995-07-28 1999-09-07 ミネソタ マイニング アンド マニュファクチャリング カンパニー Multi-zone sterilization indicator
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
NZ333346A (en) 1996-06-28 2000-03-27 Caliper Techn Corp High-throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
DK172855B1 (en) * 1996-11-12 1999-08-16 Unisense Aps Method for measuring the concentration of a medium in an environment, microsensor for use in the method and use
DE19721477A1 (en) * 1997-05-23 1998-11-26 Abb Patent Gmbh Microbial membrane reactor for use in flow systems
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US6982431B2 (en) * 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
WO1999041604A1 (en) * 1998-02-13 1999-08-19 Emory University Detection of neurodegenerative diseases, in vitro screening assays
US6197576B1 (en) * 1998-05-22 2001-03-06 Gideon Eden Instrument for detection of microorganisms
US6387605B1 (en) 1999-01-28 2002-05-14 Eastman Kodak Company Co-developers for black-and-white photothermographic elements
DE10003673C2 (en) * 2000-01-28 2003-04-10 Univ Halle Wittenberg Method for determining ion concentrations in the basolateral region of adherent cells and device for determining the ion concentration
US20040038227A1 (en) * 2000-05-08 2004-02-26 Philippe Verwaerde Method and technology for high-throughput lead profiling
US7118909B2 (en) * 2001-05-30 2006-10-10 Gevaert Matthew R Apparatus and method for biomaterial assay
AU2002365121A1 (en) * 2001-08-06 2003-07-09 Vanderbilt University System and methods for measuring at least one metabolic rate of a plurality of cells
US9249382B2 (en) * 2001-09-26 2016-02-02 Northeastern University Devices and methods for the selective isolation of microorganisms
JP4355212B2 (en) * 2001-12-21 2009-10-28 オーガノジェネシス インコーポレーテッド Variable volume chamber for cell culture and organ support
US20030157586A1 (en) * 2002-02-21 2003-08-21 Martin Bonde Device and method for conducting cellular assays using multiple fluid flow
AU2003265228A1 (en) * 2002-03-12 2003-12-22 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
US8268614B2 (en) 2002-05-22 2012-09-18 Platypus Technologies, Llc Method for assaying cell movement
US20040107986A1 (en) * 2002-12-06 2004-06-10 Neilson Andy C. High throughput microcalorimeter systems and methods
WO2004065618A2 (en) * 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
US20050064395A1 (en) 2003-07-25 2005-03-24 Platypus Technologies, Llc Liquid crystal based analyte detection
US7276351B2 (en) * 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US20070087401A1 (en) * 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
US8658349B2 (en) * 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
US20050131463A1 (en) * 2003-12-12 2005-06-16 Fedorov Nikolai B. Perfusion chamber for recording evoked and spontaneous electrical activity from submerged acute brain slices
US7666285B1 (en) 2004-02-06 2010-02-23 University Of Central Florida Research Foundation, Inc. Portable water quality monitoring system
US7662572B2 (en) 2005-08-25 2010-02-16 Platypus Technologies, Llc. Compositions and liquid crystals
JP4816111B2 (en) * 2006-01-31 2011-11-16 パナソニック株式会社 Micropipette and cell measurement system using the same
US7842499B2 (en) 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
US20080076170A1 (en) * 2006-09-27 2008-03-27 Tuija Annala Cell culture insert and cell culture vessel
DE102007016629A1 (en) * 2007-04-05 2008-10-09 Micronas Gmbh Sensor for detecting a toxic or hazardous gas mixture and operating method
US9968935B2 (en) 2007-08-20 2018-05-15 Platypus Technologies, Llc Devices for cell assays
WO2010031047A2 (en) 2008-09-15 2010-03-18 Platypus Technologies, Llc Detection of vapor phase compounds by changes in physical properties of a liquid crystal
US8202702B2 (en) * 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
EP2548943B1 (en) 2011-07-21 2016-05-11 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Clamping insert for cell culture
US9494577B2 (en) 2012-11-13 2016-11-15 Seahorse Biosciences Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
WO2014133051A1 (en) * 2013-02-27 2014-09-04 一般財団法人グローバルヘルスケア財団 Mask material for dividing cells into multiple populations
CN103499622B (en) * 2013-09-03 2015-04-15 西安建筑科技大学 Separate N2O selective microelectrode and preparation method thereof
CN106999926A (en) 2014-06-02 2017-08-01 安捷伦科技有限公司 Single-row microplate system and carrier for analyzing biological specimen
US10883978B2 (en) * 2017-01-31 2021-01-05 Agilent Technologies, Inc. Method and device for calibration of biological flux
JP6839599B2 (en) * 2017-04-24 2021-03-10 株式会社イントロテック Observation device
US10647954B1 (en) 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
US11566217B2 (en) 2019-08-13 2023-01-31 Flaskworks, Llc Duty cycle for cell culture systems
BR112022007637A2 (en) 2019-10-21 2022-07-12 Flaskworks Llc CELL CULTURE SYSTEMS AND METHODS
US20210139833A1 (en) * 2019-11-07 2021-05-13 Rutgers, The State University Of New Jersey Multilayer stackable tissue culture platform for 3d co-culture

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045291A (en) * 1976-07-15 1977-08-30 Berger Jacob E Tissue specimen container
US4614716A (en) * 1984-12-14 1986-09-30 Rohrback Technology Corporation Filter cell for electrochemically measuring enzyme concentrations
EP0221663A1 (en) * 1985-09-25 1987-05-13 Paul De La Pena Limited Methods and equipment for the bioelectrochemical cell measurement of microbial activity
EP0239697A2 (en) * 1986-03-20 1987-10-07 Costar Corporation Apparatus for growing tissue cultures in vitro
EP0242225A2 (en) * 1986-04-16 1987-10-21 Water Research Centre Pollutant detector
GB2220066A (en) * 1988-06-23 1989-12-28 Agricultural & Food Res Detecting biological contamination
DE3923279A1 (en) * 1989-07-14 1990-01-18 Will W Prof Dr Minuth MINUSHEETS IS A NEW PRODUCT FOR CULTIVATING CELLS IN ANY CONTAINERS IN A HIGHLY DIFFERENTIATED FORM ON THE MOST NATURAL DOCUMENT
US4908236A (en) * 1986-12-04 1990-03-13 Millipore Corporation Transparent porous membrane having hydrophilic surface and process

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3616409A (en) * 1968-06-07 1971-10-26 Univ Duke Electrode system for measuring ion activities in stream or sample
US3591480A (en) * 1968-07-15 1971-07-06 Ibm Glucose measuring system
US3725237A (en) * 1970-10-26 1973-04-03 Beckman Instruments Inc Apparatus for measuring ion activity of solutions
US3737379A (en) * 1971-04-28 1973-06-05 Univ Duke Instantaneous measurement of potassium and other specific ion activities
JPS5296791A (en) * 1976-02-09 1977-08-13 Japan Atom Energy Res Inst Preparation of composition including enzymes or microorganisms
DD131414A1 (en) * 1977-06-09 1978-06-21 Frieder Scheller STERILIZABLE ENZYME ELECTRODE
SU734280A1 (en) * 1977-09-29 1980-05-15 За витель Flow chamber for culturing
US4172770A (en) * 1978-03-27 1979-10-30 Technicon Instruments Corporation Flow-through electrochemical system analytical method
US4216065A (en) * 1979-06-18 1980-08-05 University Of Delaware Bio-selective electrode probes using tissue slices
FR2484077B1 (en) * 1980-06-06 1984-07-06 Inst Nat Sante Rech Med METHOD AND DEVICE FOR MEASURING THE DEFORMABILITY OF LIVING CELLS, ESPECIALLY RED BLOOD CELLS
US4734372A (en) * 1983-02-04 1988-03-29 Brown University Research Foundation Cell culturing methods and apparatus
JPS60244853A (en) * 1984-05-21 1985-12-04 Matsushita Electric Works Ltd Biosensor
JPS612060A (en) * 1984-06-15 1986-01-08 Matsushita Electric Works Ltd Biosensor
US4722898A (en) * 1985-04-29 1988-02-02 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
US4686190A (en) * 1986-02-19 1987-08-11 The Research Foundation Of State University Of New York Device useful for growing and/or testing biological materials
EP0242326A3 (en) * 1986-04-15 1990-04-18 Pharmatronic AG Device for studying the diffusion of a substance and method for the operation of the device
CA1283447C (en) * 1986-06-20 1991-04-23 John W. Parce Zero volume electrochemical cell
US4950379A (en) * 1987-04-09 1990-08-21 Nova Biomedical Corporation Polarographic cell
JPH051280Y2 (en) * 1987-10-12 1993-01-13
JPH0672858B2 (en) * 1988-04-18 1994-09-14 富士電機株式会社 Biosensor
US5278048A (en) * 1988-10-21 1994-01-11 Molecular Devices Corporation Methods for detecting the effect of cell affecting agents on living cells
US5104804A (en) * 1990-06-04 1992-04-14 Molecular Devices Corporation Cell assay device used in a microphysiometer

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045291A (en) * 1976-07-15 1977-08-30 Berger Jacob E Tissue specimen container
US4614716A (en) * 1984-12-14 1986-09-30 Rohrback Technology Corporation Filter cell for electrochemically measuring enzyme concentrations
EP0221663A1 (en) * 1985-09-25 1987-05-13 Paul De La Pena Limited Methods and equipment for the bioelectrochemical cell measurement of microbial activity
EP0239697A2 (en) * 1986-03-20 1987-10-07 Costar Corporation Apparatus for growing tissue cultures in vitro
EP0242225A2 (en) * 1986-04-16 1987-10-21 Water Research Centre Pollutant detector
US4908236A (en) * 1986-12-04 1990-03-13 Millipore Corporation Transparent porous membrane having hydrophilic surface and process
GB2220066A (en) * 1988-06-23 1989-12-28 Agricultural & Food Res Detecting biological contamination
DE3923279A1 (en) * 1989-07-14 1990-01-18 Will W Prof Dr Minuth MINUSHEETS IS A NEW PRODUCT FOR CULTIVATING CELLS IN ANY CONTAINERS IN A HIGHLY DIFFERENTIATED FORM ON THE MOST NATURAL DOCUMENT

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9103794B2 (en) 2001-08-27 2015-08-11 Platypus Technologies Llc Substrates, devices, and methods for quantitative liquid crystal assays

Also Published As

Publication number Publication date
EP0620845A1 (en) 1994-10-26
CA2083393A1 (en) 1991-12-05
JPH05508991A (en) 1993-12-16
US5104804A (en) 1992-04-14
WO1991018653A2 (en) 1991-12-12
US5536662A (en) 1996-07-16

Similar Documents

Publication Publication Date Title
WO1991018653A3 (en) Cell assay device
CA2106918A1 (en) Cell Culture Insert
WO2002013966A3 (en) Strip holder for use in a test strip meter
HK1024743A1 (en) Analytical device for membrane-based assays
NO164252C (en) CELL CULTIVATION MEDIUM AND USE THEREOF IN DETERMINING THE NUTRITIONAL AND BIOCHEMICAL CONDITIONS OF Lymphocytes.
WO2002026939A3 (en) Microfabrication of membranes for the growth of cells
CA2278630A1 (en) Filtration assembly
JPS55108284A (en) Bilogical container
ATE338521T1 (en) DISC PROSTHESIS WITH LIQUID-FILLED CHAMBER
AU7265787A (en) Liquid/liquid extractions with microporous membranes
ATE52026T1 (en) CONTROLLED RELEASE DEVICE.
EP0194407A3 (en) Measuring cap
AU9582398A (en) Methods and devices for the long-term culture of hematopoietic progenitor cells
ATE275190T1 (en) DEVICE FOR PERFORMING EXAMINATIONS ON CELL CULTURES
AU5122390A (en) Method and solid material body of the purification of fluids such as water, aqueous fluids and liquid fuels
ZA853212B (en) Device for withdrawing and conditioning samples of materials in solid,liquid or gaseous form,for the purpose of analysis thereof
DE3779905D1 (en) Cell culture carrier.
AU7354987A (en) Biological fluid measuring device
EP0277009A3 (en) Swab
ES8107388A1 (en) Sensor for measuring leakage.
AU3026789A (en) Device for delivering a fluid sample to a diagnostic device at a controlled rate
WO2001088182A3 (en) Lipid bilayer array methods and devices
EP0291338A3 (en) Electro-rheological fluid materials
USD277788S (en) Container for liquid for chemical analysis or similar article
USD288605S (en) Tray for supporting liquid sample tubes for medical test purposes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

COP Corrected version of pamphlet

Free format text: PAGES 1/8-8/8,DRAWINGS,REPLACED BY NEW PAGES 1/7-7/7;DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

WWE Wipo information: entry into national phase

Ref document number: 2083393

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 1991911165

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 1991911165

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1991911165

Country of ref document: EP