WO1989001783A3 - Recombinant antibody and method - Google Patents

Recombinant antibody and method Download PDF

Info

Publication number
WO1989001783A3
WO1989001783A3 PCT/GB1988/000731 GB8800731W WO8901783A3 WO 1989001783 A3 WO1989001783 A3 WO 1989001783A3 GB 8800731 W GB8800731 W GB 8800731W WO 8901783 A3 WO8901783 A3 WO 8901783A3
Authority
WO
WIPO (PCT)
Prior art keywords
derived
ham
recombinant antibody
antigen
immunoglobulin
Prior art date
Application number
PCT/GB1988/000731
Other languages
French (fr)
Other versions
WO1989001783A2 (en
Inventor
Mark William Bodmer
John Robert Adair
Nigel Richard Whittle
Original Assignee
Celltech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech Ltd filed Critical Celltech Ltd
Publication of WO1989001783A2 publication Critical patent/WO1989001783A2/en
Publication of WO1989001783A3 publication Critical patent/WO1989001783A3/en
Priority to FI892137A priority Critical patent/FI892137A/en
Priority to DK216089A priority patent/DK216089A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology

Abstract

The present invention provides a humanised antibody molecule (HAM) having specificity for the TAG-72 antigen and having an antigen binding site wherein at least the complementarity determining regions (CDRs) of the variable domain are derived from the mouse monoclonal antibody B72.3 (B72.3 MAb) and the remaining immunoglobulin-derived parts of the HAM are derived from a human immunoglobulin and a process for its production.
PCT/GB1988/000731 1987-09-04 1988-09-05 Recombinant antibody and method WO1989001783A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI892137A FI892137A (en) 1987-09-04 1989-05-03 RECOMBINANT ANTROPOSE SAMT FOERFARANDE.
DK216089A DK216089A (en) 1987-09-04 1989-05-03 RECOMBINANT ANTIBODY AND PROCEDURE FOR ITS MANUFACTURING

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878720833A GB8720833D0 (en) 1987-09-04 1987-09-04 Recombinant dna product
GB8720833 1987-09-04

Publications (2)

Publication Number Publication Date
WO1989001783A2 WO1989001783A2 (en) 1989-03-09
WO1989001783A3 true WO1989001783A3 (en) 1989-04-20

Family

ID=10623277

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/GB1988/000731 WO1989001783A2 (en) 1987-09-04 1988-09-05 Recombinant antibody and method
PCT/GB1988/000729 WO1989001782A1 (en) 1987-09-04 1988-09-05 Recombinant antibody
PCT/GB1988/000730 WO1989001974A1 (en) 1987-09-04 1988-09-05 Recombinant antibody

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/GB1988/000729 WO1989001782A1 (en) 1987-09-04 1988-09-05 Recombinant antibody
PCT/GB1988/000730 WO1989001974A1 (en) 1987-09-04 1988-09-05 Recombinant antibody

Country Status (11)

Country Link
US (1) US5219996A (en)
EP (3) EP0348442B1 (en)
JP (3) JP2761012B2 (en)
AT (2) ATE102254T1 (en)
AU (3) AU617367B2 (en)
CA (2) CA1337640C (en)
DE (2) DE3888172T2 (en)
DK (3) DK172630B1 (en)
FI (3) FI892135A0 (en)
GB (1) GB8720833D0 (en)
WO (3) WO1989001783A2 (en)

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* Cited by examiner, † Cited by third party
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