WO1984002578A1 - Assay technique - Google Patents

Assay technique Download PDF

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Publication number
WO1984002578A1
WO1984002578A1 PCT/GB1983/000340 GB8300340W WO8402578A1 WO 1984002578 A1 WO1984002578 A1 WO 1984002578A1 GB 8300340 W GB8300340 W GB 8300340W WO 8402578 A1 WO8402578 A1 WO 8402578A1
Authority
WO
WIPO (PCT)
Prior art keywords
formed surface
optical properties
species
technique
assayed
Prior art date
Application number
PCT/GB1983/000340
Other languages
French (fr)
Inventor
Robert Martin Pettigrew
Derek Geoffrey Layton
Alan Martin Smith
John Horace Fisher
Satham Petty-Saphon
Original Assignee
Comtech Res Unit
Robert Martin Pettigrew
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838301021A external-priority patent/GB8301021D0/en
Application filed by Comtech Res Unit, Robert Martin Pettigrew filed Critical Comtech Res Unit
Priority to JP59500405A priority Critical patent/JPH0627742B2/en
Publication of WO1984002578A1 publication Critical patent/WO1984002578A1/en
Priority to NO843322A priority patent/NO164444C/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

Abstract

An assay technique for the qualitative and/or quantitative detection of a chemical, biochemical or biological detection of a chemical, biochemical or biological species in a sample. The technique comprises (a) coating at least a predetermined part of a pre-formed surface on a substrate with a thin film of a material capable of binding the species to be assayed, the pre-formed surface being optically active with respect to radiation at least over a predetermined band of wavelengths; (b) contacting the coated surface with the sample; and (c) observing the optical properties of said pre-formed surface in order to determine a qualitative and/or quantitative change in optical properties as a result of the binding of the species onto said thin film of material. The optical properties of the pre-formed surface may be observed before and after step (b) in order to determine any change in optical properties, or they may be monitored during step (b). The pre-formed surface is preferably a grating. An article for use in the above technique is also disclosed, and comprises a substrate carrying said pre-formed surface which in turn is coated with the receptive material for the species to be assayed.
PCT/GB1983/000340 1982-12-21 1983-12-21 Assay technique WO1984002578A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP59500405A JPH0627742B2 (en) 1982-12-21 1983-12-21 Assay method and apparatus therefor
NO843322A NO164444C (en) 1982-12-21 1984-08-20 DEVICE FOR USE IN QUALITATIVE AND / OR QUANTITATIVE DETERMINATION OF A CHEMICAL, BIOCHEMICAL OR BIOLOGICAL COMPONENT IN A SAMPLE.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8236333 1982-12-21
GB838301021A GB8301021D0 (en) 1982-12-21 1983-01-14 Assay technique

Publications (1)

Publication Number Publication Date
WO1984002578A1 true WO1984002578A1 (en) 1984-07-05

Family

ID=26284746

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1983/000340 WO1984002578A1 (en) 1982-12-21 1983-12-21 Assay technique

Country Status (7)

Country Link
US (2) US4931384A (en)
EP (1) EP0112721B1 (en)
JP (2) JPH0627742B2 (en)
AU (1) AU570425B2 (en)
CA (1) CA1237645A (en)
DE (1) DE3376685D1 (en)
WO (1) WO1984002578A1 (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0228359A2 (en) * 1986-01-02 1987-07-08 Laboratoires Sanders-Probel, S.A. Method of detecting reactive agents and means for performing such
US4767719A (en) * 1986-05-20 1988-08-30 Amersham International Plc Assay apparatus having piezoelectric slab generating effective diffraction grating in applied analyte-specific film
WO1988007202A1 (en) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Improved assay technique and apparatus therefor
WO1988007203A1 (en) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Polymer-coated optical structures
WO1988010418A1 (en) * 1987-06-20 1988-12-29 Ares-Serono Research & Development Limited Partner Waveguide sensor
WO1990009576A1 (en) * 1989-02-08 1990-08-23 Plessey Overseas Limited A method for detecting optical phase changes during biosensor operation, biosensing apparatus and a biosensor adapted for use in the same
WO1991013339A1 (en) * 1990-03-02 1991-09-05 Fisons Plc Sample cell for use in chemical or biochemical assays
WO1994000763A1 (en) * 1992-06-24 1994-01-06 Akzo Nobel N.V. Method for determining multiple immunocomplexes on one surface using spectroscopy
US5422283A (en) * 1990-02-22 1995-06-06 The Royal Institution For The Advancement Of Learning Solid-phase interferometric immunoassay system
US5468620A (en) * 1991-03-09 1995-11-21 Fisons Plc Methods and device for glycosylation analysis
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7497992B2 (en) 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US9778267B2 (en) 2007-07-11 2017-10-03 X-Body, Inc. Methods for identifying modulators of ion channels
US10359573B2 (en) 1999-11-05 2019-07-23 Board Of Regents, The University Of Texas System Resonant waveguide-granting devices and methods for using same

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4621063A (en) * 1982-10-12 1986-11-04 The Center For Immunological Studies Methods for the detection and quantitation of immunological substances
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
FR2570189B1 (en) * 1984-09-13 1986-09-26 Immunotech Sa IMMUNOENZYMOLOGICAL ASSAY PROCESS AND MEANS FOR IMPLEMENTING IT
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment
DE3585780D1 (en) * 1984-12-24 1992-05-07 Abbott Lab ANALYTICAL DEVICE AND METHOD FOR USE THEREOF.
US6060237A (en) 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
EP0239569A4 (en) * 1985-09-20 1989-10-04 Hsg Venture Neurological and biological molecular electro-optical devices and method.
US5468606A (en) * 1989-09-18 1995-11-21 Biostar, Inc. Devices for detection of an analyte based upon light interference
EP0251707A1 (en) * 1986-06-26 1988-01-07 Ortho Diagnostic Systems Inc. Methods for calibration of extended surface in homogeneous rate immunoassays
GB8618133D0 (en) * 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
IL85137A (en) * 1987-01-21 1992-02-16 Ares Serono Res & Dev Ltd Method of assaying for a ligand using surface plasmon resonance effect
CA1305921C (en) * 1987-01-30 1992-08-04 Eric K. Gustafson Diffraction immunoassay and reagents
GB2202045B (en) * 1987-03-10 1991-08-21 Pa Consulting Services Improvements relating to sensors for performing assays
GB8801807D0 (en) * 1988-01-27 1988-02-24 Amersham Int Plc Biological sensors
EP0341928A1 (en) * 1988-05-10 1989-11-15 AMERSHAM INTERNATIONAL plc Improvements relating to surface plasmon resonance sensors
US5089387A (en) * 1988-07-07 1992-02-18 Adeza Biomedical Corporation Dna probe diffraction assay and reagents
SE8804074D0 (en) * 1988-11-10 1988-11-10 Pharmacia Ab SENSOR UNIT AND ITS USE IN BIOSENSOR SYSTEM
SE462454B (en) * 1988-11-10 1990-06-25 Pharmacia Ab METHOD FOR USE IN BIOSENSORS
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6919211B1 (en) * 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US6955915B2 (en) * 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
AU6513790A (en) * 1989-09-18 1991-04-18 Biostar Medical Products, Inc. Apparatus for detection of an immobilized analyte
US5541057A (en) * 1989-09-18 1996-07-30 Biostar, Inc. Methods for detection of an analyte
EP0493484B1 (en) * 1989-09-18 1997-02-26 Biostar Medical Products Incorporated Method and apparatus for detection of an analyte
US5032730A (en) * 1989-10-02 1991-07-16 Fuji Photo Film Co., Ltd. Immunoassay apparatus
EP0455067B1 (en) * 1990-05-03 2003-02-26 F. Hoffmann-La Roche Ag Micro-optical sensor
IE911670A1 (en) * 1990-05-17 1991-11-20 Adeza Biomedical Corp Highly reflective biogratings and method
DE4124920C2 (en) * 1990-07-27 1993-12-23 Hitachi Ltd Biochemical analyzer with a prism cell for attenuated total reflection and a cooling device
DE4024476C1 (en) * 1990-08-02 1992-02-27 Boehringer Mannheim Gmbh, 6800 Mannheim, De
DK0834576T3 (en) * 1990-12-06 2002-04-22 Affymetrix Inc A Delaware Corp Detection of nucleic acid sequences
DE4039677A1 (en) * 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh UNIVERSAL BINDING FILM
US5763191A (en) * 1990-12-12 1998-06-09 Boehringer Mannheim Gmbh Universal binding film
US5470757A (en) * 1991-06-25 1995-11-28 Minnesota Mining And Manufacturing Company Spectroscopic sample holder and method for using same
DE59410197D1 (en) * 1993-03-26 2002-11-21 Hoffmann La Roche Optical method and device for analyzing substances on sensor surfaces
US5413939A (en) * 1993-06-29 1995-05-09 First Medical, Inc. Solid-phase binding assay system for interferometrically measuring analytes bound to an active receptor
DE4331596A1 (en) * 1993-09-17 1995-03-23 Boehringer Mannheim Gmbh Method for the quantitative analysis of sample liquids
GB9406142D0 (en) 1994-03-28 1994-05-18 British Tech Group A sensor
US7625697B2 (en) 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
FR2730812B1 (en) * 1995-02-17 1997-03-14 Thomson Csf BIOCHEMICAL SENSOR
AU7526496A (en) * 1995-10-25 1997-05-15 University Of Washington Surface plasmon resonance electrode as chemical sensor
US6355198B1 (en) 1996-03-15 2002-03-12 President And Fellows Of Harvard College Method of forming articles including waveguides via capillary micromolding and microtransfer molding
EP0894043B1 (en) * 1996-03-15 2001-10-31 President And Fellows Of Harvard College Method of forming articles and patterning surfaces via capillary micromolding
US5912456A (en) * 1996-03-19 1999-06-15 Texas Instruments Incorporated Integrally formed surface plasmon resonance sensor
US7153651B1 (en) * 1996-10-31 2006-12-26 Inverness Medical - Biostar, Inc. Flow-through optical assay devices providing laminar flow of fluid samples, and methods of construction thereof
US5846843A (en) * 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
US5958704A (en) 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
US6333093B1 (en) 1997-03-17 2001-12-25 Westaim Biomedical Corp. Anti-microbial coatings having indicator properties and wound dressings
US5955378A (en) * 1997-08-20 1999-09-21 Challener; William A. Near normal incidence optical assaying method and system having wavelength and angle sensitivity
US5925878A (en) * 1997-08-20 1999-07-20 Imation Corp. Diffraction anomaly sensor having grating coated with protective dielectric layer
US5994150A (en) * 1997-11-19 1999-11-30 Imation Corp. Optical assaying method and system having rotatable sensor disk with multiple sensing regions
JP3437170B2 (en) * 1997-12-12 2003-08-18 ピーイー コーポレイション （エヌワイ） Optical resonance analysis system
US6251615B1 (en) 1998-02-20 2001-06-26 Cell Analytics, Inc. Cell analysis methods
US5986762A (en) * 1998-06-15 1999-11-16 Imation Corp. Optical sensor having optimized surface profile
US6320991B1 (en) 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
ES2251244T3 (en) * 1998-11-20 2006-04-16 Graffinity Pharmaceutical Design Gmbh MEASUREMENT DEVICE AND MEASUREMENT METHOD FOR PARALLEL READING OF SPR SENSORS.
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
EP1192448B1 (en) * 1999-07-05 2006-09-27 Novartis AG Process of using a sensor platform
GB9916569D0 (en) * 1999-07-14 1999-09-15 Unilever Plc Apparatus and method for sensing metal ions
WO2001014823A1 (en) * 1999-08-19 2001-03-01 The Regents Of The University Of California Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US7198939B2 (en) * 2000-01-28 2007-04-03 Agilent Technologies, Inc. Apparatus for interrogating an addressable array
DE10008006C2 (en) 2000-02-22 2003-10-16 Graffinity Pharm Design Gmbh SPR sensor and SPR sensor arrangement
AU2001242173A1 (en) * 2000-03-22 2001-10-03 Jane B. Goh Method and apparatus for assay for multiple analytes
US7198747B2 (en) 2000-09-18 2007-04-03 President And Fellows Of Harvard College Fabrication of ceramic microstructures
US7070987B2 (en) 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7202076B2 (en) 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7217574B2 (en) 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7875434B2 (en) 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7371562B2 (en) * 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7101660B2 (en) 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US6576430B1 (en) * 2000-11-20 2003-06-10 Becton, Dickinson And Company Detection of ligands by refractive surface methods
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6710877B2 (en) * 2001-07-23 2004-03-23 Corning Incorporated Apparatus and methods for determining biomolecular interactions
EP1424549A1 (en) * 2001-08-07 2004-06-02 Mitsubishi Chemical Corporation SURFACE PLASMON RESONANCE SENSOR CHIP, AND SAMPLE ANALYSIS METHOD AND ANALYSIS APPARATUS USING THE SAME
EP1434994A2 (en) * 2001-09-13 2004-07-07 Axela Biosensors Inc. Method and apparatus for assay based on light diffraction
FI118061B (en) * 2001-09-24 2007-06-15 Beanor Oy Procedure and bio donor for analysis
US7300798B2 (en) * 2001-10-18 2007-11-27 Agilent Technologies, Inc. Chemical arrays
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US7098041B2 (en) 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
FI115166B (en) * 2001-12-31 2005-03-15 Biofons Oy Diagnostic procedures
US20030154149A1 (en) * 2002-02-13 2003-08-14 Dilip Gajendragadkar System and method of creating and executing a restricted stock sale plan
US7807348B2 (en) * 2002-03-20 2010-10-05 Wisconsin Alumni Research Foundation Optical imaging of nanostructured substrates
US6791690B2 (en) * 2002-04-30 2004-09-14 Agilent Technologies, Inc. Reading dry chemical arrays
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
EP1535241A1 (en) * 2002-08-20 2005-06-01 Cyvera Corporation Diffraction grating-based optical identification element
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7923260B2 (en) * 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
WO2004019277A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7126755B2 (en) * 2002-09-12 2006-10-24 Moon John A Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
CA2498913A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Assay stick comprising coded microbeads
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
CA2498933C (en) 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
WO2004025561A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
EP1540591A1 (en) * 2002-09-12 2005-06-15 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7070406B2 (en) * 2003-04-29 2006-07-04 Hewlett-Packard Development Company, L.P. Apparatus for embossing a flexible substrate with a pattern carried by an optically transparent compliant media
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
US20050214803A1 (en) * 2003-11-06 2005-09-29 Sru Biosystems, Llc High-density amine-functionalized surface
US7555144B2 (en) * 2003-12-03 2009-06-30 Centre National De La Recherche Scientifique (Cnrs) Optical scanning device for liquid biological samples, process of operation and computer program for a computer connected to said device
CA2834041C (en) 2003-12-31 2017-05-16 President And Fellows Of Harvard College Assay device and method
EP1566627A1 (en) * 2004-02-18 2005-08-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Surface plasmon field-enhanced diffraction sensor
US20060194346A1 (en) * 2004-02-18 2006-08-31 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Surface plasmon-field-enhanced diffraction sensor
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US20070292964A1 (en) * 2004-09-10 2007-12-20 Matsushita Electric Industrial Co., Ltd. Measuring Equipment and Measuring Method
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
EP2194485B1 (en) 2004-11-16 2012-10-17 Illumina, Inc. Method and apparatus for reading coded microbeads
WO2006055735A2 (en) 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
US20060134324A1 (en) * 2004-11-17 2006-06-22 Illumina, Inc. Filament with easily removed protective coating and methods for stripping the same
US8550985B2 (en) * 2004-12-14 2013-10-08 Boston Scientific Scimed, Inc. Applications of LIPSS in polymer medical devices
US7655421B2 (en) * 2005-06-17 2010-02-02 Ciencia, Inc. Cytometer on a chip
US20070141597A1 (en) * 2005-10-25 2007-06-21 Harmon H J Biomimetic Biodetector of Toxins, Viruses, Bacteria, and Biological Factors
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
KR20090086235A (en) * 2006-10-31 2009-08-11 에스알유 바이오시스템즈, 인코포레이티드 Method for blocking non-specific protein binding on a functionalized surface
JP5397577B2 (en) * 2007-03-05 2014-01-22 オムロン株式会社 Surface plasmon resonance sensor and chip for the sensor
AU2008242664B2 (en) * 2007-04-19 2011-10-20 Sru Biosystems, Inc. Method for employing a biosensor to detect small molecules that bind directly to immobilized targets
WO2009013707A2 (en) * 2007-07-26 2009-01-29 Koninklijke Philips Electronics N.V. A carrier for optical examinations with light reflections
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
EP2304500A1 (en) * 2008-06-04 2011-04-06 SRU Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
US7961313B2 (en) * 2008-08-11 2011-06-14 Ut-Battelle, Llc Photoacoustic point spectroscopy
US8194246B2 (en) * 2008-08-11 2012-06-05 UT-Battellle, LLC Photoacoustic microcantilevers
US8368897B2 (en) * 2008-08-22 2013-02-05 Ciencia, Inc. Versatile surface plasmon resonance analyzer with an integral surface plasmon resonance enhanced fluorescence mode
FR2935804B1 (en) * 2008-09-11 2012-11-02 Innopsys METHOD OF SEARCHING AT LEAST ONE ANALYTE IN A MEDIUM WHICH MAY CONTAIN IT
US20100273185A1 (en) * 2009-04-27 2010-10-28 Sru Biosystems, Inc. Detection of Biased Agonist Activation
CA2761114A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc. Detection of changes in cell populations and mixed cell populations
US8593630B2 (en) * 2009-10-07 2013-11-26 The Board Of Trustees Of The University Of Illinois Discrete frequency spectroscopy and instrumentation
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
CA2781556C (en) 2009-11-23 2015-05-19 Cyvek, Inc. Method and apparatus for performing assays
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
WO2013134745A1 (en) 2012-03-08 2013-09-12 Cyvek, Inc Portable microfluidic assay devices and methods of manufacture and use
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
JPWO2011111785A1 (en) * 2010-03-10 2013-06-27 国立大学法人東京工業大学 Layer structure for measuring reflected light intensity, apparatus comprising layer structure for measuring reflected light, and method for measuring film thickness and / or mass and / or viscosity of thin film
US20110231966A1 (en) * 2010-03-17 2011-09-22 Ali Passian Scanning probe microscopy with spectroscopic molecular recognition
US8448261B2 (en) 2010-03-17 2013-05-21 University Of Tennessee Research Foundation Mode synthesizing atomic force microscopy and mode-synthesizing sensing
EP2553151A4 (en) * 2010-03-26 2013-07-31 X Body Inc Use of induced pluripotent cells and other cells for screening compound libraries
CN106552682B (en) 2011-03-22 2020-06-19 西维克公司 Microfluidic device and methods of manufacture and use
US9325947B2 (en) * 2011-06-28 2016-04-26 Inview Technology Corporation High-speed event detection using a compressive-sensing hyperspectral-imaging architecture
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3979184A (en) * 1975-05-27 1976-09-07 General Electric Company Diagnostic device for visually detecting presence of biological particles
GB1564333A (en) * 1975-08-27 1980-04-10 Gen Electric Method for contrast in surface immunological tests
US4222743A (en) * 1978-07-20 1980-09-16 Wang Wei Kung Method and apparatus for detecting biological particles by fluorescent stain
EP0073980A1 (en) * 1981-09-05 1983-03-16 Lundström, Kurt Ingemar, Prof. Dr. Method and device for the determination of biological components
WO1983001112A1 (en) * 1981-09-18 1983-03-31 Carter, Timothy Method for the determination of species in solution with an optical wave-guide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054646A (en) * 1973-07-30 1977-10-18 General Electric Method and apparatus for detection of antibodies and antigens
US3853467A (en) * 1973-08-15 1974-12-10 Gen Electric Method and apparatus for immunological detection of biological particles
DE2440367C2 (en) * 1973-08-30 1984-03-15 General Electric Co., Schenectady, N.Y. Process for the production of multimolecular layers from immunologically complexed proteins on a substrate
US4011308A (en) * 1974-01-04 1977-03-08 General Electric Company Method for surface immunological detection of biological particles by the use of tagged antibodies
US3926564A (en) * 1974-02-25 1975-12-16 Gen Electric Substrate for immunological tests and method of fabrication thereof
US4041146A (en) * 1975-05-01 1977-08-09 General Electric Company Method for detection of biological particles
US4050895A (en) * 1975-09-26 1977-09-27 Monsanto Research Corporation Optical analytical device, waveguide and method
US4090849A (en) * 1976-12-20 1978-05-23 General Electric Company Diagnostic device and manufacture thereof
US4582885A (en) * 1978-07-20 1986-04-15 Minnesota Mining And Manufacturing Company Shaped plastic articles having replicated microstructure surfaces
US4474186A (en) * 1979-07-17 1984-10-02 Georgetown University Computerized electro-oculographic (CEOG) system with feedback control of stimuli
US4321057A (en) * 1979-09-20 1982-03-23 Buckles Richard G Method for quantitative analysis using optical fibers
DE3215484A1 (en) * 1982-04-26 1983-11-03 Sagax Instrument AB, 18302 Täby MULTIPLE LAYERS OF LAYER AND PROCESS FOR DETECTING AND / OR MEASURING THE CONCENTRATION OF A CHEMICAL SUBSTANCE, IN PARTICULAR BIOLOGICAL ORIGIN
US4537861A (en) * 1983-02-03 1985-08-27 Elings Virgil B Apparatus and method for homogeneous immunoassay
AU564398B2 (en) * 1983-02-24 1987-08-13 Abbott Laboratories Improved fluorometric assay
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
GB8423204D0 (en) * 1984-09-14 1984-10-17 Comtech Res Unit Assay technique and equipment

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3979184A (en) * 1975-05-27 1976-09-07 General Electric Company Diagnostic device for visually detecting presence of biological particles
GB1564333A (en) * 1975-08-27 1980-04-10 Gen Electric Method for contrast in surface immunological tests
US4222743A (en) * 1978-07-20 1980-09-16 Wang Wei Kung Method and apparatus for detecting biological particles by fluorescent stain
EP0073980A1 (en) * 1981-09-05 1983-03-16 Lundström, Kurt Ingemar, Prof. Dr. Method and device for the determination of biological components
WO1983001112A1 (en) * 1981-09-18 1983-03-31 Carter, Timothy Method for the determination of species in solution with an optical wave-guide

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0228359A3 (en) * 1986-01-02 1988-06-01 Laboratoires Sanders-Probel, S.A. Method of detecting reactive agents and means for performing such
EP0228359A2 (en) * 1986-01-02 1987-07-08 Laboratoires Sanders-Probel, S.A. Method of detecting reactive agents and means for performing such
US4767719A (en) * 1986-05-20 1988-08-30 Amersham International Plc Assay apparatus having piezoelectric slab generating effective diffraction grating in applied analyte-specific film
US5310686A (en) * 1987-03-10 1994-05-10 Ares Serono Research & Development Limited Partnership Polymer-coated optical structures
WO1988007202A1 (en) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Improved assay technique and apparatus therefor
WO1988007203A1 (en) * 1987-03-10 1988-09-22 Ares-Serono Research & Development Limited Partner Polymer-coated optical structures
WO1988010418A1 (en) * 1987-06-20 1988-12-29 Ares-Serono Research & Development Limited Partner Waveguide sensor
WO1990009576A1 (en) * 1989-02-08 1990-08-23 Plessey Overseas Limited A method for detecting optical phase changes during biosensor operation, biosensing apparatus and a biosensor adapted for use in the same
US5422283A (en) * 1990-02-22 1995-06-06 The Royal Institution For The Advancement Of Learning Solid-phase interferometric immunoassay system
WO1991013339A1 (en) * 1990-03-02 1991-09-05 Fisons Plc Sample cell for use in chemical or biochemical assays
US5468620A (en) * 1991-03-09 1995-11-21 Fisons Plc Methods and device for glycosylation analysis
WO1994000763A1 (en) * 1992-06-24 1994-01-06 Akzo Nobel N.V. Method for determining multiple immunocomplexes on one surface using spectroscopy
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US10359573B2 (en) 1999-11-05 2019-07-23 Board Of Regents, The University Of Texas System Resonant waveguide-granting devices and methods for using same
US7094595B2 (en) 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7118710B2 (en) 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7497992B2 (en) 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US9778267B2 (en) 2007-07-11 2017-10-03 X-Body, Inc. Methods for identifying modulators of ion channels
US11016100B2 (en) 2007-07-11 2021-05-25 X-Body, Inc. Methods for identifying modulators of ion channels

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DE3376685D1 (en) 1988-06-23
EP0112721B1 (en) 1988-05-18
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US5118608A (en) 1992-06-02
JPH0627742B2 (en) 1994-04-13
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AU2410684A (en) 1984-07-17
US4931384A (en) 1990-06-05
AU570425B2 (en) 1988-03-17

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