|Publication number||USRE37117 E1|
|Application number||US 08/888,495|
|Publication date||27 Mar 2001|
|Filing date||7 Jul 1997|
|Priority date||22 Sep 1992|
|Publication number||08888495, 888495, US RE37117 E1, US RE37117E1, US-E1-RE37117, USRE37117 E1, USRE37117E1|
|Inventors||Thomas J. Palermo|
|Original Assignee||Target Therapeutics, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (30), Referenced by (110), Classifications (18), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a continuation of application Ser. No. 08/539,781, filed Oct. 5, 1995, now abandoned.
This invention is a surgical instrument and specifically is a device for delivering embolic coils to a selected site within the vasculature of a human body via use of a catheter. In particular, the device uses embolic coils having interlocking clasps on the coils which are secured to each other by a control wire within the catheter. Retraction of the control wire into the catheter body uncouples the distal coil.
The endovascular treatment of a variety of vascular maladies throughout the body is an increasingly more important form of therapy. Catheters have been used to place various treatment materials, devices, and drugs within arteries and veins in the human body. Examples of these devices and their use in such treatments are shown in commonly assigned U.S. patent application Ser. Nos. 07/806,898 (“Detachable Pusher-Vasoocclusive Coil Assembly with Threaded Coupling”) and 07/806,912 (“Detachable Pusher-Vasoocclusive Coil Assembly with Interlocking Ball and Keyway Coupling”). These show methods and devices for delivery of coils or wires within the human body to sites such as aneurysms, to occlude those sites. Coils such as are discussed in those two documents (as well as in U.S. Pat. No. 4,994,069), may be of a regular or helical configuration or assume a random convoluted configuration at the site. The coils normally are made of a radiopaque, biocompatible metal such as platinum, gold, tungsten, or alloys of these and other metals.
In treating aneurysms it is common to place a number of coils within the aneruysm. The coils occlude the site by posing a physical barrier to blood flow and by promoting thrombus formation at the site.
Coils have typically been placed at the desired site within the vasculature using a catheter and a pusher. The site is first accessed by the catheter. In treating peripheral or neural conditions requiring occlusion, the sites are accessed with flexible, small diameter catheters such as those shown in U.S. Pat. Nos. 4,739,768 and 4,813,934. The catheter may be guided to the site through the use of guidewires (see U.S. Pat. No. 4,884,579) or by flow-directed means such as balloons placed at the distal end of the catheter. Use of guidewires involves the placement of relatively long, torqueable proximal wire sections within the catheter attached to more flexible distal end wire sections designed to be advanced across sharp bends at vessel junctions. The guidewire is visible using x-ray and allows a catheter to be placed in extremely tortuous vessels, even though surrounded by soft tissue such as the brain.
Once the site has been reached, the catheter lumen is cleared by removing the guidewire (if a guidewire has been used), and the coil is placed into the proximal open end of the catheter and advanced through the catheter with a pusher. Pushers are wires having a distal end that is adapted to engage and push the coil through the catheter lumen as the pusher is advanced through the catheter. When the coil reaches the distal end of the catheter, it is discharged from the catheter by the pusher into the vascular site. This technique of discharging the coil from the distal end of the catheter has a number of undesirable limitation. First, because of the plunging action of the pusher and the coil, the positioning of the coil at the site cannot be controlled to a fine degree of accuracy. Second, once the coil has left the catheter, it is difficult to reposition or retrieve the coil if such is desired.
Several techniques have been developed to enable more accurate placement of coils within a vessel. In one technique (U.S. Pat. No. 5,122,136, issued Jun. 16, 1992) the coil is bonded via a metal-to-metal joint to the distal end of the pusher. The pusher and coil are made of dissimilar metals. The coil-carrying pusher is advanced through the catheter to the site and a low electrical current is passed through the pusher-coil assembly. The current causes the joint between the pusher and the coil to be severed via electrolysis. The pusher may then be retracted leaving the detached coil at an exact position within the vessel. In addition to enabling more accurate coil placement, the electric current may facilitate thrombus formation at the coil site. The only perceived disadvantage of this method is that the electrolytic release of the coil requires a period of time so that rapid detachment of the coil from the pusher does not occur.
Another technique for detaching an embolic coil is shown in commonly assigned U.S. patent application Ser. No. 07/806,912. In that document, a coil having an enlarged portion is mated with a pusher having a keyway adapted to receive the enlarged portion of the coil in an interlocking relationship is covered by a coaxial member about the pusher and the coil. The coaxial member is movable by sliding the member axially. As the coaxial member is moved away from the junction where the coil's member engages the member of the keyway of the pusher, the coil disengages and the pusher is removed.
Another device for placement of coils is shown in commonly assigned U.S. patent application Ser. No. 07/806,898. This device includes a coil having a helical portion at one end and a pusher which is threaded to the inside of the helical coil by the use of a threaded section on the outside of the pusher. The device operates to release the coil by engaging the proximal end of the coil with a sleeve while the pusher is unthreaded. Once the pusher is free, the sleeve may be used to push the coil out into the treatment area.
Another method of placing an embolic coil is shown in U.S. Pat. No. 5,108,407. This patent shows the use of a device in which embolic coils are separated from the distal end of a catheter by the use of heat-releasable adhesive bonds. The coil adheres to the therapeutic device via a mounting connection using a heat sensitive adhesive. Laser energy is transferred through a fiber optic cable, which cable terminates at the connector. The connector becomes warm and releases the adhesive bond between the connection and the coil.
None of these disclosed devices suggest the use of an interlocking latch which allows an embolic coil to be precisely positioned and then released upon retraction of a control wire positioned within that latch.
This invention is a device for placing detachable coils within the vasculature of the human body so to occlude that site with the coils. The device includes a coil that carries an interlocking clasp at at least one end of the coil, preferably at its proximal end and a pusher (positioned within the catheter) which has a clasp at its distal end which interlocks with the clasp situated on the coil. The coils may have interlocking clasps at each end thereby allowing a number of coils to be strung together and yet individually released. A control wire passing through the catheter, the pusher assembly, the pusher clasp, and the coil clasp releases the coil as the control wire is retracted through axial passageways or openings provided in the two clasps.
Another portion of the invention is a method for occluding a selected vascular site comprising the steps of: (a) accessing the site with a distal end of a catheter; (b) advancing the assembly described above through the catheter with the coil clasp and the pusher clasp interlocked to a position out the end of the distal end of the catheter; (c) withdrawing the control wire from the two clasps to thereby detach the coil from the pusher; and (d) withdrawing the catheter and pusher from the vessel.
FIGS. 1A and 1B show, respectively, a partial sectional view of a pusher assembly and an engaged coil assembly having an interlocking clasp at only one end and a front three-quarters view of one variation of the interlocking clamp.
FIG. 2 shows a series of coil assemblies having either one or two interlocking clasps at their ends.
FIG. 3 shows deployment of the interlocking coil within a catheter;
FIGS. 4 and 5 show the operation of the assembly as it places a coil within a target site;
FIGS. 6A and 6B show, respectively, a partial sectional view of a pusher assembly and an engaged coil assembly having a variation of an interlocking clasp and a front three-quarter view of that variation of the interlocking clasp.
FIGS. 7A, 7B, and 7C show a method of attaching coils having the interlocking clasp shown in FIGS. 6A and 6B to a pusher body within the catheter lumen.
FIG. 8 shows a variation of the invention in which both the coils and the pusher body have simple loops as interlocking clasps.
The coil assembly (100) is shown in FIG. 1. The coil (102) is shown as helical in form, although it may be any other suitable form. The coil should be of a size sufficiently small that it may be advanced through a catheter that is appropriately sized for accessing the targeted vascular site. For instance, when accessing a brain aneurysm in a small vessel, an appropriately sized catheter is quite small and very flexible. The coil in such a situation must be small enough to fit through the catheter and out its distal end at the treatment site.
The coil is desirably made up of a radiopaque, physiologically compatible material. The material may be platinum, gold, tungsten, or alloys of these. Certain polymers are also suitable as coil material either alone or in conjunction with metallic markers providing radiopacity. These materials are chosen so that the procedure of locating coils within the vessel may be viewed using radiography. However, it is also contemplated that these coils may be made of various other biologically inert polymers or of carbon fiber.
The size of the coil and its constituent winding will depend upon the use to which the coil will be placed. For occluding peripheral or neural sites, the coils will typically be made of 0.05 to 0.15 mm diameter wire (platinum or platinum/tungsten alloy) that is wound to have an inner diameter of 0.15 to 1.5 mm with a minimum pitch—that is to say that the pitch is equal to the diameter of the wire used in the coil. The length of the coil will normally be in the range of 0.5 to 60 cm, preferably 0.5 to 40 cm.
If desired, the coil may be formed in such a way that the coil is essentially linear as it passes through the catheter and yet assumes a randomly oriented relaxed condition after it is released from the distal end of the catheter. A discussion of this variation may be found in U.S. Pat. No. 4,994,069.
Fixedly attached to coil (102), as is shown in FIG. 1A, is interlocking clasp (104). Interlocking clasp (104) as is depicted in the front three-quarter view in FIG. 1B, has an interior passageway allowing the control wire (106) to pass completely therethrough. As is shown in FIG. 1A, the male portion of the next adjacent interlocking clasp (110) fits into the area (108) left within clasp (104) so to allow the interlocking to take place. Said another way, the distal portion of interlocking clasp (104) is generally cylindrical in shape but has a surface (107), which may be cut or milled away, allowing the portion to mesh within the middle area (108) of an adjacent clasp. The proximal section is adapted for attaching to a coil or to a pusher assembly. The attachment may be by welding, soldering, gluing, or the like. With a control wire (106) passing through the axis of both interlocking clasps (104) and (110), the two are locked together. As is shown in FIG. 1A, the control wire may extend through the length of coil (102).
FIG. 2 shows an intermediate coil assembly (110) comprising coil (102) and interlocking clasp (104) (joined with coil assembly (112) which has interlocking clasp (114) fixedly attached at both ends of the intervening coil (116). As was the situation in FIG. 1A, the proximal interlocking clasp (114) is joined by control wire (106) with interlocking clasp (110). In this way, a significant number of coils (112) may be loaded onto a control wire (106) and delivered to the treatment site without removal of the control wire from the catheter.
FIG. 3 shows the relationship of coil assembly (100) and the pusher assembly (118) with it distal interlocking clasp (110) as it fits within catheter sheath (120). Also shown is movable inner core member (122) and the sheath (124) which fits within catheter sheath (120) and supports interlocking clasp (110). Shown in FIG. 3 is the stiffener spring (126) which provides form and support for the distal end of the pusher assembly (118) and in particular rigidly adheres to interlocking clasp (110). Inner core member (122) allows the control wire (106) to be moved axially along the interior of the catheter sheath (120) and the pusher assembly (118). Movement of the inner core member (122) in a proximal direction permits uncoupling of the coil as will be discussed in more detail below.
The length of pusher assembly (118) will be such as to be capable of being advanced entirely through the catheter to place coil (102) at the target site but yet with a sufficient portion of the proximal end of the pusher assembly (118) protruding from the proximal end of the catheter to enable the control wire (106) to be manipulated. For use in peripheral or neural surgeries, the pusher will normally about 100-200 cm in length, more normally 130-180 cm in length. The diameter of the pusher assembly (118) is usually in the range of 0.25 to about 0.90 mm.
As indicated previously, conventional catheter insertion and navigational techniques involving guidewires or flow-directed devices may be used to access the site with a catheter. Once the distal end of the catheter is positioned at the site, often by locating its distal end through the use of radiopaque marker material and radiography, the catheter is cleared. For instance, if a guidewire has been used to position the catheter, it is withdrawn from the catheter and then the pusher assembly (118) having coil assembly (100) at the distal end is advanced through the catheter. The pusher assembly (118) is advanced past the distal end of the catheter so that the coil is free of the catheter and with the coil positioned precisely at the desired treatment site.
As is shown in FIGS. 4 and 5, control wire (106) is withdrawn from the junction between coil interlocking clasp (104) and the other interlocking clasp (110). Coil assembly (100) is then free. The entire catheter may then be removed or the pusher assembly (118) may be withdrawn from the catheter lumen to provide for installation of other coils. If additional coils are to be placed at the target site, the procedure is repeated. After the desired number of coils have been placed at the site, the catheter is withdrawn from the vessel.
FIG. 6A shows a variation in which coil assembly (128) is interlocked with pusher assembly (130) by control wire (106). The depicted coil assembly (128) and pusher assembly (130) are different in that they incorporate the interlocking clasp (132) design shown more clearly in FIG. 6B. The interlocking clasp (132), as with the clasp depicted in FIG. 1B, utilizes an open area (134) within the clasp (132) to accept the mating ramp latch (136) from another similar clasp. The ramp latch (136) typically has a slot (138) and a passageway (140) to permit passage of the control wire through the clasp (132) from the end without obstruction.
The ramp latch (136) allows easy assembly of a string of coils within the catheter for subsequent placement using the device.
Such as assembly process is shown in FIGS. 7A, 7B, and 7C.
FIG. 7A shows a pusher assembly (130) approaching a coil assembly (128) which has been previously placed within a catheter sheath (120). The distal interlocking clasp (132) on the pusher assembly (130) is positioned to interlock with the proximal interlocking clasp (134) on the coil assembly (128).
FIG. 7B shows the two interlocking clasps (132 and 134) as they approach their respective ramps contacting and causing the two clasps to displace axially within the catheter sheath.
FIG. 7C shows the location of the coil assembly (128) and the pusher assembly (132) after the respective clasps are interlocked and the control wire (106) has been placed through the passageways within the clasps.
FIG. 8 shows an elegantly simple variation of the invention in which the pusher (138) is a tubing member having a control wire (106) within its core. The clasp portion (140) is a simple loop comprising, e.g., wire or small rod. The corresponding interlocking loop (142) on the coil (144) forms the junction with the clasp on the pusher.
The variation of the invention shown in FIGS. 6A, 6B, 7A, 7B, 7C, and 8 may be placed within the vasculature in the same manner as shown for the variation shown in FIGS. 4 and 5.
Modifications of the device described above and methods of using it in keeping with this invention that are apparent to those having skill in this mechanical and surgical instrument design art and related fields are intended to be within the scope of the claims which follow.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3334629||9 Nov 1964||8 Aug 1967||Bertram D Cohn||Occlusive device for inferior vena cava|
|US3789841||15 Sep 1971||5 Feb 1974||Becton Dickinson Co||Disposable guide wire|
|US4545390||22 Sep 1982||8 Oct 1985||C. R. Bard, Inc.||Steerable guide wire for balloon dilatation procedure|
|US4619274||18 Apr 1985||28 Oct 1986||Advanced Cardiovascular Systems, Inc.||Torsional guide wire with attenuated diameter|
|US4739768||2 Jun 1986||26 Apr 1988||Target Therapeutics||Catheter for guide-wire tracking|
|US4781177||16 Nov 1987||1 Nov 1988||Promed||Blood clots filtering device|
|US4813934||7 Aug 1987||21 Mar 1989||Target Therapeutics||Valved catheter device and method|
|US4832055||8 Jul 1988||23 May 1989||Palestrant Aubrey M||Mechanically locking blood clot filter|
|US4884579||18 Apr 1988||5 Dec 1989||Target Therapeutics||Catheter guide wire|
|US4957501||27 Dec 1988||18 Sep 1990||Biomat, S.A.R.L.||Anti-embolic filter|
|US4994069||2 Nov 1988||19 Feb 1991||Target Therapeutics||Vaso-occlusion coil and method|
|US5002556||27 Nov 1987||26 Mar 1991||Terumo Kabushiki Kaisha||Balloon catheter assembly|
|US5062829||16 Mar 1990||5 Nov 1991||Carter Holt Harvey Plastic Products Group Limited||Relates to devices for administering a substance such as a drug or chemical or the like|
|US5064434||28 Jan 1991||12 Nov 1991||Haber Terry M||Genitourinary implant|
|US5098440||14 Aug 1990||24 Mar 1992||Cordis Corporation||Object retrieval method and apparatus|
|US5108407||8 Jun 1990||28 Apr 1992||Rush-Presbyterian St. Luke's Medical Center||Method and apparatus for placement of an embolic coil|
|US5109867||19 Apr 1991||5 May 1992||Target Therapeutics||Extendable guidewire assembly|
|US5122136||13 Mar 1990||16 Jun 1992||The Regents Of The University Of California||Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas|
|US5133731||9 Nov 1990||28 Jul 1992||Catheter Research, Inc.||Embolus supply system and method|
|US5167624||9 Nov 1990||1 Dec 1992||Catheter Research, Inc.||Embolus delivery system and method|
|US5174276||20 Nov 1989||29 Dec 1992||Hillway Surgical Limited||Endoscope device for applying an aneurysm clip|
|US5192301||3 Sep 1991||9 Mar 1993||Nippon Zeon Co., Ltd.||Closing plug of a defect for medical use and a closing plug device utilizing it|
|US5217484 *||7 Jun 1991||8 Jun 1993||Marks Michael P||Retractable-wire catheter device and method|
|US5234437||12 Dec 1991||10 Aug 1993||Target Therapeutics, Inc.||Detachable pusher-vasoocclusion coil assembly with threaded coupling|
|US5261916||12 Dec 1991||16 Nov 1993||Target Therapeutics||Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling|
|US5263964||6 May 1992||23 Nov 1993||Coil Partners Ltd.||Coaxial traction detachment apparatus and method|
|US5304195 *||21 Jan 1993||19 Apr 1994||Target Therapeutics, Inc.||Detachable pusher-vasoocclusive coil assembly with interlocking coupling|
|US5350397 *||13 Nov 1992||27 Sep 1994||Target Therapeutics, Inc.||Axially detachable embolic coil assembly|
|EP0341039A1||3 May 1989||8 Nov 1989||Triangle Research And Development Corporation||Transendoscopic implant capsule|
|WO1992014408A1||12 Feb 1992||3 Sep 1992||Malte Neuss||Spiral implant for bodily ducts|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7299975||19 Sep 2006||27 Nov 2007||Datalogic Scanning, Inc.||Add-on capture rate in a barcode scanning system|
|US7331974 *||11 Aug 2003||19 Feb 2008||Microvention, Inc.||Microcoil vaso-occlusive device with multi-axis secondary configuration|
|US7678135||14 Apr 2006||16 Mar 2010||Usgi Medical, Inc.||Compressible tissue anchor assemblies|
|US7695493||9 Jun 2004||13 Apr 2010||Usgi Medical, Inc.||System for optimizing anchoring force|
|US7703459||29 Sep 2004||27 Apr 2010||Usgi Medical, Inc.||Apparatus and methods for mapping out endoluminal gastrointestinal surgery|
|US7704264||17 Nov 2004||27 Apr 2010||Usgi Medical, Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US7722636 *||30 Nov 2005||25 May 2010||Codman & Shurtleff, Inc.||Embolic device delivery system with torque fracture characteristic|
|US7736374||1 Mar 2005||15 Jun 2010||Usgi Medical, Inc.||Tissue manipulation and securement system|
|US7736378||7 May 2004||15 Jun 2010||Usgi Medical, Inc.||Apparatus and methods for positioning and securing anchors|
|US7736379||11 Jul 2005||15 Jun 2010||Usgi Medical, Inc.||Compressible tissue anchor assemblies|
|US7744613||12 Dec 2003||29 Jun 2010||Usgi Medical, Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US7763077||24 Dec 2003||27 Jul 2010||Biomerix Corporation||Repair of spinal annular defects and annulo-nucleoplasty regeneration|
|US7803395||17 May 2004||28 Sep 2010||Biomerix Corporation||Reticulated elastomeric matrices, their manufacture and use in implantable devices|
|US7918845||16 Nov 2004||5 Apr 2011||Usgi Medical, Inc.||Endoluminal tool deployment system|
|US7918869||7 May 2004||5 Apr 2011||Usgi Medical, Inc.||Methods and apparatus for performing endoluminal gastroplasty|
|US7942884||1 Jul 2003||17 May 2011||Usgi Medical, Inc.||Methods for reduction of a gastric lumen|
|US7942898||1 Jul 2003||17 May 2011||Usgi Medical, Inc.||Delivery systems and methods for gastric reduction|
|US7955340||12 Dec 2003||7 Jun 2011||Usgi Medical, Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US8007509||12 Oct 2005||30 Aug 2011||Boston Scientific Scimed, Inc.||Coil assemblies, components and methods|
|US8057511||7 May 2004||15 Nov 2011||Usgi Medical, Inc.||Apparatus and methods for positioning and securing anchors|
|US8062325||31 Jul 2006||22 Nov 2011||Codman & Shurtleff, Inc.||Implantable medical device detachment system and methods of using the same|
|US8066719||18 Nov 2004||29 Nov 2011||Ewers Richard C||Apparatus and methods for forming gastrointestinal tissue approximations|
|US8101197||19 Dec 2005||24 Jan 2012||Stryker Corporation||Forming coils|
|US8152839||9 May 2006||10 Apr 2012||Boston Scientific Scimed, Inc.||Embolic coils|
|US8206417||9 Jun 2004||26 Jun 2012||Usgi Medical Inc.||Apparatus and methods for optimizing anchoring force|
|US8216252||1 Mar 2005||10 Jul 2012||Usgi Medical, Inc.||Tissue manipulation and securement system|
|US8216253||22 Apr 2008||10 Jul 2012||Usgi Medical, Inc.||Apparatus for manipulating and securing tissue|
|US8216260||25 Aug 2008||10 Jul 2012||Usgi Medical, Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US8236009||14 Oct 2009||7 Aug 2012||Usgi Medical, Inc.||Needle assembly for tissue manipulation|
|US8257394||14 Jan 2005||4 Sep 2012||Usgi Medical, Inc.||Apparatus and methods for positioning and securing anchors|
|US8262676||18 Sep 2009||11 Sep 2012||Usgi Medical, Inc.||Apparatus and methods for forming gastrointestinal tissue approximations|
|US8298291||26 Apr 2006||30 Oct 2012||Usgi Medical, Inc.||Methods and apparatus for securing and deploying tissue anchors|
|US8308765||7 May 2004||13 Nov 2012||Usgi Medical, Inc.||Apparatus and methods for positioning and securing anchors|
|US8313454||26 Mar 2010||20 Nov 2012||Optonol Ltd.||Fluid drainage device, delivery device, and associated methods of use and manufacture|
|US8323306||5 Apr 2006||4 Dec 2012||Microvention, Inc.||Microcoil vaso-occlusive device with multi-axis secondary configuration|
|US8328860||11 Dec 2012||Covidien Lp||Implant including a coil and a stretch-resistant member|
|US8342182||27 Aug 2007||1 Jan 2013||Pulmonx Corporation||Functional assessment and treatment catheters and methods for their use in the lung|
|US8343175||26 Apr 2010||1 Jan 2013||Usgi Medical, Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US8366720||31 Jul 2006||5 Feb 2013||Codman & Shurtleff, Inc.||Interventional medical device system having an elongation retarding portion and method of using the same|
|US8388650||5 Mar 2013||Pulsar Vascular, Inc.||Systems and methods for supporting or occluding a physiological opening or cavity|
|US8414927||17 Sep 2007||9 Apr 2013||Boston Scientific Scimed, Inc.||Cross-linked polymer particles|
|US8425550||23 Apr 2013||Boston Scientific Scimed, Inc.||Embolic coils|
|US8444657||28 Apr 2005||21 May 2013||Usgi Medical, Inc.||Apparatus and methods for rapid deployment of tissue anchors|
|US8486086||7 Nov 2011||16 Jul 2013||Optonol, Ltd||Flow regulating implant, method of manufacture, and delivery device|
|US8496006||22 Jun 2010||30 Jul 2013||Pulmonx Corporation||Methods and devices for passive residual lung volume reduction and functional lung volume expansion|
|US8545530||3 Jan 2006||1 Oct 2013||Pulsar Vascular, Inc.||Implantable aneurysm closure systems and methods|
|US8551132||19 Apr 2007||8 Oct 2013||Pulsar Vascular, Inc.||Methods and systems for endovascularly clipping and repairing lumen and tissue defects|
|US8574243||12 Dec 2003||5 Nov 2013||Usgi Medical, Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US8726909||27 Jan 2006||20 May 2014||Usgi Medical, Inc.||Methods and apparatus for revision of obesity procedures|
|US8777978||30 Aug 2011||15 Jul 2014||Covidien Lp||System and method for mechanically positioning intravascular implants|
|US8777979||30 Sep 2011||15 Jul 2014||Covidien Lp||System and method for mechanically positioning intravascular implants|
|US8795320||30 Aug 2011||5 Aug 2014||Covidien Lp||System and method for mechanically positioning intravascular implants|
|US8795321||30 Aug 2011||5 Aug 2014||Covidien Lp||System and method for mechanically positioning intravascular implants|
|US8801747||27 Feb 2008||12 Aug 2014||Covidien Lp||Implant, a mandrel, and a method of forming an implant|
|US8864790||16 Apr 2007||21 Oct 2014||Covidien Lp||System and method for mechanically positioning intravascular implants|
|US8870916||5 Jul 2007||28 Oct 2014||USGI Medical, Inc||Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use|
|US8926634||5 Dec 2007||6 Jan 2015||Usgi Medical, Inc.||Apparatus and methods for manipulating and securing tissue|
|US8945171||29 Sep 2011||3 Feb 2015||Covidien Lp||Delivery system for implantable devices|
|US8979893||22 Feb 2013||17 Mar 2015||Pulsar Vascular, Inc.||Systems and methods for supporting or occluding a physiological opening or cavity|
|US9011480||20 Jan 2012||21 Apr 2015||Covidien Lp||Aneurysm treatment coils|
|US9050094||19 Mar 2009||9 Jun 2015||Pulmonx Corporation||Methods and devices for passive residual lung volume reduction and functional lung volume expansion|
|US9050095||11 Feb 2013||9 Jun 2015||Covidien Lp||Medical implant|
|US9119625||5 Oct 2012||1 Sep 2015||Pulsar Vascular, Inc.||Devices, systems and methods for enclosing an anatomical opening|
|US9149278||13 Mar 2013||6 Oct 2015||DePuy Synthes Products, Inc.||Occlusive device delivery system with mechanical detachment|
|US9173774||11 Sep 2012||3 Nov 2015||Optonol Ltd.||Fluid drainage device, delivery device, and associated methods of use and manufacture|
|US20040045554 *||11 Aug 2003||11 Mar 2004||Dean Schaefer||Microcoil vaso-occlusive device with multi-axis secondary configuration|
|US20040116949 *||11 Aug 2003||17 Jun 2004||Ewers Richard C.||Apparatus and methods for forming gastrointestinal tissue approximations|
|US20040147958 *||25 Sep 2003||29 Jul 2004||Usgi Medical||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US20040225183 *||12 Dec 2003||11 Nov 2004||Usgi Medical||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US20040225305 *||12 Dec 2003||11 Nov 2004||Usgi Medical||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US20050065536 *||18 Nov 2004||24 Mar 2005||Usgi Medical Inc.||Apparatus and methods for forming gastrointestinal tissue approximations|
|US20050075653 *||18 Nov 2004||7 Apr 2005||Usgi Medical Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US20050149108 *||17 Dec 2003||7 Jul 2005||Microvention, Inc.||Implant delivery and detachment system and method|
|US20050203488 *||9 Mar 2004||15 Sep 2005||Usgi Medical Inc.||Apparatus and methods for mapping out endoluminal gastrointestinal surgery|
|US20050203489 *||28 Feb 2005||15 Sep 2005||Usgi Medical Inc.||Apparatus and methods for performing mucosectomy|
|US20050245945 *||17 Nov 2004||3 Nov 2005||Usgi Medical Inc.||Apparatus and methods for forming and securing gastrointestinal tissue folds|
|US20050250984 *||1 Dec 2004||10 Nov 2005||Usgi Medical Inc.||Multiple removable apparatus and methods for manipulating and securing tissue|
|US20050250985 *||1 Dec 2004||10 Nov 2005||Usgi Medical Inc.||Self-locking removable apparatus and methods for manipulating and securing tissue|
|US20050251157 *||7 May 2004||10 Nov 2005||Usgi Medical Inc.||Apparatus and methods for positioning and securing anchors|
|US20050251161 *||30 Sep 2004||10 Nov 2005||Usgi Medical Inc.||Needle assembly for tissue manipulation|
|US20050251162 *||29 Sep 2004||10 Nov 2005||Usgi Medical Inc.||Apparatus and methods for manipulating and securing tissue|
|US20050251165 *||1 Mar 2005||10 Nov 2005||Usgi Medical Inc.||Tissue manipulation and securement system|
|US20050251176 *||7 Apr 2005||10 Nov 2005||Usgi Medical Inc.||System for treating gastroesophageal reflux disease|
|US20050251189 *||29 Sep 2004||10 Nov 2005||Usgi Medical Inc.||Multi-position tissue manipulation assembly|
|US20050251205 *||7 May 2004||10 Nov 2005||Usgi Medical Inc.||Apparatus and methods for positioning and securing anchors|
|US20050251208 *||15 Jun 2004||10 Nov 2005||Usgi Medical Inc.||Linear anchors for anchoring to tissue|
|US20050277966 *||11 Jul 2005||15 Dec 2005||Usgi Medical Inc.||Compressible tissue anchor assemblies|
|US20050277983 *||9 Jun 2004||15 Dec 2005||Usgi Medical Inc.||System for optimizing anchoring force|
|US20060020276 *||23 Jul 2004||26 Jan 2006||Usgi Medical Inc.||Apparatus and methods for achieving prolonged maintenance of gastrointestinal tissue folds|
|US20060135971 *||29 Nov 2005||22 Jun 2006||Usgi Medical Inc.||System for treating gastroesophageal reflux disease|
|US20060184195 *||5 Apr 2006||17 Aug 2006||Microvention, Inc.||Microcoil vaso-occlusive device with multi-axis secondary configuration|
|US20060184196 *||5 Apr 2006||17 Aug 2006||Microvention, Inc.||Microcoil vaso-occlusive device with multi-axis secondary configuration|
|US20060217762 *||14 Apr 2006||28 Sep 2006||Usgi Medical, Inc.||Compressible tissue anchor assemblies|
|US20070083219 *||12 Oct 2005||12 Apr 2007||Buiser Marcia S||Embolic coil introducer sheath locking mechanisms|
|US20070083226 *||12 Oct 2005||12 Apr 2007||Buiser Marcia S||Coil assemblies, components and methods|
|US20070088387 *||3 Jan 2006||19 Apr 2007||Pulsar Vascular, Inc.||Implantable aneurysm closure systems and methods|
|US20070123927 *||30 Nov 2005||31 May 2007||Farnan Robert C||Embolic device delivery system|
|US20070123928 *||30 Nov 2005||31 May 2007||Farnan Robert C||Embolic device delivery system with torque fracture characteristic|
|US20070142859 *||18 Jul 2006||21 Jun 2007||Boston Scientific Scimed, Inc.||Embolic coils|
|US20070142893 *||9 May 2006||21 Jun 2007||Buiser Marcia S||Embolic coils|
|US20070191884 *||19 Apr 2007||16 Aug 2007||Pulsar Vascular, Inc.||Methods and systems for endovascularly clipping and repairing lumen and tissue defects|
|US20070299461 *||21 Jun 2006||27 Dec 2007||Boston Scientific Scimed, Inc.||Embolic coils and related components, systems, and methods|
|US20080051719 *||27 Aug 2007||28 Feb 2008||Pulmonx||Functional assessment and treatment catheters and methods for their use in the lung|
|US20080145658 *||12 Sep 2007||19 Jun 2008||Boston Scientific Scimed, Inc.||Freeze Thaw Methods For Making Polymer Particles|
|US20090270856 *||7 Jul 2009||29 Oct 2009||Usgi Medical, Inc.||Apparatus and methods for performing mucosectomy|
|US20100010457 *||14 Jan 2010||Usgi Medical, Inc.||Apparatus and methods for forming gastrointestinal tissue approximations|
|US20100094335 *||4 Sep 2009||15 Apr 2010||Pulsar Vascular, Inc.||Systems and methods for supporting or occluding a physiological opening or cavity|
|US20120035707 *||9 Feb 2012||Vladimir Mitelberg||Methods of using implantable medical device detachment system|
|US20140214071 *||28 Jan 2013||31 Jul 2014||Neurodynamics, Llc.||Embolic coil delivery system and method of using same|
|WO2008027913A2||28 Aug 2007||6 Mar 2008||Pulmonx||Functional assessment and treatment catheters and methods for their use in the lung|
|U.S. Classification||606/1, 606/151, 128/898, 606/200|
|International Classification||A61F2/01, A61B17/12|
|Cooperative Classification||A61F2002/016, A61F2230/0091, A61B17/12022, A61B2017/1205, A61M25/0905, A61F2002/011, A61F2/01, A61B17/12145|
|European Classification||A61B17/12P7C1, A61B17/12P, A61F2/01, A61M25/09D|