|Publication number||USRE34421 E|
|Application number||US 07/870,145|
|Publication date||26 Oct 1993|
|Filing date||17 Apr 1992|
|Priority date||21 Nov 1990|
|Also published as||EP0560906A1, EP0560906A4, US5090043, WO1992009998A1|
|Publication number||07870145, 870145, US RE34421 E, US RE34421E, US-E-RE34421, USRE34421 E, USRE34421E|
|Inventors||William J. Parker, Earl R. Parker|
|Original Assignee||Parker William J, Parker Earl R|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Non-Patent Citations (2), Referenced by (91), Classifications (13), Legal Events (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
1. Field of the Invention
This invention relates to the production and medical use of X-rays, and more particularly to the production, by X-ray micro-tubes, of low energy, highly absorable, polychromatic X-rays and to the use of those X-rays in the treatment of tumors when such X-rays micro-tubes are placed within, or adjacent to, mammalian bodies in very close proximity to, or within, tumors.
2. Description of Related Art
Its has been stated that the goal of radiation therapy is to achieve in a selected treatment volume, a dose distribution of radiation that provides the patient with maximum tumor control and the least possible effect on surrounding normal tissues. (PRINCIPLES AND PRACTICE OF RADIATION ONCOLOGY, C. A. Perez, and L. W. Brady, Editors; J. B. Lippincott Company, Philadelphia. 1987 Pg. 159).
To achieve that desired goal, many methods have been advanced over the last 90 or so years which have focused on the use of very high energy sources of radiation. Current radiation treatment of tumors involves the use of large external high energy devices such as X-ray machines, linear accelerators, betatrons, or microtrons, or the use of very high energy emissions from radiosotopes.
the radioisotopes may be placed in large external machines such as 60 Cobalt teletherapy machine, or implanted near a tumor site. Present Applicants are aware of a surgical procedure being utilized in the treatment of brain tumors in which tiny holes are drilled in the skull. The surgeon inserts thin tubes with closed bottom ends into the tumor. Radioactive pellets the size of peas are inserted into the tubes. The implants deliver strong radiation to the tumor. They are removed few days later.
The safety of these above-identified high energy radiation sources has been a constant concern for health professionals. Not only can the tumor and surrounding normal tissue within the patient be affected by these high energy radiation sources, but the health professionals working near the patient can be adversely affected if adequate safeguards are not taken.
Although the high energy devices have been designed to produce a maximum of antitumor activity with a minimal effect on a patient's normal tissues, the side effects of the radiation therapy on the patient's normal tissue can still be the limiting factor in a course of therapy.
The present invention is a method and apparatus for treating tumors by low energy, highly absorbable, polychromatic X-rays (also called Bremsstrahlung or White radiation) produced by small X-ray micro-tubes placed within, or adjacent to, a patient's body in close proximity to, or within, a tumor. The design of the X-ray micro-tube can be relatively simple: a miniature X-ray production source, generally a glass tube a fraction of an inch in diameter and with a length of approximately one-half of an inch, to several inches, containing at least an anode and a cathode. The cathode may be a pointed cold cathode, or a heated filament, and the tube must be evacuated to, at most, 10-6 Torr. The target portion of the anode may be formed of tungsten, as in conventional X-ray tubes. The glass tube may be surrounded by a plastic envelope so as to prevent injury to the patient or health professional should the glass break. A metal jacket containing a window may be placed around the tube so as to allow the X-rays to travel only in the direction of the tumor. The X-ray micro-tube may be disposable or re-sterilized.
The depth of X-ray penetration into tissues can be easily and accurately controlled by adjusting the voltage applied to the X-ray micro-tube. Tissue penetration depths within a few centimeters from the surface of the tube are characteristic of the White radiation produced by the micro-tubes. This reduces damage to normal tissue except in the immediate vicinity of the tumor. The X-rays are produced by applied voltages between 10 kilovolts and 60 kilovolts.
The voltage applied to the X-ray micro-tube may have an operable frequency between direct current and 1,000,000 cycles per second, the higher frequencies providing greater patient safety. The current through the X-ray micro-tube is generally much lower than that conventionally used and is in the micro-ampere range. Patient safety is assured by ground fault interrupters and current limiting circuitry.
The micro-X-ray tubes may be place in-situ by a number of methods, including, but not limited to: implantation during surgery; insertion through a normal body orifice; insertion in conjunction with a fiber-optic scope through a normal body orifice; in conjunction with a fiber-optic scope through a surgical incision; insertion through a trocar catheter; or insertion through a catheter contained within a surgical incision.
Other objects advantages and novel features of the present invention will become apparent from the following detailed description of the invention when considered in conjunction with the accompanying drawings.
FIG. 1 is a graph of Mass Absorption Coefficient, μ/ρ, versus Energy, MeV, showing the ranges for Photoelectric and Compton Scattering absorption.
FIG. 2 is a graph illustrating the spectral distribution of the X-ray energies and relative intensities emitted from a tungsten anode for various constant d.c. potentials.
FIG. 3 is a graph illustrating examples of Penetration-depth curves of constant d.c. voltage, KeV vs penetration depth in body tissue, in centimeters, for monochromatic X-rays, showing distance for percentage of intensity remaining.
FIG. 4 includes schematic curves showing the changes in the intensity distribution of the White radiation spectrum from a tungsten anode at 50 KeV constant potential d.c. after penetrating through various depths of tissue.
FIG. 5 includes schematic curves showing the changes in the intensity distribution of the White radiation spectrum from a tungsten anode at 40 KeV constant potential d.c. after penetrating through various depths of tissue.
FIG. 6 includes schematic curves showing the changes in the intensity distribution of the White radiation spectrum from a tungsten anode at 30 KeV constant potential d.c. after penetrating through various depths of tissue.
FIG. 7 includes schematic curves showing the changes in the intensity distribution of the White radiation spectrum from a tungsten anode at 25 KeV constant potential d.c. after penetrating through various depths of tissue.
FIGS. 8A to 8J illustrate short X-ray micro-tube designs.
FIG. 8A illustrates a short micro-tube with a heated filament cathode.
FIG. 8B illustrates a short micro-tube with a cold cathode electron emitter.
FIG. 8C illustrates a very short micro-tube having the cathode and anode positioned on the same end, with an internal glass tube for insulating the anode connecting wire.
FIGS. 8D(a) and 8D(b) illustrate the use of a thin internal anode film on the inside of the glass tube through which X-rays can penetrate to produce a cylindrical transmitted X-ray beam.
FIGS. 8E(a) and 8E(b) illustrate the use of a thick internal anode film on the inside of the glass tube, the resulting back-scattered X-ray beam producing a hemicylindrical X-ray pattern.
FIGS. 8F(a) and 8F(b) illustrate the use of a thin internal anode film on the inside of the glass tube resulting in a hemicylindrical transmitted X-ray pattern.
FIG. 8G illustrates a short micro-tube with a spot-type anode (thick or thin).
FIGS. 8H(a) and 8H(b) illustrate the use of a thin internal hemispherical anode film used to produce a hemispherical X-ray pattern.
FIG. 9 illustrates a long micro-tube design with an enlarged end for evacuation and sealing.
FIG. 10 is a schematic illustration of a short liquid-cooled microtube assembly.
FIG. 11 is a schematic illustration of a short metal-jacketed microtube assembly.
The same elements or parts throughout the figures of the drawings are designated by the same reference characters.
An understanding of X-ray interaction with tumors requires some background understanding of the physical phenomena involved. Electromagnetic radiation extends over a very wide range of wave lengths, i.e. from radio waves (3×104 m to 5 m), microwaves (5×10-2 m to 1×10-4 m), infrared (1×10-4 m 7×10-7 m), visible (7×10-7 m to 4×10-7 m), ultra-violet (4×10-7 m to 1×10-8 m), X-rays and gamma rays (1×10-8 m to 1×10-14 m). The wave lengths of X-rays are frequently expressed in angstroms (Å) with 1 Å being equal to 10-8 cm. These selected wave length bands of radiation have been classified as ranges which interact with matter in familiar ways. The value of the wavelength determines the size of an object with which the electromagnetic radiation will react. Radio waves will react with large electrical conductors, visible and ultra-violet light react with the outer shell electrons in atoms, and X-rays interact with the innermost orbital electrons. The shorter the wavelength the higher the energy of the radiation. The reciprocal of the wavelength is the frequency, with the wavelength commonly being represented by the symbol λ, and the frequency by the Greek letter ν. The energy, E, is equal to ην, where η is Planck's constant.
The nature and properties of the radiation within the X-ray band vary with the energy (or wavelength) of the X-ray, just as the characteristics of the light in the visible range vary with the wave length of the radiation, the shorter wave lengths appearing as blue colors and the longer ones as orange-red colors. A brief discussion of how the different wave lengths of X-rays are produced and how they differ in their interactions with body tissues provides an understanding of the uniqueness and value of the present invention.
Medically useful X-rays are normally produced in evacuated tubes (usually made of glass) containing two elements, a cathode and an anode. The cathode is typically a tungsten filament that is heated to a temperature sufficiently high to cause electrons to reach velocities permitting them to escape from the filament. The escaping electrons are attracted to the anode at the opposite end of the tube (also typically formed of tungsten), which exists at a high positive potential, commonly in the range of 50,000 to 2 million volts.
The electrons are accelerated during their passage toward the anode, reaching a high velocity before colliding with the anode and causing inner shell electrons to be ejected from the tungsten atoms. When the high energy ejected to be ejected electrons return to normal positions in electron shells, X-rays are created. The energy gained by the participating electrons is measured in electron volts (eV) where e is the electrical charge of the electron and V is the voltage difference between the cathode and the anode. This measurement of energy is commonly used in the field of X-ray diagnosis and therapy. (For the purpose of comparison, one electron volt of energy per atom is equivalent to 23 kilocalories per mole of atoms).
In the X-ray range of wave lengths, several different phenomena occur when matter is exposed to X-rays. These phenomena are known as Elastic (or Coherent) Scattering, Photoelectric Absorption, Compton Scatter, and Electron Pair Production (one electron and one position). When the energy of the photon is less than the binding energy of the outer shell electrons of the exposed material, the photons cause the orbiting electrons to oscillate in phase with the X-ray and thus to emit electromagnetic radiation of the same frequency as the incident ray. The re-radiated X-rays are scattered with no absorption in the irradiated matter. This phenomenon, called Elastic or Coherent Scattering, is of no consequence in X-ray diagnosis or therapy. Electron Pair Production only occurs at extremely high energies i.e., above one million electron volts (1 MeV), which is much higher than the energies used in this invention. Thus, these two phenomena will not be further discussed herein.
Photoelectric Absorption is the dominant form of X-ray absorption only in the lowest range of X-rays (e.g. 10 to 60 kilovolts). It occurs when the energy of the X-ray photons is equal to the energy binding the innermost shell electrons of the atoms in the exposed matter. In this case, the X-ray photons interact with the electrons orbiting closest to the nucleus, causing them to be ejected from the atoms, and causing the photons to loose all of their energy and disappear. This reaction cannot occur at X-ray beam energies below the electron-atom binding energy. It is a maximum when the two energies are equal, and decreases rapidly with increasing X-ray energy above the maximum value.
Absorption of higher energy X-ray radiation (e.g. above 100 KeV) occurs almost entirely by Compton Scattering. This process involves the interactions of X-ray photons with any of the electrons in the cloud surrounding the nucleus of the interacting atom. In this case, an incident photon loses only part of its energy when it reacts with an electron, which acquires the energy lost by the photon and is ejected from the electron cloud of the atom. The resulting photon with diminished energy is scattered and moves forward at some angle to the line of the incident beam. The energy of the scattered photon is not absorbed locally within the exposed material during this event, but the energy acquired by the participating electron is completely absorbed within the material. Thus, the energy change of the incident X-ray beam is divided into two parts, only one of which is directly absorbed.
Between 10 KeV and 100 KeV the absorbed fraction of Compton energy increases from a low value at 10 KeV, finally reaching a high value at 100 KeV, thereafter changing by a relatively small amount in the range between 100 KeV and 1 MeV as shown on the mass absorption coefficient vs energy curves in FIG. 1. (FIG. 1 is prior art adapted from "Principles of Radiological Physics" by Robin J. Wilkes. Second Edition, Pg. 483. Churchill Livingstone, N.Y. 1987.) In this figure there are curves showing how the absorption of X-rays by tissue and bone vary with photon energy. Below about 50 KeV energy (in the Photoelectric Absorption range), bones absorb about 13 times as much of the incident energy as does tissue. Above about 100 KeV (in the Compton range) the difference is very small, with bone absorption being only about 1.7 times as much as tissue. The higher energy range is generally used for cancer therapy.
The photoelectric absorption of 10 KeV X-rays by tissue is very high, but the absorption coefficient decreases drastically as the energy is increased. At 50 KeV the absorption coefficient has decreased to about one percent of the 10 KeV value. In the 10 KeV to 50 KeV range in which Photoelectric Absorption is dominant. These lower energy X-rays penetrate only short distances into tissue and consequently this is not normally considered to be useful range for either medical diagnosis or therapy. It is common practice in radiation therapy to remove as much as possible of this skin damaging radiation from the X-ray beam. This is accomplished by inserting thin sheets of aluminum or copper in the path of the beam to absorb as much as possible of the low energy component of the beam. The present invention makes it possible to utilize some of the X-rays in this low energy range to treat some easily accessible cancerous tissue more effectively than the higher energy methods now in use, but without the sometimes severe damage to normal body tissue that occurs with currently used practices.
Before entering into the detailed description of the new method and equipment which are the subject of this invention, a brief description of some of the well known characteristics and methods of utilizing X-rays is considered. For example, traditional plots of absorption coefficients versus X-ray energies, such as illustrated in FIG. 1, refer to monochromatic X-rays, whereas the radiation from an X-ray tube actually comprises a broad spectrum of energies, as illustrated by FIG. 2. (FIG. 2 is prior art adapted from "X-Ray Metallography" by A. Taylor, pg. 18, John Wiley and Sons, New York, 1961)
In this figure relative (X-ray) intensity is plotted against (X-ray) energy for various constant d.c. tube voltages, and spectral curves of Bremsstrahlung or White radiation are thus produced. The shapes of these curves are affected by tube potential. The shapes of the curves are also affected by the nature of the power source. Depending upon the design of the power supply, the output may be constant d.c., a half-wave rectified a.c., or a full wave rectified a.c.. The maximum intensities and the X-ray energy distribution will be different for each type of power source. Also, it must be remembered that the mass absorption coefficient for tissue varies sharply with the energy (or wave length) of the X-ray, as shown in FIG. 1. In reality, then, the effective absorption coefficient for a beam consisting of a broad spectrum of X-rays is the fraction of the beam that is absorbed during the passage of the beam through one centimeter of material and is composed of two parts: one being the component contributed by Photoelectric Absorption, and the other being due to the Compton effect.
FIG. 3 shows examples of approximate depth of penetration curves (i.e. the distance through material which causes a specific decrease in the X-ray intensity to, for example, 1/2, 1/4, 1/10 etc. of the initial beam intensity. I is the intensity, while Io refers to the initial intensity). The values shown in this figure are for monochromatic radiation. From accurate plots of the mass absorption coefficients, μ/ρ, versus energy curves shown in FIG. 1, the linear absorption coefficient, μ, needed for calculating the decrease in X-ray intensity versus penetration distance, as shown in FIG. 3, can be obtained by assuming that the intensity, ρ, of tissue used for defining mass absorption coefficient, μ/ρ, is equal to 1. FIG. 3 highlights the fact that in the 10-50 KeV range X-rays simply do not penetrate very far.
As an example of the method used to obtain the curves in FIG. 3, assuming the voltage to be 50 KeV, the value of I/Io =0.5, and μ, the absorption coefficient=0.24, the interrelationship of these parameters is given by I/Io =e-μx where x is the penetration distance below the surface of the absorbing material (x is a negative number). Substituting the numbers given above in the equation yields a value of x of 2.87 cm (corresponding to the value for the x=2.87 cm at 50 KeV and 50% absorption in FIG. 3).
The actual radiation being emitted from the anode on an X-ray tube with, for example, 50 kilovolts applied potential, is actually a whole spectrum of radiant energies, producing what is commonly called "white" radiation. This is illustrated in FIG. 2, which shows the distribution of energies (in KeV) for a tube with a tungsten anode, when exposed to various constant tube voltages. In spectra of this sort, each individual value would have an absorption coefficient differing from those of the other energies in the spectrum. The variation in absorption coefficients within the spectrum must be taken into account when effective absorption is calculated for the beam. In the lower end of the voltage range, i.e., below about 50 KeV tube voltage, the absorption coefficients may vary by more than 100 to 1 (see FIG. 1). However, in the higher voltage range currently in general use (i.e., about 100 KeV to 1 MeV) the absorption coefficient is relatively constant. With white radiation in the energy range of this invention, then, both the absorption coefficient and the X-ray intensity are strongly dependent upon the energy of the photons involved. For example, the mass absorption coefficient for tissue varies from about 0.33 for 37 KeV to 3.3 at 12 KeV.
FIGS. 4, 5, 6, and 7 show intensity decreases in the initial intensity values for white radiation from a tungsten anode X-ray tube at different tube potentials, as the beam penetrates into tissue. The shape of the Relative Intensity versus Energy (KeV) curve changes as the distance from the outer surface of the tissue being penetrated is increased. At each X-ray energy level the absorption coefficient differs, as shown in FIG. 1, with a much higher fraction of the lower X-ray energy components of the white radiation beam being absorbed than is the case for the higher energy components. The curves in FIG. 4 illustrate this effect at various depths in tissue.
Examples of how and why the shapes of the white radiation energy distribution curves change at different depths in tissue will be helpful in understanding the curves plotted in FIGS. 4, 5, 6, and 7. FIG. 4 illustrates examples of the nature of the changes that occur at a high energy value within the 50 KeV generated white radiation spectrum, to those of a low energy value of the same spectrum, by comparing initial intensities on the Io curve to intensities on the same depth in tissue curve.
In this example, let the high energy case by chosen as 42 KeV and the low energy be selected as 20 KeV. For the high energy case (42 KeV), let: Io =5.5 (from FIG. 4), μ=0.32 (from FIG. 1), and x=1 cm.
By rearranging the formula, I/Io =e-μx, we can solve for the value of I at 1 cm using our parameters:
IIcm =IO e-μx
which is shown on FIG. 4.
Now, for the low energy case (20 KeV), let: Io =9.5 (from FIG. 4), μ=0.87 (from FIG. 1), and x=1 cm.
In this case, we have:
which is shown on FIG. 4.
This demonstrates that for equal intensities at a penetration depth of one centimeter, the initial intensity, Io, had to be only 5.5 for the higher voltage (42 KeV) while the Io value for 20 KeV had to be much higher at 9.5. Thus, FIG. 4 further highlights the advantage of the use of these low energy X-rays. They do not penetrate very far. The low energy portions of the spectra illustrated in FIG. 4 are almost entirely absorbed at 3 cm.
FIGS. 5-7 are generated in the same manner as FIG. 4 but for constant potential d.c. voltages of 40 KeV, 30 KeV, and 25 KeV, respectively. Information of this kind is necessary for determining suitable voltages for treating tumors of different varieties and sizes while minimizing damage to nearby tissues.
The micro-tubes are similar in principle to standard X-ray tubes except that they are much smaller and require only a small fraction of the tube current required in conventional commercial machines (i.e. microamperes vs milliamperes). The physical size of a tube can be a fraction of an inch in diameter and with a length as small as one-half of an inch, to as long as several inches. A variety of useful tube designs is possible.
Referring now to FIG. 8a, a schematic illustration of an embodiment having a filament cathode is shown, designated generally as 20. An evacuated glass tube 22 contains a stable vacuum of at least 10-6 Torr. A heated filament cathode 24 (preferably a small tungsten filament) and an anode 26 are provided which are connected to an appropriate power source (as will be discussed below). The anode 26 can be made of any one of a number of different metals typically used, but tungsten is preferred (as it is conventional commercial tubes).
Referring to FIG. 8b, a second type of X-ray tube that is suitable for micro-tube use is schematically illustrated, designated generally as 28. Tube 28 is a cold emission (or field emission) cathode tube (which has no filament). The electrons are emitted from a sharply pointed electrode 30, preferably formed of tungsten. A very high potential gradient develops between the sharply pointed tip of the electrode and the anode 32 when a high voltage is applied across the X-ray tube 28. For micro-tube use in radiation oncology, use of a cold electron emitter tube has some advantages. This type of tube is simpler to make in smaller sizes than the heated filament type.
The depth of penetration of the present X-ray microtubes can be easily controlled by varying the tube voltage. The total desired radiation exposure can be controlled by selecting an appropriate time of exposure. A great advantage of the micro-tube is that it can be placed on or very near the surface of the tumor, or within the tumor, so that radiation damage to normal tissue is minimized.
The source to tumor distance for the micro-tubes, therefore, is extremely small compared with the source to skin distance (SSD) of 20 to 50 centimeters with the X-ray units now in common use. Since the intensity of the X-ray beam varies inversely with the square of the distance from the beam source, for a given tube voltage, the same effective intensity of the X-ray beam at the site of a tumor can be produced by the micro-tube with about one one-thousandth of the current required for the proper operation of a large external tube. Therefore, the present invention operates in the low microampere range, rather than the low milliampere range required for currently used large tubes.
Micro-tubes are relatively inexpensive and may be manufactured to be re-sterilized or disposable. The exterior surface of the tube is preferably covered with a thin tough biocompatible plastic material, as will be described below, to guard against damage to handlers or patients should accidental breakage of the glass tube occur. The plastic tube cover can also have a built-in water coolant jacket to dissipate the small amount of heat generated by the tube (operating at a small fraction of a watt).
The power supply required is relatively simple and inexpensive because of the low current required (microamperes vs conventionally used milliamperes) and because of the relatively low tube voltages required (generally less than 60 kilovolts compared 60 kilovolts to one million volts for conventional equipment). Aside from the micro-tube itself, only state of the art equipment is necessary. However, one difference in detail is necessary. Conventional 60 cycle a.c. destroys the many normal nerve functions. The inventive concepts of the present invention provide for use of a frequency that would be sufficiently high so that the normal nerve functions of the body would not be affected if an inadvertent contact of the high voltage lead with body tissue did occur. The use of high frequency currents in electrosurgical cutting and coagulation machines is common and has long been known to be safe (see for example, U.S. Pat. No. 3,699,967, entitled "Electrosurgical Generator", and Chapter 3, Electrosurgery, Handbook of Biomedical Engineering, 1988, Academic Press). Furthermore, use of such high frequencies provides the ability for the patient to act as a conduit for return of the anode current back to the power supply if that anode is not directly connected to the power supply.
FIG. 8C illustrates the placement of the anode 34 and the cathode 36 on the same side of a microtube 38 to accomplish a reduced length. An internal glass tube 40 is used to support the anode 34 and to insulate the anode connecting wire 42.
The micro-tubes of the present invention may be manufactured in a variety of different ways to optimize their use. For example, in FIG. 8D(a) a glass micro-tube 42 is illustrated with a thin internal anode film 44 formed on its inner surface (preferably vacuum deposited tungsten). An axially extending filament cathode 46 is provided. Thus, when operated, a cylindrical X-ray pattern, illustrated by the arrows 48 in FIG. 8D(b), results. This design is particularly useful if the microtube is desired to be inserted near the center of the tumor.
FIGS. 8E(a) and 8E(b) illustrate a relatively thick film anode 50 deposited or otherwise formed on portions of the inside of the glass tube 52. This results in a backscattered X-ray beam which produces a hemicylindrical X-ray pattern, as illustrated by arrows 54. The X-ray pattern is established at portions of the micro-tube which do not have the thick film formed thereon.
In the micro-tube illustrated in FIG. 8F(a) and 8F(b) a thin anode film 56 is formed on only a portion of the micro-tube 58. This results in a hemicylindrical X-ray pattern 60.
An alternate anode design is illustrated in FIG. 8G, the micro-tube being designated as 62. In this instance, the anode 64 is a spot type of thin or thick film.
In FIGS. 8H(a) and 8H(b) a hemispherical X-ray pattern 66 results from formation of an anode film 68 near the end of the micro-tube 70.
The short micro-tubes illustrated in FIGS. 8A-8H are typically from one-fourth inch to two inches in length, preferably approx. 1/2". Diameters may range from 1/8" to 1", preferably 1/4". As noted, these microtubes may be placed in-situ by a number of methods, including, implantation during surgery; insertion through a normal body orifice; insertion in conjunction with a fiber-optic scope through a normal body orifice; insertion in conjunction with a fiber-optic scope through a surgical incision; insertion through a trocar catheter; or insertion through a catheter contained within a surgical incision. The micro-tubes may also be placed adjacent to the body next to the skin.
Longer micro-tubes may alternately be used which may be up to several inches (i.e. 2"-8") in length. FIG. 9 illustrates a schematic of a design of such a long micro-tube 72. The lead wire 74 for the cathode 76 and the lead wire 78 for the anode 80 connect to a power supply (not shown). Long micro-tube 72 is particularly useful in the brain and is made thin, for example, in the range of 1/8" to 1/4" in diameter. End 82 is enlarged and extends outside of the body, serving as a "compass" for accurately rotating the micro-tube and directing the X-rays in the desired manner. It is understood that the various features shown in the previous Figures may be implemented in the longer tubes of FIG. 9. Further, it is understood that FIGS. 8 and 9 are meant only to be schematic representations of possible micro-tube designs. Obviously, biocompatible safety shields would be utilized to enclose the tubes in actual applications.
The principles of the present invention are preferably implemented with the micro-tubes being used as part of a mechanically shielded and electrically insulated assembly. Referring now to FIG. 10, such an implementation in the form of a short liquid-cooled micro-tube assembly, designated generally as 84, is illustrated. Liquid-cooled micro-tube assembly 84 includes a filament cathode 86 supported by a filament support structure 88 within an evacuated glass tube 90. Similarly, an anode 92 is supported by another filament support structure 94 within the evacuated glass tube 90. Glass tube 90 may be formed as described in the above-discussion regarding FIGS. 8 and 9. Glass tube 90 is positioned within a liquid coolant chamber 96 which is supplied by coolant hoses 98,100. (Water would be a suitable coolant. The walls of the coolant chamber may be formed of, for example, glass or plastic). Coolant chamber 96 is, in turn, enclosed within the main housing 102 of the micro-tube assembly 84. Housing 102 is preferably formed of plastic. Filament lead wires 104,106, anode lead wire 108, and coolant hoses 98.100, extend through the main housing 102. These five elements are preferably radially spaced and separated by walls to confine any leaks to a specific portion of the assembly. Dashed lines 110 schematically illustrate these walls. Additionally, approximately water seals 112 are provided.
A metal-jacketed micro-tube assembly, designated generally as 114, is illustrated in FIG. 11. Assembly 114 includes a cathode 116 supported by a cathode support structure 118 within an evacuated glass tube 120. Similarly, an anode 122 is supported by another support structure 124 within the evacuated glass tube 120. Glass tube 120 is contained within a metal jacket 126. Tube 120 may be formed as described in the above-discussion regarding FIGS. 8 and 9. A window 128 is provided in the metal jacket 126 for directing the radiation in the desired manner. Anode and cathode cables 130,132 including lead wires are provided for attachment to an external power source (not shown).
The power supply needed for X-ray micro-tube operation is unique in that it is a low energy device that can be made easily portable and is less costly to make than those now supplied with deep therapy equipment, which require much higher levels of energy. Modern electronic designs and equipment capable of providing the currents and voltages needed for the operation of the micro-tubes are state of the art, and a variety of designs are available. Another essential feature of the invention is that the power supply circuit must contain a rapidly acting safety circuit interrupter that will immediately operate should anything happen to cause the tube current to suddenly increase to, for example, one milliampere, which is still very safe for a patient but undesirable for micro-tube operation.
Obviously, many modifications and variations of the present invention are possible in light of the above teachings. It is therefore to be understood that, within the scope of the appended claims, the invention may be practiced otherwise than as specifically described.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1881448 *||15 Aug 1928||11 Oct 1932||Formell Corp Ltd||X-ray method and means|
|US3714486 *||7 Oct 1970||30 Jan 1973||Mc Crary J||Field emission x-ray tube|
|US4701941 *||7 Feb 1984||20 Oct 1987||Commonwealth Scientific And Industrial Research Organization (Csiro)||Radiation source|
|1||*||Dunlee OL 1 DL 7, Stationary Anode Isert, Brochures, Jun. 1972.|
|2||Dunlee OL-1-DL-7, Stationary Anode Isert, Brochures, Jun. 1972.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5452720 *||9 Aug 1993||26 Sep 1995||Photoelectron Corporation||Method for treating brain tumors|
|US5528652 *||5 Aug 1994||18 Jun 1996||Photoelectron Corporation||Method for treating brain tumors|
|US5630426 *||3 Mar 1995||20 May 1997||Neovision Corporation||Apparatus and method for characterization and treatment of tumors|
|US5729583 *||29 Sep 1995||17 Mar 1998||The United States Of America As Represented By The Secretary Of Commerce||Miniature x-ray source|
|US5854822 *||25 Jul 1997||29 Dec 1998||Xrt Corp.||Miniature x-ray device having cold cathode|
|US6069938||27 Apr 1998||30 May 2000||Chornenky; Victor Ivan||Method and x-ray device using pulse high voltage source|
|US6095966||20 Feb 1998||1 Aug 2000||Xrt Corp.||X-ray device having a dilation structure for delivering localized radiation to an interior of a body|
|US6108402||16 Jan 1998||22 Aug 2000||Medtronic Ave, Inc.||Diamond vacuum housing for miniature x-ray device|
|US6289079||23 Mar 1999||11 Sep 2001||Medtronic Ave, Inc.||X-ray device and deposition process for manufacture|
|US6312428||12 Jul 1999||6 Nov 2001||Neothermia Corporation||Methods and apparatus for therapeutic cauterization of predetermined volumes of biological tissue|
|US6320935||28 Feb 2000||20 Nov 2001||X-Technologies, Ltd.||Dosimeter for a miniature energy transducer for emitting X-ray radiation|
|US6324257||3 Jun 1999||27 Nov 2001||X-Technologies Inc.||Radiotherapeutical device and use thereof|
|US6353658||8 Sep 1999||5 Mar 2002||The Regents Of The University Of California||Miniature x-ray source|
|US6377846||21 Feb 1997||23 Apr 2002||Medtronic Ave, Inc.||Device for delivering localized x-ray radiation and method of manufacture|
|US6421416||11 Feb 2000||16 Jul 2002||Photoelectron Corporation||Apparatus for local radiation therapy|
|US6463124||19 Jun 2000||8 Oct 2002||X-Technologies, Ltd.||Miniature energy transducer for emitting x-ray radiation including schottky cathode|
|US6480568||19 Jun 2001||12 Nov 2002||Photoelectron Corporation||Optically driven therapeutic radiation source|
|US6480573||4 Dec 2001||12 Nov 2002||Photoelectron Corporation||Therapeutic radiation source with increased cathode efficiency|
|US6493419||19 Jun 2001||10 Dec 2002||Photoelectron Corporation||Optically driven therapeutic radiation source having a spiral-shaped thermionic cathode|
|US6537195||7 May 2001||25 Mar 2003||Xoft, Microtube, Inc.||Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia|
|US6648810 *||9 Nov 2000||18 Nov 2003||Radi Medical Technologies Ab||Medical device|
|US6658086||19 Jun 2002||2 Dec 2003||Carl Zeiss||Optically driven therapeutic radiation source with voltage gradient control|
|US6661876 *||29 Jul 2002||9 Dec 2003||Moxtek, Inc.||Mobile miniature X-ray source|
|US6721392||4 Dec 2001||13 Apr 2004||Carl-Zeiss-Stiftung||Optically driven therapeutic radiation source including a non-planar target configuration|
|US6799075||22 Aug 1996||28 Sep 2004||Medtronic Ave, Inc.||X-ray catheter|
|US6920202||4 Dec 2001||19 Jul 2005||Carl-Zeiss-Stiftung||Therapeutic radiation source with in situ radiation detecting system|
|US7018371||7 May 2001||28 Mar 2006||Xoft, Inc.||Combination ionizing radiation and radiosensitizer delivery devices and methods for inhibiting hyperplasia|
|US7035379||12 Sep 2003||25 Apr 2006||Moxtek, Inc.||Radiation window and method of manufacture|
|US7041046||7 May 2001||9 May 2006||Xoft, Inc.||Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia|
|US7127033 *||28 Feb 2004||24 Oct 2006||Xoft, Inc.||Miniature x-ray tube cooling system|
|US7158612||21 Feb 2003||2 Jan 2007||Xoft, Inc.||Anode assembly for an x-ray tube|
|US7200203||6 Apr 2004||3 Apr 2007||Duke University||Devices and methods for targeting interior cancers with ionizing radiation|
|US7233647||25 Apr 2006||19 Jun 2007||Moxtek, Inc.||Radiation window and method of manufacture|
|US7338487||20 Nov 2001||4 Mar 2008||Medtronic Vascular, Inc.||Device for delivering localized x-ray radiation and method of manufacture|
|US7382862||28 Sep 2006||3 Jun 2008||Moxtek, Inc.||X-ray tube cathode with reduced unintended electrical field emission|
|US7428298||30 Mar 2006||23 Sep 2008||Moxtek, Inc.||Magnetic head for X-ray source|
|US7526068||18 Jun 2002||28 Apr 2009||Carl Zeiss Ag||X-ray source for materials analysis systems|
|US7529345||18 Jul 2007||5 May 2009||Moxtek, Inc.||Cathode header optic for x-ray tube|
|US7686755||30 Mar 2010||Xoft, Inc.||Radiation therapy apparatus with selective shielding capability|
|US7726318||20 Mar 2006||1 Jun 2010||Xoft, Inc.||Radiation blocking patch for radio-therapy|
|US7737424||1 Jun 2007||15 Jun 2010||Moxtek, Inc.||X-ray window with grid structure|
|US7756251||26 Sep 2008||13 Jul 2010||Brigham Young Univers ity||X-ray radiation window with carbon nanotube frame|
|US7983394||17 Dec 2009||19 Jul 2011||Moxtek, Inc.||Multiple wavelength X-ray source|
|US8058612||1 Feb 2010||15 Nov 2011||Georgia Tech Research Corporation||Microirradiators and methods of making and using same|
|US8247971||15 Aug 2011||21 Aug 2012||Moxtek, Inc.||Resistively heated small planar filament|
|US8295440||5 Oct 2010||23 Oct 2012||Korea Advanced Institute Of Science And Technology||Super miniature X-ray tube using NANO material field emitter|
|US8498381||7 Oct 2010||30 Jul 2013||Moxtek, Inc.||Polymer layer on X-ray window|
|US8526574||24 Sep 2010||3 Sep 2013||Moxtek, Inc.||Capacitor AC power coupling across high DC voltage differential|
|US8736138||26 Sep 2008||27 May 2014||Brigham Young University||Carbon nanotube MEMS assembly|
|US8750458||30 Nov 2011||10 Jun 2014||Moxtek, Inc.||Cold electron number amplifier|
|US8761344||29 Dec 2011||24 Jun 2014||Moxtek, Inc.||Small x-ray tube with electron beam control optics|
|US8792619||23 Mar 2012||29 Jul 2014||Moxtek, Inc.||X-ray tube with semiconductor coating|
|US8804910||30 Nov 2011||12 Aug 2014||Moxtek, Inc.||Reduced power consumption X-ray source|
|US8817950||11 Jun 2012||26 Aug 2014||Moxtek, Inc.||X-ray tube to power supply connector|
|US8929515||6 Dec 2011||6 Jan 2015||Moxtek, Inc.||Multiple-size support for X-ray window|
|US8948345||17 Jan 2013||3 Feb 2015||Moxtek, Inc.||X-ray tube high voltage sensing resistor|
|US8964943||5 Dec 2012||24 Feb 2015||Moxtek, Inc.||Polymer layer on X-ray window|
|US8989354||23 Apr 2012||24 Mar 2015||Brigham Young University||Carbon composite support structure|
|US8995621||15 Jul 2011||31 Mar 2015||Moxtek, Inc.||Compact X-ray source|
|US9072154||26 Sep 2013||30 Jun 2015||Moxtek, Inc.||Grid voltage generation for x-ray tube|
|US9076628||7 Nov 2012||7 Jul 2015||Brigham Young University||Variable radius taper x-ray window support structure|
|US9173623||9 Apr 2014||3 Nov 2015||Samuel Soonho Lee||X-ray tube and receiver inside mouth|
|US9174412||2 Nov 2012||3 Nov 2015||Brigham Young University||High strength carbon fiber composite wafers for microfabrication|
|US9177755||24 Jan 2014||3 Nov 2015||Moxtek, Inc.||Multi-target X-ray tube with stationary electron beam position|
|US9184020||24 Jan 2014||10 Nov 2015||Moxtek, Inc.||Tiltable or deflectable anode x-ray tube|
|US9305735||1 Feb 2011||5 Apr 2016||Brigham Young University||Reinforced polymer x-ray window|
|US20010009970 *||12 Feb 2001||26 Jul 2001||Medtronic Ave, Inc.||X-ray catheter|
|US20020146090 *||20 Nov 2001||10 Oct 2002||Chornenky Victor I.||Device for delivering localized x-ray radiation to an interior of a body and method of manufacture|
|US20040165699 *||21 Feb 2003||26 Aug 2004||Rusch Thomas W.||Anode assembly for an x-ray tube|
|US20050226378 *||6 Apr 2004||13 Oct 2005||Duke University||Devices and methods for targeting interior cancers with ionizing radiation|
|US20060171506 *||28 Feb 2004||3 Aug 2006||Lovoi Paul A||Miniature x-ray tube cooling system|
|US20060233307 *||18 Jun 2002||19 Oct 2006||Mark Dinsmore||X-ray source for materials analysis systems|
|US20060280291 *||25 Apr 2006||14 Dec 2006||Moxtek, Inc.||Radiation window and method of manufacture|
|US20070016179 *||20 Mar 2006||18 Jan 2007||Darius Francescatti||Radiation blocking patch for radio-therapy|
|US20070025516 *||30 Mar 2006||1 Feb 2007||Bard Erik C||Magnetic head for X-ray source|
|US20070076849 *||28 Sep 2006||5 Apr 2007||Moxtek,Inc||X-ray tube cathode with reduced unintended electrical field emission|
|US20080009658 *||19 Jun 2006||10 Jan 2008||Smith Peter C||Radiation therapy apparatus with selective shielding capability|
|US20080009659 *||19 Jun 2006||10 Jan 2008||Smith Peter C||Radiation therapy apparatus with selective shielding capability|
|US20080296518 *||1 Jun 2007||4 Dec 2008||Degao Xu||X-Ray Window with Grid Structure|
|US20090022277 *||18 Jul 2007||22 Jan 2009||Moxtek, Inc.||Cathode header optic for x-ray tube|
|US20090086923 *||26 Sep 2008||2 Apr 2009||Davis Robert C||X-ray radiation window with carbon nanotube frame|
|US20100200771 *||12 Aug 2010||Georgia Tech Research Corporation||Microirradiators and methods of making and using same|
|US20110188635 *||4 Aug 2011||Korea Advanced Institute Of Science And Technology||Super miniature x-ray tube using nano material field emitter|
|USRE41741||1 Mar 2004||21 Sep 2010||Carl Zeiss Ag||Optically driven therapeutic radiation source having a spiral shaped thermionic cathode|
|EP0847249A1 *||22 Aug 1996||17 Jun 1998||Interventional Innovations Corporation||X-ray catheter|
|WO1997007740A1||22 Aug 1996||6 Mar 1997||Interventional Innovations Corporation||X-ray catheter|
|WO2000074105A1 *||31 May 2000||7 Dec 2000||Siemens Aktiengesellschaft||X-ray tube and catheter having such an x-ray tube|
|WO2001058525A1 *||8 Feb 2001||16 Aug 2001||Photoelectron Corporation||Apparatus for local radiation therapy|
|WO2002041947A2 *||21 Nov 2001||30 May 2002||Sarnoff Corporation||Method and apparatus for delivering localized x-ray radiation to the interior of a body|
|WO2002041947A3 *||21 Nov 2001||31 Jul 2003||Sarnoff Corp||Method and apparatus for delivering localized x-ray radiation to the interior of a body|
|WO2005091810A3 *||10 Feb 2005||30 Nov 2006||Xoft Micro Tube Inc||Miniature x-ray tube cooling system|
|U.S. Classification||378/121, 378/65, 378/122|
|International Classification||A61N5/10, H01J35/00, H01J35/32|
|Cooperative Classification||H01J35/32, H01J35/00, H01J2235/087, A61N5/1001|
|European Classification||A61N5/10B, H01J35/00, H01J35/32|
|11 Feb 1999||AS||Assignment|
Owner name: PARKER,WILLIAM J., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PARKER MICRO-TUBES, INC.;REEL/FRAME:009748/0779
Effective date: 19981230
|3 Aug 1999||FPAY||Fee payment|
Year of fee payment: 8
|17 May 2000||AS||Assignment|
Owner name: X TECHNOLOGIES LTD., NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PARKER, WILLIAM J.;REEL/FRAME:010832/0641
Effective date: 20000504
|6 Mar 2003||AS||Assignment|
Owner name: GUIDANT CORPORATION, INDIANA
Free format text: SECURITY AGREEMENT;ASSIGNOR:X TECHNOLOGIES INC.;REEL/FRAME:013463/0799
Effective date: 20030304
|3 Sep 2003||FPAY||Fee payment|
Year of fee payment: 12
|3 Sep 2003||SULP||Surcharge for late payment|
Year of fee payment: 11