USRE32186E - Fluid transfer apparatus and method of fluid transfer - Google Patents

Fluid transfer apparatus and method of fluid transfer Download PDF

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Publication number
USRE32186E
USRE32186E US06/452,848 US45284882A USRE32186E US RE32186 E USRE32186 E US RE32186E US 45284882 A US45284882 A US 45284882A US RE32186 E USRE32186 E US RE32186E
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Prior art keywords
tubules
blood
dialyzer
inlet
outlet
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Expired - Lifetime
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US06/452,848
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Donald J. Bentley
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American Hospital Supply Corp
Baxter International Inc
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American Hospital Supply Corp
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Priority claimed from US06/004,486 external-priority patent/US4240907A/en
Application filed by American Hospital Supply Corp filed Critical American Hospital Supply Corp
Priority to US06/452,848 priority Critical patent/USRE32186E/en
Assigned to AMERICAN HOSPITAL SUPPLY CORPORATION ONE AMERICAN PLAZA, EVANSTON, ILLINOIS 60201 A CORP OF ILLINOIS reassignment AMERICAN HOSPITAL SUPPLY CORPORATION ONE AMERICAN PLAZA, EVANSTON, ILLINOIS 60201 A CORP OF ILLINOIS ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: AMERICAN BENTLEY INC., A CORP OF DE
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Publication of USRE32186E publication Critical patent/USRE32186E/en
Assigned to BAXTER TRAVENOL LABORATORIES, INC. A CORP. OF DE reassignment BAXTER TRAVENOL LABORATORIES, INC. A CORP. OF DE MERGER (SEE DOCUMENT FOR DETAILS). EFFECTIVE ON 11/25/1985 ILLINOIS Assignors: AMERICAN HOSPITAL SUPPLY CORPORATION INTO
Assigned to BAXTER INTERNATIONAL INC. reassignment BAXTER INTERNATIONAL INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). EFFECTIVE ON 10/17/1988 Assignors: BAXTER TRAVENOL LABORATORIES, INC., A CORP. OF DE
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/28—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/025—Bobbin units
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means

Definitions

  • the present invention relates to hollow fiber tubular kidney dialyzers.
  • Kidney dialyzers function to remove toxic substances from the blood of patients suffering from renal failure.
  • the dialyzers are fabricated with semipermeable membranes and dialysis is accomplished by flowing blood along one side of the membrane and a dialysate solution along the other side.
  • metabolites such as urea, uric acid, creatine, phosphorous and calcium in the blood diffuse from the blood to the dialysate solution through the membrane due to the lower concentration of metabolites in the dialysate solution.
  • Prior hollow fiber tubular kidney dialyzers comprised a bundle of several thousand individual microtubules, each consisting of a semipermeable material such as cellophane or Cuprophan®.
  • the tubules were positioned in a cylindrical container and supported in a generally parallel orientation between two support members disposed at each end of the container.
  • FIG. 4 illustrates this prior dialyzer tubule configuration.
  • the blood was circulated through the tubules and the dialysate solution was circulated through the container around the outside of the tubules. To maximize the efficiency of the dialyzer, a great number of tubules were positioned within the container.
  • tubules of the dialyzer expanded and contracted with changes in ambient temperature and humidity. The expansion of the tubules caused disruption of their original generally parallel orientation resulting in a more random and disordered positioning of the tubules. In this random orientation, there was even greater masking of the tubules which further reduced the efficiency of the dialyzer.
  • the random orientation of the tubules caused the bunching of tubules with the accompanying formation of localized areas of low flow of dialysate solution within the dialyzer thereby even further reducing the efficiency of the dialyzer.
  • An object of the present invention is to provide an improved dialyzer and method of operation. Other objects and advantages of this invention will become apparent on a reading of the entire specification, including the drawings and claims.
  • This invention provides an apparatus and method for blood dialysis wherein the efficiency of transfer across hollow fiber tubules is increased due to the tubule configuration.
  • the tubules are positioned in similarly curved configuration in order that they will all expand and contract in a uniform predetermined manner so as to prevent masking of adjacent tubules.
  • the tubules have a packing density of between about 20% and about 50%, and preferably between about 25% and about 35%. This increased packing density allows for more uniform distribution of the dialysate solution.
  • FIGS. 1 and 3 are partial cross-sectional views illustrating the device of this invention.
  • FIG. 2 is a pictorial view illustrating the device of this invention.
  • FIG. 4 is a schematic drawing illustrating a prior art device.
  • FIG. 5 is a schematic drawing illustrating the device of this invention.
  • FIG. 6 is a partial cross-sectional view illustrating the device of this invention.
  • FIG. 7 is a partial cross-sectional view illustrating the definition of the term "packing density" as used to describe the device of this invention.
  • the dialyzer 1 includes a dialyzer housing 3 disposed about a central core 5.
  • the core 5 has a dialysate inlet 7 and a dialysate outlet 9.
  • the dialysate inlet 7 and outlet 9 are provided with a plurality of apertures 11 and 13, respectively, positioned adjacent a point where the dialysate inlet and outlet about a cylindrical section 15 of the central core 5 which prevents the dialysate flow from passing through the cylindrical portion 15 of the central core 5 and forces the dialysate to flow outward through apertures 11 and into apertures 13 prior to exiting the dialyzer 1 at the dialysate outlet 9.
  • the dialyzer 1 is further defined as including a tangential blood inlet 17 and a tangential blood outlet 19.
  • a blood inlet chamber 21 is formed between the dialyzer cap 4, the exterior of the tubular dialysate inlet 7 and a suitable potting compound 23 within which a number of hollow fiber tubules 25 are secured.
  • the annular blood outlet chamber 27 is bounded by dialysate cap 6, the exterior of the tubular portion of the dialysate outlet 9 and potting compound 23 within which the tubules 25 are secured adjacent the blood outlet chamber 27.
  • a plurality of similarly curved and spirally oriented semipermeable hollow fiber tubules 25 are wrapped about the central core 5 such that Their opposed ends may be secured in an annular ring of potting compound 23.
  • the front and rear ends of the tubules 25 are preferably manufactured such that they have a rounded edge in order to prevent blood trauma upon entrance and exit from the dialyzer 1.
  • tubules 25 nearer the central core 5 are spiralled more than those more toward the outside of the wrap. This produces a nonparallel tubule relationship which increases flow shear as between adjacent layers of tubule wrap and promotes dialysate distribution and flow about the tubules 25 and transfer across the tubules.
  • Dialysate outlet apertures 11 are thus positioned between a front face 29 of the cylindrical portion 15 of the central core 5 and the annular ring of potting compound 23.
  • the dialysate outlet apertures 13 are positioned between a rear face 31 of the cylindrical portion 15 of the central core 5 and the annular ring of potting compound 23 located at the blood outlet of the tubules 25.
  • a compression means such as an inner flange 33 is positioned near the juncture of the dialysate inlet apertures 11 and the central core cylindrical portion 15 in order to increase the packing density of the tubules 25 in the area of the compression means.
  • the tubules 25 are separated from each other and having a packing density of between about 20% and about 50%, and preferably between about 25% and about 35%.
  • the packing density of the tubules at the flange means 33 is greater than that of the packing density of the balance of the tubules' length, and may be as high as 100%.
  • FIG. 7 shows a plurality of tubules 25 arranged in contiguous relationship such that each tubule is touching the other tubules adjacent it.
  • Such a configuration produces a number of voids designated as 50 in FIG. 7, due to the generally oval configuration of the tubules 25. If the tubules are compressed beyond the configuration of FIG. 7, the tubules will be deformed. Accordingly, the contiguous relationship illustrated in FIG. 7 is defined as illustrating a packing density of 100%.
  • the packing densities referred to in this disclosure are defined relative to the 100% packing density configuration shown in FIG. 7.
  • a plurality of tubules 25 are configured in a mat or belt 35 wherein the individual tubules 25 have fiber 37 interwoven within the tubules 25 in order to maintain their lateral spacing.
  • the belt or mat 35 is then wrapped about the central core 5 and a cylinder 39 having an external diameter approximately equal to that of the cylindrical portion 15 of the core 5.
  • the tubules may be held in place temporarily by means of an adhesive strip 33.
  • Member 39 is held in place about the tubular portion of the dialysate inlet by means of a keyway slot 41 which engages a key 43 along exterior of the tubular dialysate inlet 7.
  • a cap member (not shown) may then be placed about each end of the dialyzer 1 engaging the ends of the tubules 25.
  • a potting compound is then inserted into and about the area surrounding the tubules 25 between the cap member and the exterior of the tubular dialyzer inlet and outlet 7 and 9, respectively.
  • the potting compound consists of a liquid resin which sets upon exposure to air and/or heat.
  • the dialyzer assembly 1 is then rotated about its axis in order to urge the potting compound through centrifugal force to each end of the dialyzer assembly 1. After the potting compound is set up, the ends of the assembly are partially cut as shown by line 47 in order to produce the outward faces 49 and 51 of the annular rings of potting compound 23.
  • FIG. 4 shows a number of tubules secured at each end in the configuration typical of prior dialyzer applications.
  • the dotted lines indicate possible movement of the tubules upon expansion.
  • FIG. 5 illustrates movement due to expansion, again shown as dotted lines, of tubules which are arranged in a curved configuration.
  • each of the tubules expands in the same direction due to the fact that the tubules are predisposed to move in such a direction by means of the initial curvature of the tubules. While FIGS.
  • FIGS. 4 and 5 illustrate movement in two planes, it is to be understood that the spiral or helix configuration of the tubules 25 as shown in FIGS. 1 and 2 produce a three-dimensional predetermined configuration and allow for the tubules to move in expansion or contraction in a predetermined spaced apart relationship.

Abstract

An apparatus and method for blood dialysis. The device includes a plurality of semipermeable tubules for transporting blood therethrough. Distribution means are positioned adjacent the exterior of the tubules for admitting a dialysis solution which is passed along the outside of the tubules. The tubules are preferably arranged in a configuration such that the packing density of the tubules is between about 20% and about 50%, and preferably between about 25% and about 35%. This packing density insures adequate distribution of the dialysate solution as it is passed along the length of the tubules. The tubules may be wrapped and similarly curved; in a preferred embodiment they are spirally oriented. The configuration of the tubules allows for the movement of the tubule in a predetermined manner such that tubule masking is substantially prevented.

Description

RELATED APPLICATIONS
This application is a continuation of U.S. Patent application Ser. No. 813,455, filed July 7, 1977 which in turn is a continuation-in-part of U.S. Patent application Ser. No. 708,074, filed July 23, 1976, both now abandoned.
BACKGROUND OF THE INVENTION
The present invention relates to hollow fiber tubular kidney dialyzers.
Kidney dialyzers function to remove toxic substances from the blood of patients suffering from renal failure. The dialyzers are fabricated with semipermeable membranes and dialysis is accomplished by flowing blood along one side of the membrane and a dialysate solution along the other side. During the dialyzing process, metabolites such as urea, uric acid, creatine, phosphorous and calcium in the blood diffuse from the blood to the dialysate solution through the membrane due to the lower concentration of metabolites in the dialysate solution.
Prior hollow fiber tubular kidney dialyzers comprised a bundle of several thousand individual microtubules, each consisting of a semipermeable material such as cellophane or Cuprophan®. The tubules were positioned in a cylindrical container and supported in a generally parallel orientation between two support members disposed at each end of the container. FIG. 4 illustrates this prior dialyzer tubule configuration. The blood was circulated through the tubules and the dialysate solution was circulated through the container around the outside of the tubules. To maximize the efficiency of the dialyzer, a great number of tubules were positioned within the container. Unfortunately, the high packing density and the randomly parallel orientation of tubules forced many tubules to mask, or come into contact with other tubules, precluding dialysis through the contiguous surfaces and thereby reducing the efficiency of the dialyzer. Furthermore, the tubules of the dialyzer expanded and contracted with changes in ambient temperature and humidity. The expansion of the tubules caused disruption of their original generally parallel orientation resulting in a more random and disordered positioning of the tubules. In this random orientation, there was even greater masking of the tubules which further reduced the efficiency of the dialyzer. Further, during operation of the dialyzer, the random orientation of the tubules caused the bunching of tubules with the accompanying formation of localized areas of low flow of dialysate solution within the dialyzer thereby even further reducing the efficiency of the dialyzer.
An object of the present invention is to provide an improved dialyzer and method of operation. Other objects and advantages of this invention will become apparent on a reading of the entire specification, including the drawings and claims.
SUMMARY OF THE INVENTION
This invention provides an apparatus and method for blood dialysis wherein the efficiency of transfer across hollow fiber tubules is increased due to the tubule configuration. The tubules are positioned in similarly curved configuration in order that they will all expand and contract in a uniform predetermined manner so as to prevent masking of adjacent tubules. Further, the tubules have a packing density of between about 20% and about 50%, and preferably between about 25% and about 35%. This increased packing density allows for more uniform distribution of the dialysate solution.
DESCRIPTION OF THE DRAWINGS
FIGS. 1 and 3 are partial cross-sectional views illustrating the device of this invention.
FIG. 2 is a pictorial view illustrating the device of this invention.
FIG. 4 is a schematic drawing illustrating a prior art device.
FIG. 5 is a schematic drawing illustrating the device of this invention.
FIG. 6 is a partial cross-sectional view illustrating the device of this invention.
FIG. 7 is a partial cross-sectional view illustrating the definition of the term "packing density" as used to describe the device of this invention.
DESCRIPTION OF PREFERRED EMBODIMENTS
Referring now to FIG. 1, the dialyzer, generally referred to as 1, and its method of operation will be discussed. The dialyzer 1 includes a dialyzer housing 3 disposed about a central core 5. The core 5 has a dialysate inlet 7 and a dialysate outlet 9. The dialysate inlet 7 and outlet 9 are provided with a plurality of apertures 11 and 13, respectively, positioned adjacent a point where the dialysate inlet and outlet about a cylindrical section 15 of the central core 5 which prevents the dialysate flow from passing through the cylindrical portion 15 of the central core 5 and forces the dialysate to flow outward through apertures 11 and into apertures 13 prior to exiting the dialyzer 1 at the dialysate outlet 9.
The dialyzer 1 is further defined as including a tangential blood inlet 17 and a tangential blood outlet 19. A blood inlet chamber 21 is formed between the dialyzer cap 4, the exterior of the tubular dialysate inlet 7 and a suitable potting compound 23 within which a number of hollow fiber tubules 25 are secured. Similarly, the annular blood outlet chamber 27 is bounded by dialysate cap 6, the exterior of the tubular portion of the dialysate outlet 9 and potting compound 23 within which the tubules 25 are secured adjacent the blood outlet chamber 27.
As shown in FIG. 2, a plurality of similarly curved and spirally oriented semipermeable hollow fiber tubules 25 are wrapped about the central core 5 such that Their opposed ends may be secured in an annular ring of potting compound 23. The front and rear ends of the tubules 25 are preferably manufactured such that they have a rounded edge in order to prevent blood trauma upon entrance and exit from the dialyzer 1.
As the thickness of the annular ring of layers of tubules 25 increases as the wrapping continues, tubules 25 nearer the central core 5 are spiralled more than those more toward the outside of the wrap. This produces a nonparallel tubule relationship which increases flow shear as between adjacent layers of tubule wrap and promotes dialysate distribution and flow about the tubules 25 and transfer across the tubules.
Dialysate outlet apertures 11 are thus positioned between a front face 29 of the cylindrical portion 15 of the central core 5 and the annular ring of potting compound 23. Similarly, the dialysate outlet apertures 13 are positioned between a rear face 31 of the cylindrical portion 15 of the central core 5 and the annular ring of potting compound 23 located at the blood outlet of the tubules 25.
Preferably, a compression means such as an inner flange 33 is positioned near the juncture of the dialysate inlet apertures 11 and the central core cylindrical portion 15 in order to increase the packing density of the tubules 25 in the area of the compression means. The tubules 25 are separated from each other and having a packing density of between about 20% and about 50%, and preferably between about 25% and about 35%. The packing density of the tubules at the flange means 33 is greater than that of the packing density of the balance of the tubules' length, and may be as high as 100%.
Referring now to FIG. 7, the term "packing density" as utilized in this disclosure will be explained. FIG. 7 shows a plurality of tubules 25 arranged in contiguous relationship such that each tubule is touching the other tubules adjacent it. Such a configuration produces a number of voids designated as 50 in FIG. 7, due to the generally oval configuration of the tubules 25. If the tubules are compressed beyond the configuration of FIG. 7, the tubules will be deformed. Accordingly, the contiguous relationship illustrated in FIG. 7 is defined as illustrating a packing density of 100%. The packing densities referred to in this disclosure are defined relative to the 100% packing density configuration shown in FIG. 7.
Referring now to FIGS. 2 and 3, the method of making such a dialyzer will be discussed. A plurality of tubules 25 are configured in a mat or belt 35 wherein the individual tubules 25 have fiber 37 interwoven within the tubules 25 in order to maintain their lateral spacing. The belt or mat 35 is then wrapped about the central core 5 and a cylinder 39 having an external diameter approximately equal to that of the cylindrical portion 15 of the core 5. When the last layer of mat or belt 35 has been wrapped about the core 5, the tubules may be held in place temporarily by means of an adhesive strip 33. Member 39 is held in place about the tubular portion of the dialysate inlet by means of a keyway slot 41 which engages a key 43 along exterior of the tubular dialysate inlet 7. As shown in FIG. 3, a cap member (not shown) may then be placed about each end of the dialyzer 1 engaging the ends of the tubules 25. A potting compound is then inserted into and about the area surrounding the tubules 25 between the cap member and the exterior of the tubular dialyzer inlet and outlet 7 and 9, respectively. Preferably, the potting compound consists of a liquid resin which sets upon exposure to air and/or heat. The dialyzer assembly 1 is then rotated about its axis in order to urge the potting compound through centrifugal force to each end of the dialyzer assembly 1. After the potting compound is set up, the ends of the assembly are partially cut as shown by line 47 in order to produce the outward faces 49 and 51 of the annular rings of potting compound 23.
Referring now to FIGS. 4 and 5, the advantages of the curved configuration of the tubules 25 will be discussed in detail. FIG. 4 shows a number of tubules secured at each end in the configuration typical of prior dialyzer applications. The dotted lines indicate possible movement of the tubules upon expansion. In contrast, FIG. 5 illustrates movement due to expansion, again shown as dotted lines, of tubules which are arranged in a curved configuration. As may be seen in FIG. 5, each of the tubules expands in the same direction due to the fact that the tubules are predisposed to move in such a direction by means of the initial curvature of the tubules. While FIGS. 4 and 5 illustrate movement in two planes, it is to be understood that the spiral or helix configuration of the tubules 25 as shown in FIGS. 1 and 2 produce a three-dimensional predetermined configuration and allow for the tubules to move in expansion or contraction in a predetermined spaced apart relationship.
While an embodiment and application of this invention have been shown and described, it will be apparent to those skilled in the art that modifications are possible without departing from the inventive concepts described herein. This invention, therefore, is not to be restricted or limited save by the claims appended hereto.

Claims (4)

What is claimed is: .[.
1. A method of waste containing blood flow dialysis comprising:
tangentially admitting blood into a dialyzer blood inlet chamber;
passing said blood from said blood inlet chamber into and through a plurality of similarly spirally oriented semipermeable tubules packed between the dizlyzer housing and a central dialyzer core;
passing blood wastes through the walls of said tubules into said dialysate;
passing the treated blood from said tubules into a dialyzer blood outlet chamber;
longitudinally restraining said tubules between said dialyzer blood inlet chamber and said blood outlet chamber;
tangentially removing said treated blood from a dialyzer blood outlet chamber;
radially distributing a fresh dialysate about the exterior of said tubules;
passing in a generally spirally manner said dialysate along the exterior of said tubules; and
radially removing said dialysate and blood wastes from said dialyzer..]. .[.
2. The method claimed in claim 1 wherein said tubules are further defined as having a packing density of between about 20% and 50%..].
3. A .[.helical flow dialyzer.]. .Iadd.fluid transfer apparatus .Iaddend.comprising:
a .[.dialyzer.]. housing disposed about a central core, said core including a tubular .[.dialyzate.]. .Iadd.fluid .Iaddend.inlet and a tubular .[.dialyzate.]. .Iadd.fluid .Iaddend.outlet, both said .[.dialyzate.]. .Iadd.fluid .Iaddend.inlet and outlet being provided with a plurality of apertures and being joined by a cylindrical section of said central core for preventing .[.dialyzate.]. .Iadd.fluid .Iaddend.flow through said cylindrical portion and for forcing .[.dialyzate.]. .Iadd.fluid .Iaddend.inlet and outlet;
an annular blood inlet chamber and an annular blood outlet chamber formed within said .[.dialyzer.]. housing about said tubular .[.dialyzate.]. .Iadd.fluid .Iaddend.inlet and outlet, respectively, said inlet chamber having a tangential inlet nozzle and said outlet chamber having a tangential outlet nozzle;
a belt made up of similarly .[.helically.]. oriented semipermeable tubules, .[.wrapped about.]. .Iadd.surrounding .Iaddend.said central core, opposed ends of said tubule belt being secured in an annular ring of potting compound formed about a portion of said .[.dialyzate.]. .Iadd.fluid .Iaddend.inlet and outlet such that said .[.dialysate.]. .Iadd.fluid .Iaddend.inlet and outlet apertures are located within an enclosure formed by said .[.dialyzer.]. housing, said central core and said annular potting rings, said annular rings forming a portion of said blood inlet and blood outlet chambers, said ends of said hollow fibers passing through said annular rings for communication with said blood inlet and outlet chambers; and
a compression means positioned near the juncture of said .[.dialyzate.]. .Iadd.fluid .Iaddend.inlet and said central core cylindrical portion between said housing and said central core and about said tubules for increasing the packaging density of said tubules in the area adjacent said compression means.
4. The .[.helical flow dialyzer.]. .Iadd.fluid transfer apparatus .Iaddend.claimed in claim 3 wherein said tubules are further defined as having a packaging density of between about 20% and 50%.
US06/452,848 1976-07-23 1982-12-23 Fluid transfer apparatus and method of fluid transfer Expired - Lifetime USRE32186E (en)

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Application Number Priority Date Filing Date Title
US06/452,848 USRE32186E (en) 1976-07-23 1982-12-23 Fluid transfer apparatus and method of fluid transfer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70807476A 1976-07-23 1976-07-23
US81345577A 1977-07-07 1977-07-07
US06/004,486 US4240907A (en) 1976-07-23 1979-01-18 Dialyzer and method of dialysis
US06/452,848 USRE32186E (en) 1976-07-23 1982-12-23 Fluid transfer apparatus and method of fluid transfer

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US81345577A Continuation 1976-07-23 1977-07-07
US06/004,486 Reissue US4240907A (en) 1976-07-23 1979-01-18 Dialyzer and method of dialysis

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084244A (en) * 1989-01-10 1992-01-28 Terumo Kabushiki Kaisha Artificial lung assembly
US5489413A (en) * 1992-11-03 1996-02-06 Cobe Laboratories, Inc. Hollow fiber blood oxygenator
USRE36774E (en) 1989-10-01 2000-07-11 Baxter Healthcare Corporation Cylindrical blood heater/oxygenator

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3442002A (en) * 1965-12-22 1969-05-06 Du Pont Method of manufacture of fluid separation apparatus
GB1175124A (en) * 1966-11-16 1969-12-23 Rech S Tech Et Ind S R T I Soc Improvements in and relating to Dialysis Apparatus
US3536611A (en) * 1967-02-06 1970-10-27 Abcor Inc Membrane device and method
US3768653A (en) * 1972-03-21 1973-10-30 R Brumfield Filtering cardiotomy reservoir
SU523699A1 (en) * 1974-04-30 1976-08-05 Всесоюзный научно-исследовательский институт водоснабжения, канализации, гидротехнических сооружений и инженерной гидрогеологии Method of making apparatus with hollow semi-permeable fibers
US4141836A (en) * 1975-09-24 1979-02-27 Chemisch-pharmazeutische Industrie KG. Apparatebau Dr. Eduard Fresenius Dialyser cartridge and method for its manufacture
US4219426A (en) * 1976-03-19 1980-08-26 Organon Teknika B.V. Dialysis device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3442002A (en) * 1965-12-22 1969-05-06 Du Pont Method of manufacture of fluid separation apparatus
GB1175124A (en) * 1966-11-16 1969-12-23 Rech S Tech Et Ind S R T I Soc Improvements in and relating to Dialysis Apparatus
US3536611A (en) * 1967-02-06 1970-10-27 Abcor Inc Membrane device and method
US3768653A (en) * 1972-03-21 1973-10-30 R Brumfield Filtering cardiotomy reservoir
SU523699A1 (en) * 1974-04-30 1976-08-05 Всесоюзный научно-исследовательский институт водоснабжения, канализации, гидротехнических сооружений и инженерной гидрогеологии Method of making apparatus with hollow semi-permeable fibers
US4141836A (en) * 1975-09-24 1979-02-27 Chemisch-pharmazeutische Industrie KG. Apparatebau Dr. Eduard Fresenius Dialyser cartridge and method for its manufacture
US4219426A (en) * 1976-03-19 1980-08-26 Organon Teknika B.V. Dialysis device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084244A (en) * 1989-01-10 1992-01-28 Terumo Kabushiki Kaisha Artificial lung assembly
USRE36774E (en) 1989-10-01 2000-07-11 Baxter Healthcare Corporation Cylindrical blood heater/oxygenator
US5489413A (en) * 1992-11-03 1996-02-06 Cobe Laboratories, Inc. Hollow fiber blood oxygenator
US5733398A (en) 1992-11-03 1998-03-31 Cobe Laboratories, Inc. Efficient methods of manufacturing hollow fiber exchangers

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