US8715499B2 - Chromatography columns and their operation - Google Patents
Chromatography columns and their operation Download PDFInfo
- Publication number
- US8715499B2 US8715499B2 US12/558,665 US55866509A US8715499B2 US 8715499 B2 US8715499 B2 US 8715499B2 US 55866509 A US55866509 A US 55866509A US 8715499 B2 US8715499 B2 US 8715499B2
- Authority
- US
- United States
- Prior art keywords
- column tube
- column
- drive
- tube
- piston portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active, expires
Links
- 238000004587 chromatography analysis Methods 0.000 title claims abstract description 16
- 238000012423 maintenance Methods 0.000 claims abstract description 14
- 239000012501 chromatography medium Substances 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 abstract description 18
- 230000007246 mechanism Effects 0.000 description 9
- 125000006850 spacer group Chemical group 0.000 description 7
- 239000012530 fluid Substances 0.000 description 6
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 229920006351 engineering plastic Polymers 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 230000004323 axial length Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6021—Adjustable pistons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/603—Construction of the column end pieces retaining the stationary phase, e.g. Frits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6047—Construction of the column with supporting means; Holders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/52—Physical parameters
- G01N2030/522—Physical parameters pressure
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/558,665 US8715499B2 (en) | 2003-12-10 | 2009-09-14 | Chromatography columns and their operation |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0328674.7 | 2003-12-10 | ||
GBGB0328674.7A GB0328674D0 (en) | 2003-12-10 | 2003-12-10 | Chromatography columns and their operation |
PCT/GB2004/005184 WO2005056156A1 (en) | 2003-12-10 | 2004-12-10 | Chromatography columns and their operation |
US58196807A | 2007-02-26 | 2007-02-26 | |
US12/558,665 US8715499B2 (en) | 2003-12-10 | 2009-09-14 | Chromatography columns and their operation |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2004/005184 Division WO2005056156A1 (en) | 2003-12-10 | 2004-12-10 | Chromatography columns and their operation |
US10/581,968 Division US7604747B2 (en) | 2003-12-10 | 2004-12-10 | Chromatography columns and their operation |
US58196807A Division | 2003-12-10 | 2007-02-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
US20100000928A1 US20100000928A1 (en) | 2010-01-07 |
US8715499B2 true US8715499B2 (en) | 2014-05-06 |
Family
ID=30130000
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/581,968 Active 2025-04-07 US7604747B2 (en) | 2003-12-10 | 2004-12-10 | Chromatography columns and their operation |
US12/558,665 Active 2028-03-19 US8715499B2 (en) | 2003-12-10 | 2009-09-14 | Chromatography columns and their operation |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/581,968 Active 2025-04-07 US7604747B2 (en) | 2003-12-10 | 2004-12-10 | Chromatography columns and their operation |
Country Status (6)
Country | Link |
---|---|
US (2) | US7604747B2 (en) |
EP (1) | EP1691910B1 (en) |
JP (1) | JP5068077B2 (en) |
CA (1) | CA2547769A1 (en) |
GB (1) | GB0328674D0 (en) |
WO (1) | WO2005056156A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE523783T1 (en) * | 2004-09-07 | 2011-09-15 | Asahi Kasei Bioprocess Inc | COLUMN AND METHOD FOR LIFTING-FREE CHROMATOGRAPHY |
GB0507918D0 (en) | 2005-04-19 | 2005-05-25 | Novartis Ag | Organic compounds |
EP2094365A4 (en) | 2006-12-13 | 2010-09-01 | Bio Rad Laboratories | Supporting structures for preparative chromatography columns |
JP4862729B2 (en) * | 2007-03-30 | 2012-01-25 | 栗田工業株式会社 | Chromatographic column support pressure device and chromatography device |
US7785473B2 (en) * | 2007-06-15 | 2010-08-31 | Ge Healthcare Bio-Sciences Ab | Chromatography column and method of maintenance |
US7780853B2 (en) | 2007-06-15 | 2010-08-24 | Ge Healthcare Bio-Sciences Ab | Method for conducting maintenance on a chromatography column |
US7708891B2 (en) | 2007-06-15 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Chromatography column and method of maintenance |
JP4973507B2 (en) * | 2008-01-08 | 2012-07-11 | 栗田工業株式会社 | Chromatography apparatus and control apparatus for chromatography apparatus |
GB0801127D0 (en) * | 2008-01-22 | 2008-02-27 | Ge Healthcare Bio Sciences Ab | Method for removing air from a chromatography column |
GB0801212D0 (en) | 2008-01-23 | 2008-02-27 | Ge Healthcare Bio Sciences Ab | Chromatography column and maintenance method |
US8066876B2 (en) | 2009-11-23 | 2011-11-29 | Agilent Technologies, Inc. | Apparatus and methods for packing chromatography columns |
US8246833B2 (en) | 2009-12-17 | 2012-08-21 | Ge Healthcare Bio-Sciences Ab | Chromatography column and maintenance method |
JP5585170B2 (en) * | 2010-03-31 | 2014-09-10 | 栗田工業株式会社 | Chromatography column |
US20110259831A1 (en) * | 2010-04-22 | 2011-10-27 | Michael Brandt | Tracking regulator system and method for processing columns |
US8668829B2 (en) * | 2010-06-23 | 2014-03-11 | Ge Healthcare Bio-Sciences Ab | Method for performing maintenance on a chromatography column |
GB2485837A (en) * | 2010-11-29 | 2012-05-30 | Ge Healthcare Bio Sciences Ab | Securing a distributor plate of a chromatography column by generating a vacuum |
US8663477B2 (en) * | 2012-06-21 | 2014-03-04 | Ge Healthcare Bio-Sciences Ab | Chromatography column stand |
CN103505909B (en) * | 2012-06-21 | 2018-02-13 | 通用电气健康护理生物科学股份公司 | Chromatographic column framework and the method safeguarded and filled to chromatographic column |
JP6231088B2 (en) | 2012-06-21 | 2017-11-15 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | Adapter for chromatography columns |
US20150041381A1 (en) | 2013-08-07 | 2015-02-12 | Pall Corporation | Chromatography column |
DE202016000500U1 (en) * | 2016-01-26 | 2016-03-15 | Dr. Albin Maisch High Performance LC GmbH | LC column with permanent static-axial compression (SAC) |
US11745119B2 (en) | 2018-04-16 | 2023-09-05 | Asahi Kasei Bioprocess America, Inc. | Chromatography and synthesis column apparatus and method of assembly |
AU2022240588A1 (en) * | 2021-03-16 | 2023-10-26 | Bio-Rad Laboratories, Inc. | Dynamic axial compression for preparative columns using external compression |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4451365A (en) | 1981-10-30 | 1984-05-29 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Column clamping device for chromatography |
WO1996010451A1 (en) | 1994-10-03 | 1996-04-11 | Euroflow (Uk) Limited | Access valve devices, their use in separation apparatus, and corresponding methods |
WO1997032207A1 (en) | 1996-02-29 | 1997-09-04 | Varian Associates, Inc. | Collapsible apparatus for compressing packing material in liquid chromatography columns and methods of use |
US5674455A (en) | 1993-10-19 | 1997-10-07 | Labomatic Instruments | Axially compressible device for chromatography |
US5681474A (en) | 1994-09-06 | 1997-10-28 | Hoechst Aktiengesellschaft | Low-pressure chromatography column with automatically movable lid |
US5708191A (en) | 1996-04-05 | 1998-01-13 | Battelle Memorial Institute | Ultrasonic fluid densitometry and densitometer |
US5886250A (en) | 1996-04-05 | 1999-03-23 | Battelle Memorial Institute | Pitch-catch only ultrasonic fluid densitometer |
WO2000000259A1 (en) | 1998-06-30 | 2000-01-06 | Millipore Corporation | Chromatographic column |
WO2000033935A1 (en) | 1998-12-10 | 2000-06-15 | Millipore Corporation | Chromatography column system and method of packing of a chromatography column |
US6082180A (en) | 1998-10-21 | 2000-07-04 | Battelle Memorial Institute | Ultrasonic fluid densitometer for process control |
US6082181A (en) | 1998-10-21 | 2000-07-04 | Battelle Memorial Institute | Ultrasonic fluid densitometer having liquid/wedge and gas/wedge interfaces |
US6117317A (en) | 1997-05-23 | 2000-09-12 | Millipore Investment Holdings Limited | Chromatographic column and valve with movable valve sleeve |
US6190560B1 (en) | 1999-09-30 | 2001-02-20 | Mann Welding Company | Slurry fill method and valve |
WO2003076923A1 (en) | 2002-03-04 | 2003-09-18 | Millipore Corporation | Improved chromatography column |
US6736974B1 (en) | 2001-11-02 | 2004-05-18 | Mann Welding Company | Chromatography column and method of operation |
US6763698B2 (en) | 2002-03-15 | 2004-07-20 | Battelle Memorial Institute | Self calibrating system and technique for ultrasonic determination of fluid properties |
US6877375B2 (en) | 2002-05-06 | 2005-04-12 | Battelle Memorial Institute | System and technique for characterizing fluids using ultrasonic diffraction grating spectroscopy |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2248029A (en) * | 1990-09-19 | 1992-03-25 | Amicon Ltd | Chromatography system. |
EP0823971B1 (en) * | 1996-02-29 | 2004-07-14 | Varian, Inc. | Collapsible apparatus for compressing packing material in liquid chromatography columns and method of use |
FR2823134B1 (en) * | 2001-04-10 | 2003-09-19 | Novasep | CHROMATOGRAPHIC BED PROTECTION DEVICE IN CHROMATOGRAPHIC COLUMNS WITH DYNAMIC AXIAL COMPRESSION |
ATE523783T1 (en) * | 2004-09-07 | 2011-09-15 | Asahi Kasei Bioprocess Inc | COLUMN AND METHOD FOR LIFTING-FREE CHROMATOGRAPHY |
-
2003
- 2003-12-10 GB GBGB0328674.7A patent/GB0328674D0/en not_active Ceased
-
2004
- 2004-12-10 EP EP04806004.0A patent/EP1691910B1/en active Active
- 2004-12-10 JP JP2006543623A patent/JP5068077B2/en active Active
- 2004-12-10 US US10/581,968 patent/US7604747B2/en active Active
- 2004-12-10 CA CA002547769A patent/CA2547769A1/en not_active Abandoned
- 2004-12-10 WO PCT/GB2004/005184 patent/WO2005056156A1/en active Application Filing
-
2009
- 2009-09-14 US US12/558,665 patent/US8715499B2/en active Active
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4451365A (en) | 1981-10-30 | 1984-05-29 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Column clamping device for chromatography |
US5674455A (en) | 1993-10-19 | 1997-10-07 | Labomatic Instruments | Axially compressible device for chromatography |
US5681474A (en) | 1994-09-06 | 1997-10-28 | Hoechst Aktiengesellschaft | Low-pressure chromatography column with automatically movable lid |
WO1996010451A1 (en) | 1994-10-03 | 1996-04-11 | Euroflow (Uk) Limited | Access valve devices, their use in separation apparatus, and corresponding methods |
WO1997032207A1 (en) | 1996-02-29 | 1997-09-04 | Varian Associates, Inc. | Collapsible apparatus for compressing packing material in liquid chromatography columns and methods of use |
US5708191A (en) | 1996-04-05 | 1998-01-13 | Battelle Memorial Institute | Ultrasonic fluid densitometry and densitometer |
US5886250A (en) | 1996-04-05 | 1999-03-23 | Battelle Memorial Institute | Pitch-catch only ultrasonic fluid densitometer |
US6117317A (en) | 1997-05-23 | 2000-09-12 | Millipore Investment Holdings Limited | Chromatographic column and valve with movable valve sleeve |
WO2000000259A1 (en) | 1998-06-30 | 2000-01-06 | Millipore Corporation | Chromatographic column |
US6082180A (en) | 1998-10-21 | 2000-07-04 | Battelle Memorial Institute | Ultrasonic fluid densitometer for process control |
US6082181A (en) | 1998-10-21 | 2000-07-04 | Battelle Memorial Institute | Ultrasonic fluid densitometer having liquid/wedge and gas/wedge interfaces |
WO2000033935A1 (en) | 1998-12-10 | 2000-06-15 | Millipore Corporation | Chromatography column system and method of packing of a chromatography column |
US6190560B1 (en) | 1999-09-30 | 2001-02-20 | Mann Welding Company | Slurry fill method and valve |
US6558539B1 (en) | 1999-09-30 | 2003-05-06 | William H. Mann | Slurry fill method and valve |
US6736974B1 (en) | 2001-11-02 | 2004-05-18 | Mann Welding Company | Chromatography column and method of operation |
WO2003076923A1 (en) | 2002-03-04 | 2003-09-18 | Millipore Corporation | Improved chromatography column |
US6763698B2 (en) | 2002-03-15 | 2004-07-20 | Battelle Memorial Institute | Self calibrating system and technique for ultrasonic determination of fluid properties |
US6877375B2 (en) | 2002-05-06 | 2005-04-12 | Battelle Memorial Institute | System and technique for characterizing fluids using ultrasonic diffraction grating spectroscopy |
Non-Patent Citations (1)
Title |
---|
Greenwood, M. S. et al., Journal of Fluids Engineering, 126(2):189-192 (2004). |
Also Published As
Publication number | Publication date |
---|---|
WO2005056156A1 (en) | 2005-06-23 |
EP1691910B1 (en) | 2014-08-06 |
JP5068077B2 (en) | 2012-11-07 |
GB0328674D0 (en) | 2004-01-14 |
CA2547769A1 (en) | 2005-06-23 |
US7604747B2 (en) | 2009-10-20 |
US20100000928A1 (en) | 2010-01-07 |
EP1691910A1 (en) | 2006-08-23 |
US20070138098A1 (en) | 2007-06-21 |
JP2007515271A (en) | 2007-06-14 |
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Legal Events
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FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
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STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
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MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1551) Year of fee payment: 4 |
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AS | Assignment |
Owner name: PALL INTERNATIONAL SARL, SWITZERLAND Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PALL EUROPE LTD.;REEL/FRAME:051661/0161 Effective date: 20200128 Owner name: PALL EUROPE LTD., UNITED KINGDOM Free format text: DISSOLUTION AND TRANSFER OF ASSETS;ASSIGNOR:PALL EUROFLOW LTD.;REEL/FRAME:051737/0189 Effective date: 20140108 |
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AS | Assignment |
Owner name: SARTORIUS STEDIM CHROMATOGRAPHY SYSTEMS LTD., UNITED KINGDOM Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PALL INTERNATIONAL SARL;REEL/FRAME:052659/0140 Effective date: 20200430 |
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