|Publication number||US8690827 B2|
|Application number||US 12/818,496|
|Publication date||8 Apr 2014|
|Filing date||18 Jun 2010|
|Priority date||1 Feb 2005|
|Also published as||CA2594627A1, CA2594627C, CA2762072A1, CN101111281A, CN101111281B, EP1843812A2, EP1843812A4, EP2058020A2, EP2058020A3, EP2058020B1, US7749194, US8123719, US8172082, US8544645, US8920367, US9724471, US20070129708, US20080103490, US20080306436, US20100318035, US20120116318, US20120280815, US20150011973, US20150174323, WO2006083876A2, WO2006083876A3|
|Publication number||12818496, 818496, US 8690827 B2, US 8690827B2, US-B2-8690827, US8690827 B2, US8690827B2|
|Inventors||Evan T. Edwards, Eric S. Edwards, Mark J. Licata|
|Original Assignee||Kaleo, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (376), Non-Patent Citations (63), Referenced by (12), Classifications (27), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a continuation of U.S. patent application Ser. No. 10/572,148, entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Mar. 16, 2006, now U.S. Pat. No. 7,749,194 which is a national stage filing under 35 U.S.C. §371 of International Patent Application No. PCT/US06/03415, entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Feb. 1, 2006, which claims priority to U.S. Provisional Application Ser. No. 60/648,822 entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Feb. 1, 2005, and U.S. Provisional Application Ser. No. 60/731,886, entitled “Devices, Systems, and Methods for Medicament Delivery,” filed Oct. 31, 2005, each of which is incorporated herein by reference in its entirety.
A wide variety of potential embodiments will be more readily understood through the following detailed description of certain exemplary embodiments, with reference to the accompanying exemplary drawings in which:
When the following terms are used substantively herein, the accompanying definitions apply:
a—at least one.
activate—to actuate and/or set in motion and/or action.
activity—an action, act, step, and/or process or portion thereof.
actuating portion—that part that puts something into action.
actuation lock—a device adapted to prevent actuation, such as, for example a pivotable, translatable, keyed, squeezable, and/or removable lock.
actuator—a mechanism that puts something into action.
adapted to—suitable or fit for a particular purpose.
and/or—either in conjunction with or in alternative to.
apparatus—a mechanism and/or device.
arm—an elongated structural member, which need not be solely linear.
auto-injector—device that allows a user to deliver a medicament without having to manually prepare the injection. Exemplary devices include pen delivered injectors, syringes, needleless injectors, gas powered auto-injectors, and/or any other auto-injector and/or medical device used to inject a medicament into a user/patient, etc.
automatically—acting or operating in a manner essentially independent of external influence or control. For example, an automatic light switch can turn on upon “seeing” a person in its view, without the person manually operating the light switch.
axis—a straight line about which a body or geometric object rotates or may be conceived to rotate.
can—is capable of, in at least some embodiments.
channel—a conduit for one or more fluids.
compressed gas—a substantially pressurized substance, such as helium, nitrogen, and/or carbon dioxide, etc., in a gaseous form.
comprising—including but not limited to.
contain—to hold within.
contents—a contained compressed gas.
credit card—a card (usually plastic) that assures a seller that the person using it has a satisfactory credit rating and that the issuer will see to it that the seller receives payment for the merchandise and/or services delivered. Typically measuring in size from approximately 3 to approximately 4 inches in length, such as approximately 3.40 inches, 3.375 inches, 85 millimeters, etc., and from approximately 1.75 to approximately 2.75 inches in width, such as approximately 2.10 inches, 2.2125 inches, 2.5 inches, 55 millimeters, etc.
data—distinct pieces of information, usually formatted in a special or predetermined way and/or organized to express concepts.
define—to establish the outline, form, or structure of.
device—a machine, manufacture, and/or collection thereof.
discharge—to release from confinement; to emit.
driving force—a force sufficient to cause, directly or indirectly, expulsion of an injectable medicament from one or more vials and/or from an auto-injector.
dry substance—a material that is substantially free from liquid or moisture.
embedded system—a programmed hardware device comprising a microprocessor controlled by an operating system and/or control logic that is specifically designed for a particular kind of application. The operating system and/or control logic of an embedded system comprises a limited set of pre-defined functions that can not be modified or added to by additional user-installed software, although some embedded systems allow a user to modify values of variables and/or parameters of the pre-defined functions. Exemplary devices that can comprise embedded systems are: medical devices, calculators, automobiles, airplanes, vending machines, toys, programmable logic controllers, appliances, refrigerators, microwave ovens, clothes washers, thermostats, alarm systems, sprinkler systems, lighting controllers, electronic equipment, laser printers, CD players, DVD players, watches, and/or digital cameras, etc.
escape port—an opening for the exit of a gas.
expulsion—the act of forcibly ejecting a fluid via a designed outlet of a container.
expulsion pressure—a force applied over an area of a liquid, the force sufficient to expel the liquid in a predetermined manner.
extend—to move out and/or away from.
extendable—able to move out and/or away from.
fluid—a gas and/or liquid.
fluidly coupleable—able to be related via a fluid.
force initiator—a source, such as a compressed gas container, spring, and/or chemical reaction, etc., capable of supplying a driving force.
frangible—a device that is capable of being broken and/or penetrated to allow fluid to flow therethrough.
haptic—involving the human sense of kinesthetic movement and/or the human sense of touch. Among the many potential haptic experiences are numerous sensations, body-positional differences in sensations, and time-based changes in sensations that are perceived at least partially in non-visual, non-audible, and non-olfactory manners, including the experiences of tactile touch (being touched), active touch, grasping, pressure, friction, traction, slip, stretch, force, torque, impact, puncture, vibration, motion, acceleration, jerk, pulse, orientation, limb position, gravity, texture, gap, recess, viscosity, pain, itch, moisture, temperature, thermal conductivity, and thermal capacity.
hard real-time—relating to computer systems that provide an absolute deterministic response to an event. Such a response is not based on average event time. Instead, in such computer systems, the deadlines are fixed and the system must guarantee a response within a fixed and well-defined time. Systems operating in hard real-time typically interact at a low level with physical hardware via embedded systems, and can suffer a critical failure if time constraints are violated. A classic example of a hard real-time computing system is the anti-lock brakes on a car. The hard real-time constraint, or deadline, in this system is the time in which the brakes must be released to prevent the wheel from locking. Another example is a car engine control system, in which a delayed control signal might cause engine failure or damage. Other examples of hard real-time embedded systems include medical systems such as heart pacemakers and industrial process controllers.
hazardous condition—a situation marked by risk, danger, and/or peril.
housing—something that covers, encloses, protects, holds, and/or supports.
in reaction to—responding indirectly and/or directly to.
indicate—to show, mark, signify, denote, evidence, evince, manifest, declare, enunciate, specify, explain, exhibit, present, reveal, disclose, and/or display.
indicator—a device and/or substance that indicates.
information device—any device capable of processing information, such as any general purpose and/or special purpose computer, such as a personal computer, workstation, server, minicomputer, mainframe, supercomputer, computer terminal, laptop, wearable computer, and/or Personal Digital Assistant (PDA), mobile terminal, Bluetooth device, communicator, “smart” phone (such as a Treo-like device), messaging service (e.g., Blackberry) receiver, pager, facsimile, cellular telephone, a traditional telephone, telephonic device, a programmed microprocessor or microcontroller and/or peripheral integrated circuit elements, an ASIC or other integrated circuit, a hardware electronic logic circuit such as a discrete element circuit, and/or a programmable logic device such as a PLD, PLA, FPGA, or PAL, or the like, etc. In general any device on which resides a finite state machine capable of implementing at least a portion of a method, structure, and/or or graphical user interface described herein may be used as an information device. An information device can comprise components such as one or more network interfaces, one or more processors, one or more memories containing instructions, and/or one or more input/output (I/O) devices, one or more user interfaces coupled to an I/O device, etc.
injectable medicament—a medicine, medication, drug, pharmaceutical, prescriptive, agent, antidote, anti-venom, hormone, stimulant, vasodilator, anesthetic, and/or nutritional supplement that is substantially ready for injection.
input/output (I/O) device—any sensory-oriented input and/or output device, such as an audio, visual, haptic, olfactory, and/or taste-oriented device, including, for example, a monitor, display, projector, overhead display, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, microphone, speaker, video camera, camera, scanner, printer, haptic device, vibrator, tactile simulator, and/or tactile pad, potentially including a port to which an I/O device can be attached or connected.
liquid—a body of matter that exhibits a characteristic readiness to flow, little or no tendency to disperse, and relatively high incompressibility.
longitudinal—of or relating to longitude or length.
machine instructions—directions adapted to cause a machine, such as an information device, to perform a particular operation or function.
machine readable medium—a physical structure from which a machine can obtain data and/or information. Examples include a memory, punch cards, etc.
may—is allowed to, in at least some embodiments.
memory device—an apparatus capable of storing analog or digital information, such as instructions and/or data. Examples include a nonvolatile memory, volatile memory, Random Access Memory, RAM, Read Only Memory, ROM, flash memory, magnetic media, a hard disk, a floppy disk, a magnetic tape, an optical media, an optical disk, a compact disk, a CD, a digital versatile disk, a DVD, and/or a raid array, etc. The memory device can be coupled to a processor and/or can store instructions adapted to be executed by processor, such as according to an embodiment disclosed herein.
method—a process, procedure, and/or collection of related activities for accomplishing something.
microprocessor—an integrated circuit comprising a central processing unit.
mixable—dissolvable, dispersible, and/or capable of being put into so that the dry substance is diffused and/or commingled in the liquid.
needle—a hollow, slender, sharp-pointed instrument used for injection. Includes cannulas.
network—a communicatively coupled plurality of nodes.
network interface—any device, system, or subsystem capable of coupling an information device to a network. For example, a network interface can be a telephone, cellular phone, cellular modem, telephone data modem, fax modem, wireless transceiver, ethernet card, cable modem, digital subscriber line interface, bridge, hub, router, or other similar device.
non-co-axial—not having co-linear axes.
output device—an apparatus configured to visually, audibly, and/or haptically render information to a human. Examples include an audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), a visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), and a haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), etc.
patient—a receiver of an injectable medicament, such as a human, mammal, animal, etc.
piston—a sliding piece which either is moved by, or moves against, fluid pressure.
pivotable—capable of pivoting.
plurality—the state of being plural and/or more than one.
predetermined—established in advance.
processor—a device and/or set of machine-readable instructions for performing one or more predetermined tasks. A processor can comprise any one or a combination of hardware, firmware, and/or software. A processor can utilize mechanical, pneumatic, hydraulic, electrical, magnetic, optical, informational, chemical, and/or biological principles, signals, and/or inputs to perform the task(s). In certain embodiments, a processor can act upon information by manipulating, analyzing, modifying, converting, transmitting the information for use by an executable procedure and/or an information device, and/or routing the information to an output device. A processor can function as a central processing unit, local controller, remote controller, parallel controller, and/or distributed controller, etc. Unless stated otherwise, the processor can be a general-purpose device, such as a microcontroller and/or a microprocessor, such the Pentium IV series of microprocessor manufactured by the Intel Corporation of Santa Clara, Calif. In certain embodiments, the processor can be dedicated purpose device, such as an Application Specific Integrated Circuit (ASIC) or a Field Programmable Gate Array (FPGA) that has been designed to implement in its hardware and/or firmware at least a part of an embodiment disclosed herein.
programmable logic controller (PLC)—a solid-state, microprocessor-based, hard real-time computing system that is used, via a network, to automatically monitor the status of field-connected sensor inputs, and automatically control communicatively-coupled devices of a controlled system (e.g., actuators, solenoids, relays, switches, motor starters, speed drives (e.g., variable frequency drives, silicon-controlled rectifiers, etc.), pilot lights, ignitors, speakers, tape drives, printers, monitors, displays, etc.) according to a user-created set of values and user-created logic and/or instructions stored in memory. The sensor inputs reflect measurements and/or status information related to the controlled system. A PLC provides any of: automated input/output control; switching; counting; arithmetic operations; complex data manipulation; logic; timing; sequencing; communication; data file manipulation; report generation; control; relay control; motion control; process control; distributed control; and/or monitoring of processes, equipment, and/or other automation of the controlled system. Because of its precise and hard real-time timing and sequencing capabilities, a PLC is programmed using ladder logic or some form of structured programming language specified in IEC 61131-3, namely, FBD (Function Block Diagram), LD (Ladder Diagram), ST (Structured Text, Pascal type language), IL (Instruction List) and/or SFC (Sequential Function Chart). Because of its precise and real-time timing and sequencing capabilities, a PLC can replace up to thousands of relays and cam timers. PLC hardware often has good redundancy and fail-over capabilities. A PLC can use a Human-Machine Interface (HMI) for interacting with users for configuration, alarm reporting, and/or control.
puncturer—a device adapted to penetrate using a substantially sharp and/or tapered point, tip, edge, or the like.
pusher—a device adapted to convert fluid pressure to mechanical movement.
render—make perceptible to a human, for example as data, commands, text, graphics, audio, video, animation, and/or hyperlinks, etc., such as via any visual, audio, and/or haptic means, such as via a display, monitor, electric paper, ocular implant, cochlear implant, speaker, etc.
repeatedly—again and again; repetitively.
reservoir—a receptacle or chamber for storing and/or directing movement of a fluid.
resist—to avoid and/or remain firm against the actions, effects, and/or force of.
retract—to pull inward.
safety tab—a removable device configured to prevent actuation of an auto-injector when the safety tab is in one orientation, and allow actuation when in another orientation.
sensed variable—a measured parameter.
set—a related plurality.
sheath—a protective cover.
shield—a protective device or structure.
soft real-time—relating to computer systems that take a best efforts approach and minimize latency from event to response as much as possible while keeping throughput up with external events overall. Such systems will not suffer a critical failure if time constraints are violated. For example, live audio-video systems are usually soft real-time; violation of time constraints can result in degraded quality, but the system can continue to operate. Another example is a network server, which is a system for which fast response is desired but for which there is no deadline. If the network server is highly loaded, its response time may slow with no failure in service. This is contrasted with the anti-lock braking system where a slow down in response would likely cause system failure, possibly even catastrophic failure.
spring—an elastic device, such as a coil of wire, that regains its original shape after being compressed or extended.
status—a state or condition.
store—to place, hold, and/or retain data, typically in a memory.
substantially—to a great extent or degree.
system—a collection of mechanisms, devices, data, and/or instructions, the collection designed to perform one or more specific functions.
tip—a terminal end.
transfer—to convey from one place to another.
translatable—capable of being transferred from one place to another and/or of being moved with respect to something else.
triggerable—capable of being actuated.
use indication—information regarding a use of an auto-injector, such as information regarding any of auto-injector selection; auto-injector maintenance; auto-injector expiration; auto-injector replacement; medicament expiration; medicament selection; medicament mixing; injection delay; safety guard removal; auto-injector positioning; auto-injector orientation; actuator location; injection hazard avoidance; auto-injector actuation; injection duration; injection status; injection error; auto-injector removal; auto-injector reuse; auto-injector recycling; and auto-injector disposal, etc.
user input—human-provided information.
user interface—any device for rendering information to a user and/or requesting information from the user. A user interface includes at least one of textual, graphical, audio, video, animation, and/or haptic elements. A textual element can be provided, for example, by a printer, monitor, display, projector, etc. A graphical element can be provided, for example, via a monitor, display, projector, and/or visual indication device, such as a light, flag, beacon, etc. An audio element can be provided, for example, via a speaker, microphone, and/or other sound generating and/or receiving device. A video element or animation element can be provided, for example, via a monitor, display, projector, and/or other visual device. A haptic element can be provided, for example, via a very low frequency speaker, vibrator, tactile stimulator, tactile pad, simulator, keyboard, keypad, mouse, trackball, joystick, gamepad, wheel, touchpad, touch panel, pointing device, and/or other haptic device, etc. A user interface can include one or more textual elements such as, for example, one or more letters, number, symbols, etc. A user interface can include one or more graphical elements such as, for example, an image, photograph, drawing, icon, window, title bar, panel, sheet, tab, drawer, matrix, table, form, calendar, outline view, frame, dialog box, static text, text box, list, pick list, pop-up list, pull-down list, menu, tool bar, dock, check box, radio button, hyperlink, browser, button, control, palette, preview panel, color wheel, dial, slider, scroll bar, cursor, status bar, stepper, and/or progress indicator, etc. A textual and/or graphical element can be used for selecting, programming, adjusting, changing, specifying, etc. an appearance, background color, background style, border style, border thickness, foreground color, font, font style, font size, alignment, line spacing, indent, maximum data length, validation, query, cursor type, pointer type, autosizing, position, and/or dimension, etc. A user interface can include one or more audio elements such as, for example, a volume control, pitch control, speed control, voice selector, and/or one or more elements for controlling audio play, speed, pause, fast forward, reverse, etc. A user interface can include one or more video elements such as, for example, elements controlling video play, speed, pause, fast forward, reverse, zoom-in, zoom-out, rotate, and/or tilt, etc. A user interface can include one or more animation elements such as, for example, elements controlling animation play, pause, fast forward, reverse, zoom-in, zoom-out, rotate, tilt, color, intensity, speed, frequency, appearance, etc. A user interface can include one or more haptic elements such as, for example, elements utilizing tactile stimulus, force, pressure, vibration, motion, displacement, temperature, etc.
valve—a device that regulates flow through a pipe and/or through an aperture by opening, closing, and/or obstructing a port and/or passageway.
vent—to release from confinement.
via—by way of and/or utilizing.
vial—a closable vessel.
Exposure, such as via ingestion, inhalation, and/or injection, to certain allergens, toxins, and/or other substances can cause profound reactions for some and/or all people and/or animals. For example, certain people are highly allergic to certain substances, such as peanuts, shellfish, particular drugs, certain proteins, bee venom, insect bites, etc. The allergic response to the exposure can lead to anaphylactic shock, which can cause a sharp drop in blood pressure, hives, and/or substantial breathing difficulties caused by severe airway constriction. As another example, inhalation of certain nerve agents can cause severe physiological trauma. Responding rapidly to such exposures can prevent injury and/or death. For example, in response to an exposure leading to anaphylactic shock, an injection of epinephrine (i.e., adrenaline) can provide substantial and/or complete relief from the reaction. As another example, injection of an antidote to a nerve agent can greatly reduce and/or eliminate the potential harm of the exposure. As yet another example, rapid injection of certain drugs, such as a beta blocker, blood thinner, nitroglycerine, antihistamines, insulin, and opioids, etc., can provide substantial relief from various dangerous medical conditions.
Thus, certain exemplary embodiments provide systems, devices, and/or methods for rapidly injecting a medicament.
Certain exemplary embodiments comprise an apparatus, comprising: a compressed gas container; a plurality of vials adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to an actuating portion of a contents of the gas container; and a plurality of pistons, each piston adapted to move within a corresponding vial from the plurality of vials, the plurality of pistons adapted to, in response to discharge of the actuating portion of the contents of the compressed gas container, transfer at least a portion of the liquid medicament from the plurality of vials and through a needle that is extendable into a patient. Certain exemplary embodiments comprise a method comprising a plurality of activities, comprising: discharging an actuating portion of a contents of a compressed gas container, the compressed gas container contained within an apparatus; in reaction to said discharging activity, moving a piston within a vial, the vial one of a plurality of vials contained within the apparatus, each vial adapted to store a liquid medicament, each vial defining a longitudinal axis, the longitudinal axes of the plurality of vials parallel and non-co-axial, the plurality of vials fluidly coupleable to a contents of the gas container; and transferring a liquid medicament from the vial and through a needle that is extendable into a patient.
A status of a system 1000 can be determined via status indicator 1400, which can provide a view, such as via a UV blocking, photo-sensitive, and/or translucent window, into an interior of housing 1100. Viewable through the window can be a status of medicament carried by housing 1100, a location of a needle and/or injection apparatus for the medicament, and/or an activation status of system 1000. For example, if the medicament has aged to the point of discoloration, which aging might or might not render the medication useless, harmful, etc., status indicator 1400 can allow that situation to be determined. In certain exemplary embodiments, gas can escape housing 1100 via status indicator 1400 and/or another opening in housing 1100.
Certain exemplary embodiments of system 1000 can provide a compact medicament delivery mechanism that can efficiently and/or rapidly deliver a prescribed dose. The length (L) and width (W) of system 1000 can be similar to that of a credit card, and the thickness (T) can be less than one inch. Thus, certain exemplary embodiments of system 1000 can provide a conveniently carried, easy-to-use, easy to activate drug delivery apparatus that can require little to no training to safely carry, use, and/or dispose of.
To assist a user in positioning system 1000 in a correct orientation for injection, system 1000 and/or housing 1100 can provide various tactile clues. For example, a top 1110 of housing 1100 can be rounded, and a bottom 1120 of actuation bar 1300 of housing 1100 can be flat. Other tactile clues are also possible, such as bulges, ribs, grooves, gaps, roughened surfaces, indentations, etc.
System 1000 can comprise a housing 1100, handheld portion 1800, actuation guard 1200, and/or actuation bar 1300. System 1000 can comprise system actuator 2000, gas reservoirs 3000, medicament actuator 4000, medicament storage assembly 5000, medicament carrier 9000, needle assembly 6000, use indicator 7000, and/or gas vent mechanism 8000, etc.
Upon removal, release, rotation, and/or relocation of actuation guard 1200, system actuator 2000 can be adapted to rapidly discharge an actuating portion of a contents of a compress gas container. For example, system actuator 2000 can comprise a compressed gas container 2400, which initially can contain a compressed gas 2500, an actuating portion of which can be released from container 2400 by penetration of a gas port 2600 via a point of a puncturer 2700. Upon removal and/or relocation of actuation guard 1200, actuation bar 1300 can be moved closer to and/or in contact with handheld portion 1800. Upon removal and/or relocation of actuation guard 1200, gas container 2400 can be brought into contact with puncturer 2700 via extension of a pre-compressed spring 2300 and/or movement of a actuation stick 2200. Thus, actuation guard 1200 can prevent accident activation of system 1000 and/or unintended discharge of an actuating portion of the contents 2500 of gas container 2400.
Once gas port 2600 has been punctured, an actuating portion of compressed gas 2500 can escape from container 2400 and flow via gas reservoirs 3000, such as gas channel 3100. The flowing gas can meet and/or apply gas pressure to medicament actuator 4000, which can comprise a pusher 4100, which can travel within a sleeve 1500 defined by walls 1520. Sleeve 1500 can be constructed of metal, stainless steel, aluminum, plastic, polycarbonate, etc. Seals 4200, such as o-rings, can resist gas leakage, such as past pusher 4100 and/or out of housing 1100. Thus, pusher 4100 can function as a piston traveling within a cylinder, although it is not necessarily required that the cross-sectional shape of sleeve 1500 be round.
Medicament actuator 4000 can interface with medicament storage assembly 5000. For example, medicament actuator 4000 can comprise a plurality of plungers 4300, each of which can be capped with a piston 4400 which can sealingly slide and/or move within a corresponding vial 5100 containing a liquid medicament 5200. For example, in response to pressure applied by an actuating portion of the contents 2500 of compressed gas container 2400, pusher 4100 can cause plungers 4300 and/or pistons 4400 to simultaneously move. The number of corresponding sets of plungers 4300, pistons 4400, and/or vials 5100 can be 2, 3, 4, 5, 6, or more. Pistons 4400 can be constructed of a resilient, durable, and/or sealing material, such as a rubber. Each plunger 4300 from the plurality of plungers can define a longitudinal axis, the longitudinal axes (e.g., axes 4310, 4320, 4330, 4340) of the plurality of plungers parallel, non-coaxial, and/or co-planar.
Each vial 5100 from the plurality of vials can be substantially cylindrical with a substantially round and/or substantially elliptical cross-sectional shape. Thus, each vial 5100 can define a longitudinal axis, the longitudinal axes of the plurality of vials parallel, non-coaxial, and/or co-planar. The longitudinal axis of each vial can be co-axial with the longitudinal axis of its corresponding plunger.
Each vial can be capped at one end with a frangible 5300, which can be burst when piston 4400 generates sufficient pressure upon medicament 5200, thereby allowing at least a portion of medicament 5200 to flow out of vial 5100 and into medicament carrier 9000. Thus, the plurality of vials can be fluidly coupleable to the actuating portion of the contents 2500 of gas container 2400.
Medicament carrier 9000 can hold each of vials 5100 and can travel within sleeve 1500. Medicament carrier 9000 can comprise a plurality of channels 9200 adapted to receive medicament 5200 as it exits its respective vial 5100, and direct medicament 5200 to a common conduit 9300. Medicament carrier 9000 can interface with needle assembly 6000 and/or use indicator 7000.
From common conduit 9300, medicament 5200 can enter needle assembly 6000, such as into a single needle 6100 via which medicament can approach needle tip 6200. As medicament actuator 4000 and/or medicament carrier 9000 are driven toward actuator bar 1300, needle tip 6200 can penetrate an end 6400 of needle sheath 6300 and exit actuator bar 1300 at needle port 1340.
As medicament carrier stop 9400 contacts actuator bar stop 1300, medicament carrier hooks 9600 can engage with engagement receivers 7100 in use indicator 7000.
As medicament carrier 9000 moves away from actuator bar 1300, needle 6100 can retract into sheath 6300 which un-buckles and/or un-deforms towards its original shape. Eventually, needle 6100 can retract completely within the boundaries of housing 1100, thereby tending to prevent accidental needle sticks after the initial injection and/or potentially reducing and/or eliminating a sharps hazard.
In certain exemplary embodiments, system actuator 2000 can comprise a finger triggered, twistable, pivotable, and/or lever-operated mechanism. For example, system actuator 2000 can comprise a twistable handle that can screw into gas port 2600. In certain exemplary embodiments, system actuator 2000 can be a finger trigger located on a side of the housing.
As pistons 4440 near the limit of their travels, engagement of gas release actuator 9700 with gas release valve 8200 can cause compressed spring 8300 to move valve arm such that o-ring 8400 is urged away from its seat 8500. This movement can reveal a passage 8600, via which gas can exit gas chamber 3200 along gas exhaust path 8900, which can extend between sleeve inner walls 1520 and outer walls 9100 of medicament carrier 9000. Eventually, gas exhaust path 8900 can extend between handheld portion 1800 and actuator bar 1300. Likewise, an alternative embodiment of valve 8200, made of rubber or any other resilient material, can be placed across seat 8500 to provide a seal that, once gas release actuator 9700 interacts with valve 8200, allows valve 8200 to bend or flap upwards away from seat 8500, causing the gas to escape via passage 8600.
The following paragraphs expands on the above and describe various exemplary embodiments relating to compact auto-injectors that can comprise and/or utilize a vial or a plurality of vials to store and/or contain an injectable medicament. These auto-injectors can have a compact form factor, such as approximately the size of a credit card. There are many methods of delivering such medicaments in such compact devices. The below descriptions cover multiple methods and/or mechanisms that can effectively administer a medicament using a compact auto-injector.
Exemplary Embodiment One: Methods of Utilizing an Auto-Injector
This exemplary embodiment describes a method of implementing an auto-injector utilizing a spring and/or gas driven system to administer a medicament and/or comprises a needle protection system.
An embodiment for delivering medicament from a chamber can comprise a vial or plurality of vials; said chamber in communication with a needle that can be concealed initially by some shield and/or sheath; extending said needle from the sheath at least 1 mm and/or inserting the needle past a needle insertion point to an injection site at a depth of at least 5 mm; the application of a force that can originate from the contents of a gas cylinder and/or by means of a spring or multiple springs sufficient to eject medicament held within said chamber into the needle and/or through the needle insertion point to a depth of at least 5 mm to deliver up to 5 ml of medicament into the injection site in less than 5 seconds; wherein the medicament can be injected and/or held through the use of a vial system that comprises a plunger, vial(s), reservoir, and/or needle that can be located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), reservoir, and/or needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site; wherein the needle can have a length of at least 6 mm and/or the medicament can be ejected at a pressure of at least 25 p.s.i. at a rate of at least 0.20 ml/sec; and/or wherein the needle can retract into the shield and/or housing and/or a needle protection portion slides over the needle following delivery of the medicament.
Exemplary Embodiment Two: Chemical Reaction
This exemplary embodiment involves an auto-injection system that utilizes a chemical reaction as an activation mechanism to deliver the medicament into a patient. It also comprises a needle protection system.
This exemplary embodiment comprises a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle can be protected by some sheath/shield; a chemical reaction capable of occurring when one chemical is allowed to interact with another chemical and/or a substance that may create such a reaction through the use of some activation mechanism; and said chemical reaction that can generate a force that is strong enough to drive said plunger, vial, reservoir, and needle towards the distal end of the housing; the needle exiting said sheath/shield and entering an injection site; the plunger(s) slideable in the vial(s) that contain the medicament; and said medicament exiting the vials into through the reservoir and needle cannula into the injection site; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
Exemplary Embodiment Three: The Spring Driven Injector
Certain exemplary embodiments of the auto-injector can use a spring or multiple springs to inject the medicament into a patient. The novelty of this system can lie in the orientation of the activation springs and the vial system (that comprises the plunger, vial(s), reservoir and the needle/cannula) system. Because the activation springs can be located in parallel to the vial system, the device can be smaller than existing devices on the market (that are linear in nature), potentially having a form factor that is approximately the size of a credit card.
Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament and/or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that contains a single needle or needle cannula at the distal end; the needle protected by some sheath/shield; the housing further comprising at least one spring (this can comprise a gas spring, coil spring, leaf spring, etc.) wherein the spring(s) is parallel to the plunger, vial(s), and reservoir system and is in communication with a solid member (that can be made of rubber, plastic, metal, and/or some other resilient material) that is also in communication with the proximal end of the plunger such that when the spring(s) is activated, a force is applied on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; the solid member is displaced away from the plunger, which can allow for the retraction of the entire needle, reservoir, vial(s), and plunger assembly towards proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or for a needle protection portion to slide over the needle following delivery of the medicament.
Exemplary Embodiment Four: Pulley System
This exemplary embodiment can utilize a pulley system as the activation mechanism for injecting medicament into the patient and that can also comprise a needle protection system.
Certain exemplary embodiments can comprise a delivery system that can encompass a housing, vial or plurality of vials, plunger for each vial, single needle or needle cannula, and medicament or medicaments within the vial or plurality of vials; the vial or plurality of vials in communication with the plunger(s) at proximal end and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle that can be protected by some sheath/shield; the housing further comprising one or more spring pulley system(s) that can constitute a spring connected to some slideable resilient material such as a string, wire, wire coil, flat metallic band, etc. at the proximal end of the housing, and said material that can travel through a channel in the housing from the proximal end of the housing towards the distal end of the housing and then returning through a parallel channel towards the proximal end wherein this material is connected to a solid member (made of rubber, plastic, metal, and/or some other resilient material); the solid member in communication with the proximal end of the plunger such that when the spring is activated the spring can produce enough force to allow the pulley system to operate by having the resilient material, such as a cord, which can forcefully travel towards the proximal end of the housing and can cause the cord to move the solid member in communication with the plunger, vial(s), reservoir, and/or needle towards the distal end; wherein the needle can exit said sheath/shield and can enter an injection site; the plunger(s) slideable in the vial(s) that can contain the medicament; and said medicament can exit the vials into through the reservoir and/or needle cannula into the injection site; upon exit of the desired contents of the vial, the solid member can be displaced away from the plunger allowing for the entire needle, reservoir, vial(s), and/or plunger assembly to retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion to slide over the needle following delivery of the medicament.
A pulley system is shown in
Exemplary Embodiment Five: The Needleless Injector
This exemplary embodiment can comprise a Needleless Injector that can be gas and/or spring activated and that can allow for a user to inject a medicament into a patient without the use of a needle. The use of a plurality of vials can be considered the novel component and can allow the device to be compact in nature, such as having the approximate length and width similar to that of a credit card.
Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber in communication with a passage into a small injection opening; the application of a force that can originate from the contents of a gas cylinder and/or by means of at least one spring that can eject medicament held within said chamber into the passage to the small injection opening, which can be defined and/or created by the housing and/or a small sterile rod that can be a needle or cannula allowing for the slight puncturing of the injection site in order to allow the medicament to be delivered, and through the tip of this small injection opening to a depth of at least 1 mm, that can deliver up to 5 ml of medicament into the injection site; wherein the medicament can be injected and held through the use of a vial system that comprises a plunger, vial(s), and/or reservoir all located within said chamber; wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial(s), and/or reservoir to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered through the reservoir into the small injection opening; wherein the injection opening point can be located more superficial than the injection site; wherein the medicament can be ejected at a pressure of at least 25 p.s.i. (For example, in such embodiments, the pressure to deliver a dose of 0.5 cc's could be about 100 pounds of force).
Exemplary Embodiment Six: The Multi-Pharmaceutical Injector
This exemplary embodiment can comprise a compact auto-injector that can incorporate a plurality of vials, allowing for multiple medicaments to be injected at one time or at different times. The use of a plurality of vials can be considered the novel component and also can have the advantage of creating a device that is compact in nature, such as one having the length and width of a credit card. The device also can comprise a needle protection system.
Certain exemplary embodiments for delivering medicament from a chamber can comprise a plurality of vials; the said chamber or chambers in communication with a needle or needles that can be concealed initially by shields and/or sheaths; that can extend said needle from the said sheath at least 1 mm and can insert the needle past a needle insertion point to an injection site at a depth of at least 5 mm; the application of a force and/or forces that can originate from the contents of a gas cylinder and/or multiple gas cylinders, and/or by means of a spring and/or springs sufficient to eject medicament held within said chamber into the needle and through the needle insertion point; wherein the medicament can be injected and held through the use of a vial system and/or vial systems that can comprise a plunger, vial, reservoir, and/or needle all located within said chamber(s); wherein the force can be applied on the plunger at the proximal end allowing for the plunger, vial, reservoir, and/or needle to travel towards the distal end of the housing; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; wherein the needle insertion point can be located more superficial than the injection site. The device potentially having a multitude of said components (including but not limited to vials, plungers, gas cylinders, springs, needles, reservoirs, sheaths, shields, chambers, and/or retracting springs) in order to administer multiple medicaments into a patient at one time and/or at different times, as one dose and/or in multiple doses, depending on when each individual system is activated. The device can have selectors and/or other mechanisms to allow the user to choose which medicament to administer. Each individual system can comprise an activation mechanism (such as a spring and/or gas cylinder), a chamber within said housing, and a plunger, vial, reservoir, needle, and/or retraction spring; wherein upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly retracts towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
A method for administering multiple pharmaceuticals is depicted in
Exemplary Embodiment Seven: The Wet/Dry Injector
This exemplary embodiment can comprise a compact auto-injector that can have the ability to mix two or more medicaments in either a liquid or powder form to create one injectable medicament. The novel component of this device can be considered to be the use of a plurality of vials to deliver the medicament. The device also can comprise a needle protection system.
An exemplary delivery system can comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, single needle or needle cannula, and/or a medicament or medicaments stored within each vial. Pre-injection, two or more medicaments can be stored separately in a vial and/or storage compartment and can communicate with each other once the mixing activation mechanism is initialized. The mixing activation mechanism could comprise a button, trigger, threaded rod, and or some other member that removes a piece or portion and/or punctures a piece or portion that is preventing each medicament to communicate with each other. The mixing activation mechanism may comprise a membrane, piece, and/or portion that may be removed pre-injection by the user in order to allow the separate vials and/or storage containers to communicate with each other. The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to cause the contents of each compartment to mix with each other. This communication may occur by shaking the device and/or may occur automatically with the mixing activation mechanism. For instance, the mixing activation mechanism may cause each medicament to be released into an activation chamber, which may itself be a separate vial. This mixed medicament can be the medicament that will be injected into the patient. The delivery system further encompassing the mixed medicament vial or plurality of mixed medicament vials in communication with the plunger(s) at the proximal end of the housing and in communication with a reservoir that can contain a single needle or needle cannula at the distal end; the needle can be protected by some sheath/shield; the housing can further comprise a passage that is also in communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing; wherein the force provided can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism; wherein the plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered; upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
Exemplary Embodiment Eight: Needle-End Safety System
Certain exemplary embodiments can comprise a safety system that can allow a user to remove some cap, bar, lock at the same end of an auto-injector housing where the needle is located. This can allow the device to be ready for activation while still protecting the needle at the same time. Many auto-injectors, such as most pen-like injectors, have the activation safety mechanism on the opposite end of where the needle is located. In an emergency situation, the user may mistake this safety cap as protecting the needle, when in fact this is not the case. There have been many documented cases of digital injection into a user's thumb or finger because of this reason. Having the safety mechanism at the same end of the needle can eliminate this risk.
Exemplary Embodiment Nine: Auto-Injector with Feedback
The use of auto-injectors and drug delivery systems is common in the medical industry. Auto-injectors can deliver a range of medicaments into a patient, ranging from chronic therapies to critical care injectables. As more therapies are developed, the need for a vehicle to deliver these therapies is ever-increasing. Certain auto-injectors currently on the market can lack attributes that can allow the user to understand the device's functionality and/or operation. Thus, there is perceived a need for an auto-injector that can provide audible, haptic, and/or visual feedback to the user in order to effectively train and/or guide the user on how to properly operate the auto-injector and/or to mitigate user-related hazards that could occur when the device is not used correctly.
The incidence of use-related hazards associated with auto-injectors is increasing. Common problems associated with certain injectors on the market include poor design, sharps exposure, and poor instruction. Many auto-injectors on the market are in the form of an apparatus that resembles a pen or marker. The safety mechanism for most of these devices can cause patient confusion as it is often protecting the activation mechanism and not the location where the needle protrudes out of the device. There have been numerous cases of the user accidentally injecting the needle into their own thumb or finger because of this hazard. Examples of devices that incorporate this design can include certain pen-type auto-injectors for allergic emergencies, and/or certain anti-nerve agent auto-injectors currently supplied to both domestic and foreign militaries. These devices, and most auto-injectors on the market, also can allow the needle to remain protruding out after use, thereby potentially causing a post-injection sharps hazard. Further, many of these injectors exhibit poor instruction and/or labeling. Due to the cylindrical design of certain auto-injectors, the surface area for labeling can be small, rounded, and therefore can prevent a user from easily reading important information regarding the use of the device. For many injectors that are used in emergency situations, it can be important that the user be able to use the device correctly and efficiently. The user might not take or have time to read the instructions on the device during such a critical scenario.
For one or more of these reasons, an interactive auto-injector or medical device is described that can provide a user with visual, haptic, and/or audible feedback in order to mitigate the aforementioned risks and/or to allow for easy injection of medications.
Certain exemplary embodiments can provide an interactive auto-injector and/or a method of providing audible, haptic, and/or visual feedback to a user when operating the auto-injector. An auto-injector can be defined as any device that allows a user to deliver a medicament without having to manually prepare the injection. This can include pen delivered injectors, syringes, needleless injectors, gas powered auto-injectors, and/or any other auto-injector and/or medical device used to inject a pharmaceutical into a user/patient, etc.
Certain exemplary embodiments can provide an auto-injector that can comprise an information device and/or system comprising at least one sensor (e.g., a pressure sensor, proximity sensor, tactile sensor, and/or biometric input device, etc.), switch (e.g., gate switch, microswitch, and/or pushbutton, etc.), embedded system (e.g., microprocessor, memory, embedded operating system, system bus, input/output interface, and/or network interface, etc.), audible output sub-system (e.g., speaker, horn, buzzer, and/or piezoelectric transducer, etc.), visual output sub-system (e.g., flag, marker, light, liquid crystal display (LCD), light emitting diode (LED), optical fiber, organic polymer display, electric paper, screen, display, monitor, and/or tube, etc.), haptic output sub-system (e.g., buzzer, vibrator, bulging portion, tactile stimulator, cooler, and/or heater, etc.), and/or any other component and/or sub-system that would aid in providing audible, visual, and/or haptic feedback to a user of the auto-injector, along with appropriate circuitry, control system(s), housing(s), shielding, electrical conductors, and/or power source(s), etc.
Certain embodiments of auto-injectors can comprise a housing, safety mechanism, activation mechanism (such as a spring means or compressed gas cylinder), a vial or container for storing the medicament, and a needle for delivering the medicament. Certain exemplary embodiments can provide one or more audible, visual, and/or haptic outputs to guide and/or instruct the user how to use the auto-injector properly. Sensors and/or switches can be placed on the safety tab, on the bottom of the device where the needle comes out, and/or where the inner sleeve slides up to activate the device. Visual outputs can be placed at each of the aforementioned locations as well and/or instead. An audible output sub-system can be placed anywhere on the device for audible feedback. A haptic output sub-system can be placed anywhere on the device. These electronically-triggered and/or active components and/or sub-systems can be incorporated into the labeling of the device and/or as a separate component to provide this visual, haptic, and/or audible feedback.
For example, the user can push a button or switch on the device to initiate the audible, haptic, and/or visual output sub-system. A pre-recorded audible voice can tell the user to pull up on the safety tab, while a visual and/or haptic output can be rendered on the safety tab to provide a visual and/or haptic clue to the user as to where the safety tab is located. Once the safety tab is pulled up correctly, a sensor or switch could trigger the next step for the voice to announce, for example, asking the user to place the base of the device on the outer portion of their thigh while also triggering a visual output to light the base of the device. By way of further example, the user can be provided a visual clue in which at least a portion of the base of the device is lighted and/or colored red, and/or the user can be provided a haptic clue in which the base on the device is moved and/or the base is heated sufficiently (such as to between approximately 105 degrees F. and approximately 120 degrees F., including all values and sub-ranges therebetween) to substantially warm, yet not burn, the user's skin. The embedded operating system, which can run in hard real-time to avoid delays that might be significant and/or life-threatening, can also recognize a failure to complete a step in a certain specific timeframe and cause the step to be repeated if necessary and/or provide negative feedback if the user fails to perform a step properly (e.g., via input from a sensor or switch, the operating system can timely notice that the device is not placed on the skin of the thigh correctly and can cause the audible output subsystem to tell the user to repeat the placement step). Once the user places the device on the thigh properly, the sensor or switch could trigger the next audible, visual, and/or haptic clue and/or output, such as asking the user to push down on the outside sleeve of the device with force. By instructing the user step-by-step through each task, user error and/or risks of certain hazards can be reduced and/or eliminated.
Certain exemplary embodiments can provide a compact, credit card-sized auto-injector used to deliver a variety of medicaments, such as pharmaceuticals and/or agents. Though this auto-injector can eliminate many problems associated with certain pen-style auto-injectors, such as the sharps hazard and/or the poor safety tab design, there can be a need for an interactive auto-injector in order to aid in user instruction of the device and/or to help ensure the device is used properly any and/or every time it is needed. The following, and the attached figures, further describes such an auto-injector.
For example, an audible output sub-system located in the housing can provide audible feedback to the user of the device. The audible output sub-system can be comprised of one or more piezoelectric transducers, small and/or large cones and/or speakers, sensors, capacitors, memories, power sources (e.g., battery, fuel cell, spring-actuated generator, etc.) housing, wires, and any other electronic components needed to provide recorded audible feedback to a user. The audible output sub-system can be activated by the aforementioned button or switch on the housing. The speaker can provide instructions for how the device is used and/or certain medication requirements.
As another example, visual outputs can be located throughout the device, and/or on the base, safety tab, labeling, and/or housing to provide visual clues to the user. These visual outputs can be activated by the operating system once a sensor or switch is triggered. An LCD, optical polymer, LED, electric paper, and/or other form of display, monitor, and/or screen and/or other visual output can provide data to the user such as dosage amount, expiration date, instructions, Federal Drug Administration (FDA) requirements, and/or other labeling requirements, etc.
Certain exemplary embodiments can comprise a compact auto-injector that can have the ability to mix two or more medicaments, agents, solutes, solvents, etc., in either a liquid or powder form and/or create one injectable medicament. Certain exemplary embodiments can include an interactive system that can provide haptic, audible, and/or visual feedback to provide the user with instructions, hints, and/or clues in order to use the device properly. The auto-injector also can comprise a needle protection system.
An exemplary delivery system can comprise a housing, plurality of vials, plunger for each vial, a mixing activation mechanism, an activation chamber or vial, single needle or needle cannula, and/or a medicament or medicaments stored within each vial, etc. Prior to injection, two or more medicaments can be stored separately in a vial and/or storage compartment and can fluidically communicate with each other once the mixing activation mechanism is initialized. The mixing activation mechanism can comprise a button, trigger, threaded rod, and or some other member that removes a piece or portion and/or punctures a piece or portion that is preventing each medicament from communicating with each other. The mixing activation mechanism can comprise a membrane, piece, and/or portion that can be removed pre-injection by the user in order to allow the separate vials and/or storage containers to fluidically communicate with each other. The mixing activation mechanism can be a piece that is manipulated in some way by the user in order to cause the contents of each compartment to mix with each other. This communication can occur by shaking the device and/or can occur automatically with the mixing activation mechanism. For instance, the mixing activation mechanism can cause each medicament to be released into an activation chamber, which may itself can be a separate vial. This mixed medicament can be the medicament that will be injected into the patient.
The delivery system can comprise the mixed medicament vial or plurality of mixed medicament vials in mechanical and/or fluid communication with the plunger(s) at the proximal end of the housing and in mechanical and/or fluid communication with a reservoir that can contain a single needle or needle cannula at the distal end. The needle can be protected by a sheath and/or shield. The housing can comprise a passage that is also in mechanical and/or fluid communication with the proximal end of the plunger such that when the spring(s) is activated from the distal or proximal end, a force can be applied through the passage on the plunger at the proximal end allowing for the plunger(s), vial(s), reservoir, and/or needle to travel towards the distal end of the housing. The applied force can be caused by a spring, bar, contents from a gas cylinder, and/or other force mechanism. The plunger can slideably travel through the vial towards the distal end to allow for the appropriate dose of medicament to be delivered. Upon exit of the desired contents of the vial, the entire needle, reservoir, vial, and/or plunger assembly can retract towards the proximal end of housing by some means such as a wire, spring, o-ring, and/or rubber membrane and/or a needle protection portion slides over the needle following delivery of the medicament.
The interactive system can comprise a speaker sub-system that can comprise piezos and/or other components to produce audible sounds and/or human voice; a haptic sub-system that can provide haptic feedback to the user; a visual sub-system that can comprise light emitting diodes, LCD's, optical fibers, and/or other components that can produce visual outputs such as light and/or color; a processor that can be used to control the activation of such components; a power source such as a battery that can power the aforementioned interactive system; and/or switches, buttons, and/or sensors that can activate certain visual, haptic, and/or audible clues at a particular moment.
The device can include an electronic/interactive system to provide visual, haptic, and/or audible feedback to the user. This interactive system can include a microprocessor to control the specific feedback components, a speaker subsystem, a haptic sub-system, a sub-system of switches and/or sensors, a subsystem of LEDs or optics, a battery power source, and any other component needed to produce audible or visual outputs.
In certain exemplary embodiments, via one or more user interfaces 26600, such as a graphical user interface, a user can view a rendering of information related to selecting, purchasing, obtaining, operating, maintaining, re-using, and/or disposing of an auto-injector. In certain exemplary embodiments, instructions 26400 can be modified and/or updated via replacing a removable memory 26300 and/or via replacing instructions 26400 (such as, e.g., via flashing an EEPROM, etc.). In certain exemplary embodiments, instructions 26400 can be modified and/or updated via downloading replacement instructions via network interface 26100. System 26000 can comprise a programmable logic controller.
Still other practical and useful embodiments will become readily apparent to those skilled in this art from reading the above-recited detailed description and drawings of certain exemplary embodiments. It should be understood that numerous variations, modifications, and additional embodiments are possible, and accordingly, all such variations, modifications, and embodiments are to be regarded as being within the spirit and scope of this application.
Thus, regardless of the content of any portion (e.g., title, field, background, summary, abstract, drawing figure, etc.) of this application, unless clearly specified to the contrary, such as via an explicit definition, assertion, or argument, with respect to any claim, whether of this application and/or any claim of any application claiming priority hereto, and whether originally presented or otherwise:
there is no requirement for the inclusion of any particular described or illustrated characteristic, function, activity, or element, any particular sequence of activities, or any particular interrelationship of elements;
any elements can be integrated, segregated, and/or duplicated;
any activity can be repeated, performed by multiple entities, and/or performed in multiple jurisdictions; and
any activity or element can be specifically excluded, the sequence of activities can vary, and/or the interrelationship of elements can vary.
Accordingly, the descriptions and drawings are to be regarded as illustrative in nature, and not as restrictive. Moreover, when any number or range is described herein, unless clearly stated otherwise, that number or range is approximate. When any range is described herein, unless clearly stated otherwise, that range includes all values therein and all subranges therein. Any information in any material (e.g., a United States patent, United States patent application, book, article, etc.) that has been incorporated by reference herein, is only incorporated by reference to the extent that no conflict exists between such information and the other statements and drawings set forth herein. In the event of such conflict, including a conflict that would render invalid any claim herein or seeking priority hereto, then any such conflicting information in such incorporated by reference material is specifically not incorporated by reference herein.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2960087||16 Feb 1954||15 Nov 1960||Auguste Rooseboom||Hypodermic injection apparatus|
|US3055362||16 May 1956||25 Sep 1962||Auguste Rooseboom||Hypodermic injection apparatus|
|US3115133||15 May 1962||24 Dec 1963||Donald Morando Emilio||Needleless prefilled disposable hypodermic injector|
|US3426448||2 Feb 1967||11 Feb 1969||Sarnoff Stanley J||Training injection device|
|US3688765||3 Oct 1969||5 Sep 1972||Gasaway Jack S||Hypodermic injection device|
|US3768472||7 Feb 1972||30 Oct 1973||Cometta C||Fluid dispensing gun|
|US3795061||21 Mar 1973||5 Mar 1974||Survival Technology||Training injector|
|US3945379||8 Aug 1974||23 Mar 1976||Smithkline Corporation||Injection device|
|US4108177||13 Apr 1977||22 Aug 1978||Michel Louis Paul Pistor||Automatic injector device|
|US4226235||25 Jan 1979||7 Oct 1980||Survival Technology, Inc.||Plural injecting device|
|US4360019||31 Mar 1980||23 Nov 1982||Andros Incorporated||Implantable infusion device|
|US4424057||1 Apr 1982||3 Jan 1984||House Hugh A||Wet-dry syringe|
|US4441629||10 Aug 1982||10 Apr 1984||Mackal Glenn H||Compressed gas powered caulking gun|
|US4484910||21 Dec 1983||27 Nov 1984||Survival Technology, Inc.||Dual mode automatic injector|
|US4573976||24 May 1984||4 Mar 1986||Dolores A. Smith||Shielded needle|
|US4596556||25 Mar 1985||24 Jun 1986||Bioject, Inc.||Hypodermic injection apparatus|
|US4610666||24 Jun 1985||9 Sep 1986||Pizzino Joanne L||Dual syringe|
|US4613328||22 Oct 1984||23 Sep 1986||Cecil Boyd||Bio-medical injector apparatus|
|US4617557||8 Nov 1984||14 Oct 1986||National Patent Development Corporation||Medication compliance aid for unit dose packaging|
|US4624660||1 Oct 1985||25 Nov 1986||Duphar International Research B.V.||Automatic injection device|
|US4640686||24 Feb 1986||3 Feb 1987||Survival Technology, Inc.||Audible signal autoinjector training device|
|US4643721||15 Nov 1985||17 Feb 1987||Poutrait-Morin||Multiple compartment ampule for automatic hypodermic syringes|
|US4666430||5 Dec 1984||19 May 1987||I-Flow Corporation||Infusion pump|
|US4673657||1 Jun 1984||16 Jun 1987||The Regents Of The University Of California||Multiple assay card and system|
|US4689042||20 May 1985||25 Aug 1987||Survival Technology, Inc.||Automatic medicament ingredient mixing and injecting apparatus|
|US4693708||16 Oct 1986||15 Sep 1987||Wanderer Alan A||Combination needle shield/needle guard device for a hypodermic syringe with a permanently attached needle|
|US4781697||4 Dec 1987||1 Nov 1988||Robert Slaughter||Removable protective shield for needle sheath|
|US4782841||30 Nov 1987||8 Nov 1988||Icu Medical, Inc.||Medical device|
|US4784652||12 Aug 1987||15 Nov 1988||Fagersta El & Diesel Ab||Eyewash dispenser|
|US4795433 *||31 Mar 1988||3 Jan 1989||Survival Technology, Inc.||Automatic injector for emergency treatment|
|US4853521||28 Dec 1987||1 Aug 1989||Claeys Ronald W||System for verifying and recording drug administration to a patient|
|US4865582||17 Mar 1988||12 Sep 1989||Drug Delivery Systems Inc.||Disposable transdermal drug applicators|
|US4874382||15 Oct 1987||17 Oct 1989||Servetus Partnership||Safety syringe|
|US4894054||20 Jun 1988||16 Jan 1990||Miskinyar Shir A||Preloaded automatic disposable syringe|
|US4906235||17 Oct 1988||6 Mar 1990||Roberts Christopher W||Needle guard|
|US4915695||12 Sep 1988||10 Apr 1990||Koobs David C||Multiple barrel syringe|
|US4941880||12 Dec 1988||17 Jul 1990||Bioject, Inc.||Pre-filled ampule and non-invasive hypodermic injection device assembly|
|US4959056||14 Jun 1988||25 Sep 1990||Wayne State University||Digital dispenser|
|US4968302||24 Jun 1987||6 Nov 1990||Eberhardt Schluter||Automatic injection device, including an ampoule or a cartridge for an injection device|
|US4983164||12 Apr 1988||8 Jan 1991||Astra Meditec Ab||Automatic two-chamber injector|
|US5000736||22 Mar 1990||19 Mar 1991||Harry Kaufhold, Jr.||Disposable syringe with automatic needle retraction|
|US5024656||30 Aug 1988||18 Jun 1991||Injet Medical Products, Inc.||Gas-pressure-regulated needleless injection system|
|US5037306||10 Oct 1990||6 Aug 1991||Duphar International Research B.V.||Training device for an automatic injector|
|US5038023||28 Jun 1989||6 Aug 1991||C. Itoh Information Systems Development, Inc.||System for storing and monitoring bar coded articles such as keys in a drawer|
|US5041088||21 Aug 1989||20 Aug 1991||Medimech International Ltd.||Multiple chamber automatic injector|
|US5062603||25 Apr 1990||5 Nov 1991||Dow Brands Inc.||Vacuum drum purge method and apparatus|
|US5064413||9 Nov 1989||12 Nov 1991||Bioject, Inc.||Needleless hypodermic injection device|
|US5071353||10 Oct 1990||10 Dec 1991||Duphar International Research B.V.||Training device for an automatic injector|
|US5085642||17 Jul 1989||4 Feb 1992||Survival Technology, Inc.||Conveniently carried frequent use autoinjector|
|US5092843||12 Apr 1990||3 Mar 1992||Survival Technology, Inc.||Dispersion multichamber auto-injector|
|US5125898||15 Oct 1991||30 Jun 1992||Harry Kaufhold, Jr.||Disposable syringe with automatic needle retraction|
|US5167641||29 May 1991||1 Dec 1992||Arnis, Inc.||Auto-retracting needle injector system|
|US5199949||21 Jun 1991||6 Apr 1993||Habley Medical Technology Corp.||Multiple pharmaceutical syringe|
|US5224936||15 Oct 1992||6 Jul 1993||Brian Gallagher||Automatic self-protecting hypodermic needle assembly|
|US5240146||17 Dec 1991||31 Aug 1993||Smedley William H||Variable proportion dispenser|
|US5281198||4 May 1992||25 Jan 1994||Habley Medical Technology Corporation||Pharmaceutical component-mixing delivery assembly|
|US5286258||8 Mar 1991||15 Feb 1994||Habley Medical Technology Corporation||Multipharmaceutical delivery system|
|US5298023||22 Sep 1992||29 Mar 1994||Habley Medical Technology Corporation||Multiple pharmaceutical dispenser with accumulator|
|US5312326||2 Jun 1992||17 May 1994||Alza Corporation||Iontophoretic drug delivery apparatus|
|US5314412||16 May 1991||24 May 1994||Novo Nordisk A S||Manifold for a two barrel syringe|
|US5314502||2 Oct 1992||24 May 1994||Alza Corporation||Iontophoretic delivery device|
|US5343519||7 Sep 1993||30 Aug 1994||Peter Feldman||Autodialer with pin feature|
|US5344407||4 May 1993||6 Sep 1994||Ryan Dana W||Safety holder for pre-filled disposable syringe cartridge|
|US5354284||9 Jun 1992||11 Oct 1994||Habley Medical Technology Corporation||Multiple injection syringe system|
|US5356376||8 Mar 1991||18 Oct 1994||Zoran Milijasevic||Flow controllers for fluid infusion sets|
|US5363842||20 Dec 1991||15 Nov 1994||Circadian, Inc.||Intelligent inhaler providing feedback to both patient and medical professional|
|US5380281||6 Apr 1992||10 Jan 1995||Bracco, S.P.A.||Device for the administration of drugs, particularly two-component drugs|
|US5383851||24 Jul 1992||24 Jan 1995||Bioject Inc.||Needleless hypodermic injection device|
|US5394866 *||29 Jan 1993||7 Mar 1995||Aradigm Corporation||Automatic aerosol medication delivery system and methods|
|US5399163||23 Jul 1993||21 Mar 1995||Bioject Inc.||Needleless hypodermic injection methods and device|
|US5417660||22 Feb 1994||23 May 1995||T. A. Kershenstine||Self-locking syringe holder for use with a hypodermic syringe|
|US5466217||4 Apr 1994||14 Nov 1995||Alza Corporation||Iontophoretic drug delivery apparatus|
|US5514135||7 Jun 1995||7 May 1996||Earle; Michael L.||Bone cement delivery gun|
|US5558679||21 Aug 1995||24 Sep 1996||Micron Communications, Inc.||Method for mounting a battery on a substrate|
|US5567160||26 Oct 1995||22 Oct 1996||Survival Technology, Inc.||Autoinjector training device|
|US5568555||23 Nov 1994||22 Oct 1996||Colorcode Unlimited, Inc.||Multi-color information encoding system|
|US5569192||24 Mar 1993||29 Oct 1996||Duphar International Research B.V.||Automatic injector|
|US5584815||19 Apr 1995||17 Dec 1996||Eli Lilly And Company||Multi-cartridge medication injection device|
|US5615771||7 Apr 1993||1 Apr 1997||Smiths Industries Medical Systems, Inc.||Safety needle cartridge system|
|US5616132||12 Jun 1995||1 Apr 1997||Subot, Inc.||Injection device|
|US5645534||24 Jun 1994||8 Jul 1997||Becton Dickinson And Company||Time of last injection indicator for medication delivery pen|
|US5662612||26 Jun 1995||2 Sep 1997||Liebel Flarsheim Company||Controlling plunger drives for fluid injections in animals|
|US5681291||18 Oct 1993||28 Oct 1997||Tebro S.A.||Disposable auto-injector for prefilled syringes|
|US5692492||15 Feb 1994||2 Dec 1997||Valois S.A.||Hand-held inhalation-actuated spray device|
|US5695476||4 Nov 1994||9 Dec 1997||Harris; Ivan Paul||Needle protection assemblies|
|US5697916||21 Nov 1995||16 Dec 1997||Stat Medical Devices Inc.||Hypodermic dosage measuring device|
|US5716338||10 Oct 1994||10 Feb 1998||Pharmacia & Upjohn Aktiebolag||Dual-chamber type injection cartridge with bypass connection|
|US5772635||15 May 1995||30 Jun 1998||Alaris Medical Systems, Inc.||Automated infusion system with dose rate calculator|
|US5792190||17 Nov 1997||11 Aug 1998||Survivalink Corporation||Automated external defibrillator operator interface|
|US5800397||7 Oct 1997||1 Sep 1998||Invasatec, Inc.||Angiographic system with automatic high/low pressure switching|
|US5805423||17 May 1996||8 Sep 1998||United Technologies Automotive||Battery contact and retention apparatus for printed circuit boards|
|US5809997||10 Oct 1995||22 Sep 1998||Medtrac Technologies, Inc.||Electronic medication chronolog device|
|US5813397||25 Apr 1997||29 Sep 1998||Aradigm Corporation||Delivery of aerosol medication for inspiration|
|US5814020||6 Sep 1996||29 Sep 1998||Elan Medical Technlogies Limited||Medicament delivery device|
|US5823363||18 Oct 1996||20 Oct 1998||Cassel; Douglas||Medical syringe holding/transport apparatus|
|US5832488||22 Jan 1997||3 Nov 1998||Stuart S. Bowie||Computer system and method for storing medical histories using a smartcard to store data|
|US5837546||7 Jun 1996||17 Nov 1998||Metrika, Inc.||Electronic assay device and method|
|US5846089||7 Mar 1996||8 Dec 1998||Weiss; Richard C.||Medicine container for indicating patient information|
|US5848988||26 Jul 1996||15 Dec 1998||Alaris Medical Systems, Inc.||Infusion device with audible data output|
|US5852590||28 Mar 1997||22 Dec 1998||De La Huerga; Carlos||Interactive label for medication containers and dispensers|
|US5853292||8 May 1996||29 Dec 1998||Gaumard Scientific Company, Inc.||Computerized education system for teaching patient care|
|US5868713||3 Apr 1997||9 Feb 1999||L.O.M. Laboratories Inc.||Pneumatic retractable syringe|
|US5868721||1 May 1997||9 Feb 1999||Meridian Medical Technologies||Injection device having anti-coring needle|
|US5925021||24 Jul 1997||20 Jul 1999||Visionary Medical Products, Inc.||Medication delivery device with a microprocessor and characteristic monitor|
|US5928195||28 Jul 1998||27 Jul 1999||Malamud; Daniel||Remote control drug delivery device|
|US5941857||12 Sep 1997||24 Aug 1999||Becton Dickinson And Company||Disposable pen needle|
|US5964739||18 Jun 1998||12 Oct 1999||Champ; Raynido A.||Safety disposable needle structure|
|US5970457||30 Aug 1996||19 Oct 1999||Johns Hopkins University||Voice command and control medical care system|
|US5971953||9 Jan 1998||26 Oct 1999||Bachynsky; Nicholas||Dual chamber syringe apparatus|
|US5991655||26 Feb 1998||23 Nov 1999||Drug Delivery Systems, Inc.||Iontophoretic drug delivery device and method of manufacturing the same|
|US6015438||14 Nov 1997||18 Jan 2000||Retractable Technologies Inc.||Full displacement retractable syringe|
|US6039713||26 Aug 1998||21 Mar 2000||Mdc Investment Holdings, Inc.||Pre-filled retractable needle injection device|
|US6045534||27 Oct 1997||4 Apr 2000||Sarcos, Inc.||Disposable fluid injection module|
|US6062901||25 Jun 1998||16 May 2000||Hon Hai Precision Ind. Co., Ltd.||Low profile battery holder assembly for printed circuit board|
|US6063053||19 Dec 1998||16 May 2000||Visionary Medical Products Corp. Inc.||Gas pressured needle-less injection device and method|
|US6074213||17 Aug 1998||13 Jun 2000||Hon; David C.||Fractional process simulator with remote apparatus for multi-locational training of medical teams|
|US6077106||5 Jun 1997||20 Jun 2000||Micron Communications, Inc.||Thin profile battery mounting contact for printed circuit boards|
|US6084526||12 May 1999||4 Jul 2000||Time Warner Entertainment Co., L.P.||Container with means for displaying still and moving images|
|US6086562||1 Oct 1998||11 Jul 2000||Sarcos, Inc.||Disposable automatic injection device|
|US6096002||18 Nov 1998||1 Aug 2000||Bioject, Inc.||NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method|
|US6099504||21 Oct 1998||8 Aug 2000||Elan Corporation, Plc||Pre-filled injection delivery device|
|US6102896||8 Sep 1999||15 Aug 2000||Cambridge Biostability Limited||Disposable injector device|
|US6119684||21 Jun 1995||19 Sep 2000||Boehringer Ingelheim Kg||Aerosol inhaler|
|US6149626||30 Sep 1998||21 Nov 2000||Bachynsky; Nicholas||Automatic injecting syringe apparatus|
|US6158613||4 Jun 1998||12 Dec 2000||Voice Based Products, Inc.||Voice based pharmaceutical container apparatus and method for programming|
|US6161281||24 Feb 1999||19 Dec 2000||Micron Technology, Inc.||Battery mounting apparatuses, electronic devices, and methods of forming electrical connections|
|US6165155||16 Jan 1999||26 Dec 2000||Sarcos, Lc||Multipathway electronically-controlled drug delivery system|
|US6175752||30 Apr 1998||16 Jan 2001||Therasense, Inc.||Analyte monitoring device and methods of use|
|US6179812||13 Oct 1998||30 Jan 2001||Mdc Investment Holdings, Inc.||Retractable needle medical devices|
|US6192891||26 Apr 1999||27 Feb 2001||Becton Dickinson And Company||Integrated system including medication delivery pen, blood monitoring device, and lancer|
|US6193695||14 Jan 2000||27 Feb 2001||Wayland J. Rippstein, Jr.||Disposable safety syringe having a retractable needle|
|US6202642||23 Apr 1999||20 Mar 2001||Medtrac Technologies, Inc.||Electronic monitoring medication apparatus and method|
|US6210359||21 Jan 2000||3 Apr 2001||Jet Medica, L.L.C.||Needleless syringe|
|US6210369||16 Dec 1998||3 Apr 2001||Meridian Medical Technologies Inc.||Automatic injector|
|US6219587||27 May 1998||17 Apr 2001||Nextrx Corporation||Automated pharmaceutical management and dispensing system|
|US6221045||24 Oct 1997||24 Apr 2001||Acist Medical Systems, Inc.||Angiographic injector system with automatic high/low pressure switching|
|US6221055||1 Oct 1999||24 Apr 2001||Retractable Technologies, Inc.||Retractable dental syringe|
|US6245046||3 May 1999||12 Jun 2001||University Of New Mexico||Reciprocating syringes|
|US6258063||16 Jan 1998||10 Jul 2001||Roche Diagnostics Gmbh||Hypodermic injection system|
|US6259654||3 Nov 1998||10 Jul 2001||Telaric, L.L.C.||Multi-vial medication organizer and dispenser|
|US6264629||18 Feb 1999||24 Jul 2001||Bioject, Inc.||Single-use needle-less hypodermic jet injection apparatus and method|
|US6270455||30 Nov 1998||7 Aug 2001||Health Hero Network, Inc.||Networked system for interactive communications and remote monitoring of drug delivery|
|US6312412||2 Dec 1998||6 Nov 2001||V. C. Saied, M.D.||Apparatus and method for painless intramuscular or subcutaneous injections|
|US6317630||29 Jan 1999||13 Nov 2001||Yossi Gross||Drug delivery device|
|US6321654||24 Apr 2000||27 Nov 2001||The United States Of America As Represented By The Secretary Of The Army||Microelectromechanical systems (MEMS) -type devices having latch release and output mechanisms|
|US6334070||19 Nov 1999||25 Dec 2001||Medtronic Physio-Control Manufacturing Corp.||Visual and aural user interface for an automated external defibrillator|
|US6364866||22 Jan 1999||2 Apr 2002||Douglas Furr||Syringe loading aid|
|US6371939||24 Jan 2001||16 Apr 2002||Pharmacia Ab||Autoinjector|
|US6377848||25 Aug 1999||23 Apr 2002||Vyteris, Inc.||Devices activating an iontophoretic delivery device|
|US6387078||21 Dec 2000||14 May 2002||Gillespie, Iii Richard D.||Automatic mixing and injecting apparatus|
|US6398760||1 Oct 1999||4 Jun 2002||Baxter International, Inc.||Volumetric infusion pump with servo valve control|
|US6405912||1 Oct 1999||18 Jun 2002||Zoni Inc.||Protective case for carrying a fragile object|
|US6411567||7 Jul 2000||25 Jun 2002||Mark A. Niemiec||Drug delivery management system|
|US6413236||20 Jun 2000||2 Jul 2002||Lewis R. Van Dyke||Automatically retractable needle safety syringe|
|US6425897||10 Jan 2001||30 Jul 2002||Sulzer Orthopedics Ltd.||Pistol for the pressing out of bone cement with an attachable cement syringe|
|US6428517||17 Feb 2000||6 Aug 2002||Milestone Scientific, Inc.||Hand-piece for injection device with a retractable and rotating needle|
|US6428528||24 Feb 1999||6 Aug 2002||Antares Pharma, Inc.||Needle assisted jet injector|
|US6475181||3 Jul 1998||5 Nov 2002||Powderject Research Limited||Drug particle delivery|
|US6478769||22 Feb 2000||12 Nov 2002||The Board Of Trustees Of The University Of Arkansas||Anatomical fluid evacuation apparatus and method|
|US6478771||12 Nov 1999||12 Nov 2002||Elan Pharma International Limited||Drug delivery systems and methods|
|US6494863||15 Oct 2001||17 Dec 2002||Retractable Technologies, Inc.||One-use retracting syringe with positive needle retention|
|US6500150||23 Jun 1998||31 Dec 2002||Elan Pharma International Limited||Pre-filled drug-delivery device and method of manufacture and assembly of same|
|US6514230||28 Sep 2000||4 Feb 2003||Novo Nordisk A/S||Air shot mechanism for electronic injection devices|
|US6529446||28 Jul 2000||4 Mar 2003||Telaric L.L.C.||Interactive medication container|
|US6530900||23 May 2000||11 Mar 2003||Elan Pharma International Limited||Drug delivery device|
|US6530904||19 Jul 2001||11 Mar 2003||Evan T. Edwards||Medical injector|
|US6535714||2 Jul 2001||18 Mar 2003||University Of Florida||Method, system, and apparatus for medical device training|
|US6540672||29 Nov 1999||1 Apr 2003||Novo Nordisk A/S||Medical system and a method of controlling the system for use by a patient for medical self treatment|
|US6540675||20 Dec 2000||1 Apr 2003||Rosedale Medical, Inc.||Analyte monitor|
|US6544234||7 Aug 1998||8 Apr 2003||B D Medico S.A.R.L.||Injection device|
|US6551276||17 Dec 1999||22 Apr 2003||Medtronic Minimed, Inc.||External infusion device with remote programming bolus estimator and/or vibration alarm capabilities|
|US6551298||21 Nov 2000||22 Apr 2003||Jack Y. Zhang||Controlled medicament security enclosure system|
|US6554798||16 Jun 1999||29 Apr 2003||Medtronic Minimed, Inc.||External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities|
|US6558320||20 Jan 2000||6 May 2003||Medtronic Minimed, Inc.||Handheld personal data assistant (PDA) with a medical device and method of using the same|
|US6560471||2 Jan 2001||6 May 2003||Therasense, Inc.||Analyte monitoring device and methods of use|
|US6565533||21 Jan 2000||20 May 2003||Novus International, Inc.||Inoculation apparatus and method|
|US6569123||13 Apr 2001||27 May 2003||Becton, Dickinson And Company||Prefillable intradermal injector|
|US6572584||7 Aug 2000||3 Jun 2003||Retractable Technologies, Inc.||Retractable syringe with reduced retraction force|
|US6574166||9 Jul 2001||3 Jun 2003||Ddms Holdings, L.L.C.||Drug delivery management system|
|US6575939||21 Dec 1998||10 Jun 2003||Sanofi-Synthelabo||Device for automatic injection of a dose of medicinal product|
|US6585685||9 May 2002||1 Jul 2003||Bioject Inc.||Jet injector apparatus and method|
|US6585698||1 Nov 1999||1 Jul 2003||Becton, Dickinson & Company||Electronic medical delivery pen having a multifunction actuator|
|US6589158||17 Jan 2001||8 Jul 2003||Proxima Therapeutics, Inc.||Radiation shield for a syringe|
|US6595956||23 Mar 1999||22 Jul 2003||Joseph Gross||Drug delivery device|
|US6633796||14 Jun 2001||14 Oct 2003||Dan B. Pool||Medication timing device|
|US6641566||24 Jun 2002||4 Nov 2003||Sterling Medivations, Inc.||Reusable medication delivery device|
|US6645181||12 Nov 1999||11 Nov 2003||Elan Pharma International Limited||Drug delivery systems and methods|
|US6648850||8 Jun 2001||18 Nov 2003||Bioject, Inc.||Durable needle-less jet injector apparatus and method|
|US6659980||22 Nov 2002||9 Dec 2003||Medtronic Minimed Inc||Methods, apparatuses, and uses for infusion pump fluid pressure and force detection|
|US6676630||4 Jun 2002||13 Jan 2004||Bioject Medical Technologies, Inc.||Needle-free injection system|
|US6679862 *||23 Feb 2002||20 Jan 2004||Stryker Instruments||Integrated medication delivery system|
|US6689093||5 Feb 2001||10 Feb 2004||Bioject, Inc.||Single-use needle-less hypodermic jet injection apparatus and method|
|US6702778||8 Jun 2001||9 Mar 2004||Meridian Medical Technologies, Inc.||Wet/dry automatic injector assembly|
|US6707763||1 Feb 2002||16 Mar 2004||Diduminder Corporation||Closure cap including timer and cooperating switch member and associated methods|
|US6708050||28 Mar 2002||16 Mar 2004||3M Innovative Properties Company||Wireless electrode having activatable power cell|
|US6722916||30 Aug 2001||20 Apr 2004||Siemens Vdo Automotive Corporation||Surface battery clip|
|US6723077||28 Sep 2001||20 Apr 2004||Hewlett-Packard Development Company, L.P.||Cutaneous administration system|
|US6726661||10 Dec 2002||27 Apr 2004||Novo Nordisk A/S||Air shot mechanism for electronic injection devices|
|US6736796||26 Nov 2001||18 May 2004||Nili-Med Ltd.||Fluid drug delivery device|
|US6743635||1 Nov 2002||1 Jun 2004||Home Diagnostics, Inc.||System and methods for blood glucose sensing|
|US6749437||19 Dec 2001||15 Jun 2004||Thinking Technology, Inc.||Electronic display materials associated with products|
|US6752781||25 Jan 2002||22 Jun 2004||Sergio Landau||Durable hypodermic jet injector apparatus and method|
|US6767336||9 Jan 2003||27 Jul 2004||Sheldon Kaplan||Automatic injector|
|US6770052||9 Oct 2001||3 Aug 2004||Meridian Medical Technologies, Inc.||Wet/dry automatic injector assembly|
|US6783509||13 Sep 2000||31 Aug 2004||Bioject Inc.||Single-use needle-less hypodermic jet injection apparatus and method|
|US6786875||18 Apr 2001||7 Sep 2004||Mdc Investement Holdings, Inc.||Medical device with shield having a retractable needle|
|US6786885||22 Jan 2001||7 Sep 2004||Milestone Scientific Inc||Pressure/force computer controlled drug delivery system with exit pressure control|
|US6793646||6 Apr 2000||21 Sep 2004||Becton Dickinson And Company||Pen style injector with automated substance combining feature|
|US6803856||7 Sep 2000||12 Oct 2004||Hewlett-Packard Development Company, L.P.||Storage apparatus|
|US6808514||17 Oct 2001||26 Oct 2004||Patricia G. Schneider||Emergency medical dispensing card|
|US6809653||17 Dec 1999||26 Oct 2004||Medtronic Minimed, Inc.||Telemetered characteristic monitor system and method of using the same|
|US6817986||15 Apr 2002||16 Nov 2004||Avant Medical Corp.||Jet injector with data logging system for use in compliance and dose monitoring programs|
|US6830560||17 Jul 2000||14 Dec 2004||Elan Corporation Plc||Automatic syringe|
|US6839304||13 May 2002||4 Jan 2005||Ddms Holdings, L.L.C.||Drug delivery management system|
|US6872200||27 Mar 2003||29 Mar 2005||Medtronic Minimed, Inc.||External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities|
|US6875195||19 Sep 2001||5 Apr 2005||Soo Bong Choi||Portable automatic insulin syringe device with blood sugar measuring function|
|US6883222||16 Oct 2002||26 Apr 2005||Bioject Inc.||Drug cartridge assembly and method of manufacture|
|US6923764||22 Jan 2003||2 Aug 2005||Rosedale Medical, Inc.||Analyte monitor|
|US6936029||31 Jan 2002||30 Aug 2005||Medtronic Minimed, Inc.||External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities|
|US6937150||31 Dec 2003||30 Aug 2005||Medtronic Physio-Control Manufacturing Corp.||Method and system for locating a portable medical device|
|US6942646||21 Dec 2001||13 Sep 2005||Dca Design International Limited||Pen-type injector having an electronic control unit|
|US6946299||21 Apr 2003||20 Sep 2005||Home Diagnostics, Inc.||Systems and methods for blood glucose sensing|
|US6949082||21 Dec 2001||27 Sep 2005||Lea Design International Limited||Dosing means for an injection device|
|US6952604||21 Dec 2001||4 Oct 2005||Becton, Dickinson And Company||Minimally-invasive system and method for monitoring analyte levels|
|US6953445||9 Oct 2001||11 Oct 2005||Meridian Medical Technologies, Inc.||Wet/dry automatic injector assembly|
|US6953693||12 Nov 2003||11 Oct 2005||Home Diagnostics, Inc.||Systems and methods for blood glucose sensing|
|US6958691||22 Sep 2000||25 Oct 2005||Smithkline Beecham Corporation||Medicament delivery system|
|US6959247||12 Nov 2003||25 Oct 2005||Home Diagnostics, Inc.||Systems and methods for blood glucose sensing|
|US6961285||3 Sep 2002||1 Nov 2005||Ddms Holdings L.L.C.||Drug delivery management system|
|US6964650||19 Oct 2001||15 Nov 2005||Crossject||Needleless Safety Syringe of Compact Architecture|
|US6969259||26 Nov 2003||29 Nov 2005||Cardiac Science, Inc.||Programmable AED-CPR training device|
|US6979316||23 May 2002||27 Dec 2005||Seedlings Life Science Ventures Llc||Apparatus and method for rapid auto-injection of medication|
|US6979326||27 Mar 2003||27 Dec 2005||Medtronic Minimed, Inc.|
|US6985870||11 Jan 2002||10 Jan 2006||Baxter International Inc.||Medication delivery system|
|US6997911||29 May 2001||14 Feb 2006||Novo Nordisk A/S||Medication delivery device with replaceable cooperating modules and a method of making same|
|US7014470||16 Apr 2003||21 Mar 2006||High Plains Marketing||Risk Reduction teaching modules|
|US7093595||2 Oct 2002||22 Aug 2006||Eli Lilly And Company||Portable medication inhalation kit|
|US7113101||30 Dec 2002||26 Sep 2006||Intelligent Devices, Inc.||Blister package with electronic content monitoring system|
|US7116233||29 May 2003||3 Oct 2006||Mars Llc||Package provided with a sound-reproducing device|
|US7126879||9 Mar 2004||24 Oct 2006||Healthtrac Systems, Inc.||Medication package and method|
|US7158011||16 Feb 2004||2 Jan 2007||Brue Vesta L||Medication compliance device|
|US7191916||2 Nov 2004||20 Mar 2007||Alcon, Inc.||Device for dispensing fluid medicine|
|US7229458||31 Dec 2002||12 Jun 2007||Pelikan Technologies, Inc.||Method and apparatus for penetrating tissue|
|US7278983||22 Jul 2003||9 Oct 2007||Medtronic Minimed, Inc.||Physiological monitoring device for controlling a medication infusion device|
|US7299981||21 May 2002||27 Nov 2007||Scott Laboratories, Inc.||Smart supplies, components and capital equipment|
|US7343914||6 Sep 2002||18 Mar 2008||Microdose Technologies, Inc.||Adaptors for inhalers to improve performance|
|US7351223||30 Jan 2004||1 Apr 2008||Physicians Industries, Inc.||Infusion syringe with integrated pressure transducer|
|US7749194 *||1 Feb 2006||6 Jul 2010||Intelliject, Inc.||Devices, systems, and methods for medicament delivery|
|US7871393||13 Jul 2006||18 Jan 2011||Henry Schein, Inc.||Injection device with reporting ability|
|US8206360||4 Jun 2010||26 Jun 2012||Intelliject, Inc.||Devices, systems and methods for medicament delivery|
|US20010005781||24 Jan 2001||28 Jun 2001||Thomas Bergens||Autoinjector|
|US20020072784||10 Oct 2001||13 Jun 2002||Sheppard Norman F.||Microchip reservoir devices using wireless transmission of power and data|
|US20020074345||17 Oct 2001||20 Jun 2002||Schneider Patricia G.||Emergency medical dispensing card|
|US20020076679||19 Dec 2000||20 Jun 2002||Aman Craig S.||Web enabled medical device training|
|US20020090601||30 Jul 2001||11 Jul 2002||1263152 Ontario Inc.||Aerosol dispensing inhaler training device|
|US20020096543||22 Jan 2002||25 Jul 2002||Raimo Juselius||Device for monitoring the administration of doses and system for monitoring the administration of doses|
|US20020169439||22 Feb 2002||14 Nov 2002||Flaherty J. Christopher||Modular infusion device and method|
|US20020183721||31 May 2002||5 Dec 2002||Santini John T.||Microchip devices with improved reservoir opening|
|US20030028145||3 Jul 2002||6 Feb 2003||Duchon Douglas J.||Angiographic injector system with multiple processor redundancy|
|US20030040717||8 Aug 2002||27 Feb 2003||Becton, Dickinson And Company, A New Jersey Corporation||Retracting needle safety device|
|US20030100862||13 Jan 2003||29 May 2003||Edwards Evan T.||Medical injector|
|US20030105430||8 Nov 2002||5 Jun 2003||Elan Pharma International Limited Wil House||Automatic injector|
|US20030106824||1 Nov 2002||12 Jun 2003||Meridian Medical Technologies, Inc.||Medicament container, a medicament dispensing kit for administering medication and a method for packaging the same|
|US20030132128||4 Nov 2002||17 Jul 2003||Mazur David P.||Container for syringe|
|US20030135388||11 Jan 2002||17 Jul 2003||James Martucci||Medication delivery system|
|US20030233070||8 Nov 2002||18 Dec 2003||De La Serna Pedro E.||Pneumatic powered autoinjector|
|US20040015125||19 Oct 2001||22 Jan 2004||Patrick Alexandre||Compact architecture needleless syringe|
|US20040019326||24 Jun 2003||29 Jan 2004||Scott Gilbert||Reusable, spring driven autoinjector|
|US20040039336||14 Dec 2001||26 Feb 2004||Mikael Amark||Auto-injector|
|US20040039337||27 Feb 2003||26 Feb 2004||Letzing Michael Alexander||Portable safety auto-injector|
|US20040039368||17 Jun 2003||26 Feb 2004||Reilly David M.||Devices, systems and methods for injecting multiple fluids into a patient|
|US20040054327||20 Jun 2003||18 Mar 2004||Innoject Holdings, Inc.||Automatic mixing and injecting apparatus|
|US20040069667||10 Jun 2003||15 Apr 2004||Tomellini Dalita R.||Cases for medication delivery devices|
|US20040078001||21 Dec 2001||22 Apr 2004||Langley Christopher Nigel||Injection device with replacement cartridge|
|US20040116854||12 Dec 2002||17 Jun 2004||Abulhaj Ramzi F.||Syringe retractable needle and method|
|US20040138611||23 Oct 2003||15 Jul 2004||Meridian Medical Technologies, Inc.||Wet/dry automatic injector assembly|
|US20040143298||9 Jan 2004||22 Jul 2004||Nova Richard C.||Visual and aural user interface for an automated external defibrillator|
|US20040159364||19 Feb 2003||19 Aug 2004||Bioject Inc.||Needle-free injection system|
|US20040220524||7 Jun 2004||4 Nov 2004||Antares Pharma, Inc.||Needle assisted jet injector|
|US20040249358||8 Jun 2004||9 Dec 2004||Mcwethy Robert T.||Retractable needle medical device for injecting fluid from a pre-filled cartridge|
|US20040267204||26 Jun 2003||30 Dec 2004||Brustowicz Robert M.||On-demand needle retaining and locking mechanism for use in intravenous catheter assemblies|
|US20050033234||11 Aug 2004||10 Feb 2005||Sadowski Peter L.||Intradermal injector|
|US20050033386||15 Sep 2004||10 Feb 2005||Osborn Brett A.||System and method for remote programming of a medical device|
|US20050055014||4 Aug 2004||10 Mar 2005||Coppeta Jonathan R.||Methods for accelerated release of material from a reservoir device|
|US20050062603||5 Aug 2004||24 Mar 2005||Oren Fuerst||Secure, networked and wireless access, storage and retrival system and method utilizing tags and modular nodes|
|US20050088289||8 Oct 2004||28 Apr 2005||Marc Rochkind||Split-responsibility medication reminder system, and associated methods|
|US20050090781||13 Dec 2002||28 Apr 2005||Tokumi Baba||Administration instrument for medical use|
|US20050134433||18 Dec 2003||23 Jun 2005||Alysis Interactive Corporation||Remote identification of container contents by means of multiple radio frequency identification systems|
|US20050137530||22 Nov 2004||23 Jun 2005||Minimed Inc.||Infusion device menu structure and method of using the same|
|US20050148931||25 Oct 2004||7 Jul 2005||Juhasz Paul R.||Safety syringe|
|US20050148945||24 Dec 2003||7 Jul 2005||Chen Yong S.||Medical syringe|
|US20050159705||20 Jan 2004||21 Jul 2005||Becton, Dickinson And Company||Syringe having a retractable needle|
|US20050165360||28 Jan 2004||28 Jul 2005||Kevin Stamp||Injection device|
|US20050168337||30 Jan 2004||4 Aug 2005||Mahoney Jerome R.||Wirelessly loaded speaking medicine container|
|US20050171477||24 Mar 2005||4 Aug 2005||Seedlings Life Science Ventures||Apparatus and method for rapid auto-injection of medication|
|US20050182358||5 Nov 2004||18 Aug 2005||Veit Eric D.||Drug delivery pen with event notification means|
|US20050186221||1 Apr 2005||25 Aug 2005||Bailey Reynolds||Vaccine stabilizer method|
|US20050197654||9 Dec 2004||8 Sep 2005||Edman Carl F.||Multiple section parenteral drug delivery apparatus|
|US20050261742||25 Jul 2005||24 Nov 2005||Nova Richard C||Visual and aural user interface for an automated external defibrillator|
|US20050267403||28 May 2004||1 Dec 2005||Sergio Landau||Needle-free injection system|
|US20050277891||29 Apr 2005||15 Dec 2005||Science & Technology Corporation @ Unm||Reciprocating syringes|
|US20060030819||1 Apr 2005||9 Feb 2006||Meridian Medical Technologies Inc.||Automatic injector|
|US20060053036||7 Nov 2005||9 Mar 2006||Alaris Medical Systems, Inc.||Distributed remote asset and medication management drug delivery system|
|US20060058848||27 Oct 2005||16 Mar 2006||Medtronic Emergency Response Systems, Inc.||AED with user inputs in response to prompts|
|US20060111666||1 Sep 2005||25 May 2006||Edgar Hommann||Auto-pen for a two-chamber ampoule|
|US20060111671||2 Sep 2005||25 May 2006||L.O.M. Laboratories, Inc.||Single-use pneumatic safety syringe providing gas-driven needle retraction|
|US20060116639||29 Nov 2004||1 Jun 2006||Russell Claudia J||Total patient input monitoring|
|US20060129090||3 Dec 2004||15 Jun 2006||Medtronic Minimed, Inc.||Multi-position infusion set device and process|
|US20060189938||16 Feb 2006||24 Aug 2006||Edgar Hommann||Automatic injector with a release lock|
|US20060200077||18 Nov 2002||7 Sep 2006||Nardino Righi||Guard mechanism attachable to standard syringe to transform it into a safety syringe|
|US20060247579||13 Apr 2005||2 Nov 2006||Steven Friedman||Medicatioin injector|
|US20060265186||20 Feb 2004||23 Nov 2006||Holland Geoffrey N||Medication management system|
|US20070008113||9 Feb 2006||11 Jan 2007||Eastman Kodak Company||System to monitor the ingestion of medicines|
|US20070074722||21 Sep 2006||5 Apr 2007||Kurve Technology, Inc.||Medicament delivery control, monitoring, and reporting system and method|
|US20070088268||23 Nov 2004||19 Apr 2007||Edwards Eric S||Devices systems and methods for medicament delivery|
|US20070129708||5 Feb 2007||7 Jun 2007||Edwards Eric S||Devices, systems and methods for medicament delivery|
|US20070149925||21 Nov 2006||28 Jun 2007||Edwards Evan T||Devices, systems, and methods for medicament delivery|
|US20070184847||23 Aug 2006||9 Aug 2007||Novo Nordisk A/S||Method and a system for safe pairing of wireless communication devices|
|US20070203247||28 Feb 2007||30 Aug 2007||Elaine Phillips||Epinephrine dosing regimens|
|US20070210147||9 Mar 2006||13 Sep 2007||Jack Morrone||Pocket-size talking card or pamphlet device and packages containing the same|
|US20070213598||20 Feb 2004||13 Sep 2007||Howard Gary A||System for maintaining drug information and communicating with medication delivery devices|
|US20070233001||30 Mar 2005||4 Oct 2007||Burroughs Andrew C||Injection Apparatus Having a Needle Cassette for Delivering a Pharmaceutical Liquid|
|US20070239114||5 Jun 2007||11 Oct 2007||Edwards Eric S||Devices, systems and methods for medicament delivery|
|US20070239116||30 Oct 2006||11 Oct 2007||Mark Follman||Systems and methods for administering a medical regimen|
|US20070260210||2 May 2007||8 Nov 2007||Another Way Products, Inc.||Vibrating tampon apparatus with remote control|
|US20080033393||9 Jan 2007||7 Feb 2008||Edwards Eric S||Devices, systems and methods for medicament delivery|
|US20080058719||4 Dec 2006||6 Mar 2008||Edwards Evan T||Devices, systems and methods for medicament delivery|
|US20080059133||27 Feb 2007||6 Mar 2008||Edwards Eric S||Medical injector simulation device|
|US20080103490||28 Mar 2007||1 May 2008||Eric Shawn Edwards||Devices, systems and methods for medicament delivery|
|US20080111685||14 Sep 2007||15 May 2008||Olson Josiah N||Verbal warning systems and other audible warning systems for use with various types of devices, containers, products and other things|
|US20080160492||8 Aug 2007||3 Jul 2008||Insulet Corporation||Interactive training system and method|
|US20080230057||19 May 2006||25 Sep 2008||Garth Campbell Sutherland||Reminder For a Medicament Inhaler|
|US20080249468||13 Jun 2008||9 Oct 2008||Eric Shawn Edwards||Devices, systems and methods for medicament delivery|
|US20080269689||12 May 2008||30 Oct 2008||Edwards Eric S||Medicament delivery device having an electronic circuit system|
|US20080306436||1 Feb 2006||11 Dec 2008||Intelliject, Llc||Devices, Systems, and Methods for Medicament Delivery|
|US20090024112||22 Jan 2008||22 Jan 2009||Edwards Eric S||Medical injector with compliance tracking and monitoring|
|US20090143761||3 Dec 2007||4 Jun 2009||Transdermal Patents Company, Llc||Agent delivery system and uses of same|
|US20100022963||28 Jul 2008||28 Jan 2010||Edwards Eric S||Medicament delivery device configured to produce an audible output|
|US20100211005||10 Nov 2009||19 Aug 2010||Edwards Eric S||Apparatus and methods for self-administration of vaccines and other medicaments|
|US20120008811||16 Sep 2011||12 Jan 2012||Intelliject, Inc.||Medicament delivery device configured to produce an audible output|
|US20120116318||15 Dec 2011||10 May 2012||Intelliject, Inc.||Devices, systems and methods for medicament delivery|
|US20120226226||24 Feb 2012||6 Sep 2012||Intelliject Inc.||Devices, systems and methods for medicament delivery|
|USD407487||5 Aug 1997||30 Mar 1999||Hoechst Marion Roussel Duetschland||Medication delivery pen|
|USRE35986||24 Jul 1995||8 Dec 1998||Meridian Medical Technologies, Inc.||Multiple chamber automatic injector|
|USRE38189||28 Jul 1999||15 Jul 2003||Docusys, Inc.||Medication delivery and monitoring system and methods|
|EP1043037A2||4 Mar 2000||11 Oct 2000||B. Braun Melsungen Ag||A pen-type medicament injector|
|EP1287840A1||22 Aug 2002||5 Mar 2003||Japan Servo Co. Ltd.||Liquid infusion apparatus|
|EP1462134A1||13 Dec 2002||29 Sep 2004||Matsushita Electric Industrial Co., Ltd.||Administration instrument for medical use|
|EP1712178A2||22 Sep 2000||18 Oct 2006||Glaxo Group Limited||Medicament delivery system|
|MXPA04009276A||Title not available|
|WO1991004760A1||3 Oct 1990||18 Apr 1991||Den Haak Abraham Van||Injection syringe with automatically retractable needle|
|WO1993002720A1||6 Aug 1992||18 Feb 1993||Senetek Plc||Medicament injector and method|
|WO1995026009A1||21 Mar 1995||28 Sep 1995||Ibv Technologies, Inc.||Programmable voice instructed medication delivery and outcomes monitoring system|
|WO1997030742A1||20 Feb 1997||28 Aug 1997||Novo Nordisk A/S||Syringe with electronic representation of parameters|
|WO1999007425A1||6 Aug 1998||18 Feb 1999||Pharmacia & Upjohn Ab||Automated delivery device and method for its operation|
|WO1999043283A1||26 Feb 1999||2 Sep 1999||Raimo Juselius||Device and method for indicating an event of administration|
|WO2001024690A2||22 Sep 2000||12 Apr 2001||Glaxo Group Limited||Medicament delivery system|
|WO2001026020A1||22 Sep 2000||12 Apr 2001||Glaxo Group Limited||Patient data monitoring system|
|WO2001041849A3||8 Dec 2000||15 Nov 2001||Glaxo Group Ltd||Medicament dispenser|
|WO2001088828A3||18 May 2001||13 Mar 2003||Alaris Medical Syst Inc||Distributed remote asset and medication management drug delivery system|
|WO2001093926A2||8 Jun 2001||13 Dec 2001||Mayo Foundation For Medical Education And Research||Automated injection device for administration of liquid medicament|
|WO2002024257A1||19 Sep 2001||28 Mar 2002||Novo Nordisk A/S||A medication delivery device|
|WO2002051471A1||21 Dec 2001||4 Jul 2002||Dca Design International Limited||Drive mechanism for an injection device|
|WO2003057283A1||9 Jan 2003||17 Jul 2003||Dca Design International Limited||Improvements in and relating to medicament injection apparatus|
|WO2003095001A1||7 May 2003||20 Nov 2003||Glaxo Group Ltd||Injector in 'credit card' shape with shielded needle|
|WO2003097133A1||16 May 2003||27 Nov 2003||Owen Mumford Limited||Injection device with automatically retractable needle|
|WO2004022138A2||8 Sep 2003||18 Mar 2004||Massachusetts Institute Of Technology||Needless drug injection device|
|WO2004041330A2||4 Nov 2003||21 May 2004||M 2 Medical A/S||A disposable wearable insulin dispensing device, a combination of such a device and a programming controller and a method of controlling the operation of such a device|
|WO2005050526A2||12 Nov 2004||2 Jun 2005||Hospira, Inc.||System for maintaining drug information and communicating with medication delivery devices|
|WO2005077441A2||17 Feb 2005||25 Aug 2005||Ares Trading S.A.||Hand-held electronically controlled injection device for injecting liquid medications|
|WO2006045525A1||20 Oct 2005||4 May 2006||Novo Nordisk A/S||Injection device with a processor for collecting ejection information|
|WO2006085175A1||27 Jan 2006||17 Aug 2006||Ares Trading S.A.||Medication delivery device|
|WO2006085204A1||23 Jan 2006||17 Aug 2006||Ares Trading S.A.||Medication delivery device|
|WO2006109778A1||10 Apr 2006||19 Oct 2006||Nemoto Kyorindo Co., Ltd.||Medical liquid injection system|
|WO2006125692A1||6 Apr 2006||30 Nov 2006||Novo Nordisk A/S||A dosing operation in a medical device|
|WO2007088444A1||30 Jan 2007||9 Aug 2007||Ares Trading S.A.||Injection device with a capacitive proximity sensor|
|1||"Anaphylaxis Canada Product Catalogue," Anaphylaxis Canada > Living with Anaphylaxis > Tools and Resources [online] [retrieved on Jan. 24, 2007] Retrieved from the Internet .|
|2||"Anaphylaxis Canada Product Catalogue," Anaphylaxis Canada > Living with Anaphylaxis > Tools and Resources [online] [retrieved on Jan. 24, 2007] Retrieved from the Internet <URL: http://anaphylaxis.org/content/livingwith/product catalogue.asp >.|
|3||"Flex Circuits/flexible circuits design guide," [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet .|
|4||"Flex Circuits/flexible circuits design guide," [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet <URL: http://flexiblecircuit.co.uk/Flex Circuits Design Guide.htm >.|
|5||"Flexible circuits / Flex circuits / Flexible Technology Ltd.," Flexible Technology Limited [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet .|
|6||"Flexible circuits / Flex circuits / Flexible Technology Ltd.," Flexible Technology Limited [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet <URL: http://www.flexibletechnology.com/ >.|
|7||"Flexible circuits capabilities of Flexible Technology Limited," Our Flexible Circuits Capabilities [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet .|
|8||"Flexible circuits capabilities of Flexible Technology Limited," Our Flexible Circuits Capabilities [online] [retrieved on Aug. 28, 2006] Retrieved from the Internet <URL: http://www.flexibletechnology.com/Flexible circuits Capability.htm >.|
|9||"Insect Stings Auto-injector Pouches and Carry Cases," The Insect Stings On-Line Shop, [online] [retrieved on Jan. 24, 2007] Retrieved from the Internet .|
|10||"Insect Stings Auto-injector Pouches and Carry Cases," The Insect Stings On-Line Shop, [online] [retrieved on Jan. 24, 2007] Retrieved from the Internet <URL: http://www.insectstings.co.uk/acatalog/Auto Injector Pouches.html >.|
|11||"Merck Serono Launches easypod(R), First Electronic Growth Hormone Injection Device," Jan. 30, 2007 [online] [retrieved on Feb. 5, 2007] Retrieved from the Internet <URL: http://www.biz.yahoo.com/prnews/070130/ukm028.html?.v=8.|
|12||"Microfluidics Device Provides Programmed, Long-Term Drug Dosing," nano techwire.com [online] [retrieved on Nov. 28, 2006] Retrieved from the Internet .|
|13||"Microfluidics Device Provides Programmed, Long-Term Drug Dosing," nano techwire.com [online] [retrieved on Nov. 28, 2006] Retrieved from the Internet <URL: http://nanotechwire.com/news.asp?nid=3141&ntid=124&pg=1 >.|
|14||"Solutions for Medical Devices," 3M Brochure, © 3M 2006 80-6201-3490-0.|
|15||AED Professionals(TM) Brochure [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet .|
|16||AED Professionals™ Brochure [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.aedprofessionals.com/>.|
|17||Amgen, "Using Aranesp prefilled SureClick autoinjector is a simple 3-step process," 2006. [retrieved on Feb. 16, 2007] Retrieved from the Internet .|
|18||Amgen, "Using Aranesp prefilled SureClick autoinjector is a simple 3-step process," 2006. [retrieved on Feb. 16, 2007] Retrieved from the Internet <URL: http://www.aranesp.com/patient/cia/sureclick/using-three-steps.jsp/>.|
|19||CliniSense Corporation, "Drug delivery devices A potentially harsh environment for drugs," Stability [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet .|
|20||CliniSense Corporation, "Drug delivery devices A potentially harsh environment for drugs," Stability [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.clinisense.com/devices.htm>.|
|21||CliniSense Corporation, "LifeTrack Technology A new method to detect improper storage." Stability [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet .|
|22||CliniSense Corporation, "LifeTrack Technology A new method to detect improper storage." Stability [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.clinisense.com/tech.htm>.|
|23||Combined Search and Examination Report for GB 0818178.6, mailed Dec. 1, 2008.|
|24||Daniel Ruppar, "Implant Technologies Expected to Remain a Niche but Effective Method of Drug Delivery," Drug Delivery Technology, Feb. 2007, vol. 7, No. 2 [online] [retrieved on Jun. 1, 2007] Retrieved from the Internet <URL: http://www.drugdeliverytech-online.com/drugdelivery/200702/templates/pageviewer-print?pg=44&pm=8 >.|
|25||Dr. Oliver Scholz, "Drug depot in a tooth," [online] [retrieved on Feb. 6, 2006] Retrieved from the Internet <URL: http://www.fraunhofer.de/fhg/EN/press/pi/2007/02Mediendienst22007Thema2.jsp?print=tr.|
|26||Examination Report for British Patent Application No. 1019599.8, mailed Feb. 7, 2012.|
|27||Examination Report for British Patent Application No. GB 0818178.6, mailed Jul. 9, 2009.|
|28||Examination Report for British Patent Application No. GB 0818178.6, mailed Mar. 23, 2009.|
|29||Examination Report for British Patent Application No. GB 0905194.7, mailed May 8, 2009.|
|30||Final Office Action for U.S. Appl. No. 10/572,148, mailed Feb. 3, 2010.|
|31||Final Office Action for U.S. Appl. No. 11/621,236, mailed Jul. 1, 2009.|
|32||Final Office Action for U.S. Appl. No. 11/671,025, mailed Sep. 8, 2011.|
|33||Final Office Action for U.S. Appl. No. 11/679,331, mailed Feb. 15, 2011.|
|34||Heartsine Technology, samaritan(TM) Pad Accessories [online] [retrieved on Jun. 1, 2007].|
|35||Heartsine Technology, samaritan™ Pad Accessories [online] [retrieved on Jun. 1, 2007].|
|36||IPRP for International Patent Application No. PCT/US2007/084891, mailed Jun. 4, 2009.|
|37||Laura Lin Gosbee, "Nuts! I Can't Figure Out How to Use My Life-Saving Epinephrine Auto-Injector," Joint Commision Journal on Quality and Safety, vol. 30, No. 4, Apr. 2004.|
|38||Meridian Medical Technologies, Inc., "Pralidoxime Chloride Trainer," 2006. [retrieved on Feb. 16, 2007] Retrieved from the Internet .|
|39||Meridian Medical Technologies, Inc., "Pralidoxime Chloride Trainer," 2006. [retrieved on Feb. 16, 2007] Retrieved from the Internet <URL: http://www.meridianmeds.com/auto-injectors/2pamcl-trainer.html/>.|
|40||Merle Tingelstad, "Revolutionary Medical Technology Increases Demand for Flexible Interconnects," [online] May 15, 2006 [retrieved on Nov. 15, 2006] Retrieved from the Internet .|
|41||Merle Tingelstad, "Revolutionary Medical Technology Increases Demand for Flexible Interconnects," [online] May 15, 2006 [retrieved on Nov. 15, 2006] Retrieved from the Internet <URL: http://www.ecnmag.com/index.asp?layout=articlePrint&ArticleID=CA6332947 >.|
|42||Office Action for Canadian Application No. 2,762,072, mailed Oct. 28, 2013.|
|43||Office Action for European Patent Application No. 09150135.3, mailed Jul. 11, 2011.|
|44||Office Action for Israel Patent Application No. 184552, mailed Jul. 28, 2011.|
|45||Office Action for Japanese Patent Application No. JP2009-502964, mailed May 23, 2011.|
|46||Office Action for U.S. Appl. No. 10/572,148, mailed Jun. 19, 2009.|
|47||Office Action for U.S. Appl. No. 11/621,236, mailed Feb. 3, 2009.|
|48||Office Action for U.S. Appl. No. 11/621,236, mailed Jan. 11, 2010.|
|49||Office Action for U.S. Appl. No. 12/017,405, mailed Dec. 7, 2011.|
|50||Office Action for U.S. Appl. No. 12/119,016, mailed Nov. 3, 2011.|
|51||Office Action for U.S. Appl. No. 12/615,636, mailed Jan. 25, 2012.|
|52||Office Action for U.S. Appl. No. 12/794,020, mailed Oct. 25, 2011.|
|53||RFID Gazette, "Smart Labels in Healthcare," Sep. 29, 2005 [online] [retrieved on 11/28/06] Retrieved from the Internet .|
|54||RFID Gazette, "Smart Labels in Healthcare," Sep. 29, 2005 [online] [retrieved on 11/28/06] Retrieved from the Internet <URL: http://www.rfidagazeete.org/2005/09/smart labels in.html >.|
|55||Roger Allan, "Medical Electronics: Technology Advances Will Revolutionize Healthcare," Sep. 30, 2002 [online] [retrieved on Nov. 28, 2006] Retrieved from the Internet .|
|56||Roger Allan, "Medical Electronics: Technology Advances Will Revolutionize Healthcare," Sep. 30, 2002 [online] [retrieved on Nov. 28, 2006] Retrieved from the Internet <URL: http://www.elecdesign.com/Articles/Index.cfm?AD=1&ArticleID=2041>.|
|57||Search and Examination Report for Australian Patent Application No. 2012201481, mailed Nov. 30, 2012.|
|58||Search and Examination Report for British Patent Application No. 1104754.5, mailed May 18, 2011.|
|59||Search and Examination Report for British Patent Application No. 1108993.5, mailed Jun. 17, 2011.|
|60||Search Report and Written Opinion for International Patent Application No. PCT/US06/03415 mailed Jul. 13, 2006, 10 pages.|
|61||Search Report and Written Opinion for International Patent Application No. PCT/US07/007626 mailed Sep. 29, 2008.|
|62||Search Report and Written Opinion for International Patent Application No. PCT/US09/63983, mailed Feb. 25, 2010.|
|63||Search Report for EP 09150135.3, mailed Mar. 15, 2010.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US9022022||13 Jan 2014||5 May 2015||Kaleo, Inc.||Medicament delivery device for administration of opioid antagonists including formulations for naloxone|
|US9259539||27 Aug 2014||16 Feb 2016||Kaleo, Inc.||Devices, systems and methods for medicament delivery|
|US9278177||23 Mar 2015||8 Mar 2016||Kaleo, Inc.||Medical injector with compliance tracking and monitoring|
|US9278182||20 Mar 2015||8 Mar 2016||Kaleo, Inc.||Devices, systems and methods for medicament delivery|
|US9474869||23 Apr 2015||25 Oct 2016||Kaleo, Inc.||Medicament delivery device for administration of opioid antagonists including formulations for naloxone|
|US9517307||18 Jul 2014||13 Dec 2016||Kaleo, Inc.||Devices and methods for delivering opioid antagonists including formulations for naloxone|
|US9542826||26 Jun 2015||10 Jan 2017||Kaleo, Inc.||Devices, systems and methods for locating and interacting with medicament delivery systems|
|US9555191||16 Feb 2016||31 Jan 2017||Kaleo, Inc.||Apparatus and methods for self-administration of vaccines and other medicaments|
|US9555227||22 Jun 2015||31 Jan 2017||Chrono Therapeutics Inc.||Biosynchronous transdermal drug delivery|
|US9669199||2 May 2014||6 Jun 2017||Chrono Therapeutics Inc.||Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like|
|US9724471||3 Apr 2014||8 Aug 2017||Kaleo, Inc.||Devices, systems, and methods for medicament delivery|
|USRE46217||5 Feb 2015||29 Nov 2016||Chrono Therapeutics Inc.||Portable drug delivery device including a detachable and replaceable administration or dosing element|
|U.S. Classification||604/131, 604/140|
|Cooperative Classification||A61M5/19, A61M5/2033, A61M5/2066, A61M2005/2026, A61M2205/13, A61M2205/18, A61M2205/502, A61M2205/14, A61M2205/582, A61M2005/2073, A61M5/326, A61M2205/583, A61M2205/50, G06F19/3468, A61M5/3287, A61M2039/1083, A61M2205/581, A61M2205/6036, A61M5/24, A61M2205/3576, A61M2005/206, A61M2039/1088, A61M5/2053, A61M2205/6018|
|24 Jun 2010||AS||Assignment|
Owner name: INTELLIJECT, LLC, VIRGINIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:EDWARDS, ERIC S.;EDWARDS, EVAN T.;LICATA, MARK J.;REEL/FRAME:024590/0495
Effective date: 20061115
Owner name: INTELLIJECT, INC., VIRGINIA
Free format text: MERGER;ASSIGNOR:INTELLIJECT, LLC;REEL/FRAME:024590/0458
Effective date: 20081230
|14 Jan 2014||AS||Assignment|
Owner name: KALEO, INC., VIRGINIA
Free format text: CHANGE OF NAME;ASSIGNOR:INTELLIJECT, INC.;REEL/FRAME:032005/0932
Effective date: 20131203