US8220460B2 - Evacuation device and method for creating a localized pleurodesis - Google Patents
Evacuation device and method for creating a localized pleurodesis Download PDFInfo
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- US8220460B2 US8220460B2 US10/992,864 US99286404A US8220460B2 US 8220460 B2 US8220460 B2 US 8220460B2 US 99286404 A US99286404 A US 99286404A US 8220460 B2 US8220460 B2 US 8220460B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
- A61B17/3421—Cannulas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3415—Trocars; Puncturing needles for introducing tubes or catheters, e.g. gastrostomy tubes, drain catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M16/101—Preparation of respiratory gases or vapours with O2 features or with parameter measurement using an oxygen concentrator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/105—Filters
- A61M16/106—Filters in a path
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0252—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body for access to the lungs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0247—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body
- A61M2039/0276—Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body for introducing or removing fluids into or out of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/03—Gases in liquid phase, e.g. cryogenic liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/101—Pleural cavity
Definitions
- the present invention relates to systems and methods for treating diseased lungs, and more particularly, to a localized pleurodesis evacuation device for preventing a pneumothorax.
- oxygen therapy when provided, be as cost effective as possible.
- tracheotomy tubes are satisfactory for their intended purpose, they are not intended for chronic usage by outpatients as a means for delivering supplemental oxygen to spontaneously breathing patients with chronic obstructive pulmonary disease.
- Such tracheotomy tubes are generally designed so as to provide the total air supply to the patient for a relatively short period of time.
- the tracheotomy tubes are generally of rigid or semi-rigid construction and of caliber ranging from 2.5 mm outside diameter in infants to 15 mm outside diameter in adults. They are normally inserted in an operating room as a surgical procedure or during emergency situations, through the crico-thyroid membrane where the tissue is less vascular and the possibility of bleeding is reduced. These devices are intended to permit passage of air in both directions until normal breathing has been restored by other means.
- Jacobs U.S. Pat. Nos. 3,682,166 and 3,788,326.
- the catheter described therein is placed over 14 or 16-gauge needle and inserted through the crico-thyroid membrane for supplying air or oxygen and vacuum on an emergency basis to restore the breathing of a non-breathing patient.
- the air or oxygen is supplied at 30 to 100 psi for inflation and deflation of the patient's lungs.
- the Jacobs catheter like the other tracheotomy tubes previously used, is not suitable for long-term outpatient use, and could not easily be adapted to such use.
- transtracheal catheters Due to the limited functionality of tracheotomy tubes, transtracheal catheters have been proposed and used for long term supplemental oxygen therapy.
- the small diameter transtracheal catheter (16 gauge) developed by Dr. Henry J. Heimlich (described in THE ANNALS OF OTOLOGY, RHINOLOGY & LARYNGOLOGY, November-December 1982; Respiratory Rehabilitation with Transtracheal Oxygen System) has been used by the insertion of a relatively large cutting needle (14 gauge) into the trachea at the mid-point between the cricothyroid membrane and the sternal notch.
- This catheter size can supply oxygen up to about 3 liters per minute at low pressures, such as 2 psi which may be insufficient for patients who require higher flow rates.
- Chronic obstructive pulmonary disease diseases associated with chronic obstructive pulmonary disease include chronic bronchitis and emphysema.
- One aspect of an emphysematous lung is that the communicating flow of air between neighboring air sacs is much more prevalent as compared to healthy lungs. This phenomenon is known as collateral ventilation.
- Another aspect of an emphysematous lung is that air cannot be expelled from the native airways due to the loss of tissue elastic recoil and radial support of the airways. Essentially, the loss of elastic recoil of the lung tissue contributes to the inability of individuals to exhale completely. The loss of radial support of the airways also allows a collapsing phenomenon to occur during the expiratory phase of breathing.
- This collapsing phenomenon also intensifies the inability for individuals to exhale completely. As the inability to exhale completely increases, residual volume in the lungs also increases. This then causes the lung to establish in a hyperinflated state where an individual can only take short shallow breaths. Essentially, air is not effectively expelled and stale air accumulates in the lungs. Once the stale air accumulates in the lungs, the individual is deprived of oxygen.
- the present invention overcomes the limitations in treating diseases associated with chronic obstructive pulmonary disorders as briefly described above. In addition, the present invention overcomes the limitations associated with safety accessing the lungs.
- the present invention comprises a localized pleurodesis evacuation device comprising a removable conduit extending between the chest wall and the visceral pleura for evacuating air, a deployable, substantially flat structure attached to an end of the conduit, the conduit being substantially centered relative to the flat structure and a means affixed to the substantially flat structure operable to cause a localized pleurodesis.
- the present invention is directed to a device that may be utilized to evacuate air in the pleural space created by an opening in the thoracic wall. Once the air is evacuated, the visceral and parietal surfaces may join together and adhesions formed. With this local pleurodesis formed, the lung may be safely accessed through an access port in the device.
- FIG. 1 is a diagrammatic representation of a first exemplary embodiment of the long term oxygen therapy system in accordance with the present invention.
- FIG. 2 is a diagrammatic representation of a first exemplary embodiment of a sealing device utilized in conjunction with the long term oxygen therapy system of the present invention.
- FIG. 3 is a diagrammatic representation of a second exemplary embodiment of a sealing device utilized in conjunction with the long term oxygen therapy system of the present invention.
- FIG. 4 is a diagrammatic representation of a third exemplary embodiment of a sealing device utilized in conjunction with the long term oxygen therapy system of the present invention.
- FIG. 5 is a diagrammatic representation of a fourth exemplary embodiment of a sealing device utilized in conjunction with the long term oxygen therapy system of the present invention.
- FIG. 6 is a diagrammatic representation of a second exemplary embodiment of the long term oxygen therapy system in accordance with the present invention.
- FIG. 7 is a diagrammatic representation of a first exemplary embodiment of a collateral ventilation bypass trap system in accordance with the present invention.
- FIG. 8 is a diagrammatic representation of a second exemplary embodiment of a localized pleurodesis chemical delivery system.
- FIGS. 9 a and 9 b are diagrammatic representations of a localized pleurodesis evacuation device in accordance with the present invention.
- Air typically enters the mammalian body through the nostrils and flows into the nasal cavities. As the air passes through the nostrils and nasal cavities, it is filtered, moistened and raised or lowered to approximately body temperature. The back of the nasal cavities is continuous with the pharynx (throat region); therefore, air may reach the pharynx from the nasal cavities or from the mouth. Accordingly, if equipped, the mammal may breath through its nose or mouth. Generally air from the mouth is not as filtered or temperature regulated as air from the nostrils. The air in the pharynx flows from an opening in the floor of the pharynx and into the larynx (voice box).
- the epiglottis automatically closes off the larynx during swallowing so that solids and/or liquids enter the esophagus rather than the lower air passageways or airways.
- the air passes into the trachea, which divides into two branches, referred to as the bronchi.
- the bronchi are connected to the lungs.
- the lungs are large, paired, spongy, elastic organs, which are positioned in the thoracic cavity.
- the lungs are in contact with the walls of the thoracic cavity.
- the right lung comprises three lobes and the left lung comprises two lobes.
- Lungs are paired in all mammals, but the number of lobes or sections of lungs varies from mammal to mammal. Healthy lungs, as discussed below, have a tremendous surface area for gas/air exchange.
- Both the left and right lung is covered with a pleural membrane. Essentially, the pleural membrane around each lung forms a continuous sac that encloses the lung. A pleural membrane also forms a lining for the thoracic cavity.
- the space between the pleural membrane forming the lining of the thoracic cavity and the pleural membranes enclosing the lungs is referred to as the pleural cavity.
- the pleural cavity comprises a film of fluid that serves as a lubricant between the lungs and the chest wall.
- An extremely thin, single layer of epithelial cells lining each alveolus wall and an extremely thin, single layer of epithelial cells lining the capillary walls separate the air/gas in the alveolus from the blood.
- Oxygen molecules in higher concentration pass by simple diffusion through the two thin layers from the alveoli into the blood in the pulmonary capillaries.
- carbon dioxide molecules in higher concentration pass by simple diffusion through the two thin layers from the blood in the pulmonary capillaries into the alveoli.
- Breathing is a mechanical process involving inspiration and expiration.
- the thoracic cavity is normally a closed system and air cannot enter or leave the lungs except through the trachea. If the chest wall is somehow compromised and air/gas enters the pleural cavity, the lungs will typically collapse.
- the volume of the thoracic cavity is increased by the contraction of the diaphragm, the volume of the lungs is also increased.
- the pressure of the air in the lungs falls slightly below the pressure of the air external to the body (ambient air pressure). Accordingly, as a result of this slight pressure differential, external or ambient air flows through the respiratory passageways described above and fills the lungs until the pressure equalizes. This process is inspiration.
- the volume of the thoracic cavity decreases, which in turn decreases the volume of the lungs.
- the pressure of the air in the lungs rises slightly above the pressure of the air external to the body. Accordingly, as a result of this slight pressure differential, the air in the alveoli is expelled through the respiratory passageways until the pressure equalizes. This process is expiration.
- Chronic obstructive pulmonary disease is a persistent obstruction of the airways caused by chronic bronchitis and pulmonary emphysema. In the United States alone, approximately fourteen million people suffer from some form of chronic obstructive pulmonary disease and it is in the top ten leading causes of death.
- Chronic bronchitis and acute bronchitis share certain similar characteristics; however, they are distinct diseases. Both chronic and acute bronchitis involve inflammation and constriction of the bronchial tubes and the bronchioles; however, acute bronchitis is generally associated with a viral and/or bacterial infection and its duration is typically much shorter than chronic bronchitis. In chronic bronchitis, the bronchial tubes secrete too much mucus as part of the body's defensive mechanisms to inhaled foreign substances. Mucus membranes comprising ciliated cells (hair like structures) line the trachea and bronchi.
- the ciliated cells or cilia continuously push or sweep the mucus secreted from the mucus membranes in a direction away from the lungs and into the pharynx, where it is periodically swallowed.
- This sweeping action of the cilia functions to keep foreign matter from reaching the lungs.
- the ciliated cells may become damaged, leading to a decrease in the efficiency of the cilia to sweep the bronchial tubes and trachea of the mucus containing the foreign matter. This in turn causes the bronchioles to become constricted and inflamed and the individual becomes short of breath.
- the individual will develop a chronic cough as a means of attempting to clear the airways of excess mucus.
- Pulmonary emphysema is a disease in which the alveoli walls, which are normally fairly rigid structures, are destroyed. The destruction of the alveoli walls is irreversible. Pulmonary emphysema may be caused by a number of factors, including chronic bronchitis, long term exposure to inhaled irritants, e.g. air pollution, which damage the cilia, enzyme deficiencies and other pathological conditions. In pulmonary emphysema, the alveoli of the lungs lose their elasticity, and eventually the walls between adjacent alveoli are destroyed.
- oxygen therapy is widely accepted as the standard treatment for hypoxia caused by chronic obstructive pulmonary disease.
- oxygen therapy is prescribed using a nasal cannula.
- nasal cannula There are disadvantages associated with using the nasal cannula.
- One disadvantage associated with utilizing nasal cannula is the significant loss of oxygen between the cannula and the nose, which in turn equates to more frequent changes in the oxygen source, or higher energy requirements to generate more oxygen.
- Another disadvantage associated with utilizing nasal cannula is the fact that the cannulas may cause the nasal passages to become dry, cracked and sore.
- Transtracheal oxygen therapy has become a viable alternative to long term oxygen therapy.
- Transtracheal oxygen therapy delivers oxygen directly to the lungs using a catheter that is placed through and down the trachea. Due to the direct nature of the oxygen delivery, a number of advantages are achieved. These advantages include lower oxygen requirements due to greater efficiency, increased mobility, greater exercise capability and improved self image.
- the long term oxygen therapy system and method of the present invention may be utilized to deliver oxygen directly into the lung tissue in order to optimize oxygen transfer efficiency in the lungs.
- improved efficiency may be achieved if oxygen were to be delivered directly into the alveolar tissue in the lungs.
- alveoli walls are destroyed, thereby causing a decrease in air exchange surface area.
- collateral ventilation resistance is lowered.
- pulmonary emphysema causes an increase in collateral ventilation and to a certain extent, chronic bronchitis also causes an increase in collateral ventilation.
- collateral ventilation the communicating flow of air between neighboring air sacs (alveoli), known as collateral ventilation, is much more prevalent as compared to a normal lung. Since air cannot be expelled from the native airways due to the loss of tissue elastic recoil and radial support of the airways (dynamic collapse during exhalation), the increase in collateral ventilation does not significantly assist an individual in breathing. The individual develops dsypnea. Accordingly, if it can be determined where collateral ventilation is occurring, then the diseased lung tissue may be isolated and the oxygen delivered to this precise location or locations.
- Various methods may be utilized to determine the diseased tissue locations, for example, computerized axial tomography or CAT scans, magnetic resonance imaging or MRI, positron emission tomograph or PET, and/or standard X-ray imaging.
- pressurized oxygen may be directly delivered to these diseased areas and more effectively and efficiently forced into the lung tissue for air exchange.
- FIG. 1 illustrates a first exemplary long term oxygen therapy system 100 .
- the system 100 comprises an oxygen source 102 , an oxygen carrying conduit 104 and a one-way valve 106 .
- the oxygen source 102 may comprise any suitable device for supplying filtered oxygen under adjustably regulated pressures and flow rates, including pressurized oxygen tanks, liquid oxygen reservoirs, oxygen concentrators and the associated devices for controlling pressure and flow rate e.g. regulators.
- the oxygen carrying conduit 104 may comprise any suitable biocompatible tubing having a high resistance to damage caused by continuous oxygen exposure.
- the oxygen carrying conduit 104 comprises tubing having an inside diameter in the range from about 1/16 inch to about 1 ⁇ 2 inch and more preferably from about 1 ⁇ 8 inch to about 1 ⁇ 4 inch.
- the one-way valve 106 may comprise any suitable, in-line mechanical valve which allows oxygen to flow into the lungs 108 through the oxygen carrying conduit 104 , but not from the lungs 108 back into the oxygen source 102 .
- a simple check valve may be utilized.
- the oxygen carrying conduit 104 passes through the lung 108 at the site determined to have the highest degree of collateral ventilation.
- the exemplary system 100 described above may be modified in a number of ways, including the use of an in-line filter.
- both oxygen and air may flow through the system.
- oxygen is delivered to the lungs through the oxygen carrying conduit 104 and during exhalation, air from the lungs flow through the oxygen carrying conduit 104 .
- the in-line filter would trap mucus and other contaminants, thereby preventing a blockage in the oxygen source 102 .
- no valve 106 would be utilized.
- the flow of oxygen into the lungs and the flow of air from the lungs is based on pressure differentials.
- an air-tight seal is preferably maintained where the oxygen carrying conduit 104 passes through the thoracic cavity and lung. This seal is maintained in order to sustain the inflation/functionality of the lungs. If the seal is breached, air can enter the cavity and cause the lungs to collapse as described above.
- a method to create this seal comprises forming adhesions between the visceral pleura of the lung and the inner wall of the thoracic cavity. This may be achieved using either chemical methods, including irritants such as Doxycycline and/or Bleomycin, surgical methods, including pleurectomy or thoracoscope talc pleurodesis, or radiotherapy methods, including radioactive gold or external radiation. All of these methods are known in the relevant art for creating pleurodesis. With a seal created at the site for the ventilation bypass, an intervention may be safely performed without the danger of creating a pneumothorax of the lung.
- the oxygen carrying conduit 104 may be sealed to the skin at the site of the ventilation bypass.
- the oxygen carrying conduit 104 may be sealed to the skin of the thoracic wall utilizing an adhesive.
- the oxygen carrying conduit 104 comprises a flange 200 having a biocompatible adhesive coating on the skin contacting surface.
- the biocompatible adhesive would provide a fluid tight seal between the flange 200 and the skin or epidermis of the thoracic wall.
- the biocompatible adhesive provides a temporary fluid tight seal such that the oxygen carrying conduit 104 may be disconnected from the ventilation bypass site. This would allow for the site to be cleaned and for the long term oxygen therapy system 100 to undergo periodic maintenance.
- FIG. 3 illustrates another exemplary embodiment for sealing the oxygen carrying conduit 104 to the skin of the thoracic wall at the site of the ventilation bypass.
- a coupling plate 300 is sealed to the skin at the site of the ventilation bypass by a biocompatible adhesive coating or any other suitable means.
- the oxygen carrying conduit 104 is then connected to the coupling plate 300 by any suitable means, including threaded couplings and locking rings.
- the exemplary embodiment also allows for cleaning of the site and maintenance of the system 100 .
- FIG. 4 illustrates yet another exemplary embodiment for sealing the oxygen carrying conduit 104 to the skin of the thoracic wall at the site of the ventilation bypass.
- balloon flanges 400 may be utilized to create the seal.
- the balloon flanges 400 may be attached to the oxygen carrying conduit 104 such that in the deflated state, the oxygen carrying conduit 104 and one of the balloon flanges passes through the ventilation bypass anastomosis.
- the balloon flanges 400 are spaced apart a sufficient distance such that the balloon flanges remain on opposite sides of the thoracic wall. When inflated, the balloons expand and form a fluid tight seal by sandwiching the thoracic wall.
- this exemplary embodiment allows for easy removal of the oxygen carrying conduit 104 .
- FIG. 5 illustrates yet another exemplary embodiment for sealing the oxygen carrying conduit 104 to the skin of the thoracic wall at the site of the ventilation bypass.
- a single balloon flange 500 is utilized in combination with a fixed flange 502 .
- the balloon flange 500 is connected to the oxygen carrying conduit 104 in the same manner as described above.
- the balloon flange 500 when inflated, forms the fluid tight seal.
- the fixed flange 502 which is maintained against the skin of the thoracic wall, provides the structural support against which the balloon exerts pressure to form the seal.
- FIG. 6 illustrates an exemplary embodiment of a collateral ventilation bypass/direct oxygen therapy system 600 .
- the system 600 comprises an oxygen source 602 , an oxygen carrying conduit 604 having two branches 606 and 608 , and a control valve 610 .
- the oxygen source 602 and oxygen carrying conduit 604 may comprise components similar to the above-described exemplary embodiment illustrated in FIG. 1 .
- the valve 610 when the individual inhales, the valve 610 is open and oxygen flows into the lung 612 and into the bronchial tube 614 .
- the branch 608 may be connected to the trachea 616 .
- oxygen flows to the diseased site in the lung or lungs and to other parts of the lung through the normal bronchial passages.
- the valve 610 is closed so that no oxygen is delivered and air in the diseased portion of the lung may flow from the lung 612 , through one branch 606 and into the second branch 608 and finally into the bronchial tube 616 .
- stale air is removed and oxygen is directly delivered.
- connection and sealing of the oxygen carrying conduit 604 and branches 606 , 608 to the lung 612 and bronchial tube 614 may be made in a manner similar to that described above.
- emphysema is distinguished as irreversible damage to lung tissue.
- the breakdown of lung tissue leads to the reduced ability for the lungs to recoil.
- the tissue breakdown also leads to the loss of radial support of the native airways. Consequently, the loss of elastic recoil of the lung tissue contributes to the inability for individuals with emphysema to exhale completely.
- the loss of radial support of the native airways also allows a collapsing phenomenon to occur during the expiratory phase of breathing.
- the collateral ventilation bypass trap system of the present invention utilizes the above-described collateral ventilation phenomenon to increase the expiratory flow from a diseased lung or lungs, thereby treating another aspect of chronic obstructive pulmonary disease.
- the most collaterally ventilated area of the lung or lungs is determined utilizing the scanning techniques described above. Once this area or areas are located, a conduit or conduits are positioned in a passage or passages that access the outer pleural layer of the diseased lung or lungs.
- the conduit or conduits utilize the collateral ventilation of the lung or lungs and allows the entrapped air to bypass the native airways and be expelled to a containment system outside of the body.
- FIG. 7 illustrates a first exemplary collateral ventilation bypass trap system 700 .
- the system 700 comprises a trap 702 , an air carrying conduit 704 and a filter/one-way valve 706 .
- the air carrying conduit 704 creates a fluid communication between an individual's lung 708 and the trap 702 through the filter/one-way valve 706 . It is important to note that although a single conduit 704 is illustrated, multiple conduits may be utilized in each lung 708 if it is determined that there are more than one area of high collateral ventilation.
- the trap 702 may comprise any suitable device for collecting discharge from the individual's lung or lungs 708 .
- the trap 702 is simply a containment vessel for temporarily storing discharge from the lungs, for example, mucous and other fluids that may accumulate in the lungs.
- the trap 702 may comprise any suitable shape and may be formed from any suitable metallic or non-metallic materials.
- the trap 702 should be formed from a lightweight, non-corrosive material.
- the trap 702 should be designed in such a manner as to allow for effective and efficient cleaning.
- the trap 702 may comprise disposable liners that may be removed when the trap 702 is full.
- the trap 702 may be formed from a transparent material or comprise an indicator window so that it may be easily determined when the trap 702 should be emptied or cleaned.
- a lightweight trap 702 increases the patient's mobility.
- the filter/one-way valve 706 may be attached to the trap 702 by any suitable means, including threaded fittings or compression type fittings commonly utilized in compressor connections.
- the filter/one-way valve 706 serves a number of functions.
- the filter/one-way valve 706 allows the air from the individual's lung or lungs 708 to exit the trap 702 while maintaining the fluid discharge and solid particulate matter in the trap 702 .
- This filter/one-way valve 706 would essentially maintain the pressure in the trap 702 below that of the pressure inside the individual's lung or lungs 708 so that the flow of air from the lungs 708 to the trap 702 is maintained in this one direction.
- the filter portion of the filter/one-way valve 706 may be designed to capture particulate matter of a particular size which is suspended in the air, but allows the clean air to pass therethrough and be vented to the ambient environment.
- the filter portion may also be designed in such a manner as to reduce the moisture content of the exhaled air.
- the air carrying conduit 704 connects the trap 702 to the lung or lungs 708 of the patient through the filter/one-way valve 706 .
- the air carrying conduit 704 may comprise any suitable biocompatible tubing having a resistance to the gases contained in air.
- the air carrying conduit 704 comprises tubing having an inside diameter in the range from about 1/16 inch to about 1 ⁇ 2 inch, and more preferably from about 1 ⁇ 8 inch to about 1 ⁇ 4 inch.
- the filter/one-way valve 706 may comprise any suitable valve which allows air to flow from the lung or lungs 708 through the air carrying conduit 704 , but not from the trap 702 back to the lungs 708 .
- a simple check valve may be utilized.
- the air carrying conduit 704 may be connected to the filter/one-way valve 706 by any suitable means. Preferably, a quick release mechanism is utilized so that the trap may be easily removed for maintenance.
- the air carrying conduit 704 passes through the lung 708 at the site determined to have the highest degree of collateral ventilation. If more than one site is determined, multiple air carrying conduits 704 may be utilized.
- the connection of multiple air carrying conduits 704 to the filter/one-way valve 706 may be accomplished by any suitable means, including an octopus device similar to that utilized in scuba diving regulators.
- the air carrying conduit 704 is preferably able to withstand and resist collapsing once in place. Since air will travel through the conduit 704 , if the conduit is crushed and unable to recover, the effectiveness of the system is diminished. Accordingly, a crush recoverable material may be incorporated into the air carrying conduit 704 in order to make it crush recoverable. Any number of suitable materials may be utilized. For example, Nitinol incorporated into the conduit 704 will give the conduit collapse resistance and collapse recovery properties.
- Expandable features at the end of the conduit 704 may be used to aid in maintaining contact and sealing the conduit 704 to the lung pleura. Nitinol incorporated into the conduit 704 will provide the ability to deliver the conduit 704 in a compressed state and then deployed in an expanded state to secure it in place. Shoulders at the end of the conduit may also provide a mechanical stop for insertion and an area for an adhesive/sealant to join as described in detail subsequently.
- an air-tight seal is preferably maintained where the air carrying conduit 704 passes through the thoracic cavity and lungs 708 .
- This seal is maintained in order to sustain the inflation/functionality of the lungs. If the seal is breached, air can enter the cavity and cause the lungs to collapse.
- One exemplary method for creating the seal comprises forming adhesions between the visceral pleura of the lung and the inner wall of the thoracic cavity. This may be achieved using either chemical methods, including irritants such as Doxycycline and/or Bleomycin, surgical methods, including pleurectomy or thorascopic talc pleurodesis, or radiotherapy methods, including radioactive gold or external radiation.
- a sealed joint between the air carrying conduit 704 and the outer pleural layer includes using various glues to help with the adhesion/sealing of the air carrying conduit 704 .
- Focal Inc. markets a sealant available under the tradename Focal/Seal-L which is indicated for use on a lung for sealing purposes. Focal/Seal-L is activated by light in order to cure the sealant.
- Thorex is a two-part sealant that has a set curing time after the two parts are mixed.
- the creation of the opening in the chest cavity may be accomplished in a number of ways.
- the procedure may be accomplished using an open chest procedure, sternotomy or thoracotomy.
- the procedure may be accomplished using a laparoscopic technique, which is less invasive.
- the seal should be established while the lung is at least partially inflated in order to maintain a solid adhesive surface.
- the opening may then be made after the joint has been adequately created between the conduit component and the lung pleural surface.
- the opening should be adequate in cross-sectional area in order to provide sufficient decompression of the hyperinflated lung.
- This opening may be created using a number of different techniques such as cutting, piercing, dilating, blunt dissection, radio frequency energy, ultrasonic energy, microwave energy, or cryoblative energy.
- the air carrying conduit 704 may be sealed to the skin at the site by any of the means and methods described above with respect to the oxygen carrying conduit 704 and illustrated in FIGS. 2 through 5 .
- a pneumothorax (collapsed lung) may occur. Essentially, in any circumstance where the lung is punctured and a device inserted, an air-tight seal should preferably be maintained.
- pleurodesis i.e. an obliteration of the pleural space.
- pleurodesis methods including chemical, surgical and radiological.
- chemical pleurodesis an agent such as tetracycline, doxycycline, bleomycin or nitrogen mustard may be utilized.
- surgical pleurodesis a pleurectomy or a thoracoscopic talc procedure may be performed.
- radiological procedures radioactive gold or external radiation may be utilized.
- chemical pleurodesis is utilized.
- Exemplary devices and methods for delivering a chemical(s) or agent(s) in a localized manner for ensuring a proper air-tight seal of the above-described apparatus is described below.
- the chemical(s), agent(s) and/or compound(s) are used to create a pleurodesis between the parietal and visceral pleura so that a component of the apparatus may penetrate through the particular area and not result in a pneumothorax.
- the chemical(s), agent(s) and/or compound(s) include talc, tetracycline, doxycycline, bleomycin and minocycline.
- a modified drug delivery catheter may be utilized to deliver chemical(s), agent(s) and/or compound(s) to a localized area for creating a pleurodesis in that area.
- the pleurodesis is formed and then the conduit 704 , as illustrated in FIG. 7 , is positioned in the lung 708 through the area of the pleurodesis.
- the drug delivery catheter provides a minimally invasive means for creating a localized pleurodesis.
- a local drug delivery device may be utilized to deliver the pleurodesis chemical(s), agent(s) and/or compound(s).
- the pleurodesis is formed and then the conduit 704 , as illustrated in FIG. 7 , is positioned in the lung 708 through the pleurodesis.
- chemical(s), agent(s) and/or compound(s) may be affixed to an implantable medical device. The medical device is then implanted in the pleural cavity at a particular site and the chemical(s), agent(s) and/or compound(s) are released therefrom to form or create the pleurodesis.
- any of the above-described chemical(s), agent(s) and/or compound(s) may be affixed to the medical device.
- the chemical(s), agent(s) and/or compound(s) may be affixed to the medical device in any suitable manner.
- the chemical(s), agent(s) and/or compound(s) may be coated on the device utilizing any number of well known techniques including, spin coating, spraying or dipping, they may be incorporated into a polymeric matrix that is affixed to the surface of the medical device, they may be impregnated into the outer surface of the medical device, they may be incorporated into holes or chambers in the medical device, they may be coated onto the surface of the medical device and then coated with a polymeric layer that acts as a diffusion barrier for controlled release of the chemical(s), agent(s) and/or compound(s), they may be incorporated directly into the material forming the medical device, or any combination of the above-described techniques.
- the medical device may be formed from a biodegradable material which elutes the chemical(s), agent(s) and/or compound(s) as the device degrades.
- the implantable medical device may comprise any suitable size, shape and/or configuration, and may be formed using any suitable biocompatible material.
- FIG. 8 illustrates one exemplary embodiment of an implantable medical device 900 .
- the implantable medical device 900 comprises a substantially cylindrical disk 900 .
- the disk 900 is positioned in the pleural space 902 between the thoracic wall 904 and the lung 906 . Once in position, the disk 900 elutes or otherwise releases the chemical(s), agent(s) and/or compound(s) that form the pleurodesis.
- the release rate may be precisely controlled by using any of the various techniques described above, for example, a polymeric diffusion barrier.
- the disk 900 may be formed from a biodegradable material that elutes the chemical(s), agent(s) and/or compound(s) as the disk 900 itself disintegrates or dissolves.
- a non-biodegradable disk 900 may or may not require removal from the pleural cavity 902 once the pleurodesis is formed.
- the disk 900 may comprise a radiopaque marker or be formed from a radiopaque material.
- the radiopaque marker or material allows the disk 900 to be seen under fluoroscopy and then positioned accurately.
- the fluid characteristics of the chemical(s), agent(s) and/or compound(s) may be altered.
- the chemical(s), agent(s) and/or compound(s) may be made more viscous. With a more viscous chemical agent and/or compound, there would be less chance of the chemical, agent and/or compound moving from the desired location in the pleural space.
- the chemical(s), agent(s) and/or compound(s) may also comprise radiopaque constituents. Making the chemical(s), agent(s) and/or compounds radiopaque would allow the confirmation of the location of the chemical(s), agent(s) and/or compound(s) with regard to the optimal location of collateral ventilation.
- chemical(s), agent(s) and/or compound(s) as modified above may be utilized in conjunction with standard chemical pleurodesis devices and processes or in conjunction with the exemplary embodiments set forth above.
- a localized pleurodesis evacuation device may be utilized to evacuate air in the pleural space so that a pneumothorax will not result. Access may be made through the thoracic wall into the pleural space without creating an opening into the lung. With this approach, the only avenue for air leakage into the pleural space will be through the thoracic wall access. Similar to a pleural drainage catheter or chest tube, a device may be placed through the thoracic wall that evacuates air leaking into the pleural space thereby preventing a pneumothorax. In addition, if this device is left in the pleural space, it may create an adhesion around itself, thereby forming a local pleurodesis.
- the lung may be safely accessed for placement of any of the above devices, or access to the lung in general, for example, for the delivery of drugs.
- the localized pleurodesis evacuation device of the present invention provides a local area of evacuation and subsequently a local area of adhesion.
- the device may be configured to deliver chemicals or agents that may induce an adhesion and provide a channel that will access the lung within the adhesion created.
- the evacuation component of the device is preferably concentric to the access point through the thoracic wall. Accordingly, any adhesion forming around the device would substantially surround the access point. This would allow access into the lung with a seal to prevent a pneumothorax. In other words, the location of the adhesion and access point does not become an issue.
- the device 1000 comprises an access port 1002 and an evacuation structure 1004 .
- the evacuation device 1000 may be inserted into the pleural space utilizing any number of well known techniques including surgical intervention or minimally invasive placement through the use of a trocar.
- the evacuation device 1000 may be positioned in the intercostal space between the ribs 1006 or alternately in an artificial bridge formed between two or more ribs.
- the evacuation device 1000 may also comprise an external seal 1008 for creating a seal between the access port 1002 and the skin of the thoracic wall.
- the seal 1008 may comprise any suitable device as described herein.
- the access port 1002 may comprise any suitable configuration and is preferably sized to accommodate any number of devices for accessing the lung.
- the access port is a substantially tubular structure.
- the evacuation structure 1004 is concentrically positioned around the access port 1002 . It is positioned between the visceral pleura 1010 and the parietal pleura 1012 proximate the visceral pleura.
- the evacuation structure 1004 comprises a substantially flat disc with a plurality of holes 1014 that are in fluid communication with the access port 1002 . Air in the pleural space enters the holes 1014 and exits the body through the access port 1002 .
- valves and/or check flaps may be utilized to ensure that air flows only from the pleural space and not into the pleural space.
- the visceral and parietal pleurae come into contact, as illustrated in FIG. 9 b , thereby substantially reducing the risk of a pneumothorax.
- an adhesion forms around the evacuation structure 1004 . Once the adhesion forms (pleurodesis), the lung may be safely accessed in terms of air leaks.
- the access port 1002 and the evacuation structure 1004 may be formed using any suitable biocompatible materials.
- the evacuation structure 1004 may be coated or impregnated with a chemical or chemicals that facilitate the formation of adhesion as discussed herein.
- the evacuation device 1000 may also comprise a separate device for the delivery of adhesion forming chemicals that may be evacuated through the holes 1014 in the evacuation structure 1004 if desired.
- the evacuation structure may also be fabricated from an absorbable material.
Abstract
Description
Claims (25)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
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US10/992,864 US8220460B2 (en) | 2004-11-19 | 2004-11-19 | Evacuation device and method for creating a localized pleurodesis |
EP05257059A EP1658867B1 (en) | 2004-11-19 | 2005-11-16 | Localized pleurodesis evacuation device |
DE602005007680T DE602005007680D1 (en) | 2004-11-19 | 2005-11-16 | Evacuation device for limited pleurodesis |
AT05257059T ATE399031T1 (en) | 2004-11-19 | 2005-11-16 | EVACUATION DEVICE FOR LIMITED PLEURODESIS |
CA002527517A CA2527517A1 (en) | 2004-11-19 | 2005-11-17 | Localized pleurodesis evacuation device |
JP2005334592A JP2006142028A (en) | 2004-11-19 | 2005-11-18 | Localized pleurodesis evacuation device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US10/992,864 US8220460B2 (en) | 2004-11-19 | 2004-11-19 | Evacuation device and method for creating a localized pleurodesis |
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US8220460B2 true US8220460B2 (en) | 2012-07-17 |
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US10/992,864 Expired - Fee Related US8220460B2 (en) | 2004-11-19 | 2004-11-19 | Evacuation device and method for creating a localized pleurodesis |
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EP (1) | EP1658867B1 (en) |
JP (1) | JP2006142028A (en) |
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CA2527517A1 (en) | 2006-05-19 |
JP2006142028A (en) | 2006-06-08 |
EP1658867A1 (en) | 2006-05-24 |
US20060107961A1 (en) | 2006-05-25 |
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ATE399031T1 (en) | 2008-07-15 |
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