US7628764B2 - Ultrasonic treatment for wounds - Google Patents
Ultrasonic treatment for wounds Download PDFInfo
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- US7628764B2 US7628764B2 US09/928,594 US92859401A US7628764B2 US 7628764 B2 US7628764 B2 US 7628764B2 US 92859401 A US92859401 A US 92859401A US 7628764 B2 US7628764 B2 US 7628764B2
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- wound
- transducer
- ultrasonic
- ultrasound
- reflected
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0017—Wound healing
Definitions
- This disclosure relates to the non-invasive application of ultrasonic energy to enhance and/or accelerate the process of wound healing, and more particular, to the healing of wounds including ulcers, such as venous ulcers.
- Venous ulcers on human legs have proven difficult to treat, for example, because of the lack of vascularization in and around the wound.
- wound for the purposes of “wound healing”, as used throughout the present disclosure, includes ulcers such as venous ulcers as well as burns, ulcerated wounds due to, for example, diabetes, surgical incisions or other surgical cuttings including stitched surgical cuttings, skin grafts, hair transplants, revascularization, bed sores, tissue dehiscence, and ligament and tendon repair and reconstruction.
- wound healing encompasses addressing damage to, repair of, or restoration of soft tissue.
- Duarte U.S. Pat. No. 4,530,360 to Duarte (hereafter “Duarte”), describes a basic therapeutic technique and apparatus for applying ultrasonic pulses from an ultrasonic applicator placed on the skin at a location adjacent a bone injury.
- Duarte gives a range of radio frequency (RF) signals for creating the ultrasound, ultrasonic power density levels, a range of duration of each ultrasonic pulse, and a range of ultrasonic pulse frequencies.
- RF radio frequency
- U.S. Pat. Nos. 5,003,965 and 5,186,162 both to Talish and Lifshey (hereafter “Talish '965” and “Talish '162”, respectively) describe an ultrasonic delivery system in which the RF generator and transducer are both part of a modular applicator unit which is placed at the skin location. The signals controlling the duration of ultrasonic pulses and the pulse repetition frequency are generated apart from the applicator unit.
- Talish '965 and Talish '162 also describe fixture apparatus for attaching the applicator unit so that the operative surface is adjacent to the skin location. In one application described in Talish '965 and Talish '162, the skin is surrounded by a cast.
- Talish '160 U.S. Pat. No. 5,211,160 to Talish and Lifshey (hereafter “Talish '160”) also describes a fixture apparatus which is mounted on uncovered body parts; i.e. without a cast or other medical wrapping. Talish '160 also describes various improvements to the applicator unit. Each of Talish '965, Talish '162, and Talish '160 is incorporated herein by reference.
- U.S. patent application Ser. Nos. 08/391,109, 08/388,971, 08/389,148, and 08/367,471 are incorporated herein by reference.
- an ultrasound carrier frequency between 20 kHz and 10 MHz coupled with a relatively low-frequency modulating signal, such as 5 Hz to 10 kHz, and a spatial peak temporal average acoustic intensity, such as an intensity less than about 100 milliwatts/cm 2 , should aid in and should be effective in wound healing.
- both longitudinally propagating ultrasound and shear waves generated by a transducer mechanism and/or by such longitudinally propagating ultrasound provide effective healing of wounds.
- a portable therapeutic device and method of use thereof for healing a wound includes a transducer having an operative surface, with the transducer, disposed substantially adjacent to the wound to emit ultrasound to propagate in the direction of the wound for the healing thereof. Reflections of the ultrasound by bone tissue and by skin layers propagate toward the wound as longitudinal waves for the healing thereof, and shear waves are generated by the longitudinal waves and/or the reflected longitudinal waves for the healing of the wound.
- the transducer may include an axis and a focusing element for focusing the propagation of the ultrasound at a predetermined angle with respect to the axis, with the focused ultrasound propagating toward the wound for the healing thereof.
- Alternative configurations of the operative surface of the transducer include an annularly shaped operative surface for emitting the ultrasound therefrom, with the wound encircled by the operative surface for receiving the ultrasound and/or reflected ultrasound.
- a housing may be provided for positioning the transducer substantially adjacent to a portion of the skin substantially adjacent to the wound, and for causing the portion of the skin to form a cavity, with the operative surface of the transducer disposed in the cavity to emit the ultrasound to an internal surface of the wound for the healing thereof.
- Reflective media may be internally disposed within the body having the wound for reflecting the ultrasound from the transducer to propagate toward the wound for the healing thereof.
- Fixture structures extending about a portion of the body having the wound, may also be provided for positioning the transducer substantially adjacent to the skin substantially adjacent to the wound.
- the fixture structure may include an adjustable strap.
- the transducer may be a rod-shaped operative surface having an axis for emitting the ultrasound radially toward the wound for the healing thereof.
- wounds are safely and simply treated, with such wounds as venous ulcers responsive to therapeutic ultrasound to be healed effectively.
- Such therapeutic devices and methods of use provide for wound treatment by modest adaption of existing devices for delivering ultrasound in therapeutic settings.
- a device for delivering an ultra-high-frequency carrier signal for low power excitation of an acoustic transducer which is acoustically coupled to a limb or other part of a living body.
- the transducer is positioned adjacent an external skin location in the vicinity of the external border of the wound on the skin to provide a surgical, non-invasive transcutaneous delivery of at least part of its acoustic energy directed from the external skin location toward a portion of a bone located within the body in the vicinity of the boundary of the wound internal to the body.
- the boundary of the wound internal to the body is also referred to herein as the internal or interior surface of the wound.
- the acoustic energy Once the acoustic energy enters the body, it passes into internal body tissue and/or fluids.
- the acoustic energy in the form of ultrasonic pulses, is reflected off the surface of underlying bone or other ultrasound reflective material, and the reflected ultrasound travels toward at least part of the internal surface or underside of the wound.
- Healing of the wound at the internal surface by the generation of epithelial cells is enhanced via the acoustic stimulation.
- a low frequency signal which is present as a modulation of the carrier frequency is transmitted from the ultrasonic transducer, through interposed soft tissue, and onto the surface of the bone.
- the carrier wave incident on the bone surface, or other reflection surfaces in the body is reflected toward the internal surface of the wound.
- the carrier wave impinges the internal surface of the wound, at least a portion of the carrier wave is converted into therapeutically beneficial shear waves of acoustic energy, flooding a region of the internal surface of the wound.
- the shear waves increase vascularization at the internal surface of the wound, thus enhancing growth of epithelial cells.
- the epithelial cell growth represents healing of the wound. The technique thus promotes healing of the wound from the internal surface of the wound.
- the number, position, and size of ultrasonic applicators used at the external skin location are chosen based on the size and position of the wound, and the relative position and proximity of the bone from which the ultrasonic waves are reflected.
- FIG. 1 is a cut-away perspective view showing a device and method of use thereof for wound healing
- FIG. 2 is a side view of an embodiment of an ultrasound transducer
- FIG. 3 is a side cross-sectional view of the device using a focusing attachment
- FIG. 3A is a cut-away perspective view of an alternative embodiment of the transducer configured to have an annular shape and a woven fabric covering;
- FIG. 4 is a frontal view of a typical wound disposed on a torso
- FIG. 5 is a cut-away perspective view of the wound healing device disposed near the wound in the torso;
- FIG. 6 is a cut-away perspective view of the wound healing device applied to a wound in conjunction with a gel bladder;
- FIG. 7 is a cut-away perspective view of the wound healing device causing an indentation of the torso to orient the transducer for healing the wound;
- FIG. 8 is a cut-away perspective view of the wound healing device operating in conjunction with an internally disposed reflecting medium
- FIG. 9 is a cut-away perspective view of an alternative configuration of the wound healing device having an annular configuration and a woven fabric covering and operating in conjunction with an internally disposed reflecting medium;
- FIG. 10 is a cut-away perspective view of an alternative configuration of the wound healing device having a rod-like configuration
- FIG. 11 is a cut-away perspective view of an alternative configuration of the wound healing device having an annular configuration without a woven fabric covering.
- FIG. 12 is a perspective view of an alternative configuration of the wound healing device attachable to a thigh for healing a wound thereupon.
- the present disclosure describes an apparatus 10 and method of use thereof for wound healing, which includes an ultrasonic generator 12 and one or more ultrasonic applicators 14 , which include ultrasonic transducers 16 known in the art, for applying ultrasonic waves 18 , 20 to a wound 22 , such as an ulcer. More than one applicator 14 or transducer 16 may be used to stimulate larger wounds, as needed.
- the spatial peak temporal average acoustic intensity of the applicators 14 is between about 5 mW/cm 2 and about 100 mW/cm 2 .
- the carrier frequency and intensity of the ultrasonic treatment is selected by taking into account such factors as: (1) the amount of soft tissue interposed between the external skin location, where the ultrasonic applicator 14 is positioned, (2) the position and cross-section of the bone site 24 from which the ultrasonic waves 18 are reflected, (3) the amount of soft tissue interposed between the bone 26 and the internal surface 28 of the wound 20 , and (4) the size, topography and medical characteristics of the internal surface 28 of the wound 20 , and, consequently, shear waves or surface acoustic waves (SAW) and longitudinal waves to be generated at the site.
- SAW surface acoustic waves
- the carrier wave is modulated with an audio signal approximately between 5 Hz and 10 Khz.
- Low level ultrasound delivers a primary wave called the longitudinal wave 30 , which is emitted by the transducer 16 of the applicator 14 as shown in FIG. 1 .
- the primary longitudinal wave 30 is partially incident on a bone 26 in the body, and so is partially reflected at a reflection site 24 to generate a reflected portion 34 , with the reflected portion 34 directed toward the internal surface 28 of the wound 22 .
- the primary longitudinal wave 30 may also be reflected by other surfaces.
- the internal layer 36 of skin on the opposite side of a limb to the transducer 16 may provide a reflective surface to thus generate additional reflected longitudinal waves 38 directed from the opposite internal skin layer 36 to the wound 22 .
- the ultrasonic applicator 14 including the transducer 16 configured as a modular unit, is placed adjacent an external skin location 40 in the vicinity of the external border of the wound 22 .
- a gel bladder 42 or alternatively a loose conducting gel or other ultrasound conducting media, is positioned between the transducer 16 and the external skin location 40 .
- the ultrasound which is transmitted into the soft tissue medium in the form of longitudinal waves 30 diverges as it moves toward the bone 26 or other surfaces such as the skin layer 36 providing reflection.
- the reflected ultrasound, in the form of longitudinal waves 34 , 38 continues to diverge as it approaches the internal surface 28 of the wound 22 , so that the ultrasonic treatment delivered to the general site of the wound 22 covers a relatively large region of the internal surface 28 of the wound 22 .
- the transducer 16 may have an attachment, typically positioned between the operative surface 46 of the transducer 16 and the gel bladder 42 , which acts as a focusing element to focus the ultrasound emitted from the operative surface 46 into the soft tissue.
- the transducer 16 may be configured to have the focusing element integrally formed with the transducer 16 .
- FIG. 3 shows a side view of the transducer housing of FIG. 2 showing the transducer 16 including the focusing element, illustratively embodied as the attachment 44 .
- the ultrasound emitted from the transducer 16 in the form of a primary longitudinal wave 30 may be directed at an angle 48 with respect to an axis 50 associated with the transducer and thence toward the bone 26 or other reflective surfaces when the ultrasound enters the soft tissue.
- the reflected waves 34 , 38 also remain relatively focused.
- the reflected longitudinal waves 34 , 38 may generate respective sets of shear waves or SAW for providing a combined therapeutic treatment to the wound 22 .
- the reflected longitudinal wave 34 created by reflection of the primary longitudinal wave 30 off the bone 26 is incident on a portion of the internal surface 28 of the wound 22 , thus creating a first set of shear waves 52 .
- the reflected longitudinal wave 38 created by the reflection of the primary longitudinal wave 30 off the opposite side layer 36 of tissue is incident on a separate portion of the wound 22 , thus creating a second set of shear waves 54 .
- the angle 48 of the ultrasonic emission may be swept and/or modified, either physically or electronically, so that different regions of the internal wound surface 28 may be treated.
- two or more transducers may be used, as determined by the size, length, etc. of the wound 22 .
- multiple transducers may be provided at a number of external skin locations around the wound 22 in order to increase the effectiveness of the ultrasonic therapy reflected to the internal surface 28 of the wound 22 .
- the ultrasonic head module of the ultrasonic applicator 14 includes the transducer 16 of an ultrasonic treatment apparatus.
- the fixture structure which holds the head module adjacent the external skin location 40 is omitted.
- the electronics and other features which ultimately provide the excitation signals for the transducer 16 are described in further detail in the above-referenced patents and patent applications, which have been incorporated by reference.
- the at least one ultrasonic applicator 14 may be moved, or may be configured to be movable, to a different external skin location adjacent the wound 22 in order to provide treatment to various portions of the wound 22 . Varying the position of the at least one ultrasonic applicator, including moving the transducer 16 circularly or linearly along the skin, also provides treatment of varying intensity at portions of the wound 22 .
- the transducer 16 itself may also be configured to vibrate with respect to a given external skin location, so that the longitudinal waves 30 generated therefrom and transmitted through the soft tissue are more uniform, thus providing more uniform treatment, including more uniform shear waves, at the internal wound surface 28 where the reflected longitudinal waves 34 , 38 impinge.
- the transducer 16 may be made to vibrate with respect to a housing (not shown in FIGS. 1-3 for clarity) which holds the transducer 16 adjacent an external skin location to accomplish such uniformity of longitudinal waves 30 .
- the focusing of ultrasonic waves described with respect to FIGS. 2-3 above is illustratively shown with a substantially planar operative surface 46 and a substantially conical attachment 44 .
- the focusing of ultrasonic waves may be provided by configuring the transducer 16 with non-planar surfaces such as non-planar operative surfaces or non-planar segments to generate and emit ultrasound with different propagation characteristics in order to allow differing patterns and intensities of ultrasonic waves to be transmitted toward the internal surface 28 of the wound 22 . This provides a variety of therapeutic ultrasonic stimulation and treatment at the internal surface 28 .
- the transducer segments may be pie shaped, annular rings, or other configurations, which may be activated separately or in unison.
- the transducer 16 may be provided with a modal converter or transducer lens, which may also change the pattern of the ultrasound emitted from the transducer 16 .
- the carrier frequency and/or the modulating frequency may also be varied or swept through a range of frequencies in order to provide a variety of treatments to the internal wound surface 28 .
- the frequencies may be varied either in a continuous manner, or discrete changes may be made in the applied frequency. Varying the carrier and/or modulating frequency is especially useful in applying ultrasonic treatment to promote a variety of stages of cell regeneration in approximately the same region during the same therapy session.
- FIG. 3A illustrates treatment of a wound 22 such as a venous ulcer as in FIGS. 1-3 , but utilizing an annular-shaped transducer 56 having a curved operative surface 58 (shown in a cut-away perspective view in FIG. 3A ) composed of a composite piezoelectric material attached by a connector 60 to an ultrasonic generator (not shown in FIG. 3A ), in which the composite piezoelectric material disposed in a woven fabric 62 or a semi-permeable member provides ultrasonic conductivity between the transducer 56 and the skin of the patient.
- the woven fabric 60 may have either a hard or a pliable construction, and may be composed of material conductive of ultrasound. Alternatively, the woven fabric 60 may be porous for retaining and releasing ultrasound conductive gel.
- the transducer 56 is cut or constructed to surround the external surface of the wound 22 .
- the composite piezoelectric material of the transducer 56 emits ultrasonic waves having the therapeutic parameters previously described.
- Primary longitudinal waves 64 , 66 are emitted from the composite piezoelectric material into the body, as shown in FIG. 3A , and reflected from the surface of the bone 26 or from other reflective interfaces, to generate reflected longitudinal waves 68 , 70 , respectively, which are directed onto the internal surface 28 of the wound 22 , thus creating therapeutic shear waves 72 , 74 , respectively.
- the composite piezoelectric material may completely surround the wound 22 ; thus, the primary longitudinal waves 64 , 66 are emitted from around the entire wound, reflected from the reflecting material, and incident on the internal surface 28 of the wound 22 , thereby flooding the internal surface 28 of the wound 22 with the induced shear waves 72 , 74 .
- the present invention also encompasses delivery of ultrasound to the internal surface of the wound where there is no bone or other reflecting surface in the vicinity of the wound, as described below in further detail with reference to FIGS. 4-11 .
- FIG. 4 illustrates the front of a male torso 76 having a wound 78 on the stomach.
- the views illustrated in FIGS. 5-11 are cross-sectional views of FIG. 4 taken across lines 5 - 5 .
- a transducer 80 is positioned in a transducer housing 82 disposed upon the external skin of the torso 76 adjacent to the external border of the wound 78 , and a longitudinal wave 84 emitted from the transducer 80 penetrates far into the body before it is reflected off a surface internal to the torso 76 such as the spine or any internal organs such as the lungs, stomach, or intestines, which may contain gases such as air, with reflected longitudinal waves then directed onto the internal surface 86 of the wound 78 .
- the longitudinal wave 84 may provide some therapeutic healing of the wound 78 , but the intensity of the reflected wave incident on the internal surface 86 of the wound 78 may be too attenuated to provide the necessary therapeutic treatment.
- FIG. 6 shows an alternative method and embodiment of treating such wounds of the torso 76 , in which a gel bladder 88 is interposed between the external surface of the wound 78 and the operative surface of the transducer 80 .
- the longitudinal wave 84 emitted from the transducer 80 travels directly through the gel bladder 88 and into the wound 78 , thus creating a shear wave 90 when the longitudinal wave 84 is incident on the internal surface of the wound 78 .
- the gel bladder 88 is to be sterile, especially if the wound 78 is open, and may be impregnated with medication, such as an antibacterial ointment, which flows into the wound 78 and/or its surface during the ultrasonic treatment.
- FIG. 7 illustrates another method and device for treating the wound 78 of a torso 76 , in which the transducer 80 is pressed against the external surface of the lower torso, such as approximately adjacent the stomach, to be positioned near the wound 78 .
- the transducer housing 82 By pressing the transducer housing 82 against the external region of the stomach, a local indentation 92 is created.
- the transducer housing 82 may be turned as it is pressed inward, so that the operative surface 94 of the transducer 80 is directed in the general direction toward the internal surface 96 of the wound 78 within the indentation 92 .
- the longitudinal wave 98 emitted is incident directly on at least a portion of the internal surface 96 of the wound 78 , thus inducing therapeutic shear waves 100 .
- a specially configured transducer, or alternatively a transducer attachment 102 is used, such as shown in FIG. 3 , for focusing the ultrasound in a specific direction
- the longitudinal wave 98 may be emitted off of a center axis 104 of the transducer 80 , for example, in a direction toward the internal surface 96 of the wound 78 , without the need for turning the transducer housing 82 as it is pressed against the skin.
- FIG. 8 illustrates another method and device for treating a wound 78 , in which a reflecting medium 106 is inserted into the body in the proximity of the internal surface 96 of the wound 78 .
- the properties of the reflecting medium 106 provide for the reflection of the longitudinal wave 108 toward the internal surface 96 of the wound 96 , as if a bone were present, such as described above with reference to FIGS. 1-3A .
- the reflecting medium 106 may be composed of a variety of materials, and may be fixed in the body or inserted temporarily.
- the reflecting medium 106 may be a metallic plate, a gas filled pouch, or other quasi-permanent inserts.
- the reflecting medium 106 may be also be, for example, a contrast agent composed of, for example, bubbles in a gelatin, which is injected intravenously prior to the treatment.
- the contrast agent may be absorbable by the body in a relatively short period, thus the contrast agent acts as a temporarily inserted reflecting medium.
- An inserted reflecting medium 106 performs particularly well in conjunction with a piezoelectric ultrasonic material or device.
- the piezoelectric ultrasonic device 110 may be embodied as the device 56 described above with respect to FIG. 3A .
- the piezoelectric ultrasonic device 110 may be configured to surround the exterior boundary of the wound 78 .
- illustrative examples of the longitudinal waves 112 , 114 generated from the piezoelectric ultrasonic device 110 surrounding the wound 78 are reflected off of an internally disposed medium 116 and onto the internal surface 96 of the wound 78 , thereby generating therapeutic shear waves (not shown in FIG.
- an ultrasonic transmitting rod 118 which emits at least one longitudinal wave 120 radially from the axis of the ultrasonic transmitting rod 118 .
- the rod 118 may be composed of, for example, a composite piezoelectric material, and the rod 118 is secured to the patient by a harness apparatus 122 , 124 such that the rod 118 is pressed against the skin adjacent the wound 10 , and a portion of the longitudinal wave 120 is incident on the internal surface 96 of the wound 78 , thus inducing therapeutic shear waves (not shown in FIG. 10 ).
- an ultrasonic transmitting ring 126 which emits longitudinal waves 128 , 130 radially from the surface of the ring 126 .
- the ring may be composed of, for example, a composite piezoelectric material, and may be configured in a manner similar to the piezoelectric ultrasonic devices 56 and 110 in FIGS. 3A and 9 , respectively, without the woven fabric to act as an ultrasonic conductor. Accordingly, ultrasonic conductive gel may be used with the ring 126 of FIG. 11 .
- the ring 126 may be configured to completely surrounds the wound 78 ; thus, longitudinal waves including the illustrative longitudinal waves 128 , 130 are emitted from around the entire wound 78 and incident on the internal surface 96 of the wound 78 , to flood the internal surface 96 of the wound 78 with induced shear waves 132 , 134 .
- the wound healing device 136 includes a transducer 138 positioned in a housing 140 which is secured by an adjustable securing structure 142 to a thigh for healing a wound 78 thereupon, with the transducer 138 emitting longitudinal ultrasonic waves 144 which generate shear waves (not shown in FIG. 12 ) upon contact with the internal surface of the wound 78 .
- the adjustable securing structure 142 shown in FIG. 12 includes an adjustable strap 146 having a first portion 148 engaging a second portion 150 using hook and link fasteners, such as “VELCRO”.
- a belt with a buckle and notches may be used, or a sterile adhesive strip for adhering to the thigh.
- wound has a broad meaning, generally encompassing addressing damage to, repair of, or restoration of soft tissue.
- the present invention may be used, for example, to prevent surgical adhesions, by stimulating the proper repair of surgical incisions. It may also prevent or arrest wound dehiscence, by promoting vascularization at the surfaces adjacent surgical incisions. It may also be used in cosmetic surgery, for example, by enhancing the healing of hair transplants, or by directly stimulating regeneration of cells.
Abstract
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Claims (11)
Priority Applications (1)
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US09/928,594 US7628764B2 (en) | 1997-02-14 | 2001-08-13 | Ultrasonic treatment for wounds |
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US08/886,217 US5904659A (en) | 1997-02-14 | 1997-07-01 | Ultrasonic treatment for wounds |
US09/273,221 US6273864B1 (en) | 1997-02-14 | 1999-03-19 | Ultrasonic treatment for wounds |
US09/928,594 US7628764B2 (en) | 1997-02-14 | 2001-08-13 | Ultrasonic treatment for wounds |
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US09/273,214 Continuation US6190336B1 (en) | 1997-02-14 | 1999-03-19 | Ultrasonic treatment for wounds |
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---|---|---|---|---|
US7189209B1 (en) | 1996-03-29 | 2007-03-13 | Sanuwave, Inc. | Method for using acoustic shock waves in the treatment of a diabetic foot ulcer or a pressure sore |
GB9617749D0 (en) * | 1996-08-23 | 1996-10-02 | Young Michael J R | Improved apparatus for ultrasonic therapeutic trteatment |
US7789841B2 (en) * | 1997-02-06 | 2010-09-07 | Exogen, Inc. | Method and apparatus for connective tissue treatment |
US7108663B2 (en) * | 1997-02-06 | 2006-09-19 | Exogen, Inc. | Method and apparatus for cartilage growth stimulation |
US6390995B1 (en) | 1997-02-12 | 2002-05-21 | Healthtronics Surgical Services, Inc. | Method for using acoustic shock waves in the treatment of medical conditions |
US6368292B1 (en) * | 1997-02-12 | 2002-04-09 | Healthtronics Inc. | Method for using acoustic shock waves in the treatment of medical conditions |
US5904659A (en) * | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
CA2285595A1 (en) * | 1997-04-18 | 1998-10-29 | Exogen, Inc. | Ultrasound application device for accelerating sternum healing |
US6050943A (en) | 1997-10-14 | 2000-04-18 | Guided Therapy Systems, Inc. | Imaging, therapy, and temperature monitoring ultrasonic system |
US6165144A (en) * | 1998-03-17 | 2000-12-26 | Exogen, Inc. | Apparatus and method for mounting an ultrasound transducer |
DE69933555T2 (en) * | 1998-05-06 | 2007-06-14 | Exogen, Inc., Memphis | ULTRASOUND SUPPORTS |
WO2000004831A1 (en) | 1998-07-21 | 2000-02-03 | Acoustic Sciences Associates | Synthetic structural imaging and volume estimation of biological tissue organs |
BR9913559A (en) * | 1998-09-11 | 2001-06-05 | Berkshire Lab Inc | Methods for using resonant acoustic energy and / or resonant acousto-em to detect and / or effect structures |
US7686763B2 (en) * | 1998-09-18 | 2010-03-30 | University Of Washington | Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy |
US7722539B2 (en) * | 1998-09-18 | 2010-05-25 | University Of Washington | Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue |
US7211054B1 (en) * | 1998-11-06 | 2007-05-01 | University Of Rochester | Method of treating a patient with a neurodegenerative disease using ultrasound |
US6283956B1 (en) | 1998-11-30 | 2001-09-04 | David H. McDaniels | Reduction, elimination, or stimulation of hair growth |
US9192780B2 (en) * | 1998-11-30 | 2015-11-24 | L'oreal | Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders |
US20060212025A1 (en) | 1998-11-30 | 2006-09-21 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6755796B2 (en) | 1999-02-07 | 2004-06-29 | Medispec Ltd. | Pressure-pulse therapy apparatus |
IL128404A0 (en) * | 1999-02-07 | 2000-01-31 | Spector Avner | Device for transmission of shock waves on to large surfaces of human tissue |
US6406443B1 (en) * | 1999-06-14 | 2002-06-18 | Exogen, Inc. | Self-contained ultrasound applicator |
IL131623A0 (en) * | 1999-08-27 | 2001-01-28 | Dan Weiss | Apparatus to couple ultrasonic energy to catheters and other transdermal medical devices |
US7510536B2 (en) | 1999-09-17 | 2009-03-31 | University Of Washington | Ultrasound guided high intensity focused ultrasound treatment of nerves |
US20050240170A1 (en) * | 1999-10-25 | 2005-10-27 | Therus Corporation | Insertable ultrasound probes, systems, and methods for thermal therapy |
AU2598201A (en) * | 1999-12-23 | 2001-07-03 | Therus Corporation | Ultrasound transducers for imaging and therapy |
US6733450B1 (en) | 2000-07-27 | 2004-05-11 | Texas Systems, Board Of Regents | Therapeutic methods and apparatus for use of sonication to enhance perfusion of tissue |
CA2421005A1 (en) * | 2000-08-24 | 2002-02-28 | Timi 3 Systems, Inc. | Systems and method for applying ultrasonic energy |
US7335169B2 (en) * | 2000-08-24 | 2008-02-26 | Timi 3 Systems, Inc. | Systems and methods for delivering ultrasound energy at an output power level that remains essentially constant despite variations in transducer impedance |
US20030069526A1 (en) * | 2000-08-24 | 2003-04-10 | Timi 3 Systems, Inc. | Applicators that house and support ultrasound transducers for transcutaneous delivery of ultrasound energy |
US20020082529A1 (en) * | 2000-08-24 | 2002-06-27 | Timi 3 Systems, Inc. | Systems and methods for applying pulsed ultrasonic energy |
US20020091339A1 (en) * | 2000-08-24 | 2002-07-11 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasound energy to stimulating circulatory activity in a targeted body region of an individual |
US7241270B2 (en) * | 2000-08-24 | 2007-07-10 | Timi 3 Systems Inc. | Systems and methods for monitoring and enabling use of a medical instrument |
US20020072690A1 (en) * | 2000-08-24 | 2002-06-13 | Timi 3 | Transportable systems for applying ultrasound energy to the thoracic cavity |
US6790187B2 (en) * | 2000-08-24 | 2004-09-14 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasonic energy |
US20020072691A1 (en) * | 2000-08-24 | 2002-06-13 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasonic energy to the thoracic cavity |
US7220232B2 (en) * | 2000-08-24 | 2007-05-22 | Timi 3 Systems, Inc. | Method for delivering ultrasonic energy |
US6964647B1 (en) * | 2000-10-06 | 2005-11-15 | Ellaz Babaev | Nozzle for ultrasound wound treatment |
NO315547B1 (en) * | 2000-10-16 | 2003-09-22 | Meditron Asa | Medical patch |
US6932308B2 (en) * | 2000-10-25 | 2005-08-23 | Exogen, Inc. | Transducer mounting assembly |
US6601581B1 (en) | 2000-11-01 | 2003-08-05 | Advanced Medical Applications, Inc. | Method and device for ultrasound drug delivery |
US6533803B2 (en) | 2000-12-22 | 2003-03-18 | Advanced Medical Applications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US6761729B2 (en) | 2000-12-22 | 2004-07-13 | Advanced Medicalapplications, Inc. | Wound treatment method and device with combination of ultrasound and laser energy |
US7914453B2 (en) | 2000-12-28 | 2011-03-29 | Ardent Sound, Inc. | Visual imaging system for ultrasonic probe |
US7914470B2 (en) | 2001-01-12 | 2011-03-29 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US8235919B2 (en) * | 2001-01-12 | 2012-08-07 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
US6960173B2 (en) * | 2001-01-30 | 2005-11-01 | Eilaz Babaev | Ultrasound wound treatment method and device using standing waves |
US6623444B2 (en) | 2001-03-21 | 2003-09-23 | Advanced Medical Applications, Inc. | Ultrasonic catheter drug delivery method and device |
US6478754B1 (en) | 2001-04-23 | 2002-11-12 | Advanced Medical Applications, Inc. | Ultrasonic method and device for wound treatment |
AU2002315027A1 (en) * | 2001-05-15 | 2002-11-25 | Children's Medical Center Corporation | Methods and apparatus for application of micro-mechanical forces to tissues |
JP4660024B2 (en) * | 2001-06-26 | 2011-03-30 | 帝人株式会社 | MMP activity lowering apparatus and method |
US6770042B2 (en) * | 2001-10-01 | 2004-08-03 | Richard H. Lee | Therapeutic signal combination |
US7780785B2 (en) * | 2001-10-26 | 2010-08-24 | Applied Materials, Inc. | Gas delivery apparatus for atomic layer deposition |
WO2003061492A1 (en) * | 2002-01-18 | 2003-07-31 | Teijin Limited | Method of treating osteochondritis and apparatus for treating osteochondritis |
IL148791A0 (en) * | 2002-03-20 | 2002-09-12 | Yoni Iger | Method and apparatus for altering activity of tissue layers |
US6792313B2 (en) | 2002-03-29 | 2004-09-14 | Stimu-Heal Inc | Muscle stimulation in a cast immobilized limo |
US7829029B2 (en) | 2002-05-29 | 2010-11-09 | NanoVibronix, Inv. | Acoustic add-on device for biofilm prevention in urinary catheter |
US7393501B2 (en) * | 2002-05-29 | 2008-07-01 | Nano Vibronix Inc | Method, apparatus and system for treating biofilms associated with catheters |
JP4243499B2 (en) * | 2002-06-11 | 2009-03-25 | 富士通株式会社 | Bonded substrate manufacturing apparatus and bonded substrate manufacturing method |
AU2009210402A1 (en) * | 2002-07-24 | 2009-09-10 | Timi 3 Systems, Inc. | Systems and methods for monitoring and enabling use of a medical instrument |
US7229423B2 (en) * | 2003-02-05 | 2007-06-12 | Timi 3 System, Inc | Systems and methods for applying audible acoustic energy to increase tissue perfusion and/or vasodilation |
US20040064051A1 (en) * | 2002-09-30 | 2004-04-01 | Talish Roger J. | Ultrasound transducer coupling apparatus |
GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
FR2850265B1 (en) * | 2003-01-23 | 2005-11-18 | Oreal | SKIN ANALYSIS DEVICE HAVING AN ULTRASONIC PROBE |
US7901355B2 (en) * | 2003-01-23 | 2011-03-08 | L'oreal | Skin analysis apparatus including an ultrasound probe |
US20080208084A1 (en) * | 2003-02-05 | 2008-08-28 | Timi 3 Systems, Inc. | Systems and methods for applying ultrasound energy to increase tissue perfusion and/or vasodilation without substantial deep heating of tissue |
KR20060041161A (en) * | 2003-04-10 | 2006-05-11 | 라이트 바이오사이언스, 엘엘씨 | Photomodulation methods and devices for regulating cell proliferation and gene expression |
US7175599B2 (en) * | 2003-04-17 | 2007-02-13 | Brigham And Women's Hospital, Inc. | Shear mode diagnostic ultrasound |
US7344509B2 (en) * | 2003-04-17 | 2008-03-18 | Kullervo Hynynen | Shear mode therapeutic ultrasound |
US20050070961A1 (en) * | 2003-07-15 | 2005-03-31 | Terumo Kabushiki Kaisha | Energy treatment apparatus |
CA2533129A1 (en) | 2003-07-31 | 2005-02-10 | Light Bioscience, Llc | System and method for the photodynamic treatment of burns, wounds, and related skin disorders |
US8870796B2 (en) | 2003-09-04 | 2014-10-28 | Ahof Biophysical Systems Inc. | Vibration method for clearing acute arterial thrombotic occlusions in the emergency treatment of heart attack and stroke |
US8734368B2 (en) * | 2003-09-04 | 2014-05-27 | Simon Fraser University | Percussion assisted angiogenesis |
CA2439667A1 (en) * | 2003-09-04 | 2005-03-04 | Andrew Kenneth Hoffmann | Low frequency vibration assisted blood perfusion system and apparatus |
US8721573B2 (en) | 2003-09-04 | 2014-05-13 | Simon Fraser University | Automatically adjusting contact node for multiple rib space engagement |
US8321278B2 (en) * | 2003-09-30 | 2012-11-27 | Google Inc. | Targeted advertisements based on user profiles and page profile |
GB0325126D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with heat |
GB0325130D0 (en) * | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus with scaffold |
JP2007519504A (en) * | 2004-02-02 | 2007-07-19 | サヌウェーブ,インク. | Use of an extracorporeal shock wave applicator |
US7909805B2 (en) | 2004-04-05 | 2011-03-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US8062272B2 (en) | 2004-05-21 | 2011-11-22 | Bluesky Medical Group Incorporated | Flexible reduced pressure treatment appliance |
US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
GB0409292D0 (en) | 2004-04-27 | 2004-06-02 | Smith & Nephew | Apparatus with ultrasound |
US8235909B2 (en) | 2004-05-12 | 2012-08-07 | Guided Therapy Systems, L.L.C. | Method and system for controlled scanning, imaging and/or therapy |
EP1751807A4 (en) * | 2004-05-18 | 2011-10-19 | Nanovibronix Inc | Nanovibration coating process for medical devices using multi vibration modes of a thin piezo element |
US20060022504A1 (en) * | 2004-07-26 | 2006-02-02 | Johnson Timothy A | Air fluidized granular wound care wheelchair overlay |
US20060047230A1 (en) * | 2004-08-18 | 2006-03-02 | Roger Talish | Non-invasive apparatus and method for vibrational treatment of internal organs |
US8409099B2 (en) * | 2004-08-26 | 2013-04-02 | Insightec Ltd. | Focused ultrasound system for surrounding a body tissue mass and treatment method |
AU2005205820B2 (en) * | 2004-09-04 | 2011-04-14 | Smith & Nephew Plc | Ultrasound device and method of use |
US7080420B2 (en) * | 2004-09-16 | 2006-07-25 | Scott Damron | Adjustable head-support for therapy tables |
US7824348B2 (en) | 2004-09-16 | 2010-11-02 | Guided Therapy Systems, L.L.C. | System and method for variable depth ultrasound treatment |
US7393325B2 (en) | 2004-09-16 | 2008-07-01 | Guided Therapy Systems, L.L.C. | Method and system for ultrasound treatment with a multi-directional transducer |
US9011336B2 (en) | 2004-09-16 | 2015-04-21 | Guided Therapy Systems, Llc | Method and system for combined energy therapy profile |
AU2005284695A1 (en) * | 2004-09-16 | 2006-03-23 | University Of Washington | Acoustic coupler using an independent water pillow with circulation for cooling a transducer |
US7530958B2 (en) * | 2004-09-24 | 2009-05-12 | Guided Therapy Systems, Inc. | Method and system for combined ultrasound treatment |
US8535228B2 (en) | 2004-10-06 | 2013-09-17 | Guided Therapy Systems, Llc | Method and system for noninvasive face lifts and deep tissue tightening |
US10864385B2 (en) | 2004-09-24 | 2020-12-15 | Guided Therapy Systems, Llc | Rejuvenating skin by heating tissue for cosmetic treatment of the face and body |
US8444562B2 (en) | 2004-10-06 | 2013-05-21 | Guided Therapy Systems, Llc | System and method for treating muscle, tendon, ligament and cartilage tissue |
US11235179B2 (en) | 2004-10-06 | 2022-02-01 | Guided Therapy Systems, Llc | Energy based skin gland treatment |
US9694212B2 (en) | 2004-10-06 | 2017-07-04 | Guided Therapy Systems, Llc | Method and system for ultrasound treatment of skin |
JP2008522642A (en) | 2004-10-06 | 2008-07-03 | ガイデッド セラピー システムズ, エル.エル.シー. | Method and system for beauty enhancement |
EP3682946A1 (en) | 2004-10-06 | 2020-07-22 | Guided Therapy Systems, L.L.C. | System for noninvasive tissue treatment |
US8690778B2 (en) | 2004-10-06 | 2014-04-08 | Guided Therapy Systems, Llc | Energy-based tissue tightening |
US11883688B2 (en) | 2004-10-06 | 2024-01-30 | Guided Therapy Systems, Llc | Energy based fat reduction |
US7530356B2 (en) * | 2004-10-06 | 2009-05-12 | Guided Therapy Systems, Inc. | Method and system for noninvasive mastopexy |
US8133180B2 (en) | 2004-10-06 | 2012-03-13 | Guided Therapy Systems, L.L.C. | Method and system for treating cellulite |
US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
US20060111744A1 (en) | 2004-10-13 | 2006-05-25 | Guided Therapy Systems, L.L.C. | Method and system for treatment of sweat glands |
US7758524B2 (en) | 2004-10-06 | 2010-07-20 | Guided Therapy Systems, L.L.C. | Method and system for ultra-high frequency ultrasound treatment |
US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
US11207548B2 (en) | 2004-10-07 | 2021-12-28 | Guided Therapy Systems, L.L.C. | Ultrasound probe for treating skin laxity |
US7578796B2 (en) * | 2004-10-22 | 2009-08-25 | General Patent Llc | Method of shockwave treating fish and shellfish |
US7601127B2 (en) * | 2004-10-22 | 2009-10-13 | General Patent, Llc | Therapeutic stimulation of genital tissue or reproductive organ of an infertility or impotence diagnosed patient |
US20060111652A1 (en) * | 2004-11-22 | 2006-05-25 | Mcleod Kenneth J | Method for enhancing blood and lymph flow in the extremities |
US8603017B2 (en) | 2005-03-07 | 2013-12-10 | American Medical Innovations, L.L.C. | Vibrational therapy assembly for treating and preventing the onset of deep venous thrombosis |
GB0508254D0 (en) * | 2005-04-23 | 2005-06-01 | Smith & Nephew | Ultrasound device |
EP1875327A2 (en) | 2005-04-25 | 2008-01-09 | Guided Therapy Systems, L.L.C. | Method and system for enhancing computer peripheral saftey |
US7713218B2 (en) * | 2005-06-23 | 2010-05-11 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US7785277B2 (en) * | 2005-06-23 | 2010-08-31 | Celleration, Inc. | Removable applicator nozzle for ultrasound wound therapy device |
US20070129652A1 (en) * | 2005-11-15 | 2007-06-07 | Henry Nita | Methods and apparatus for intracranial ultrasound therapies |
US9274099B2 (en) | 2005-07-22 | 2016-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Screening test drugs to identify their effects on cell membrane voltage-gated ion channel |
US9238150B2 (en) | 2005-07-22 | 2016-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Optical tissue interface method and apparatus for stimulating cells |
US10052497B2 (en) * | 2005-07-22 | 2018-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
US8926959B2 (en) | 2005-07-22 | 2015-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
EP2465925A1 (en) | 2005-07-22 | 2012-06-20 | The Board Of Trustees Of The Leland | Light-activated cation channel and uses thereof |
EP1747818A3 (en) * | 2005-07-27 | 2009-07-22 | Wellcomet GmbH | System and method for generating ultrasonic waves |
US7591996B2 (en) * | 2005-08-17 | 2009-09-22 | University Of Washington | Ultrasound target vessel occlusion using microbubbles |
WO2007035529A2 (en) * | 2005-09-16 | 2007-03-29 | University Of Washington | Thin-profile therapeutic ultrasound applicators |
JP5087007B2 (en) * | 2005-11-23 | 2012-11-28 | インサイテック・リミテッド | Hierarchical switching ultra high density ultrasonic array |
US20070149881A1 (en) * | 2005-12-22 | 2007-06-28 | Rabin Barry H | Ultrasonically Powered Medical Devices and Systems, and Methods and Uses Thereof |
WO2007073214A1 (en) * | 2005-12-22 | 2007-06-28 | Donald Michael Graham | A transducer interface system |
CA2633910C (en) † | 2006-01-23 | 2012-07-03 | Kci Licensing, Inc. | System and method for treating a wound using ultrasonic debridement |
WO2007103415A2 (en) * | 2006-03-08 | 2007-09-13 | Juvent, Inc. | System and method for providing therapeutic treatment using a combination of ultrasound, electro-stimulation and vibrational stimulation |
CN101616707B (en) * | 2006-03-29 | 2013-01-02 | 纳微振动技术公司 | An acoustic add-on device for biofilm prevention in urinary catheter |
US20070249938A1 (en) * | 2006-04-20 | 2007-10-25 | Donald J. Shields | Systems, devices, and methods employing therapeutic ultrasound of living tissues |
US8128568B2 (en) * | 2006-05-02 | 2012-03-06 | U-Systems, Inc. | Handheld volumetric ultrasound scanning device |
US20070282221A1 (en) * | 2006-06-02 | 2007-12-06 | U-Systems, Inc. | Ultrasound assisted and x-ray assisted biopsy devices |
US20130165824A1 (en) * | 2006-05-17 | 2013-06-27 | The Research Foundation Of The State University Of New York | Method and system for physical stimulation of tissue |
US8562547B2 (en) | 2006-06-07 | 2013-10-22 | Eliaz Babaev | Method for debriding wounds |
US7431704B2 (en) * | 2006-06-07 | 2008-10-07 | Bacoustics, Llc | Apparatus and method for the treatment of tissue with ultrasound energy by direct contact |
WO2008008340A2 (en) * | 2006-07-11 | 2008-01-17 | Juvent, Inc. | System and method for a low profile vibrating plate |
US20100030076A1 (en) * | 2006-08-01 | 2010-02-04 | Kobi Vortman | Systems and Methods for Simultaneously Treating Multiple Target Sites |
CN101522263A (en) * | 2006-08-25 | 2009-09-02 | 艾拉兹·巴巴耶夫 | Portable ultrasound device for the treatment of wounds |
US9566454B2 (en) | 2006-09-18 | 2017-02-14 | Guided Therapy Systems, Llc | Method and sysem for non-ablative acne treatment and prevention |
US9241683B2 (en) | 2006-10-04 | 2016-01-26 | Ardent Sound Inc. | Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid |
US20080139977A1 (en) * | 2006-12-07 | 2008-06-12 | Juvent. Inc. | Non-invasive methods for vibrational treatment of bone tissue following a bone-related medical procedure |
US9050448B2 (en) * | 2006-12-19 | 2015-06-09 | Cedars-Sinai Medical Center | Ultrasonic bath to increase tissue perfusion |
US20080177221A1 (en) * | 2006-12-22 | 2008-07-24 | Celleration, Inc. | Apparatus to prevent applicator re-use |
US20100094179A1 (en) * | 2006-12-22 | 2010-04-15 | Smith & Nephew Inc | Optimized Diffraction Zone for Ultrasound Therapy |
US20080214965A1 (en) * | 2007-01-04 | 2008-09-04 | Celleration, Inc. | Removable multi-channel applicator nozzle |
US8491521B2 (en) | 2007-01-04 | 2013-07-23 | Celleration, Inc. | Removable multi-channel applicator nozzle |
US8398692B2 (en) * | 2007-01-10 | 2013-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | System for optical stimulation of target cells |
WO2008101128A1 (en) | 2007-02-14 | 2008-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | System, method and applications involving identification of biological circuits such as neurological characteristics |
WO2008106694A2 (en) | 2007-03-01 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Systems, methods and compositions for optical stimulation of target cells |
US8088084B2 (en) * | 2007-03-06 | 2012-01-03 | The Cleveland Clinic Foundation | Method and apparatus for repair of intervertebral discs |
PT2644205T (en) | 2007-04-12 | 2018-10-19 | Brigham & Womens Hospital Inc | Targeting abcb5 for cancer therapy |
US8057446B2 (en) * | 2007-05-01 | 2011-11-15 | The Brigham And Women's Hospital, Inc. | Wound healing device |
JP2010526589A (en) | 2007-05-07 | 2010-08-05 | ガイデッド セラピー システムズ, エル.エル.シー. | Method and system for modulating a mediant using acoustic energy |
US20150174388A1 (en) | 2007-05-07 | 2015-06-25 | Guided Therapy Systems, Llc | Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue |
US8764687B2 (en) | 2007-05-07 | 2014-07-01 | Guided Therapy Systems, Llc | Methods and systems for coupling and focusing acoustic energy using a coupler member |
US20090082703A1 (en) * | 2007-09-26 | 2009-03-26 | Robert Muratore | Method and apparatus for the treatment of tendon abnormalities |
JP2009088246A (en) * | 2007-09-28 | 2009-04-23 | Canon Inc | Exposure device and device manufacturing method |
US10434327B2 (en) | 2007-10-31 | 2019-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Implantable optical stimulators |
US10035027B2 (en) | 2007-10-31 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Device and method for ultrasonic neuromodulation via stereotactic frame based technique |
HUE041864T2 (en) | 2007-11-21 | 2019-06-28 | Smith & Nephew | Wound dressing |
EP2231230A4 (en) | 2007-12-21 | 2013-01-23 | Carticept Medical Inc | Articular injection system |
US8545440B2 (en) | 2007-12-21 | 2013-10-01 | Carticept Medical, Inc. | Injection system for delivering multiple fluids within the anatomy |
US9044542B2 (en) | 2007-12-21 | 2015-06-02 | Carticept Medical, Inc. | Imaging-guided anesthesia injection systems and methods |
EP2231279A1 (en) * | 2007-12-28 | 2010-09-29 | Celleration, Inc. | Methods for treating inflammatory skin disorders |
US20090177123A1 (en) * | 2007-12-28 | 2009-07-09 | Celleration, Inc. | Methods for treating inflammatory disorders |
US7866527B2 (en) | 2008-02-14 | 2011-01-11 | Ethicon Endo-Surgery, Inc. | Surgical stapling apparatus with interlockable firing system |
EP2092916A1 (en) * | 2008-02-19 | 2009-08-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | A method of treating an ocular pathology by applying high intensity focused ultrasound and device thereof |
US8206326B2 (en) | 2008-03-04 | 2012-06-26 | Sound Surgical Technologies, Llc | Combination ultrasound-phototherapy transducer |
US9020576B2 (en) * | 2008-03-31 | 2015-04-28 | Okayama Prefecture | Biological measurement apparatus and biological stimulation apparatus |
US20090254005A1 (en) * | 2008-04-03 | 2009-10-08 | Eilaz Babaev | Ultrasound assisted tissue welding device |
WO2009131837A2 (en) | 2008-04-23 | 2009-10-29 | The Board Of Trustees Of The Leland Stanford Junior University. | Systems, methods and compositions for optical stimulation of target cells |
AU2009256457B2 (en) | 2008-05-29 | 2014-06-26 | The Board Of Trustees Of The Leland Stanford Junior University | Cell line, system and method for optical control of secondary messengers |
KR102479936B1 (en) | 2008-06-06 | 2022-12-22 | 얼테라, 인크 | Ultrasound treatment system |
SG191593A1 (en) | 2008-06-17 | 2013-07-31 | Univ Leland Stanford Junior | Methods, systems and devices for optical stimulation of target cells using an optical transmission element |
BRPI0915583A2 (en) * | 2008-06-17 | 2016-01-26 | Univ Leland Stanford Junior | apparatus and methods for controlling cell development |
US9101759B2 (en) | 2008-07-08 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Materials and approaches for optical stimulation of the peripheral nervous system |
US20100022919A1 (en) * | 2008-07-22 | 2010-01-28 | Celleration, Inc. | Methods of Skin Grafting Using Ultrasound |
JP2012507365A (en) * | 2008-10-30 | 2012-03-29 | スミス アンド ネフュー インコーポレーテッド | Apparatus and method for ultrasonic treatment of the spine |
NZ602416A (en) | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
US8425424B2 (en) * | 2008-11-19 | 2013-04-23 | Inightee Ltd. | Closed-loop clot lysis |
WO2010075547A2 (en) | 2008-12-24 | 2010-07-01 | Guided Therapy Systems, Llc | Methods and systems for fat reduction and/or cellulite treatment |
EP2398432B1 (en) | 2009-02-18 | 2017-09-06 | Eye Tech Care | Ultrasound device comprising means to generate ultrasound beam presenting a concave segment shape having a single curvature |
US8617073B2 (en) * | 2009-04-17 | 2013-12-31 | Insightec Ltd. | Focusing ultrasound into the brain through the skull by utilizing both longitudinal and shear waves |
US9177543B2 (en) * | 2009-08-26 | 2015-11-03 | Insightec Ltd. | Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI |
WO2011045669A2 (en) * | 2009-10-14 | 2011-04-21 | Insightec Ltd. | Mapping ultrasound transducers |
US8715186B2 (en) | 2009-11-24 | 2014-05-06 | Guided Therapy Systems, Llc | Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy |
WO2011082407A2 (en) | 2009-12-31 | 2011-07-07 | Zetroz Llc | Portable ultrasound system |
CN106011073A (en) | 2010-03-17 | 2016-10-12 | 小利兰·斯坦福大学托管委员会 | Light-sensitive ion-passing molecules |
US9852727B2 (en) | 2010-04-28 | 2017-12-26 | Insightec, Ltd. | Multi-segment ultrasound transducers |
US8932237B2 (en) | 2010-04-28 | 2015-01-13 | Insightec, Ltd. | Efficient ultrasound focusing |
US9504446B2 (en) | 2010-08-02 | 2016-11-29 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
US9149658B2 (en) | 2010-08-02 | 2015-10-06 | Guided Therapy Systems, Llc | Systems and methods for ultrasound treatment |
US10029089B2 (en) | 2010-10-15 | 2018-07-24 | Research Foundation For The State University Of New York, The | Compositions and methods for enhancing the biological response to chemical agents and physical stimuli |
CA2816976C (en) | 2010-11-05 | 2019-12-03 | The Board Of Trustees Of The Leland Standford Junior University | Optogenetic control of reward-related behaviors |
US9522288B2 (en) | 2010-11-05 | 2016-12-20 | The Board Of Trustees Of The Leland Stanford Junior University | Upconversion of light for use in optogenetic methods |
WO2012061744A2 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Stabilized step function opsin proteins and methods of using the same |
WO2012061679A2 (en) | 2010-11-05 | 2012-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated chimeric opsins and methods of using the same |
JP6328424B6 (en) | 2010-11-05 | 2018-07-11 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Control and characterization of memory functions |
CA2816968C (en) | 2010-11-05 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Optically-controlled cns dysfunction |
US8857438B2 (en) | 2010-11-08 | 2014-10-14 | Ulthera, Inc. | Devices and methods for acoustic shielding |
US8696722B2 (en) | 2010-11-22 | 2014-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic magnetic resonance imaging |
WO2013009784A2 (en) | 2011-07-10 | 2013-01-17 | Guided Therapy Systems, Llc | Systems and method for accelerating healing of implanted material and/or native tissue |
WO2013012641A1 (en) | 2011-07-11 | 2013-01-24 | Guided Therapy Systems, Llc | Systems and methods for coupling an ultrasound source to tissue |
WO2013040688A1 (en) * | 2011-09-21 | 2013-03-28 | Intelligent Nano Inc | Enhancement of eukaryotic cell properties using ultrasound |
JP6406581B2 (en) | 2011-12-16 | 2018-10-17 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Opsin polypeptides and uses thereof |
JP6537826B2 (en) | 2012-02-21 | 2019-07-03 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Compositions and methods for treating pelvic floor neurological disorders |
US9263663B2 (en) | 2012-04-13 | 2016-02-16 | Ardent Sound, Inc. | Method of making thick film transducer arrays |
US9510802B2 (en) | 2012-09-21 | 2016-12-06 | Guided Therapy Systems, Llc | Reflective ultrasound technology for dermatological treatments |
EP2961349A1 (en) * | 2013-02-28 | 2016-01-06 | Boston Scientific Scimed, Inc. | Stent with balloon for repair of anastomosis surgery leaks |
CN204637350U (en) | 2013-03-08 | 2015-09-16 | 奥赛拉公司 | Aesthstic imaging and processing system, multifocal processing system and perform the system of aesthetic procedure |
US10561862B2 (en) | 2013-03-15 | 2020-02-18 | Guided Therapy Systems, Llc | Ultrasound treatment device and methods of use |
US9636380B2 (en) | 2013-03-15 | 2017-05-02 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of inputs to the ventral tegmental area |
CA2906756A1 (en) | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Optogenetic control of behavioral state |
WO2014179331A2 (en) | 2013-04-29 | 2014-11-06 | The Board Of Trustees Of The Leland Stanford Junior University | Devices, systems and methods for optogenetic modulation of action potentials in target cells |
US11446331B2 (en) | 2013-05-10 | 2022-09-20 | The Brigham And Women's Hospital, Inc. | Wound healing and tissue engineering |
CN105829538A (en) | 2013-08-14 | 2016-08-03 | 小利兰·斯坦福大学托管委员会 | Silicone-modified polyester coating |
AU2014355072A1 (en) | 2013-11-26 | 2016-06-02 | Alliqua Biomedical, Inc. | Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing |
EP3126002B1 (en) | 2014-04-04 | 2020-07-15 | Photosonix Medical, Inc. | Methods, devices and systems for treating bacteria with mechanical stress energy and electromagnetic energy |
CA3177417A1 (en) | 2014-04-18 | 2015-10-22 | Ulthera, Inc. | Band transducer ultrasound therapy |
CN107405133B (en) | 2014-12-24 | 2021-06-08 | 声科影像有限公司 | Shear wave elastic imaging method and device suitable for anisotropic medium imaging |
WO2016168385A2 (en) | 2015-04-14 | 2016-10-20 | Photosonix Medical, Inc. | Method and device for treatment with combination ultrasound-phototherapy transducer |
US10568516B2 (en) | 2015-06-22 | 2020-02-25 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging and/or optogenetic control of light-responsive neurons |
WO2017083869A1 (en) * | 2015-11-13 | 2017-05-18 | Orthoforge | Medical devices, systems and methods for monitoring and stimulating osteogenesis |
MX2018007094A (en) | 2016-01-18 | 2018-11-09 | Ulthera Inc | Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof. |
US11458069B2 (en) | 2016-04-18 | 2022-10-04 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods to treat medical conditions using reflexology zones |
US11389372B2 (en) | 2016-04-18 | 2022-07-19 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods |
US11389371B2 (en) | 2018-05-21 | 2022-07-19 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods |
US11389373B2 (en) | 2016-04-18 | 2022-07-19 | Softwave Tissue Regeneration Technologies, Llc | Acoustic shock wave therapeutic methods to prevent or treat opioid addiction |
SG11201809829UA (en) * | 2016-05-13 | 2018-12-28 | Smith & Nephew | Sensor enabled wound monitoring and therapy apparatus |
CN114631846A (en) | 2016-08-16 | 2022-06-17 | 奥赛拉公司 | System and method for cosmetic ultrasound treatment of skin |
US11294165B2 (en) | 2017-03-30 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modular, electro-optical device for increasing the imaging field of view using time-sequential capture |
TWI638159B (en) * | 2017-08-02 | 2018-10-11 | 南臺學校財團法人南臺科技大學 | Ultrasonic probe fixator |
US10398880B2 (en) * | 2017-11-02 | 2019-09-03 | J.D. Franco & Co., Llc | Medical systems, devices, and related methods |
WO2019164836A1 (en) | 2018-02-20 | 2019-08-29 | Ulthera, Inc. | Systems and methods for combined cosmetic treatment of cellulite with ultrasound |
US20210338486A1 (en) | 2018-10-18 | 2021-11-04 | T.J.Smith And Nephew,Limited | Tissue treatment device |
GB201817052D0 (en) | 2018-10-19 | 2018-12-05 | Smith & Nephew | Tissue treatment device |
RU2708787C1 (en) * | 2019-01-18 | 2019-12-11 | Валерий Викторович Педдер | Method for distant ultrasonic treatment of purulent wounds |
KR20210101481A (en) * | 2020-02-10 | 2021-08-19 | 한국과학기술연구원 | A device for removing senescent cells comprising an ultrasound output unit |
GB202005867D0 (en) | 2020-04-22 | 2020-06-03 | Smith & Nephew | Tissue treatment device |
GB202100527D0 (en) | 2021-01-15 | 2021-03-03 | Smith & Nephew | Systems and methods for managing operation of wound dressings or wound treatment devices |
Citations (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1063782A (en) | 1912-11-06 | 1913-06-03 | George Otto Dickey | Lamp-bracket for semaphore-signals. |
US1604870A (en) | 1926-05-07 | 1926-10-26 | Walter C Asman | Light fixture |
US2914829A (en) | 1957-04-10 | 1959-12-01 | Louis F Willemain | Grass catcher clamping device |
US2920853A (en) | 1957-11-18 | 1960-01-12 | Bufogle John | Guide for the ball float of flush tanks |
US3117571A (en) | 1957-02-28 | 1964-01-14 | Univ Illinois | Production of reversible changes in living tissue by ultrasound |
US3134451A (en) | 1962-03-14 | 1964-05-26 | Hanson Scale Co | Platform type bathroom scale |
US3193034A (en) | 1961-01-06 | 1965-07-06 | Continental Scale Corp | Weighing scale |
US3241375A (en) | 1961-04-03 | 1966-03-22 | Cons Electrodynamics Corp | Transducer |
US3304036A (en) | 1965-07-19 | 1967-02-14 | Claude R Davis | Golf cart umbrella mounting attachment |
US3310049A (en) | 1963-09-17 | 1967-03-21 | Air Shields | Ultrasonic cardiac volume measurements |
US3433663A (en) | 1964-05-04 | 1969-03-18 | Union Carbide Corp | Impregnated porous paper webs and method of obtaining same |
US3499437A (en) | 1967-03-10 | 1970-03-10 | Ultrasonic Systems | Method and apparatus for treatment of organic structures and systems thereof with ultrasonic energy |
US3521225A (en) | 1968-06-25 | 1970-07-21 | Jetronic Ind Inc | Underwater transducer and mounting bracket assembly |
US3550586A (en) | 1967-03-10 | 1970-12-29 | Ultrasonic Systems | Ultrasonic treatment method and device for fertilized ova and live embryos |
US3575050A (en) | 1968-12-04 | 1971-04-13 | Panametrics | Fluid flowmeter |
US3594993A (en) | 1966-11-14 | 1971-07-27 | Dexter Corp | Porous, bonded and impregnated, nonwoven filter sheet structure |
US3664626A (en) | 1970-07-30 | 1972-05-23 | Valley Decorating Co | Bracket for mounting decorations on a building front |
US3701352A (en) | 1970-12-01 | 1972-10-31 | Nathaniel L Bosworth | Abdominal wall punch |
US3714619A (en) | 1971-09-15 | 1973-01-30 | Gehring Kg Maschf | Universal transducer mounting bracket and assembly |
US3729182A (en) | 1970-11-19 | 1973-04-24 | Desert West Inc | Process and apparatus for recovering precious metals |
US3760799A (en) | 1972-03-02 | 1973-09-25 | D Crowson | Sonic teeth-cleaning apparatus and method |
US3767195A (en) | 1969-03-03 | 1973-10-23 | Lifecycle Inc | Programmed bicycle exerciser |
US3828769A (en) | 1973-02-28 | 1974-08-13 | H Mettler | Method and apparatus for ultrasonic treatment of lower tissues simultaneous with heating of subcutaneous, outer muscle and lower tissues |
US3855638A (en) | 1970-06-04 | 1974-12-24 | Ontario Research Foundation | Surgical prosthetic device with porous metal coating |
US3890953A (en) | 1971-04-06 | 1975-06-24 | Werner Kraus | Electrical apparatus generating a low frequency, alternating magnetic field for promoting the growth of bone and other body tissues |
US3961380A (en) | 1975-05-27 | 1976-06-08 | Garr Ernest J | Bathtub appliance with hot water bladder and heat chamber |
US3986212A (en) | 1975-04-11 | 1976-10-19 | Glasrock Products, Inc. | Composite prosthetic device with porous polymeric coating |
US4037592A (en) | 1976-05-04 | 1977-07-26 | Kronner Richard F | Guide pin locating tool and method |
US4105017A (en) | 1976-11-17 | 1978-08-08 | Electro-Biology, Inc. | Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment |
US4108165A (en) | 1977-06-20 | 1978-08-22 | Krautkramer-Branson, Incorporated | Transducer probe for pulse-echo ultrasonic exploration |
US4127125A (en) | 1975-12-22 | 1978-11-28 | Lion Hamigaki Kabushiki Kaisha | Devices for transmitting ultrasonic waves to teeth |
US4141524A (en) | 1977-02-28 | 1979-02-27 | Corvese Jr Louis | Tube holder for immobile patients |
US4164794A (en) | 1977-04-14 | 1979-08-21 | Union Carbide Corporation | Prosthetic devices having coatings of selected porous bioengineering thermoplastics |
US4170045A (en) | 1978-06-09 | 1979-10-09 | Estes Judith K | Hospital bathtub |
US4176664A (en) | 1978-03-13 | 1979-12-04 | Stanley Kalish | Impregnated bandage |
US4195517A (en) | 1978-12-18 | 1980-04-01 | The Foxboro Company | Ultrasonic flowmeter |
US4206516A (en) | 1976-12-15 | 1980-06-10 | Ontario Research Foundation | Surgical prosthetic device or implant having pure metal porous coating |
US4216766A (en) | 1979-09-07 | 1980-08-12 | The United States Of America As Represented By The Secretary Of The Navy | Treatment of body tissue by means of internal cavity resonance |
US4227111A (en) | 1979-03-28 | 1980-10-07 | The United States Of America As Represented By The Secretary Of The Navy | Flexible piezoelectric composite transducers |
US4229992A (en) | 1978-06-28 | 1980-10-28 | Mckee Clyde M | Mirror actuator |
US4233477A (en) | 1979-01-31 | 1980-11-11 | The United States Of America As Represented By The Secretary Of The Navy | Flexible, shapeable, composite acoustic transducer |
US4266533A (en) | 1976-11-17 | 1981-05-12 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
US4269797A (en) | 1979-11-22 | 1981-05-26 | Nikki Co., Ltd. | Bubble generator |
US4291025A (en) * | 1980-04-11 | 1981-09-22 | Laclede Professional Products, Inc. | Agar gel topical dressing |
US4296753A (en) | 1978-09-19 | 1981-10-27 | U.S. Philips Corporation | Support for a transducer for emitting and/or receiving ultrasonic signals in a given angular sector |
US4312536A (en) | 1980-06-05 | 1982-01-26 | Lo-Rich Enterprises, Inc. | Dunk seat |
US4315514A (en) | 1980-05-08 | 1982-02-16 | William Drewes | Method and apparatus for selective cell destruction |
US4315503A (en) | 1976-11-17 | 1982-02-16 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
US4347645A (en) | 1979-08-18 | 1982-09-07 | Ohta Company Limited | Self closing hinge |
US4351069A (en) | 1979-06-29 | 1982-09-28 | Union Carbide Corporation | Prosthetic devices having sintered thermoplastic coatings with a porosity gradient |
US4355428A (en) | 1976-07-02 | 1982-10-26 | S.A. Benoist Girard & Cie | Surgical prosthesis with grainy surface |
US4358105A (en) | 1980-08-21 | 1982-11-09 | Lifecycle, Inc. | Programmed exerciser apparatus and method |
US4361154A (en) | 1978-07-28 | 1982-11-30 | Massachusetts Institute Of Technology | Method for establishing, in vivo, bone strength |
US4365359A (en) | 1979-02-15 | 1982-12-28 | Raab S | PMMA Coated bone connective prostheses and method of forming same |
US4383533A (en) | 1981-02-10 | 1983-05-17 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Apparatus for determining changes in limb volume |
US4407044A (en) | 1979-08-18 | 1983-10-04 | Ohta Company Limited | Hinge |
US4410158A (en) | 1980-07-28 | 1983-10-18 | Maffei Eugene R | Over-bed television support frame |
US4421119A (en) | 1979-06-15 | 1983-12-20 | Massachusetts Institute Of Technology | Apparatus for establishing in vivo, bone strength |
US4431038A (en) | 1981-03-05 | 1984-02-14 | Rome Philip L | Actuating holder for combined electric eraser-pencil sharpeners |
US4440025A (en) | 1980-06-27 | 1984-04-03 | Matsushita Electric Industrial Company, Limited | Arc scan transducer array having a diverging lens |
US4441486A (en) | 1981-10-27 | 1984-04-10 | Board Of Trustees Of Leland Stanford Jr. University | Hyperthermia system |
US4446586A (en) | 1980-09-15 | 1984-05-08 | Silchor | Apparatus and method for bathing invalids |
US4452326A (en) | 1982-07-26 | 1984-06-05 | Tricolor Corporation | Corner bearing assembly for platform scale |
US4467659A (en) | 1982-08-12 | 1984-08-28 | Joseph Baumoel | Transducer having metal housing and employing mode conversion |
US4476874A (en) | 1982-06-01 | 1984-10-16 | Sri International | Ultrasonic imaging with volume flow measuring method and apparatus |
US4476847A (en) | 1981-11-19 | 1984-10-16 | Litton Industrial Products, Inc. | Adjustable double disc grinder dresser |
US4482942A (en) | 1981-03-30 | 1984-11-13 | Gte Products Corporation | Projection unit including glass reflector with insulative cap member |
US4511921A (en) | 1982-06-16 | 1985-04-16 | Rca Corporation | Television receiver with manual and selectively disabled automatic picture control |
US4530360A (en) | 1981-11-19 | 1985-07-23 | Duarte Luiz R | Method for healing bone fractures with ultrasound |
US4536894A (en) | 1983-08-04 | 1985-08-27 | Galante Jorge O | Hip prosthesis with flared porous bony ingrowth pads |
US4542744A (en) | 1983-03-23 | 1985-09-24 | North American Philips Corporation | Method and apparatus for remote tissue identification by statistical modeling and hypothesis testing of echo ultrasound signals |
US4542539A (en) | 1982-03-12 | 1985-09-24 | Artech Corp. | Surgical implant having a graded porous coating |
US4550714A (en) | 1983-03-09 | 1985-11-05 | Electro-Biology, Inc. | Electromagnetic coil insert for an orthopedic cast or the like |
US4556066A (en) | 1983-11-04 | 1985-12-03 | The Kendall Company | Ultrasound acoustical coupling pad |
US4557148A (en) | 1983-04-21 | 1985-12-10 | Yokogawa Hokushin Electric Corporation | Ultrasonic flowmeter |
US4570487A (en) | 1980-04-21 | 1986-02-18 | Southwest Research Institute | Multibeam satellite-pulse observation technique for characterizing cracks in bimetallic coarse-grained component |
US4570640A (en) | 1981-08-06 | 1986-02-18 | Barsa John E | Sensory monitoring apparatus and method |
US4570927A (en) | 1983-12-15 | 1986-02-18 | Wright State University | Therapeutic device |
US4573996A (en) | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
US4594662A (en) | 1982-11-12 | 1986-06-10 | Schlumberger Technology Corporation | Diffraction tomography systems and methods with fixed detector arrays |
US4612160A (en) | 1984-04-02 | 1986-09-16 | Dynamet, Inc. | Porous metal coating process and mold therefor |
US4627429A (en) | 1986-02-28 | 1986-12-09 | American Home Products Corporation | Storage-stable transdermal adhesive patch |
US4630323A (en) | 1985-08-02 | 1986-12-23 | Sage Dennis R | Bathtub liner |
US4644942A (en) | 1981-07-27 | 1987-02-24 | Battelle Development Corporation | Production of porous coating on a prosthesis |
US4646725A (en) | 1983-11-16 | 1987-03-03 | Manoutchehr Moasser | Method for treating herpes lesions and other infectious skin conditions |
US4657543A (en) | 1984-07-23 | 1987-04-14 | Massachusetts Institute Of Technology | Ultrasonically modulated polymeric devices for delivering compositions |
US4669483A (en) | 1984-07-21 | 1987-06-02 | Dornier System Gmbh | Lithotripsy system having locating and orienting apparatus |
US4677438A (en) | 1984-10-31 | 1987-06-30 | Hitachi, Ltd. | Method and apparatus for detecting an object or a condition indicating a defect in a medium |
US4680967A (en) | 1985-09-24 | 1987-07-21 | Krautkramer-Branson, Incorporated | Ultrasonic angle test probe having at least two transducers |
US4687195A (en) | 1984-02-06 | 1987-08-18 | Tri-Tech, Inc. | Treadmill exerciser |
US4689986A (en) | 1985-03-13 | 1987-09-01 | The University Of Michigan | Variable frequency gas-bubble-manipulating apparatus and method |
US4708127A (en) | 1985-10-24 | 1987-11-24 | The Birtcher Corporation | Ultrasonic generating system with feedback control |
US4710655A (en) | 1985-07-01 | 1987-12-01 | Ken Hayashibara | Resonant vibration-transmitting apparatus |
US4725272A (en) | 1981-06-29 | 1988-02-16 | Alza Corporation | Novel bandage for administering beneficial drug |
US4726099A (en) | 1986-09-17 | 1988-02-23 | American Cyanamid Company | Method of making piezoelectric composites |
US4763661A (en) | 1986-02-11 | 1988-08-16 | Stanford University | Filtered ultrasonic wave method and apparatus for detecting diseased tissue |
US4770184A (en) | 1985-12-17 | 1988-09-13 | Washington Research Foundation | Ultrasonic doppler diagnostic system using pattern recognition |
US4774959A (en) | 1986-01-10 | 1988-10-04 | Walker Sonix A/S | Narrow band ultrasonic frequency attentuation bone measurement system |
USRE32782E (en) | 1978-07-28 | 1988-11-15 | Massachusetts Institute Of Technology | Method for determining in vivo, bone strength |
US5425954A (en) * | 1993-09-30 | 1995-06-20 | Curafas Incorporated | Topical amino acid - vitamin complex compositions for pharmaceutical and cosmetic use |
US5904659A (en) * | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3729162A (en) * | 1971-03-05 | 1973-04-24 | F Salvato | Transom transducer mounting bracket |
US5143073A (en) | 1983-12-14 | 1992-09-01 | Edap International, S.A. | Wave apparatus system |
JPS6247359A (en) * | 1985-08-28 | 1987-03-02 | アロカ株式会社 | Ultrasonic bone stimulating apparatus |
US4913157A (en) * | 1986-06-03 | 1990-04-03 | Analog Devices, Inc. | Ultrasound method and apparatus for evaluating, in vivo, bone conditions |
JPS6336172A (en) * | 1986-07-29 | 1988-02-16 | Toshiba Corp | Ultrasonic coupler |
US4867169A (en) * | 1986-07-29 | 1989-09-19 | Kaoru Machida | Attachment attached to ultrasound probe for clinical application |
EG17822A (en) * | 1986-08-07 | 1991-03-30 | Alaa Edin El Ottefy | Direct current(dc)bone growth stimulator for treatment of pseudarthroses |
US4830015A (en) * | 1986-09-16 | 1989-05-16 | Kabushiki Kaisha Toshiba | Method and system for measuring an ultrasound tissue characterization |
US4920966A (en) * | 1986-10-02 | 1990-05-01 | Hon Edward H | Ultrasound transducer holder |
US4932951A (en) * | 1988-03-23 | 1990-06-12 | Life Resonances, Inc. | Method and apparatus for controlling tissue growth and an applied fluctuating magnetic field |
US5067940A (en) * | 1988-03-23 | 1991-11-26 | Life Resonances, Inc. | Method and apparatus for controlling the growth of cartilage |
US5100373A (en) * | 1989-01-09 | 1992-03-31 | Life Resonances, Inc. | Techniques for controlling osteoporosis using non-invasive magnetic fields |
US5106361A (en) * | 1988-03-23 | 1992-04-21 | Life Resonances, Inc. | Method and apparatus for controlling the growth of non-osseous non-cartilaginous solid connective tissue |
US4930358A (en) * | 1987-03-27 | 1990-06-05 | Tokyo Keiki Co., Ltd. | Method of and apparatus for measuring flow velocity by using ultrasonic waves |
BG46024A1 (en) * | 1987-05-19 | 1989-10-16 | Min Na Narodnata Otbrana | Method and device for treatment of bone patology |
US4787888A (en) * | 1987-06-01 | 1988-11-29 | University Of Connecticut | Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a) |
DE3826709C2 (en) * | 1987-08-05 | 1994-12-22 | Toshiba Kawasaki Kk | Ultrasound therapy device |
US4855911A (en) * | 1987-11-16 | 1989-08-08 | Massachusetts Institute Of Technology | Ultrasonic tissue characterization |
US4936303A (en) * | 1987-11-20 | 1990-06-26 | Ultrathermics | Ultrasonic heating apparatus and method |
US4905671A (en) * | 1988-01-11 | 1990-03-06 | Dornier Medizintechnik Gmbh | Inducement of bone growth by acoustic shock waves |
US5209221A (en) | 1988-03-01 | 1993-05-11 | Richard Wolf Gmbh | Ultrasonic treatment of pathological tissue |
US5088976A (en) * | 1988-03-23 | 1992-02-18 | Life Resonances, Inc. | Deformable magnetic field aiding coils for use in controlling tissue growth |
US5318561A (en) * | 1988-03-23 | 1994-06-07 | Life Resonances Inc. | Deformable magnetic field aiding coils for use in controlling tissue growth |
US5178134A (en) | 1988-03-30 | 1993-01-12 | Malmros Holding, Inc. | Ultrasonic treatment of animals |
US5054490A (en) * | 1988-05-11 | 1991-10-08 | Lunar Corporation | Ultrasonic densitometer device and method |
US5154189A (en) * | 1988-06-03 | 1992-10-13 | Oberlander Michael A | Method for repairing a torn meniscus |
US4941474A (en) * | 1988-07-01 | 1990-07-17 | Massachusetts Institute Of Technology | Multivariable analysis of bone condition |
US4926870A (en) * | 1988-08-30 | 1990-05-22 | Osteo-Technology, Inc. | Method and apparatus for ultrasonic analysis of bone strength in vivo |
US5003965A (en) * | 1988-09-14 | 1991-04-02 | Meditron Corporation | Medical device for ultrasonic treatment of living tissue and/or cells |
US5186162A (en) * | 1988-09-14 | 1993-02-16 | Interpore Orthopaedics, Inc. | Ultrasonic transducer device for treatment of living tissue and/or cells |
US5211160A (en) * | 1988-09-14 | 1993-05-18 | Interpore Orthopaedics, Inc. | Ultrasonic orthopedic treatment head and body-mounting means therefor |
US4993413A (en) * | 1988-09-22 | 1991-02-19 | The Research Foundation Of State University Of New York | Method and apparatus for inducing a current and voltage in living tissue |
US4984462A (en) * | 1989-05-30 | 1991-01-15 | Meditor Corporation | Detachable liquid level monitoring apparatus and method |
JPH03251240A (en) * | 1990-02-28 | 1991-11-08 | Toshiba Corp | Ultrasonic medical treatment device |
FR2660186A1 (en) * | 1990-03-27 | 1991-10-04 | Technomed Int Sa | USE OF ULTRASOUNDS FOR THE DETECTION AND LOCALIZATION OF A BONE ZONE, METHOD AND DEVICE FOR DETECTING AND LOCATING SUCH A BONE ZONE BY ULTRASOUND. |
JPH0482569A (en) * | 1990-07-26 | 1992-03-16 | Ito Chiyoutanpa Kk | Bone healing promoter |
JP2960494B2 (en) * | 1990-07-26 | 1999-10-06 | 伊藤超短波株式会社 | Bone fusion promoting device |
US5103806A (en) * | 1990-07-31 | 1992-04-14 | The Research Foundation Of State University Of New York | Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue |
US5191880A (en) * | 1990-07-31 | 1993-03-09 | Mcleod Kenneth J | Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue |
US5273028A (en) * | 1990-07-31 | 1993-12-28 | Mcleod Kenneth J | Non-invasive means for in-vivo bone-growth stimulation |
JP2747618B2 (en) * | 1990-11-05 | 1998-05-06 | 株式会社トキメック | Ultrasonic flow velocity measuring method and apparatus |
US5172692A (en) | 1990-12-05 | 1992-12-22 | Kulow Howard H | Method for inflammatory response management |
US5195941A (en) * | 1991-01-07 | 1993-03-23 | American Medical Electronics, Inc. | Contoured triangular transducer system for PEMF therapy |
US5316000A (en) | 1991-03-05 | 1994-05-31 | Technomed International (Societe Anonyme) | Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy |
US5314401A (en) * | 1991-03-29 | 1994-05-24 | Amei Technologies Inc. | Conformable PEMF transducer |
US5134999A (en) * | 1991-05-22 | 1992-08-04 | Walker Magnetics Group, Inc. | Ultrasonic transducer assembly |
DE4119524C2 (en) * | 1991-06-13 | 1998-08-20 | Siemens Ag | Device for the treatment of bone disorders by means of acoustic waves |
US5140988A (en) * | 1991-08-22 | 1992-08-25 | Animal Ultrasound Services, Inc. | Detection of abnormal bone structure in animals and carcasses with ultrasound |
DE4130761A1 (en) * | 1991-09-16 | 1993-03-18 | Siemens Ag | DEVICE FOR TREATING A LIVING BEING WITH ACOUSTIC WAVES |
US5230646A (en) * | 1991-11-15 | 1993-07-27 | Thorup Douglas O | Apparatus for mounting sonar device to fisherman's float tube |
US5415167A (en) * | 1992-01-10 | 1995-05-16 | Wilk; Peter J. | Medical system and associated method for automatic diagnosis and treatment |
US5230334A (en) * | 1992-01-22 | 1993-07-27 | Summit Technology, Inc. | Method and apparatus for generating localized hyperthermia |
US5304210A (en) * | 1992-01-28 | 1994-04-19 | Amei Technologies Inc. | Apparatus for distributed bone growth stimulation |
US5690608A (en) * | 1992-04-08 | 1997-11-25 | Asec Co., Ltd. | Ultrasonic apparatus for health and beauty |
US5259384A (en) * | 1992-07-30 | 1993-11-09 | Kaufman Jonathan J | Ultrasonic bone-assessment apparatus and method |
US5309898A (en) * | 1992-07-30 | 1994-05-10 | Kaufman Jonathan J | Ultrasonic bone-therapy and assessment apparatus and method |
US5285788A (en) * | 1992-10-16 | 1994-02-15 | Acuson Corporation | Ultrasonic tissue imaging method and apparatus with doppler velocity and acceleration processing |
US5394877A (en) * | 1993-04-01 | 1995-03-07 | Axon Medical, Inc. | Ultrasound medical diagnostic device having a coupling medium providing self-adherence to a patient |
US5630837A (en) * | 1993-07-01 | 1997-05-20 | Boston Scientific Corporation | Acoustic ablation |
US5413550A (en) * | 1993-07-21 | 1995-05-09 | Pti, Inc. | Ultrasound therapy system with automatic dose control |
US5417215A (en) * | 1994-02-04 | 1995-05-23 | Long Island Jewish Medical Center | Method of tissue characterization by ultrasound |
US5496256A (en) * | 1994-06-09 | 1996-03-05 | Sonex International Corporation | Ultrasonic bone healing device for dental application |
US5843741A (en) * | 1994-08-01 | 1998-12-01 | Massachusetts Insitute Of Technology | Method for altering the differentiation of anchorage dependent cells on an electrically conducting polymer |
US5547459A (en) * | 1994-10-25 | 1996-08-20 | Orthologic Corporation | Ultrasonic bone-therapy apparatus and method |
US5520612A (en) * | 1994-12-30 | 1996-05-28 | Exogen, Inc. | Acoustic system for bone-fracture therapy |
US5556372A (en) * | 1995-02-15 | 1996-09-17 | Exogen, Inc. | Apparatus for ultrasonic bone treatment |
JP3216769B2 (en) * | 1995-03-20 | 2001-10-09 | 富士電機株式会社 | Temperature and pressure compensation method for clamp-on type ultrasonic flowmeter |
JP3803417B2 (en) * | 1995-04-11 | 2006-08-02 | テルモ カーディオバスキュラー システムズ コーポレイション | Combination of mounting pad and level sensor ultrasonic transducer and mounting mechanism for mounting the sensor on the wall |
US6264650B1 (en) * | 1995-06-07 | 2001-07-24 | Arthrocare Corporation | Methods for electrosurgical treatment of intervertebral discs |
GB9510032D0 (en) * | 1995-05-18 | 1995-07-12 | Atomic Energy Authority Uk | Ultrasonic inspection |
US5578060A (en) | 1995-06-23 | 1996-11-26 | Chattanooga Group, Inc. | Physical therapy apparatus having an interactive interface, and method of configuring same |
US6048323A (en) * | 1995-10-02 | 2000-04-11 | Hon; Edward H. | Transducer support plate and tocodynamometer attachment system |
US5725482A (en) * | 1996-02-09 | 1998-03-10 | Bishop; Richard P. | Method for applying high-intensity ultrasonic waves to a target volume within a human or animal body |
WO1998000194A2 (en) * | 1996-06-28 | 1998-01-08 | Sontra Medical, L.P. | Ultrasound enhancement of transdermal transport |
US7108663B2 (en) * | 1997-02-06 | 2006-09-19 | Exogen, Inc. | Method and apparatus for cartilage growth stimulation |
ES2385305T3 (en) * | 1997-02-06 | 2012-07-20 | Exogen, Inc. | Kit to stimulate cartilage growth |
US6626901B1 (en) * | 1997-03-05 | 2003-09-30 | The Trustees Of Columbia University In The City Of New York | Electrothermal instrument for sealing and joining or cutting tissue |
US6090800A (en) * | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US5906580A (en) * | 1997-05-05 | 1999-05-25 | Creare Inc. | Ultrasound system and method of administering ultrasound including a plurality of multi-layer transducer elements |
US5954675A (en) * | 1997-07-07 | 1999-09-21 | Dellagatta; Enrico Michael | Method of ultrasonic therapy |
WO1999008598A1 (en) * | 1997-08-19 | 1999-02-25 | Mendlein John D | Ultrasonic transmission films and devices, particularly for hygienic transducer surfaces |
DE69933555T2 (en) * | 1998-05-06 | 2007-06-14 | Exogen, Inc., Memphis | ULTRASOUND SUPPORTS |
WO2000003207A1 (en) * | 1998-07-10 | 2000-01-20 | Panametrics, Inc. | Guided mode flow measurement system |
US6397683B1 (en) * | 1998-07-22 | 2002-06-04 | Flowtec Ag | Clamp-on ultrasonic flowmeter |
US6082181A (en) * | 1998-10-21 | 2000-07-04 | Battelle Memorial Institute | Ultrasonic fluid densitometer having liquid/wedge and gas/wedge interfaces |
US6061597A (en) * | 1998-12-18 | 2000-05-09 | Robert D. Rieman | Method and device for healing bone fractures |
JP2000217837A (en) * | 1999-02-01 | 2000-08-08 | Siemens Ag | Apparatus for holding positioning device and treatment bed with such apparatus |
US6328694B1 (en) * | 2000-05-26 | 2001-12-11 | Inta-Medics, Ltd | Ultrasound apparatus and method for tissue resonance analysis |
US20020115960A1 (en) * | 2000-08-24 | 2002-08-22 | Redding Bruce K. | Substance delivery system |
US6960173B2 (en) * | 2001-01-30 | 2005-11-01 | Eilaz Babaev | Ultrasound wound treatment method and device using standing waves |
US6478754B1 (en) * | 2001-04-23 | 2002-11-12 | Advanced Medical Applications, Inc. | Ultrasonic method and device for wound treatment |
AU2005205820B2 (en) * | 2004-09-04 | 2011-04-14 | Smith & Nephew Plc | Ultrasound device and method of use |
-
1997
- 1997-07-01 US US08/886,217 patent/US5904659A/en not_active Expired - Lifetime
-
1999
- 1999-01-13 US US09/229,855 patent/US6685656B1/en not_active Expired - Lifetime
- 1999-03-19 US US09/273,221 patent/US6273864B1/en not_active Expired - Lifetime
- 1999-03-19 US US09/273,214 patent/US6190336B1/en not_active Expired - Lifetime
-
2001
- 2001-08-13 US US09/928,594 patent/US7628764B2/en not_active Expired - Fee Related
Patent Citations (103)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1063782A (en) | 1912-11-06 | 1913-06-03 | George Otto Dickey | Lamp-bracket for semaphore-signals. |
US1604870A (en) | 1926-05-07 | 1926-10-26 | Walter C Asman | Light fixture |
US3117571A (en) | 1957-02-28 | 1964-01-14 | Univ Illinois | Production of reversible changes in living tissue by ultrasound |
US2914829A (en) | 1957-04-10 | 1959-12-01 | Louis F Willemain | Grass catcher clamping device |
US2920853A (en) | 1957-11-18 | 1960-01-12 | Bufogle John | Guide for the ball float of flush tanks |
US3193034A (en) | 1961-01-06 | 1965-07-06 | Continental Scale Corp | Weighing scale |
US3241375A (en) | 1961-04-03 | 1966-03-22 | Cons Electrodynamics Corp | Transducer |
US3134451A (en) | 1962-03-14 | 1964-05-26 | Hanson Scale Co | Platform type bathroom scale |
US3310049A (en) | 1963-09-17 | 1967-03-21 | Air Shields | Ultrasonic cardiac volume measurements |
US3433663A (en) | 1964-05-04 | 1969-03-18 | Union Carbide Corp | Impregnated porous paper webs and method of obtaining same |
US3304036A (en) | 1965-07-19 | 1967-02-14 | Claude R Davis | Golf cart umbrella mounting attachment |
US3594993A (en) | 1966-11-14 | 1971-07-27 | Dexter Corp | Porous, bonded and impregnated, nonwoven filter sheet structure |
US3499437A (en) | 1967-03-10 | 1970-03-10 | Ultrasonic Systems | Method and apparatus for treatment of organic structures and systems thereof with ultrasonic energy |
US3550586A (en) | 1967-03-10 | 1970-12-29 | Ultrasonic Systems | Ultrasonic treatment method and device for fertilized ova and live embryos |
US3521225A (en) | 1968-06-25 | 1970-07-21 | Jetronic Ind Inc | Underwater transducer and mounting bracket assembly |
US3575050A (en) | 1968-12-04 | 1971-04-13 | Panametrics | Fluid flowmeter |
US3767195A (en) | 1969-03-03 | 1973-10-23 | Lifecycle Inc | Programmed bicycle exerciser |
US3855638A (en) | 1970-06-04 | 1974-12-24 | Ontario Research Foundation | Surgical prosthetic device with porous metal coating |
US3664626A (en) | 1970-07-30 | 1972-05-23 | Valley Decorating Co | Bracket for mounting decorations on a building front |
US3729182A (en) | 1970-11-19 | 1973-04-24 | Desert West Inc | Process and apparatus for recovering precious metals |
US3701352A (en) | 1970-12-01 | 1972-10-31 | Nathaniel L Bosworth | Abdominal wall punch |
US3890953A (en) | 1971-04-06 | 1975-06-24 | Werner Kraus | Electrical apparatus generating a low frequency, alternating magnetic field for promoting the growth of bone and other body tissues |
US3714619A (en) | 1971-09-15 | 1973-01-30 | Gehring Kg Maschf | Universal transducer mounting bracket and assembly |
US3760799A (en) | 1972-03-02 | 1973-09-25 | D Crowson | Sonic teeth-cleaning apparatus and method |
US3828769A (en) | 1973-02-28 | 1974-08-13 | H Mettler | Method and apparatus for ultrasonic treatment of lower tissues simultaneous with heating of subcutaneous, outer muscle and lower tissues |
US3986212A (en) | 1975-04-11 | 1976-10-19 | Glasrock Products, Inc. | Composite prosthetic device with porous polymeric coating |
US3961380A (en) | 1975-05-27 | 1976-06-08 | Garr Ernest J | Bathtub appliance with hot water bladder and heat chamber |
US4127125A (en) | 1975-12-22 | 1978-11-28 | Lion Hamigaki Kabushiki Kaisha | Devices for transmitting ultrasonic waves to teeth |
US4037592A (en) | 1976-05-04 | 1977-07-26 | Kronner Richard F | Guide pin locating tool and method |
US4355428A (en) | 1976-07-02 | 1982-10-26 | S.A. Benoist Girard & Cie | Surgical prosthesis with grainy surface |
US4266533A (en) | 1976-11-17 | 1981-05-12 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
US4105017A (en) | 1976-11-17 | 1978-08-08 | Electro-Biology, Inc. | Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment |
US4315503A (en) | 1976-11-17 | 1982-02-16 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
US4266532A (en) | 1976-11-17 | 1981-05-12 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
US4206516A (en) | 1976-12-15 | 1980-06-10 | Ontario Research Foundation | Surgical prosthetic device or implant having pure metal porous coating |
US4141524A (en) | 1977-02-28 | 1979-02-27 | Corvese Jr Louis | Tube holder for immobile patients |
US4164794A (en) | 1977-04-14 | 1979-08-21 | Union Carbide Corporation | Prosthetic devices having coatings of selected porous bioengineering thermoplastics |
US4108165A (en) | 1977-06-20 | 1978-08-22 | Krautkramer-Branson, Incorporated | Transducer probe for pulse-echo ultrasonic exploration |
US4176664A (en) | 1978-03-13 | 1979-12-04 | Stanley Kalish | Impregnated bandage |
US4170045A (en) | 1978-06-09 | 1979-10-09 | Estes Judith K | Hospital bathtub |
US4229992A (en) | 1978-06-28 | 1980-10-28 | Mckee Clyde M | Mirror actuator |
USRE32782E (en) | 1978-07-28 | 1988-11-15 | Massachusetts Institute Of Technology | Method for determining in vivo, bone strength |
US4361154A (en) | 1978-07-28 | 1982-11-30 | Massachusetts Institute Of Technology | Method for establishing, in vivo, bone strength |
US4296753A (en) | 1978-09-19 | 1981-10-27 | U.S. Philips Corporation | Support for a transducer for emitting and/or receiving ultrasonic signals in a given angular sector |
US4195517A (en) | 1978-12-18 | 1980-04-01 | The Foxboro Company | Ultrasonic flowmeter |
US4233477A (en) | 1979-01-31 | 1980-11-11 | The United States Of America As Represented By The Secretary Of The Navy | Flexible, shapeable, composite acoustic transducer |
US4365359A (en) | 1979-02-15 | 1982-12-28 | Raab S | PMMA Coated bone connective prostheses and method of forming same |
US4227111A (en) | 1979-03-28 | 1980-10-07 | The United States Of America As Represented By The Secretary Of The Navy | Flexible piezoelectric composite transducers |
US4421119A (en) | 1979-06-15 | 1983-12-20 | Massachusetts Institute Of Technology | Apparatus for establishing in vivo, bone strength |
US4351069A (en) | 1979-06-29 | 1982-09-28 | Union Carbide Corporation | Prosthetic devices having sintered thermoplastic coatings with a porosity gradient |
US4407044A (en) | 1979-08-18 | 1983-10-04 | Ohta Company Limited | Hinge |
US4347645A (en) | 1979-08-18 | 1982-09-07 | Ohta Company Limited | Self closing hinge |
US4216766A (en) | 1979-09-07 | 1980-08-12 | The United States Of America As Represented By The Secretary Of The Navy | Treatment of body tissue by means of internal cavity resonance |
US4269797A (en) | 1979-11-22 | 1981-05-26 | Nikki Co., Ltd. | Bubble generator |
US4291025A (en) * | 1980-04-11 | 1981-09-22 | Laclede Professional Products, Inc. | Agar gel topical dressing |
US4570487A (en) | 1980-04-21 | 1986-02-18 | Southwest Research Institute | Multibeam satellite-pulse observation technique for characterizing cracks in bimetallic coarse-grained component |
US4315514A (en) | 1980-05-08 | 1982-02-16 | William Drewes | Method and apparatus for selective cell destruction |
US4312536A (en) | 1980-06-05 | 1982-01-26 | Lo-Rich Enterprises, Inc. | Dunk seat |
US4440025A (en) | 1980-06-27 | 1984-04-03 | Matsushita Electric Industrial Company, Limited | Arc scan transducer array having a diverging lens |
US4410158A (en) | 1980-07-28 | 1983-10-18 | Maffei Eugene R | Over-bed television support frame |
US4358105A (en) | 1980-08-21 | 1982-11-09 | Lifecycle, Inc. | Programmed exerciser apparatus and method |
US4446586A (en) | 1980-09-15 | 1984-05-08 | Silchor | Apparatus and method for bathing invalids |
US4383533A (en) | 1981-02-10 | 1983-05-17 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Apparatus for determining changes in limb volume |
US4431038A (en) | 1981-03-05 | 1984-02-14 | Rome Philip L | Actuating holder for combined electric eraser-pencil sharpeners |
US4482942A (en) | 1981-03-30 | 1984-11-13 | Gte Products Corporation | Projection unit including glass reflector with insulative cap member |
US4725272A (en) | 1981-06-29 | 1988-02-16 | Alza Corporation | Novel bandage for administering beneficial drug |
US4644942A (en) | 1981-07-27 | 1987-02-24 | Battelle Development Corporation | Production of porous coating on a prosthesis |
US4570640A (en) | 1981-08-06 | 1986-02-18 | Barsa John E | Sensory monitoring apparatus and method |
US4441486A (en) | 1981-10-27 | 1984-04-10 | Board Of Trustees Of Leland Stanford Jr. University | Hyperthermia system |
US4476847A (en) | 1981-11-19 | 1984-10-16 | Litton Industrial Products, Inc. | Adjustable double disc grinder dresser |
US4530360A (en) | 1981-11-19 | 1985-07-23 | Duarte Luiz R | Method for healing bone fractures with ultrasound |
US4542539A (en) | 1982-03-12 | 1985-09-24 | Artech Corp. | Surgical implant having a graded porous coating |
US4476874A (en) | 1982-06-01 | 1984-10-16 | Sri International | Ultrasonic imaging with volume flow measuring method and apparatus |
US4511921A (en) | 1982-06-16 | 1985-04-16 | Rca Corporation | Television receiver with manual and selectively disabled automatic picture control |
US4452326A (en) | 1982-07-26 | 1984-06-05 | Tricolor Corporation | Corner bearing assembly for platform scale |
US4467659A (en) | 1982-08-12 | 1984-08-28 | Joseph Baumoel | Transducer having metal housing and employing mode conversion |
US4594662A (en) | 1982-11-12 | 1986-06-10 | Schlumberger Technology Corporation | Diffraction tomography systems and methods with fixed detector arrays |
US4550714A (en) | 1983-03-09 | 1985-11-05 | Electro-Biology, Inc. | Electromagnetic coil insert for an orthopedic cast or the like |
US4542744A (en) | 1983-03-23 | 1985-09-24 | North American Philips Corporation | Method and apparatus for remote tissue identification by statistical modeling and hypothesis testing of echo ultrasound signals |
US4557148A (en) | 1983-04-21 | 1985-12-10 | Yokogawa Hokushin Electric Corporation | Ultrasonic flowmeter |
US4536894A (en) | 1983-08-04 | 1985-08-27 | Galante Jorge O | Hip prosthesis with flared porous bony ingrowth pads |
US4556066A (en) | 1983-11-04 | 1985-12-03 | The Kendall Company | Ultrasound acoustical coupling pad |
US4646725A (en) | 1983-11-16 | 1987-03-03 | Manoutchehr Moasser | Method for treating herpes lesions and other infectious skin conditions |
US4570927A (en) | 1983-12-15 | 1986-02-18 | Wright State University | Therapeutic device |
US4573996A (en) | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
US4687195A (en) | 1984-02-06 | 1987-08-18 | Tri-Tech, Inc. | Treadmill exerciser |
US4612160A (en) | 1984-04-02 | 1986-09-16 | Dynamet, Inc. | Porous metal coating process and mold therefor |
US4669483A (en) | 1984-07-21 | 1987-06-02 | Dornier System Gmbh | Lithotripsy system having locating and orienting apparatus |
US4657543A (en) | 1984-07-23 | 1987-04-14 | Massachusetts Institute Of Technology | Ultrasonically modulated polymeric devices for delivering compositions |
US4677438A (en) | 1984-10-31 | 1987-06-30 | Hitachi, Ltd. | Method and apparatus for detecting an object or a condition indicating a defect in a medium |
US4689986A (en) | 1985-03-13 | 1987-09-01 | The University Of Michigan | Variable frequency gas-bubble-manipulating apparatus and method |
US4710655A (en) | 1985-07-01 | 1987-12-01 | Ken Hayashibara | Resonant vibration-transmitting apparatus |
US4630323A (en) | 1985-08-02 | 1986-12-23 | Sage Dennis R | Bathtub liner |
US4680967A (en) | 1985-09-24 | 1987-07-21 | Krautkramer-Branson, Incorporated | Ultrasonic angle test probe having at least two transducers |
US4708127A (en) | 1985-10-24 | 1987-11-24 | The Birtcher Corporation | Ultrasonic generating system with feedback control |
US4770184A (en) | 1985-12-17 | 1988-09-13 | Washington Research Foundation | Ultrasonic doppler diagnostic system using pattern recognition |
US4774959A (en) | 1986-01-10 | 1988-10-04 | Walker Sonix A/S | Narrow band ultrasonic frequency attentuation bone measurement system |
US4763661A (en) | 1986-02-11 | 1988-08-16 | Stanford University | Filtered ultrasonic wave method and apparatus for detecting diseased tissue |
US4627429A (en) | 1986-02-28 | 1986-12-09 | American Home Products Corporation | Storage-stable transdermal adhesive patch |
US4726099A (en) | 1986-09-17 | 1988-02-23 | American Cyanamid Company | Method of making piezoelectric composites |
US5425954A (en) * | 1993-09-30 | 1995-06-20 | Curafas Incorporated | Topical amino acid - vitamin complex compositions for pharmaceutical and cosmetic use |
US5904659A (en) * | 1997-02-14 | 1999-05-18 | Exogen, Inc. | Ultrasonic treatment for wounds |
US6190336B1 (en) * | 1997-02-14 | 2001-02-20 | Exogen, Inc. | Ultrasonic treatment for wounds |
Non-Patent Citations (82)
Title |
---|
"Development of Flexible Pieoelectric Transducers and Matching Layers for Exogen Incorporated," Final Report, Covering Period Apr. 1, 1997 to Feb. 28, 1998, Rutgers University. |
"Generation of Electric Potentials by Bone in Response to Mechanical Stress," Science Magazine, 137, 1063-1064 (Sep. 28, 2002). |
"Reflex Sympathetic Dystrophy, Does RSD Exist?" www.arbon.com (Jun. 4, 1997). |
"Reflex Sympathetic Dystrophy, Does RSD Exist?" www.arbon.com (Jun. 4, 1997).. |
"Reflex Sympathetic Dystrophy: The Pain That Doesn't Stop," tcc.cc.nc.us (Jun. 4, 1997). |
Abstract, (Proceedings of the 11th Int'l. Conference on Medical and Biological Engineering) "Ultrasonic Stimulation of Fracture Healing", 1976. |
Abstract, (Proceedings of the III Congress on Biomedical Engineering) "Ultrasonic Action on Callus Formation in Bones", 1975. |
Abstract, (Proceedings of the IV Brazilain Congress on Biomedical Engineering) "Ultrasound in the Treatment of Fractures", 1977. |
Acoustic Emission and Diagnosis of Osteoporosis, by S. Hanagud, G. T. Hannon and R. Clinton, 1974, Ultrasonic Symposium Proceedings (IEEE), pp. 77-81. |
Acoustic Emission in Bone Substance, by S. Hanagud, R.G. Clinton and J.P. Lopez, 1973, Biomechanics Symposium Proceedings (ASME), pp. 79-81. |
Acoustic Emission Inspection, by Adrian A. Pollock, 1992, ASM Handbook, vol. 17, Nondestructive Evaluation and Quality Control, pp. 278-293. |
Acoustic Emission Techniques in the Development of a Diagnostic Tool for Osteoporosis, by S. Hanagud and R. G. Clinton, 1975, Ultrasonic Symposium Proceedings (IEEE), pp. 41-45. |
Acoustic Emission-An Update, by Arthur E. Lord, Jr., 1981, Physical Acoustics, vol. XV, pp. 295-360. |
Application of an intelligent signal processing system to acoustic emission analysis, by Igo Grabec and Wolfgang Sachse, Mar. 1989, Acoustic Society of America, pp. 787-791. |
Application of correlation techniques for localization of acoustic emission sources, by I. Grabec, 1978, IPC Business Press Ltd., pp. 111-115. |
Arai et al., "The Effect of Ultrasound Stimulation on Disuse Osteoporosis", Brags 17, 1993. |
ASTM Designation: C1161-90, "Standard Test Method for Flexural Strength of Advanced Ceramics at Ambient Temperature," pp. 324-330.(Feb. 1991). |
ASTM Designation: D790M-93 Metric, "Standard Test Methods for flexural Properties of Unreinforced and Reinforced Plastics and Electrical Insulating Materials [Metric]", pp. 176-184, (Dec. 1993). |
Berridge, M.J., "Inositol Trisphosphate and Calcium Signaling", Nature (1993), 361: 315-325. |
Brochure: "The Science Behind the Technology," distributed by Smith & Nephew for Exogen. (no date). |
Caplan, et al., Clinical Orthopaedics and Related Research, No. 342:254-269 (1997). |
Cass, "Fabrication of Continuous Ceramic Fiber by the Viscous Suspension Spinning Process," Ceramic Bulletin, vol. 70, No. 3, pp. 424-429 (1991). |
Clarke, P.R. et al., "Physical and Chemical Aspects of Ultrasonic Disruption of Cells", JASA (1969), 47(2): 649-653. |
Clarke, P.R. et al., "Physical and Chemical Aspects of Ultrasonic Disruption of Cells", JASA (1969), 47(2); 649-653. |
Cook, Stephen and L. Patron, "Treatment of Osteorchondral Defects in Rabbits with SAFHS-A Mosaicplasty Model"-Final Report, EX1098-04R (Aug. 12, 1999). |
Cornejo, et al., "Large-Area Flexible-Array Piezoelectric Ceramic/Polymer composite Transducer for Bone Healing Acceleration," presented at ISAFXI, Montreux, Switzerland (1998). |
Duarte, L.R., "The Stimulation of Bone Growth by Ultrasound", Arch. Orthop. Trauma Surg (1983), 101: 153-159. |
Dyson, M., "Therapeutic Applications of Ultrasound", Biological Effects of Ultrasound (1985), Nyborg, W.L. and Ziskin, M.C., eds; Churchill Livingstone Inc., New York, Chapter 11. |
Fritton, et al., "Whole-Body Vibration in the Skeleton: Development of a Resonance-Based Testing Device," Annals of Biomedical Engineering, vol. 25, pp. 831-839 (1997). |
Goodship, A.E. et al., "The Influence of Induced Micromovement Upon the Healing of Experimental Tibial Fractures", J. Bone and Joint Surg. (1985), 67-B(4): 650-655. |
Goodship, et al., "Low magnitude high frequency mechanical stimulation of endochondral bone repair" 43rd Annual Meeting Orthopeadic Research Society, vol. 22, Sec. 1, Feb. 9-13 (1997). |
Grewe, et al., "Acoustic Properties of Particle Polymer Composite for Ultrasonic Transducer Backing Applications," IEEE, (1990). |
Grewe, Martha G., "Acoustic Matching and Backing Layer for Medical Ultrasonic Transducers," A Thesis in Solid State Science, The Pennsylvania State University; (May 1989), The Center for Ceramics Research, Rutgers. |
Gururaja, "Piezoelectrics for Medical Ultrasonic Imaging," Am. Ceram. Soc. Bull., vol. 73, No. 5, pp. 50-55 (May 1994). |
Gururaja, T., "Piezoelectric Composite Materials for Ultrasonic Transducer Applications," A Thesis in Solid State Science, The Pennsylvania State University, May 1984. |
Hall, et al., "The design and evaluation of ultrasonic arrays using 1-3 connectivity composites," SPIE, pp. 216-227, vol. 1733 (1992). |
Heckman, J.D. et al., "Acceleration of Tibial Fracture Healing by Non-Invasive Low-Intensity Pulsed Utrasound", J. Bone and Joint Surg. (1994), 76-A(1): 26-34. |
Hill, C.R., "Ultrasonic Exposure Thresholds for Changes in Cells and Tissues", JASA (1972), 52(2): 667-672. |
Howkins, S.D., "Diffusion Rates and the Effect of Ultrasound", Ultrasonics (1969), 129-130. |
International Search Report issued in related International Application No. PCT/US02/24389 mailed Nov. 15, 2002, 8 pages. |
J. Kenwright, et al., "Controlled Mechanical Stimulation in the Treatment of Fibial Fractures," Orthopedics, Clinical Orthopedics and Related Research (1989) 241:36-47. |
Jankovich, "The Effects of Mechanical Vibration on Bone Development in the Rat," J. Biomechanics, 1972, vol. 5, pp. 241-250. |
Kagawa et al., "Finite Element Simulation of a Composite Piezoelectric Ultrasonic Transducer," Transactions on Sonics and Ultrasonics, vol. SU-26, No. 2, Mar. 1979, 8 pages. |
Ko, "Preform Fiber Architecture for Ceramic-Matrix Composites," Ceramic Bulletin, vol. 68, No. 2, pp. 401-414(1989). |
Kristiansen, T.K. et al., "Accerlated Healing of Distal Radial Fractures with the Use of Specific, Low-Intensity Ultrasound", J. Bone and Joint Surg. (1997), 79-A(7) 961-973. |
Maurice Hilario, "Low-Intensity Ultrasound Radiation in the Tissue Repair of Trophic Leg Ulcers", 1983, University of Sao Paulo, pp. 1-125. |
McLeod, et al., "Improved Postural Stability Following Short Term Exposure to Low Level Whole Body Vibration," 44th Annual Meeting, Orthopaedic Research Society, Mar. 16-19, 1998, New Orleans, Louisiana, p. 89-15. |
Moran, et al., The Journal of Bone and Joint Surgery, 74-B:659-667 (1992). |
Newnham, et al., Connectivity and Piezoelectric-Pyroelectric Composites, Med. Res. Bull., vol. 13, pp. 525-536 (1978). |
Niemczewaki, B., "A Comparison of Ultrasonic Cavitation Intensity in Liquids," Ultrasonics, May 1980, pp. 107-110. |
Office Action issued in U.S. Appl. No. 09/700,014 mailed Mar. 12, 2004, 16 pages. |
Patent Abstracts vol. 013, n. 541 (E-854), Dec. 5, 1989, Japan. |
Pethica, B.A., et al., Abstract, Biological Repair and Growth Society, Jun. 1998. |
Phoenix (Business Wire), Jul. 8, 1997 via CompanyLink-OrthoLogic Corp. |
Photographs of Exercise Ergometer Developed by Biodex Medical Systems, Shirley, New York (3 pages, 2002). |
Photographs of Vibrations Platform Built by Julio Tous, Univiersitat Ramon Lllull, Barcelona, Spain (7 pages, 2002). |
Pilgrim, et al., "An Extension of the Composite Nomenclature Scheme," Med. Res. Bull., vol. 22, pp. 877-894 (1987). |
Pilla, A.A. et al., "Non-Invasive Low-Intensity Ultrasound Accelerates Bone Repair: Rabbit Fiubla Model and Human Colles' and Tibial Fractures", Annual Intl. Conference of IEEE-EMBS Proceedings (1990), 12:1573-1574. |
Pilla, et al., "Non-Invasive Low-Intensity Pulsed Ultrasound Accelerates Bone Healing in the Rabbit," Journal of Orthopaedic Trauma, vol. 4, No. 3, pp. 246-253 (1990). |
Powell, et al., "A Performance Appraisal of Flexible Array Structures Using a Facet Ensemble Scattering Technique," 1991 Ultrasonic Symposium, pp. 753-766. |
Powell, et al., "Flexible Ultrasonic Transducer Arrays for Nondestructive Evaluation Applications-Part I: The Theoretical Modeling Approach," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 43, No. 3, May 1996, pp. 385-392. |
Powell, et al., "Flexible Ultrasonic Transducer Arrays for Nondestructive Evaluation Applications-Part II: Performance Assessment of different Array Configurations," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 43, No. 3, May 1996, pp. 393-402. |
RSDnet.org "Reflex Sympathetic Dystrophy " www.rsdnet.org (Jun. 4, 1997). |
RSDnet.org "Reflex Sympathetic Dystrophy," www.rsdnet.org (Jun. 4, 1997). |
Safari, "Development of piezoelectric composites for transducers," J. Phys.France, 4:1129-1149 (1994). |
Sarvazyan, "Some General Problems of Biological Action of Ultrasound," IEEE Transactions on Sonics and Ultrasonics, vol. 30, No. 1, Jan. 1983. |
Selfridge, "Approximate Material Properties in Isotropic Materials," IEEE Transactions on Sonics and Ultrasonics, 9May 1985). |
Souquet, et al., "Design of Low-Loss Wide-Band Ultrasonic Transducers for Noninvasive Medical Application," IEEE Transactions on Sonics and Ultrasonics, pp. 75-81, vol. SU-26, No. 2, Mar. 1979. |
Tavakoli and Evans, "The Effect of Bone Structure on Ultrasonic Attenuation and Velocity," Ultrasonics, vol. 30, No. 6 (1992). |
Ter Haar, G., et al., "Basic Physics of Therapeutic Ultrasound", Physiotherapy (1987), 73(3): 110-113. |
Treatment of Osteochondral Defects in Rabbits with SAFHS-Part III, EX1097-01R (Aug. 26, 1997). |
Ultrasonics, Brochure, May 1980, pp. 108-110. |
Ultrasound as a Tool for Investigating Bone: Fundamental Principles and Perspectives for Use in Osteoporosis, by J. G. Bloch, 1993, Expanson Scientifique Francaise. |
Wallace, A.L.; Draper E.R.C.; Strachan, R.K.; McCarthy, I.D.; Hughes, S.P.F., "The Vascular Response to Fracture Micromovement", Clinical Orthopaedics and Related Research (1994), 301: 281-290. |
Waller, et al., "Poling of Lead Zirconate Titanate Ceramics and Flexible Piezoelectric Composites by the Corona Discharge Technique," J. Am. Ceram. Soc., 72(2):322-24 (1989). |
Wang, S.J. et al., "Low-Intensity Ultrasound Treatment Increases Strength in a Rat Femoral Fracture Model", J. Ortho Research (1994), 12: 40-47. |
Webster, D.F.et al., "The Role of Ultrasound-Induced Cavitation in the 'In Vitro' Stimulation of Collagen Synthesis in Human Fibroblasts", Ultrasonics (1980), 33-37. |
Winder, Alan, "Acoustic Emission Monitoring for the Detection, Localization and Classification of Metabolic Bone Disease," Acoustic Sciences Associates, Dec. 1995. |
Winder, Alan, "Synthetic Structural Imaging and Volume Estimation of Biological Tissue Organs," ,Acoustic Sciences Associates, Dec. 1995. |
Wu and Cubberly, "Measurement of Velocity and Attenuation of Shear Waves in Bovine Compact Bone Using Ultrasonic Spectroscopy," Med. & Biol., vol. 23, No. 1,129-134, 1997. |
Y. Qin, et al., "Correlation of In Vivo Bone Adaptation and Mechanical Parameters Using Low Magnitude, High Frequency Loading," 41st Annual Meeting Orthopaedic Research Soc., vol. 20-Sec. 1, Feb. 13-16 (1955). |
Yang, K.H. et al., "Exposure to Low-Intensity Ultrasound Treatment Increases Aggrecan Gene Expression in a Rat Femur Fracture Model", J. Ortho Research (1996), 14:802-809. |
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