|Publication number||US7368065 B2|
|Application number||US 11/159,934|
|Publication date||6 May 2008|
|Filing date||23 Jun 2005|
|Priority date||23 Jun 2005|
|Also published as||EP1736182A1, EP1736182B1, US20060289388|
|Publication number||11159934, 159934, US 7368065 B2, US 7368065B2, US-B2-7368065, US7368065 B2, US7368065B2|
|Inventors||Xiaofan Yang, Panjian Li, Todd Smith|
|Original Assignee||Depuy Products, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (15), Non-Patent Citations (19), Referenced by (102), Classifications (22), Legal Events (3)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The invention relates to orthopaedic implants and to methods and compositions for preparing such implants with a textured surface.
The effectiveness of an orthopaedic implant often depends upon the presence of an irregular surface on the implant, into which the bone may grow to create a natural joinder between the bone and the implant. Several techniques have been used to create implants with irregular surfaces. Grit blasting is one surface roughening technique, but grit blasting can cause significant changes to the surface topography by damaging the metal elements (e.g., beads) on the surface layer of the substrate. Other mechanical roughening techniques, such as scratching or burr grinding, have also been used. These techniques can also present drawbacks, including distortion of the substrate, removal of excess material, inability or difficulty to roughen certain surfaces, and inconsistent surface roughening.
Electrochemical or chemical etching techniques have also been used to roughen the surface of an implant. Chemical etching often involves using toxic reagents, such as methanol, or a strong acid at a high temperature (as high as 80° C., for example), or strong acid mixtures. Chemical etching, even under these stringent conditions, can require several hours to several days to roughen a surface. Chemical etching also presents the potential for preferential etching on grain boundaries, which can reduce the mechanical properties of the implants
Accordingly, there remains a need for improved and reliable methods to form an effective textured surface on a metal or metal alloy substrate. There is also a need for orthopaedic implants having a surface texture.
The present invention provides methods and compositions for preparing a substrate with a textured surface. The textured surface can be produced by exposing the surface of the implant to a etching solution comprising a hydrohalic acid or a mixture of a hydrohalic acid and an oxyacid (also known as “oxoacid”), a chlorine containing compound, and oxidant. The etching solution may optionally contain a phosphate containing compound as well. The substrate need only be exposed to the etching solution for a relatively short period of time to cause nanometer and micrometer sized indentations. This textured surface enhances adherence of non-metallic coatings or cells onto the textured surface, improves the retention of proteins on the surface when contacted with biological fluids, and encourages bone in-growth. The methods and compositions are useful for producing a uniform textured surface on hard metals such as cobalt and its alloys, especially cobalt chromium alloy.
A further advantage of the etching process of the invention is that it avoids the use of a hot mixture of methanol and acid, which produces potentially harmful vapors that present waste and disposal issues, or the use of a concentrated acid mix such as HCl and HNO3 mix, which is dangerous because of its corrosive properties. The etching process can also be conducted at room temperatures and for shorter durations of time.
In one aspect, the invention pertains to a chromium-containing biomedical implant comprising a textured surface with a plurality of pores or indentations. The indentations, which have a diameter in the range of about 200 nanometers to 15 micrometers, promote enhanced bone in-growth and attachment of a non-metallic coating or a cell to the textured surface. The chromium-containing implant can be any biocompatible metal alloy that contains chromium, such as cobalt-chromium. The textured surface of the implant can also be coated, after etching, with a non-metallic coating such as a bioceramic coating.
In another aspect, the invention pertains to a chromium-containing biomedical implant comprising a textured surface with a plurality of indentations. The textured surface is produced by an etching solution comprising hydrochloric acid at a concentration in the range of about 1M to 12M, phosphorous oxyacid, if present, at a concentration in the range of about 0.01M to 14M, a chlorine containing compound, if present, at a concentration in the range of about 0.01M to 2M, a phosphate containing compound, if present, at a concentration in the range of about 0.01M to 0.4M, and an oxidant at a concentration in the range of about 0.01M to 10M. The indentations have a diameter in the range of about 200 nanometers to 15 micrometers.
In another aspect, the invention pertains to an etching fluid, and a method of etching, in which the etching fluid comprising an acid selected from the group consisting of a hydrohalic acid, and a mixture of a hydrohalic acid and an oxyacid. The hydrohalic acid has a concentration range of about 1M to 12M, and the oxyacid has a concentration range of about 0.01M to 14M. The etching fluid also comprises a chlorine containing compound at a concentration in the range of about 0.01M to 2M, and an oxidant at a concentration in the range of about 0.01M to 10M. The etching solution produces a substantially uniform textured surface on a chromium containing biomedical implant, and the textured surface has a plurality of indentations having a diameter in the range of about 200 nanometers to 15 micrometers. The etching fluid may further comprise a phosphate containing compound.
In yet another aspect, the invention pertains to an etching fluid comprising hydrochloric acid at a concentration in the range of about 1M to 12M, a phosphorous oxyacid at a concentration in the range of about 0.01M to 14M, a chlorine containing compound at a concentration in the range of about 0.01M to 2M, a phosphate containing compound at a concentration in the range of about 0.01M to 0.4M, and an oxidant at a concentration in the range of about 0.01M to 10M. The etching solution produces a uniform textured surface on a substrate that promotes attachment of a non-metallic surface coating or a cell. Such a textured surface also enhances bone in-growth. The etching fluid creates a substantially uniform surface texture in a chromium containing biomedical implant under etching conditions conducted at a temperature in the range of about 10° C. to about 100° C.
In yet another aspect, the invention pertains to a method of producing a biomedical implant with a textured surface comprising exposing at least a portion of a chromium containing implant to an etching fluid. The implant can be incubated with the etching fluid at a temperature range of about 10° C. to about 100° C. until the implant contains a plurality of uniformly distributed indentations in the exposed portion of the implant. The textured surface with a plurality of indentations can be produced upon a smooth metal surface or a surface with metallic elements.
Certain exemplary embodiments of the invention will now be described to provide an overall understanding of the principles of the structure, function, manufacture, and use of the methods and compositions disclosed herein. Those skilled in the art will understand that the methods and compositions specifically described herein are non-limiting exemplary embodiments and that the scope of the present invention is defined solely by the claims. The features illustrated or described in connection with one exemplary embodiment may be combined with the features of other embodiments. Such modifications and variations are intended to be included within the scope of the present invention.
The invention provides a biomedical implant, e.g., an orthopaedic implant, that has at least on a portion thereof, a textured surface formed of a plurality of discrete indentations, e.g., pores. The pores of the textured surface can be in the nanometer to micron size range in both diameter and depth. The pores can have a diameter in the range of about 100 nanometers to 15 micrometers. In other embodiments, the pore size is in the range of about 200 nanometers to 5000 nanometers, or in the range of about 300 nanometers to 3000 nanometers, or in the range of about 300 nanometers to 1000 nanometers. The depths of the pores may vary; typically, the depths of the pores range up to about 2.4 microns, and, for example, can be in the range of about 0.8 microns to 2.4 microns, in the range of about 1.0 microns to 2.0 microns, in the range of about 1.2 microns to 1.8 microns, or in the range of about 1.4 microns to 1.6 microns.
In a further aspect, the implant is etched after having applied thereto a porous coating of metallic elements, such as metallic beads. After etching, the implant has a substantially uniform distribution of metallic elements across the entire surface of the implant upon which the textured surface is formed. That is, etching is able to occur three dimensionally such that the distribution of pores formed by the etching extends in all geometrical spatial dimensions. For example, etching and pore formation can occur such that pores are formed on irregular and undercut surfaces, as well as on smooth or flat portions. Each pore is a substantially discrete cavity formed in the surface of the implant. Adjacent pores are separated by a wall or projection that extends from the base of the pore. The walls of the projections may be of any shape, including columnar and irregular shaped. The textured surface with its minute indentations, deformations and/or raised portions is an opaque surface, slightly rough to the touch.
The biomedical implant upon which an etched surface can be formed can be any metal that has high mechanical strength, durability and biocompatibility. The mechanical properties of the implant should be those required for its intended use. In one embodiment, the metal is cobalt or its alloy containing chromium. Cobalt alloys can be created with one or more alloying elements such as carbon, chromium, iron, manganese, nickel, silicon, manganese, nitrogen and molybdenum. In one embodiment, the metal alloy is a cobalt-chromium alloy of the ASTM type F-75 (Standard Specification for Cobalt-28Chromium-6Molybdenum Alloy Castings and Casting Alloy for Surgical Implants, UNS R30075, Designation F75-01). In another embodiment, the metal alloy is a cobalt-chromium alloy of the ASTM type F-1537 (Standard Specification for Wrought Cobalt-28Chromium-6Molybdenum Alloys for Surgical Implants, UNS R31537, UNS R31538, and UNS R31539, Designation F1537-00). Exemplary materials typically contain chromium at about 26-30%, molybdenum at about 5-7%, and a balance of cobalt. Another example of a chromium-containing alloy that can be used is stainless steel. In addition to chromium-containing alloys, other examples of metals that can be used are those which are stable in the body, and include, but are not limited to, titanium and titanium alloys. One skilled in the art will appreciate that the implant can assume any shape that is required for its intended application.
The biomedical implant upon which an etched surface can be formed can be a metal body that has a coating of metallic elements adhered to at least a portion of the outer surface of the metal body. The metallic elements may form a three-dimensional porous surface geometry on the surface of the metallic biomedical implant. At least a portion of the metallic elements are interconnected to form pores between adjacent metallic elements (i.e. interstitial pores). These interstitial pores can range in size from about 10 microns to about 200 microns, and in some cases up to 750 microns. Such implants with coatings of metallic elements are referred to herein as “porous coated,” and the coating of metallic elements is referred to as a “porous coating.”
The metallic elements forming the porous coating can be provided in any suitable form. Generally, the metallic elements comprise metallic particles, metallic fibers, metallic wires, or combinations thereof. The metallic elements can be arranged in a predetermined pattern. For instance, a plurality of metallic fibers or wires can be arranged to form a mesh, which can be adhered to the outer surface of the metal body. In a preferred embodiment, the metallic elements comprise metallic particles. More preferably, the metallic particles comprise substantially spherical metallic beads. These metallic particles or beads can be of any suitable size. Typically, the size of the metallic particles or metallic beads is from about 40 microns to several millimeters.
The metallic elements of the porous coating are interconnected to each other and to the outer surface of the metal by bridges of metal. As used herein, these interconnecting bridges are referred to as grain boundaries. These boundaries serve to adhere the metallic elements to each other and to the outer surface of the metal body. An implant with such a porous network with such grain boundaries and interstitial pores may be made in any suitable manner. One suitable method is described in U.S. Pat. No. 3,855,638 and U.S. patent application Ser. No. 2004/0167632. In this method, a plurality of metallic elements are coated on the outer surface of the metal body, and then the implant is sintered to fuse the metallic elements to the body of the implant and to each other. The fusion of the metallic elements during the sintering process creates the boundaries between the metallic elements of the porous coating and between the outer surface of the metal boundary and the metallic elements of the porous coating. The sintering process preserves interstitial spaces or pores between the metallic elements. Typically, this method yields a metallic implant with interstitial pore sizes of greater than 20 microns.
The textured surface features of the implant provides an increased surface area. Further increases in the surface area can be provided by uniform textured surface features. Such increases in surface area can improve the adherence of any non-metallic coating applied to the substrate, and it can also enhance the biological fixation of the implant due, for example, to enhanced bone in-growth. Examples of suitable non-metallic coatings that can be applied to the substrate include, but are not limited to, hydroxyapatite, alumina, zirconia, titanium nitride and boron nitride. In another embodiment, the implant surface can be exposed to cells, or a population of cells such that the cells attach and adhere to the plurality of uniform raised portions and indentations. The attached cells can then proliferate and grow on the surface and encourage cell in-growth onto and into the implant. Examples of cells that can be used include, but are not limited to, chondroctyes, osteoblasts, and osteoclasts.
In yet another embodiment, the implant surface can be exposed to growth factors or proteins that enhance cell adhesion and cell growth. Suitable proteins include, but are not limited to, collagen, fibronectin, vitronectin, laminin, osteopontin, SPARC (secreted protein acidic and rich in cysteine), and bone morphogenetic proteins (BMPs). Suitable growth factors include, but are not limited to, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), basic fibroblast growth factor (bFGF), transforming growth factor beta (TGF-beta), and cartilage-derived growth factor (CDGF), hematopoetic growth factor (HGF), heparin binding growth factor, and the like.
In one embodiment, the etching fluid useful with the invention comprises an acid component selected from the group consisting of a hydrohalic acid or a mixture of a hydrohalic acid an oxyacid. The concentration of the hydrohalic acid can be in the range of about 1M to 12M and the concentration of the oxyacid can be in the range of about 0.01M to 14M. The etching fluid also comprises a chlorine containing compound at a concentration in the range of about 0.01M to 2M; and an oxidant at a concentration in the range of about 0.01M to 10M. The etching solution may further comprise a phosphate containing compound at a concentration in the range of about 0.01M to 0.4M. It will be appreciated that the concentration of the acid component that is used depends on whether one or both of the hydrogen halide acid and an oxyacid are used with the etching solution, and the identity of the specific hydrogen halide acid and/or oxyacid that is used. For example, if both a hydrogen halide acid and an oxyacid are used, the concentrations of each will be relatively lower in comparison to if just one of the acids was used. By way of further example, if only hydrochloric acid is used, without phosphorous oxyacid, then the concentration of hydrochloric acid can range from about 1M to about 12M. If, on the other hand, phosphorous oxyacid is used together with hydrochloric acid, then the concentration of hydrochloric acid that can be used is in the range of about 3M to about 5M; for example, hydrochloric acid with a concentration of about 3.4M can be used if in a mixture with 4.9M phosphoric oxyacid. It will be appreciated that the etching fluid need not include all of the components described above and shown in Example 1. Thus, in one embodiment, the etching fluid may comprise a hydrohalic acid and an oxidant. In another embodiment, the etching fluid may comprise a hydrohalic acid, an oxyacid, and an oxidant. In yet another embodiment, the etching fluid may comprise a hydrohalic acid, an oxyacid, an oxidant and a chlorine containing compound and/or a phosphate containing compound.
The hydrohalic acids are acids with a halogen group (sometimes referred to as hydrogen halide acids). Examples of hydrohalic acids include, but are not limited to hydrofluoric acid, , hydrochloric acid, hydrobromic acid, and hydroiodic acid. In one embodiment, the hydrohalic acid is hydrochloric acid at a concentration in the range of about 1M to 12M; about 3.5M to 8M; and about 4.6M.
Oxyacids have the general formula HaXbOc, where “a” represents the number of hydrogen atoms, “X” represents an element other than hydrogen or oxygen, “b” represents the number of “X” atoms, and “c” represents the number of oxygen atoms. Examples of oxyacids include, but are not limited to, nitric acid, (HNO3), sulfuric acid, (H2SO4), and phosphoric acid, (H3PO4). In one embodiment, the oxyacid is phosphorous oxyacid at a concentration in the range of about 0.01M to 14M; about 4M to 8M; and about 5.6M. Examples of phosphorous oxyacids include, but are not limited to, ortho-phosphoric acid (H3PO4), peroxomonophosphoric acid (H3PO5), diphosphoric acid (H4P2O7), peroxodiphosphoric acid (H4P2O8), triphosphoric acid (H5P3O10), hypophosphoric acid (H4P2O6), polyphosphoric acid (Hn+2PnO3n+1), where n is an integer up to 17, isohypophosphoric acid (H4P2O6), cyclo-trimetaphosphoric acid ((HPO3)3), phosphonic acid (H3PO3), cyclotetrametaphosphoric acid ((HPO3)4), diphosphonic acid (H4P2)5), polymetaphosphoric acid (HPO3)n, phosphinic acid (H3PO2), and anhydrous oxyacid.
A chlorine containing compound contains chlorine, which is typically present as a chloride. Most chlorides are salts that are formed either by direct union of chlorine with a metal or by reaction of hydrochloric acid (a water solution of hydrogen chloride) with a metal, a metal oxide, or an inorganic base. Examples of chlorine containing compounds include, but are not limited to, sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl2), ammonium chloride (NH4Cl) and ferrous chloride (FeCl3), or mixtures thereof. In one embodiment, the chlorine containing compound has a concentration in the range of about 0.01M to 2M; about 0.6M to 1.1M; and about 0.9M.
Phosphate containing compounds are minerals with a basic chemical unit of tetrahedral (PO4) groups with the phosphorus atom at the center and oxygen atoms at each of the four corners. This chemical group can be combined with metal ions in a 1:1 ratio, or usually in more complex combinations, with other ions such as hydroxyl groups (OH), a halogen, or even water molecules. Examples of phosphate containing compounds include, but are not limited to, potassium phosphate (K2HPO4), sodium phosphate (Na2HPO4), and sodium dihydrogen phosphate (NaH2PO4), and mixtures thereof. The phosphate containing compound can be used at a concentration of 0.01M to 0.4M. For example, if the phosphate containing compound is sodium dihydrogen phosphate, the concentration can be in the range of about 0.01M to 0.35M. If the phosphate containing compound is disodium hydrogen phosphate, the concentration can be in the range of about 0.01M to 0.3M. It will be appreciated that all forms of phosphate containing compounds can be used which include, but are not limited to, mono, di-, tri- salts of the compound, e.g., sodium phosphate, disodium phosphate, trisodium phosphate, and the like.
An oxidant is a substance that oxidizes another substance. Chemical groups that act as oxidants include, but are not limited to, peroxides (O2 −2), nitrates (NO3−), nitrites (NO2−), perchlorates (ClO4−), chlorates (ClO3−), chlorites (ClO2−), hypochlorites (ClO−), dichromates (Cr2O7 −2), permanganates (MnO4 −), and persulfates (S2O8 −2). Examples of oxidants include, but are not limited to, hydrogen peroxide, sodium peroxide, perchloric acid, ammonium persulphate. In one embodiment, the oxidant is hydrogen peroxide at a concentration in the range of about 0.32M to 10M; about 1M to 3.2M; and about 1.6M. In one embodiment, the hydrogen peroxide can be used at 1.6M concentration. In another embodiment, the oxidant is ammonium persulphate at a concentration in the range of about 0.01M to 1M; about 0.08M to 0.5M; and about 0.33M.
In one embodiment, the etching solution includes hydrochloric acid (HCl) at a concentration of about 4.6M, phosphoric acid (H3PO4) at a concentration of about 5.6M, ammonium chloride at a concentration of about 0.9M, sodium dihydrogen phosphate (NaH2PO4) at a concentration of about 0.01 to 0.35M and an oxidant, that can be hydrogen peroxide (H2O2) at a concentration of about 1.6M or ammonium persulphate (NH4)2S2O8 at a concentration of about 0.33M.
In another aspect, the invention pertains to methods of producing a chromium-based biomedical implant comprising a textured surface with a plurality of indentations. The textured surface is produced by exposing the implant to an etching solution comprising a hydrohalic acid at a concentration in the range of about 1M to 12M and/or an oxyacid at a concentration in the range of about 0.01M to 14M, a chlorine containing compound at a concentration in the range of about 0.01M to 2M, and an oxidant at a concentration in the range of about 0.01M to 10M. The etching solution can optionally contain other components, including a phosphate containing compound at a concentration in the range of about 0.01M to 0.4M. As noted above, the etching solution is effective to produce a uniform textured surface on a substrate with a plurality of indentations that can promote bone in-growth or the attachment of a non-metallic coating or a cell to the textured surface.
Before the etching process begins, the substrate surface can be cleaned using typical usual cleaning procedures, such as degreasing with detergent or an alkaline solution. The substrate surface may be degreased by ultrasonic cleaning in detergent, followed by ultrasonic cleaning in operating room water and drying. The cleaned metal surface is then exposed to a suitable volume of etching solution in a container or bath. The volume of the etching solution depends on the surface area of the substrate for which etching is desired. In some instances, the entire surface of the implant will be etched, and thus the volume of the etching solution should be sufficient to cover the entire implant. In other applications, only a portion of the implant will be etched and only a desired portion of the implant need be exposed to the etching solution. One skilled in the art will readily appreciate the volume of etching solution that is required for a given etching procedure.
The etching procedure of the invention can be conducted at a range of temperatures. In exemplary embodiments, the temperature of the etching solution during the etching process can be maintained within the range of about 10° C.-100° C., and preferably in the range of about 20° C.-40° C. In one embodiment, the etching solution can be maintained at room temperature (i.e., about 20-25° C.) during the etching process.
One skilled in the art will also appreciate that etching can be conducted for a variable time period. In exemplary embodiments, the etching process can be carried out for a period of time within the range of about 1 to 60 minutes, preferably about 10 to 30 minutes. Following the etching process, the metal surface can be washed, as known in the art, to remove any residual etching fluid.
As noted above, the etching process of the invention results in uniformly distributed indentations over the exposed substrate surface without reducing the mechanical properties of the implant. Such uniform etching provides advantages over other, known etching techniques. For example, some etching techniques can result in preferential etching, which is primarily focused at an interface of surface geometries, or at the boundaries between the metallic elements of the porous coating. Preferential etching often results in a non-uniformly etched surface and can lead to compromised mechanical properties; for example, the boundaries between metallic elements of the porous coating can be degraded by preferential etching. The results shown below illustrate that porous coated samples having a rough, irregular surface texture can be etched according to the invention in such a way that a uniform distribution of pores is obtained on all etched surfaces, regardless of the surface geometry before etching. Thus, preferential etching at the boundaries or interface between beads of the samples is avoided and the mechanical properties of the sample are preserved. Accordingly, the etching process can be carried out on surfaces of various geometries, including internal or undercut surfaces, planar surfaces, and non-planar surfaces. The resulting textured surface provides a surface with enhanced bonding properties and/or properties for receipt of a non-metallic coating.
The mechanical properties of the implant can be tested using a shearing test by determining the implants ability to withstand a shear force applied to the surface thereof. For example, the mechanical properties of the metallic implant can be measured using any of the techniques for testing metallic coatings set forth in ASTM F1044-99 entitled, “Standard Test Method for Shear Testing of Calcium Phosphate Coatings and Metallic Coatings.” For example, the mechanical properties implant is measured by embedding a portion of the metallic implant in a curable material (e.g., acrylic resin or polymer), and then applying a load to the implant in a direction intended to pull the implant from the body of the curable material. Typically, an implant which has been subjected to the chemical etching method of the invention can withstand a shear force of about 13,000 kPa (about 2,000 psi), about 20,000 kPa (about 3,000 psi), or about 27,000 kPa (about 4,000 psi) or more.
The following example is illustrative of the principles and practice of this invention. Numerous additional embodiments within the scope and spirit of the invention will become apparent to those skilled in the art.
This example demonstrates the preparation of a textured surface with a plurality of indentations using the etching fluid of the invention. All chemical reagents were obtained from Fischer Scientific. The samples used were cobalt-chromium substrates coated with POROCOAT® cobalt-chromium alloy beads, available from DePuy Orthopaedics, Inc. A portion of the each sample was exposed to an etching solution according to the present invention. The identity of each etching solution was evaluated, as well as the time of exposure to the etching solution at room temperature, are described in detail below in
Collectively, these results show that the etching solution of the invention provides a relatively mild etching solution that is able to achieve a uniform, nanometer and micrometer sized textured surface over the surface exposed to the etching solution. The time of exposure to the etching fluid may vary, although a uniformed textured surface can be produced with as little as four minutes of exposure. Thus, etching of an entire surface can be performed rapidly in a very short period of time.
One skilled in the art will appreciate further features and advantages of the invention based on the above-described embodiments. Accordingly, the invention is not to be limited by what has been particularly shown and described, except as indicated by the appended claims. All publications and references cited herein are expressly incorporated herein by reference in their entirety.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4094679 *||7 Feb 1977||13 Jun 1978||Fuji Photo Film Co., Ltd.||Process for reducing halftone dot images|
|US4818559 *||29 Jul 1986||4 Apr 1989||Sumitomo Chemical Company, Limited||Method for producing endosseous implants|
|US5705082||26 Jan 1995||6 Jan 1998||Chromalloy Gas Turbine Corporation||Roughening of metal surfaces|
|US5986169 *||31 Dec 1997||16 Nov 1999||Biorthex Inc.||Porous nickel-titanium alloy article|
|US6033582||16 Jan 1998||7 Mar 2000||Etex Corporation||Surface modification of medical implants|
|US6096140 *||22 Aug 1997||1 Aug 2000||Nihon Hyomen Kagaku Kabushiki Kaisha||Treating solution and treating method for forming protective coating films on metals|
|US6491723 *||1 Mar 1999||10 Dec 2002||Implant Innovations, Inc.||Implant surface preparation method|
|US20030065401||24 Jul 2002||3 Apr 2003||Mark Amrich||Textured surface having undercut micro recesses in a surface|
|US20030108659||14 Jan 2003||12 Jun 2003||Syntheon, Llc||Implantable metallic medical articles having microporous surface structure|
|US20030130736||24 Oct 2002||10 Jul 2003||Simon Raab||Bone connective prosthesis and method of forming same|
|US20040121290||16 Sep 2003||24 Jun 2004||Lynntech, Inc.||Biocompatible implants|
|US20040167632||24 Feb 2003||26 Aug 2004||Depuy Products, Inc.||Metallic implants having roughened surfaces and methods for producing the same|
|US20050049716||22 Nov 2002||3 Mar 2005||Sven Wagener||Bearing and composite structure|
|US20050112397||23 Jul 2004||26 May 2005||Rolfe Jonathan L.||Assembled non-random foams|
|WO2002060507A1||29 Jan 2002||8 Aug 2002||Isotis S.A.||A method for applying a bioactive coating on a medical device|
|1||CRC Handbook of Metal Etchants, CRC Press, Boston, 315-316 (1991).|
|2||European Search Report , from related EP 06252690.0, dated Jul. 28, 2006.|
|3||European Search Report , from related EP 06252704.9, dated Jul. 28, 2006.|
|4||European Search Report, from related EP 06252690.0, dated Jul. 28, 2006.|
|5||European Search Report, from related Ep 06252704.9, dated Jul. 28, 2006.|
|6||*||Ferrari, Journal of Prosthetic Dentistry, vol. 62, pp. 516-521, (1989).|
|7||Ferrari, M. et al., "Evaluation of a Chemical Etching Solution for Nickel-Chromium-Beryllium and Chromium-Cobalt Alloys," J. Prosthetic Dentistry 62(5):516 (1989).|
|8||Jokela-Hietamaki, M. et al., "Resin Bond to Electrolytically Etched Cobalt-Chromium Alloys," Scandinavian J. Dental Res. 95(1):82 (1987).|
|9||Liu, L. et al., "Etched Casting Resin Bonded Bridge: The Laboratory Study of Electrolytic Etching of a Co-Cr Alloy," Chinese Oral Med. J. 22(5):287 (Chinese, English @ 311)(1987).|
|10||Liu, X, et al., "Surface Modification of Titanium, Titanium Alloys, and Related Materials for Biomedical Applications," Mat. Sci. & Eng. R. 47:49-121 (2004).|
|11||Liu, X. et al., "Surface Modification of Titanium, Titanium Alloys, and Related Materials for Biomedical Applications," Mat. Sci. & Eng. R. 47:49-121 (2004).|
|12||*||Mendelson, Journal of Applied Physics, vol. 32, pp. 1579-1583, (1961).|
|13||Nabadalung, D. et al., "Effectiveness of Adhesive Systems for a Co-Cr Removable Partial Denture Alloy," J. Prosthodontics 7(1):17 (1998).|
|14||Petzow, G. et al., Metallographic Etching, Am. Soc. for Metals, Ohio, 51 (1978).|
|15||Reclaru, L. et al., "Cobalt-Chromium Dental Alloys Enriched with Precious Metals," European Cells & Materials 7(Supp.2):51 (2004).|
|16||*||S. Catledge, Journal of Nanoscience & Technology, vol. 2, No. 3, pp. 1-20, (2002).|
|17||*||S.Wolf, Silicon Processing for the VLSI Era, vol. 1, Lattice press (1986), p. 518.|
|18||Sarac, Y. et al., "The Effects of Different Metal Surface Treatments on Marginal Microleakage in Resin-Bonded Restorations," Tr. J. of Medical Sciences 28:685 (1998).|
|19||*||W. Kern, Handbook of Semiconductor Wafer Cleaning Technology, William Andrew Pub. (1993), pp. 120-128.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7931683 *||27 Jul 2007||26 Apr 2011||Boston Scientific Scimed, Inc.||Articles having ceramic coated surfaces|
|US7938855||2 Nov 2007||10 May 2011||Boston Scientific Scimed, Inc.||Deformable underlayer for stent|
|US7942926||11 Jul 2007||17 May 2011||Boston Scientific Scimed, Inc.||Endoprosthesis coating|
|US7976915||23 May 2007||12 Jul 2011||Boston Scientific Scimed, Inc.||Endoprosthesis with select ceramic morphology|
|US7981150 *||24 Sep 2007||19 Jul 2011||Boston Scientific Scimed, Inc.||Endoprosthesis with coatings|
|US8002823||11 Jul 2007||23 Aug 2011||Boston Scientific Scimed, Inc.||Endoprosthesis coating|
|US8029554||2 Nov 2007||4 Oct 2011||Boston Scientific Scimed, Inc.||Stent with embedded material|
|US8066763||11 May 2010||29 Nov 2011||Boston Scientific Scimed, Inc.||Drug-releasing stent with ceramic-containing layer|
|US8066770 *||20 Dec 2007||29 Nov 2011||Depuy Products, Inc.||Sintered coatings for implantable prostheses|
|US8067054||5 Apr 2007||29 Nov 2011||Boston Scientific Scimed, Inc.||Stents with ceramic drug reservoir layer and methods of making and using the same|
|US8070797||27 Feb 2008||6 Dec 2011||Boston Scientific Scimed, Inc.||Medical device with a porous surface for delivery of a therapeutic agent|
|US8071156||4 Mar 2009||6 Dec 2011||Boston Scientific Scimed, Inc.||Endoprostheses|
|US8187620||27 Mar 2006||29 May 2012||Boston Scientific Scimed, Inc.||Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents|
|US8216632||2 Nov 2007||10 Jul 2012||Boston Scientific Scimed, Inc.||Endoprosthesis coating|
|US8221822||30 Jul 2008||17 Jul 2012||Boston Scientific Scimed, Inc.||Medical device coating by laser cladding|
|US8231980||3 Dec 2009||31 Jul 2012||Boston Scientific Scimed, Inc.||Medical implants including iridium oxide|
|US8287937||24 Apr 2009||16 Oct 2012||Boston Scientific Scimed, Inc.||Endoprosthese|
|US8353949||10 Sep 2007||15 Jan 2013||Boston Scientific Scimed, Inc.||Medical devices with drug-eluting coating|
|US8361161 *||8 May 2009||29 Jan 2013||Fondel Finance B.V.||Kit and method for fixating a prosthesis or part thereof and/or filling osseous defects|
|US8403991||22 Dec 2011||26 Mar 2013||Titan Spine Llc||Implant with critical ratio of load bearing surface area to central opening area|
|US8431149||27 Feb 2008||30 Apr 2013||Boston Scientific Scimed, Inc.||Coated medical devices for abluminal drug delivery|
|US8435302||25 May 2012||7 May 2013||Titan Spine, Llc||Instruments and interbody spinal implants enhancing disc space distraction|
|US8449603||17 Jun 2009||28 May 2013||Boston Scientific Scimed, Inc.||Endoprosthesis coating|
|US8475536||29 Jan 2010||2 Jul 2013||DePuy Synthes Products, LLC||Methods and devices for implants with improved cement adhesion|
|US8480749||6 Jun 2012||9 Jul 2013||Titan Spine, Llc||Friction fit and vertebral endplate-preserving spinal implant|
|US8496710||10 Aug 2012||30 Jul 2013||Titan Spine, Llc||Interbody spinal implant having a roughened surface topography|
|US8545568||25 May 2012||1 Oct 2013||Titan Spine, Llc||Method of using instruments and interbody spinal implants to enhance distraction|
|US8551176||27 Jun 2012||8 Oct 2013||Titan Spine, Llc||Spinal implant having a passage for enhancing contact between bone graft material and cortical endplate bone|
|US8556902||8 Mar 2011||15 Oct 2013||Arthrosurface Incorporated||System and method for retrograde procedure|
|US8562684||31 May 2012||22 Oct 2013||Titan Spine, Llc||Endplate-preserving spinal implant with an integration plate having a roughened surface topography|
|US8562685||10 Aug 2012||22 Oct 2013||Titan Spine, Llc||Spinal implant and integration plate for optimizing vertebral endplate contact load-bearing edges|
|US8574615||25 May 2010||5 Nov 2013||Boston Scientific Scimed, Inc.||Medical devices having nanoporous coatings for controlled therapeutic agent delivery|
|US8585765||31 May 2012||19 Nov 2013||Titan Spine, Llc||Endplate-preserving spinal implant having a raised expulsion-resistant edge|
|US8585766||31 May 2012||19 Nov 2013||Titan Spine, Llc||Endplate-preserving spinal implant with an integration plate having durable connectors|
|US8585767||31 May 2012||19 Nov 2013||Titan Spine, Llc||Endplate-preserving spinal implant with an integration plate having durable connectors|
|US8591590||10 Aug 2012||26 Nov 2013||Titan Spine, Llc||Spinal implant having a transverse aperture|
|US8617242 *||14 Feb 2008||31 Dec 2013||Conformis, Inc.||Implant device and method for manufacture|
|US8617248||9 Aug 2012||31 Dec 2013||Titan Spine, Llc||Spinal implant having variable ratios of the integration surface area to the axial passage area|
|US8632604 *||20 Oct 2010||21 Jan 2014||Depuy International Limited||Medical implant device|
|US8663230||1 Mar 2011||4 Mar 2014||Arthrosurface Incorporated||Retrograde delivery of resurfacing devices|
|US8673018||1 Feb 2011||18 Mar 2014||AMx Tek LLC||Methods of using water-soluble inorganic compounds for implants|
|US8696759||15 Apr 2009||15 Apr 2014||DePuy Synthes Products, LLC||Methods and devices for implants with calcium phosphate|
|US8735773||10 Jun 2011||27 May 2014||Conformis, Inc.||Implant device and method for manufacture|
|US8758442||26 Jul 2012||24 Jun 2014||Titan Spine, Llc||Composite implants having integration surfaces composed of a regular repeating pattern|
|US8758443||10 Sep 2012||24 Jun 2014||Titan Spine, Llc||Implants with integration surfaces having regular repeating surface patterns|
|US8771343||15 Jun 2007||8 Jul 2014||Boston Scientific Scimed, Inc.||Medical devices with selective titanium oxide coatings|
|US8814939||25 Jul 2012||26 Aug 2014||Titan Spine, Llc||Implants having three distinct surfaces|
|US8815273||27 Jul 2007||26 Aug 2014||Boston Scientific Scimed, Inc.||Drug eluting medical devices having porous layers|
|US8815275||28 Jun 2006||26 Aug 2014||Boston Scientific Scimed, Inc.||Coatings for medical devices comprising a therapeutic agent and a metallic material|
|US8834571||28 Jun 2013||16 Sep 2014||Titan Spine, Llc||Interbody spinal implant having a roughened surface topography|
|US8840676 *||7 May 2010||23 Sep 2014||Smith & Nephew, Inc.||Modular trial heads for a prosthetic|
|US8864827||14 May 2012||21 Oct 2014||Arthrosurface Inc.||System and method for joint resurface repair|
|US8900292||6 Oct 2009||2 Dec 2014||Boston Scientific Scimed, Inc.||Coating for medical device having increased surface area|
|US8920491||17 Apr 2009||30 Dec 2014||Boston Scientific Scimed, Inc.||Medical devices having a coating of inorganic material|
|US8926615||29 Mar 2011||6 Jan 2015||Arthrosurface, Inc.||System and method for retrograde procedure|
|US8932346||23 Apr 2009||13 Jan 2015||Boston Scientific Scimed, Inc.||Medical devices having inorganic particle layers|
|US8940053||18 Oct 2013||27 Jan 2015||Titan Spine, Llc||Spinal implant and integration plate for optimizing vertebral endplate contact load-bearing edges|
|US8961614||9 Nov 2010||24 Feb 2015||Arthrosurface, Inc.||Articular surface implant and delivery system|
|US8992619||1 Nov 2011||31 Mar 2015||Titan Spine, Llc||Microstructured implant surfaces|
|US8992622||25 Oct 2013||31 Mar 2015||Titan Spine, Llc||Interbody spinal implant having a roughened surface topography|
|US9011546||2 Jun 2014||21 Apr 2015||Titan Spine, Llc||Composite implants having integration surfaces composed of a regular repeating pattern|
|US9044343||29 Jan 2013||2 Jun 2015||Arthrosurface Incorporated||System for articular surface replacement|
|US9055955||1 Mar 2011||16 Jun 2015||Arthrosurface Inc.||Bone resurfacing system and method|
|US9066716||30 Mar 2012||30 Jun 2015||Arthrosurface Incorporated||Suture coil and suture sheath for tissue repair|
|US9125756||3 Aug 2012||8 Sep 2015||Titan Spine, Llc||Processes for producing regular repeating patterns on surfaces of interbody devices|
|US9168147||13 Dec 2012||27 Oct 2015||Titan Spine, Llc||Self-deploying locking screw retention device|
|US9204873||3 Apr 2012||8 Dec 2015||Arthrosurface Incorporated||System and method for joint resurface repair|
|US9283076||19 Apr 2010||15 Mar 2016||Arthrosurface Incorporated||Glenoid resurfacing system and method|
|US9284409||17 Jul 2008||15 Mar 2016||Boston Scientific Scimed, Inc.||Endoprosthesis having a non-fouling surface|
|US9327051||2 Jun 2014||3 May 2016||Titan Spine, Llc||Implants with integration surfaces having regular repeating surface patterns|
|US9351745||5 Mar 2013||31 May 2016||Arthrosurface Incorporated||Trochlear resurfacing system and method|
|US9357989||28 Dec 2010||7 Jun 2016||Arthrosurface Incorporated||System and method for joint resurface repair|
|US9358029||11 Dec 2007||7 Jun 2016||Arthrosurface Incorporated||Retrograde resection apparatus and method|
|US9370426 *||8 Sep 2008||21 Jun 2016||Renishaw Plc||Relating to joints and/or implants|
|US9408686||22 Jan 2013||9 Aug 2016||Conformis, Inc.||Devices, systems and methods for manufacturing orthopedic implants|
|US9433511||11 Aug 2014||6 Sep 2016||Titan Spine, Llc||Interbody spinal implant having a roughened surface topography|
|US9439767||10 Oct 2013||13 Sep 2016||Conformis, Inc.||Patient-adapted and improved articular implants, designs and related guide tools|
|US9468448||28 Jun 2013||18 Oct 2016||Arthrosurface Incorporated||System and method for joint resurfacing and repair|
|US9492200||16 Apr 2013||15 Nov 2016||Arthrosurface Incorporated||Suture system and method|
|US9498349||1 Oct 2013||22 Nov 2016||Titan Spine, Llc||Expandable spinal implant with expansion wedge and anchor|
|US9592206||30 Jan 2014||14 Mar 2017||Orthomedex Llc||Methods of using water-soluble inorganic compounds for implants|
|US9615935||30 Jan 2014||11 Apr 2017||Titan Spine, Llc||Thermally activated shape memory spring assemblies for implant expansion|
|US9636229||20 Sep 2013||2 May 2017||Conformis, Inc.||Solid freeform fabrication of implant components|
|US20080147177 *||24 Sep 2007||19 Jun 2008||Torsten Scheuermann||Endoprosthesis with coatings|
|US20080300682 *||20 Dec 2007||4 Dec 2008||Depuy Products, Inc.||Sintered Coatings For Implantable Prostheses|
|US20090118820 *||2 Nov 2007||7 May 2009||Boston Scientific Scimed, Inc.||Deformable underlayer for stent|
|US20090138077 *||27 Jul 2007||28 May 2009||Boston Scientific Scimed, Inc.||Articles having ceramic coated surfaces|
|US20090266791 *||28 Apr 2008||29 Oct 2009||Depuy Products, Inc.||Implant surfaces and treatments for wear reduction|
|US20090306673 *||8 May 2009||10 Dec 2009||Fondel Finance B.V.||Kit and method for fixating a prosthesis or part thereof and/or filling osseous defects|
|US20100185294 *||23 Feb 2010||22 Jul 2010||Arthrosurface Incorporated||Nanorough Alloy Substrate|
|US20100268227 *||15 Apr 2009||21 Oct 2010||Depuy Products, Inc.||Methods and Devices for Bone Attachment|
|US20100268330 *||15 Apr 2009||21 Oct 2010||Depuy Products, Inc.||Methods and Devices for Implants with Calcium Phosphate|
|US20110125284 *||8 Sep 2008||26 May 2011||University Of Bath||Improvements in or Relating to Joints and/or Implants|
|US20110190902 *||29 Jan 2010||4 Aug 2011||Depuy Products, Inc.||Methods and devices for implants with improved cement adhesion|
|US20110196502 *||1 Feb 2011||11 Aug 2011||Walls James A||Methods of Using Water-Soluble Inorganic Compounds for Implants|
|US20120239160 *||7 May 2010||20 Sep 2012||Smith & Nephew, Inc.||Modular trial heads for a prosthetic|
|US20120253468 *||20 Oct 2010||4 Oct 2012||Depuy International Limited||Medical implant device|
|US20150018958 *||15 Sep 2014||15 Jan 2015||Titan Spine, Llc||Friction-fit spinal endplate and endplate-preserving method|
|US20150118650 *||8 Apr 2013||30 Apr 2015||Limacorporate Spa||Prosthetic Element for Bone Extremities Such as Fingers or Toes, or for Teeth, and Corresponding Production Method|
|EP2248539A2||14 Apr 2010||10 Nov 2010||DePuy Products, Inc.||Implantable medical devices|
|EP2251049A2||14 Apr 2010||17 Nov 2010||DePuy Products, Inc.||Methods and devices for bone attachment|
|EP2353548A2||19 Jan 2011||10 Aug 2011||DePuy Products, Inc.||Implants with improved cement adhesion|
|U.S. Classification||216/83, 216/53, 216/109, 427/2.26, 623/11.11, 623/23.37, 216/106, 623/23.63, 216/96, 623/23.53, 216/108, 427/2.24, 216/103, 623/23.29|
|Cooperative Classification||A61L27/047, C23F1/28, A61L27/50, A61L2400/18|
|European Classification||A61L27/50, A61L27/04R, C23F1/28|
|9 Sep 2005||AS||Assignment|
Owner name: DEPUY PRODUCTS, INC., INDIANA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:YANG, XIAOFAN;LI, PANJIAN;SMITH, TODD;REEL/FRAME:016759/0827;SIGNING DATES FROM 20050802 TO 20050804
|21 Sep 2011||FPAY||Fee payment|
Year of fee payment: 4
|21 Oct 2015||FPAY||Fee payment|
Year of fee payment: 8