US6545142B1 - Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors - Google Patents
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors Download PDFInfo
- Publication number
- US6545142B1 US6545142B1 US09/722,364 US72236400A US6545142B1 US 6545142 B1 US6545142 B1 US 6545142B1 US 72236400 A US72236400 A US 72236400A US 6545142 B1 US6545142 B1 US 6545142B1
- Authority
- US
- United States
- Prior art keywords
- sequence
- primers
- ligands
- domains
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Abstract
Description
Claims (2)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/722,364 US6545142B1 (en) | 1988-11-11 | 2000-11-28 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US10/290,252 US7306907B2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US10/290,233 US20040110941A2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US12/127,237 US20080299618A1 (en) | 1988-11-11 | 2008-05-27 | Single domain ligands, receptors comprising said ligands, methods for their production and use of said ligands and receptors |
Applications Claiming Priority (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888826444A GB8826444D0 (en) | 1988-11-11 | 1988-11-11 | Cloning immunoglobulin variable domains for expression by polymerase chain reaction |
GB8826444 | 1988-11-11 | ||
GB898906034A GB8906034D0 (en) | 1989-03-16 | 1989-03-16 | Recombinant dna method |
GB8906034 | 1989-03-16 | ||
GB898909217A GB8909217D0 (en) | 1989-04-22 | 1989-04-22 | Antibody binding |
GB8909217 | 1989-04-22 | ||
GB898911047A GB8911047D0 (en) | 1989-05-15 | 1989-05-15 | Antibody binding |
GB8911047 | 1989-05-15 | ||
GB8912652 | 1989-06-02 | ||
GB898912652A GB8912652D0 (en) | 1989-06-02 | 1989-06-02 | Antibody binding |
GB898913900A GB8913900D0 (en) | 1989-06-16 | 1989-06-16 | Antibody binding |
GB8913900 | 1989-06-16 | ||
GB898918543A GB8918543D0 (en) | 1989-08-15 | 1989-08-15 | Antibody binding |
GB8918543 | 1989-08-15 | ||
GBPCT/GB89/013444 | 1989-11-13 | ||
PCT/GB1989/001344 WO1990005144A1 (en) | 1988-11-11 | 1989-11-13 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US58037490A | 1990-09-11 | 1990-09-11 | |
US79680591A | 1991-11-25 | 1991-11-25 | |
US33204694A | 1994-11-01 | 1994-11-01 | |
US08/470,031 US6248516B1 (en) | 1988-11-11 | 1995-06-06 | Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors |
US09/722,364 US6545142B1 (en) | 1988-11-11 | 2000-11-28 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/470,031 Continuation US6248516B1 (en) | 1988-11-11 | 1995-06-06 | Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/290,233 Continuation US20040110941A2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US10/290,252 Continuation US7306907B2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
US6545142B1 true US6545142B1 (en) | 2003-04-08 |
Family
ID=27562806
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/470,031 Expired - Lifetime US6248516B1 (en) | 1988-11-11 | 1995-06-06 | Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors |
US09/722,364 Expired - Fee Related US6545142B1 (en) | 1988-11-11 | 2000-11-28 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US10/290,233 Abandoned US20040110941A2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US10/290,252 Expired - Fee Related US7306907B2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US12/127,237 Abandoned US20080299618A1 (en) | 1988-11-11 | 2008-05-27 | Single domain ligands, receptors comprising said ligands, methods for their production and use of said ligands and receptors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/470,031 Expired - Lifetime US6248516B1 (en) | 1988-11-11 | 1995-06-06 | Single domain ligands, receptors comprising said ligands methods for their production, and use of said ligands and receptors |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/290,233 Abandoned US20040110941A2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US10/290,252 Expired - Fee Related US7306907B2 (en) | 1988-11-11 | 2002-11-08 | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US12/127,237 Abandoned US20080299618A1 (en) | 1988-11-11 | 2008-05-27 | Single domain ligands, receptors comprising said ligands, methods for their production and use of said ligands and receptors |
Country Status (13)
Country | Link |
---|---|
US (5) | US6248516B1 (en) |
EP (1) | EP0368684B2 (en) |
JP (1) | JP2919890B2 (en) |
KR (1) | KR0184860B1 (en) |
AT (1) | ATE102631T1 (en) |
AU (1) | AU634186B2 (en) |
CA (1) | CA2002868C (en) |
DE (1) | DE68913658T3 (en) |
DK (1) | DK175392B1 (en) |
ES (1) | ES2052027T5 (en) |
FI (1) | FI903489A0 (en) |
NO (1) | NO903059L (en) |
WO (1) | WO1990005144A1 (en) |
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US20030232333A1 (en) * | 2000-04-17 | 2003-12-18 | Dyax Corp. | Novel methods of constructing librabries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel librabries |
US20060166252A1 (en) * | 2000-04-17 | 2006-07-27 | Ladner Robert C | Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins |
US20060246515A1 (en) * | 2002-08-12 | 2006-11-02 | Li Zhu | High throughput generation and affinity maturation of humanized antibody |
US20060257937A1 (en) * | 2000-12-18 | 2006-11-16 | Dyax Corp., A Delaware Corporation | Focused libraries of genetic packages |
US20080299618A1 (en) * | 1988-11-11 | 2008-12-04 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production and use of said ligands and receptors |
US20090136936A1 (en) * | 2007-05-01 | 2009-05-28 | George Georgiou | Immunoglobulin fc libraries |
US20090181855A1 (en) * | 2007-09-14 | 2009-07-16 | Adimab, Inc. | Rationally Designed, Synthetic Antibody Libraries and Uses Therefor |
US20090311181A1 (en) * | 2006-03-20 | 2009-12-17 | The Regents Of The University Of California | Engineered Anti-Prostate Stem Cell Antigen (PSCA) Antibodies for Cancer Targeting |
US20100056386A1 (en) * | 2007-09-14 | 2010-03-04 | Adimab, Inc. | Rationally Designed, Synthetic Antibody Libraries and Uses Therefor |
US20100330076A1 (en) * | 2009-06-30 | 2010-12-30 | George Georgiou | Immunoglobulin fc polypeptides |
US20110082054A1 (en) * | 2009-09-14 | 2011-04-07 | Dyax Corp. | Libraries of genetic packages comprising novel hc cdr3 designs |
US20110118147A1 (en) * | 2008-03-13 | 2011-05-19 | Ladner Robert C | Libraries of genetic packages comprising novel hc cdr3 designs |
US20110172125A1 (en) * | 2008-04-24 | 2011-07-14 | Dyax Corp. | Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs |
WO2012020096A1 (en) | 2010-08-13 | 2012-02-16 | Medimmune Limited | Monomeric polypeptides comprising variant fc regions and methods of use |
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US8952132B2 (en) | 2011-02-07 | 2015-02-10 | Research Development Foundation | Engineered immunoglobulin FC polypeptides |
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US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
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US5602015A (en) * | 1989-04-25 | 1997-02-11 | Igen, Inc. | Autoantibodies which enhance the rate of a chemical reaction |
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US5194585A (en) * | 1989-04-25 | 1993-03-16 | Igen, Inc. | Inhibitors of catalytic antibodies |
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US20030114659A1 (en) | 2003-06-19 |
KR0184860B1 (en) | 1999-04-01 |
DE68913658T2 (en) | 1994-09-08 |
NO903059D0 (en) | 1990-07-09 |
DE68913658T3 (en) | 2005-07-21 |
ES2052027T3 (en) | 1994-07-01 |
AU4520189A (en) | 1990-05-28 |
DK175392B1 (en) | 2004-09-20 |
JP2919890B2 (en) | 1999-07-19 |
NO903059L (en) | 1990-09-07 |
FI903489A0 (en) | 1990-07-10 |
US20030130496A1 (en) | 2003-07-10 |
EP0368684B1 (en) | 1994-03-09 |
DE68913658D1 (en) | 1994-04-14 |
US6248516B1 (en) | 2001-06-19 |
ATE102631T1 (en) | 1994-03-15 |
US7306907B2 (en) | 2007-12-11 |
AU634186B2 (en) | 1993-02-18 |
US20080299618A1 (en) | 2008-12-04 |
WO1990005144A1 (en) | 1990-05-17 |
CA2002868A1 (en) | 1990-05-11 |
DK164790D0 (en) | 1990-07-09 |
EP0368684B2 (en) | 2004-09-29 |
KR920700228A (en) | 1992-02-19 |
US20040110941A2 (en) | 2004-06-10 |
EP0368684A1 (en) | 1990-05-16 |
CA2002868C (en) | 2007-03-20 |
DK164790A (en) | 1990-09-07 |
JPH03502801A (en) | 1991-06-27 |
ES2052027T5 (en) | 2005-04-16 |
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