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A system and method for implanting pellets containing local anesthetic agents into tissues of the heart for temporary treatment of angina pectoris. The mechanism of delivery can be transcatheter via chambers of the heart, endoscopic epicardial approach via minimally invasive transthoracic access, or intraoperative epicardial approach during open-chest surgery.

Inventor: James F. Crittenden
Original Assignee: C. R. Bard, Inc.
Current U.S. Classification: 424/423
International Classification: A61F 202

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Claims

1. A method for providing local delivery of a therapeutic agent, comprising the step of

implanting a therapeutically effective amount of a local anesthetic agent into a portion of myocardial tissue.

2. A method according to claim 1, including the steps of

providing a catheter having a distal end adapted for delivering said therapeutic agent,
guiding said catheter into the interior of a patient's heart, and
disposing said distal end against an endocardial wall of the heart for implanting said therapeutic agent into the myocardial tissue.

3. A method according to claim 1 including the further step of

providing a steerable catheter having a drilling element for penetrating an endocardial wall.

4. A method according to claim 1, including the step of

delivering a pellet containing said therapeutic agent into the myocardial tissue.

5. A method according to claim 4, including the step of

delivering sequentially a plurality of pellets containing said therapeutic agent into the myocardial tissue.

6. A method according to claim 1, including the step of

providing a pellet containing said therapeutic agent and a radio-opaque material.

7. A method according to claim 1, including the step of

steering said catheter through the femoral artery and into the heart.

8. A method according to claim 1, including the step of

positioning a marker in a selected portion of a coronary artery, for providing a marker to identify a location for receiving said therapeutic agent.

9. A method according to claim 1, including the step of

penetrating said distal end of said catheter through said endocardial wall, for delivering said therapeutic agent into said myocardial tissue.

10. A method according to claim 1, including the step of

delivering through said distal end of said catheter, a pellet having a pointed or helical, conical end adapted to penetrate said endocardial wall.

11. A method according to claim 1, including the step of

delivering pellets containing said therapeutic agent and having an outer surface adapted to adhere said pellets to said endocardial wall.

12. A method according to claim 1, including the step of

endoscopically delivering said therapeutic agent through the epicardium.

13. A method according to claim 1, including the step of

implanting said therapeutic agent into the myocardial tissue during open-chest surgery.

14. A method for treating angina pectoris, comprising the steps of

identifying a portion of ischemic myocardial tissue, and
implanting a therapeutically effective amount of a therapeutic agent into the portion of ischemic myocardial tissue,
wherein said therapeutic agent is a local anesthetic agent.

15. A method according to claim 14, wherein the ischemic myocardial tissue is accessed transendocardially.

16. A method according to claim 14, wherein the ischernic myocardial tissue is accessed transepicardially.

17. A pellet, comprising

a therapeutically effective amount of a therapeutic agent having a local anesthetic agent surrounding a radio-opaque material, whereby delivery of the therapeutic agent is facilitated by viewing the position of the radio-opaque material relative to a position of a targeted site for implanting the pellet.

Drawings