|Publication number||US5596996 A|
|Application number||US 08/413,524|
|Publication date||28 Jan 1997|
|Filing date||30 Mar 1995|
|Priority date||30 Mar 1995|
|Also published as||CA2207614A1, DE69603265D1, DE69603265T2, EP0817656A1, EP0817656B1, WO1996030071A1|
|Publication number||08413524, 413524, US 5596996 A, US 5596996A, US-A-5596996, US5596996 A, US5596996A|
|Inventors||Mark A. Johanson, Michael S. Noone|
|Original Assignee||Medtronic, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Non-Patent Citations (2), Referenced by (82), Classifications (8), Legal Events (5)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates to guidewires, and more particularly, to high support guidewires with a flexible tube at the distal end. Such a guidewire can be used in PTCA procedures such as balloon angioplasty, atherectomy, stent implantation procedures, or radiology procedures.
One of the therapeutic procedures applicable to the present invention is known as percutaneous transluminal coronary angioplasty (PTCA). This procedure can be used, for example, to reduce aerial build-up of cholesterol fats or atherosclerotic plaque. Typically a guidewire is steered through vascular system to the site of therapy. A guiding catheter, for example, can then be advanced over the guidewire and a balloon catheter advanced within the guiding catheter over the guidewire. The balloon at the distal end of the catheter is inflated causing the site of the stenosis to widen. The original catheter can then be withdrawn and a catheter of a different size or another device such as an atherectomy device can be inserted.
The major considerations in guidewire design include steerability, flexibility, medial stiffness or support, bending in transition areas, tip formability and radiopacity. In a typical guidewire construction a tapered stainless steel core wire has a platinum spring coil wound around the tapered distal end of the core wire. The tapered area of the core wire is called the transition segment. The longer the tapered transition segment, the more flexible the guidewire. A blunt tip is typically welded to the distal end of the guidewire to reduce trauma to the blood vessel.
Support refers to a guidewire's ability to provide a strong "platform" or track for the catheter to move over as it is crossing the lesion. Support becomes crucial when the lesion is tight. Catheters are soft and rely heavily on the support provided by the guidewire. The spring coil is typically used to provide device support and maintain a consistent guidewire outer diameter. If the outer diameter of the guidewire is reduced, it will exert more force per unit area and may result in cutting through the blood vessel rather than tracking through the bends in the vessels. Increasing core wire diameter also assists in providing enhanced support. The spring coil wire is wound into a coil and placed over the core wire. The spring coil proximal end is difficult to attach to the core wire. A typical spring coil is approximately 0.002 inches in diameter thereby providing a very small area with which to attach to the core wire. Spring coil guidewire construction has been known in the art for many years. An early example of such guidewire construction includes U.S. Pat. No. 3,789,841 for a "Disposable Guide Wire" to Antoshkiw.
Transition refers to areas of changing diameter along the guidewire. A smooth transition gives the guidewire the ability to follow itself smoothly around vascular bends. If a stiffer portion of the guidewire behind the flexible tip does not follow the tip around vascular bends, the tip position may be lost. A guidewire with poor or rough transition will show elbows or bends in the vascular curves. Without smooth transitions a guidewire will not corner smoothly. Smooth transitions also facilitate the tracking of the balloon catheter over the wire when crossing the lesion.
U.S. Pat. No. 4,884,5791 to Engelson for "Catheter Guidewire" discloses a guidewire with proximal, intermediate and distal sections. The intermediate section has greater lubricity than the adjacent proximal and distal sections. The greater frictional coefficient in the distal end segment acts to anchor the end of the wire in a branch vessel when the guide wire has been advanced across the sharp-bend vessel junction. In FIG. 6, the distal segment of the core wire is incased in a polymer tube having a series of annular grooves to provide increased tube flexibility as well as greater frictional coefficient.
Elastomers and shape memory materials have been used in the catheter industry to promote elasticity and to promote tips that will return to a preformed curve after flexing. Super-elastic guidewires are known in the art, as for example, U.S. Pat. No. 4,925,445, to Sakamoto et al. for "Guide Wire for Catheter" which discloses a guidewire with at least portions of the inner core formed of the super-elastic metallic member. U.S. Pat. No. 5,067,489 to Lind for "Flexible Guide with Safety Tip" discloses an elongated, helically wound coil and an elongated flexible metal core of shape memory alloy. U.S. Pat. No. 5,069,226 to Yamauchi et al. for "Catheter Guidewire with Pseudo Elastic Shape Memory Alloy" discloses a catheter guide wire comprising a solid core wire of Ti-Ni shape memory alloy and an outer jacket coveting the core wire. The jacket is made of any one of synthetic resins such as polyethylene, polyvinylchloride, polyester, polypropylene, polyamide, polyurethane, polystyrene, fluoride resin, silicone rubber, and other elastomers. U.S. Pat. No. 5,243,996 to Hall for "Small-Diameter Superelastic Wire Guide" discloses a mandrel of metallic superelastic material, such as nitinol having a smoothly rounded tip attached to the distal tip of the mandrel and a coil attached at the distal region of the mandrel, the coil coaxially surrounding a portion of the distal region.
A drawback of spring coils as currently used in guidewires is that their indented surface may not pass through tight lesions effectively and may catch on devices being passed over them such as devices with cutting mechanisms. Another disadvantage is that they may provide too much flexibility for some devices to properly track over. Additionally, the spring coil is difficult to manufacture because it requires the wire to be helically wound with a uniform outer diameter, then placed over the core wire and welded thereto. The spring coil is also prone to separation where it attaches. An object of the invention is to eliminate the need of a guidewire spring coil while maintaining a uniform shaft outer diameter and providing sufficient support for more difficult PTCA procedures such as total occlusions, atherectomy, RotoblatorŽ (a registered trademark of Heart Technology, Inc.) and stent delivery. Another object of the invention is to provide steerability for wire placement. Yet another object of the invention is to avoid attachment weakness at the location where the spring coil would have attached to the core wire.
The above objects and advantages of the present invention, as well as others, are accomplished by providing a catheter guidewire having an elongate core wire, an elongate tube defining a tube lumen, the proximal end of the tube being affixed to the distal end of the core wire. The tube has a smooth exterior surface and one or more plug segments filling the tube lumen, each plug segment having a stiffness less than that of the core wire and less than that of the proximally preceding plug segment. The proximal end of the proximal most plug segment is affixed to the distal end of the core wire, the distal end of the tube is affixed to the distal most plug segment. A smoothly rounded distal tip extends beyond and is affixed to the distal end of the tube. The tube may be formed of a super-elastic metallic member or formed from a synthetic resin. The tube wall thickness is preferably between 0.002 inches and 0.005 inches.
FIG. 1 is an enlarged sectional view of a catheter guidewire according to the invention.
Prior art guidewires are currently constructed with a spring coil over the tapered distal end of the core wire to increase flexibility while maintaining a constant shaft outer diameter. A radiused blunt tip is soldered to the distal end of the core wire and spring coil. Applicant's guidewire 20 is a standard length of 175-310 cm long. Instead of a spring coil, however, applicant's guidewire 20 is constructed using a tube 30 which can be made of an elastomer or an alloy which is highly flexible without permanent deformation such as a shape memory alloy. The tube 30 can be approximately 10 cm to 40 cm long, preferably 30 cm which is the average length from the coronary vessel to the aortic arch. The tube 30 can preferably be made of a shape memory alloy such as nitinol manufactured by Raychem or Forukawa. A preferred embodiment uses NiTi 49-51 atom % Ni.
Shape memory alloys allow one to deform the alloy at a lower temperature with fairly low force and then with merely the application of heat, the material will exert a very strong force as it attempts to regain its previous shape. A useful shape memory alloy property includes an exceptional superelastic springiness if one deforms it at a temperature slightly above the transformation temperature. Shape memory alloys exhibit a very soft, energy absorbing behavior if used just below that temperature.
Examples of shape memory alloys which have a superelastic effect include AgCd 44-49 atom % Cd; AuCd 46.5-50 atom % Cd; CuAlNi 14-14.5 weight % Al, 3-4.5 weight % Ni; CuZn 38.5-41.5 weight % Zn; CuZn X few Weight % X, (X=Si, Sn, Al); InTi 18-23 atom % Ti; NiAl 36-38 atom % Al; NiTi 49-58 atom % Ni; FePt 25 atom % Pt; MnCu 5-35 atom % Cu; FeMnSi 32 weight % Mn, 6 weight % Si.
The use of superelastic NiTi wire has significant advantages over more conventional materials as well as other shape memory alloys. NiTi has a much lower effective modulus than stainless steel. Of the shape memory alloys, the NiTi family is the most commercially attractive system. The NiTi alloy has constituents which are not prohibitively expensive, can be fabricated with existing metalworking techniques and have greater shape memory strain (up to 8%) than other alloys. As seen from the shape memory alloy list supra, many contain expensive or exotic elements which are not as commercially attractive as NiTi.
Tube 30 can also be made of a synthetic resin elastomer such as any one of polyethylene, polyvinyl chloride, polyester, polypropylene, polyamide, polyurethane, polystyrene, and other elastomers. A fluoropolymer can also be used such as TEFLONŽ from E. I. Du Pont de Nemours & Company, Wilmington, Del. TEFLONŽ is a form of polytetrafluoroethylene (PTFE). Elastomers are lower cost then shape memory alloys. Shape memory alloys, however, provide more rigidity for better support than most of the elastomers.
The tube 30 is supported by a distally tapering core wire 25. The core wire 25 can be constructed of stainless steel. The tube 30 wall thickness varies depending of the size guidewire 20 used. The bigger the guidewire 20, the thicker the tube 30 must be to provide support. For example, a tube 30 wall thickness of 0.002 inches could be used for 0.010 inch guidewires. A tube 30 wall thickness of 0.005 inches could be used for 0.40 inch guidewires. The preferred tube 30 wall thickness is 0.0025 inches. A constant shaft outer diameter is maintained throughout the tube 30 by step grinding the distal end of the tube to coincide with the core wire tapered step 60.
For example, assume a standard 0.014 inch guidewire with a 30 cm tube 30. An example of a preferred embodiment would contain the following dimensions. The proximal end of the guidewire 20 body would have a substantially uniform diameter of 0.014 inches. The distal end of the core wire 25 would be ground over a length of 5 mm to tapered step 60 with a distal diameter of 0.009 inches. The distal end of the core wire 25 would be formed into a full radius 80 by a means such as grinding. The 5 mm long tapered step 60 is advantageous because it provides a large surface area with which to bond the tube 30 to the core wire 25.
The hollow portions of tube 30 can be plugged with segments of varying durometer plastic segments to create progressively decreasing stiffness toward the distal end of tube 30. Overall stiffness or floppiness can be achieved for different applications. For example, stiffer segments overall would be used for difficult PTCA procedures such as total occlusions, atherectomy, RotoblatorŽ (a registered trademark of Heart Technology, Inc.) and stent delivery. Floppier segments overall could be used for traversing especially tight lesions.
To achieve variable stiffness, the hollow portions of tube 30 can be plugged with one or more segments of varying durometer plastic such as a synthetic resin elastomer such as any one of polyethylene, polyvinyl chloride, polyester, polypropylene, polyamide, polyurethane, polystyrene, and other elastomers. The proximal end of the proximal most plug segment will be affixed to the radiused distal end 80 of the core wire. The distal most plug segment will be affixed to the tube 30 distal end by an adhesive bond or by a molding process. Adhesives such as cyanoacrylates or epoxy may be used. Those skilled in the art would recognize that any biocompatible adhesive would be satisfactory. The plastic plugs will be molded together after being inserted into the tube 30. Filling the tube 30 with a flexible material will render the tube 30 more kink resistant.
An example of a preferred embodiment would include three plugs of varying durometer plastic. Those skilled in the art would recognize that other numbers of plugs could be used. An acceptable three plug configuration includes the following combination of plug hardnesses and lengths. A material of Shore 75 D can be used for the approximately 10 cm long high durometer plug 65. A material of Shore 55 D can be used for the approximately 20 cm long medium durometer plug 70. A material of Shore 35 D can be used for the approximately 5 cm long low durometer plug 75. Procedures requiring high overall stiffness could be implemented using a material of a Shore 100 D for the approximately 20 cm long high durometer plug 65, a Shore 75 D material for the approximately 10 cm long medium durometer plug 70 and a Shore 55 D material approximately 3 cm long for the low durometer plug 75. Procedures requiring low overall stiffness could be implemented using a Shore 55 D material for the approximately 10 cm long high durometer plug 65, a Shore 40 D material for the approximately 10 cm long medium durometer plug 70, and a Shore 25 D material for the 15 cm long low durometer plug 75.
The proximal end of the tube 30 is affixed to the core wire 25 with an adhesive 35 at the proximal end of the first tapered step 60. Adhesives such as cyanoacrylates or epoxy may be used for joining the tube 30 to the core wire 25. Those skilled in the art would recognize that any biocompatible adhesive would be satisfactory. The present invention avoids the spring coil proximal end attachment problems of the prior art. A typical spring coil is approximately 0.002 inches in diameter thereby providing a very small area with which to attach to the core wire. The tube 30 of the present invention provides a 360 degree area of attachment to the core wire 25. The larger surface area provides for a more reliable attachment.
A tip 40 is formed out of the plastic material extending from the distal end of the low durometer plug 75. Tip 40 is radiused for an atraumatic tip. A radiopaque marker band 45 can be placed in the distal inner lumen of the tube 30 approximately 1-2 cm from the tip 40 enabling the physician to visualize the progress of the tip 40 under fluoroscopy. The marker band 45 can be attached by heat bonding or with an adhesive such as epoxy. Alternatively, having two radiopaque areas would give the physician a sense of scale. The medium durometer plug 70 or the low durometer plug 75 could be made of multiple segments with one of the segments made of plastic loaded with radiopaque fillings. Alternatively, either the medium durometer plug 70 or the low durometer plug 75 could be entirely made of plastic loaded with radiopaque fillings.
After attaching the tube 30 to the core wire 25, the guidewire 20 is coated with a lubricous coating 50 to enhance the movement of devices over it. The guidewire can be coated with a silicone oil or a hydrophilic coating. The advantage of Silicone is that it is inexpensive and easy to apply. The advantage of a hydrophilic coating is that it absorbs moisture and becomes slippery when inserted into the blood stream.
The preceding specific embodiments are illustrative of the practice of the invention. It is to be understood, however, that other expedients known to those skilled in the art or disclosed herein, may be employed without departing from the spirit of the invention or the scope of the appended claims.
______________________________________No. Component______________________________________20 Guidewire25 Core Wire30 Flexible Tube35 Adhesive40 Tip45 Radiopaque Marker Band60 Tapered Step65 High Durometer Plug70 Medium Durometer Plug75 Low Durometer Plug80 Full Radius85 Tube Lemen.______________________________________
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3789841 *||15 Sep 1971||5 Feb 1974||Becton Dickinson Co||Disposable guide wire|
|US4884579 *||18 Apr 1988||5 Dec 1989||Target Therapeutics||Catheter guide wire|
|US4925445 *||9 Feb 1989||15 May 1990||Fuji Terumo Co., Ltd.||Guide wire for catheter|
|US5067489 *||26 Oct 1990||26 Nov 1991||Flexmedics Corporation||Flexible guide with safety tip|
|US5069226 *||27 Apr 1990||3 Dec 1991||Tokin Corporation||Catheter guidewire with pseudo elastic shape memory alloy|
|US5176149 *||27 Dec 1991||5 Jan 1993||Nivarox-Far S.A.||Catheter guide support|
|US5243996 *||3 Jan 1992||14 Sep 1993||Cook, Incorporated||Small-diameter superelastic wire guide|
|US5452726 *||7 Oct 1994||26 Sep 1995||Scimed Life Systems, Inc.||Intravascular guide wire and method for manufacture thereof|
|1||*||55 Nitinol The Alloy with a Memory: Its Physical Metallurgy, Properties, and Applications, by Jackson et al., 1972, Prepared under contract for NASA. Foreword, pp. 1 2, p. 1037.|
|2||55-Nitinol-The Alloy with a Memory: Its Physical Metallurgy, Properties, and Applications, by Jackson et al., 1972, Prepared under contract for NASA. Foreword, pp. 1-2, p. 1037.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5843953 *||20 Oct 1995||1 Dec 1998||Merck & Co., Inc.||7-substituted 4-aza cholanic acid derivatives and their use|
|US5885227 *||25 Mar 1997||23 Mar 1999||Radius Medical Technologies, Inc.||Flexible guidewire with radiopaque plastic tip|
|US6139557 *||12 Apr 1999||31 Oct 2000||Prolifix Medical, Inc.||Apparatus for making wire with radial expansible guide section and methods of manufacturing the same|
|US6328822||25 Jun 1999||11 Dec 2001||Kiyohito Ishida||Functionally graded alloy, use thereof and method for producing same|
|US6371928||13 Oct 1999||16 Apr 2002||Prolifix Medical, Inc.||Guidewire for positioning a catheter against a lumen wall|
|US6406442||12 Apr 1999||18 Jun 2002||Prolifix Medical, Inc.||Guidewire for precision catheter positioning|
|US6493591||19 Jul 2000||10 Dec 2002||Medtronic, Inc.||Implantable active fixation lead with guidewire tip|
|US6527737 *||24 Jan 2001||4 Mar 2003||Tatsuo Kaneshige||Indwelling urethra catheter|
|US6569150 *||10 Apr 2001||27 May 2003||Scimed Life Systems, Inc.||Reinforced retention structures|
|US6652508||9 Nov 2001||25 Nov 2003||Scimed Life Systems, Inc.||Intravascular microcatheter having hypotube proximal shaft with transition|
|US6908443||20 Nov 2001||21 Jun 2005||Scimed Life Systems, Inc.||Intravascular guide wire and method for manufacture thereof|
|US6916386||23 Oct 2001||12 Jul 2005||Kiyohito Ishida||Core wire for a guide wire comprising a functionally graded alloy|
|US7063674||9 Oct 2002||20 Jun 2006||Scimed Life Systems, Inc.||Intravascular guide wire and method for manufacture thereof|
|US7097624||7 Jul 2003||29 Aug 2006||Scimed Life Systems, Inc.||Multi-layer and multi-section coils for guide wire|
|US7169139||10 Apr 2003||30 Jan 2007||Boston Scientific Scimed, Inc.||Reinforced retention structures|
|US7214201||17 Dec 2004||8 May 2007||Boston Scientific Scimed, Inc.||Intravascular guide wire and method for manufacture thereof|
|US7300438||29 Mar 2002||27 Nov 2007||C.R. Bard, Inc.||Electrophysiology catheter for mapping and/or ablation|
|US7488338||27 Dec 2001||10 Feb 2009||Boston Scientific Scimed, Inc.||Catheter having an improved torque transmitting shaft|
|US7637873 *||29 Dec 2009||Winston-Cook Medical Inc.||Wire guides having novel outer surface areas and reservoirs for enhancing hydrophilic properties and delivering therapeutic agents|
|US7670302||2 Mar 2010||Boston Scientific Scimed, Inc.||Super elastic guidewire with shape retention tip|
|US7785273 *||22 Sep 2003||31 Aug 2010||Boston Scientific Scimed, Inc.||Guidewire with reinforcing member|
|US7822464||26 Oct 2010||Siemens Aktiengesellschaft||Guidewire for vascular catheters|
|US7883474 *||8 Feb 2011||Target Therapeutics, Inc.||Composite braided guidewire|
|US7914516||25 Jan 2007||29 Mar 2011||Boston Scientific Scimed, Inc.||Reinforced retention structures|
|US7989703||2 Aug 2011||Fort Wayne Metals Research Products Corporation||Alternating core composite wire|
|US7993285||5 Nov 2002||9 Aug 2011||Boston Scientific Scimed, Inc.||Medical device having flexible distal tip|
|US8108054 *||31 Jan 2012||Pacesetter, Inc.||Active fixation implantable medical lead configured to indicate via fluoroscopy embedment of helical anchor in cardiac tissue|
|US8206377||22 Dec 2009||26 Jun 2012||Lightlab Imaging, Inc.||Torque limiter for an OCT catheter|
|US8206384||12 Oct 2007||26 Jun 2012||C. R. Bard, Inc.||Electrophysiology catheter for mapping and/or ablation|
|US8231647||31 Dec 2008||31 Jul 2012||Boston Scientific Scimed, Inc.||Catheter having an improved torque transmitting shaft|
|US8414635||9 Apr 2013||Idev Technologies, Inc.||Plain woven stents|
|US8419788||13 Jul 2012||16 Apr 2013||Idev Technologies, Inc.||Secured strand end devices|
|US8636731||4 Jun 2012||28 Jan 2014||Boston Scientific Scimed, Inc.||Electrophysiology catheter for mapping and/or ablation|
|US8718794||7 Dec 2011||6 May 2014||Pacesetter, Inc.||Method for indicating embedment of a helical anchor in cardiac tissue via fluoroscopy|
|US8739382||13 Jul 2012||3 Jun 2014||Idev Technologies, Inc.||Secured strand end devices|
|US8750964||22 Sep 2006||10 Jun 2014||Siemens Aktiengesellschaft||Device for determining the position of a medical instrument|
|US8764683||29 Dec 2010||1 Jul 2014||Mediguide Ltd.||Medical device guidewire with a position sensor|
|US8876880||13 Jul 2012||4 Nov 2014||Board Of Regents, The University Of Texas System||Plain woven stents|
|US8926590||21 Dec 2010||6 Jan 2015||Lightlab Imaging, Inc.||Torque limiter for an OCT catheter|
|US8961509||5 Nov 2012||24 Feb 2015||Boston Scientific Scimed, Inc.||Electrophysiology loop catheter|
|US8966733||28 May 2014||3 Mar 2015||Idev Technologies, Inc.||Secured strand end devices|
|US8974516||17 Dec 2013||10 Mar 2015||Board Of Regents, The University Of Texas System||Plain woven stents|
|US9149374||23 Apr 2014||6 Oct 2015||Idev Technologies, Inc.||Methods for manufacturing secured strand end devices|
|US9408729||20 Jan 2015||9 Aug 2016||Idev Technologies, Inc.||Secured strand end devices|
|US9408730||19 Jan 2016||9 Aug 2016||Idev Technologies, Inc.||Secured strand end devices|
|US20030032897 *||9 Oct 2002||13 Feb 2003||Scimed Life Systems, Inc.||Intravascular guide wire and method for manufacture thereof|
|US20030114777 *||18 Dec 2001||19 Jun 2003||Scimed Life Systems, Inc.||Super elastic guidewire with shape retention tip|
|US20030139689 *||23 Dec 2002||24 Jul 2003||Leonid Shturman||High torque, low profile intravascular guidewire system|
|US20030191450 *||10 Apr 2003||9 Oct 2003||Scimed Life Systems, Inc.||Reinforced retention structures|
|US20040039310 *||28 Aug 2003||26 Feb 2004||Burkett David H.||Wire joint and method|
|US20040059258 *||7 Jul 2003||25 Mar 2004||Scimed Life Systems, Inc.||Multi-layer and multi-section coils for guide wire|
|US20040087876 *||5 Nov 2002||6 May 2004||Scimed Life Systems, Inc.||Medical device having flexible distal tip|
|US20040193239 *||29 Mar 2002||30 Sep 2004||Falwell Gary S||Electrophysiology catheter for mapping and/or ablation|
|US20050065456 *||22 Sep 2003||24 Mar 2005||Scimed Life Systems, Inc.||Guidewire with reinforcing member|
|US20050107720 *||17 Dec 2004||19 May 2005||Burmeister Paul H.||Intravascular guide wire and method for manufacture thereof|
|US20050119590 *||17 Dec 2004||2 Jun 2005||Burmeister Paul H.||Intravascular guide wire and method for manufacture thereof|
|US20060116571 *||30 Nov 2005||1 Jun 2006||Siemens Aktiengesellschaft||Guidewire for vascular catheters|
|US20060129066 *||7 Feb 2006||15 Jun 2006||Burmeister Paul H||Intravascular guide wire and method for manufacture thereof|
|US20060211952 *||15 Mar 2006||21 Sep 2006||Wilson-Cook Medical Inc.||Wire guides having novel outer surface areas and reservoirs for enhancing hydrophilic properties and delivering therapeutic agents|
|US20060241366 *||31 Oct 2003||26 Oct 2006||Gary Falwell||Electrophysiology loop catheter|
|US20070066882 *||22 Sep 2006||22 Mar 2007||Siemens Aktiengesellschaft||Device for determining the position of a medical instrument|
|US20070123842 *||25 Jan 2007||31 May 2007||Teague James A||Reinforced Retention Structures|
|US20080039918 *||12 Oct 2007||14 Feb 2008||C.R. Bard, Inc.||Electrophysiology catheter for mapping and/or ablation|
|US20080290076 *||22 Oct 2007||27 Nov 2008||Idev Technologies, Inc.||Methods for Securing Strand Ends and the Resulting Devices|
|US20090076416 *||17 Sep 2007||19 Mar 2009||Medtronic Vascular, Inc.||Guidewire with Adjustable Core|
|US20090118759 *||31 Dec 2008||7 May 2009||Boston Scientific Scimed, Inc.||Catheter Having an Improved Torque Transmitting Shaft|
|US20090260852 *||22 Oct 2009||Fort Wayne Metals Research Products Corporation||Alternating core composite wire|
|US20100159117 *||1 Mar 2010||24 Jun 2010||Boston Scientific Scimed, Inc.||Super Elastic Guidewire With Shape Retention Tip|
|US20100198327 *||4 Feb 2009||5 Aug 2010||Pacesetter, Inc.||Active Fixation Implantable Medical Lead Configured to Indicate via Fluoroscopy Embedment of Helical Anchor in Cardiac Tissue|
|US20110151980 *||22 Dec 2009||23 Jun 2011||Lightlab Imaging, Inc.||Torque limiter for an oct catheter|
|US20130239565 *||16 Mar 2012||19 Sep 2013||GM Global Technology Operations LLC||Spatially graded sma actuators|
|US20140121648 *||11 Jun 2012||1 May 2014||Koninklijke Philips N.V.||Composite fiber guidewires|
|EP0967293A2 *||28 Jun 1999||29 Dec 1999||Kiyohito Ishida||Functionally graded alloy, use thereof and method for producing the same|
|EP2248543A1||15 Aug 2001||10 Nov 2010||Cordis Corporation||Fluid delivery systems for delivering fluids to multi-lumen catheters|
|EP2253340A1||15 Aug 2001||24 Nov 2010||Cordis Corporation||Fluid delivery systems for delivering fluids to multi-lumen catheters|
|EP2283891A2||7 Jan 2005||16 Feb 2011||Corazon Technologies, Inc.||Multilumen catheters and methods for their use|
|EP2286863A2||7 Jan 2005||23 Feb 2011||Corazon Technologies, Inc.||Multilumen catheters and methods for their use|
|EP2286864A2||7 Jan 2005||23 Feb 2011||Corazon Technologies, Inc.||Multilumen catheters and methods for their use|
|EP2627392A1 *||18 Oct 2011||21 Aug 2013||St. Jude Medical, Atrial Fibrillation Division, Inc.||Medical device guidewire with a position sensor|
|EP3006057A1||15 Aug 2001||13 Apr 2016||Cordis Corporation||Fluid delivery systems for delivering fluids to multi-lumen catheters|
|WO2001026725A1||13 Oct 2000||19 Apr 2001||Prolifix Medical, Inc.||Guidewire for positioning a catheter against a lumen wall|
|WO2004043530A1 *||31 Jul 2003||27 May 2004||Boston Sceintific Limited||Medical device having flexible distal tip|
|U.S. Classification||600/585, 600/434|
|International Classification||A61B5/00, A61M25/09, A61M25/01|
|Cooperative Classification||A61M25/09, A61M2025/09083|
|30 Mar 1995||AS||Assignment|
Owner name: MEDTRONIC, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JOHANSON,MARK A.;NOONE, MICHAEL S.;REEL/FRAME:007473/0969;SIGNING DATES FROM 19950329 TO 19950330
|27 Jul 2000||FPAY||Fee payment|
Year of fee payment: 4
|18 Aug 2004||REMI||Maintenance fee reminder mailed|
|28 Jan 2005||LAPS||Lapse for failure to pay maintenance fees|
|29 Mar 2005||FP||Expired due to failure to pay maintenance fee|
Effective date: 20050128