US4847091A - Pharmaceutical composition including sodium cromoglycate - Google Patents
Pharmaceutical composition including sodium cromoglycate Download PDFInfo
- Publication number
- US4847091A US4847091A US07/094,673 US9467387A US4847091A US 4847091 A US4847091 A US 4847091A US 9467387 A US9467387 A US 9467387A US 4847091 A US4847091 A US 4847091A
- Authority
- US
- United States
- Prior art keywords
- microspheres
- pharmaceutical composition
- sodium cromoglycate
- composition according
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB858529500A GB8529500D0 (en) | 1985-11-29 | 1985-11-29 | Formulation |
GB8529500 | 1985-11-29 | ||
GB868621018A GB8621018D0 (en) | 1986-08-30 | 1986-08-30 | Formulation |
GB8621018 | 1986-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
US4847091A true US4847091A (en) | 1989-07-11 |
Family
ID=26290055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/094,673 Expired - Fee Related US4847091A (en) | 1985-11-29 | 1986-11-28 | Pharmaceutical composition including sodium cromoglycate |
Country Status (3)
Country | Link |
---|---|
US (1) | US4847091A (en) |
EP (1) | EP0248051A1 (en) |
WO (1) | WO1987003197A1 (en) |
Cited By (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5254330A (en) * | 1990-01-24 | 1993-10-19 | British Technology Group Ltd. | Aerosol carriers |
US5341800A (en) * | 1989-05-31 | 1994-08-30 | Fisons Plc | Medicament inhalation device and formulation |
US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
US5837226A (en) * | 1993-12-08 | 1998-11-17 | Vitaphore Corporation C/O Integra Lifesciences Corp. | Ocular microsphere delivery system |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US6039970A (en) * | 1991-05-31 | 2000-03-21 | Fidia S.P.A. | Process for the preparation of microspheres containing biologically active components |
US6136295A (en) * | 1996-05-24 | 2000-10-24 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
WO2001076560A1 (en) * | 2000-04-11 | 2001-10-18 | Dura Pharmaceuticals, Inc. | Physically stabilized dry powder formulations |
US20010053359A1 (en) * | 1994-07-26 | 2001-12-20 | Peter Watts | Drug delivery composition for the nasal administration of antiviral agents |
US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
US20020119941A1 (en) * | 2001-02-28 | 2002-08-29 | Yawei Ni | In-situ gel formation of pectin |
US20030099711A1 (en) * | 2001-08-29 | 2003-05-29 | David Meadows | Sustained release preparations |
US6582677B1 (en) * | 1990-02-02 | 2003-06-24 | Aventis Pharmaceuticals Inc. | Propellant compositions of a particulate medicament that are free of solvents |
US20030129139A1 (en) * | 2001-11-20 | 2003-07-10 | Advanced Inhalation Research, Inc. | Particulate compositions for pulmonary delivery |
US20030129250A1 (en) * | 2001-11-20 | 2003-07-10 | Advanced Inhalation Research Inc. | Particulate compositions for improving solubility of poorly soluble agents |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US20040018243A1 (en) * | 1999-08-25 | 2004-01-29 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
US20040062718A1 (en) * | 1996-05-24 | 2004-04-01 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US20040068760A1 (en) * | 1999-11-19 | 2004-04-08 | Robl James M. | Transgenic ungulates capable of human antibody production |
US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
US20050003003A1 (en) * | 1999-08-25 | 2005-01-06 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
US20050084534A1 (en) * | 2001-02-28 | 2005-04-21 | Yawei Ni | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
US20050181050A1 (en) * | 2004-01-28 | 2005-08-18 | Collegium Pharmaceutical, Inc. | Dosage forms using drug-loaded ion exchange resins |
US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
US7048908B2 (en) | 2000-12-29 | 2006-05-23 | Advanced Inhalation Research, Inc. | Particles for inhalation having sustained release properties |
US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US20070036843A1 (en) * | 2005-01-28 | 2007-02-15 | Collegium Pharmaceutical, Inc. | Non-ionic non-aqueous vehicles for topical and oral administration of carrier-complexed active agents |
US20080008764A1 (en) * | 1994-09-30 | 2008-01-10 | Emisphere Technologies, Inc. | Carbon-substituted diketopiperazine delivery systems |
US20080227690A1 (en) * | 2000-12-29 | 2008-09-18 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US7691986B2 (en) | 1998-05-13 | 2010-04-06 | Nanotherapeutics, Inc. | High molecular weight, low methoxyl pectins, and their production and uses |
US20110171314A1 (en) * | 2006-03-30 | 2011-07-14 | Engene, Inc. | Non-viral compositions and methods for transfecting gut cells in vivo |
US9339615B2 (en) | 2008-06-13 | 2016-05-17 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9346766B2 (en) | 2004-08-20 | 2016-05-24 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
US9364436B2 (en) | 2011-06-17 | 2016-06-14 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US9446001B2 (en) | 2005-09-14 | 2016-09-20 | Mannkind Corporation | Increasing drug affinity for crystalline microparticle surfaces |
US9610351B2 (en) | 2011-10-24 | 2017-04-04 | Mannkind Corporation | Methods and compositions for treating pain |
US9630930B2 (en) | 2009-06-12 | 2017-04-25 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
US9655850B2 (en) | 2008-12-29 | 2017-05-23 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9662461B2 (en) | 2008-06-13 | 2017-05-30 | Mannkind Corporation | Dry powder drug delivery system and methods |
US9675674B2 (en) | 2004-08-23 | 2017-06-13 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US9700690B2 (en) | 2002-03-20 | 2017-07-11 | Mannkind Corporation | Inhalation apparatus |
US9706944B2 (en) | 2009-11-03 | 2017-07-18 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
US9802012B2 (en) | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US9801925B2 (en) | 1999-06-29 | 2017-10-31 | Mannkind Corporation | Potentiation of glucose elimination |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
US9943571B2 (en) | 2008-08-11 | 2018-04-17 | Mannkind Corporation | Use of ultrarapid acting insulin |
US9983108B2 (en) | 2009-03-11 | 2018-05-29 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US10130581B2 (en) | 2006-02-22 | 2018-11-20 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10342938B2 (en) | 2008-06-13 | 2019-07-09 | Mannkind Corporation | Dry powder drug delivery system |
US10421729B2 (en) | 2013-03-15 | 2019-09-24 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US10625034B2 (en) | 2011-04-01 | 2020-04-21 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
US10675421B2 (en) | 2008-06-20 | 2020-06-09 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811128A (en) * | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
GB8918879D0 (en) * | 1989-08-18 | 1989-09-27 | Danbiosyst Uk | Pharmaceutical compositions |
GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
US6126919A (en) | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3425962A (en) * | 1966-12-28 | 1969-02-04 | Bristol Myers Co | Salt of a diethylaminoethyl cross-linked dextran anion exchanger |
US4057556A (en) * | 1976-06-17 | 1977-11-08 | Ayerst, Mckenna & Harrison Ltd. | Troponyl-oxamic acid derivatives |
US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
EP0023359A2 (en) * | 1979-07-31 | 1981-02-04 | Teijin Limited | Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof |
EP0171528A2 (en) * | 1984-07-18 | 1986-02-19 | Pennwalt Corporation | Controlled release pharmaceutical preparations |
-
1986
- 1986-11-28 WO PCT/GB1986/000726 patent/WO1987003197A1/en not_active Application Discontinuation
- 1986-11-28 US US07/094,673 patent/US4847091A/en not_active Expired - Fee Related
- 1986-11-28 EP EP86906899A patent/EP0248051A1/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3425962A (en) * | 1966-12-28 | 1969-02-04 | Bristol Myers Co | Salt of a diethylaminoethyl cross-linked dextran anion exchanger |
US4057556A (en) * | 1976-06-17 | 1977-11-08 | Ayerst, Mckenna & Harrison Ltd. | Troponyl-oxamic acid derivatives |
US4221778A (en) * | 1979-01-08 | 1980-09-09 | Pennwalt Corporation | Prolonged release pharmaceutical preparations |
EP0023359A2 (en) * | 1979-07-31 | 1981-02-04 | Teijin Limited | Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof |
EP0171528A2 (en) * | 1984-07-18 | 1986-02-19 | Pennwalt Corporation | Controlled release pharmaceutical preparations |
Cited By (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5341800A (en) * | 1989-05-31 | 1994-08-30 | Fisons Plc | Medicament inhalation device and formulation |
US5538999A (en) * | 1989-05-31 | 1996-07-23 | Fisons Plc | Medicament inhalation device and formulation |
US5628307A (en) * | 1989-05-31 | 1997-05-13 | Fisons Plc | Medicament inhalation device and formulation |
US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
US5804212A (en) * | 1989-11-04 | 1998-09-08 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
US5376386A (en) * | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
US5254330A (en) * | 1990-01-24 | 1993-10-19 | British Technology Group Ltd. | Aerosol carriers |
US6582677B1 (en) * | 1990-02-02 | 2003-06-24 | Aventis Pharmaceuticals Inc. | Propellant compositions of a particulate medicament that are free of solvents |
US6039970A (en) * | 1991-05-31 | 2000-03-21 | Fidia S.P.A. | Process for the preparation of microspheres containing biologically active components |
US6066340A (en) * | 1991-05-31 | 2000-05-23 | Fidia S.P.A. | Process for the preparation of microspheres containing biologically active components |
US5837226A (en) * | 1993-12-08 | 1998-11-17 | Vitaphore Corporation C/O Integra Lifesciences Corp. | Ocular microsphere delivery system |
US20010053359A1 (en) * | 1994-07-26 | 2001-12-20 | Peter Watts | Drug delivery composition for the nasal administration of antiviral agents |
US20080008764A1 (en) * | 1994-09-30 | 2008-01-10 | Emisphere Technologies, Inc. | Carbon-substituted diketopiperazine delivery systems |
US6399102B1 (en) | 1996-05-24 | 2002-06-04 | The Penn State Research Foundation | Aerodynamically light particles for pulmonary drug delivery |
US20050158249A1 (en) * | 1996-05-24 | 2005-07-21 | Edwards David A. | Aerodynamically light particles for pulmonary drug delivery |
US20040047811A1 (en) * | 1996-05-24 | 2004-03-11 | The Penn State Research Foundation | Aerodynamically light particles for pulmonary drug delivery |
US20080253971A9 (en) * | 1996-05-24 | 2008-10-16 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US7628977B2 (en) | 1996-05-24 | 2009-12-08 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US6942868B2 (en) | 1996-05-24 | 2005-09-13 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US20040062718A1 (en) * | 1996-05-24 | 2004-04-01 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US6635283B2 (en) | 1996-05-24 | 2003-10-21 | Penn State Res Found | Aerodynamically light particles for pulmonary drug delivery |
US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
US6136295A (en) * | 1996-05-24 | 2000-10-24 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US6391452B1 (en) | 1997-07-18 | 2002-05-21 | Bayer Corporation | Compositions for nasal drug delivery, methods of making same, and methods of removing residual solvent from pharmaceutical preparations |
US7052678B2 (en) | 1997-09-15 | 2006-05-30 | Massachusetts Institute Of Technology | Particles for inhalation having sustained release properties |
US20070014738A1 (en) * | 1997-09-15 | 2007-01-18 | Edwards David A | Particles for inhalation having sustained release properties |
US7691986B2 (en) | 1998-05-13 | 2010-04-06 | Nanotherapeutics, Inc. | High molecular weight, low methoxyl pectins, and their production and uses |
US7705135B2 (en) | 1998-05-13 | 2010-04-27 | Nanotherapeutics, Inc. | Pharmaceutical compositions comprising aloe pectins, and methods for their production and use |
US20060002996A1 (en) * | 1998-08-25 | 2006-01-05 | Edwards David A | Stable spray-dried protein formulations |
US6956021B1 (en) | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
US9801925B2 (en) | 1999-06-29 | 2017-10-31 | Mannkind Corporation | Potentiation of glucose elimination |
US20050003003A1 (en) * | 1999-08-25 | 2005-01-06 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
US6749835B1 (en) | 1999-08-25 | 2004-06-15 | Advanced Inhalation Research, Inc. | Formulation for spray-drying large porous particles |
US20040018243A1 (en) * | 1999-08-25 | 2004-01-29 | Advanced Inhalation Research, Inc. | Modulation of release from dry powder formulations |
US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
US20040068760A1 (en) * | 1999-11-19 | 2004-04-08 | Robl James M. | Transgenic ungulates capable of human antibody production |
WO2001076560A1 (en) * | 2000-04-11 | 2001-10-18 | Dura Pharmaceuticals, Inc. | Physically stabilized dry powder formulations |
US20080227690A1 (en) * | 2000-12-29 | 2008-09-18 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
US7048908B2 (en) | 2000-12-29 | 2006-05-23 | Advanced Inhalation Research, Inc. | Particles for inhalation having sustained release properties |
US20080039366A1 (en) * | 2000-12-29 | 2008-02-14 | Advanced Inhalation Research | Particles for inhalation having sustained release properties |
US20050084534A1 (en) * | 2001-02-28 | 2005-04-21 | Yawei Ni | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
US20020119941A1 (en) * | 2001-02-28 | 2002-08-29 | Yawei Ni | In-situ gel formation of pectin |
US6777000B2 (en) | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
US7494669B2 (en) | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
US20030099711A1 (en) * | 2001-08-29 | 2003-05-29 | David Meadows | Sustained release preparations |
US20030129139A1 (en) * | 2001-11-20 | 2003-07-10 | Advanced Inhalation Research, Inc. | Particulate compositions for pulmonary delivery |
US7384649B2 (en) | 2001-11-20 | 2008-06-10 | Advanced Inhalation Research, Inc. | Particulate compositions for pulmonary delivery |
US20030129250A1 (en) * | 2001-11-20 | 2003-07-10 | Advanced Inhalation Research Inc. | Particulate compositions for improving solubility of poorly soluble agents |
US20070104657A1 (en) * | 2001-11-20 | 2007-05-10 | Batycky Richard P | Particulate compositions for pulmonary delivery |
US7182961B2 (en) | 2001-11-20 | 2007-02-27 | Advanced Inhalation Research, Inc. | Particulate compositions for pulmonary delivery |
US9700690B2 (en) | 2002-03-20 | 2017-07-11 | Mannkind Corporation | Inhalation apparatus |
US20050181050A1 (en) * | 2004-01-28 | 2005-08-18 | Collegium Pharmaceutical, Inc. | Dosage forms using drug-loaded ion exchange resins |
US20050265955A1 (en) * | 2004-05-28 | 2005-12-01 | Mallinckrodt Inc. | Sustained release preparations |
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Also Published As
Publication number | Publication date |
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WO1987003197A1 (en) | 1987-06-04 |
EP0248051A1 (en) | 1987-12-09 |
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