|Publication number||US3918451 A|
|Publication date||11 Nov 1975|
|Filing date||16 Sep 1974|
|Priority date||18 Sep 1973|
|Also published as||CA1027448A, CA1027448A1, DE2346914A1, DE2346914B2, DE2346914C3|
|Publication number||US 3918451 A, US 3918451A, US-A-3918451, US3918451 A, US3918451A|
|Original Assignee||Ritzau Pari Werk Kg Paul|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (2), Referenced by (58), Classifications (8), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [191 Steil INHALATOR FOR PULVERULENT SUBSTANCES  Inventor: Emeram Steil, Starnberg, Germany  Assignee: Paul Ritzau Pari-Werk KG, Germany  Filed: Sept. 16, 1974  Appl. N0.: 506,611
 Foreign Application Priority Data Sept. 18, 1973 Germany 2346914  US. Cl. 128/260; 128/208; 222/193  Int. Cl.? B67D 5/54; A61M 13/00;
A61M 15/06  Field of Search 128/266, 208; 222/193  References Cited UNITED STATES PATENTS 3,635,219 l/1972 Collingwood 128/208 X 3,870,046 3/1975 Elliott 128/266 Prinmr Examiner-Aldrich F. Medbery Attorney, Agent, or Firm-Hill, Gross, Simpson, Van Santen, Steadman, Chiara & Simpson [5 7] ABSTRACT An inhalator the case of which is provided with a reception space in its outer peripheral surface for insertably carrying a capsule containing a substance to be inhaled. An outer cover is mounted on the case and is movable with respect to the case between specified positions under the action of a spring bias. In one position the cover exposes the reception space to permit insertion and removal of capsules at which position the cover is interlocked with the case. Upon insertion of a capsule the cover is automatically unlocked from the case and moves under the spring bias to a position to cover the capsule and to a further position at which cutting members coupled to the cover move into the reception space to open the capsule.
18 Claims, 4 Drawing Figures US. Patent Nov. 11, 1975 Sheet1of2 3,918,451
INHALATOR FOR PULVERULENT SUBSTANCES The invention relates to an inhalator for pulverulent substances contained in capsules insertible into themhalator case, with an inlet and an outlet forthe respiratory air. An inhalator of this type, which is applied in medicine for example, is already known. It offers the advantage that, by the insertion of a capsule, a precisely dosed quantity of the substance which is to be inhaled is present within the apparatus, so that when it is needed, e.g. during acute asthmatic attacks, no harmful excess dosage can be inhaled. It is handy moreover, and may easily be stowed inside a pocket.
The inhalator of the kind described in the foregoing is so formed that the capsule is pushed into a rotatably installed cylindrical sleeve which may be placed in wobbling rotary motion when a flow of air is drawn through a suction via the mouthpiece installed on the apparatus, by means of' propeller blades arranged thereon. The pulverulent substance present within the previously pierced capsule is concomitantly raised from the latter by turbulence, whereupon it penetrates the patients mouth via the mouthpiece, together with the air sucked in. It is a disadvantage of this apparatus, that it must be disassembled into three parts when fitting each capsule, and that it must be serviced approximately once a week, i.e. dismantled, cleaned and oiled. The reliability is inadequate moreover, so that the makers recommend that a replacement apparatus be kept in readiness at all times. The object of the present invention is'to eliminate these disadvantages and to provide an uncomplicated and reliably operated inhalator, which is handy, requires no maintenance and is reliable. In accordance withthe invention, this problem is resolved in that the capsule reception space is situated at the periphery of the case with aside open at the periphery and is equipped with a cover movably arranged thereon, and which uncovers the capsule reception space in a filling and emptying position and covers it in another position. This cover may be rotatably arranged, and may comprise an aperture acting as a passage for traversal by the capsule. The cover may be stopped at the filling and emptying position by means ofa stop pin guided in longitudinally displaceable manner with respect to a notch of the cover. This stop pin may have connected to it an ejector for capsules present within the reception space, in such manner that it is insertable into the reception space under the force of a spring and at the same time moves the stop pin into the notch of the cover. During the pressing ofa capsule into the reception space, the ejector and the stop pin are then pushed into the inside of the case, the latter concomitantly cancelling the immobilisation. A spring member may then automatically move the cover into the idle position. The cover may be equipped with a device for opening capsules, for example in the form of two small blades, which under a force acting against the spring as described in the foregoing, may be pushed into the reception space of the capsule. The covermay be formed in a variety of ways, e.g. as a cylindrical sleeve partially surrounding the apparatus, as a slider, or as a removable lid. The cover is preferably produced in transparent form, so that the blades and capsule remain permanently visible, in order to show whether a new unopened capsule has been inserted.
According to the invention therefore there is provided an inhalator for pulverulent substances comprising an inhalator case having an inlet and an outlet for passing respiratory air, a reception space formed on the outer periphery of the case for insertably receiving a capsule containing a pulverulent substance, means for mounting a cover portion on the inhalator case for movement with respect thereto between a first position whereat the cover portion encloses the capsule in the reception space and a second position at which the cover portion uncovers the capsule in the reception space to permit removal and replacement thereof.
The advantages of the present invention consist in that as a consequence of the incorporation of the capsule reception space at the periphery of the case, in combination with a removable cover, a new capsule may be inserted without dismantling the case. The spring arrangement of the cover has the result that the cover moves automatically to the idle position and thus eliminates confusion between the opening and the idle or operating positions, which exists in the known systems. The ejector arranged under spring loading considerably simplifies the handling of the apparatus. The omission of a turbo impeller wheel simplifies the operation and improves the reliability of the apparatus.
The invention will be better understood from the following description taken with reference to the drawings wherein:
-FIG. 1 shows an overall view of the apparatus in the operating or idle position,
FIG. 2 shows a cross-section of the apparatus in the filling and emptying position, along the line IIII in FIG. 1,
FIG. 3 shows a cross-section of the apparatus in the operating or idle position, along the line IIIIII in FIG.
FIG. 4 shows a cross-section of the apparatus in the pricking-open position, along the line IIIIII in FIG. I.
With reference to the drawings an inhalator comprises a cylindrical case 2 and is equipped with a mouth piece 17 at its one terminal extremity. An aperture 4 of a cover 3 may be brought into the filling and emptying position shown in FIG. 2, against the spring force of a spring member 16. A stop pin 6 which is guided within the case in a perforation 7 and rigidly coupled to an ejector 10 is then pushed into a then available notch 8 of the cover 3 as a consequence of the spring force of another spring member 9, and immobilises the cover. In this position, a capsule 11 may be pushed into a reception space 1 of the inhalator against the ejector I0 projecting into the same, in such manner that the stop pin coupled to it is released at the same time, the cover 3 concomitantly being displaced by means of the spring member 16 shown in FIG. 1 into an idle and operating position, in which the capsule 11 is covered by the cover 3 within the outwardly open peripherally situated reception space 1.
By moving the cover 3 in a direction away from the filling and emptying position, a cutting device comprising two small blades 12, fastened on the cover 3 and guided in slots 18 of the case, engages the reception space 1 and cuts or pricks two small holes 13 into the capsule l1 situated therein, close to the two extremities of the capsule. The blades 12 movable in slots 18 incorporated along the periphery simultaneously act as axial bearers for the cylindrical sleeve of the case, which is constructed as a cover. The pricking-open position of the inhalator is shown in FIG. 4.
As a consequence of the spring force of the spring member 16, acting at two sides, the cover 3 is moved automatically into the idle and operating position after it has been released. During inhalation, the pulverulent substance present within the capsule 11 is sucked into the mouth as a consequence of the holes 13, via the mouthpiece 17, an inlet opening 14 connected to the reception space 1 and an outlet opening which is open towards the mouthpiece 17, as illustrated in FIG. 1. To eject the empty capsule 11, the cover 3 is brought into the filling and emptying position against the spring force of the spring member 16, the stop pin 6 and the ejector 10 then being moved towards as a consequence of the spring force of the spring member 9, and the ejector ejects the capsule automatically.
The bottom of the inhalator, which is not shown in the drawings, is equipped with air entry slots for the inlet opening 14 and is inset into the cylindrically formed cover 3, may be constructed in pot-like form close to the axis and may be equipped with a groove in order to act as a receptor and partially as an entraining element for the spring member 16. The cover 3 is transparent thus making it possible to ascertain directly whether a fresh unopened capsule has been inserted. Moreover, it becomes immediately apparent whether the cover 3 is being displaced in the right direction.
In another example of an embodiment which is not illustrated, the cover may be constructed as a closed slide matching the shape of the case. This slider may be displaced either in the direction along the periphery or in axially parallel direction.
In another example of an embodiment which is not illustrated, the cover may also be made in the form of a lid which is removable or secured by hinges.
1. An inhalator for pulverulent substances comprising an inhalator case having an inlet and an outlet for passing respiratory air, a reception space formed on the outer periphery of the case for insertably receiving a rupturable capsule containing a pulverulent substance, means for mounting a cover portion on the inhalator case for movement with respect thereto between a first position whereat the cover portion encloses the capsule in the reception space and a second position at which the cover portion uncovers the capsule in the reception space to permit removal and replacement thereof.
2. An inhalator as claimed in claim 1, wherein said means for mounting the cover portion is rotatable. and is arranged on the outer surface of said inhalator case, said cover portion having an aperture for traversal by the capsule from and to said reception space.
3. An inhalator as claimed in claim 1, wherein a stop pin is guided in a longitudinal displaceable manner within said case and a notched portion is provided in said cover portion so that in said second position of the cover portion the stop pin engages the notched portion and immobilises the cover portion in said second position.
4. An inhalator as claimed in claim 3, wherein an ejector member rigidly coupled to said stop pin is displaceably arranged within the inhalator case, and first spring means is coupled to the ejector means to constantly urge the ejector member to eject a capsule from the reception space, and concomitantly move said stop pin into the notched portion of the cover portion whereby during insertion of a capsule into the reception space, the ejector member is moved out of the reception space against the force of said spring means, the stop pin concomitantly cancelling said immobilisation of said cover portion.
5. An inhalator as claimed in claim 1, further comprising opening means to open a capsule in the reception space, said opening means being mounted to said cover portion to be moved together therewith into said reception space.
6. An inhalator as claimed in' claim 5, wherein said opening means comprises two blades which cut the capsule open vicinal to its extremities.
7. An inhalator as claimed in claim 6, wherein said means for mounting said cover portion on the inhalator case for movement with respect thereto includes a spring member under the biasing force of which said cover portion is moved from said first position, into said second position and also into a third position at which said opening means enters said reception space.
8. An inhalator as claimed in claim 1, wherein said reception space communicates with the inside of the inhalator case via an air inlet and an air outlet opening.
9. An inhalator as claimed in claim 8, wherein the blades of said opening means are moved into the reception space through said air inlet and air outlet openings.
10. An inhalator as claimed in claim 9, wherein the blades of said opening means are movable in slots of the walls of said inhalator case.
1 1. An inhalator as claimed in claim 10, wherein said cover portion is held in an axial direction on the inhalator case by the blades engaging said slots.
12. An inhalator as claimed in claim 1, wherein said inhalator case is cylindrical and said cover portion is mounted for slidable movement therearound.
13. An inhalator as claimed in claim 12, wherein said cover portion is a cylindrical sleeve partially surrounding the inhalator case. i
14. An inhalator as claimed in claim 13, wherein said cylindrical sleeve has a base which surmounts the inhalator case at one end thereof.
15..An inhalator as claimed in claim 14, wherein said spring member is a spring coil, a stud member being provided on the base of said sleeve to seat the coil spring which engages co-axially in the case.
16 An inhalator as claimed in claim 15, wherein said coil spring is seated on the base of the sleeve in a pot engaging in the case and with its extremities protruding radially in limb-like manner is engaged through an opening in the side wall of the pot and into a recess in the wall of the inhalator case.
17. An inhalator as claimed in claim 1, wherein said cover portion is removable.
18. An inhalator as claimed in claim 1, wherein said cover portion is transparent.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3635219 *||4 Jun 1969||18 Jan 1972||Fisons Pharmaceuticals Ltd||Inhalation device|
|US3870046 *||22 Apr 1974||11 Mar 1975||Miles Lab||Insufflator|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4013075 *||15 Jul 1975||22 Mar 1977||I.S.F. S.P.A.||Inhalers and insufflators having a cutting means|
|US4117844 *||10 Feb 1977||3 Oct 1978||Allen & Hanburys Limited||Device for dispensing medicaments|
|US4860740 *||10 Feb 1987||29 Aug 1989||Riker Laboratories, Inc.||Powder inhalation device|
|US4889114 *||2 Jul 1987||26 Dec 1989||Boehringer Ingelheim Kg||Powdered pharmaceutical inhaler|
|US5048514 *||3 Jul 1990||17 Sep 1991||Somova S.P.A.||Inhaler for medicaments contained in capsules|
|US5152284 *||24 May 1991||6 Oct 1992||Phidea S.P.A.||Disposable inhaler with pre-pierced capsule|
|US5320095 *||10 Dec 1991||14 Jun 1994||Pharmachemie B.V.||Device for use with the inhalation of powdered materials contained in rod-shaped capsules|
|US5476093 *||14 Jul 1993||19 Dec 1995||Huhtamaki Oy||Device for more effective pulverization of a powdered inhalation medicament|
|US5483954 *||10 Jun 1994||16 Jan 1996||Mecikalski; Mark B.||Inhaler and medicated package|
|US5505194 *||4 Oct 1994||9 Apr 1996||Abbott Laboratories||Aerosol inhalation device having slideably and rotatably connected elliptical cylinder portions|
|US5568807 *||13 Jul 1995||29 Oct 1996||Mecikalski; Mark B.||Air-flow control for an inhaler|
|US5575281 *||13 Jul 1995||19 Nov 1996||Mecikalski; Mark B.||Medicated package|
|US5584285 *||7 Jun 1995||17 Dec 1996||Salter Labs||Breathing circuit apparatus for a nebulizer|
|US5619985 *||3 Aug 1995||15 Apr 1997||Unisia Jecs Corporation||Inhaler type medicine administering device|
|US5647349 *||31 May 1996||15 Jul 1997||Unisia Jecs Corporation||Medicine administering inhaling device|
|US5690101 *||30 Jul 1996||25 Nov 1997||Kutta; Helmuth W.||Portable air purifier with chemical reaction zone|
|US5752505 *||18 Mar 1997||19 May 1998||Unisia Jecs Corporation||Inhalation-type medicine delivery device|
|US6089228 *||8 Jan 1998||18 Jul 2000||Inhale Therapeutic Systems||Apparatus and methods for dispersing dry powder medicaments|
|US6257233||14 May 1999||10 Jul 2001||Inhale Therapeutic Systems||Dry powder dispersing apparatus and methods for their use|
|US6470884||16 Apr 2001||29 Oct 2002||Aventis Pharma Limited||Capsule opening arrangement for use in a powder inhaler|
|US6543448||30 May 2000||8 Apr 2003||Inhale Therapeutic Systems, Inc.||Apparatus and methods for dispersing dry powder medicaments|
|US6546929||4 Jun 2001||15 Apr 2003||Inhale Therapeutic Systems, Inc.||Dry powder dispersing apparatus and methods for their use|
|US6575160||7 Sep 2000||10 Jun 2003||Art Slutsky||Inhalation device|
|US6679255 *||28 Feb 2002||20 Jan 2004||Ivo E. Pera||Inhaling device for dispensing powdered medicaments contained in a capsule through the respiratory tract|
|US6679256||6 Dec 2000||20 Jan 2004||Nektar Therapeutics||Systems and methods for extracting powders from receptacles|
|US6681767||1 May 2000||27 Jan 2004||Nektar Therapeutics||Method and device for delivering aerosolized medicaments|
|US6705313 *||9 May 2002||16 Mar 2004||Ph&T S.P.A.||Device usable in the treatment of affections of the airways|
|US6901929||19 Dec 2002||7 Jun 2005||Nektar Therapeutics||Dry powder dispersing apparatus and methods for their use|
|US7284553 *||4 Dec 2003||23 Oct 2007||Boehringer Ingelheim Pharma Gmbh & Co. Kg||Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient|
|US7422013||9 Mar 2005||9 Sep 2008||Nektar Therapeutics||Dry powder dispersing apparatus and methods for their use|
|US7559325 *||9 Apr 2004||14 Jul 2009||Novartis Pharma Ag||Aerosolization apparatus with air inlet shield|
|US8006695||10 Nov 2005||30 Aug 2011||Cipla Limited||Inhaler|
|US8069851 *||22 Jun 2009||6 Dec 2011||Novartis Ag||Aeorosolization apparatus with air inlet shield|
|US8123082||22 Jan 2008||28 Feb 2012||McNeil-AB||Hand-held dispensing device|
|US8161969||21 Mar 2008||24 Apr 2012||Novartis Ag||Dry powder dispersing apparatus and methods for their use|
|US8539947 *||17 Jul 2008||24 Sep 2013||Boehringer Ingelheim International Gmbh||Powder inhaler|
|US8869794||9 Apr 2004||28 Oct 2014||Novartis Pharma Ag||Aerosolization apparatus with capsule puncturing member|
|US20030131847 *||9 May 2002||17 Jul 2003||Fabrizio Niccolai||Device usable in the treatment of affections of the airways|
|US20030209243 *||19 Dec 2002||13 Nov 2003||Inhale Therapeutic Systems||Dry powder dispersing apparatus and methods for their use|
|US20040149283 *||4 Dec 2003||5 Aug 2004||Boehringer Ingelheim Pharma Gmbh & Co. Kg||Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient|
|US20040206350 *||14 Nov 2003||21 Oct 2004||Nektar Therapeutics||Aerosolization apparatus with non-circular aerosolization chamber|
|US20050150492 *||9 Apr 2004||14 Jul 2005||Nektar Therapeutics||Aerosolization apparatus with air inlet shield|
|US20050279349 *||24 Oct 2003||22 Dec 2005||Patton John S||Method and device for delivering aerosolized medicaments|
|US20060151536 *||22 Dec 2003||13 Jul 2006||Acrux Ddspty Ltd||Dispensing device|
|US20080105256 *||10 Nov 2005||8 May 2008||Cipla Limited||Inhaler|
|US20080230058 *||21 Mar 2008||25 Sep 2008||Nektar Therapeutics||Dry powder dispersing apparatus and methods for their use|
|US20090183744 *||22 Jan 2008||23 Jul 2009||Paul Graham Hayton||Hand-Held dispensing device|
|US20090211576 *||2 Oct 2008||27 Aug 2009||Timo Lehtonen||Safety and abuse deterrent improved device|
|US20090260623 *||22 Jun 2009||22 Oct 2009||Novartis Pharma Ag||Aeorosolization apparatus with air inlet shield|
|US20100275917 *||17 Jul 2008||4 Nov 2010||Boehringer Ingelheim International Gmbh||Powder inhaler|
|DE3927170A1 *||17 Aug 1989||21 Feb 1991||Boehringer Ingelheim Kg||Inhalator|
|EP1082155A2 *||19 May 1999||14 Mar 2001||Inhale Therapeutic Systems||Dry powder dispersing apparatus and methods for their use|
|EP1941868A2||26 Feb 2001||9 Jul 2008||PharmaKodex Limited||Improvements in or relating to the delivery of oral drugs|
|WO1991002558A1 *||14 Aug 1990||7 Mar 1991||Boehringer Ingelheim Kg||Inhalator|
|WO1999062495A3 *||19 May 1999||10 Feb 2000||Inhale Therapeutic Syst||Dry powder dispersing apparatus and methods for their use|
|WO2004056413A1 *||22 Dec 2003||8 Jul 2004||Acrux Dds Pty Ltd||Dispensing device|
|WO2006051300A1 *||10 Nov 2005||18 May 2006||Cipla Limited||Inhaler|
|WO2006066363A1 *||23 Dec 2005||29 Jun 2006||Acrux Dds Pty Ltd||Dispensing device|
|International Classification||A61M13/00, A61M15/00|
|Cooperative Classification||A61M2015/0033, A61M15/0028, A61M2015/004, A61M2202/064|
|24 Oct 1984||AS02||Assignment of assignor's interest|
Owner name: PAUL RITZAU PARI-WERK KG A GERMAN CORP
Effective date: 19841008
Owner name: STARNBERG A CORP. OF GERMANY
|24 Oct 1984||AS||Assignment|
Owner name: STARNBERG A CORP. OF GERMANY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:PAUL RITZAU PARI-WERK KG A GERMAN CORP;REEL/FRAME:004326/0823
Effective date: 19841008