|Publication number||US3907389 A|
|Publication date||23 Sep 1975|
|Filing date||12 Dec 1973|
|Priority date||12 Dec 1973|
|Publication number||US 3907389 A, US 3907389A, US-A-3907389, US3907389 A, US3907389A|
|Inventors||Cox Marion E, Cox Mary E|
|Original Assignee||Cox Marion E, Cox Mary E|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (150), Classifications (21), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent  Cox et al.
[ 1 Sept. 23, 1975 GLOVE BOX CHAMBER  Inventors: Marion E. Cox; Mary E. Cox, both of 10337 Glencoe, Cupertino, Calif.
22 Filed: Dec. 12, 1973 21 Appl. No.: 426,672
 US. Cl. 312/1; 128/1 R; 128/1 B  Int. Cl. A61G 11/00  Field of Search 23/259; 128/1 R, l B; 312/1  References Cited UNITED STATES PATENTS 2,244,082 6/1941 Reyniers 128/1 B 2,720,387 10/1955 Dorsak 128/1 B X 2,786,740 3/1957 Taylor et a1 128/1 B X 3,187,744 6/1965 Dorsak 128/1 B 3,335,713 8/1967 Grosholz 128/1 B Primary ExaminerJames C. Mitchell Attorney, Agent, or FirmC. Michael Zimmerman, Esq.
[ ABSTRACT An environmental chamber is described which enables an operators hands to have direct access within the chamber without compromising a special atmosphere within such chamber. A pair of sleeves of a flexible material are sealed to the chamber around associated access apertures and project outwardly from such chamber. Each aperture is closed by a door which is openable from within the sleeve associated therewith so that upon an operator inserting his hand and arm through the sleeve, the operator can open the door to have access to the interior of the chamber. A container which is selectively separable from the remainder of the chamber is also provided to allow objects to be transferred from the chamber without such objects having to pass through the ambient atmosphere, and an antechamber permitting objects to be passed directly into the chamber from the ambient atmosphere is included.
16 Claims, 9 Drawing Figures as as US Patent Sept. 23,1975 Sheet 1 of 3 3,907,389
US Patent Sept. 23,1975 Sheet 2 01 3 3,907,389
Sheet 3 of 3 Sept. 23,1975
US Patent GLOVE Box CHAMBER BACKGROUND OF THE INVENTION The present invention relates to a chamber for maintaining an object within an isolated environment and, more particularly, to such a chamber which facilitates hand manipulation of an object so maintained from the exterior of the chamber, as. well as passage of the object into or out of the chamber without deleterious contamination from. the surrounding atmosphere.
Small environment isolation chambers or, as they are more commonly called, :glove boxes, are extensively used in research, industry and medicineto. facilitate the hand manipulation of an object of one sort or another within an isolated environment. For example, glove boxes are used in clinical laboratories in connection with the culturing of anaerobic bacteria in an oxygen free atmosphere. To enable. manipulation of the object within the chamber, rubber gloves are normally provided projecting into the chamber enclosure with their sleeve ends sealed around an opening through a wall of such enclosure. The gloves provide, in effect, aycontinuation of the chamber enclosure wall and separate not only an operators hands extended through the opening from the interior of the enclosure, but also prevent the ambient atmosphere from entering into;the enclosure through such opening. 1 t
The rubber gloves normally have relatively thick walls in order to increase their life and reduce the chances of a leak through them. However, as will be recognized, such thickness reduces the feel which an operator can have through the gloves for objects within the enclosure, as well as the operators manual dexterity. Moreover, glove leaks often occur, especially in old gloves, in spite of the thickness, due to the continual flexing of the glove material and the careless handling of Sharp instruments or the like within the enclosure.
Most conventional glove boxes are also deficient in the manner provided for introducing or removing .objects or specimens from the same. For example, typical laboratory glove boxes include a pass-through or preaccess chamber having both a door to the exterior and a door to the main chamber enclosurefor this purpose. An object to be introduced into the chamber enclosure is first placed within the pass-through enclosure and then the desired special atmosphere introduced into such passthrough enclosurebefore communication is provided between the same and the main chamber enclosure. While this procedure will assure that none of theambient atmosphere is allowed to enter the main chamber enclosure, it does not provide any protection for the object or specimen before it enters the passthrough enclosure. Moreover, the removal of an undesired atmosphere from the pass-through enclosure prior to its communication with the main chamber is often a time-consuming operation.
sUMM'ARY OF THE INVENTION not contaminated by the surrounding atmosphere. Tothis end, the chamber includes, as is'usual, an enclosure" for separating the object from the surrounding atmo'- sphere. At least one access port is provided into the en"- closure enabling admission of the hand of an operator for the desired manipulation. The access port includes adoor which seals the aperturein the wall of the chamber through which the operators hand is extendable, and a sleeve which is sealed to such enclosure in communication with the aperture. In keeping with the invention, a free end portion of the sleeve extends to the exterior of the enclosure and provides a pre-access chamber for separating the hand of the operator from the ambient atmosphere prior to the opening of' the door for access of such handinto the enclosure. Most simply, such sleeve is one of an elastic material, such as latex, which sealingly engages or grips the arm of the operator to define the pre-access chamber. In this con-' nection, means are most desirably provided for evacuating the pre-access chamber prior to the door opening.
As another feature of the chamber of the invention,- it further includes means for transferring a desired ob- I ject between the chamber and a container therefor without opening either such container or the chamber enclosure to the atmospherefTo this end, the chamber enclosure includes an access opening through its wall over which is positionable, which a slide cover slide cover is guided by slide guides along a path traversing the opening between. a closed position in which such openingiscovered and an open position in which it is exposed. The; container to which the object is to be transferred also includes an access opening within a wall thereof which includes slide guides complementary to the slide guides on the main enclosure to guide such container wall across the enclosure access opening to replace the slide cover thereover when the slide cover is moved to its open position. Such container wall thus closes the enclosure opening'and provides access between the enclosure opening and its own access opening. Most desirably, the cover over the container opening is sized to fit through the enclosure opening so that such coveris removable from the interior of the main chamber enclosure to enable the container and chamber to be simply communicated, without the container cover having to be removed from the container when the container opening is exposed to the ambient atmosphere. Thus, an object is movable between the closure in order to obtain a desired gas reduction is reduced.
The invention includes other features and advantages which will be described or will become apparent from the following more detailed description of a preferred embodiment.
BRIEF DESCRIPTION ()FTHE DRAWINGS With'referenceto: the accompanying three sheets of ,drawings:
FIG. -l is an overall perspective view illustrating a preferred embodiment of the isolation chamber of the invention;
FIG. 2 is a partial and broken-away elevation view of the access port providing a pre-access chamber for the hand of an operator to be introduced into the chamber;
FIGS. 3 and 4 are elevation views, taken on planes indicated by the lines 3-3 and 44 in FIG. 2, respectively;
FIG. 5 is a partial view similar to FIG. 2 illustrating the access port of the invention with an operators hand within the pre-access chamber defined thereby;
FIG. 6 is an elevation view similar to FIG. 5 but illustrating the operators hand gaining access to the interior of the main chamber;
FIG. 7 is a partial perspective view illustrating the communication of a container for an object with the main chamber; and
FIGS. 8 and 9 are generally schematic, broken away perspective and elevation views, respectively, of the pass-through for the chamber of the invention.
DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT With reference to the accompanying drawing, FIG. 1 is an overall perspective view of a chamber, generally referred to by the reference numeral 11, of the invention for defining an isolated environment for an object. As'is illustrated, such chamber includes a main, gastight enclosure 12 for separating an object to be maintained in an isolated environment from the ambient atmosphere. Although the material providing the walls of the enclosure 12 is not critical, most desirably such material is transparent, such as of a clear rigid plastic, to facilitate an operator observing manipulations within the interior of such enclosure.
Means are provided for introducing a desired atmosphere into the enclosure 12. More particularly, such enclosure is communicated via a nipple l3 and tubular line 14 with a three-way valve 16 in a valve manifold 17. The input to such valve manifold is provided through line 18 to a source (not shown) of vacuum, and through line 19 to a source (also not shown) of a desiredgas or gas mixture. Valve 16 is similar to the other valves in the valve manifold in that it has a first position in which it communicates the vacuum source with the enclosure, a second position in which it communicates the gas supplied by line 19 with the enclosure, and a third position in which it closes line 14. The other valves within the manifold are communicated through suitable lines with other components of the chamber as will be described hereinafter.
In accordance with conventional practice, it is desirable to maintain the pressure within the enclosure 12 slightly above the surrounding pressure so that if there are any small leaks in the chamber, leakage flow will be from the interior of the chamber to the exterior, rather than vice versa. The result is that the likelihood of contamination of the chamber due to a small leak is avoided.
As a particularly salient feature of the instant invention, it includes a pair of access ports which enable an operator to insert both of his hands into the interior of the enclosure for manipulating an object therein, without opening the enclosure to the ambient atmosphere. The invention accomplishes this without requiring the use of rubber gloves with their inherent disadvantages as discussed above. More particularly, a pair of access ports 21 and 22 are provided in the front wall 23 of the enclosure, which access ports are positioned to facilitate admission into the chamber of an operators right and left hands, respectively. Such access ports are essentially identical, and only one of the same, access port 22, will be described in detail.
With reference to FIGS. 1 through 6, it will be seen that the access port 22 includes a circular aperture 24 through enclosure wall 23, which aperture is closed or sealed by a circular door plate 26. In this connection, the door plate has a diameter greater than that of the aperture 24 so that the peripheral edge of such plate will overlap the aperture and provide an annular surface area which engagesthe interior surface of the wall 23 for sealing thereagainst. An O-ring 27 assures that such seal is a gas-tight seal.
Locking means manipulatable from the exterior of the enclosure are provided for opening the door 26. That is, a latch bar 28 is pivotally mounted centrally of the exterior side of the door by a bolt 29 which freely passes therethrough. As is illustrated, a wing nut 31 is on the threaded end of such bolt on the exterior side of the door. As is best illustrated in FIGS. 3 and 4, the length of the latch bar 28 is greater than the diameter of the aperture 24 so that the wall 23 can be sandwiched between the door plate and the latch bar as illustrated to provide a tight seal around the periphery of such aperture. However, the aperture is provided with opposed notches 32 through which the ends of the latch bar 28 will fit to enable removal of the door into the interior of the enclosure 12.
A sleeve 33 of a gas impermeable, flexible material has one end sealed to the enclosure in communication with the aperture 24. More particularly, an annular flange 34 is provided on the exterior side of the wall 23 projecting outwardly therefrom and circumscribing aperture 24. As is illustrated, one end of the sleeve 33 is fitted around the flange 34 and is tightly and sealingly held in position by an adjustable ring clamp 36. The sleeve 33 thus provides, in effect, a flexible extension of the flange 34.
In keeping with the invention, the sleeve 33 projects outwardly from the enclosure 12 and terminates in a free end portion 37. Such free end portion provides a pre-access chamber for separating the hand of an operator from the ambient atmosphere prior to the opening of the door 26 for access of such hand into the enclosure. In this connection, the sleeve end portion 29 is most desirably of a highly elastic, as well as flexible, material such as latex rubber and has a diameter which assures that it sealingly engages the arm of an operator inserted therethrough toward the enclosure. Such construction of the sleeve will assure that it automatically provides a gas-tight seal about the arm of an operator inserted therein, without requiring a clamp or other structure providing a seal between the operators arm and the sleeve end portion.
Means are provided for evacuating the pre-access chamber defined by the sleeve of its ambient pressure prior to the opening of the door 26 for access of an operators hand into the enclosure 12. That is, a threeway valve 38 in manifold 17 is communicated with a nipple 39 in flange 34 via a tubular line 41. The valve 38 enables communication of the interior of the sleeve 33 with the vacuum source, in order to remove ambient atmosphere therefrom. Because of the sleeves inherent flexibility, evacuation of its interior in this manner will result in the same being drawn around the full arm and hand of the operator, as is represented in FIG. 5 by the arrows 42. If desired, the pre-access chamber defined by the sleeve can then be communicated with the special atmosphere within the enclosure 12 also via the valve 38. In any event, after the sleeve pre-access chamber has been evacuated of the ambient atmosphere, it is a simple matter for the operator to then loosen the wing nut 31 and rotate the latch bar 28 from within the pre-access chamber to permit access of his hand into the chamber without concern for the integrity of the atmosphere within the enclosure. He is then free to perform desired manipulations within the enclosure. In this connection, it may be desired in certain instances for the operator to wear gloves within the enclosure to prevent physical contact between his hand and the object being manipulated. Such gloves, however, can be thin and tightly fitting, such as surgical gloves, rather than the heavy rubber gloves normally associated with glove boxes. Thus, the operators dexterity and feel within the glove box will be essentially unaffected by the gloves.
As mentioned previously, prior art glove boxes typically have not lent themselves to transferring an object between it and a container having a special atmosphere, without requiring the object to pass through the ambient atmosphere. As another salient feature of the instant invention, it includes a simple arrangement enabling transferance of an object between a container and the enclosure without opening either the container or the enclosure to the atmosphere ambient thereto. To this end, the chamber of the invention further includes a pair of essentially identical containers 43 and 44, which are especially adapted to selectively communicate with the enclosure 12. In this connection, as can be seen from FIG. 1, such containers communicate with the enclosure 12 at back walls of the enclosures which obliquely face the access ports to facilitate access of the operator's hand into such containers from within the enclosure.
As illustrated in FIGS. 1 and 7, each ofthe containers 43 and 44 is rectangular in shape and includes an end wall 46 which extends beyond the side walls thereof for a purpose which will be described. An access opening 47 into the container is provided in the end wall 46 and is closed when the container is not in communication with the enclosure by a cover 48. Such cover 48 is illustrated in FIG. 1 within the interior of the enclosure 12 removed from the container access opening 47.
The container access opening 47 of each of the containers is designed to communicate with a corresponding access opening 49 in a back wall panel of the enclosure 12.
As is best illustrated in FIG. 7, a slide cover plate 51 is provided on the exterior side of the enclosure wall for normally closing each enclosure access opening 49. Slide guide means are provided on the enclosure for defining a path for the slide cover traversing the enclosure access opening between a closed position covering the opening as illustrated. and an open position exposing such opening. Such slide guide means is in the form of a pair of parallel guide rails 52 and 53 respectively facing one another from opposite sides of the enclosure access opening 49. Such guide rails define with the wall of the enclosure to which they are secured parallel channels which receive opposite side edges of the slide cover plate 51 as shown. Suitable clamps. such as provided by wing nut and bolt combinations 54, can be provided on each of the guide rails for clamping the cover plate tightly against the enclosure back wall to assure a gas-tight seal around the opening 49.
The end wall 46 of each of the containers defines slide guide means which are complimentary to the slide guide rails 52 and 53 to enable such container wall to traverse the enclosure access opening 49 to replace the slide cover thereover. More particularly, the container end wall 46 has an outer periphery substantially the same as the outer periphery of the cover plate 48 and, in this connection, opposite and parallel side edges 56 and 57 thereof engage within the channels defined by the guide rails 52 and 53. It will be appreciated that with this arrangement, as the slide cover plate 51 is moved, for example, downward from over the opening 49, the container can be moved downward to replace such slide cover. The downward movement of the container can be performed simultaneously with the downward movement of the slide plate so that there is essentially no time at which the access opening 47 is exposed to the atmosphere ambient to the chamber.
To facilitate sliding supplantation of the slide cover plate by the container, the face of the container wall 46 which slides against the enclosure wall is provided with substantially the same geometry as the face of the slide cover plate 51 which also slides against such enclosure wall. In this connection, as can be seen from FIG. 1, the container wall is provided with a recess at the container access opening within which the container cover 48 fits to provide the container cover with a smooth planar surface when the cover is on the container. Means are also provided for both maintaining each container in position over its associated enclosure access opening and holding the cover plate 51 in its open position. More particularly, a stop bar 80 extends transversely between the guide rails 52 and 53. A central slot 82 in the stop bar is engaged by a limit pin 61 projecting from the cover plate adjacent its top edge, when the cover plate is in its lowered position. When the container is properly positioned over the enclosure access opening, the container bottom wall also engages the stop bar in order to prevent further downward movement of the container.
It will be recognized that when the container is so positioned over the enclosure access opening 49, access is provided between such enclosure access opening 49 and the container access opening 47. Moreover, container opening 47 is smaller than enclosure opening 49 so that the cover 48 for the container is removable through the enclosure opening into the enclosure. The integrity of the atmosphere within the interior of the container can be maintained until such time as the container is in position to provide access between it and the enclosure. Thus, in those instances in which the container is maintaining an object or specimen in a special atmosphere prior to the time such container is communicated with the enclosure, the object or specimen need never be passed through the ambient atmosphere when being transferred from the container and the enclosure. Of course, when it is desired to remove the container from the enclosure the container cover is replaced on its opening and then as such container is moved upward for disengagement from the enclosure, the enclosure opening door is moved upward to close the enclosure opening. Moreover, the container is provided with a suitable nipple 59 which can be communicated through line 58 with one of the valves of the manifold 17. Such communication allows the container to be evacuated of any ambient or other undesired atmosphere therein prior to the time such container is communicated with the enclosure 12.
In certain situtations, it is desirable to be able to transfer objects or specimens into the interior of the enclosure from the ambient atmosphere. The environmental chamber of the invention includes an improved pass-through or antechamber for introducing objects into enclosure 12 without opening the latter to the ambient atmosphere. To this end, an antechamber 62 is provided exteriorly of the main enclosure 12 and communicating therewith through a selectively closable post 63 adapted for passage of an object it is desired to introduce into the enclosure. As is illustrated in FIG. 1, port 63 is closed via a door 64 which is hinged adjacent its bottom for swinging operation. Suitable clamps, such as those schematically illustrated at 65, are provided for sealing the door closed. Another door 66 is also provided, closing an opening providing access to the interior of the antechamber from its exterior and, thus, also from the exterior of the main enclosure 12. Suitable clamps 65 operable from the exterior of the chamber are also provided for sealing door 66 closed.
Means are also provided for evacuating antechamber 62 when the doors 64 and 66 are closed. In this connection, a nipple 67 in the top wall of the antechamber is provided communicating through a gas line 68 with a valve 69 of manifold 17.
To the extent described to this point, the antechamber 62 is of a generally conventional nature. In operation, an object to be introduced into the main enclosure 12 is first introduced into the antechamber through the door 66 at a time when the door 63 is closed so that the main chamber is not communicated through the antechamber with the ambient atmosphere. Then with both doors 63 and 66 closed, the ambient atmosphere within the antechamber is evacuated. Such evacuation is achieved by reducing the pressure in the antechamber via the valve 69 and the vacuum source and then, if desired, introducing into such antechamber the special atmosphere which is within the container 12. Once the atmosphere within the antechamber is compatible with that within the enclosure 12, the door 64 can be opened from the interior of such antechamber 12 to enable the object to be passed from the antechamber into the main enclosure.
As mentioned previously, the operation of evacuating an antechamber of the ambient atmosphere to the extent necessary is often a time-consuming operation. The antechamber 62 of the invention, however, includes means for substantially reducing the time involved in such operation. More particularly, as can best be seen from the schematic illustrations in FIGS. 8 and 9, a pair of inflatable bags 71 and 72 are provided within the interior of the antechamber with their stems 73 and 74, respectively, communicating with the ambient atmosphere through apertures 76 and 77 in the side walls of the antechamber. If there is a generally tight fit between each of the stems 73 and 74 and its associated aperture through the side wall of the antechamber, the initial leakage into the antechamber when a vacuum source is communicated with the chamber will be sufficiently low. It will be appreciated, though, that in some instances even low leakage cannot be tolerated and it may be necessary to seal the stem to the side wall to prevent leakage.
Each of the bags provides, in effect, a wall portion of the antechamber which responds to the reduction of gas pressure therein by moving inwardly of such antechamber to reduce its volume. More particularly, because the stems 73 and 74 extend to the exterior of the antechamber, the interior of each of the bags is communicated with the ambient atmosphere. Thus, when the valve 69 is actuated to communicate the vacuum source with the interior of the antechamber and its pressure is correspondingly reduced relative to the ambient atmosphere pressure, each of the inflatable bags 71 and 72 will expand due to such difference in pressure. Such expansion will result in a consequent reduction in the volume of the antechamberv This will increase the speed at which the antechamber is evacuated since, as is known, as the density of a gas which is being evacuated from a volume decreases, the amount of time that any given vacuum source must be communicated with the volume to cause further reduction correspondingly increases. The reduction of the volume of the antechamber by inflation of the bags 71 and 72 tends to maintain the density of the gas being removed from such chamber generally equal to the ambient pressure. Thus, the vacuum source will see a high density of gas throughout its actuated period, with the result that such period will be substantially reduced in time. It will be recongized that after the required amount of ambient atmosphere is removed from the antechamber, the valve 69 can be manipulated to introduce into such antechamber a desired special atmosphere prior to the opening of door 64 to provide communication with the enclosure 12.
From the above, it will be seen that the environmental chamber of the invention has several features which represent improvements over the prior art. And although the chamber has been described in connection with a preferred embodiment thereof, it will be appreciated that various changes and modifications can be made without departing from its spirit. It is therefore intended that the coverage afforded applicant be limited only by the claims and their equivalent language.
1. A chamber for maintaining an object in an isolated environment comprising an enclosure for separating said object from an atmosphere ambient to said chamber; and at least one access port enabling admission of the hand of an operator into said enclosure for manipulation of an object therein, said access port including a door sealing an aperture in the wall of said enclosure through which said hand is extendable into the interior of said enclosure, and a sleeve sealed to said enclosure in communication with said aperture, a free end portion of said sleeve extending to the exterior of said enclosure and providing a pre-access chamber for separating the hand of the operator from the ambient atmosphere prior to the opening of said door for access of said hand into said enclosure.
2. The chamber of claim 1 wherein said door includes locking means manipulatable from within said sleeve exteriorly of said enclosure, whereby said hand of said operator can open said door from said preaccess chamber for access into said enclosure.
3. The chamber of claim 1 further including means for evacuating said pre-access chamber of said ambient pressure prior to the opening of said door for access of said hand into said enclosure.
4. The chamber of claim 1 wherein said free end portion of said sleeve is adapted to sealingly engage the arm of an operator inserted therein toward said aperture.
5. The chamber of claim 4 further including means for evacuating said pre-access chamber prior to the opening of said door and wherein said door includes locking means manipulatable from within said sleeve exteriorly of said enclosure for opening the same inwardly of said enclosure, whereby said hand of said operator can open said door from said pre-access chamber for access into said enclosure.
6. The chamber of claim 4 further including an antechamber for introducing said object into said enclosure without opening the same to the ambient atmosphere comprising a second enclosure exterior of said first enclosure and communicating therewith through a selectively closable port adapted for passage of said object, a door on said second enclosure to provide access thereinto for said object from the exterior of both said first and second enclosures, means for reducing the pressure of gas within said second enclosure when said port and said door are closed, and a wall portion on said second enclosure which responds to reduction of gas pressure within said second enclosure by moving inwardly of said second enclosure to reduce the volume thereof.
7. A chamber for maintaining an object in an isolated environment comprising an enclosure for separating said object from an ambient atmosphere; a container for said object when it is outside of said enclosure having a cover in a wall thereof sealing an access opening therein; and means for transferring said object between said container and said enclosure without opening either said container or said enclosure to the atmosphere ambient thereto, said means including an access opening through the wall of said enclosure, a slide cover on the exterior side of said enclosure for closing said enclosure access opening, slide guide means on said enclosure defining a path for said slide cover transversing said enclosure access opening between a closed position covering said opening and an open position exposing said opening, and slide guide means on the wall of said container through which the container access opening extends complementary to said slide guide means on said enclosure for guiding said container wall traversing said enclosure access opening to replace said slide cover thereover upon said slide cover moving to said open position.
8. The chamber of claim 7 wherein said cover for said container access opening is fittable through said enclosure access opening when access is provided between said enclosure and container access openings to enable removal from the interior of said enclosure of said cover from said container opening to thereby provide communication between said enclosure and the interior of said container.
9. The chamber of claim 7 wherein said slide guide means on said enclosure is a pair of parallel guide rails respectively facing one another from opposite sides of said enclosure access opening, and said complementary slide guide means on said container wall are opposite and parallel side edges of said wall adapted to engage said guide rails.
10. The chamber of claim 9 wherein said container wall is provided with a recess at said container access opening within which said cover fits to provide said container wall with a smooth planar surface when said cover closes said opening, whereby sliding movement of said container wall along said path is facilitated.
11. The chamber of claim 7 further including an antechamber for introducing said object into said enclosure without opening the same to the ambient atmosphere comprising a second enclosure exterior of said first enclosure and communicating therewith through a selectively closable port adapted for passage of said object, a door on said second enclosure to provide access thereinto for said object from the exterior of both said first and second enclosures, means for reducing the pressure of gas within said second enclosure when said port and said door are closed, and a wall portion on said second enclosure which responds to reduction of gas pressure within said second enclosure by moving inwardly of said second enclosure to reduce the volume thereof.
12. The chamber of claim 7 wherein said enclosure further includes at least one access port enabling admission of the hand of an operator into said enclosure for manipulation of an object therein, said access port including a door sealing an aperture in the wall of said enclosure through which said hand is extendable into the interior of said enclosure and a sleeve sealed to said enclosure in communication with said aperture, a free end portion of said sleeve extending to the exterior of said enclosure and providing a pre-access chamber for separating the hand of the operator from the ambient atmosphere prior to the opening of said door for access of said hand into said enclosure.
13. An antechamber for introducing an object into an enclosure defining an isolated environment without opening said enclosure to the ambient atmosphere comprising a second enclosure exterior of said first enclosure and communicating therewith through a selectively closable port adapted for passage of said object, a door on said second enclosure to provide access thereinto for said object from the'exterior of both said first and said second enclosures, means for reducing the pressure within said second enclosure when said port and said door are closed, and a wall portion of said second enclosure which responds to reduction of gas pressure within said second enclosure by moving inwardly of said enclosure to reduce the volume thereof.
14. The antechamber of claim 13 wherein the side of said wall portion on the exterior of said second enclosure is communicated with the ambient atmosphere, whereby it is the difference in pressure provided by said ambient atmosphere and the gas pressure within said second enclosure which causes said movement of said wall portion inwardly of said second enclosure to reduce the volume thereof.
15. The antechamber of claim 1 wherein said wall portion is provided by a sheet of flexible material which is moved inwardly by said differential pressure to provide said reduction in the volume of said second enclosure.
16. The antechamber of claim 15 wherein said wall portion of a flexible material is the wall of an inflatable bag, the interior of which is communicated with the ambient atmosphere for expansion of its volume into said second enclosure and a consequent reduction of the volume of said second enclosure upon said reduction of gas pressure within said second enclosure.
l l l
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2244082 *||14 Jun 1937||3 Jun 1941||Reyniers James A||Apparatus for and method of maintaining and working with biological specimens in a germfree controlled environment|
|US2720387 *||12 Aug 1953||11 Oct 1955||Gordon Armstrong Company Inc||Nebulizing device for infant incubators|
|US2786740 *||9 Jul 1954||26 Mar 1957||Air Reduction||Special atmosphere device|
|US3187744 *||31 Jan 1961||8 Jun 1965||Air Reduction||Incubator|
|US3335713 *||5 Nov 1963||15 Aug 1967||Air Shields||Infant incubator|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4026286 *||25 May 1976||31 May 1977||National Research Development Corporation||Isolators|
|US4059903 *||31 Mar 1976||29 Nov 1977||Futurecraft Corporation||Controlled environment work enclosure|
|US4089571 *||8 Apr 1976||16 May 1978||Landy Jerome J||Glove port and insert|
|US4111753 *||7 Jun 1976||5 Sep 1978||National Appliance Company||Controlled atmosphere apparatus and method of transferring specimens to same|
|US4262091 *||27 Apr 1979||14 Apr 1981||Anaerobe Systems||Preparation of contaminant free containers of culture medium|
|US4505190 *||19 Apr 1982||19 Mar 1985||Nuclear & Environmental Protection, Inc.||Portable maintenance exhaust hood|
|US4566293 *||3 Dec 1984||28 Jan 1986||The B. F. Goodrich Company||Method of sample preparation and apparatus therefor|
|US4612916 *||25 Jul 1984||23 Sep 1986||Calspan Corporation||Method for treating casualties in a contaminated area|
|US4812700 *||1 Dec 1986||14 Mar 1989||Gpac, Inc.||Portable containment device for treatment of hazardous materials|
|US4922807 *||29 Sep 1989||8 May 1990||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Ballast system for maintaining constant pressure in a glove box|
|US4950222 *||28 Sep 1988||21 Aug 1990||Lone Star Medical Products, Inc.||Isolator for use in surgery or as a clean room and method of using the same|
|US4960143 *||12 Feb 1988||2 Oct 1990||Aerospace America, Inc.||Containment apparatus|
|US4995420 *||10 Aug 1990||26 Feb 1991||The United States Of America As Represented By The United States Department Of Energy||Glove box valve system|
|US5056875 *||20 Mar 1989||15 Oct 1991||Motorola, Inc.||Container for use within a clean environment|
|US5127718 *||30 Oct 1990||7 Jul 1992||Shelley R. Paine||Museum display case having improved airtight seal|
|US5275479 *||30 Apr 1993||4 Jan 1994||Commissariat A L'energie Atomique||System of doors between two mobile containers, particularly two ultraclean containers|
|US5380077 *||8 Jul 1992||10 Jan 1995||Kaltenbach & Voigt Gmbh & Co.||Machining device for machining precision, in particular dental, workpieces in a machining chamber surrounded by a housing|
|US5562593 *||2 Jun 1995||8 Oct 1996||The United States Of America As Represented By The United States Department Of Energy||Split ring containment attachment device|
|US5863505 *||27 May 1997||26 Jan 1999||Kabushiki Kaisha Kobe Seiko Sho||Underground-environment simulator|
|US5918290 *||29 Apr 1998||29 Jun 1999||The Porter Company/Mechanical Contractors||Multi-product sampling apparatus and method|
|US5950642 *||12 Nov 1997||14 Sep 1999||Porter Company/Mechanical Contractors||Clean connection and sampling apparatus and method|
|US6060020 *||9 Apr 1998||9 May 2000||S.P.M. Recovery Technologies Ltd||Method and apparatus for treating objects with ozone|
|US6383162||12 Nov 1999||7 May 2002||Paul H. Sugarbaker||Apparatus and method for abdomino-pelvic chemotherapy perfusion and lavage|
|US6428122 *||6 Feb 2001||6 Aug 2002||The United States Of America As Represented By The Secretary Of The Army||Portable glovebox and filtration system|
|US6620379||21 Dec 1999||16 Sep 2003||S.P.M. Recovery Ltd.||Apparatus and method of treatment of wounds, burns and immune system disorders|
|US6846287||29 Apr 2002||25 Jan 2005||Atropos Limited||Surgical device for retracting and/or sealing an incision|
|US6974197 *||5 Apr 2004||13 Dec 2005||The United States Of America As Represented By The Secretary Of The Army||Portable glovebox and filtration system|
|US7081089||1 Jul 2005||25 Jul 2006||Atropos Limited||Surgical device for retracting and/or sealing an incision|
|US7300399||24 Nov 2004||27 Nov 2007||Atropos Limited||Surgical device for retracting and/or sealing an incision|
|US7325890 *||30 Sep 2004||5 Feb 2008||Kikusui Seisakusho Ltd.||Glove fitting device|
|US7445597||27 Feb 2003||4 Nov 2008||Atropos Limited||Retractor|
|US7527603 *||29 Jan 2007||5 May 2009||Sun-Tae An||Ozone treatment apparatus using ozone gas|
|US7537564||23 Mar 2005||26 May 2009||Atropos Limited||Wound retractor device|
|US7540839||6 Aug 2003||2 Jun 2009||Atropos Limited||Wound retractor|
|US7559893||6 Oct 2003||14 Jul 2009||Atropos Limited||Wound retractor device|
|US7612312 *||11 Feb 2005||3 Nov 2009||Honeywell International Inc.||Mobile hand-held laser welding support system|
|US7765868 *||20 Sep 2004||3 Aug 2010||Evotec Technologies Gmbh||Climate chamber for microscopes|
|US7867164||22 Sep 2003||11 Jan 2011||Atropos Limited||Wound retractor system|
|US7975713 *||26 Aug 2008||12 Jul 2011||Centerpoint Energy Alternative Fuels, Inc.||Continuous gas service restoration and meter change-out system|
|US7998068||11 Oct 2005||16 Aug 2011||Atropos Limited||Instrument access device|
|US8016755||3 Dec 2010||13 Sep 2011||Applied Medical Resources Corporation||Surgical access apparatus and method|
|US8021296||14 Jul 2006||20 Sep 2011||Atropos Limited||Wound retractor|
|US8070676||3 Dec 2010||6 Dec 2011||Applied Medical Resources Corporation||Surgical access apparatus and method|
|US8105234||27 Jan 2009||31 Jan 2012||Applied Medical Resources Corporation||Surgical access apparatus and method|
|US8109873||12 May 2008||7 Feb 2012||Applied Medical Resources Corporation||Surgical retractor with gel pad|
|US8157835||1 Jun 2010||17 Apr 2012||Applied Medical Resouces Corporation||Access sealing apparatus and method|
|US8187177||29 Nov 2006||29 May 2012||Applied Medical Resources Corporation||Surgical instrument access device|
|US8187178||5 Jun 2008||29 May 2012||Atropos Limited||Instrument access device|
|US8226552||12 May 2008||24 Jul 2012||Applied Medical Resources Corporation||Surgical retractor|
|US8235054||22 Feb 2011||7 Aug 2012||Applied Medical Resources Corporation||Wound retractor|
|US8262568||13 Oct 2009||11 Sep 2012||Applied Medical Resources Corporation||Single port access system|
|US8267858||18 Jan 2011||18 Sep 2012||Applied Medical Resources Corporation||Wound retractor with gel cap|
|US8308639||17 Mar 2011||13 Nov 2012||Applied Medical Resources Corporation||Split hoop wound retractor with gel pad|
|US8313431||15 Oct 2010||20 Nov 2012||Applied Medical Resources Corporation||Split hoop wound retractor|
|US8317691||20 Apr 2009||27 Nov 2012||Atropos Limited||Wound retractor device|
|US8328042 *||14 Jan 2009||11 Dec 2012||J.M. Canty, Inc.||Vessel port configured for use with a glove bag|
|US8343047||22 Jan 2009||1 Jan 2013||Applied Medical Resources Corporation||Surgical instrument access device|
|US8357086||3 May 2012||22 Jan 2013||Applied Medical Resources Corporation||Surgical instrument access device|
|US8375955||5 Feb 2010||19 Feb 2013||Atropos Limited||Surgical procedure|
|US8388526||23 Apr 2008||5 Mar 2013||Applied Medical Resources Corporation||Wound retraction apparatus and method|
|US8414487||8 Feb 2011||9 Apr 2013||Applied Medical Resources Corporation||Circular surgical retractor|
|US8480575||28 Aug 2012||9 Jul 2013||Applied Medical Resources Corporation||Single port access system|
|US8496581||15 Mar 2012||30 Jul 2013||Applied Medical Resources Corporation||Surgical access apparatus and method|
|US8647265||14 Jan 2011||11 Feb 2014||Applied Medical Resources Corporation||Hand access laparoscopic device|
|US8657740||27 Jan 2010||25 Feb 2014||Atropos Limited||Instrument access device|
|US8657741||15 Aug 2011||25 Feb 2014||Atropos Limited||Wound retractor|
|US8672839||13 Sep 2011||18 Mar 2014||Applied Medical Resource Corporation||Surgical access apparatus and method|
|US8703034||23 Aug 2011||22 Apr 2014||Applied Medical Resources Corporation||Method of making a tack-free gel|
|US8721537||27 Jun 2013||13 May 2014||Applied Medical Resources Corporation||Single port access system|
|US8734336||23 Apr 2009||27 May 2014||Atropos Limited||Wound retractor device|
|US8740785||19 Oct 2010||3 Jun 2014||Atropos Limited||Wound retractor system|
|US8752553||20 Jun 2003||17 Jun 2014||Atropos Limited||Apparatus for use in surgery and a valve|
|US8758236||9 May 2012||24 Jun 2014||Applied Medical Resources Corporation||Wound retractor|
|US8870904||12 Mar 2012||28 Oct 2014||Applied Medical Resources Corporation||Access sealing apparatus and method|
|US8888693||1 Jul 2011||18 Nov 2014||Atropos Limited||Instrument access device|
|US8894571||1 Apr 2014||25 Nov 2014||Applied Medical Resources Corporation||Single port access system|
|US8911366||11 Jan 2012||16 Dec 2014||Applied Medical Resources Corporation||Surgical access apparatus and method|
|US8932214||11 May 2011||13 Jan 2015||Applied Medical Resources Corporation||Surgical access system|
|US8961410||6 Jan 2012||24 Feb 2015||Applied Medical Resources Corporation||Surgical retractor with gel pad|
|US8973583||26 Jun 2012||10 Mar 2015||Applied Medical Resources Corporation||Wound retractor|
|US8986202||8 Aug 2011||24 Mar 2015||Atropos Limited||Retractor|
|US9017254||7 Jan 2014||28 Apr 2015||Applied Medical Resources Corporation||Hand access laparoscopic device|
|US9055799 *||4 Oct 2007||16 Jun 2015||Elizabeth E. Cohn||Isolation box for protecting reading material|
|US9095300||18 Oct 2012||4 Aug 2015||Atropos Limited||Wound retractor device|
|US9101354||29 Aug 2012||11 Aug 2015||Applied Medical Resources Corporation||Wound retractor with gel cap|
|US9180597 *||17 Jun 2008||10 Nov 2015||The United States Of America As Represented By The Secretary Of The Army||Mobile analytical screening, verification, and containment system|
|US9192366||23 May 2014||24 Nov 2015||Applied Medical Resources Corporation||Wound retractor|
|US9194175||19 Jul 2013||24 Nov 2015||Savannah River Nuclear Solutions, Llc||Interchangeable breech lock for glove boxes|
|US9241697||19 Jun 2014||26 Jan 2016||Applied Medical Resources Corporation||Wound retractor|
|US9271753||7 Aug 2003||1 Mar 2016||Atropos Limited||Surgical device|
|US9277908||27 Feb 2015||8 Mar 2016||Atropos Limited||Retractor|
|US9279099 *||18 Jan 2013||8 Mar 2016||Tokyo Women's Medical University||Processing system for cell cultures and module connecting method of processing system for cell cultures|
|US9289115||18 Apr 2013||22 Mar 2016||Applied Medical Resources Corporation||Natural orifice surgery system|
|US9289200||30 Sep 2011||22 Mar 2016||Applied Medical Resources Corporation||Natural orifice surgery system|
|US9295459||18 Dec 2014||29 Mar 2016||Applied Medical Resources Corporation||Surgical access system|
|US9307975||19 Jun 2014||12 Apr 2016||Applied Medical Resources Corporation||Wound retractor|
|US9307976||27 Jan 2014||12 Apr 2016||Atropos Limited||Wound retractor|
|US9351759||12 Apr 2012||31 May 2016||Atropos Limited||Instrument access device|
|US9408597||7 Oct 2013||9 Aug 2016||Atropos Limited||Instrument access device|
|US9474519||8 Apr 2015||25 Oct 2016||Applied Medical Resources Corporation||Hand access laparoscopic device|
|US9524805||19 Feb 2014||20 Dec 2016||Commissariat A L'energie Atomique Et Aux Energies Alternatives||Device for protecting against ionising radiation and containment enclosure provided with such a device|
|US9561024||4 Feb 2015||7 Feb 2017||Applied Medical Resources Corporation||Wound retractor|
|US9642608||16 Jul 2015||9 May 2017||Applied Medical Resources Corporation||Gels having permanent tack free coatings and method of manufacture|
|US9649102||8 Jul 2015||16 May 2017||Applied Medical Resources Corporation||Wound retractor with split hoops|
|US9669153||12 Mar 2014||6 Jun 2017||Applied Medical Resources Corporation||Method of manufacturing a tack-free gel for a surgical device|
|US9700296||29 Jun 2015||11 Jul 2017||Atropos Limited||Wound retractor device|
|US9737335||12 Jan 2016||22 Aug 2017||Atropos Limited||Device|
|US9757110||28 Aug 2014||12 Sep 2017||Atropos Limited||Instrument access device|
|US20030078478 *||29 Apr 2002||24 Apr 2003||Atropos Limited||Surgical device for retracting and/or sealing an incision|
|US20030193272 *||9 Nov 2001||16 Oct 2003||Bryan John I.||Mail handling safety system|
|US20040049100 *||27 Feb 2003||11 Mar 2004||Atropos Limited||Retractor|
|US20040060926 *||30 Aug 2002||1 Apr 2004||Michael Weiss||Electric heating device comprising a coated heat conductor|
|US20040215063 *||20 Jun 2003||28 Oct 2004||Atropos Ltd.||Apparatus for use in surgery and a valve|
|US20040215362 *||6 Apr 2004||28 Oct 2004||Mamoru Kokubo||Aseptic system and method for using the same|
|US20050090716 *||24 Nov 2004||28 Apr 2005||Atropos Limited||Surgical device for retracting and/or sealing an incision|
|US20050090717 *||6 Oct 2003||28 Apr 2005||Frank Bonadio||Wound retractor device|
|US20050155611 *||5 Nov 2004||21 Jul 2005||Trevor Vaugh||Surgical sealing device|
|US20050197537 *||23 Mar 2005||8 Sep 2005||Frank Bonadio||Wound retractor device|
|US20050203346 *||23 Mar 2005||15 Sep 2005||Frank Bonadio||Wound retractor device|
|US20050240082 *||1 Jul 2005||27 Oct 2005||Atropos Limited||Surgical device for retracting and/or sealing an incision|
|US20050269916 *||30 Sep 2004||8 Dec 2005||Kikusui Seisakusho Ltd.||Glove fitting device|
|US20060247498 *||11 Oct 2005||2 Nov 2006||Frank Bonadio||Instrument access device|
|US20070004968 *||1 Dec 2005||4 Jan 2007||Frank Bonadio||Seal for a cannula|
|US20070118175 *||7 Aug 2003||24 May 2007||John Butler||Device|
|US20070234829 *||20 Sep 2004||11 Oct 2007||Matthias Pirsch||Climate Chamber for Microscopes|
|US20080045874 *||29 Jan 2007||21 Feb 2008||Sun-Tae An||Ozone treatment apparatus using ozone gas|
|US20080203103 *||4 Oct 2007||28 Aug 2008||Cohn Elizabeth E||Portable reverse isolation box (PRIB)|
|US20080284289 *||14 May 2008||20 Nov 2008||Lift-Off Technologies Corporation||Space-suit matable enclosure providing workspace for astronauts|
|US20090139967 *||11 Feb 2005||4 Jun 2009||Honeywell International, Inc.||Mobile hand-held laser welding support system|
|US20090173392 *||26 Aug 2008||9 Jul 2009||Winston Charles Meyer||Continuous Gas Service Restoration and Meter Change-Out System|
|US20100044372 *||27 Oct 2008||25 Feb 2010||Her Majesty The Queen in Right of Canada as Represented by the Minister of Public Safety||Portable and collapsible chem./bio. isolators|
|US20100176132 *||14 Jan 2009||15 Jul 2010||J.M. Canty, Inc.||Vessel port configured for use with a glove bag|
|US20110142574 *||8 May 2009||16 Jun 2011||Lugaia Sts Sterile Transfer Solutions Ag||Method of transferring an object into a clean room|
|US20120311932 *||11 Jun 2012||13 Dec 2012||Los Alamos National Security, Llc||Glovebox safety apparatus and system|
|US20140232248 *||12 Feb 2014||21 Aug 2014||Don Whitley Scientific Limited||Controlled atmosphere workstation|
|CN101813682A *||23 Mar 2010||25 Aug 2010||中国人民解放军第三军医大学第一附属医院||Constant temperature and humidity operation console|
|CN101813682B||23 Mar 2010||23 May 2012||中国人民解放军第三军医大学第一附属医院||Constant temperature and humidity operation console|
|CN103370409A *||5 Jan 2012||23 Oct 2013||学校法人东京女子医科大学||Cell culture treatment system, and method for connection of modules for cell culture treatment system|
|CN103370409B *||5 Jan 2012||10 May 2017||学校法人东京女子医科大学||细胞培养处理系统以及细胞培养处理系统的模块连接方法|
|CN105027226A *||19 Feb 2014||4 Nov 2015||原子能及能源替代委员会||Device for protecting against ionising radiation and containment enclosure provided with such a device|
|CN105027226B *||19 Feb 2014||22 Aug 2017||原子能及能源替代委员会||防电离辐射的保护装置以及装有这种保护装置的封闭壳|
|EP2447351A4 *||22 Jun 2010||9 Sep 2015||Cellseed Inc||Personal box for collection preparation, collection preparation system, and collection preparation method|
|EP2518137A1 *||26 Apr 2012||31 Oct 2012||Panasonic Healthcare Co., Ltd.||Isolator and method for moving culture|
|EP2604679A1 *||5 Jan 2012||19 Jun 2013||Tokyo Women's Medical University||Cell culture treatment system, and method for connection of modules for cell culture treatment system|
|EP2604679A4 *||5 Jan 2012||25 Dec 2013||Univ Tokyo Womens Medical||Cell culture treatment system, and method for connection of modules for cell culture treatment system|
|EP2767338A3 *||6 Feb 2014||6 Jan 2016||Don Whitley Scientific Limited||Controlled atmosphere workstation|
|WO1986000870A1 *||29 Jul 1985||13 Feb 1986||Asyst Technologies||Sealed standard interface apparatus|
|WO1986006272A1 *||16 Apr 1986||6 Nov 1986||Lone Star Medical Products, Inc.||Isolator for use in surgery|
|WO2005074854A1 *||3 Feb 2004||18 Aug 2005||Sanjay Prabhakar Gadekar||A table top mobile operation theatre|
|WO2009153676A1 *||8 May 2009||23 Dec 2009||Lugaia Sts Sterile Transfer Solutions Ag||Method for conveying an object into a clean room|
|U.S. Classification||312/1, 600/21, 976/DIG.363, 976/DIG.362|
|International Classification||G21F7/053, B25J21/02, B01L1/00, B01L1/02, B25J21/00, G21F7/00, G21F7/047|
|Cooperative Classification||C12M41/14, B25J21/02, G21F7/047, G21F7/053, B01L1/02|
|European Classification||C12M41/14, B25J21/02, G21F7/047, G21F7/053, B01L1/02|
|25 May 1982||AS02||Assignment of assignor's interest|
Owner name: COX, MARION E. 8005 RAINBOW DRIVE, CUPERTINO, CA 9
Owner name: COX, MARY E 8005 RAINB
Owner name: PACIFIC LABORATORY EQUIPMENT, INC. A CA CORP.
Effective date: 19820427
|25 May 1982||AS||Assignment|
Owner name: COX, MARION E. 8005 RAINBOW DRIVE, CUPERTINO, CA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:PACIFIC LABORATORY EQUIPMENT, INC. A CA CORP.;REEL/FRAME:003992/0206
Effective date: 19820427
Owner name: COX, MARY E 8005 RAINBOW DRIVE, CUPERTINO, CA 95
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:PACIFIC LABORATORY EQUIPMENT, INC. A CA CORP.;REEL/FRAME:003992/0206
Owner name: COX, MARION E.,CALIFORNIA
Owner name: COX, MARY E,CALIFORNIA