US3894538A - Device for supplying medicines - Google Patents

Device for supplying medicines Download PDF

Info

Publication number
US3894538A
US3894538A US386058A US38605873A US3894538A US 3894538 A US3894538 A US 3894538A US 386058 A US386058 A US 386058A US 38605873 A US38605873 A US 38605873A US 3894538 A US3894538 A US 3894538A
Authority
US
United States
Prior art keywords
container
electrodes
accordance
current
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US386058A
Inventor
Gerhard Richter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Original Assignee
Siemens AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19722239432 external-priority patent/DE2239432C3/en
Application filed by Siemens AG filed Critical Siemens AG
Application granted granted Critical
Publication of US3894538A publication Critical patent/US3894538A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M2005/14204Pressure infusion, e.g. using pumps with gas-producing electrochemical cell

Definitions

  • ABSTRACT A device for supplying medicines or the like to the body of man or beast has a container for preserving a medicine as well as means for changing the volume of the container.
  • the container has an opening through which the medicine is ejected when the volume of the container is diminished.
  • the invention is particularly characterized by the provision of another container operatively joined to the first-mentioned container and having a variable volume for varying the volume of the first-mentioned container.
  • the change in volume of the other container is produced by gas or liquid particles diffused or entering through electrical fields or by electrolytical gas development within the container.
  • An object of the present invention is the provision of a device which is operable without the assistance of a doctor or the use of the patient for providing automatically for long time periods a comparatively precise dosage of a medicine.
  • the container of the described type another container of variable volume serving as means for varying the volume of the medicine-carrying container.
  • the change in volume of the second container is produced by gas or liquid particles diffused or entering through electrical fields or by electrolytical gas development within the container.
  • the regulation of the delivery of medicine out of the medicine-carrying container by a change in volume of another container operatively connected with the medicine carrying container makes it possible to provide with the simplest technical means an extremely precise dosage of the medicine being delivered for long time periods.
  • volume changes of a container as such can be continuously precisely produced in a simple manner and can be controlled.
  • the changes in volume actuated by gas or liquid particles diffused or entering through electrical fields or by electrolytical gas development is particularly advantageous since such flows have an extremely precise uniformity over long time periods, so that changes in volume of the container regulating the delivery of the medicine out of the medicine carrying container also have a high extent of continuity over long time periods. Furthermore.
  • the dosage of the medicine can be made extremely fine, since the gas or liquid diffused or field currents or electrolytically produced gas currents causing the passage of medicine out of the medicine-carrying container can be kept extremely small by suitable shaping or measuring of the gas or liquid diffusion passage or of the electrolytic gas developer in the container.
  • the medicine-carrying container can be made totally or partly of elastic material and means can be provided for transforming volume changes of the other container into a compressing force exerted upon the elastic material.
  • the other container can press with at least a part of its walls directly upon the elastic material of the medicinecarrying container.
  • the medicinecarrying container is preferably placed within the main container or so arranged that at least the elastic part of the medicine-carrying container constitutes at the same time a part of the wall of the main container.
  • the main container has a rigid casing the interior of which is divided by a separating wall into two chambers one of which has an outflow opening and is used to receive the medicine. while the second one has a diaphragm window through which gas or liquid particles can be diffused or entered by electrical field action or which can contain a gas producer for electrolytic gas separation. whereby the separating wall can be pushed into the first chamber due to an increase of gas or liquid in the second chamber.
  • the diffusion or entry of gas or liquid particles into the second chamber preferably takes place either in the usual osmotic manner or in the electro-osmotic manner.
  • the electro-osmotic effect as well as the electrolytic gas production in a further container permit a-medicine dosage which can be operated or regulated from the outside to a certain extent. by setting currents of different strengths between electrodes required for producing the electro-osmotic effect or for electrolytic gas separation.
  • the operation or regulation of the. dosage can take place preferably by measure value-signals which are obtained from or in the body of the patient and constitute a measure for the size of the body to be affected by the medicine.
  • Thedevice of the present invention is paticularly suitable for implantation into the body of a patient. However, it can be obviously used outside of the body. for example. by being carried upon the surface of the body.
  • FIG. 1 is a section through an implantable device of the present invention operating according to normal osmose.
  • FIG. 2 is a section through an implantable device of the present invention operating according to electroosmose.
  • FIG. 3 is a section through an implantable device of the present invention wherein changes in volume of the container actuating the medicine-carrying container are caused by gases produced electrolytically in the container.
  • the casings are indicated by the numeral 1 in the 3 not transmit liquid and is well adapted. to tissue, for example. epoxide resin. I l
  • the interior of the casing l is divided by a diaphragm 2 into two separate chambers 3- and 4, whereby .the chamber 3 is used for receiving a medicine. for example. insulin for treating diabetes. while chamber 4 serves for creating osmotic pressure as the result of which the diaphragm 2 is slowly pressed into the chamber 3 and thus by this extension presses the medicine located in the'chamber 3 through an outflow opening 5 provided in the container.
  • the diaphragm 2 consists of a liquid-tight material. preferably a -plastic. and is elastic. It is also possible to additionally metallize the diaphragm 2 as well as the interior of the medicine containing chamber 3 to provide greater im'permeability against liquids and to prevent possible chemical reactions of the medicine with the material of the casing or diaphragm, v
  • the liquid medicine driven through the opening S' is transported through a thin tube 6 connected to the opening 5 to a suitable location in the body of the patient. for example. into the blood flow, and is there released.
  • the free end of the tube 6 is preferably provided with a finely porous plug 7 which prevents return diffusion of the body liquid into the medicinecontaining chamber 3 or an uncontrolled outflow of the medicine out of the chamber 3.
  • the plug can consist of porous teflon or a hydrophylic material. such as cellulose. or an ion exchanging material.
  • the width of the pores of the plug material shouldbe less than lOOum. preferably between 1 and 20am.
  • the creation of osmotic pressure in the chamber 4 takes place in a normal osmotic manner.
  • the wall of the chamber 4 is provided with a diaphragm window 8 consisting of a semi-permeable material which can transmit water or steam. and also small loose molecules or ions. but not the substance located within the chamber4 and used to buildup osmotic pressure in the chamber.
  • the window 8 can be either rigid or can be held by porous rigid supports. preventing it from moving outwardly when pressure is increased.
  • the material of the diaphragm can be either a hydrophobic material. for example. porous or also nonporous teflon, polyethylene or silicon. or the diaphragm can consist of a hydrophilic material. for example, cellulose. cellulose derivatives or ion exchangers. lf porous teflon is used as the diaphragm material. then the width of its individual pores must be narrower than the width of the pores of the material of the plug located at the outlet of the medicine transmitting tube 6.
  • the steam pressure in the chamber 4 must be small relatively to steam pressure in the body liquid surrounding the casing 1. Furthermore. changes of steam pressure in the pressure chamber must remain small during the operational period, compared with the steam pressure difference relatively to body liquid.
  • the dosage of the medicine is then determined by the extent of diffusion of water or steam in the chamber 4. The extent of transmission of the semipermeable window 8, its size and with low steam partial pressure for the interior of the chamber 4.
  • the interior of the chamber 4 should be filled with a polyelectrolite or a gel.
  • the osmotic pressure is then produced due to a so-called Donnan weight balance.
  • osmotic pressure in the chamber 4 is produced by an electro-osmotic effect.
  • the wall of the casing of the chamber 4 is provided with a diaphragm window 9 which is electrically charged and transmits ions.
  • the window 9 is fixed between two electrodes 10 and 11 which produce a current through the window.
  • the electrodes must be so polarized that counter ions move inwardly through the window to the solid ions, namely in the direction toward the chamber 4. If, for example, the window has cation exchange properties, then the electrode 10 must be polarized negatively and the electrode 11 must be polarized positively.
  • the electrodes 10' and 11 lie directly upon both sides of the window 9, they must be also made porous and filled with an electrolite, so that the electro-osmotic transportation of water through them'can take place. Furthermore. the-electrode 11 should be screened by a diaphragm 12 transmitting ions and suitable for tissue to avoid its contact with bodily tissue. v
  • the electrodes 10, 11 can be supplied with outside vcurrent, for example. by a battery 13 through a potentiometer 14 which can be connectedby outlet contacts 15 and 16 with the current connecting contacts 17 and 18 of the electrodes 10 and ll. If the electrodes consist of an inert material. such as platinum, then care must be taken that the. feeding current should not exceed the amount of l mA/cm so that no gas development should take place (diffusion limit current).
  • the electrodes '10 and 11 can be advantageously so constructed that they themselves will supply the current.
  • an electrode consisting for example of zinc. cadmium, aluminum or glucose can be used as anode and as cathode can be a silver/silver chloride or an oxygen/carbon electrode.
  • the glucose electrode which, for example, consists of platinum black or Raney-platinumruthenium, must be applied to the side facing the chamber 4 of the hydrophilic window constructed as anion exchanger (electrode 10).
  • the oxygen electrode consists of porous charcoal and is located upon the outer side of the window 9 (electrode 11).
  • the coal electrode- is selective and reacts only with oxygen, the glucose is diffused without hindrance through the coal electrode and the window 9 to the non-selective precious metal electrode and can be reacted there.
  • a resistance 19 is connected, preferably a potentiometer for setting different cell currents, a current will flow between the electrodes.
  • device devide ofthe'present invention 7 having a glucose-oxygen-electrode combination is par- 7 current between the electrodes is also directly depenthickness are to be selected depending upon the Ldesired dosage.
  • Zincor calcium chloride is suggested as-a substance dent froin'theglucose content of the tissue liquid of the patientlfa more or less strong current corresponding to height of the blood glucose mirror is produced in 'a' tim e'un it through the window, and thus more or less 'wateris fdiffu se cl in thesame timeperiod into the chamher 4 and thus due to a more or less quick filling of this space 4 a correspondingly strong or less strong insulin is transmitted through the opening 5 and tube 6' to the blood of the patient.
  • a device of this type carries out already by itself a certain regulating function with respect to an increased insulin delivery at a higher glucose mirror and a correspondingly weaker insulin delivery at a correspondingly lower glucose mirror.
  • the amount of medicine which should be transmitted from the medicine container 3 into the tissue or blood of a patient corresponds to the amount ofsolution (water and ions) which is transmitted through the diaphragm window 8 or 9 into the chamber 4.
  • this amount of solution and thus the delivered amount of medicine are determined directly by the strength of electro-osmotically actuating current. For example. per Faraday (96500 As) are transported by a cation exchange diaphragm at a current strength of l mA/cm 50 mol of solution (corresponding to 90 gr.). Thus the delivery of 1 ml medicine requires about 100 As. If this amount of medicine is to be delivered within 24 hours, an electrode feeding current of about 1.25 mA is required.
  • the deviation of the diaphragm 2 does not take place by osmotic pressure in chamber 4, but a gas is produced electrolytically in chamber 4, which with increased volume moves the diaphragm 2 correspondingly into the medicine space 3.
  • the electrolytic gas producer consists simply of an inert electrode for gas separation, for example, a precious metal electrode (platinum), as well as a counter electrode 21 (silver/silver chloride or zinc electrode). Between the electrodes 20, 21 a fixed electrolite 22 is located. The current feeding of the electrodes takes place through the battery connections 23 and 24.
  • the movable diaphragm 2 of FIG. 3 is not flat but is partially folded.
  • this difference is only a variant of the diaphragm construction of FIGS. 1 and 2 and has no significance for the basic working principle of the device of the present invention.
  • two narrow conically outwardly extending bore holes 25, 26 are provided for filling medicine in the medicine containing chamber 3 and for emptying liquid or gas in the chamber 4, the holes being closed by spring valves 27 and 28.
  • a precisely fitting also conical injection needle is introduced into this opening or 26, which then opens automatically the valve 27 or 28 and by means of which the medicine container chamber 3 can befilled again or gas or liquid can be removed from the I Since the outflow opening is to be made as a narrow capillary; only small amounts of medicine which are within permissible tolerance limits can flow out during the refilling procedure due to variations in pressure.
  • a device for supplying medicines to the body of man or beast comprising means forming a first container of'variable volume for containing a medicine and having an opening for delivery of medicine. means connected with the first-mentioned means and forming a second container of variable volume to vary the volume of the first-mentioned container. and means supplying volume varying means to the second mentioned container said volume varying means for said second container having a diaphragm window for receiving said volume varying means having two electrodes of different potentials and located on opposite sides of saiddiaphragm window and being embedded between said electrodes to provide a current or voltage supply for producing electrical fields so that fluid particles are transmitted into said second container in an electroosmotic manner.
  • volume varying means comprise means electrolytically developing gas in the second-mentionedcontainer.
  • first-mentioned and the second-mentioned means jointly constitute a rigid casing having a separating wall dividing the interior of said easing into the firstmentioned container and the second-mentioned container, said separating wall pressing into the firstmentioned container when the second-mentioned container receives an excess of said volume varying means.
  • the diaphragm window of the second-mentioned container is semipermeable and consists of a substance selected from the class consisting of hydrophobic material, hydrophilic material, porous teflon, non-porous teflon, polyethylene, silicon. cellulose, cellulose derivatives and ion exchangers.
  • said diaphragm window consists of electrically charged material transmitting water. steam and ions. said electrodes producing current of such polarity that water is transmitted into the second-mentioned casing in an electro-osmotic manner.
  • said electrodes are current producing electrodes and consist of a combination of a metallic electrode as anode of zinc, cadmium or aluminum with a silver/silver chloride or oxygen/carbon electrode as cathode or a combination of a selective oxygen electrode and a glucose electrode.
  • means electrolytically developing gas comprise a precious metal inert electrode and a counter electrode selected from the class consisting of a silver/silver chlo-' ride electrode and a zinc electrode.
  • a device in accordance with claim 8. comprising an electronic steering and regulating device for steering and regulating the current between said electrodes depending upon measured value signals received from the body. said signals producing a measure for the size of the body to be influenced by the medicine.
  • said casing consists of a substance impermeable to liquid and having at least an outer surface adaptable to tissue for transplanting it into a body.
  • a device in accordance with claim 1. comprising a plug closing said opening and consisting of a finely porous material.
  • a device for supplying medicines to the body of man or beast comprising means forming a first container of variable volume for preserving a medicine and having an opening for delivery of medicine. means connectcd with the first-mentioned means and forming a second container of variable volume for varying the volume of the first container. and a device supplying volume varying means to the second container.
  • said volume varying device comprising a diaphragm window for said second container. which consists of electrically charged material transmitting particles. such as of water. steam and ions.
  • said electrodes comprising a current or voltage supply for producing current of such polarity between such electrodes. that particles. such as of water. are transmitted into the second container in an electro-osmotic manner.
  • said cur rent or voltage supplying means comprising a device. such as a potentiometer. for varying the extent of current between electrodes.
  • electrodes are current producing electrodes and consist of a combination of a metallic electrode as anode of zinc. cadmium or aluminum with a silver/silver chloride or oxygen/carbon electrode as cathode.
  • said electrodes are current producing electrodes and consist of a combination of a selective oxygen electrode and a glucose electrode.
  • said electrode current or voltage supply comprises an electronic control device for controlling current between said electrodes depending upon measured value signals received from the body, said signals producing a measure for a variable quantity or parameter inside the body to be influenced bythe medicine.

Abstract

A device for supplying medicines or the like to the body of man or beast has a container for preserving a medicine as well as means for changing the volume of the container. The container has an opening through which the medicine is ejected when the volume of the container is diminished. The invention is particularly characterized by the provision of another container operatively joined to the first-mentioned container and having a variable volume for varying the volume of the first-mentioned container. The change in volume of the other container is produced by gas or liquid particles diffused or entering through electrical fields or by electrolytical gas development within the container.

Description

United States Patent 1191 Richter 1 July 15, 1975 DEVICE FOR SUPPLYING MEDICINES [75] Inventor: Gerhard Richter, Erlangen, Germany [22] Filed: Aug. 6, 1973 [211 App]. No.: 386,058
[30] Foreign Application Priority Data Aug. 10, 1972 Germany 2239432 [52] US. Cl. 128/260; 204/301; 128/214 F; 128/272; l28/2.1 E; l28/2.1 R; 128/218 R; 222/95 [51] Int. Cl A61m 31/00 [58] Field of Search l28/171.1, 127-131, 128/260, 272, 2.1 E, 2 R, 213, 2.1 R, 218 R,
3,518,179 6/1970 Bleak et a1. 204/195 P 3,604,417 9/1971 Stolzenberg 128/213 3,659,600 5/1972 Merrill 128/260 3,732,865 5/1973 Higuchi et al. 128/260 3,760,804 9/1973 Higuchi et al. 128/260 3,760,805 9/1973 Higuchi 128/260 3,760,984 9/1973 Theeuwes 222/95 Primary Examiner-Aldrich F. Medbery Attorney, Agent, or Firm-V. Alexander Scher [57] ABSTRACT A device for supplying medicines or the like to the body of man or beast has a container for preserving a medicine as well as means for changing the volume of the container. The container has an opening through which the medicine is ejected when the volume of the container is diminished. The invention is particularly characterized by the provision of another container operatively joined to the first-mentioned container and having a variable volume for varying the volume of the first-mentioned container. The change in volume of the other container is produced by gas or liquid particles diffused or entering through electrical fields or by electrolytical gas development within the container.
20 Claims, 3 Drawing Figures [56] References Cited UNITED STATES PATENTS 2,913,386 11/1959 Clark,.lr ..204/195P 3,023,750 3/1962 Baron 128/214F 3,050,665 8/1962 Hurd ..204/231 3,485,235 12/1969 Felson 128/2 V 1 f 13 9 16 3 4-6 10 15 I? 11 12 '1 DEVICE FOR SUPPLYING MEDICINES This invention relates to a device for supplying medicines or the like to the body of man or beast. having a container for preserving a medicine as well as means for changing the volume of the container. The container has an opening through which the medicine is ejected when the volume of the container is diminished. The term medicine as used herein is intended to cover all substances which are used to improve. reinstate or maintain the health of a patient. such as for example. vitamins or hormones.
During many illnesses the patients must be provided with medicines for lengthy time periods. for example. insulin for diabetes. corticosteroides for rheumatic illnesses. cytostatics for cancer. blood pressure regulators or also sex hormones. Up to now the supply of these medicines to the body of the patient took place primarily either orally (by swallowing tablets) or by simple injection at certain time intervals. Thus this supply of medicines is a discontinuous one and is poorly adapted to the actual requirements of the patient. When the patient provides himself with the medicines. the correct dosage is not always provided. However. in case of many medicines a very precise dosage is most important. since an excess of the medicine or insufficient dosage can have detrimental effects. Thus. for example. an insufficient amount of insulin causes comadiabetics. while an excess produces a hypoglycaumic shock. A lack of precision in the dosing of insulin probably causes an inclination of diabetics to arteriosclerosis.
An object of the present invention is the provision of a device which is operable without the assistance of a doctor or the use of the patient for providing automatically for long time periods a comparatively precise dosage of a medicine.
Other objects will become apparent in the course of the following specification.
ln the accomplishment of the objectives of the present invention it was found desirable to operatively combine with the container of the described type another container of variable volume serving as means for varying the volume of the medicine-carrying container. The change in volume of the second container is produced by gas or liquid particles diffused or entering through electrical fields or by electrolytical gas development within the container.
The regulation of the delivery of medicine out of the medicine-carrying container by a change in volume of another container operatively connected with the medicine carrying container, makes it possible to provide with the simplest technical means an extremely precise dosage of the medicine being delivered for long time periods. since volume changes of a container as such can be continuously precisely produced in a simple manner and can be controlled. The changes in volume actuated by gas or liquid particles diffused or entering through electrical fields or by electrolytical gas development, is particularly advantageous since such flows have an extremely precise uniformity over long time periods, so that changes in volume of the container regulating the delivery of the medicine out of the medicine carrying container also have a high extent of continuity over long time periods. Furthermore. the dosage of the medicine can be made extremely fine, since the gas or liquid diffused or field currents or electrolytically produced gas currents causing the passage of medicine out of the medicine-carrying container can be kept extremely small by suitable shaping or measuring of the gas or liquid diffusion passage or of the electrolytic gas developer in the container.
in accordance with the present invention the medicine-carrying container can be made totally or partly of elastic material and means can be provided for transforming volume changes of the other container into a compressing force exerted upon the elastic material. The other container can press with at least a part of its walls directly upon the elastic material of the medicinecarrying container. For that purpose the medicinecarrying container is preferably placed within the main container or so arranged that at least the elastic part of the medicine-carrying container constitutes at the same time a part of the wall of the main container.
According to a preferred embodiment of the present invention the main container has a rigid casing the interior of which is divided by a separating wall into two chambers one of which has an outflow opening and is used to receive the medicine. while the second one has a diaphragm window through which gas or liquid particles can be diffused or entered by electrical field action or which can contain a gas producer for electrolytic gas separation. whereby the separating wall can be pushed into the first chamber due to an increase of gas or liquid in the second chamber. The diffusion or entry of gas or liquid particles into the second chamber preferably takes place either in the usual osmotic manner or in the electro-osmotic manner.
While the normal osmotic diffusion effect permits substantially only a dosage of the medicine to be used extending continuously over the entire duration of the treatment. the electro-osmotic effect as well as the electrolytic gas production in a further container permit a-medicine dosage which can be operated or regulated from the outside to a certain extent. by setting currents of different strengths between electrodes required for producing the electro-osmotic effect or for electrolytic gas separation. The operation or regulation of the. dosage can take place preferably by measure value-signals which are obtained from or in the body of the patient and constitute a measure for the size of the body to be affected by the medicine.
Thedevice of the present invention is paticularly suitable for implantation into the body of a patient. However, it can be obviously used outside of the body. for example. by being carried upon the surface of the body.
.-'The invention will appear more clearly from the following detailed description. when taken in connection with the accompanying drawing showing by way of example. only. preferred embodiments of the inventive idea.
ln the drawing:
FIG. 1 is a section through an implantable device of the present invention operating according to normal osmose.
FIG. 2 is a section through an implantable device of the present invention operating according to electroosmose.
FIG. 3 is a section through an implantable device of the present invention wherein changes in volume of the container actuating the medicine-carrying container are caused by gases produced electrolytically in the container.
The casings are indicated by the numeral 1 in the 3 not transmit liquid and is well adapted. to tissue, for example. epoxide resin. I l
The interior of the casing l is divided by a diaphragm 2 into two separate chambers 3- and 4, whereby .the chamber 3 is used for receiving a medicine. for example. insulin for treating diabetes. while chamber 4 serves for creating osmotic pressure as the result of which the diaphragm 2 is slowly pressed into the chamber 3 and thus by this extension presses the medicine located in the'chamber 3 through an outflow opening 5 provided in the container. The diaphragm 2 consists of a liquid-tight material. preferably a -plastic. and is elastic. It is also possible to additionally metallize the diaphragm 2 as well as the interior of the medicine containing chamber 3 to provide greater im'permeability against liquids and to prevent possible chemical reactions of the medicine with the material of the casing or diaphragm, v
The liquid medicine driven through the opening S'is transported through a thin tube 6 connected to the opening 5 to a suitable location in the body of the patient. for example. into the blood flow, and is there released. The free end of the tube 6 is preferably provided with a finely porous plug 7 which prevents return diffusion of the body liquid into the medicinecontaining chamber 3 or an uncontrolled outflow of the medicine out of the chamber 3. The plug can consist of porous teflon or a hydrophylic material. such as cellulose. or an ion exchanging material. The width of the pores of the plug material shouldbe less than lOOum. preferably between 1 and 20am.
In the embodiment illustrated in FIG. 1 the creation of osmotic pressure in the chamber 4 takes place in a normal osmotic manner. For that purposethe wall of the chamber 4 is provided with a diaphragm window 8 consisting of a semi-permeable material which can transmit water or steam. and also small loose molecules or ions. but not the substance located within the chamber4 and used to buildup osmotic pressure in the chamber. I
The window 8 can be either rigid or can be held by porous rigid supports. preventing it from moving outwardly when pressure is increased. The material of the diaphragm can be either a hydrophobic material. for example. porous or also nonporous teflon, polyethylene or silicon. or the diaphragm can consist of a hydrophilic material. for example, cellulose. cellulose derivatives or ion exchangers. lf porous teflon is used as the diaphragm material. then the width of its individual pores must be narrower than the width of the pores of the material of the plug located at the outlet of the medicine transmitting tube 6.
To make certain that there will be a uniform and fine outflow of the medicine out of the ,chamber 3, the steam pressure in the chamber 4 must be small relatively to steam pressure in the body liquid surrounding the casing 1. Furthermore. changes of steam pressure in the pressure chamber must remain small during the operational period, compared with the steam pressure difference relatively to body liquid. The dosage of the medicine is then determined by the extent of diffusion of water or steam in the chamber 4. The extent of transmission of the semipermeable window 8, its size and with low steam partial pressure for the interior of the chamber 4.
If av material. is selected for the diaphragm window which transmits, ions, then the interior of the chamber 4 should be filled with a polyelectrolite or a gel. The osmotic pressure is then produced due to a so-called Donnan weight balance.
In the construction shown in FIG. 2 osmotic pressure in the chamber 4 is produced by an electro-osmotic effect. For that purpose the wall of the casing of the chamber 4 is provided with a diaphragm window 9 which is electrically charged and transmits ions. The window 9 is fixed between two electrodes 10 and 11 which produce a current through the window. The electrodes must be so polarized that counter ions move inwardly through the window to the solid ions, namely in the direction toward the chamber 4. If, for example, the window has cation exchange properties, then the electrode 10 must be polarized negatively and the electrode 11 must be polarized positively. When the electrodes 10' and 11 lie directly upon both sides of the window 9, they must be also made porous and filled with an electrolite, so that the electro-osmotic transportation of water through them'can take place. Furthermore. the-electrode 11 should be screened by a diaphragm 12 transmitting ions and suitable for tissue to avoid its contact with bodily tissue. v
The electrodes 10, 11 can be supplied with outside vcurrent, for example. by a battery 13 through a potentiometer 14 which can be connectedby outlet contacts 15 and 16 with the current connecting contacts 17 and 18 of the electrodes 10 and ll. If the electrodes consist of an inert material. such as platinum, then care must be taken that the. feeding current should not exceed the amount of l mA/cm so that no gas development should take place (diffusion limit current).
However. the electrodes '10 and 11 can be advantageously so constructed that they themselves will supply the current. For that purpose an electrode consisting for example of zinc. cadmium, aluminum or glucose can be used as anode and as cathode can be a silver/silver chloride or an oxygen/carbon electrode. In case of a combination of a glucose electrode with an oxygen electrode, the glucose electrode which, for example, consists of platinum black or Raney-platinumruthenium, must be applied to the side facing the chamber 4 of the hydrophilic window constructed as anion exchanger (electrode 10). The oxygen electrode consists of porous charcoal and is located upon the outer side of the window 9 (electrode 11). Since the coal electrode-is selective and reacts only with oxygen, the glucose is diffused without hindrance through the coal electrode and the window 9 to the non-selective precious metal electrode and can be reacted there. When a resistance 19 is connected, preferably a potentiometer for setting different cell currents, a current will flow between the electrodes.
The use of device devide ofthe'present invention 7 having a glucose-oxygen-electrode combination is par- 7 current between the electrodes is also directly depenthickness are to be selected depending upon the Ldesired dosage. A hygroscopic salt, such as ,rnagnes'ium-. Zincor calcium chloride, is suggested as-a substance dent froin'theglucose content of the tissue liquid of the patientlfa more or less strong current corresponding to height of the blood glucose mirror is produced in 'a' tim e'un it through the window, and thus more or less 'wateris fdiffu se cl in thesame timeperiod into the chamher 4 and thus due to a more or less quick filling of this space 4 a correspondingly strong or less strong insulin is transmitted through the opening 5 and tube 6' to the blood of the patient. Thus a device of this type carries out already by itself a certain regulating function with respect to an increased insulin delivery at a higher glucose mirror and a correspondingly weaker insulin delivery at a correspondingly lower glucose mirror.
However, even when other types of medicine are used it is possible to operate or regulate a corresponding adaptation of medicine delivery to the momentary requirement of the patient. by providing means which continuously supervise the body section to be influenced by the medicine and produce corresponding measuring signals which can be then used for operating or regulating the electrode current, for example. by correspondingly actuating the potentiometer 14 or 19. In case of a regulation as intended value is then used a normal value of the body size and the medicine delivery is regulated on the basis of body size signal-actual value-intended value deviation (over the current).
The amount of medicine which should be transmitted from the medicine container 3 into the tissue or blood of a patient corresponds to the amount ofsolution (water and ions) which is transmitted through the diaphragm window 8 or 9 into the chamber 4. In. the embodiment of the invention illustrated in FIG. 2 this amount of solution and thus the delivered amount of medicine are determined directly by the strength of electro-osmotically actuating current. For example. per Faraday (96500 As) are transported by a cation exchange diaphragm at a current strength of l mA/cm 50 mol of solution (corresponding to 90 gr.). Thus the delivery of 1 ml medicine requires about 100 As. If this amount of medicine is to be delivered within 24 hours, an electrode feeding current of about 1.25 mA is required.
In the embodiment shown in FIG. 3, as distinguished from those of FIGS. 1 and 2, the deviation of the diaphragm 2 does not take place by osmotic pressure in chamber 4, but a gas is produced electrolytically in chamber 4, which with increased volume moves the diaphragm 2 correspondingly into the medicine space 3. The electrolytic gas producer consists simply of an inert electrode for gas separation, for example, a precious metal electrode (platinum), as well as a counter electrode 21 (silver/silver chloride or zinc electrode). Between the electrodes 20, 21 a fixed electrolite 22 is located. The current feeding of the electrodes takes place through the battery connections 23 and 24.
Contrary to the embodiments of FIGS. 1 and 2, the movable diaphragm 2 of FIG. 3 is not flat but is partially folded. However, this difference is only a variant of the diaphragm construction of FIGS. 1 and 2 and has no significance for the basic working principle of the device of the present invention.
As shown in FIGS. 1 and 2, two narrow conically outwardly extending bore holes 25, 26 are provided for filling medicine in the medicine containing chamber 3 and for emptying liquid or gas in the chamber 4, the holes being closed by spring valves 27 and 28.
For example, a precisely fitting also conical injection needle is introduced into this opening or 26, which then opens automatically the valve 27 or 28 and by means of which the medicine container chamber 3 can befilled again or gas or liquid can be removed from the I Since the outflow opening is to be made as a narrow capillary; only small amounts of medicine which are within permissible tolerance limits can flow out during the refilling procedure due to variations in pressure.
I claim:
l. A device for supplying medicines to the body of man or beast. comprising means forming a first container of'variable volume for containing a medicine and having an opening for delivery of medicine. means connected with the first-mentioned means and forming a second container of variable volume to vary the volume of the first-mentioned container. and means supplying volume varying means to the second mentioned container said volume varying means for said second container having a diaphragm window for receiving said volume varying means having two electrodes of different potentials and located on opposite sides of saiddiaphragm window and being embedded between said electrodes to provide a current or voltage supply for producing electrical fields so that fluid particles are transmitted into said second container in an electroosmotic manner. r
2. A device in accordance with claim 1, wherein said volume varying means comprise means electrolytically developing gas in the second-mentionedcontainer.
3. A device in accordance with claim 2, wherein the first-mentioned and the second-mentioned means jointly constitute a rigid casing having a separating wall dividing the interior of said easing into the firstmentioned container and the second-mentioned container, said separating wall pressing into the firstmentioned container when the second-mentioned container receives an excess of said volume varying means.
4. A device in accordance with claim 1, wherein the diaphragm window of the second-mentioned container is semipermeable and consists of a substance selected from the class consisting of hydrophobic material, hydrophilic material, porous teflon, non-porous teflon, polyethylene, silicon. cellulose, cellulose derivatives and ion exchangers.
5. A device in accordance with claim 1, wherein said diaphragm window consists of electrically charged material transmitting water. steam and ions. said electrodes producing current of such polarity that water is transmitted into the second-mentioned casing in an electro-osmotic manner.
6. A device in accordance with claim 5, having means supplying a current to said electrodes and having a potentiometer varying-the extent of this current.
7. A device in accordance with claim 5, wherein said electrodes are current producing electrodes and consist of a combination of a metallic electrode as anode of zinc, cadmium or aluminum with a silver/silver chloride or oxygen/carbon electrode as cathode or a combination of a selective oxygen electrode and a glucose electrode.
8. A device in accordance with claim 2, wherein means electrolytically developing gas comprise a precious metal inert electrode and a counter electrode selected from the class consisting of a silver/silver chlo-' ride electrode and a zinc electrode.
9. A device in accordance with claim 8. comprising an electronic steering and regulating device for steering and regulating the current between said electrodes depending upon measured value signals received from the body. said signals producing a measure for the size of the body to be influenced by the medicine.
10. A device in accordance with claim 3. wherein said casing consists of a substance impermeable to liquid and having at least an outer surface adaptable to tissue for transplanting it into a body.
11. A device in accordance with claim 1. comprising a plug closing said opening and consisting of a finely porous material.
12. A device in accordance with claim 11, wherein the pores of said material range between 1 ,u. and p. and are less than l()() p" 13. A device for supplying medicines to the body of man or beast. comprising means forming a first container of variable volume for preserving a medicine and having an opening for delivery of medicine. means connectcd with the first-mentioned means and forming a second container of variable volume for varying the volume of the first container. and a device supplying volume varying means to the second container. said volume varying device comprising a diaphragm window for said second container. which consists of electrically charged material transmitting particles. such as of water. steam and ions. and further comprising at least two electrodes locatedon opposite sides of said diaphragm window, said diaphragm window being embedded between said electrodes. said electrodes comprising a current or voltage supply for producing current of such polarity between such electrodes. that particles. such as of water. are transmitted into the second container in an electro-osmotic manner.
g 14. A device in accordance with claim' 13, wherein the diaphragm window of the second container is semipermeable and consists of a substance selected from the class consisting of hydrophilic material, such as cellulose, cellulose derivatives and ion exchangers.
15. A device in accordance with claim 13, said cur rent or voltage supplying means comprising a device. such as a potentiometer. for varying the extent of current between electrodes.
I 16. A device in accordance with claim l3,'wherein said electrodes are current producing electrodes and consist of a combination of a metallic electrode as anode of zinc. cadmium or aluminum with a silver/silver chloride or oxygen/carbon electrode as cathode.
17. A device in accordance with claim 13, wherein said electrodes are current producing electrodes and consist of a combination of a selective oxygen electrode and a glucose electrode.
18. A device in accordance with claim 13, wherein said electrode current or voltage supply comprises an electronic control device for controlling current between said electrodes depending upon measured value signals received from the body, said signals producing a measure for a variable quantity or parameter inside the body to be influenced bythe medicine.-
19. A device in accordance with claim 18, wherein tween 1 pm and 20 um.

Claims (20)

1. A device for supplying medicines to the body of man or beast, comprising means forming a first container of variable volume for containing a medicine and having an opening for delivery of medicine, means connected with the first-mentioned means and forming a second container of variable volume to vary the volume of the first-mentioned container, and means supplying volume varying means to the second mentioned container said volume varying means for said second container having a diaphragm window for receiving said volume varying means having two electrodes of different potentials and locAted on opposite sides of said diaphragm window and being embedded between said electrodes to provide a current or voltage supply for producing electrical fields so that fluid particles are transmitted into said second container in an electro-osmotic manner.
2. A device in accordance with claim 1, wherein said volume varying means comprise means electrolytically developing gas in the second-mentioned container.
3. A device in accordance with claim 2, wherein the first-mentioned and the second-mentioned means jointly constitute a rigid casing having a separating wall dividing the interior of said casing into the first-mentioned container and the second-mentioned container, said separating wall pressing into the first-mentioned container when the second-mentioned container receives an excess of said volume varying means.
4. A device in accordance with claim 1, wherein the diaphragm window of the second-mentioned container is semipermeable and consists of a substance selected from the class consisting of hydrophobic material, hydrophilic material, porous teflon, non-porous teflon, polyethylene, silicon, cellulose, cellulose derivatives and ion exchangers.
5. A device in accordance with claim 1, wherein said diaphragm window consists of electrically charged material transmitting water, steam and ions, said electrodes producing current of such polarity that water is transmitted into the second-mentioned casing in an electro-osmotic manner.
6. A device in accordance with claim 5, having means supplying a current to said electrodes and having a potentiometer varying the extent of this current.
7. A device in accordance with claim 5, wherein said electrodes are current producing electrodes and consist of a combination of a metallic electrode as anode of zinc, cadmium or aluminum with a silver/silver chloride or oxygen/carbon electrode as cathode or a combination of a selective oxygen electrode and a glucose electrode.
8. A device in accordance with claim 2, wherein means electrolytically developing gas comprise a precious metal inert electrode and a counter electrode selected from the class consisting of a silver/silver chloride electrode and a zinc electrode.
9. A device in accordance with claim 8, comprising an electronic steering and regulating device for steering and regulating the current between said electrodes depending upon measured value signals received from the body, said signals producing a measure for the size of the body to be influenced by the medicine.
10. A device in accordance with claim 3, wherein said casing consists of a substance impermeable to liquid and having at least an outer surface adaptable to tissue for transplanting it into a body.
11. A device in accordance with claim 1, comprising a plug closing said opening and consisting of a finely porous material.
12. A device in accordance with claim 11, wherein the pores of said material range between 1 Mu and 20 Mu and are less than 100 Mu .
13. A device for supplying medicines to the body of man or beast, comprising means forming a first container of variable volume for preserving a medicine and having an opening for delivery of medicine, means connected with the first-mentioned means and forming a second container of variable volume for varying the volume of the first container, and a device supplying volume varying means to the second container, said volume varying device comprising a diaphragm window for said second container, which consists of electrically charged material transmitting particles, such as of water, steam and ions, and further comprising at least two electrodes located on opposite sides of said diaphragm window, said diaphragm window being embedded between said electrodes, said electrodes comprising a current or voltage supply for producing current of such polarity between such electrodes, that particles, such as of water, are transmitted into the second container in an electro-osmotic manner.
14. A device iN accordance with claim 13, wherein the diaphragm window of the second container is semipermeable and consists of a substance selected from the class consisting of hydrophilic material, such as cellulose, cellulose derivatives and ion exchangers.
15. A device in accordance with claim 13, said current or voltage supplying means comprising a device, such as a potentiometer, for varying the extent of current between electrodes.
16. A device in accordance with claim 13, wherein said electrodes are current producing electrodes and consist of a combination of a metallic electrode as anode of zinc, cadmium or aluminum with a silver/silver chloride or oxygen/carbon electrode as cathode.
17. A device in accordance with claim 13, wherein said electrodes are current producing electrodes and consist of a combination of a selective oxygen electrode and a glucose electrode.
18. A device in accordance with claim 13, wherein said electrode current or voltage supply comprises an electronic control device for controlling current between said electrodes depending upon measured value signals received from the body, said signals producing a measure for a variable quantity or parameter inside the body to be influenced by the medicine.
19. A device in accordance with claim 18, wherein said variable quantity or parameter is glucose inside said body and said medicine preserved by said first container is insulin.
20. A device in accordance with claim 13, comprising a plug closing said opening in said first container for delivery of medicine and consisting of a finely porous material, wherein the pores of said material range between 1 Mu m and 20 Mu m.
US386058A 1972-08-10 1973-08-06 Device for supplying medicines Expired - Lifetime US3894538A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722239432 DE2239432C3 (en) 1972-08-10 Device for the delivery of medication

Publications (1)

Publication Number Publication Date
US3894538A true US3894538A (en) 1975-07-15

Family

ID=5853263

Family Applications (1)

Application Number Title Priority Date Filing Date
US386058A Expired - Lifetime US3894538A (en) 1972-08-10 1973-08-06 Device for supplying medicines

Country Status (7)

Country Link
US (1) US3894538A (en)
AT (1) AT345438B (en)
CH (1) CH557178A (en)
FR (1) FR2195461B1 (en)
GB (2) GB1452104A (en)
NL (1) NL7310455A (en)
SE (1) SE419406B (en)

Cited By (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077405A (en) * 1975-03-26 1978-03-07 Siemens Aktiengesellschaft Apparatus for infusing liquids into human or animal bodies
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4159720A (en) * 1977-11-28 1979-07-03 Burton Andrew F Infusion of liquids into tissue
US4204538A (en) * 1978-06-07 1980-05-27 Imed Corporation Cassette for intravenous controller
US4205676A (en) * 1978-03-13 1980-06-03 Deley C. Humphrey Air pumping for medical uses
US4217894A (en) * 1977-05-13 1980-08-19 Siemens Aktiengesellschaft Apparatus for supplying medication to the human or animal body
US4265241A (en) * 1979-02-28 1981-05-05 Andros Incorporated Implantable infusion device
US4382753A (en) * 1979-03-09 1983-05-10 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
WO1983002063A1 (en) * 1981-12-07 1983-06-23 Univ Johns Hopkins Refillable medication infusion apparatus
US4391600A (en) * 1979-03-09 1983-07-05 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4410322A (en) * 1979-03-09 1983-10-18 Avi, Inc. Nonpulsating TV pump and disposable pump chamber
EP0091621A1 (en) * 1982-04-05 1983-10-19 Milliken Research Corporation Low flow constant rate pump
DE3333977A1 (en) * 1982-09-20 1984-03-22 Infusaid Corp., Norwood, Mass. INFUSION PUMP
DE3247232A1 (en) * 1979-04-27 1984-07-05 The Johns Hopkins University, Baltimore, Md. INFUSION SYSTEM FOR MEDICAL SUPPLY
US4559037A (en) * 1977-12-28 1985-12-17 Siemens Aktiengesellschaft Device for the pre-programmable infusion of liquids
WO1986003418A1 (en) * 1984-12-06 1986-06-19 Tran Loi H Therapeutic agent delivery system and method
US4596575A (en) * 1983-08-04 1986-06-24 Omikron Scientific Ltd. Liquid delivery system particularly useful as an implantable micropump for delivering insulin or other drugs
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
EP0209677A1 (en) * 1985-06-07 1987-01-28 Ivac Corporation Electrochemically-driven pulsatile drug dispenser
US4655765A (en) * 1984-06-01 1987-04-07 Parker Hannifin Corporation Fitting with prestressed septum
US4697622A (en) * 1984-06-01 1987-10-06 Parker Hannifin Corporation Passive filling device
EP0259013A1 (en) * 1986-08-04 1988-03-09 Pharmetrix Corporation Portable controlled release osmotic infusion device
US4820273A (en) * 1988-03-01 1989-04-11 Eaton Corporation Implantable medication infusion device and bolus generator therefor
US4857048A (en) * 1987-05-29 1989-08-15 Hewlett-Packard Company IV pump and disposable flow chamber with flow control
AU587877B2 (en) * 1985-11-22 1989-08-31 Industrikontakt Ing. O. Ellingsen & Co. An artificial gland for implantation in the human body
US4886514A (en) * 1985-05-02 1989-12-12 Ivac Corporation Electrochemically driven drug dispenser
US4902278A (en) * 1987-02-18 1990-02-20 Ivac Corporation Fluid delivery micropump
US4941873A (en) * 1979-07-25 1990-07-17 Ultradent Products, Inc. Controlled diffusion medicament applicator
US4997371A (en) * 1988-06-22 1991-03-05 Honda Giken Kogyo Kabushiki Kaisha Dental agent applicator
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5090963A (en) * 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser
DE3390255C2 (en) * 1982-11-04 1992-06-25 Univ Johns Hopkins Implanted medication infusion appts. with pulsatile pump
US5242406A (en) * 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
US5246371A (en) * 1992-08-31 1993-09-21 Ultradent Products, Inc. Method and apparatus for delivery of highly filled, thixotropic sealant to teeth
US5269684A (en) * 1992-08-31 1993-12-14 Ultradent Products, Inc. Adjustable brush delivery tip with secondary flow path
US5397303A (en) * 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
US5398851A (en) * 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5423454A (en) * 1992-08-19 1995-06-13 Lippman, Deceased; Lawrence G. Method of propellant gas generation
US5571261A (en) * 1993-08-06 1996-11-05 River Medical, Inc Liquid delivery device
US5578005A (en) * 1993-08-06 1996-11-26 River Medical, Inc. Apparatus and methods for multiple fluid infusion
US5584667A (en) * 1988-05-17 1996-12-17 Davis; David L. Method of providing uniform flow from an infusion device
WO1996041159A1 (en) * 1995-06-07 1996-12-19 Ceramatec, Inc. Gas amplifier
WO1997013007A1 (en) 1995-10-06 1997-04-10 Ceramatec, Inc. Storage-stable, fluid dispensing device using a hydrogen gas generator
US5766147A (en) * 1995-06-07 1998-06-16 Winfield Medical Vial adaptor for a liquid delivery device
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
US5803712A (en) * 1988-05-17 1998-09-08 Patient Solutions, Inc. Method of measuring an occlusion in an infusion device with disposable elements
US5836935A (en) * 1994-11-10 1998-11-17 Ashton; Paul Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
WO1999006614A1 (en) 1996-07-23 1999-02-11 Microlin, L.C. Storage stable electrolytic gas generator for fluid dispensing applications
US5899381A (en) * 1997-02-21 1999-05-04 Ceramatec, Inc. Electrochemical device for delivery of volatile substances
US5925030A (en) * 1994-08-15 1999-07-20 Elan Corporation, Plc Orally administrable delivery device
US5938640A (en) * 1997-06-04 1999-08-17 M&R Consulting Services Two-part fluid dispenser
US5939032A (en) * 1996-06-20 1999-08-17 Samsung Electronics Co., Ltd. Apparatus and method for on-line decomposition of hydrogen peroxide solution in fabrication of semiconductor device
US5964261A (en) * 1996-05-29 1999-10-12 Baxter International Inc. Implantation assembly
US6060196A (en) * 1995-10-06 2000-05-09 Ceramtec, Inc. Storage-stable zinc anode based electrochemical cell
WO2000074751A1 (en) * 1999-06-08 2000-12-14 Medical Research Group, Inc. Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device
WO2002099345A1 (en) * 2001-06-06 2002-12-12 Nanopore, Inc. Sorption cooling devices and temperature-controlled shipping containers incorporating sorption cooling devices
WO2003018089A1 (en) * 2001-08-31 2003-03-06 Institute Of Materials Research And Engineering Liquid delivering device
US20030082415A1 (en) * 2001-10-30 2003-05-01 Joshi Ashok V. Hydrogen generating cell with cathode
US20030083641A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Impedance sensor
FR2836520A1 (en) * 2002-02-28 2003-08-29 Univ Joseph Fourier Osmotic actuator
US20030205582A1 (en) * 2002-05-01 2003-11-06 Joshi Ashok V. Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method
US20040007456A1 (en) * 2002-07-15 2004-01-15 Holstun Clayton L. Generation of gas in a lab-on-a-chip environment
US20040018095A1 (en) * 2002-07-25 2004-01-29 Smekal Thomas J. Fluidic pump
US20040230183A1 (en) * 2003-02-18 2004-11-18 Wisam Breegi Drug delivery device and syringe for filling the same
US20050038415A1 (en) * 2003-08-06 2005-02-17 Rohr William L. Method and apparatus for the treatment of obesity
US7008403B1 (en) 2002-07-19 2006-03-07 Cognitive Ventures Corporation Infusion pump and method for use
US20060052768A1 (en) * 2002-05-01 2006-03-09 Microlin, L.C. Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US20060116641A1 (en) * 2002-05-01 2006-06-01 Microlin, L.C. Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US20060116663A1 (en) * 2002-05-01 2006-06-01 Joshi Ashok V Electro-osmotic fluid delivery device and method
FR2881481A1 (en) * 2005-02-03 2006-08-04 Univ Grenoble 1 Osmotic actuator to palliate the deficiency of heart muscle, respiratory muscles and sphincters, comprises an enclosure with wall which is non-permeable to a solute and permeable to a solvent, and a deformable chamber
US20060189939A1 (en) * 2000-11-30 2006-08-24 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
US20060207883A1 (en) * 2004-10-19 2006-09-21 Koval Carl A Electrochemical high pressure pump
US20060264897A1 (en) * 2005-01-24 2006-11-23 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20060280655A1 (en) * 2005-06-08 2006-12-14 California Institute Of Technology Intravascular diagnostic and therapeutic sampling device
US20070021734A1 (en) * 2005-07-15 2007-01-25 Sai Bhavaraju Bioelectro-osmotic engine fluid delivery device
EP1778335A2 (en) * 2004-08-04 2007-05-02 ExploraMed NC1, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
WO2007125456A2 (en) * 2006-04-28 2007-11-08 Koninklijke Philips Electronics N. V. Micropump with at least one gas releasing material
US20070287984A1 (en) * 2006-06-09 2007-12-13 Neurosystec Corporation Flow-Induced Delivery from a Drug Mass
US20080065002A1 (en) * 2006-09-07 2008-03-13 Neurosystec Corporation Catheter for Localized Drug Delivery and/or Electrical Stimulation
US20080147007A1 (en) * 2006-12-19 2008-06-19 Toby Freyman Delivery device with pressure control
US20080152694A1 (en) * 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
US20080243140A1 (en) * 2001-02-06 2008-10-02 Acclarent, Inc. Spacing devices for releasing active substances in the paranasal sinus
US20090191067A1 (en) * 2008-01-25 2009-07-30 Phluid,Inc. Two chamber pumps and related methods
US20090198220A1 (en) * 2006-04-28 2009-08-06 Michel Paul Barbara Van Bruggen Osmotic pump with at least one chargeable material
US20090209945A1 (en) * 2008-01-18 2009-08-20 Neurosystec Corporation Valveless impedance pump drug delivery systems
US20090240215A1 (en) * 2007-12-20 2009-09-24 Mark Humayun Apparatus and methods for delivering therapeutic agents
US20090306594A1 (en) * 2008-05-08 2009-12-10 Changlin Pang Drug-delivery pumps and methods of manufacture
US20090306585A1 (en) * 2008-05-08 2009-12-10 Changlin Pang Implantable pumps and cannulas therefor
US20100032041A1 (en) * 2008-08-08 2010-02-11 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
US20100222770A1 (en) * 2005-07-01 2010-09-02 John Howard Gordon Fluid delivery device with a diffusion membrane for fast response time
US20110077579A1 (en) * 2005-03-24 2011-03-31 Harrison William V Cochlear implant with localized fluid transport
US20110112512A1 (en) * 2004-04-21 2011-05-12 Acclarent, Inc. Devices and methods for treating maxillary sinus disease
US20110184389A1 (en) * 2006-11-01 2011-07-28 Medtronic, Inc. Osmotic pump apparatus and associated methods
US20110202032A1 (en) * 2008-05-08 2011-08-18 Jason Shih Drug-delivery pumps with dynamic, adaptive control
US8080000B2 (en) 2004-04-21 2011-12-20 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US8088101B2 (en) 2004-04-21 2012-01-03 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8100933B2 (en) 2002-09-30 2012-01-24 Acclarent, Inc. Method for treating obstructed paranasal frontal sinuses
US8114113B2 (en) 2005-09-23 2012-02-14 Acclarent, Inc. Multi-conduit balloon catheter
US8114062B2 (en) 2004-04-21 2012-02-14 Acclarent, Inc. Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders
US8118757B2 (en) 2007-04-30 2012-02-21 Acclarent, Inc. Methods and devices for ostium measurement
US8142422B2 (en) 2004-04-21 2012-03-27 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US8146400B2 (en) 2004-04-21 2012-04-03 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8172828B2 (en) 2004-04-21 2012-05-08 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US8182432B2 (en) 2008-03-10 2012-05-22 Acclarent, Inc. Corewire design and construction for medical devices
US8190389B2 (en) 2006-05-17 2012-05-29 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US8287495B2 (en) 2009-07-30 2012-10-16 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8388642B2 (en) 2005-01-18 2013-03-05 Acclarent, Inc. Implantable devices and methods for treating sinusitis and other disorders
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8414473B2 (en) 2004-04-21 2013-04-09 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US8435290B2 (en) 2009-03-31 2013-05-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US8439687B1 (en) 2006-12-29 2013-05-14 Acclarent, Inc. Apparatus and method for simulated insertion and positioning of guidewares and other interventional devices
US8485199B2 (en) 2007-05-08 2013-07-16 Acclarent, Inc. Methods and devices for protecting nasal turbinate during surgery
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8702626B1 (en) 2004-04-21 2014-04-22 Acclarent, Inc. Guidewires for performing image guided procedures
US8715169B2 (en) 2004-04-21 2014-05-06 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US8747389B2 (en) 2004-04-21 2014-06-10 Acclarent, Inc. Systems for treating disorders of the ear, nose and throat
US8764729B2 (en) 2004-04-21 2014-07-01 Acclarent, Inc. Frontal sinus spacer
US8864787B2 (en) 2004-04-21 2014-10-21 Acclarent, Inc. Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis
US8894614B2 (en) 2004-04-21 2014-11-25 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US8932276B1 (en) 2004-04-21 2015-01-13 Acclarent, Inc. Shapeable guide catheters and related methods
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US8979888B2 (en) 2008-07-30 2015-03-17 Acclarent, Inc. Paranasal ostium finder devices and methods
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US9072626B2 (en) 2009-03-31 2015-07-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US9089258B2 (en) 2004-04-21 2015-07-28 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9101384B2 (en) 2004-04-21 2015-08-11 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat
US9107574B2 (en) 2004-04-21 2015-08-18 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9155492B2 (en) 2010-09-24 2015-10-13 Acclarent, Inc. Sinus illumination lightwire device
US9265407B2 (en) 2004-04-21 2016-02-23 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
US9399121B2 (en) 2004-04-21 2016-07-26 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US9433437B2 (en) 2013-03-15 2016-09-06 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9468362B2 (en) 2004-04-21 2016-10-18 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9629684B2 (en) 2013-03-15 2017-04-25 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9693894B2 (en) 2006-03-14 2017-07-04 The University Of Southern California MEMS device and method for delivery of therapeutic agents
US9820688B2 (en) 2006-09-15 2017-11-21 Acclarent, Inc. Sinus illumination lightwire device
US9849233B1 (en) * 2017-05-10 2017-12-26 Novus Medical Products, Inc. Disposable infusion pump system for ambulatory patients
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10188413B1 (en) 2004-04-21 2019-01-29 Acclarent, Inc. Deflectable guide catheters and related methods
US10206821B2 (en) 2007-12-20 2019-02-19 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US10258736B2 (en) 2012-05-17 2019-04-16 Tandem Diabetes Care, Inc. Systems including vial adapter for fluid transfer
CN109890434A (en) * 2016-11-01 2019-06-14 赛诺菲-安万特德国有限公司 Cubing component
US10524814B2 (en) 2009-03-20 2020-01-07 Acclarent, Inc. Guide system with suction
US10549030B2 (en) * 2016-09-08 2020-02-04 Eoflow Co., Ltd. Liquid medicine injection device
US20210093826A1 (en) * 2019-10-01 2021-04-01 GE Precision Healthcare LLC Anesthesia Vaporizer System Having a Variable Volume Reservoir
US11065061B2 (en) 2004-04-21 2021-07-20 Acclarent, Inc. Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US11097871B2 (en) * 2017-05-31 2021-08-24 Yoshino Kogyosho Co., Ltd. Synthetic resin container
WO2022046906A1 (en) * 2020-08-27 2022-03-03 Analog Devices, Inc. Fluid delivery system
US11529502B2 (en) 2004-04-21 2022-12-20 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US11604084B2 (en) 2021-04-15 2023-03-14 Analog Devices, Inc. Sensor package
US11796367B2 (en) 2021-05-07 2023-10-24 Analog Devices, Inc. Fluid control system

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2652026C2 (en) * 1976-11-15 1983-01-05 Siemens AG, 1000 Berlin und 8000 München Device for infusing liquids
DE3173564D1 (en) * 1980-09-02 1986-03-06 Medtronic Inc Subcutaneously implantable lead with drug dispenser means
US4552561A (en) * 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
EP0209644A1 (en) * 1985-05-02 1987-01-28 Ivac Corporation Electrochemically driven drug dispenser
FR2592306A1 (en) * 1985-12-30 1987-07-03 Couegnas Jacques Perfusion apparatus with adjustable flow rate causing no change in the perfused liquid
GB2191430A (en) * 1986-05-17 1987-12-16 David Sutcliffe Removing a label from an article by abrasive means
AT390004B (en) * 1986-09-05 1990-03-12 Schloegl Leopold Implantable device for metered administration of a substance, for example a medicament
ATE91239T1 (en) * 1987-05-18 1993-07-15 Disetronic Ag INFUSION DEVICE.
US5425706A (en) * 1989-02-24 1995-06-20 S. I. Scientific Innovations Ltd. Dispensing device particularly useful for dispensing nutritional liquids
US5062834A (en) * 1989-02-24 1991-11-05 Product Development (S.G.Z.) Ltd Device for dispensing a liquid particularly useful for delivering medicaments at a predetermined rate
FR2649617A1 (en) * 1989-07-12 1991-01-18 Veprol DEVICE FOR DELIVERING A PHARMACOLOGICAL ACTIVE PRINCIPLE BY ELECTROLYTIC PUMPING
IE80393B1 (en) * 1990-12-31 1998-06-17 Scient Innovations Ltd Liquid delivery device particularly useful for delivering drugs
DE69231073T2 (en) * 1991-10-24 2001-02-15 Insutech Inc INFUSION SYSTEM DRIVEN BY GAS PRESSURE GENERATED BY HYDROGEL BY ELECTROLYSIS
EP0984813A1 (en) * 1997-05-13 2000-03-15 Stuart D. Edwards Global medical treatment method and apparatus
ES2737835T3 (en) 2003-04-23 2020-01-16 Valeritas Inc Hydraulically driven pump for long-term medication administration
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US20080097291A1 (en) 2006-08-23 2008-04-24 Hanson Ian B Infusion pumps and methods and delivery devices and methods with same
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8512288B2 (en) 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
JP2009532117A (en) 2006-03-30 2009-09-10 ヴァレリタス,エルエルシー Multi-cartridge fluid dispensing device
US8597243B2 (en) 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
CA2685474C (en) 2007-04-30 2014-07-08 Medtronic Minimed, Inc. Reservoir filling, bubble management, and infusion medium delivery systems and methods with same
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
WO2010129583A1 (en) 2009-05-04 2010-11-11 Valeritas, Inc. Fluid transfer device
US8285328B2 (en) 2010-04-20 2012-10-09 Minipumps, Llc Remote-controlled drug pump devices
DK2455126T3 (en) 2010-11-15 2017-06-06 Hoffmann La Roche Container for storing medical or pharmaceutical fluids
US9199201B2 (en) 2011-12-15 2015-12-01 General Electric Company Self contained electroosmotic pump and method of making thereof
CN113348011B (en) * 2018-11-19 2023-04-18 比奥拉治疗股份有限公司 Method and apparatus for treating disease with biotherapeutic agents
US11587839B2 (en) 2019-06-27 2023-02-21 Analog Devices, Inc. Device with chemical reaction chamber
US11712516B2 (en) 2020-04-17 2023-08-01 Analog Devices, Inc. Fluid delivery device

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2913386A (en) * 1956-03-21 1959-11-17 Jr Leland C Clark Electrochemical device for chemical analysis
US3023750A (en) * 1959-03-04 1962-03-06 Howard C Baron Self-generating pressure device for infusion administration systems
US3050665A (en) * 1955-07-13 1962-08-21 Ray M Hurd Electrolytic product cell
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
US3518179A (en) * 1968-03-11 1970-06-30 Beckman Instruments Inc Temperature compensated electrochemical cell
US3604417A (en) * 1970-03-31 1971-09-14 Wayne Henry Linkenheimer Osmotic fluid reservoir for osmotically activated long-term continuous injector device
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US3732865A (en) * 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3760805A (en) * 1971-01-13 1973-09-25 Alza Corp Osmotic dispenser with collapsible supply container
US3760804A (en) * 1971-01-13 1973-09-25 Alza Corp Improved osmotic dispenser employing magnesium sulphate and magnesium chloride
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050665A (en) * 1955-07-13 1962-08-21 Ray M Hurd Electrolytic product cell
US2913386A (en) * 1956-03-21 1959-11-17 Jr Leland C Clark Electrochemical device for chemical analysis
US3023750A (en) * 1959-03-04 1962-03-06 Howard C Baron Self-generating pressure device for infusion administration systems
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
US3518179A (en) * 1968-03-11 1970-06-30 Beckman Instruments Inc Temperature compensated electrochemical cell
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US3604417A (en) * 1970-03-31 1971-09-14 Wayne Henry Linkenheimer Osmotic fluid reservoir for osmotically activated long-term continuous injector device
US3732865A (en) * 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3760805A (en) * 1971-01-13 1973-09-25 Alza Corp Osmotic dispenser with collapsible supply container
US3760804A (en) * 1971-01-13 1973-09-25 Alza Corp Improved osmotic dispenser employing magnesium sulphate and magnesium chloride
US3760984A (en) * 1971-09-29 1973-09-25 Alza Corp Osmotically powered agent dispensing device with filling means

Cited By (320)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4077405A (en) * 1975-03-26 1978-03-07 Siemens Aktiengesellschaft Apparatus for infusing liquids into human or animal bodies
US4217894A (en) * 1977-05-13 1980-08-19 Siemens Aktiengesellschaft Apparatus for supplying medication to the human or animal body
US4159720A (en) * 1977-11-28 1979-07-03 Burton Andrew F Infusion of liquids into tissue
US4559037A (en) * 1977-12-28 1985-12-17 Siemens Aktiengesellschaft Device for the pre-programmable infusion of liquids
US4205676A (en) * 1978-03-13 1980-06-03 Deley C. Humphrey Air pumping for medical uses
US4204538A (en) * 1978-06-07 1980-05-27 Imed Corporation Cassette for intravenous controller
US4265241A (en) * 1979-02-28 1981-05-05 Andros Incorporated Implantable infusion device
US4391600A (en) * 1979-03-09 1983-07-05 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4410322A (en) * 1979-03-09 1983-10-18 Avi, Inc. Nonpulsating TV pump and disposable pump chamber
US4382753A (en) * 1979-03-09 1983-05-10 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4573994A (en) * 1979-04-27 1986-03-04 The Johns Hopkins University Refillable medication infusion apparatus
DE3247232A1 (en) * 1979-04-27 1984-07-05 The Johns Hopkins University, Baltimore, Md. INFUSION SYSTEM FOR MEDICAL SUPPLY
US4941873A (en) * 1979-07-25 1990-07-17 Ultradent Products, Inc. Controlled diffusion medicament applicator
WO1983002063A1 (en) * 1981-12-07 1983-06-23 Univ Johns Hopkins Refillable medication infusion apparatus
EP0091621A1 (en) * 1982-04-05 1983-10-19 Milliken Research Corporation Low flow constant rate pump
DE3333977A1 (en) * 1982-09-20 1984-03-22 Infusaid Corp., Norwood, Mass. INFUSION PUMP
DE3390255C3 (en) * 1982-11-04 1998-08-20 Univ Johns Hopkins Infusion device
DE3390255C2 (en) * 1982-11-04 1992-06-25 Univ Johns Hopkins Implanted medication infusion appts. with pulsatile pump
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4596575A (en) * 1983-08-04 1986-06-24 Omikron Scientific Ltd. Liquid delivery system particularly useful as an implantable micropump for delivering insulin or other drugs
US4655765A (en) * 1984-06-01 1987-04-07 Parker Hannifin Corporation Fitting with prestressed septum
US4697622A (en) * 1984-06-01 1987-10-06 Parker Hannifin Corporation Passive filling device
WO1986003418A1 (en) * 1984-12-06 1986-06-19 Tran Loi H Therapeutic agent delivery system and method
AU590247B2 (en) * 1984-12-06 1989-11-02 Loi H. Tran Therapeutic agent delivery system and method
US4886514A (en) * 1985-05-02 1989-12-12 Ivac Corporation Electrochemically driven drug dispenser
EP0209677A1 (en) * 1985-06-07 1987-01-28 Ivac Corporation Electrochemically-driven pulsatile drug dispenser
US4687423A (en) * 1985-06-07 1987-08-18 Ivac Corporation Electrochemically-driven pulsatile drug dispenser
AU587877B2 (en) * 1985-11-22 1989-08-31 Industrikontakt Ing. O. Ellingsen & Co. An artificial gland for implantation in the human body
EP0259013A1 (en) * 1986-08-04 1988-03-09 Pharmetrix Corporation Portable controlled release osmotic infusion device
US4902278A (en) * 1987-02-18 1990-02-20 Ivac Corporation Fluid delivery micropump
US4857048A (en) * 1987-05-29 1989-08-15 Hewlett-Packard Company IV pump and disposable flow chamber with flow control
US4820273A (en) * 1988-03-01 1989-04-11 Eaton Corporation Implantable medication infusion device and bolus generator therefor
US20050013698A1 (en) * 1988-05-17 2005-01-20 Davis David Lyle Infusion device with disposable elements
US5584667A (en) * 1988-05-17 1996-12-17 Davis; David L. Method of providing uniform flow from an infusion device
US6146109A (en) * 1988-05-17 2000-11-14 Alaris Medical Systems, Inc. Infusion device with disposable elements
US6312227B1 (en) 1988-05-17 2001-11-06 I-Flow Corp. Infusion device with disposable elements
US6742992B2 (en) 1988-05-17 2004-06-01 I-Flow Corporation Infusion device with disposable elements
US5803712A (en) * 1988-05-17 1998-09-08 Patient Solutions, Inc. Method of measuring an occlusion in an infusion device with disposable elements
US20080015506A1 (en) * 1988-05-17 2008-01-17 Davis David L Infusion device with disposable elements
US4997371A (en) * 1988-06-22 1991-03-05 Honda Giken Kogyo Kabushiki Kaisha Dental agent applicator
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5242406A (en) * 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
US5090963A (en) * 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser
US5423454A (en) * 1992-08-19 1995-06-13 Lippman, Deceased; Lawrence G. Method of propellant gas generation
US5246371A (en) * 1992-08-31 1993-09-21 Ultradent Products, Inc. Method and apparatus for delivery of highly filled, thixotropic sealant to teeth
US5269684A (en) * 1992-08-31 1993-12-14 Ultradent Products, Inc. Adjustable brush delivery tip with secondary flow path
US5397303A (en) * 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
US5571261A (en) * 1993-08-06 1996-11-05 River Medical, Inc Liquid delivery device
US5558255A (en) * 1993-08-06 1996-09-24 River Medical, Inc. Liquid delivery device
US5553741A (en) * 1993-08-06 1996-09-10 River Medical, Inc. Liquid delivery device
US5578005A (en) * 1993-08-06 1996-11-26 River Medical, Inc. Apparatus and methods for multiple fluid infusion
US5398851A (en) * 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5925030A (en) * 1994-08-15 1999-07-20 Elan Corporation, Plc Orally administrable delivery device
US5836935A (en) * 1994-11-10 1998-11-17 Ashton; Paul Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
US5997821A (en) * 1995-06-07 1999-12-07 Ceramatec Corporation Gas amplifier
US5855761A (en) * 1995-06-07 1999-01-05 Ceramatec, Inc. Gas amplifier
US5766147A (en) * 1995-06-07 1998-06-16 Winfield Medical Vial adaptor for a liquid delivery device
WO1996041159A1 (en) * 1995-06-07 1996-12-19 Ceramatec, Inc. Gas amplifier
US6060196A (en) * 1995-10-06 2000-05-09 Ceramtec, Inc. Storage-stable zinc anode based electrochemical cell
US6042704A (en) * 1995-10-06 2000-03-28 Ceramatec, Inc. Storage-stable, fluid dispensing device using a hydrogen gas generator
WO1997013007A1 (en) 1995-10-06 1997-04-10 Ceramatec, Inc. Storage-stable, fluid dispensing device using a hydrogen gas generator
US5707499A (en) * 1995-10-06 1998-01-13 Ceramatec, Inc. Storage-stable, fluid dispensing device using a hydrogen gas generator
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
US5964261A (en) * 1996-05-29 1999-10-12 Baxter International Inc. Implantation assembly
US5939032A (en) * 1996-06-20 1999-08-17 Samsung Electronics Co., Ltd. Apparatus and method for on-line decomposition of hydrogen peroxide solution in fabrication of semiconductor device
US6146898A (en) * 1996-06-20 2000-11-14 Samsung Electronics Co., Ltd. Apparatus and method for on-line decomposition of hydrogen peroxide solution in fabrication of semiconductor device
WO1999006614A1 (en) 1996-07-23 1999-02-11 Microlin, L.C. Storage stable electrolytic gas generator for fluid dispensing applications
US5899381A (en) * 1997-02-21 1999-05-04 Ceramatec, Inc. Electrochemical device for delivery of volatile substances
US5938640A (en) * 1997-06-04 1999-08-17 M&R Consulting Services Two-part fluid dispenser
WO2000074751A1 (en) * 1999-06-08 2000-12-14 Medical Research Group, Inc. Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device
US6520936B1 (en) 1999-06-08 2003-02-18 Medtronic Minimed, Inc. Method and apparatus for infusing liquids using a chemical reaction in an implanted infusion device
US9981083B2 (en) 2000-11-30 2018-05-29 Valeritas, Inc. Fluid delivery and measurement systems and methods
US7481792B2 (en) 2000-11-30 2009-01-27 Valeritas, Inc. Fluid delivery and measurement systems and methods
US9636451B2 (en) 2000-11-30 2017-05-02 Valeritas, Inc. Fluid delivery and measurement systems and methods
US10610640B2 (en) 2000-11-30 2020-04-07 Valeritas, Inc. Fluid delivery and measurement systems and methods
US8858511B2 (en) 2000-11-30 2014-10-14 Valeritas, Inc. Fluid delivery and measurement systems and methods
US20060189939A1 (en) * 2000-11-30 2006-08-24 Biovalve Technologies, Inc. Fluid delivery and measurement systems and methods
US8992478B2 (en) 2000-11-30 2015-03-31 Valeritas, Inc. Fluid delivery and measurement systems and methods
US20090093763A1 (en) * 2000-11-30 2009-04-09 Gonnelli Robert R Fluid delivery and measurement systems and methods
US8740929B2 (en) 2001-02-06 2014-06-03 Acclarent, Inc. Spacing device for releasing active substances in the paranasal sinus
US20080243140A1 (en) * 2001-02-06 2008-10-02 Acclarent, Inc. Spacing devices for releasing active substances in the paranasal sinus
US6701724B2 (en) 2001-06-06 2004-03-09 Nanopore, Inc. Sorption cooling devices
WO2002099345A1 (en) * 2001-06-06 2002-12-12 Nanopore, Inc. Sorption cooling devices and temperature-controlled shipping containers incorporating sorption cooling devices
US6968711B2 (en) 2001-06-06 2005-11-29 Nanopore, Inc. Temperature controlled shipping containers
US20040231346A1 (en) * 2001-06-06 2004-11-25 Smith Douglas M. Sorption cooling devices
US20060064052A1 (en) * 2001-08-31 2006-03-23 Agency For Science, Technology & Research Liquid delivering device
WO2003018089A1 (en) * 2001-08-31 2003-03-06 Institute Of Materials Research And Engineering Liquid delivering device
CN100356993C (en) * 2001-08-31 2007-12-26 新加坡科技研究局 Liquid delivering device
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20030083619A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Microneedle transdermal transport device
US20030083641A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Impedance sensor
US20080319392A1 (en) * 2001-10-26 2008-12-25 Angel Aimee B Microneedle transport device
US7651475B2 (en) 2001-10-26 2010-01-26 Massachusetts Institute Of Technology Microneedle transport device
US20080281273A1 (en) * 2001-10-26 2008-11-13 Massachusetts Institute Of Technology Microneedle transdermal transport device
US20030083618A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Transdermal transport device with an electrolytic actuator
US7364568B2 (en) 2001-10-26 2008-04-29 Massachusetts Institute Of Technology Microneedle transdermal transport device
US8246582B2 (en) 2001-10-26 2012-08-21 Massachusetts Institute Of Technology Microneedle transdermal transport device
US7645263B2 (en) 2001-10-26 2010-01-12 Massachusetts Institute Of Technology Impedance sensor
US6787008B2 (en) 2001-10-30 2004-09-07 Microlin, L.C. Hydrogen generating cell with cathode
US20030082415A1 (en) * 2001-10-30 2003-05-01 Joshi Ashok V. Hydrogen generating cell with cathode
WO2003072941A2 (en) * 2002-02-28 2003-09-04 Universite Joseph Fourier Osmotic actuator and engine
FR2836520A1 (en) * 2002-02-28 2003-08-29 Univ Joseph Fourier Osmotic actuator
WO2003072941A3 (en) * 2002-02-28 2004-03-04 Univ Joseph Fourier Osmotic actuator and engine
US20050158841A1 (en) * 2002-02-28 2005-07-21 Philippe Cinquin Osmotic actuator and engine
US7544508B2 (en) 2002-02-28 2009-06-09 Universite Joseph Fourier Osmotic actuator and engine
US20030205582A1 (en) * 2002-05-01 2003-11-06 Joshi Ashok V. Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method
US20060052768A1 (en) * 2002-05-01 2006-03-09 Microlin, L.C. Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US7470267B2 (en) 2002-05-01 2008-12-30 Microlin, Llc Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method
US7458965B2 (en) 2002-05-01 2008-12-02 Microlin, Llc Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US20060116663A1 (en) * 2002-05-01 2006-06-01 Joshi Ashok V Electro-osmotic fluid delivery device and method
US20060116641A1 (en) * 2002-05-01 2006-06-01 Microlin, L.C. Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US7896867B2 (en) 2002-05-01 2011-03-01 Microlin, Llc Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US20040007456A1 (en) * 2002-07-15 2004-01-15 Holstun Clayton L. Generation of gas in a lab-on-a-chip environment
EP1403400A1 (en) * 2002-07-15 2004-03-31 Hewlett-Packard Development Company, L.P. Generation of gas in a lab-on-a-chip environment
US6814852B2 (en) 2002-07-15 2004-11-09 Hewlett-Packard Development Company, L.P. Generation of gas in a lab-on-a-chip environment
US7341581B2 (en) 2002-07-19 2008-03-11 Phluid, Inc. Infusion pump and method for use
US7374556B2 (en) 2002-07-19 2008-05-20 Tandem Diabetes Care Infusion pump and method for use
US7008403B1 (en) 2002-07-19 2006-03-07 Cognitive Ventures Corporation Infusion pump and method for use
US20060150748A1 (en) * 2002-07-19 2006-07-13 Phlvid, Inc. Infusion pump and method for use
US20060150747A1 (en) * 2002-07-19 2006-07-13 Phluid, Inc. Infusion pump and method for use
US6793462B2 (en) * 2002-07-25 2004-09-21 Motorola, Inc. Fluidic pump
US20040018095A1 (en) * 2002-07-25 2004-01-29 Smekal Thomas J. Fluidic pump
US8100933B2 (en) 2002-09-30 2012-01-24 Acclarent, Inc. Method for treating obstructed paranasal frontal sinuses
US8764786B2 (en) 2002-09-30 2014-07-01 Acclarent, Inc. Balloon catheters and methods for treating paranasal sinuses
US8317816B2 (en) 2002-09-30 2012-11-27 Acclarent, Inc. Balloon catheters and methods for treating paranasal sinuses
US9457175B2 (en) 2002-09-30 2016-10-04 Acclarent, Inc. Balloon catheters and methods for treating paranasal sinuses
US20040230183A1 (en) * 2003-02-18 2004-11-18 Wisam Breegi Drug delivery device and syringe for filling the same
US20050038415A1 (en) * 2003-08-06 2005-02-17 Rohr William L. Method and apparatus for the treatment of obesity
US8142422B2 (en) 2004-04-21 2012-03-27 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US10098652B2 (en) 2004-04-21 2018-10-16 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US11864725B2 (en) 2004-04-21 2024-01-09 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US11589742B2 (en) 2004-04-21 2023-02-28 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US11529502B2 (en) 2004-04-21 2022-12-20 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US11511090B2 (en) 2004-04-21 2022-11-29 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US11202644B2 (en) 2004-04-21 2021-12-21 Acclarent, Inc. Shapeable guide catheters and related methods
US11065061B2 (en) 2004-04-21 2021-07-20 Acclarent, Inc. Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US11020136B2 (en) 2004-04-21 2021-06-01 Acclarent, Inc. Deflectable guide catheters and related methods
US11019989B2 (en) 2004-04-21 2021-06-01 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US10874838B2 (en) 2004-04-21 2020-12-29 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US10856727B2 (en) 2004-04-21 2020-12-08 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US10806477B2 (en) 2004-04-21 2020-10-20 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US10779752B2 (en) 2004-04-21 2020-09-22 Acclarent, Inc. Guidewires for performing image guided procedures
US10702295B2 (en) 2004-04-21 2020-07-07 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US10695080B2 (en) 2004-04-21 2020-06-30 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US10631756B2 (en) 2004-04-21 2020-04-28 Acclarent, Inc. Guidewires for performing image guided procedures
US10500380B2 (en) 2004-04-21 2019-12-10 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US20110112512A1 (en) * 2004-04-21 2011-05-12 Acclarent, Inc. Devices and methods for treating maxillary sinus disease
US10492810B2 (en) 2004-04-21 2019-12-03 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US10441758B2 (en) 2004-04-21 2019-10-15 Acclarent, Inc. Frontal sinus spacer
US10188413B1 (en) 2004-04-21 2019-01-29 Acclarent, Inc. Deflectable guide catheters and related methods
US10034682B2 (en) 2004-04-21 2018-07-31 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US9826999B2 (en) 2004-04-21 2017-11-28 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US8080000B2 (en) 2004-04-21 2011-12-20 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US8088101B2 (en) 2004-04-21 2012-01-03 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8090433B2 (en) 2004-04-21 2012-01-03 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US9649477B2 (en) 2004-04-21 2017-05-16 Acclarent, Inc. Frontal sinus spacer
US9610428B2 (en) 2004-04-21 2017-04-04 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US8114062B2 (en) 2004-04-21 2012-02-14 Acclarent, Inc. Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders
US9554691B2 (en) 2004-04-21 2017-01-31 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8123722B2 (en) 2004-04-21 2012-02-28 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US9468362B2 (en) 2004-04-21 2016-10-18 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8146400B2 (en) 2004-04-21 2012-04-03 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8172828B2 (en) 2004-04-21 2012-05-08 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US9399121B2 (en) 2004-04-21 2016-07-26 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US9370649B2 (en) 2004-04-21 2016-06-21 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US9351750B2 (en) 2004-04-21 2016-05-31 Acclarent, Inc. Devices and methods for treating maxillary sinus disease
US9265407B2 (en) 2004-04-21 2016-02-23 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9241834B2 (en) 2004-04-21 2016-01-26 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US9220879B2 (en) 2004-04-21 2015-12-29 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US9167961B2 (en) 2004-04-21 2015-10-27 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US9107574B2 (en) 2004-04-21 2015-08-18 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9101384B2 (en) 2004-04-21 2015-08-11 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat
US9089258B2 (en) 2004-04-21 2015-07-28 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9055965B2 (en) 2004-04-21 2015-06-16 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US8961398B2 (en) 2004-04-21 2015-02-24 Acclarent, Inc. Methods and apparatus for treating disorders of the ear, nose and throat
US8961495B2 (en) 2004-04-21 2015-02-24 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8414473B2 (en) 2004-04-21 2013-04-09 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US8425457B2 (en) 2004-04-21 2013-04-23 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorder of the ears, nose and/or throat
US8945088B2 (en) 2004-04-21 2015-02-03 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US8932276B1 (en) 2004-04-21 2015-01-13 Acclarent, Inc. Shapeable guide catheters and related methods
US8905922B2 (en) 2004-04-21 2014-12-09 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US8894614B2 (en) 2004-04-21 2014-11-25 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US8870893B2 (en) 2004-04-21 2014-10-28 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US8702626B1 (en) 2004-04-21 2014-04-22 Acclarent, Inc. Guidewires for performing image guided procedures
US8715169B2 (en) 2004-04-21 2014-05-06 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US8721591B2 (en) 2004-04-21 2014-05-13 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US8864787B2 (en) 2004-04-21 2014-10-21 Acclarent, Inc. Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis
US8747389B2 (en) 2004-04-21 2014-06-10 Acclarent, Inc. Systems for treating disorders of the ear, nose and throat
US8858586B2 (en) 2004-04-21 2014-10-14 Acclarent, Inc. Methods for enlarging ostia of paranasal sinuses
US8852143B2 (en) 2004-04-21 2014-10-07 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8764726B2 (en) 2004-04-21 2014-07-01 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US8764709B2 (en) 2004-04-21 2014-07-01 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8764729B2 (en) 2004-04-21 2014-07-01 Acclarent, Inc. Frontal sinus spacer
US8777926B2 (en) 2004-04-21 2014-07-15 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasel or paranasal structures
US8828041B2 (en) 2004-04-21 2014-09-09 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US9039680B2 (en) 2004-08-04 2015-05-26 Acclarent, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
EP2263738A3 (en) * 2004-08-04 2011-11-09 Acclarent, Inc. Implantable devices for delivering drugs and other substances to treat sinusitis and other disorders
US9039657B2 (en) 2004-08-04 2015-05-26 Acclarent, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US9084876B2 (en) 2004-08-04 2015-07-21 Acclarent, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
EP1778335A2 (en) * 2004-08-04 2007-05-02 ExploraMed NC1, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
EP1778335A4 (en) * 2004-08-04 2008-07-09 Exploramed Nc1 Inc Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
EP2845621A3 (en) * 2004-08-04 2015-04-08 Acclarent, Inc. Implantable devices for delivering drugs and other substances to treat sinusitis and other disorders
US7718047B2 (en) 2004-10-19 2010-05-18 The Regents Of The University Of Colorado Electrochemical high pressure pump
US20060207883A1 (en) * 2004-10-19 2006-09-21 Koval Carl A Electrochemical high pressure pump
US9308361B2 (en) 2005-01-18 2016-04-12 Acclarent, Inc. Implantable devices and methods for treating sinusitis and other disorders
US8388642B2 (en) 2005-01-18 2013-03-05 Acclarent, Inc. Implantable devices and methods for treating sinusitis and other disorders
US20060264897A1 (en) * 2005-01-24 2006-11-23 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
WO2006082345A1 (en) * 2005-02-03 2006-08-10 Universite Joseph Fourier Chemical activation of an actuator or an osmotic motor
FR2881481A1 (en) * 2005-02-03 2006-08-04 Univ Grenoble 1 Osmotic actuator to palliate the deficiency of heart muscle, respiratory muscles and sphincters, comprises an enclosure with wall which is non-permeable to a solute and permeable to a solvent, and a deformable chamber
US20090120082A1 (en) * 2005-02-03 2009-05-14 Francois Lenouvel Chemical Activation of an Actuator or an Osmotic Motor
US8859269B2 (en) 2005-02-03 2014-10-14 Universite Joseph Fourier Chemical activation of an actuator or an osmotic motor
US20110077579A1 (en) * 2005-03-24 2011-03-31 Harrison William V Cochlear implant with localized fluid transport
US20110125136A1 (en) * 2005-06-08 2011-05-26 Morteza Gharib Intravascular diagnostic and therapeutic sampling device
US20060280655A1 (en) * 2005-06-08 2006-12-14 California Institute Of Technology Intravascular diagnostic and therapeutic sampling device
US10124154B2 (en) 2005-06-10 2018-11-13 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US10842978B2 (en) 2005-06-10 2020-11-24 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US20100222770A1 (en) * 2005-07-01 2010-09-02 John Howard Gordon Fluid delivery device with a diffusion membrane for fast response time
US8348930B2 (en) 2005-07-01 2013-01-08 Microlin, Llc Fluid delivery device with a diffusion membrane and electrochemical pump
US20070021734A1 (en) * 2005-07-15 2007-01-25 Sai Bhavaraju Bioelectro-osmotic engine fluid delivery device
US8968269B2 (en) 2005-09-23 2015-03-03 Acclarent, Inc. Multi-conduit balloon catheter
US9999752B2 (en) 2005-09-23 2018-06-19 Acclarent, Inc. Multi-conduit balloon catheter
US9050440B2 (en) 2005-09-23 2015-06-09 Acclarent, Inc. Multi-conduit balloon catheter
US8114113B2 (en) 2005-09-23 2012-02-14 Acclarent, Inc. Multi-conduit balloon catheter
US10639457B2 (en) 2005-09-23 2020-05-05 Acclarent, Inc. Multi-conduit balloon catheter
US9693894B2 (en) 2006-03-14 2017-07-04 The University Of Southern California MEMS device and method for delivery of therapeutic agents
US20090198220A1 (en) * 2006-04-28 2009-08-06 Michel Paul Barbara Van Bruggen Osmotic pump with at least one chargeable material
WO2007125456A3 (en) * 2006-04-28 2008-12-31 Koninkl Philips Electronics Nv Micropump with at least one gas releasing material
WO2007125456A2 (en) * 2006-04-28 2007-11-08 Koninklijke Philips Electronics N. V. Micropump with at least one gas releasing material
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US8190389B2 (en) 2006-05-17 2012-05-29 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US9198736B2 (en) 2006-05-17 2015-12-01 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US9629656B2 (en) 2006-05-17 2017-04-25 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US20070287984A1 (en) * 2006-06-09 2007-12-13 Neurosystec Corporation Flow-Induced Delivery from a Drug Mass
US20110071493A1 (en) * 2006-06-09 2011-03-24 Neurosystec Corporation Flow-Induced Delivery from a Drug Mass
US7803148B2 (en) 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
US8298176B2 (en) 2006-06-09 2012-10-30 Neurosystec Corporation Flow-induced delivery from a drug mass
US20080152694A1 (en) * 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
US20080065002A1 (en) * 2006-09-07 2008-03-13 Neurosystec Corporation Catheter for Localized Drug Delivery and/or Electrical Stimulation
US9603506B2 (en) 2006-09-15 2017-03-28 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US9572480B2 (en) 2006-09-15 2017-02-21 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US9820688B2 (en) 2006-09-15 2017-11-21 Acclarent, Inc. Sinus illumination lightwire device
US9179823B2 (en) 2006-09-15 2015-11-10 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US10716629B2 (en) 2006-09-15 2020-07-21 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US20110184389A1 (en) * 2006-11-01 2011-07-28 Medtronic, Inc. Osmotic pump apparatus and associated methods
US20080147007A1 (en) * 2006-12-19 2008-06-19 Toby Freyman Delivery device with pressure control
US8439687B1 (en) 2006-12-29 2013-05-14 Acclarent, Inc. Apparatus and method for simulated insertion and positioning of guidewares and other interventional devices
US9615775B2 (en) 2007-04-30 2017-04-11 Acclarent, Inc. Methods and devices for ostium measurements
US8118757B2 (en) 2007-04-30 2012-02-21 Acclarent, Inc. Methods and devices for ostium measurement
US8485199B2 (en) 2007-05-08 2013-07-16 Acclarent, Inc. Methods and devices for protecting nasal turbinate during surgery
US9463068B2 (en) 2007-05-08 2016-10-11 Acclarent, Inc. Methods and devices for protecting nasal turbinates
US11311419B2 (en) 2007-12-20 2022-04-26 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US9271866B2 (en) 2007-12-20 2016-03-01 University Of Southern California Apparatus and methods for delivering therapeutic agents
US20090240215A1 (en) * 2007-12-20 2009-09-24 Mark Humayun Apparatus and methods for delivering therapeutic agents
US11850120B2 (en) 2007-12-20 2023-12-26 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US9308124B2 (en) 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
US10206821B2 (en) 2007-12-20 2019-02-19 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US10117774B2 (en) 2007-12-20 2018-11-06 University Of Southern California Apparatus and methods for delivering therapeutic agents
US20090209945A1 (en) * 2008-01-18 2009-08-20 Neurosystec Corporation Valveless impedance pump drug delivery systems
US20090191067A1 (en) * 2008-01-25 2009-07-30 Phluid,Inc. Two chamber pumps and related methods
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US9861793B2 (en) 2008-03-10 2018-01-09 Acclarent, Inc. Corewire design and construction for medical devices
US8182432B2 (en) 2008-03-10 2012-05-22 Acclarent, Inc. Corewire design and construction for medical devices
US9861525B2 (en) 2008-05-08 2018-01-09 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US8231608B2 (en) * 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US20090306585A1 (en) * 2008-05-08 2009-12-10 Changlin Pang Implantable pumps and cannulas therefor
US9623174B2 (en) 2008-05-08 2017-04-18 Minipumps, Llc Implantable pumps and cannulas therefor
US9283322B2 (en) 2008-05-08 2016-03-15 Minipumps, Llc Drug-delivery pump with dynamic, adaptive control
US20090312742A1 (en) * 2008-05-08 2009-12-17 Changlin Pang Drug-delivery pumps and methods of manufacture
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
US8231609B2 (en) * 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US20090306594A1 (en) * 2008-05-08 2009-12-10 Changlin Pang Drug-delivery pumps and methods of manufacture
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
US20110202032A1 (en) * 2008-05-08 2011-08-18 Jason Shih Drug-delivery pumps with dynamic, adaptive control
US9162024B2 (en) 2008-05-08 2015-10-20 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US20100004639A1 (en) * 2008-05-08 2010-01-07 Changlin Pang Drug-delivery pumps and methods of manufacture
US9107995B2 (en) 2008-05-08 2015-08-18 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US9199035B2 (en) 2008-05-08 2015-12-01 Minipumps, Llc. Drug-delivery pumps with dynamic, adaptive control
US8979888B2 (en) 2008-07-30 2015-03-17 Acclarent, Inc. Paranasal ostium finder devices and methods
US10271719B2 (en) 2008-07-30 2019-04-30 Acclarent, Inc. Paranasal ostium finder devices and methods
US9750401B2 (en) 2008-07-30 2017-09-05 Acclarent, Inc. Paranasal ostium finder devices and methods
US11116392B2 (en) 2008-07-30 2021-09-14 Acclarent, Inc. Paranasal ostium finder devices and methods
US8056582B2 (en) 2008-08-08 2011-11-15 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
US20100032041A1 (en) * 2008-08-08 2010-02-11 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8448824B2 (en) 2008-09-16 2013-05-28 Tandem Diabetes Care, Inc. Slideable flow metering devices and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US10524814B2 (en) 2009-03-20 2020-01-07 Acclarent, Inc. Guide system with suction
US11207087B2 (en) 2009-03-20 2021-12-28 Acclarent, Inc. Guide system with suction
US10376416B2 (en) 2009-03-31 2019-08-13 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US9072626B2 (en) 2009-03-31 2015-07-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US9636258B2 (en) 2009-03-31 2017-05-02 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US8435290B2 (en) 2009-03-31 2013-05-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US8926561B2 (en) 2009-07-30 2015-01-06 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9211377B2 (en) 2009-07-30 2015-12-15 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8287495B2 (en) 2009-07-30 2012-10-16 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8298184B2 (en) 2009-07-30 2012-10-30 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8758323B2 (en) 2009-07-30 2014-06-24 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US11285263B2 (en) 2009-07-30 2022-03-29 Tandem Diabetes Care, Inc. Infusion pump systems and methods
US11135362B2 (en) 2009-07-30 2021-10-05 Tandem Diabetes Care, Inc. Infusion pump systems and methods
US9155492B2 (en) 2010-09-24 2015-10-13 Acclarent, Inc. Sinus illumination lightwire device
US10258736B2 (en) 2012-05-17 2019-04-16 Tandem Diabetes Care, Inc. Systems including vial adapter for fluid transfer
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9433437B2 (en) 2013-03-15 2016-09-06 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9629684B2 (en) 2013-03-15 2017-04-25 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US10524869B2 (en) 2013-03-15 2020-01-07 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US20200129692A1 (en) * 2016-09-08 2020-04-30 Eoflow Co., Ltd. Liquid medicine injection device
US11738137B2 (en) * 2016-09-08 2023-08-29 Eoflow Co., Ltd. Liquid medicine injection device
US10549030B2 (en) * 2016-09-08 2020-02-04 Eoflow Co., Ltd. Liquid medicine injection device
US11607490B2 (en) 2016-11-01 2023-03-21 Sanofi-Aventis Deutschland Gmbh Volume measuring arrangement
CN109890434A (en) * 2016-11-01 2019-06-14 赛诺菲-安万特德国有限公司 Cubing component
US9849233B1 (en) * 2017-05-10 2017-12-26 Novus Medical Products, Inc. Disposable infusion pump system for ambulatory patients
US11097871B2 (en) * 2017-05-31 2021-08-24 Yoshino Kogyosho Co., Ltd. Synthetic resin container
US11717636B2 (en) * 2019-10-01 2023-08-08 GE Precision Healthcare LLC Anesthesia vaporizer system having a variable volume reservoir
US20210093826A1 (en) * 2019-10-01 2021-04-01 GE Precision Healthcare LLC Anesthesia Vaporizer System Having a Variable Volume Reservoir
WO2022046906A1 (en) * 2020-08-27 2022-03-03 Analog Devices, Inc. Fluid delivery system
US11604084B2 (en) 2021-04-15 2023-03-14 Analog Devices, Inc. Sensor package
US11796367B2 (en) 2021-05-07 2023-10-24 Analog Devices, Inc. Fluid control system

Also Published As

Publication number Publication date
DE2239432B2 (en) 1976-08-26
FR2195461B1 (en) 1977-07-29
FR2195461A1 (en) 1974-03-08
ATA670673A (en) 1978-01-15
CH557178A (en) 1974-12-31
GB1452138A (en) 1976-10-13
SE419406B (en) 1981-08-03
NL7310455A (en) 1974-02-12
AT345438B (en) 1978-09-11
GB1452104A (en) 1976-10-13
DE2239432A1 (en) 1974-02-21

Similar Documents

Publication Publication Date Title
US3894538A (en) Device for supplying medicines
US4140121A (en) Implantable dosing device
US4140122A (en) Implantable dosing device
US7896867B2 (en) Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US8348930B2 (en) Fluid delivery device with a diffusion membrane and electrochemical pump
US7458965B2 (en) Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
US3837339A (en) Blood glucose level monitoring-alarm system and method therefor
US4639244A (en) Implantable electrophoretic pump for ionic drugs and associated methods
US5354264A (en) Gas pressure driven infusion system by hydrogel electrolysis
US4902278A (en) Fluid delivery micropump
GB1602158A (en) Device for supplying a medicinal liquid to a human or animal body
AU2002309905B2 (en) Fluid delivery device having a water generating electrochemical/chemical pump and associated method
US4853091A (en) Method and apparatus for the electrochemical determination of oxygen concentration
US20060116663A1 (en) Electro-osmotic fluid delivery device and method
JP2006516444A (en) Drug infusion device
WO1999043383A1 (en) Sensor controlled analysis and therapeutic delivery system
US7371229B2 (en) Dual electrode advanced electrochemical delivery system
US5611779A (en) Electrochemical fluid delivery device
KR20170122582A (en) Tubeless implantable drug infusion system
WO2007005565A2 (en) Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
EP1904035A2 (en) Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method
DE2239432C3 (en) Device for the delivery of medication
DE7229713U (en) DEVICE FOR DISPENSING DRUGS
Luft et al. Electro-osmotic valve for the controlled administration of drugs
CA1265964A (en) Implantable electrophoretic pump for ionic drugs and associated methods