|Publication number||US3875300 A|
|Publication date||1 Apr 1975|
|Filing date||18 Dec 1972|
|Priority date||18 Dec 1972|
|Also published as||DE2362991A1|
|Publication number||US 3875300 A, US 3875300A, US-A-3875300, US3875300 A, US3875300A|
|Inventors||Homm Roger, Katz Gilbert|
|Original Assignee||Ortho Pharma Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (2), Referenced by (87), Classifications (13)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Homm et al.
Apr. 1, 1975 COMPOSITIN FOR SUSTAINED RELEASE OF A MEDICAMENT AND METHOD OF USING SAME Inventors: Roger Homm, Neshanic; Gilbert Katz, Boonton, both of NJ.
Ortho Pharmaceutical Corporation, Rariton, NJ.
Filed: Dec. 18, 1972 Appl. No.: 316,175
us. c1 ..424/28, 424/27, 128/260, 128/270, 128/271, 128/285 1111. c1 A611 19/00 Field 01 Search 424/27, 28; 128/260, 270, 128/271, 285
References Cited UNlTED STATES PATENTS 12/1962 Morton ct a1 1. 424/28 3,108,043 10/1963 Millman et a1 424/27 X FOREIGN PATENTS OR APPLICATIONS 263,153 3/1960 Australia 722,629 l/1955 United Kingdom 735,370 8/1955 United Kingdom Primary E.\'aminerShep K. Rose Attorney, Agent, or Firm-Benjamin F. Lambert  ABSTRACT A solid, intimately admixed compostion comprising a thermoplastic, physiologically-inert polymer soluble in body fluids, andan effective amount of a suitable medicament. The composition is suitable for introduction into a body cavity, therein to be slowly dissolved by body fluids and release thereby incremental amounts of medicament. Various areas of use include intravaginal applications for spermicidal effect, subcutaneous implantation, and the, like.
14 Claims, N0 Drawings COMPOSITIN FOR SUSTAINED RELEASE OF A MEDICAMENT AND METHOD OF USING SAME BACKGROUND OF THE INVENTION The present invention relates to an improved medicament dispensing system of special use in contraception. More particularly it relates to a composition of matter useful for delivering controlled amounts of a medicament within a body cavity at a pre-determined rate.
Delivery of medicaments to a site within a body cavity is usually accomplished either systemically by oral administration or locally by direct introduction into the cavity. The systemic method has the advantage of being convenient, but because it is systemic suffers from side effect" problems. Direct introduction has the advantage of requiring lower doses and is faster acting, but is also usually very inconvenient and quite often unpredictable in efficacy. In this method, the concentration of medicament in the body cavity is not maintained at a constant level, but is rather at a maximum just after application and declines thereafter. Thus, in order to have an effective amount of medicament in the body cavity at all times, it is necessary when using the direct introduction method to give either a moderate excess at short intervals or a large excess at longer intervals. Neither of these alternatives is satisfactorily convenient or economical.
One of the areas of major interest as regards direct introduction of medicaments into body cavities is contraception. Several contraceptive methods are currently employed. For example, there are those which prevent ovulation, those which prevent implantation, and those which prevent sperm from coming in contact with a released ovum. The first method is typified by oral administration of various drugs, usually steroids, and has the disadvantage of being systemic rather than topical. It is advantageous, however, in that administration immediately prior to coitus is not necessary.
The second method is typified by insertion into the uterus and maintenance therein of a foreign object called an intrauterine device. This method has the advantage of the first method and is also topical, but is disadvantageous because of the undesirably high possibility of perforating the uterus. Moreover, the devices are usually painful during the insertion process and usually for long periods thereafter during residency.
A third method usually involves placing some physical or chemical barrier between the sperm and the ovum and is typified by a condom, a spermicidal foam or jelly, and the like, or a combination of two or more of these. This third type has the disadvantage of requiring application just prior to coitus, but has the advantages of being topical in application and having no extravaginal effects. This method would be very desirable indeed if application of the material were required not immediately before coitus but rather at some prior time much in advance of coitus.
The present invention provides a system and method especially suited for contraceptive use of the third type, but capable of broader applications which does not have the disadvantages traditionally associated with it. That is, the invention provides a solid drug delivery system of the type which is inserted into the vagina up to 24 hours prior to coitus and slowly releases a spermicide. The system does not require removal or storage after use since it is soluble in body fluids and is diffused by the system. The present invention, therefore, in its broader aspects provides a solid drug delivery system comprising in intimate admixture a body fluid-soluble, thermoplastic, physiologically-inert polymer and an effective amount ofa suitable medicament. The term medicament includes but is not limited to spermicides, ovacides, antimicrobials, anti-inflammatories, steroidal and non-steroidal anti-fertility agents, prostaglandins, and the like, and includes any compound, drug or medicine having a desired physiological effect.
The polymer may be any of those which are soluble in body fluids such as, for example, a cellulose, a starch, an alginate, a polyvinyl alcohol, a polyvinyl pyrrolidone, a polyacrylamide, an ethyleneoxide polymer, or the like. Preferably, the solubility characteristics of the polymer are chosen so that the entire mass is totally dissolved in the body cavity fluids within a period of about 24 hours so as to give a sustained, prolonged release of medicament. Where vaginal use is contemplated, the preferred polymer is a hydroxypropyl cellulose or hydroxypropylmethyl cellulose having a molecular weight of from 60,000 to 1,000,000. Typically employable here are cellulose ethers having a high degree of ideal propyl substitution at the hydroxyl groups. From to I00 percent propyl substitution is suitable. The product of the invention may be provided in the form of fibers, molded articles or extruded shapes, in which form they may then be placed in the body cavity where they will dissolve and release the medicament at a desirable rate.
The composition of the present invention will contain various amounts of polymer and medicament relative to one another depending upon many factors including the final use to which the composition will be put, the nature of the drug employed, the actual solubility characteristics of the polymer, and the like. In general, however, a composition containing up to about 30 weight percent of the medicament with the balance being essentially polymer will be suitable. Preferably, however, the amount of medicament ranges from 5 to 25 percent by weight based on the weight of the entire composition. Such a formulation is especially suitable for contraceptive use when the composition comprises a spermicide as the medicament and hydroxypropyl cellulose as the polymer.
The compositions of the present invention are prepared by intimately blending the desired polymer in any convenient form such as pellet or powder form with the appropriate amount of medicament. This intimate mixture is then spun, cast, molded, or extruded into fibers or suitable shapes, either with or without the addition of solvents or additional plasticizers.
For example, using hydroxypropyl cellulose as illustrative, a typical preparation is as follows: Hydroxypropyl cellulose powder is intimately mixed with a suitable amount of a medicament, preferably a spermicide. The resulting mixture is melt spun using standard spinning techniques into a strand and the strand chopped into pellets. These pellets are then charged into a standard melt spinning apparatus, are spun into fine fibers and the fibers chopped into lengths convenient for subsequently forming cotton' balls from the fibers. Dry carding techniques are then employed to form cotton balls or wads. There results from this operation the preferred form of the composition of the invention when an intravaginal contraceptive system is sought. The pellets may, on the other hand, be used in the molding or extrusion of a suitable shape, e.g., a circular film, a diaphragm, or the like.
The techniques of fiber formation may vary depending on the particular polymer being used, but these techniques are all within the skill of the art and basically form no part of the present invention. For example, when polyvinyl alcohol is used as the polymer, wet spinning techniques, using an aqueous solution of a suitable coagulating agent, e.g.,'Na SO,, (NH SO MgSO or the like may be employed. Standard wet spinning techniques are also employed when using hydroxypropylmethyl cellulose.
As stated, the preferred composition of the present invention is a mixture of hydroxypropyl cellulose with a spermicide, preferably in the form of a fibrous mass. The spermicide may be any compound known to be spermicidal and compatible with the polymeric system used. Typically acceptable are non-ionic surfactants such as ethoxylated phenoxyethanols. Such materials are well known in the art and are represented by pdiisobutylphenoxypolyethoxy ethanol, known as Triton X-l00, available from Rohm & Haas, Philadelphia, Pa., nonylphenoxypoly(ethoxy),, ethanol (where n is an integer up to 21 and preferably 9), known as Tergitol TP-9 available from Union Carbide, New York, N.Y., also known as Nonoxynol, available from General Aniline & Film Corp., New York, NY. Other spermicides include ricinoleic acid and mercurial salts such as phenyl mercuric acetate. Among the above, the preferred spermicides are the nonylphenoxypoly(ethoxy),, ethanols with that compound wherein n is 9 being most preferred.
The fibrous mass suitably comprises polymerspermicide fibers having a strand diameter of up to 50 denier (about 5.5 mils.) and preferably from 0.0004 to 0.0015 inches, and a strand length of from 0.25 to 2 inches and preferably 0.5 to 1.25 inches. Normally the mass has a bulk density of 0.1 to 0.3 and preferably 0.1 l to 0.15 gms. per cc in the relaxed state. Such dimensions give a product having the appearance of cotton wadding but having sufficient resiliency and elasticity for filling the cross-section of the vaginal canal and providing occlusion of the deep inner recesses and folds, which might otherwise not receive spermicide were a foam, jelly or cream used. Typically, an effective fibrous mass weighs between 0.75 and 1.50 gms. and preferably 1.00 to 1.25 gms. It may be inserted into the vaginal canal using any of the well-known insertion techniques up to 16-24 hours before coitus. A mass of the weight and dimensions described will slowly dissolve over this period in the natural body fluids and will supply an effective dose of spermicide. It thus provides both a physical and chemical barrier to the union of sperm and ovum in a safe, reliable, topical and aesthetic fashion.
Observations of residence times of various embodiments of the present invention in several types of experimental animals (tabulated in FIG. 1) indicate that it has the desired residence time (about 16 hours) in any warm-blooded animal if used at an appropriate dose. For example, fibrous masses weighing 1.00 to 1.25 gms. will have 0.10 to 0.125 gms. of spermicide associated therewith, and this will ordinarily be suitable for virtually complete spermicidal activity over a 16- hour period. Other compositions of the invention, whether fibrous or molded or extruded shapes, behave similarly and are easily adaptable to insertion into any body cavity therein to release drug.
The following examples are given to illustrate specific embodiments of the present invention:
EXAMPLE 1 lnto an oscillating drum mixer are charged 15,2000 gms. of powdered food grade hydroxypropyl cellulose (available under the tradename Klucel G (available from Hercules, lnc., Wilmington, Del., having a molecular weight of 275,000 and an idealized molar substitution of 3.0 and 1,800 gms. of diisobutylphenoxypolyethoxy ethanol, available under the name of Triton X- 100, from Rohm & Haas, Philadelphia, Pa. The blend is intimately mixed and the resulting intimate mixture is charged into a 2-inch Davis-type single screw extruder equipped with a die containing six /s-inch circular orifices. The Extruder has three zones of melting electrically maintained at 325F, 315F, and 330F, respectively. The strands are cooled as they travel down a 30-foot teflon-coated trough, at the end of which is a means for chopping the strands into /2 inch lengths. The resulting pellets are graded for size, the scraps being returned to the extruder for reuse.
The pellets are then re-extruded as above on a l-inch Davis-type extruder equipped with a die containing a 0.018 inch circular orifice and a means for attenuating the strand as it emerges. This monofilament is collected and is chopped into lengths of between about /2 inch and about 2 inches. These lengths are then treated by standard dry-carding techniques to yield fibrous masses of the cotton wad type.
EXAMPLE II The procedure of Example I is repeated except that 15 percent by weight of the spermicide is substituted for the 10 percent used therein.
EXAMPLE "I The procedure of Example 1 is repeated except that 25 percent by weight of the spermicide is substituted for the 10 percent used therein.
EXAMPLE [V The procedure of Example I is repeated except that 5 percent by weight of nonylphenoxypoly(ethoxy),, ethanol, n 9, (available from Union Carbide Corp., New York, N.Y., under the name of Tergitol TP-9) is substituted for the 10 percent by weight of Triton X-100 used therein.
EXAMPLE V The procedure of Example IV is repeated except that 15 percent by weight of spermicide is substituted for the 10 percent used therein.
EXAMPLE VI A wad of fibers as produced in Example 11 and weighing 0.300 gms. is inserted into the vagina of a female rhesus monkey and is observed periodically. Dissolution of the polymer begins immediately and continues until the wad disappears, a period of from about 17 to about 24 hours.
EXAMPLE Vll Into a tank are charged parts by weight of a watersoluble copolymer of polyvinyl alcohol and allyl alcohol prepared in accordance with known techniques, (See Example I of US. Pat. No. 2,909,502), 5 parts by weight of the spermicide Triton X-l (diisobutylphenoxypolyethoxy ethanol) and sufficient water to make a l percent by weight spinning solution of the spermicide mixture. After thorough mixing, filtration, and de-aeration of the spinning solution, fiber is spun from the solution by the wet method, the coagulating solution for which is a 50C aqueous solution containing about 420g/liter of Na SO and having a pH of about 3.9. The monofilament is collected and chopped into staples (-l inch lengths) suitable for formation into cotton balls by standard dry carding techniques.
EXAMPLE VIII The procedure of Example VII is repeated except that 15 percent by weight of spermicide is substituted for the 5 percent used therein.
EXAMPLE IX The procedure of Example VII is repeated except that 25 percent by weight of spermicide is substituted for the 5 percent used therein.
EXAM PLE X The procedure of Example VII is repeated except that 5 percent by weight of Tergitol TP-9 is substituted for the spermicide used therein.
EXAMPLE XI The procedure of Example X is repeated except that 10 percent by weight of spermicide is substituted for the 5 percent used therein.
EXAMPLE XII The procedure of Example X is repeated except that percent by weight of spermicide is substituted for the 5 percent used therein.
EXAMPLE XIII The procedure of Example VII is repeated except that an equal weight ofeach of ricinoleic acid, and phenyl mercuric acetate is substituted for the 5 percent by weight of Triton X-l00 used therein.
EXAMPLE XIV Several fibers as produced in Example II are dissolved in saline solution and are added to rabbit semen samples in vitro. Immobilization of the sperm is observed to occur. Similar results are obtained when the fibers of Examples l-XIV are utilized in this manner.
What is claimed is:
l. A composition of matter comprising an intimate admixture of a thermoplastic, physiologically-inert hydroxypropyl cellulose or hydroxypropylmethyl cellulose polymer soluble in vaginal fluids shaped as an intra-vaginal medicament applicator and up to 30 weight percent of a vaginal medicament, said intimate mixture having been melt spun by being melted, spun, cast, molded or extruded in the molten state into a fibrous mass of fine fibers, strands, pellets, balls or wads, the entire mass totally dissolving in said vaginal fluid within about 24 hours.
2. The composition of claim 1 wherein the polymer is hydroxypropyl cellulose.
3. The composition of claim 2 in which the medicament is a spermicide, ovacide, antimicrobial, prostaglandin, steroidal or non-steroidal antifertility agent.
4. The composition of claim 3 wherein the medicament is a spermicide.
5. The composition of claim 4 wherein the spermicide is present in an amount ranging from 5 to 25 percent by weight based on the weight of the entire composition.
6. The composition of claim wherein the polymer is a hydroxypropyl cellulose.
7. The composition of claim 6 wherein the spermicide is nonylphenoxypoly(ethoxy),, ethanol wherein n is 9.
8. The composition of claim 6 wherein the spermicide is p-diisobutylphenoxypolyethoxy ethanol.
9. The composition of claim 5 wherein the polymer is a hydroxypropylmethyl cellulose.
10. The composition of claim 9 wherein the spermicide is nonylphenoxypoly(ethoxy),, ethanol or pdiisobutylphenoxypolyethoxy ethanol wherein n is a number up to 21.
11. The composition ofclaim 6 wherein the composition is in the form of a fibrous mass having a fiber diameter of from 0.0004 to 0.0015 inches, and a bulk density of from 0.1 l to 0.15 gms. per cubic cm.
12. The composition of claim 11 wherein the spermicide is nonylphenoxypoly(ethoxy),, ethanol or pdiisobutylphenoxypolyethoxy ethanol wherein n is a number up to 21.
13. The method for delivering a vaginal medicament to a site within the vagina from a solid medicament delivery system which comprises introducing within the vagina an effective amount of the composition of claim 1.
14. The method of claim 13 wherein the composition employed is from 5 to 25 percent by weight ofa spermicide admixed in a hydroxypropyl cellulose.
1 UNITED STATES PATENT OFFICE tmwmmm Patent No. 3, 75,3 Dated Ap l 975 Inventor(s) Roger Homm and Gilbert Katz It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:
rm n w Page 1, in Title, COMPOSITIN should read COMPOSITION In Column 1, line 1, in Title, "COMPOSI'IIN" should read COWOSITION Q In Column 2, line 7, "anti-fertility" should read antifertility In (301 2 line 63, The word cotton should be in quotation marks.
In Column bline 10, "Wilmin ton, Del., having" should read Wilmington, Del.), having igntd an said this fifth Day of August 1975 [SEAL] Arrest.-
RUTH C. MASON C. MARSHALL DANN Allvsring ()jficer ('mnmissimwr of Iarenrs and Trademarks Li J
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3067743 *||28 Oct 1959||11 Dec 1962||Alginate Ind Ltd||Alginic compounds|
|US3108043 *||9 May 1960||22 Oct 1963||Ortho Pharma Corp||Spermicidal sheet-like material|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3946734 *||19 Feb 1975||30 Mar 1976||The United States Of America As Represented By The Secretary Of State||Apparatus for controlling the release of a drug|
|US3982537 *||30 Dec 1974||28 Sep 1976||Louis Bucalo||Dynamic implants and method for implanting the same|
|US4045558 *||8 Oct 1975||30 Aug 1977||Merck & Co., Inc.||Pilocarpine salts|
|US4077407 *||24 Nov 1975||7 Mar 1978||Alza Corporation||Osmotic devices having composite walls|
|US4136145 *||20 Jul 1976||23 Jan 1979||Schering Aktiengesellschaft||Medicament carriers in the form of film having active substance incorporated therein|
|US4179497 *||13 Nov 1978||18 Dec 1979||Merck & Co., Inc.||Solid state ophthalmic medication|
|US4259314 *||10 Dec 1979||31 Mar 1981||Hans Lowey||Method and composition for the preparation of controlled long-acting pharmaceuticals|
|US4265875 *||19 Oct 1979||5 May 1981||Inveresk Research International||Controlled release suppositories|
|US4287175 *||1 Jun 1979||1 Sep 1981||Merck & Co., Inc.||Contact lens wetting agents|
|US4292300 *||20 Jul 1977||29 Sep 1981||Inveresk Research International||Controlled release suppositories|
|US4309997 *||24 Mar 1980||12 Jan 1982||Donald Jack W||Contraceptive and/or antivenereal disease tampon|
|US4343787 *||28 Dec 1978||10 Aug 1982||Merck & Co., Inc.||Shaped ophthalmic inserts for treating dry eye syndrome|
|US4344968 *||10 Dec 1979||17 Aug 1982||Nippon Kayaku Kabushiki Kaisha||Pharmaceutical vehicle|
|US4585651 *||18 Dec 1980||29 Apr 1986||Stolle Research & Development Corporation||Active/passive immunization of the internal female reproductive organs|
|US4673565 *||3 May 1985||16 Jun 1987||E. I. Du Pont De Nemours And Company||Pharmaceutical compositions containing hollow fine tubular drug delivery systems|
|US4732763 *||28 Sep 1984||22 Mar 1988||Stolle Research And Development Corporation||Active/passive immunization of the internal female reproductive organs|
|US4784857 *||2 Jun 1987||15 Nov 1988||Smith And Nephew Associated Companies Plc||Drug delivery device, its preparation and use|
|US4841968 *||26 Sep 1986||27 Jun 1989||Southern Research Institute||Antithrombotic/thrombolytic suture and methods of making and using the same|
|US4855326 *||18 Mar 1988||8 Aug 1989||Fuisz Pharmaceutical Ltd.||Rapidly dissoluble medicinal dosage unit and method of manufacture|
|US4873085 *||18 Mar 1988||10 Oct 1989||Fuisz Pharmaceutical Ltd.||Spun fibrous cosmetic and method of use|
|US4997856 *||30 Nov 1989||5 Mar 1991||Fuisz Pharmaceutical Ltd.||Method of producing compacted dispersable systems|
|US5236734 *||16 Mar 1992||17 Aug 1993||Fuisz Technologies Ltd.||Method of preparing a proteinaceous food product containing a melt spun oleaginous matrix|
|US5238696 *||6 May 1992||24 Aug 1993||Fuisz Technologies Ltd.||Method of preparing a frozen comestible|
|US5268110 *||27 Aug 1992||7 Dec 1993||Fuisz Technologies Ltd.||Oil removing method|
|US5279849 *||12 May 1992||18 Jan 1994||Fuisz Technologies Ltd.||Dispersible polydextrose, compositions containing same and method for the preparation thereof|
|US5286513 *||22 Jun 1993||15 Feb 1994||Fuisz Technologies Ltd.||Proteinaceous food product containing a melt spun oleaginous matrix|
|US5348758 *||20 Oct 1992||20 Sep 1994||Fuisz Technologies Ltd.||Controlled melting point matrix formed with admixtures of a shearform matrix material and an oleaginous material|
|US5374447 *||6 Dec 1993||20 Dec 1994||Fuisz Technologies Ltd.||Method of preparing a reduced-fat meat product|
|US5380473 *||23 Oct 1992||10 Jan 1995||Fuisz Technologies Ltd.||Process for making shearform matrix|
|US5380529 *||23 Aug 1993||10 Jan 1995||Laboratoire Lucchini S.A.||Pharmaceutical, vaginal applicable preparation and a process for its preparation|
|US5387431 *||5 Mar 1992||7 Feb 1995||Fuisz Technologies Ltd.||Saccharide-based matrix|
|US5407676 *||24 Dec 1992||18 Apr 1995||Fuisz Technologies Ltd.||Hydrophilic form of perfluoro compounds and a method of manufacture|
|US5427804 *||15 Mar 1994||27 Jun 1995||Fuisz Technologies Ltd.||Low-fat edible proteins with maltodextrins and low-saturate oils|
|US5429836 *||29 Jul 1993||4 Jul 1995||Fuisz Technologies Ltd.||Saccharide-based matrix|
|US5445769 *||27 Jun 1994||29 Aug 1995||Fuisz Technologies Ltd.||Spinner head for flash flow processing|
|US5456932 *||22 Apr 1994||10 Oct 1995||Fuisz Technologies Ltd.||Method of converting a feedstock to a shearform product and product thereof|
|US5472731 *||22 Mar 1995||5 Dec 1995||Fuisz Technologies Ltd.||Protein based food product|
|US5490993 *||24 Mar 1995||13 Feb 1996||Fuisz Technologies Ltd.||Method of preparing a proteinaceous food product containing a melt spun matrix and product thereof|
|US5501858 *||10 Sep 1993||26 Mar 1996||Fuisz Technologies Ltd.||Rapidly dispersable compositions containing polydextrose|
|US5503862 *||26 May 1995||2 Apr 1996||Fuisz Technologies Ltd.||Method of subjecting a protein-containing material to flash flow processing and product thereof|
|US5512289 *||8 Jun 1995||30 Apr 1996||Johnson & Johnson Consumer Products, Inc.||Spermicidal anti-viral lubricant composition and method of using same|
|US5516537 *||4 May 1993||14 May 1996||Fuisz Technologies Ltd.||Frozen comestibles|
|US5518551 *||10 Sep 1993||21 May 1996||Fuisz Technologies Ltd.||Spheroidal crystal sugar and method of making|
|US5518730 *||3 Jun 1992||21 May 1996||Fuisz Technologies Ltd.||Biodegradable controlled release flash flow melt-spun delivery system|
|US5520859 *||8 Apr 1994||28 May 1996||Fuisz Technologies Ltd.||Method for flash flow processing having feed rate control|
|US5545615 *||22 Sep 1994||13 Aug 1996||Zymogenetics, Inc.||A method of inhibiting fertilization by alpha-1-antitrypsin or antithrombin III|
|US5549917 *||7 Jun 1995||27 Aug 1996||Fuisz Technologies Ltd.||Flash flow formed solloid delivery systems|
|US5556652 *||5 Aug 1994||17 Sep 1996||Fuisz Technologies Ltd.||Comestibles containing stabilized highly odorous flavor component delivery systems|
|US5567439 *||4 Nov 1994||22 Oct 1996||Fuisz Technologies Ltd.||Delivery of controlled-release systems(s)|
|US5576042 *||2 Mar 1994||19 Nov 1996||Fuisz Technologies Ltd.||High intensity particulate polysaccharide based liquids|
|US5582855 *||1 Jul 1994||10 Dec 1996||Fuisz Technologies Ltd.||Flash flow formed solloid delivery systems|
|US5587198 *||31 May 1995||24 Dec 1996||Fuisz Technologies Ltd.||Positive hydration method of preparing confectionery and product therefrom|
|US5593502 *||6 Jun 1995||14 Jan 1997||Fuisz Technologies Ltd.||Method of making crystalline sugar and products resulting therefrom|
|US5597416 *||7 Oct 1993||28 Jan 1997||Fuisz Technologies Ltd.||Method of making crystalline sugar and products resulting therefrom|
|US5597608 *||28 Dec 1994||28 Jan 1997||Fuisz Technologies Ltd.||Saccharide-based matrix incorporating maltodextrin and process for making|
|US5601076 *||5 Jun 1995||11 Feb 1997||Fuisz Technologies Ltd.||Spheroidal crystal sugar and method of making|
|US5622719 *||23 May 1996||22 Apr 1997||Fuisz Technologies Ltd.||Process and apparatus for making rapidly dissolving dosage units and product therefrom|
|US5624684 *||13 May 1992||29 Apr 1997||Fuisz Technologies Ltd.||Enzyme systems|
|US5633027 *||7 Jun 1995||27 May 1997||Fuisz Technologies Ltd.||Confectioneries containing stabilized highly odorous flavor component delivery systems|
|US5651987 *||27 Aug 1993||29 Jul 1997||Fuisz Technologies Ltd.||Ulcer prevention and treatment composition|
|US5654003 *||10 Feb 1994||5 Aug 1997||Fuisz Technologies Ltd.||Process and apparatus for making tablets and tablets made therefrom|
|US5709876 *||7 Jun 1995||20 Jan 1998||Fuisz Technologies Ltd.||Saccharide-based matrix|
|US5728397 *||4 Feb 1997||17 Mar 1998||Fuisz Technologies Ltd.||Polydextrose product and process|
|US5733577 *||16 Aug 1996||31 Mar 1998||Fuisz Technologies Ltd.||Delivery of controlled-release system (s)|
|US5744180 *||23 Oct 1996||28 Apr 1998||Fuisz Technologies Ltd.||Comestibles containing stabilized highly odorous flavor component delivery systems|
|US5804247 *||20 Dec 1996||8 Sep 1998||Fuisz Technologies Ltd.||Positive hydration method of preparing confectionary and product therefrom|
|US5824342 *||9 Apr 1996||20 Oct 1998||Fuisz Technologies Ltd.||Flash flow formed solloid delivery systems|
|US5827563 *||13 Jan 1997||27 Oct 1998||Fuisz Technologies Ltd.||Spheroidal crystal sugar|
|US5843922 *||11 Jun 1996||1 Dec 1998||Fuisz Technologies Ltd.||Preparation of oligosaccharides and products therefrom|
|US5851552 *||16 Aug 1996||22 Dec 1998||Fuisz Technologies, Ltd.||Delivery of controlled-release system(s)|
|US5851553 *||19 Dec 1996||22 Dec 1998||Fuisz Technologies, Ltd.||Process and apparatus for making rapidly dissolving dosage units and product therefrom|
|US5853762 *||16 Aug 1996||29 Dec 1998||Fuisz Technologies Ltd||Delivery of controlled-release system(s)|
|US5866163 *||19 Dec 1996||2 Feb 1999||Fuisz Technologies Ltd.||Process and apparatus for making rapidly dissolving dosage units and product therefrom|
|US5871781 *||19 Dec 1996||16 Feb 1999||Fuisz Technologies Ltd.||Apparatus for making rapidly-dissolving dosage units|
|US5895664 *||14 Jun 1994||20 Apr 1999||Fuisz Technologies Ltd.||Process for forming quickly dispersing comestible unit and product therefrom|
|US6020002 *||5 Nov 1997||1 Feb 2000||Fuisz Technologies Ltd.||Delivery of controlled-release system(s)|
|US6129926 *||13 May 1992||10 Oct 2000||Fuisz Technologies Ltd.||Flash flow processing of thermoplastic polymers and products made therefrom|
|US6841574 *||3 Jan 2003||11 Jan 2005||Nexmed Holdings, Inc.||Topical stabilized prostaglandin E compound dosage forms|
|US20040131664 *||3 Jan 2003||8 Jul 2004||Mo Y. Joseph||Topical stabilized prostaglandin E compound dosage forms|
|US20130136784 *||30 May 2013||Robert J. Staab||Methods for delivery of medication using dissolvable devices|
|DE2940146A1 *||3 Oct 1979||30 Apr 1980||Stolle Res & Dev||Mikroteilchen zur behandlung der inneren weiblichen geschlechtsorgane und deren verwendung|
|EP0016051A1 *||10 Jan 1980||1 Oct 1980||Donald, Enterprises, Inc.||Contraceptive-antivenereal disease tampon|
|EP0250125A2 *||3 Jun 1987||23 Dec 1987||Smith & Nephew plc||Drug delivery device, its preparation and use|
|EP0357665A1 *||14 Apr 1988||14 Mar 1990||Fuisz Pharmaceutical Ltd||Rapidly dissoluble medicinal dosage unit and method of manufacture.|
|WO1988008296A1 *||14 Apr 1988||3 Nov 1988||Fuisz Richard C||A spun fibrous cosmetic and method of use|
|WO1988008298A1 *||14 Apr 1988||3 Nov 1988||Fuisz Richard C||Rapidly dissoluble medicinal dosage unit and method of manufacture|
|WO1990011017A1 *||22 Feb 1990||4 Oct 1990||Fuisz Pharmaceutical Ltd.||A moderated spun fibrous system and method of manuacture|
|U.S. Classification||424/433, 424/426, 424/444|
|International Classification||A61K9/00, A61K45/08, A61K45/00, A61K47/30, A61K9/02, A61K9/70|
|Cooperative Classification||A61K9/70, A61K9/0034|
|European Classification||A61K9/00M8, A61K9/70|