US3874381A - Dual nozzle intranasal delivery device - Google Patents

Dual nozzle intranasal delivery device Download PDF

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Publication number
US3874381A
US3874381A US473373A US47337374A US3874381A US 3874381 A US3874381 A US 3874381A US 473373 A US473373 A US 473373A US 47337374 A US47337374 A US 47337374A US 3874381 A US3874381 A US 3874381A
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passage
container
turret
cavity
housing
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US473373A
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Ronald Baum
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SmithKline Beecham Corp
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SmithKline Corp
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Assigned to SMITHKLINE BECKMAN CORPORATION reassignment SMITHKLINE BECKMAN CORPORATION CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). EFFECTIVE DATE: 03/04/82 Assignors: SMITHKLINE CORPORATION
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • a dual nozzle intranasal delivery device has a housing with a cavity for the reception of a container having a pierceable stopper and having a first passage communicating with said cavity.
  • a hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container.
  • a pair of substantially parallel spray nozzles communicate with a second passage in the housing.
  • a turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle.
  • a dual nozzle intranasal delivery device has a housing with a cavity for the reception ofa container having a pierceable stopper and having a first passage communicating with said cavity.
  • a hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container.
  • a pair of substantially parallel spray nozzles communicate with a second passage in the housing.
  • a turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle.
  • FIG. I is an elevational view of an intranasal delivery device in accordance with the invention together with a container and a syringe;
  • FIG. 2 is a vertical section through the intranasal device of FIG. 1 showing a container and a syringe positioned to communicate with the container;
  • FIG. 3 is a vertical section through the intranasal device of FIG. 1 partially broken away and showing a syringe positioned to discharge liquid through the nozzles;
  • FIG. 4 is an elevational view of the intranasal device of FIG. 1 with a syringe positioned for the discharge of liquid through the nozzles;
  • FIG. 5 is a view taken on the plane indicated by the line 5-5 in FIG. I and showing a syringe positioned for the discharge of liquid through the nozzles.
  • An intranasal delivery device 2 has a body 4 formed from two mirror image portions 6 and 8 which are secured together by screws indicated at 10.
  • the body 4 has a cavity 12 which is adapted to receive a container 14 having a pierceable stopper 16 of rubber or the like. Stopper 16 is held in position by a metal cap 18.
  • Container 14 is well known in the art.
  • a passage 22 is in communication with cavity 12. Secured by a pressed fit in cavity 22 is a hollow needle 24, which has a sharp chamfered end 25, extends into cavity 12 and is adapted to pierce the pierceable stopper 16 as shown in FIG. 2.
  • a cylindrical turret member 26 is rotatably mounted in a partial cylindrical opening 28 in body 4 which extends for somewhat more than 180 in order to lock in the turret member 26.
  • Turret member 26 has a passage 30 which has an enlarged portion 32 and which is adapted to communicate with passage 22 and is connected to a tapered opening 34 which is adapted to receive a tapered nozzle 36 of a syringe 38.
  • Turret member 26 can be rotated clockwise as viewed in FIG. 2 to place it in communication with a passage 42 in body 4.
  • Passage 42 communicates with a pair of substantially parallel nozzles 44 and 46 which have respectively reduced discharge passages 48 and 50.
  • Nozzles 44 and 46 are spaced so as to permit the nozzles to be simultaneously introduced into the patients nostrils.
  • a sector stop member 60 is secured to the exterior of turret member 26, for example by an adhesive, and engages body 4 to limit the rotation of turret 26 so as to communicate with passage 24 in one position and with passage 42 in its alternate position of maximum rotation.
  • Syringe 38 has a rubber stopper 64 to close off nozzle 36 and a plunger 66 to cause liquid to flow in and out of syringe 38.
  • a lyophilized biological such as a lyophilized medicament tablet 70 is in container 14
  • container I4 is inserted into cavity 12 and thrust home causing needle 24 to pierce pierceable stopper 16 as shown in FIG. 2.
  • a syringe 38 containing a reconstituting liquid will have its cover 64 removed with nozzle 36 pointing up and nozzle 36 inserted into opening 34.
  • plunger 66 is advanced to cause liquid to move out of syringe 38 through passage 30, passage 22 and needle 24 into container 14.
  • the plunger 66 is retracted to withdraw the solution from container 14 into syringe 38.
  • the syringe 38 then is moved to cause the turret member 26 to rotate so that passage 30 is in communication with passage 42.
  • Nozzles 44 and 46 are placed by the user in his nostrils.
  • plunger 66 is advanced to cause the discharge of fluid from syringe 38 into passage 42 and thence into the patients nose through nozzles 44 and 46.
  • a dual nozzle intranasal delivery device comprising:
  • said housing having a cavity for the reception of a container having a pierceable stopper and a first passage communicating with said cavity
  • each of said passages communicating with said opening.
  • a turret member mounted in said cylindrical opening and having a passage of which one end alternatively communicates with the first and second pas- 3 4 sages and the other end'is provided with an opening 2.
  • a device in accordance with claim 1 having stop for the reception of a syringe nozzle whereby a symeans to limit the rotation of the turret to facilitate the ringe can be placed in communication with the alignment of the passage in the turret with the first and container and then by rotation of the turret placed second passages. in communication with the second passage. 5

Abstract

A dual nozzle intranasal delivery device has a housing with a cavity for the reception of a container having a pierceable stopper and having a first passage communicating with said cavity. A hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container. A pair of substantially parallel spray nozzles communicate with a second passage in the housing. A turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle. Through the use of the turret a syringe can be placed in communication with the container and then, by rotating the turret, placed in communication with the second passage to provide for taking liquid from the container and delivering it through the nozzles.

Description

Baum
[451 Apr. 1, 1975 1 DUAL NOZZLE INTRANASAL DELIVERY DEVICE [75] Inventor: Ronald Baum, Merion, Pa.
[73] Assignee: Smithkline Corporation,
Philadelphia, Pa.
[22] Filed: May 28, 1974 [21] Appl. No.: 473,373
Primary Examiner-Richard A. Gaudet 1 Assistant Examiner-Henry J. Recla Attorney, Agent, or Firm-Smith, Harding, Earley & Folimer [5 7] ABSTRACT A dual nozzle intranasal delivery device has a housing with a cavity for the reception of a container having a pierceable stopper and having a first passage communicating with said cavity. A hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container. A pair of substantially parallel spray nozzles communicate with a second passage in the housing. A turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle. Through the use of the turret a syringe can be placed in communication with the container and then, by rotating the turret, placed in communication with the second passage to provide for taking liquid from the container and delivering it through the nozzles.
2 Claims, 5 Drawing Figures FI'XTENTEU APR 7 1975 DUAL NOZZLE INTRANASAL DELIVERY DEVICE BACKGROUND OF THE INVENTION It is known to employ a pair of adjacent spray nozzles communicating with a conduit which is adapted to be connected to a syringe to deliver vaccine such as a flu vaccine or a measles vaccine in about equal doses to each nostril. While this operation is simple and effective, it still leaves the patient with a difficult problem in getting the dosage in liquid form into the syringe. This is particularly the case where the biological to be employed is lyophilized. In accordance with this invention a lyophilized medicament can be placed in solution in a syringe under sterile conditions with great ease by an unskilled patient.
BRIEF SUMMARY OF THE INVENTION A dual nozzle intranasal delivery device has a housing with a cavity for the reception ofa container having a pierceable stopper and having a first passage communicating with said cavity. A hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container. A pair of substantially parallel spray nozzles communicate with a second passage in the housing. A turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle. Through the use of the turret a syringe can be placed in communication with the container and then, by rotating the turret, placed in communication with the second passage to provide for taking liquid from the container and delivering it through the nozzles.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. I is an elevational view of an intranasal delivery device in accordance with the invention together with a container and a syringe;
FIG. 2 is a vertical section through the intranasal device of FIG. 1 showing a container and a syringe positioned to communicate with the container;
FIG. 3 is a vertical section through the intranasal device of FIG. 1 partially broken away and showing a syringe positioned to discharge liquid through the nozzles;
FIG. 4 is an elevational view of the intranasal device of FIG. 1 with a syringe positioned for the discharge of liquid through the nozzles; and
FIG. 5 is a view taken on the plane indicated by the line 5-5 in FIG. I and showing a syringe positioned for the discharge of liquid through the nozzles.
DETAILED DESCRIPTION An intranasal delivery device 2 has a body 4 formed from two mirror image portions 6 and 8 which are secured together by screws indicated at 10. The body 4 has a cavity 12 which is adapted to receive a container 14 having a pierceable stopper 16 of rubber or the like. Stopper 16 is held in position by a metal cap 18. Container 14 is well known in the art.
A passage 22 is in communication with cavity 12. Secured by a pressed fit in cavity 22 is a hollow needle 24, which has a sharp chamfered end 25, extends into cavity 12 and is adapted to pierce the pierceable stopper 16 as shown in FIG. 2. I
A cylindrical turret member 26 is rotatably mounted in a partial cylindrical opening 28 in body 4 which extends for somewhat more than 180 in order to lock in the turret member 26. Turret member 26 has a passage 30 which has an enlarged portion 32 and which is adapted to communicate with passage 22 and is connected to a tapered opening 34 which is adapted to receive a tapered nozzle 36 of a syringe 38.
Turret member 26 can be rotated clockwise as viewed in FIG. 2 to place it in communication with a passage 42 in body 4. Passage 42 communicates with a pair of substantially parallel nozzles 44 and 46 which have respectively reduced discharge passages 48 and 50. Nozzles 44 and 46 are spaced so as to permit the nozzles to be simultaneously introduced into the patients nostrils.
A sector stop member 60 is secured to the exterior of turret member 26, for example by an adhesive, and engages body 4 to limit the rotation of turret 26 so as to communicate with passage 24 in one position and with passage 42 in its alternate position of maximum rotation.
Syringe 38 has a rubber stopper 64 to close off nozzle 36 and a plunger 66 to cause liquid to flow in and out of syringe 38.
OPERATION Assuming that a lyophilized biological such as a lyophilized medicament tablet 70 is in container 14, container I4 is inserted into cavity 12 and thrust home causing needle 24 to pierce pierceable stopper 16 as shown in FIG. 2. A syringe 38 containing a reconstituting liquid will have its cover 64 removed with nozzle 36 pointing up and nozzle 36 inserted into opening 34. With passage 30 lined up'with passage 22, plunger 66 is advanced to cause liquid to move out of syringe 38 through passage 30, passage 22 and needle 24 into container 14. When the tablet 70' has gone into solution, the plunger 66 is retracted to withdraw the solution from container 14 into syringe 38. The syringe 38 then is moved to cause the turret member 26 to rotate so that passage 30 is in communication with passage 42. Nozzles 44 and 46 are placed by the user in his nostrils. Again, plunger 66 is advanced to cause the discharge of fluid from syringe 38 into passage 42 and thence into the patients nose through nozzles 44 and 46.
It will be understood that the foregoing description is illustrative and is not limiting.
I claim:
1. A dual nozzle intranasal delivery device comprising:
a housing,
said housing having a cavity for the reception of a container having a pierceable stopper and a first passage communicating with said cavity,
a hollow needle secured in said passage and extending into the cavity, said needle being adapted to penetrate the stopper of said container,
a pair of adjacent nozzles having substantially parallel axes a second passage in said housing communicating with said no'zzles,
a cylindrical opening in said housing,
each of said passages communicating with said opening.
a turret member mounted in said cylindrical opening and having a passage of which one end alternatively communicates with the first and second pas- 3 4 sages and the other end'is provided with an opening 2. A device in accordance with claim 1 having stop for the reception of a syringe nozzle whereby a symeans to limit the rotation of the turret to facilitate the ringe can be placed in communication with the alignment of the passage in the turret with the first and container and then by rotation of the turret placed second passages. in communication with the second passage. 5

Claims (2)

1. A dual nozzle intranasal delivery device comprising: a housing, said housing having a cavity for the reception of a container having a pierceable stopper and a first passage communicating with said cavity, a hollow needle secured in said passage and extending into the cavity, said needle being adapted to penetrate the stopper of said container, a pair of adjacent nozzles having substantially parallel axes a second passage in said housing communicating with said nozzles, a cylindrical opening in said housing, each of said passages communicating with said opening. a turret member mounted in said cylindrical opening and having a passage of which one end alternatively communicates with the first and second passages and the other end is provided with an opening for the reception of a syringe nozzle whereby a syringe can be placed in communication with the container and then by rotation of the turret placed in communication with the second passage.
2. A device in accordance with claim 1 having stop means to limit the rotation of the turret to facilitate the alignment of the passage in the turret with the first and second passages.
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Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551139A (en) * 1982-02-08 1985-11-05 Marion Laboratories, Inc. Method and apparatus for burn wound treatment
US4856567A (en) * 1986-08-04 1989-08-15 Sicim Spa Loader-mixer device for endermic injectors
US4890340A (en) * 1988-09-26 1990-01-02 Lovitt Harold B Self-contained hand-held bidet
WO1991007940A1 (en) * 1989-12-01 1991-06-13 Lovitt Harold B Self-contained hand-held bidet
US5419316A (en) * 1991-08-21 1995-05-30 Bernstein; Jerome Anesthesia evaporators
US5429600A (en) * 1994-05-02 1995-07-04 Heinke; Richard M. Method for delivering a pharmaceutical into the nostril of an animal
US5433191A (en) * 1992-05-15 1995-07-18 Habley Medical Technology Corp. Medication sprayer
US5601077A (en) * 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
EP0821975A1 (en) * 1996-07-31 1998-02-04 Novartis AG (Novartis SA) (Novartis Inc.) Dosing device for fluids
US5755221A (en) * 1990-09-12 1998-05-26 Bisgaard; Hans Aerosol inhaler with piston dump
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
WO2002074375A1 (en) * 2001-03-20 2002-09-26 Aradigm Corporation Aerosol generation using sterile multiple dose containers
US20030101995A1 (en) * 2001-06-15 2003-06-05 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US6718969B1 (en) * 2002-05-28 2004-04-13 Darren Rubin Medication dosage inhaler system
US6810874B1 (en) * 1999-04-23 2004-11-02 Innovata Biomed Limited Powder inhaler for combined medicament
US6810873B1 (en) * 1999-04-23 2004-11-02 Innovata Biomed Limited Powder inhaler for combined medicament
US20050005933A1 (en) * 2001-06-20 2005-01-13 Kari Seppala Powder inhaler
US20050101937A1 (en) * 2003-11-06 2005-05-12 Nova-Tech Engineering, Inc. Apparatus and method for nasal delivery of compositions to birds
US20050131357A1 (en) * 2003-12-16 2005-06-16 Denton Marshall T. Vial multi-access adapter
US20050201946A1 (en) * 1999-09-24 2005-09-15 Smithkline Beecham Biologicals Sa Intranasal influenza virus vaccine
US20050241634A1 (en) * 1996-04-19 2005-11-03 Dieter Hochrainer Two-chamber cartridge for propellant-free metering aerosols
US20060292085A1 (en) * 2001-02-06 2006-12-28 Innovata Biomed Limited Medicaments
US20070039618A1 (en) * 1999-06-05 2007-02-22 Innovata Biomed Limited Delivery system
US7219665B1 (en) 1999-09-04 2007-05-22 Innovata Biomed Limited Delivery device
US7464704B2 (en) 2001-11-23 2008-12-16 Innovata Biomed Limited Medicament delivery assembly
US20110218510A1 (en) * 2010-03-02 2011-09-08 Louis Bojrab Vial holder
EP2490733A1 (en) * 2009-09-29 2012-08-29 Marc J. Salzman Syringe-attached topical anesthetic dispenser
US8511302B2 (en) 2004-04-24 2013-08-20 Innovata Biomed Limited Dose counter mechanisms for medicament delivery devices
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
US20160318051A1 (en) * 2014-01-13 2016-11-03 Aptar France Sas Method for using an assembly for dispensing a fluid product
EP4052746A4 (en) * 2019-11-06 2023-11-22 Nipro Corporation Syringe-type ejection device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US708224A (en) * 1901-10-18 1902-09-02 Frank C Gundlach Syringe.
US1930929A (en) * 1931-05-12 1933-10-17 Eisenberg Moses Joel Hypodermic implement
US3330277A (en) * 1964-08-17 1967-07-11 Scherer Corp R P Multidose hypodermic injector

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US708224A (en) * 1901-10-18 1902-09-02 Frank C Gundlach Syringe.
US1930929A (en) * 1931-05-12 1933-10-17 Eisenberg Moses Joel Hypodermic implement
US3330277A (en) * 1964-08-17 1967-07-11 Scherer Corp R P Multidose hypodermic injector

Cited By (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551139A (en) * 1982-02-08 1985-11-05 Marion Laboratories, Inc. Method and apparatus for burn wound treatment
US4856567A (en) * 1986-08-04 1989-08-15 Sicim Spa Loader-mixer device for endermic injectors
US4890340A (en) * 1988-09-26 1990-01-02 Lovitt Harold B Self-contained hand-held bidet
US5097540A (en) * 1988-09-26 1992-03-24 Lovitt Harold B Self-contained hand-held bidet
WO1991007940A1 (en) * 1989-12-01 1991-06-13 Lovitt Harold B Self-contained hand-held bidet
US5755221A (en) * 1990-09-12 1998-05-26 Bisgaard; Hans Aerosol inhaler with piston dump
US5601077A (en) * 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
US5419316A (en) * 1991-08-21 1995-05-30 Bernstein; Jerome Anesthesia evaporators
US5433191A (en) * 1992-05-15 1995-07-18 Habley Medical Technology Corp. Medication sprayer
US5429600A (en) * 1994-05-02 1995-07-04 Heinke; Richard M. Method for delivering a pharmaceutical into the nostril of an animal
US7980243B2 (en) 1996-04-19 2011-07-19 Boehringer Ingelheim Pharma Gmbh & Co., Kg Two-chamber cartridge for propellant-free metering aerosols
US7213593B2 (en) 1996-04-19 2007-05-08 Boehringer Ingelheim Kg Two-chamber cartridge for propellant-free metering aerosols
US20080033391A1 (en) * 1996-04-19 2008-02-07 Boehringer Ingelheim Kg Two-Chamber Cartridge For Propellant-Free Metering Aerosols
US20050241634A1 (en) * 1996-04-19 2005-11-03 Dieter Hochrainer Two-chamber cartridge for propellant-free metering aerosols
US7793655B2 (en) 1996-04-19 2010-09-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-chamber cartridge for propellant-free metering aerosols
EP0821975A1 (en) * 1996-07-31 1998-02-04 Novartis AG (Novartis SA) (Novartis Inc.) Dosing device for fluids
US6161731A (en) * 1996-07-31 2000-12-19 Novartis Ag Dosing device
US6810873B1 (en) * 1999-04-23 2004-11-02 Innovata Biomed Limited Powder inhaler for combined medicament
US6810874B1 (en) * 1999-04-23 2004-11-02 Innovata Biomed Limited Powder inhaler for combined medicament
US7207330B1 (en) 1999-06-05 2007-04-24 Innovata Biomed Limited Delivery system
US20070039618A1 (en) * 1999-06-05 2007-02-22 Innovata Biomed Limited Delivery system
US20070163580A1 (en) * 1999-09-04 2007-07-19 Innovata Biomed Limited Delivery device
US8205614B2 (en) 1999-09-04 2012-06-26 Innovata Biomed Limited Delivery device
US7219665B1 (en) 1999-09-04 2007-05-22 Innovata Biomed Limited Delivery device
US7571724B2 (en) 1999-09-04 2009-08-11 Innovata Biomed Limited Delivery device
US7571723B2 (en) 1999-09-04 2009-08-11 Innovata Biomed Limited Delivery device
US20050201946A1 (en) * 1999-09-24 2005-09-15 Smithkline Beecham Biologicals Sa Intranasal influenza virus vaccine
US6382204B1 (en) 1999-10-14 2002-05-07 Becton Dickinson And Company Drug delivery system including holder and drug container
US6530371B2 (en) 1999-10-14 2003-03-11 Becton, Dickinson And Company Drug delivery system including holder and drug container
US20060292085A1 (en) * 2001-02-06 2006-12-28 Innovata Biomed Limited Medicaments
US20100136121A1 (en) * 2001-02-06 2010-06-03 Innovata Biomed Limited Medicaments
WO2002074375A1 (en) * 2001-03-20 2002-09-26 Aradigm Corporation Aerosol generation using sterile multiple dose containers
EP1402913A1 (en) * 2001-06-15 2004-03-31 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US8443799B2 (en) 2001-06-15 2013-05-21 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
EP1688133A1 (en) * 2001-06-15 2006-08-09 Otsuka Pharmaceutical Co., Ltd. Freeze-dried composition for transpulmonary administration
HRP20040033B1 (en) * 2001-06-15 2007-11-30 Otsuka Pharmaceutical Co. Dry powder inhalation system for transpulmonary administration
US20060073105A1 (en) * 2001-06-15 2006-04-06 Chikamasa Yamashita Novel dry powder inhalation system for transpulmonary administration
CN100427077C (en) * 2001-06-15 2008-10-22 大塚制药株式会社 Dry powder inhalation system for transpulmonary administration
US7448379B2 (en) 2001-06-15 2008-11-11 Otsuka Pharmaceutical Co., Ltd. Composition, vessel, dry powder inhalation system, and related methods for transpulmonary administration
US20070065371A2 (en) * 2001-06-15 2007-03-22 Otsuka Pharmaceutical Co., Ltd. Novel Dry Powder Inhalation System For Transpulmonary Administration
US20090095293A1 (en) * 2001-06-15 2009-04-16 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US20090126732A1 (en) * 2001-06-15 2009-05-21 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US8333193B2 (en) 2001-06-15 2012-12-18 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US20030101995A1 (en) * 2001-06-15 2003-06-05 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
EP1402913A4 (en) * 2001-06-15 2004-12-01 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary administration
US7735485B2 (en) 2001-06-15 2010-06-15 Otsuka Pharmaceutical Co., Ltd. Dry powder inhalation system for transpulmonary administration
US20050005933A1 (en) * 2001-06-20 2005-01-13 Kari Seppala Powder inhaler
US8550070B2 (en) 2001-06-20 2013-10-08 Orion Corporation Powder inhaler
US7464704B2 (en) 2001-11-23 2008-12-16 Innovata Biomed Limited Medicament delivery assembly
US8800550B2 (en) 2001-11-23 2014-08-12 Innovata Biomed Limited Medicament delivery assembly
US6718969B1 (en) * 2002-05-28 2004-04-13 Darren Rubin Medication dosage inhaler system
US20050101937A1 (en) * 2003-11-06 2005-05-12 Nova-Tech Engineering, Inc. Apparatus and method for nasal delivery of compositions to birds
US8499721B2 (en) * 2003-11-06 2013-08-06 Nova-Tech Engineering, Inc. Apparatus and method for nasal delivery of compositions to birds
US20110083665A1 (en) * 2003-12-16 2011-04-14 Wolfe Tory Medical, Inc. Vial multi-access adapter
US8210166B2 (en) * 2003-12-16 2012-07-03 Wolfe Tory Medical, Inc. Vial multi-access adapter
US20050131357A1 (en) * 2003-12-16 2005-06-16 Denton Marshall T. Vial multi-access adapter
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
US8511302B2 (en) 2004-04-24 2013-08-20 Innovata Biomed Limited Dose counter mechanisms for medicament delivery devices
EP2490733A1 (en) * 2009-09-29 2012-08-29 Marc J. Salzman Syringe-attached topical anesthetic dispenser
EP2490733A4 (en) * 2009-09-29 2013-07-17 Marc J Salzman Syringe-attached topical anesthetic dispenser
US20110218510A1 (en) * 2010-03-02 2011-09-08 Louis Bojrab Vial holder
US20160318051A1 (en) * 2014-01-13 2016-11-03 Aptar France Sas Method for using an assembly for dispensing a fluid product
US11559821B2 (en) * 2014-01-13 2023-01-24 Aptar France Sas Method for using an assembly for dispensing a fluid product
EP4052746A4 (en) * 2019-11-06 2023-11-22 Nipro Corporation Syringe-type ejection device

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