Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3874381 A
Publication typeGrant
Publication date1 Apr 1975
Filing date28 May 1974
Priority date28 May 1974
Publication numberUS 3874381 A, US 3874381A, US-A-3874381, US3874381 A, US3874381A
InventorsBaum Ronald
Original AssigneeSmithkline Corp
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Dual nozzle intranasal delivery device
US 3874381 A
Abstract
A dual nozzle intranasal delivery device has a housing with a cavity for the reception of a container having a pierceable stopper and having a first passage communicating with said cavity. A hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container. A pair of substantially parallel spray nozzles communicate with a second passage in the housing. A turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle. Through the use of the turret a syringe can be placed in communication with the container and then, by rotating the turret, placed in communication with the second passage to provide for taking liquid from the container and delivering it through the nozzles.
Images(2)
Previous page
Next page
Description  (OCR text may contain errors)

Baum

[451 Apr. 1, 1975 1 DUAL NOZZLE INTRANASAL DELIVERY DEVICE [75] Inventor: Ronald Baum, Merion, Pa.

[73] Assignee: Smithkline Corporation,

Philadelphia, Pa.

[22] Filed: May 28, 1974 [21] Appl. No.: 473,373

Primary Examiner-Richard A. Gaudet 1 Assistant Examiner-Henry J. Recla Attorney, Agent, or Firm-Smith, Harding, Earley & Folimer [5 7] ABSTRACT A dual nozzle intranasal delivery device has a housing with a cavity for the reception of a container having a pierceable stopper and having a first passage communicating with said cavity. A hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container. A pair of substantially parallel spray nozzles communicate with a second passage in the housing. A turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle. Through the use of the turret a syringe can be placed in communication with the container and then, by rotating the turret, placed in communication with the second passage to provide for taking liquid from the container and delivering it through the nozzles.

2 Claims, 5 Drawing Figures FI'XTENTEU APR 7 1975 DUAL NOZZLE INTRANASAL DELIVERY DEVICE BACKGROUND OF THE INVENTION It is known to employ a pair of adjacent spray nozzles communicating with a conduit which is adapted to be connected to a syringe to deliver vaccine such as a flu vaccine or a measles vaccine in about equal doses to each nostril. While this operation is simple and effective, it still leaves the patient with a difficult problem in getting the dosage in liquid form into the syringe. This is particularly the case where the biological to be employed is lyophilized. In accordance with this invention a lyophilized medicament can be placed in solution in a syringe under sterile conditions with great ease by an unskilled patient.

BRIEF SUMMARY OF THE INVENTION A dual nozzle intranasal delivery device has a housing with a cavity for the reception ofa container having a pierceable stopper and having a first passage communicating with said cavity. A hollow needle secured in the passage extends into the cavity and is adapted to penetrate the stopper of the container. A pair of substantially parallel spray nozzles communicate with a second passage in the housing. A turret member is rotatably mounted in the housing and has a passage adapted to communicate alternatively with the first and second passages and having an opening for the reception of a syringe nozzle. Through the use of the turret a syringe can be placed in communication with the container and then, by rotating the turret, placed in communication with the second passage to provide for taking liquid from the container and delivering it through the nozzles.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. I is an elevational view of an intranasal delivery device in accordance with the invention together with a container and a syringe;

FIG. 2 is a vertical section through the intranasal device of FIG. 1 showing a container and a syringe positioned to communicate with the container;

FIG. 3 is a vertical section through the intranasal device of FIG. 1 partially broken away and showing a syringe positioned to discharge liquid through the nozzles;

FIG. 4 is an elevational view of the intranasal device of FIG. 1 with a syringe positioned for the discharge of liquid through the nozzles; and

FIG. 5 is a view taken on the plane indicated by the line 5-5 in FIG. I and showing a syringe positioned for the discharge of liquid through the nozzles.

DETAILED DESCRIPTION An intranasal delivery device 2 has a body 4 formed from two mirror image portions 6 and 8 which are secured together by screws indicated at 10. The body 4 has a cavity 12 which is adapted to receive a container 14 having a pierceable stopper 16 of rubber or the like. Stopper 16 is held in position by a metal cap 18. Container 14 is well known in the art.

A passage 22 is in communication with cavity 12. Secured by a pressed fit in cavity 22 is a hollow needle 24, which has a sharp chamfered end 25, extends into cavity 12 and is adapted to pierce the pierceable stopper 16 as shown in FIG. 2. I

A cylindrical turret member 26 is rotatably mounted in a partial cylindrical opening 28 in body 4 which extends for somewhat more than 180 in order to lock in the turret member 26. Turret member 26 has a passage 30 which has an enlarged portion 32 and which is adapted to communicate with passage 22 and is connected to a tapered opening 34 which is adapted to receive a tapered nozzle 36 of a syringe 38.

Turret member 26 can be rotated clockwise as viewed in FIG. 2 to place it in communication with a passage 42 in body 4. Passage 42 communicates with a pair of substantially parallel nozzles 44 and 46 which have respectively reduced discharge passages 48 and 50. Nozzles 44 and 46 are spaced so as to permit the nozzles to be simultaneously introduced into the patients nostrils.

A sector stop member 60 is secured to the exterior of turret member 26, for example by an adhesive, and engages body 4 to limit the rotation of turret 26 so as to communicate with passage 24 in one position and with passage 42 in its alternate position of maximum rotation.

Syringe 38 has a rubber stopper 64 to close off nozzle 36 and a plunger 66 to cause liquid to flow in and out of syringe 38.

OPERATION Assuming that a lyophilized biological such as a lyophilized medicament tablet 70 is in container 14, container I4 is inserted into cavity 12 and thrust home causing needle 24 to pierce pierceable stopper 16 as shown in FIG. 2. A syringe 38 containing a reconstituting liquid will have its cover 64 removed with nozzle 36 pointing up and nozzle 36 inserted into opening 34. With passage 30 lined up'with passage 22, plunger 66 is advanced to cause liquid to move out of syringe 38 through passage 30, passage 22 and needle 24 into container 14. When the tablet 70' has gone into solution, the plunger 66 is retracted to withdraw the solution from container 14 into syringe 38. The syringe 38 then is moved to cause the turret member 26 to rotate so that passage 30 is in communication with passage 42. Nozzles 44 and 46 are placed by the user in his nostrils. Again, plunger 66 is advanced to cause the discharge of fluid from syringe 38 into passage 42 and thence into the patients nose through nozzles 44 and 46.

It will be understood that the foregoing description is illustrative and is not limiting.

I claim:

1. A dual nozzle intranasal delivery device comprising:

a housing,

said housing having a cavity for the reception of a container having a pierceable stopper and a first passage communicating with said cavity,

a hollow needle secured in said passage and extending into the cavity, said needle being adapted to penetrate the stopper of said container,

a pair of adjacent nozzles having substantially parallel axes a second passage in said housing communicating with said no'zzles,

a cylindrical opening in said housing,

each of said passages communicating with said opening.

a turret member mounted in said cylindrical opening and having a passage of which one end alternatively communicates with the first and second pas- 3 4 sages and the other end'is provided with an opening 2. A device in accordance with claim 1 having stop for the reception of a syringe nozzle whereby a symeans to limit the rotation of the turret to facilitate the ringe can be placed in communication with the alignment of the passage in the turret with the first and container and then by rotation of the turret placed second passages. in communication with the second passage. 5

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US708224 *18 Oct 19012 Sep 1902Frank C GundlachSyringe.
US1930929 *12 May 193117 Oct 1933Eisenberg Moses JoelHypodermic implement
US3330277 *17 Aug 196411 Jul 1967Scherer Corp R PMultidose hypodermic injector
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4551139 *8 Feb 19825 Nov 1985Marion Laboratories, Inc.Method and apparatus for burn wound treatment
US4856567 *22 Jul 198715 Aug 1989Sicim SpaLoader-mixer device for endermic injectors
US4890340 *26 Sep 19882 Jan 1990Lovitt Harold BSelf-contained hand-held bidet
US5097540 *1 Dec 198924 Mar 1992Lovitt Harold BSelf-contained hand-held bidet
US5419316 *6 Aug 199230 May 1995Bernstein; JeromeAnesthesia evaporators
US5429600 *2 May 19944 Jul 1995Heinke; Richard M.Method for delivering a pharmaceutical into the nostril of an animal
US5433191 *6 Dec 199318 Jul 1995Habley Medical Technology Corp.Medication sprayer
US5601077 *7 Aug 199111 Feb 1997Becton, Dickinson And CompanyNasal syringe sprayer with removable dose limiting structure
US5755221 *24 Oct 199426 May 1998Bisgaard; HansAerosol inhaler with piston dump
US6161731 *23 Jul 199719 Dec 2000Novartis AgDosing device
US638220414 Oct 19997 May 2002Becton Dickinson And CompanyDrug delivery system including holder and drug container
US65303715 Nov 200111 Mar 2003Becton, Dickinson And CompanyDrug delivery system including holder and drug container
US6718969 *28 May 200213 Apr 2004Darren RubinMedication dosage inhaler system
US6810873 *20 Apr 20002 Nov 2004Innovata Biomed LimitedPowder inhaler for combined medicament
US6810874 *20 Apr 20002 Nov 2004Innovata Biomed LimitedPowder inhaler for combined medicament
US72073305 Jun 200024 Apr 2007Innovata Biomed LimitedDelivery system
US721359311 Jul 20058 May 2007Boehringer Ingelheim KgTwo-chamber cartridge for propellant-free metering aerosols
US72196654 Sep 200022 May 2007Innovata Biomed LimitedDelivery device
US744837914 Jun 200211 Nov 2008Otsuka Pharmaceutical Co., Ltd.Composition, vessel, dry powder inhalation system, and related methods for transpulmonary administration
US746470422 Nov 200216 Dec 2008Innovata Biomed LimitedMedicament delivery assembly
US75717231 Mar 200711 Aug 2009Innovata Biomed LimitedDelivery device
US75717241 Mar 200711 Aug 2009Innovata Biomed LimitedDelivery device
US773548512 Dec 200315 Jun 2010Otsuka Pharmaceutical Co., Ltd.Dry powder inhalation system for transpulmonary administration
US779365511 Jul 200514 Sep 2010Boehringer Ingelheim Pharma Gmbh & Co. KgTwo-chamber cartridge for propellant-free metering aerosols
US79802437 Jun 200719 Jul 2011Boehringer Ingelheim Pharma Gmbh & Co., KgTwo-chamber cartridge for propellant-free metering aerosols
US820561410 Aug 200926 Jun 2012Innovata Biomed LimitedDelivery device
US8210166 *16 Dec 20033 Jul 2012Wolfe Tory Medical, Inc.Vial multi-access adapter
US833319310 Oct 200818 Dec 2012Otsuka Pharmaceutical Co., Ltd.Dry powder inhalation system for transpulmonary administration
US844379930 Aug 200821 May 2013Otsuka Pharmaceutical Co., Ltd.Dry powder inhalation system for transpulmonary administration
US8499721 *6 Nov 20036 Aug 2013Nova-Tech Engineering, Inc.Apparatus and method for nasal delivery of compositions to birds
US851130222 Apr 200520 Aug 2013Innovata Biomed LimitedDose counter mechanisms for medicament delivery devices
US855007020 Jun 20028 Oct 2013Orion CorporationPowder inhaler
US20110083665 *13 Dec 201014 Apr 2011Wolfe Tory Medical, Inc.Vial multi-access adapter
US20110218510 *2 Mar 20108 Sep 2011Louis BojrabVial holder
CN100427077C14 Jun 200222 Oct 2008大塚制药株式会社Dry powder inhalation system for transpulmonary administration
EP0821975A1 *31 Jul 19964 Feb 1998Novartis AG (Novartis SA) (Novartis Inc.)Dosing device for fluids
EP1402913A1 *14 Jun 200231 Mar 2004Otsuka Pharmaceutical Co., Ltd.Dry powder inhalation system for transpulmonary administration
EP1688133A1 *14 Jun 20029 Aug 2006Otsuka Pharmaceutical Co., Ltd.Freeze-dried composition for transpulmonary administration
EP2490733A1 *13 Nov 200929 Aug 2012Marc J. SalzmanSyringe-attached topical anesthetic dispenser
WO1991007940A1 *30 Nov 199013 Jun 1991Harold B LovittSelf-contained hand-held bidet
WO2002074375A1 *19 Mar 200226 Sep 2002Aradigm CorpAerosol generation using sterile multiple dose containers
Classifications
U.S. Classification128/200.14, 604/94.1, 128/203.22, 141/27, 604/229, 128/203.21, 141/329, 141/383
International ClassificationA61M15/00, A61M15/08, A61M3/00
Cooperative ClassificationA61M2015/0036, A61M15/08, A61M3/00, A61M15/0091, A61M2202/0468, A61M15/0028, A61M2205/073
European ClassificationA61M15/08, A61M3/00, A61M15/00C
Legal Events
DateCodeEventDescription
21 Jun 1982ASAssignment
Owner name: SMITHKLINE BECKMAN CORPORATION
Free format text: CHANGE OF NAME;ASSIGNOR:SMITHKLINE CORPORATION;REEL/FRAME:004080/0769
Effective date: 19820304
Owner name: SMITHKLINE BECKMAN CORPORATION, PENNSYLVANIA