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Publication numberUS3858583 A
Publication typeGrant
Publication date7 Jan 1975
Filing date28 Jan 1974
Priority date26 Feb 1973
Also published asCA1048884A1, DE2408791A1, DE2408791C2
Publication numberUS 3858583 A, US 3858583A, US-A-3858583, US3858583 A, US3858583A
InventorsHallworth Gerald Wynn, Smith Sidney William
Original AssigneeAllen & Hanburys Ltd
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Medicament inhalation device
US 3858583 A
Abstract
An inhalation device comprises a body with a dispersion chamber. A rotor is arranged in the chamber and is caused to rotate by passage of air through the chamber. One or more air inlet apertures open into the chamber around the rotor. A mouthpiece communicates with the chamber and air from the chamber can be inhaled through this mouthpiece. A capsule-retaining pocket is arranged to receive a pierced capsule and opens into the chamber. Inhalation of air through the mouthpiece will rotate the rotor, vibrate the capsule, draw medicament from the medicament containing capsule through the chamber and out through the mouthpiece.
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Description  (OCR text may contain errors)

United States Patent [1 1 Hallworth et al.

-1 11 3,858,583 [4 st Jan.7, 1975 MEDICAMENT INHALATION DEVICE [73] Assignee: Allen & Hansburys Limited,

London, England 22 Filed: Jan. 28, 1974 21 Appl. No.: 436,993

[30] Foreign Application Priority Data 1 Feb. 26; 1973 Great Britain 9246/73 [52] U.S. Cl 128/266, 128/206, 12'8/208 [51] Int. Cl. A6lm 13/00, A6lm 15/06 [58] Field ofSearch 128/266, 206, 208

[56] v References Cited UNITED STATES PATENTS I 2,517,482 8/1950 Hall 128/206 3,507,277 4/1970 Altounyan et al. 128/208 3,635,219 l/l972 Altounyan et al. 128/266 3,669,113 6/1972 Altounyan et al. 128/266 3,807,400 4/1974- Cocozza 128/266 Primary Examiner-Aldrich F. Medbery Attorney, Agent, or Firm-William R. Liberman [57] ABSTRACT An inhalation device comprises a body with a dispersion chamber. A rotor is arranged in the chamber and is caused to rotate by passage of air through the chamber. One or more air inlet apertures open into the chamber around the rotor. A mouthpiece communicates with the chamber and airfrom the chamber can be inhaled through this mouthpiece. A capsuleretaining pocket is arranged to receive .a pierced capsule and opens into the chamber. Inhalation of air through the mouthpiece will rotate the rotor, vibrate the capsule, draw medicament from the medicament containing capsule through the chamber and out through the mouthpiece.

5 Claims,,5 Drawing Figures MEDICAMENT INHALATION DEVICE BACKGROUND OF THE INVENTION It is well known to administer powdered medicament to the lung bronchioles of a patient by means of inhalation devices having mouthpieces which enable themedicament to be inhaled through the mouth of the patient. The medicament is supplied in capsules which are inserted in the device and pierced prior to use after which inhalation through the mouthpiece will cause the powdered medicament to be released from the capsule and to pass to the patient. An object of the present invention is to provide an improved such inhalation device which has a low resistance to air flow and an ability to discharge the contents of the capsule which makes it particularly suitable for use in the treatment of asthmatic patients.

BRIEF SUMMARY OF THE INVENTION According to the present invention, an inhalation device comprises a body with a dispersion chamber therein, a rotor which is rotatable in the chamber by passage of air therethrough, one or more air inlet apertures in the body, the said apertures opening into the chamber around the rotor, a mouthpiece through which air from the chamber can be inhaled, and a capsule retaining pocket arranged to receive a pierced capsule and opening into the chamber whereby inhalation of air through the mouthpiece will draw medicament from the capsule, through the chamber and out through the mouthpiece and will at the same time rotate the rotor. Preferably, the rotor is arranged to brush the end of a capsule in the capsule-retaining pocket as the rotor rotates. This causes the capsule to vibrate. Such vibration of the capsule makes it possible to empty capsules containing cohesive powders and to dispense them satisfactorily, but is not necessary with capsules charged with easily dispersible powders.

BRIEF DESCRIPTION OF ACCOMPANYING DRAWINGS FIG. 1 is a longitudinal sectional view of an inhalation device according to the invention FIG. 2 is an end elevation,

FIG. 3 is an elevation of the opposite end,

FIG. 4 is a transverse section on line X-X of FIG. 1, and

FIG. 5 is a detail view of a rotor,

DESCRIPTION OF PREFERRED EMBODIMENTS In the illustrated embodiment of the invention, an inhalation device comprises a cylindrical body 1 with a cylindrical dispersion chamber 2 therein. The chamber 2 is closed at one end by an end wall 3 and a mouthpiece 4 is fitted to the body at the other end of the chamber. A rotor 5 is arranged inside the dispersion chamber 2. This rotor 5 is a free-running multi-bladed wheel mounted on a central spindle 6 running axially of the cylindrical chamber. The rotor illustrated has two blades extending radially outwards from the central spindle sleeve 7. Any number of blades can be used, though two to four blades are preferred. The blades can be set at any desired angle and/or can be curved. The rotor must be light in weight and is. for example. of plastics material. The spindle sleeve 7 must he a close fit on the spindle 6 and the rotor is rotatable about the spindle.

One end of the spindle 6 is mounted in a cross-bar 8 extending across the mouthpiece 4. The rotor islocated at the opposite end by means of an end stop plug 9 which is firmly fixed in the spindle sleeve 7. A pointed end of the spindle 6 bears against the internal end of the plug 9. This arrangement prevents axial displacement of the rotor 5. Powder cannot enter the spindle sleeve 7.

One or more air inlet apertures 10 extend through the cylindrical body 1 and open into the dispersion chamber 2. These apertures 10 are in the form of slots which run lengthwise of the body' and are disposed at an angle which is conveniently tangential to the rotor.

The body is also provided with a capsule-retaining pocket 11..This pocket 11 is arranged at or near the closed end 3 of the dispersion chamber and has an opening leading into a recess 12 in the end wall 3 of the dispersion chamber. The pocket is arranged to receive a hard gelatine capsule 13 containing a powdered medicament.

The rotor 5 is so positioned with respect to its spindle 6 and the end wall 3 that it brushes lightly against the end of the capsule l3 protruding from the recess 12. The rotation of the rotor therefore causes the capsule 13 to vibrate and this assists in the emptying of cohesive powders from the capsule and the dispersion of such powders. If the device is intended for use with only capsules containing easily dispensible powders it is not necessary to arrange for the rotor to brush the capsules.

The body is provided at one end with a piercing needle 14 for piercing the ends of the capsule 13. This needle 14 is located in a capsule piercing pocket 15 in the end wall 3 of'the body. The capsule 15 can then be inserted into the pocket 15 and pressed against the pointed end of the needle 14, to pierce the capsule and can then be placed in the capsule-retaining pocket 11. A stirrup securing means is hingedly mounted on the body 1 and can, as shown in FIG. 1 be swung to and from a position in which it extends across the open end of the capsule and retaining pocket 11 to secure and prevent egress of the capsule.

It has been found that powder dispersion is improved by providing one of the blades of the rotor with a cut away 17 to provide unbalance and vibration to the rotor. The end of the rotor which brushes against the capsule is preferably provided with a bevel 18.

The device is, except for the spindle 6 and needle 14 made of plastics material, preferably one which has a high resistance to the build up of static electricity.

In use, a capsule 13 is pierced at both ends by means of needle 14 and is then fitted in the pocket 11. The patient then applies the mouthpiece 4 to the mouth and draws in air through the mouthpiece. The greater part of the inhaled air will enter the chamber through the tangential slots 10 and this will cause the rotor 5 to rotate rapidly. However, a portion of the inhaled air is drawn into the chamber 2 through the capsule 13 and this causes the rapid emptying of the powdered medicament into the dispersion chamber 2. The rotation of the rotor S and the turbulent air flow within the dispersion chamber 2 will cause the efficient dispersion of the powdered medicament into the air being inhaled by the patient.

With this device there is provided an excellent deep lung and upper lung penetration of the drug. The resistance to air flow can be low, for example at 2.5 cm.

water gauge at 60l/min air flow. The vibration set up by the brushing of the rotor bevel against the capsule assists in the dispersion of the powder prior to the emptying of the capsule. If a freerer flowing powder is used the brushing arrangement may be dispensed with and the unbalanced rotor would then assist in the emptying of the capsule.

What is claimed is:

1. A medicament inhalation device comprising a body with a dispersion chamber therein, a rotor mounted in one end of said chamber and which is rotatable in the chamber by passage of air there through, at least one air inlet aperture in the body, the said apertures opening into the chamber around the rotor, a mouthpiece on one end of the body through which air from the chamber can be inhaled, and a capsuleretaining pocket in and adjacent the other end of said body and in proximinity to said rotors other end to receive a pierced medicament containing capsule and opening into the chamber, a means for providing vibration and passage of medicament from said capsule comprising a capsule contacting means on the other end of said rotor whereby inhalation of air through the mouthpiece will turn said rotor to vibrate and draw medicament from the capsule through the chamber and out through the mouthpiece into the patient.

2. A device as claimed in claim 1, wherein the body has a capsule-piercing pocket in which a capsule can be removably inserted and pressed against a point in the pocket thereby to pierce the capsule.

3. A device as claimed in claim 2, wherein the rotor is mounted on a spindle carried by a cross-bar extending across the mouthpiece and said capsule contacting means is a bevel on one and of said rotor.

4. A device as claimed in claim 3, wherein the capsule retaining pocket is arranged so that one end of a capsule located therein extends into the dispersion chamber and the rotor is so positioned as to brush against the protruding end of the capsule as it rotates.

5. A device as claimed in claim 1, wherein the rotor includes two blades extending radially and oppositely outwards from a spindle sleeve, one of the said blades having a cut-away portion to provide an unbalance condition for vibration.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2517482 *9 Apr 19491 Aug 1950Sharp & Dohme IncInhaler
US3507277 *15 Sep 196721 Apr 1970Fisons Pharmaceuticals LtdInhalation device
US3635219 *4 Jun 196918 Jan 1972Fisons Pharmaceuticals LtdInhalation device
US3669113 *18 Jun 196913 Jun 1972England Eunice Cockburn HowellInhalation device
US3807400 *26 Jun 197230 Apr 1974Isf SpaInhaling device for medicinal powder compositions
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3938516 *13 Jan 197517 Feb 1976Syntex Puerto Rico, Inc.Inhalation device
US3964483 *13 Jan 197522 Jun 1976Syntex Puerto Rico, Inc.Inhalation device
US3973566 *13 Jan 197510 Aug 1976Syntex Puerto Rico Inc.Inhalation device
US4005711 *13 Jan 19751 Feb 1977Syntex Puerto Rico, Inc.Inhalation device
US4014336 *20 Nov 197529 Mar 1977Syntex Puerto Rico, Inc.Inhalation device
US4192309 *5 Sep 197811 Mar 1980Syntex Puerto Rico, Inc.Inhalation device with capsule opener
US4620847 *6 May 19844 Nov 1986Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh PolimerovDevice for administering powdered substances
US4645487 *5 Jun 198424 Feb 1987Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh PolimerovDevice for administering powdered substances
US4860740 *10 Feb 198729 Aug 1989Riker Laboratories, Inc.Powder inhalation device
US5161524 *2 Aug 199110 Nov 1992Glaxo Inc.Dosage inhalator with air flow velocity regulating means
US5372128 *14 Apr 199313 Dec 1994Habley Medical Technology CorporationFluidizing powder inhaler
US5388572 *26 Oct 199314 Feb 1995Tenax Corporation (A Connecticut Corp.)Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573 *2 Dec 199314 Feb 1995Tenax CorporationDry powder inhalator medicament carrier
US5460173 *25 Mar 199424 Oct 1995Tenax CorporationDry powder inhaler medicament carrier
US6098618 *13 Mar 19988 Aug 2000Astra AktiebolagInhalation device
US625723213 Mar 199810 Jul 2001Astra AkteibolagInhalation device
US665538013 Mar 19982 Dec 2003Astrazeneca AbInhalation device
US7228860 *9 May 200512 Jun 2007Astrazeneca AbInhaler with vibrational powder dislodgement
US777983615 Nov 200724 Aug 2010Astrazeneca AbInhalation device
US7841340 *29 Sep 200330 Nov 2010Astrazeneca AbInhaler with powder dislodging member
US81277636 Oct 20086 Mar 2012Stc.UnmDry powder inhaler with aeroelastic dispersion mechanism
US85616097 Dec 201122 Oct 2013Respira Therapeutics, Inc.Dry powder inhaler
US865110411 May 201218 Feb 2014Respira Therapeutics, Inc.Bead-containing dry powder inhaler
EP1293225A2 *13 Sep 200219 Mar 2003Omron CorporationDry powder inhaler
WO1998041264A1 *13 Mar 199824 Sep 1998Astra AbInhalation device
WO2006033584A1 *8 Sep 200530 Mar 2006Glaxosmithkline PharmaceuticalPowder inhaler
WO2006075184A1 *16 Jan 200620 Jul 2006Britannia Pharmaceuticals LtdApparatus and methods for providing dry powder medicament for inhalation
Classifications
U.S. Classification128/203.15
International ClassificationA61M15/00, A61M13/00
Cooperative ClassificationA61M2015/0033, A61M15/0028, A61M2202/064, A61M2015/0008
European ClassificationA61M15/00C