Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS3438549 A
Publication typeGrant
Publication date15 Apr 1969
Filing date29 Sep 1967
Priority date29 Sep 1967
Publication numberUS 3438549 A, US 3438549A, US-A-3438549, US3438549 A, US3438549A
InventorsRitz Alvin H
Original AssigneeBaxter Laboratories Inc
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Pre-filled syringe
US 3438549 A
Abstract  available in
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

A. H. RITZ April 15, 1969 PRE-FILLED SYRINGE sheet @f2 Filed sept. 29, 19e? fNvsN-ron ALVIN H. RITZ Flc-3.2


April 15, 1969 A. H. RITZ PRE-FILLED SYBINGE Z of' 2 Sheet Filed Sept. 29, 1967 R oz w NR E vH kizf. NN I l V L A by: ATTY United States Patent 3,438,549 PRE-FILLED SYRINGE Alvin H. Ritz, Deerfield, Ill., assignor to Baxter Iahoratories, Inc., Morton Grove, Ill., a corporation 0f Delaware Filed Sept. 29, 1967, Ser. No. 671,677 Int. Cl. B67b 7/24; Alm 5/00 ABSTRACT OF THE DISCLOSURE An ampule which is part of a piston-like assembly in said syringe, detines a liquid chamber having an inner end wall which, while in one angular aspect, is punctured by a needle to discharge liquid from said chamber upon ampule movement into the barrel from an extended position. A pouch which is associated with the piston-like assembly and isolated from said chamber, is arranged to receive the needle and prevent puncturing of the inner end wall when the ampule is moved into the barrel provided the piston is disposed in another angular aspect.

The present invention relates to a syringe. More particularly the invention relates to a syringe of the class having a barrel for receiving a reciprocative ampule with a self-sealing end wall adapted to be breached in the syringe barrel for delivering ampule contained liquid.

A syringe of the class comprehended by the invention has a hypodermic needle which extends outwardly from one end of its barrel for delivery of the uid within its ampule. A pointed member for puncturing the self-sealing nend wall of the ampule projects into the syringe barrel and may be fashioned integrally with the hypodermic needle whereupon movement of the ampule from an extended position into the syringe barrel, the pointed member breaches the self-sealing end wall for removing uids from the ampule. The conventional arrange-ment of a syringe is such that its ampule must be disposed in an extended aspect to prevent puncturing of its self-sealing end wall. This requirement producesv a cost element in syringe handling, packaging, shipping, and storage which may translate to a signifcant sum if syringes are disposable and aseptically packaged at their source according to customary practice.

It is an object of the present invention to provide an improved syringe of the indicated class.

It is a further object of the invention to preclude the requirement for extending the ampule from the barrel of said syringe when it is not in use.

It is another object of the invention to minimize the cost of handling, packaging, shipping, and storing said syringe.

The features of the invention for achieving the foregoing objects are embodied in a syringe having a barrel with an open end and a iluid delivery outlet disposed opposite said open end. A first chamber in which an ampule is disposed as a piston is defined by said barrel. The ampule is arranged for reciprocation axially of the chamber through said open end between an extended position and an inserted position, and said ampule deiines a second chamber. Means are provided for releasing liquid from said second chamber as said ampule is moved between said extended and said inserted position and while arranged at one angular aspect. However, means are provided or preventing liquid iiow from said ampule while it is disposed within the barrel of the syringe at another angular aspect.

The foregoing and other objects, features and advantages of the invention will become more apparent upon consideration of the following description and appended 3,438,549 Patented Apr. 15, 1969 ICC claims, when considered in conjunction with the accompanying drawings wherein the same reference character or numeral refers to like or corresponding parts throughout the several views.

On the drawings:

FIG. 1 is longitudinal sectional view of a syringe ernbodying one form of the invention and showing an ampule in a rst angular aspect in fully inserted position within the barrel of the syringe.

FIG. 2 is a longitudinal sectional view according to line 2-2 of FIG. l but showing the ampule in a second angular aspect and in an extended position.

FIG. 3 is a view of the barrel similar to FIG. 2 but with a needle cover removed and showing the ampule disposed between said extended and fully inserted positions and in the same angular aspect as FIG. 1.

FIG. 4 is a cross sectional View according to the line 4-4 of FIG. 1.

FIG. 5 is a cross sectional view according to the line 5-5 of FIG. 1.

FIG. 6 is a cross sectional View according to the line 6-6 of FIG. 1.

Referring now more particularly to the drawings, there is shown a syringe comprised of a syringe barrel 10 defining therein a chamber 16 and having an upper opening 12 and a lower outlet portion 14. Barrel 10 may be of glass or rigid plastic fabrication and fashioned with a pair of oppositely extending iinger-gripping wings 18 adapted to be engaged from beneath by index and second iingers of a hand when the syringe is used. A hollow hypodermic needle 20, which is in uid communication with chamber 16, is mounted and projects outwardly from the outlet end portion 14 of syringe barrel 10; and a removable needle cover 21 encloses the outwardly projecting part of needle 20 in an air tight seal.

A reciprocative assembly 23 which is movable in and out of barrel 10 through opening 12 comprises an elongated cage or frame 25 having an inner rupturable or breachable self-sealing membrane 26 which forms a floor for said cage. In the present embodiment membrane 26 is poportioncd as a piston for snug and sliding tit within barrel 10 so that upon extension of cage 25 from barrel 10 a partial vacuum will be drawn in chamber 16. An ampule 22 comprises container means which is, but need not be, of collapsible and plastic fabrication and defines a second chamber 24 for liuid 27. Ampule 22 is disposed in cage 25 and is breachably sealed by securance to membrane 26 which forms an inner end wall for said ampule so that it may be moved with reciprocative assembly 23 between a irst position in which said reciprocative assembly is extended through opening 12 (FIG. 2) so that membrane 26 cannot be breached at any angular aspect and a second position in which said ampule is inserted in said barrel (FIGS. 1 and 3) suiiiciently for breaching membrane 26 in a manner to become apparent from the ensuing description.

For removing liquid 27 from chamber 24, breaching means, comprising a hollow pointed or puncturing member 28 projects into chamber 16 from the bottom 30 on syringe barrel 10. Although puncturing member 28 is shown fashioned integrally vwith needle 20, it need not be. The length of the puncturing member is such that when ampule 22 is disposed in its iirst position, the scalable membrane 26 cannot be breached under any circumstances. Whereas, when said ampule is disposed between its second or inserted position and said first position, membrane 26 will be breached provided said ampule is disposed at a proper angular aspect, as will be hereinafter explained. Puncturing member 28 has an aperture 31 for delivering liquid from `chamber 24 through the wall of the puncturing member to chamber 16 once membrane 26 has been breached. An axially elongated groove or pouch 35 which is isolated from chamber 24 is formed in the lower end portion of reciprocative assembly 23'. An exterior key, or spline 36 (FIGS. 3 and 4) which is fashioned on reciprocative assembly 23` is adapted for snug sliding engagement in an upwardly opening outwardly extending keyway or pocket 37, formed in barrel 10, when ampule 22 is disposed in a first angular aspect (FIGS. l and 3) and enables reciprocation of ampule 22 from an extended to a fully inserted position relative said barrel. Pouch 35 is proportioned for reception of and receives puncturing member 28 when ampule 22 is in its fully inserted position and thereby precludes breaching membrane 26 by puncturing member 28. The foregoing feature permits reciprocative assembly 23 to be stored in a fully inserted position within the barrel during handling, packaging, and subsequent storage.

Removal of liquid 27 from chamber 24 can occur only when ampule 22 is disposed in a second angular aspect, that is when puncturing member 28 has a relative angular attitude (FIG. 2) in which is will breach membrane 26 upon partial insertion of ampule 22 into barrel 10. Accordingly then, spline 36 will not be engaged in or aligned with pocket 37. It is appreciated that insertion of ampule 22 into barrel 10, while said ampule is in its second aspect, will be limited by engagement of the lower end of said spline 36 with the upper end of said barrel. However, puncturing member 28 is proportioned so that, notwithstanding such limitation membrane 26 can be punctured.

|Flow from chamber 24 into chamber 16 through aperture 31 will be facilitated by the partial vacuum which has been drawn in chamber 1-6, as aforesaid. Removal of fluid from the syringe, that is chamber 16, however, requires that reciprocative assembly 23 be disposed in its first angular aspect for reinsertion into the barrel beyond the limited condition of insertion possible While said assembly is disposed in its second angular aspect. With reciprocative assembly 23 disposed in said first angular aspect it may be wholly inserted in barrel 10 to force any liquid then in chamber 16 through aperture 31 out of said last chamber through needle 20= provided needle cover 21 has been removed as in FIG. 3.

As many substitutions or changes could be made in the above described construction, and as many apparently widely different embodiments of the invention Within the scope of the claims could be constructed Without departing from the scope and spirit thereof, it is intended that all matter `contained in the accompanying specification shall be interpreted as being illustrative and not in a limiting sense.

What is claimed is:

1. In a syringe having a barrel with a liquid delivery end and an open end, the combination of: an ampule having a chamber for storage of liquid and a breachable end wall for sealing said chamber, said ampule mounted for selective reciprocation in said barrel between an extended position and an inserted position, and for selective rotation in said barrel between a rst angular aspect and a second angular aspect when in said extended position; eccentrically mounted wall breaching means within said barrel for discharging liquid from said chamber as said ampule, while disposed in said second aspect, is moved between said extended position and said inserted position, and a correspondingly eccentrically mounted pouch isolated from said chamber and for reception of said -wall breaching means while said ampule is disposed in said rst aspect in said inserted position to prevent breach of said wall.

2. The combination of claim 1 further characterized by means for reciprocatively and releasably locking said ampule in said first angular aspect.

3'. The combination of claim 2 in which said means comprises an axially extending spline and means for releasably holding said spline in said first angular aspect, said spline and releasable holding means associated with said ampule and barrel.

4. In a syringe the combination of: a barrel having an open end, a fluid delivery outlet disposed opposite said open end and a iirst chamber; an assembly including container means having a second chamber and arranged in said `first chamber for reciprocation axially thereof through said open end between an extended and an inserted position, and a hollow member fixed relative said barrel for puncturing said container means to establish liquid communication between said -rst and second chambers as said assembly is moved between said extended and said inserted position, said container means having a pocket for receiving said hollow member as said assembly is moved between said viirst and second position to prevent puncturing said ampule and arranged for angular rotation between first and second aspects in which said hollow member is, respectively, aligned for reception in said pocket and puncturing said container means.

References Cited UNITED STATES PATENTS 2,733,836- 2/ 1956 Switzer 222-82 3,108,591 10/1963` Kolbas 12S-218 3,115,875 12/1963 Wilburn 128--218 SAMUEL F. COLEMAN, Primary Examiner.

U.S. C1. X.R.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2733836 *7 Oct 19527 Feb 1956 Perforator and container for packaged grease
US3108591 *29 May 196229 Oct 1963Bristol Mycrs CompanySyringe
US3115875 *14 Nov 196031 Dec 1963Edgar H WilburnCartridge syringes
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4177938 *30 Jun 197711 Dec 1979Brina Guido JContainer with mixing cartridge
US4801047 *10 Aug 198731 Jan 1989E. R. Squibb & Sons, Inc.Dispensing device for radionuclide generators
US5163582 *30 Sep 199117 Nov 1992Andronic Devices Ltd.Apparatus and method for aliquotting blood serum or blood plasma
US5413246 *5 May 19939 May 1995Automed CorporationApparatus and method for aliquotting phases of blood
US5555920 *3 Sep 199317 Sep 1996Automed CorporationMethod and apparatus for aliquotting blood serum or blood plasma
US6464105 *10 Aug 200015 Oct 2002Transcoject Gesellschaft für medizinische Geräte mbH & Co. KGDevice for withdrawing a ready liquid medicament from a receptacle provided with a pierceable membrane
US713796720 Oct 200321 Nov 2006Nemoto Kyorindo Co., Ltd.Cylinder holder for a syringe barrel
US726461222 Oct 20034 Sep 2007Nemoto Kyorindo Co., Ltd.Syringe barrel with guide
US734452023 Oct 200318 Mar 2008Nemoto Kyorindo Co LtdSyringe barrel with reinforcing rib
US7393341 *22 Oct 20031 Jul 2008Shigeru NemotoCylinder holder for a syringe barrel with rear surface projection
US769545723 Oct 200313 Apr 2010Nemoto Kyorindo Co., Ltd.Syringe barrel with roughened surface
US779443530 Jan 200814 Sep 2010Shigeru NemotoSyringe barrel with reinforcing rib
US787500530 Jan 200825 Jan 2011Nemoto Kyorindo Co., Ltd.Syringe barrel with reinforcing rib
US8132958 *12 Dec 200713 Mar 2012Renfro Charles KMulti-chambered fluid mixing apparatus and method
US20040082919 *22 Oct 200329 Apr 2004Shigeru NemotoCylinder holder for a syringe barrel with rear surface projection
US20040087908 *20 Oct 20036 May 2004Shigeru NemotoCylinder holder for a syringe barrel
US20040087909 *23 Oct 20036 May 2004Shigeru NemotoSyringe barrel with reinforcing rib
US20040087910 *23 Oct 20036 May 2004Shigeru NemotoSyringe barrel with roughened surface
US20040092881 *22 Oct 200313 May 2004Shigeru NemotoSyringe barrel with guide
US20080132853 *30 Jan 20085 Jun 2008Shigeru NemotoSyringe Barrel With Reinforcing Rib
US20080144433 *12 Dec 200719 Jun 2008Renfro Charles KMulti-chambered fluid mixing apparatus and method
WO1990011790A1 *3 Apr 199018 Oct 1990Keith Herd Youne McmahonDisposable syringe
U.S. Classification222/83.5, 604/226, 604/203, 604/192
International ClassificationA61M5/24
Cooperative ClassificationA61M5/24
European ClassificationA61M5/24