Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3125096 A
Publication typeGrant
Publication date17 Mar 1964
Filing date7 Jul 1961
Publication numberUS 3125096 A, US 3125096A, US-A-3125096, US3125096 A, US3125096A
InventorsLeonard Antilcs
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Compressor
US 3125096 A
Abstract  available in
Images(1)
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

Filed July '7, 1961 COMPRESSOR PUMP COUPLING 35 THERMOMETER 5 m m 0mm N A MN M H W n f m 1%,. .0 3 M 3 mm x a Y w B T M S United States Patent Office 1 3,125,096 Patented Mar. 17,, 1964 3,125,096 BODY COGLING APPARATUS Leonard Antiles, Albany, and Norman C. Jeckel, Glens Falls, N.Y., assignors to United States Catheter & In-

strument Corporation, Glens Falls, N.Y., a corporation of New York Filed July 7, 1961, Ser. No. 122,507 3 Claims. (Cl. 128-401) This invention relates to new and useful improvements for cooling a part or all of the body of a warm blooded animal and is more particularly concerned with a simple unit that provides refrigeration at the specific body site where cooling is desired, i.e., permits a liquid refrigerant to evaporate at the desired body site to obtain direct, quick, simple and efficient cooling.

Much attention has been given recently to cooling the entire body (for certain types of surgery) or a portion of the body for local surgery or to relieve certain conditions, e.g., stomach hemorrhages caused by perforated or bleeding ulcers.

For cooling the entire body external ice baths are generally used which is shocking to the body and inefficient as the surface blood circulation is automatically reduced to thus set up an insulation barrier between the cooling bath and the internal organs and blood supply.

For cooling a specific body organ such as the stomach internally, cold Water way be introduced into the stomach through a Levin tube in an emergency, or a more expensive device permits the circulation of cold brine through tubes placed in the stomach.

The latter unit is quite expensive and thus not available in many hospitals and, moreover, takes more than an hour to get started as the brine must first be cooled to the necessary temperature. Furthermore, it takes extensive tubing within the stomach to have a large heat exchange surface and the response of the unit to controls is not very sensitive. The cold water technique is crude, shocking and, at best, considered only as an emergency measure.

Therefore, it is an object of this invention to provide a simple, direct and efficient method of cooling all or parts of the body where the cooling action of a conventional refrigerant is applied directly to the body member.

It is a further object of this invention to be able to start cooling the desired body member almost immediately after demand.

It is an additional object of this invention to provide a cooling :method for reducing the temperature of the entire body by application of heat exchange to internal organs rather than to the outer body surface.

We have found that a conventional refrigerant may be cycled in a controlled manner whereby the evaporating and cooling cycle is performed in contact with a body member to be cooled so as to quickly, efficiently and simply cool said member to the degree desired.

This is particularly applicable to the internal stomach where quick, effective and controlled measures are often desirable in dealing with hemorrhages caused by ulcers. It further permits efficient cooling as more intimate exchange is made with greater amounts of the blood supply which is the heat carrier of the body.

With these and other objects and features in view, the nature of which will be more apparent, the invention will be more clearly understood by reference to the drawings, the accompanying detailed description and the appended claims.

In the drawings:

FIG. 1 is a diagrammatic section of a gastric cooling apparatus constructed in accordance with this invention; and

FIG. 2 is a section taken on line 22 of FIG. 1.

This invention as illustrated is embodied in a refrigeration unit especially adapted for cooling the stomach and includes a portion that rests inside the stomach, a long tube to reach the stomach through the esophagus and nasal passages or mouth, and an exterior control unit for circulating, compressing and controlling the amount of refrigerant.

A balloon 5 in a deflated state, as shown in dotted lines along with the esophageal tube 7, is swallowed through the oral cavity, fed through the nostrils, or otherwise placed into the stomach by conventional means. The balloon is made of any thin, non-toxic, non-irritating material, e.g., vinyl plastic and the tube is made of any conventional catheter material such as rubber or plastic with a radioopaque material coated or impregnated thereto. The tube 7 has suificient length to reach from the stomach through the esophagus to a point outside the patients month where the tube is divided into four sub tubes (non-radioopaque), namely, a gas-refrigerant return tube 9, a pressure monitoring tube 11, a liquidrefrigerant feed tube 13, and a Levin tube 15. These four tubes have separate and independent bores (see FIG. 2) through the esophageal tube 7 into the balloon 5.

The Levin tube 15 is. connected at its outer end with a pump 17 and has an opening 19 at its other end outside the balloon 5 at the extreme end of the unit and thus may be used to pump material in or out of the stomach cavity in a conventional manner.

A reservoir 21 contains a non-toxic refrigerant e.g., an inert material such as Freon C-318 (octafluorocyclobutane) or Freon l2 (dichlorodifluoromethane) at room temperature, which will thus exert from about 12 to 15 pounds {per square inch pressure. Tube 13 is connected at its outer end to the reservoir 21 and carries a valve 23 which controls the flow of refrigerant through the tube. "ube 13 is provided at its inner end with a plurality of small orifices 25 through which the refrigerant sprays into the balloon 5 thereby inflating the balloon against the stomach wall as it sprays and simultaneously evaporates to create a cooling action throughout the balloon. The pressure should be maintained at a comfortable level for the patient which is up to about 16 ounces per square inch with the preferred range being about 1 to 6 ounces.

The pressure in the balloon is communicated, through openings 27 and the pressure monitoring tube 11, to a coupling 29 provided with a sensitive diaphragm 31 so arranged that only a minimum volume of refrigerant is involved whereas the major volume in the coupling is on the opposed side of the diaphragm and may be occupied by air or other cheap fluid. The opposed side of the diaphragm is connected to a pressure responsive solenoid switch 33 which is connected to and controls valve 23 to maintain the desired pressure in the balloon.

The gas refrigerant in balloon 5 is withdrawn through openings 34 and tube 9 past thermometer 35 positioned immediately outside the patient where the temperature has been found to be close to that 'within the balloon. The gas is withdrawn by the compressor 37 which includes a radiator cooling unit to cool the liquid refrigerant to room temperature after compression and prior to storage in the reservoir 21.

All the apparatus shown here outside the patient, i.e. pump 17, coupling 29, switch 33, valve 23, thermometer 35,.compressor 37 and reservoir 21 will be conveniently mounted as a single unit on a stand with provision for detachably securing the subtubes 9, 11, 13 and 15. As a rule, there will be several tubular-balloon units for every stand unit as the tubular-balloon units should be washed and sanitized after each use.

The specific apparatus described herein is adapted particularly for direct contact with the stomach but a similar balloon may be placed in other body cavities such as the rectum, abdomen and chest or Wrapped around body members such as the arms or legs to secure direct contact for efiicient cooling. The cooling effect may be local as desired for gastric hemorrhages or suflicient to cool the entire body as for heart surgery. The whole body can readily be cooled from internal sites such as the stomach or rectum.

Using Freon C-3'l8 at about 1 to 4 ounces per square inch pressure within the balloon We have found the temperature in the balloon to be about 30 F. and about 32 F. at the thermometer 35. Patients with bleeding or perforated ulcers, who have been acutely ill and in great pain, have beengreatly improved by use of the device at these levels for from 15 to 600' minutes, the cooling action starting within minutes of decision to use the unit and the improvement in the patients being noted within 10 to 60 minutes.

The unit is also excellent for inducing general hypothermia quickly, efficiently and without shivering by the patient. One patient, with the balloon positioned Within the stomach, had his temperature reduced from about 98 -F. to about 86 F. over a period of 2%. hours.

We claim:

1. A body cavity cooling device comprising a thinwalled inflatable container adapted to be positioned within said cavity and capable of lining the boundary wall of said cavity, an elongated member extending through and leading from one end of said container and adapted to reach from said cavity through a natural channel to the v exterior of said body, a feed tube extending through said elongated member terminating at a plurality of small orifices in said container adapted for spraying :a liquid refrigerant, a withdrawal tube extending through said elongated member terminating in an opening in said container adapted to withdraw gaseous refrigerant therefrom, and a monitoring tube extending through said elongated member terminating in an aperture in said container adapted to communicate the pressure in said container to the exterior of said body.

2. The cooling device of'claim l which additionally comprises an access tube extending through said elongated member and terminating in a hole outside said container near the end opposed to said one end of said container.

3. An animal stomach cooling device comprising a thin- Walled inflatable container adapted to be positioned within said stomach and capable of lining the boundary wall of said stomach, an elongated member extending through and leading from one end of said container and adapted to reach from said stomach through the esophagus to the exterior of said animal, a feed tube extending through said elongated member terminating at a plurality of small orifices in said container adapted for spraying a liquid refrigerant, a withdrawal tube extending through said elongated member terminating in an opening in said container adapted to withdraw gaseous refrigenant therefrom, a monitoring tube extending through said elongated mem ber terminating in an aperture in said container adapted to communicate the pressure in said container to the exterior of said animal, means to force refrigerant through said feed tube and orifices whereby said refrigerant evaporates in said container, means to withdraw said evaporated refrigerant through said withdrawal tube, means to compress and cool said evaporated refrigerant to the liquid state, and means to recirculate said compressed and cooled refrigenant at a rate to maintain a pressure in said container.

References Cited in the file of this patent UNITED STATES PATENTS 2,190,383 Newman Feb. 13, 1940 2,190,384 Newman Feb. 13, 1940 2,493,759 Freygang Jan. 10, 1950

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2190383 *29 Aug 193613 Feb 1940Newman Louis BTherapeutic apparatus
US2190384 *6 Jul 193713 Feb 1940Newman Louis BTherapeutic bag
US2493759 *28 Nov 194410 Jan 1950Kidde Mfg Co IncProduction of carbon dioxide snow
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3238944 *8 Oct 19628 Mar 1966Max L HirschhornTemperature controlling device for living organs
US3254652 *15 Mar 19637 Jun 1966Affiliated Hospital ProdMeans and methods for producing gastric hypothermia
US3298371 *11 Feb 196517 Jan 1967Arnold S J LeeFreezing probe for the treatment of tissue, especially in neurosurgery
US3302634 *13 Sep 19637 Feb 1967Mazellan Myron WInflatable string for marking internal bleeding
US3421508 *31 Aug 196614 Jan 1969Union Mfg CoCryosurgical probe
US3460538 *20 Oct 196712 Aug 1969Edward T ArmstrongHypothermia apparatus and method for treating the human body and the like
US4190033 *21 Jul 197826 Feb 1980Foti Thomas MClosed flow caloric test method
US4299237 *27 Jun 197910 Nov 1981Foti Thomas MClosed flow caloric test device
US4619257 *30 Nov 198428 Oct 1986Board Of Regents, The University Of Texas SystemApparatus and method for cryopreparing corneal tissue for surgical procedures
US4662383 *23 Sep 19835 May 1987Kureha Kagaku Kogyo Kabushiki KaishaEndotract antenna device for hyperthermia
US4676258 *5 Jun 198630 Jun 1987Kureha Kagaku Kogyo Kabushiki KaishaDevice for hyperthermia
US5044165 *15 Dec 19883 Sep 1991Board Of Regents, The University Of TexasCryo-slammer
US5330518 *6 Mar 199219 Jul 1994Urologix, Inc.Method for treating interstitial tissue associated with microwave thermal therapy
US5413588 *6 Mar 19929 May 1995Urologix, Inc.Device and method for asymmetrical thermal therapy with helical dipole microwave antenna
US5437673 *4 Feb 19931 Aug 1995Cryomedical Sciences, Inc.Closed circulation tissue warming apparatus and method of using the same in prostate surgery
US5464445 *9 Mar 19947 Nov 1995Urologix, Inc.Device and method for asymmetrical thermal therapy with helical dipole microwave antenna
US5501681 *12 Nov 199326 Mar 1996Neuwirth; Robert S.Intrauterine cryoablation cauterizing apparatus and method
US5545137 *30 Mar 199513 Aug 1996Urologix, Inc.Device for asymmetrical thermal therapy with helical dipole microwave antenna
US5620480 *20 Sep 199415 Apr 1997Urologix, Inc.Method for treating benign prostatic hyperplasia with thermal therapy
US5628770 *6 Jun 199513 May 1997Urologix, Inc.Devices for transurethral thermal therapy
US5645528 *6 Jun 19958 Jul 1997Urologix, Inc.Unitary tip and balloon for transurethral catheter
US5755754 *19 Jul 199626 May 1998Urologix, Inc.Device and method for asymmetrical thermal therapy with helical dipole microwave antenna
US5755756 *15 Sep 199526 May 1998Freedman, Jr.; Robert J.Hypothermia-inducing resuscitation unit
US5807391 *23 Sep 199615 Sep 1998Cordis CorporationCryo-ablation catheter
US5843144 *26 Jun 19951 Dec 1998Urologix, Inc.Method for treating benign prostatic hyperplasia with thermal therapy
US5846235 *14 Apr 19978 Dec 1998Johns Hopkins UniversityEndoscopic cryospray device
US5861021 *20 Dec 199619 Jan 1999Urologix IncMicrowave thermal therapy of cardiac tissue
US5868735 *6 Mar 19979 Feb 1999Scimed Life Systems, Inc.Cryoplasty device and method
US5916240 *15 Jul 199729 Jun 1999Urologix, Inc.Device and method for asymmetrical thermal therapy with helical dipole microwave antenna
US5916241 *30 Jul 199729 Jun 1999Urologix, Inc.Device and method for asymmetrical thermal therapy with helical dipole microwave antenna
US6009351 *14 Jul 199728 Dec 1999Urologix, Inc.System and method for transurethral heating with rectal cooling
US6126684 *21 Apr 19983 Oct 2000The Regents Of The University Of CaliforniaIndwelling heat exchange catheter and method of using same
US6146411 *24 Dec 199814 Nov 2000Alsius CorporationCooling system for indwelling heat exchange catheter
US6165207 *27 May 199926 Dec 2000Alsius CorporationMethod of selectively shaping hollow fibers of heat exchange catheter
US62873262 Aug 199911 Sep 2001Alsius CorporationCatheter with coiled multi-lumen heat transfer extension
US629069612 Jan 199918 Sep 2001Scimed Life Systems, Inc.Cryoplasty device and method
US629959927 Oct 19999 Oct 2001Alsius CorporationDual balloon central venous line catheter temperature control system
US633872713 Aug 199815 Jan 2002Alsius CorporationIndwelling heat exchange catheter and method of using same
US6355029 *1 Dec 199812 Mar 2002Cryovascular Systems, Inc.Apparatus and method for cryogenic inhibition of hyperplasia
US63683045 May 19999 Apr 2002Alsius CorporationCentral venous catheter with heat exchange membrane
US6383181 *5 Jan 20007 May 2002Frank MajerowiczMethod and apparatus for cryogenic spray ablation of gastrointestinal mucosa
US639332024 Jul 200121 May 2002Alsius CorporationMethod for treating cardiac arrest
US641964318 Aug 199916 Jul 2002Alsius CorporationCentral venous catheter with heat exchange properties
US644747415 Sep 199910 Sep 2002Alsius CorporationAutomatic fever abatement system
US645099019 Apr 199917 Sep 2002Alsius CorporationCatheter with multiple heating/cooling fibers employing fiber spreading features
US645479225 Oct 200024 Sep 2002Alsius CorporationCooling system for indwelling heat exchange catheter
US645815011 Mar 19991 Oct 2002Alsius CorporationMethod and apparatus for patient temperature control
US6482226 *30 Aug 200019 Nov 2002Innercool Therapies, Inc.Selective organ hypothermia method and apparatus
US651424519 Jul 20004 Feb 2003Cryovascular Systems, Inc.Safety cryotherapy catheter
US651622424 Jul 20014 Feb 2003Alsius CorporationMethod for treating cardiac arrest
US65309463 Oct 200011 Mar 2003Alsius CorporationIndwelling heat exchange heat pipe catheter and method of using same
US653380411 Jan 200118 Mar 2003Innercool Therapies, Inc.Inflatable catheter for selective organ heating and cooling and method of using the same
US65372716 Jul 200025 Mar 2003Cryogen, Inc.Balloon cryogenic catheter
US65407718 Jan 20011 Apr 2003Innercool Therapies, Inc.Inflatable catheter for selective organ heating and cooling and method of using the same
US65512743 Jan 200122 Apr 2003Biosense Webster, Inc.Cryoablation catheter with an expandable cooling chamber
US655134922 Mar 200122 Apr 2003Innercool Therapies, Inc.Selective organ cooling apparatus
US655841212 Apr 20016 May 2003Innercool Therapies, Inc.Selective organ hypothermia method and apparatus
US657264021 Nov 20013 Jun 2003Alsius CorporationMethod and apparatus for cardiopulmonary bypass patient temperature control
US65760013 Dec 200110 Jun 2003Innercool Therapies, Inc.Lumen design for catheter
US65760024 Jan 200110 Jun 2003Innercool Therapies, Inc.Isolated selective organ cooling method and apparatus
US658239822 Sep 200024 Jun 2003Alsius CorporationMethod of managing patient temperature with a heat exchange catheter
US65857527 Nov 20011 Jul 2003Innercool Therapies, Inc.Fever regulation method and apparatus
US658927113 Dec 20018 Jul 2003Alsius CorporationsIndwelling heat exchange catheter
US659596716 Sep 200222 Jul 2003Innercool Therapies, Inc.Collapsible guidewire lumen
US659931229 May 200129 Jul 2003Innercool Therapies, Inc.Isolated selective organ cooling apparatus
US6602247 *12 Mar 20025 Aug 2003Cryocath Technologies Inc.Apparatus and method for performing a treatment on a selected tissue region
US66022761 Mar 20015 Aug 2003Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US662013110 Aug 200116 Sep 2003Alsius CorporationDual balloon central venous line catheter temperature control system
US664160211 Apr 20024 Nov 2003Alsius CorporationMethod and device including a colo-rectal heat exchanger
US664887825 Jul 200118 Nov 2003Scimed Life Systems, Inc.Cryoplasty device and method
US664887914 Sep 200118 Nov 2003Cryovascular Systems, Inc.Safety cryotherapy catheter
US66489065 Apr 200118 Nov 2003Innercool Therapies, Inc.Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid
US664890811 Mar 200218 Nov 2003Innercool Therapies, Inc.Inflatable catheter for selective organ heating and cooling and method of using the same
US665256524 Aug 200125 Nov 2003Alsius CorporationCentral venous catheter with heat exchange properties
US666002825 Feb 20029 Dec 2003Innercool Therapies, Inc.Method for determining the effective thermal mass of a body or organ using a cooling catheter
US66668584 May 200123 Dec 2003Scimed Life Systems, Inc.Cryo balloon for atrial ablation
US667668816 Apr 200113 Jan 2004Innercool Therapies, Inc.Method of making selective organ cooling catheter
US667668911 Mar 200213 Jan 2004Innercool Therapies, Inc.Inflatable catheter for selective organ heating and cooling and method of using the same
US667669020 Jun 200113 Jan 2004Innercool Therapies, Inc.Inflatable heat transfer apparatus
US668573217 Aug 20013 Feb 2004Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US669248812 Apr 200117 Feb 2004Innercool Therapies, Inc.Apparatus for cell necrosis
US669587311 Mar 200224 Feb 2004Innercool Therapies, Inc.Inflatable catheter for selective organ heating and cooling and method of using the same
US670284230 May 20029 Mar 2004Innercool Therapies, Inc.Selective organ cooling apparatus and method
US670943118 Dec 200123 Mar 2004Scimed Life Systems, Inc.Cryo-temperature monitoring
US671623619 Oct 20016 Apr 2004Alsius CorporationIntravascular catheter with heat exchange element having inner inflation element and methods of use
US67197236 Dec 200013 Apr 2004Innercool Therapies, Inc.Multipurpose catheter assembly
US672665319 Oct 200127 Apr 2004Alsius Corp.Indwelling heat exchange catheter and method of using same
US6726708 *14 Jun 200127 Apr 2004Innercool Therapies, Inc.Therapeutic heating and cooling via temperature management of a colon-inserted balloon
US674010916 Dec 200225 May 2004Innercool Therapies, Inc.Isolated selective organ cooling method
US675585029 May 200229 Jun 2004Innercool Therapies, Inc.Selective organ hypothermia method and apparatus
US681155011 Jul 20022 Nov 2004Cryovascular Systems, Inc.Safety cryotherapy catheter
US681801116 Feb 200116 Nov 2004Innercool Therapies, Inc.Circulating fluid hypothermia method and apparatus
US68305819 Aug 200214 Dec 2004Innercool Therspies, Inc.Method and device for patient temperature control employing optimized rewarming
US68694409 Aug 200222 Mar 2005Innercool Therapies, Inc.Method and apparatus for patient temperature control employing administration of anti-shivering agents
US6893454 *28 Apr 200317 May 2005Alsius CorporationIntrarectal heat exchange catheter
US690549428 Feb 200214 Jun 2005Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US690550918 Jul 200114 Jun 2005Innercool Therapies, Inc.Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US691892417 Nov 200319 Jul 2005Innercool Therapies, Inc.Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid
US697201523 Feb 20046 Dec 2005Cryovascular Systems, Inc.Cryosurgical fluid supply
US697934520 Jun 200227 Dec 2005Innercool Therapies, Inc.Multipurpose catheter assembly
US698900919 Apr 200224 Jan 2006Scimed Life Systems, Inc.Cryo balloon
US699164530 May 200231 Jan 2006Innercool Therapies, Inc.Patient temperature regulation method and apparatus
US70013781 Mar 200221 Feb 2006Innercool Therapies, Inc.Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US701839929 Dec 200328 Mar 2006Innercool Therapies, Inc.Method of making selective organ cooling catheter
US702212010 Sep 20034 Apr 2006Scimed Life Systems, Inc.Cryoplasty device and method
US705250818 Nov 200330 May 2006Innercool Therapies, Inc.Inflatable heat transfer apparatus
US70600624 Jun 200313 Jun 2006Cryo Vascular Systems, Inc.Controllable pressure cryogenic balloon treatment system and method
US70637185 Mar 200320 Jun 2006Innercool Therapies, Inc.Selective organ hypothermia method and apparatus
US70669488 Mar 200427 Jun 2006Innercool Therapies, Inc.Selective organ cooling apparatus and method
US707782516 Jan 200218 Jul 2006Radiant Medical, Inc.Method for gastric cooling using balloon catheter
US70942539 Apr 200322 Aug 2006Innercool Therapies, Inc.Fever regulation method and apparatus
US710136827 Oct 20035 Sep 2006Scimed Life Systems, Inc.Cryo balloon for atrial ablation
US710138615 Aug 20025 Sep 2006Innercool Therapies, Inc.Patient temperature regulation method and apparatus
US718922721 Mar 200513 Mar 2007Boston Scientific Scimed, Inc.Cryo balloon
US718925424 Aug 200413 Mar 2007Innercool Therapies, Inc.Method and device for patient temperature control employing optimized rewarming
US72111055 Dec 20031 May 2007Innercool Therapias, Inc.Method for determining the effective thermal mass of a body or organ using a cooling catheter
US722025725 Jul 200022 May 2007Scimed Life Systems, Inc.Cryotreatment device and method
US724365520 Sep 200517 Jul 2007Serene Medical, Inc.System and method using the rectal mucosal membrane for inducing hypothermia and warming
US727898431 Dec 20029 Oct 2007Alsius CorporationSystem and method for controlling rate of heat exchange with patient
US728808913 Jun 200530 Oct 2007Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US72911443 Jan 20026 Nov 2007Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US729414213 Aug 200213 Nov 2007Innercool TherapiesSelective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US731172525 Jan 200625 Dec 2007Innercool Therapies, Inc.Patient temperature regulation method and apparatus
US73512543 Dec 20041 Apr 2008Innercool Therapies, Inc.Method and device for patient temperature control employing optimized rewarming
US73712543 Sep 200413 May 2008Innercool Therapies, Inc.Medical procedure
US738763812 Sep 200517 Jun 2008Serene Medical, Inc.System and method using the rectal mucosal membrane for inducing hypothermia and warming
US742260021 Mar 20059 Sep 2008Innercool Therapies, Inc.Method and apparatus for patient temperature control employing administration of anti-shivering agents
US74490187 Jan 200411 Nov 2008Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US749122326 Apr 200417 Feb 2009Innercool Therapies, Inc.Therapeutic heating and cooling via temperature management of a colon-inserted balloon
US7591814 *29 Mar 200522 Sep 2009Cryocath Technologies Inc.Extended treatment zone catheter
US760463115 Dec 200420 Oct 2009Boston Scientific Scimed, Inc.Efficient controlled cryogenic fluid delivery into a balloon catheter and other treatment devices
US764163231 Aug 20075 Jan 2010Zoll Circulation, Inc.System and method for controlling rate of heat exchange with patient
US765151814 Nov 200326 Jan 2010Innercool Therapies, Inc.Inflatable catheter for selective organ heating and cooling and method of using the same
US767425617 Mar 20059 Mar 2010Boston Scientific Scimed, Inc.Treating internal body tissue
US7727228 *23 Mar 20041 Jun 2010Medtronic Cryocath LpMethod and apparatus for inflating and deflating balloon catheters
US776694916 Aug 20063 Aug 2010Innercool Therapies, Inc.Fever regulation method and apparatus
US7811313 *30 Jun 200412 Oct 2010Boston Scientific CorporationDevice for treatment of tissue adjacent a bodily conduit by thermocompression
US7833220 *19 Feb 200316 Nov 2010Boston Scientific CorporationMethod and apparatus treating tissue adjacent a bodily conduit with thermocompression and drugs
US7837720 *13 May 200323 Nov 2010Boston Scientific CorporationApparatus for treatment of tissue adjacent a bodily conduit with a gene or drug-coated compression balloon
US785068117 Feb 200614 Dec 2010Boston Scientific Scimed, Inc.Cryoplasty device and method
US78507217 May 200814 Dec 2010Serene Medical, Inc.System and method using the rectal mucosal membrane for inducing hypothermia and warming
US7857781 *16 May 200528 Dec 2010Zoll Circulation, Inc.Indwelling heat exchange catheter and method of using same
US7896009 *26 Jun 20061 Mar 2011Zoll Circulation, Inc.Method for gastric cooling using balloon catheter
US795118313 May 200831 May 2011Innercool Therapies, Inc.Medical procedure
US799818217 Jan 200616 Aug 2011Innercool Therapies, Inc.Selective organ cooling apparatus
US801214712 Apr 20076 Sep 2011Boston Scientific Scimed, Inc.Cryotreatment device and method
US80432836 Nov 200725 Oct 2011Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US804335130 Oct 200725 Oct 2011Innercool Therapies, Inc.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US808812514 Dec 20103 Jan 2012Boston Scientific Scimed, Inc.Cryoplasty device and method
US812859524 Aug 20016 Mar 2012Zoll Circulation, Inc.Method for a central venous line catheter having a temperature control system
US815779430 Oct 200717 Apr 2012Innercool Therapies, Inc.Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US816300013 Nov 200724 Apr 2012Innercool Therapies, Inc.Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US81777792 Dec 200515 May 2012Boston Scientific Scimed, Inc.Controllable pressure cryogenic balloon treatment system and method
US82214133 Aug 201017 Jul 2012Boston Scientific CorporationDevice and method for treatment of tissue adjacent a bodily conduit by thermocompression
US822141412 Oct 201017 Jul 2012Boston Scientific CorporationCatheter
US822445512 Oct 201017 Jul 2012Boston Scientific CorporationDrug delivery
US823597625 Feb 20047 Aug 2012Boston Scientific Scimed, Inc.Cryo-temperature monitoring
US83036373 Jul 20086 Nov 2012Atsuo MoriCatheter for topical cooling and topical cooling device using the same
US83337585 Jan 201018 Dec 2012Boston Scientific ScimedCryosurgical fluid supply
US837470214 Jun 201212 Feb 2013Medifocus, Inc.Drug delivery
US838274718 Oct 200726 Feb 2013Medtronic Cryocath LpMethod and apparatus for inflating and deflating balloon catheters
US84092661 Aug 20112 Apr 2013Boston Scientific Scimed, Inc.Cryotreatment device and method
US849163616 Oct 200623 Jul 2013Medtronic Cryopath LPMethod and apparatus for inflating and deflating balloon catheters
US8545491 *13 Dec 20051 Oct 2013Medtronic Cryocath LpMethod and apparatus for inflating and deflating balloon catheters
US857422520 Oct 20095 Nov 2013Boston Scientific Scimed, Inc.Efficient controlled cryogenic fluid delivery into a balloon catheter and other treatment devices
US8652190 *28 Feb 201118 Feb 2014Zoll Circulation, Inc.Heat exchange catheter apparatus and method for manipulating patient's body temperature
US884562718 Aug 200930 Sep 2014Boston Scientific Scimed, Inc.Regulating pressure to lower temperature in a cryotherapy balloon catheter
US884570728 Mar 201330 Sep 2014Boston Scientific Scimed, Inc.Cryotreatment device and method
US890022225 Jan 20132 Dec 2014Medtronic Cryocath LpMethod and apparatus for inflating and deflating balloon catheters
US894510723 Oct 20113 Feb 2015Medtronic Ardian Luxembourg S.A.R.L.Neuromodulation cryotherapeutic devices and associated systems and methods
US90173176 Dec 201228 Apr 2015Medtronic Ardian Luxembourg S.A.R.L.Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods
US905007417 Dec 20129 Jun 2015Boston Scientific Scimed, Inc.Cryosurgical fluid supply
US906075423 Oct 201123 Jun 2015Medtronic Ardian Luxembourg S.A.R.L.Neuromodulation cryotherapeutic devices and associated systems and methods
US906075523 Oct 201123 Jun 2015Medtronic Ardian Luxembourg S.A.R.L.Neuromodulation cryotherapeutic devices and associated systems and methods
US906671323 Oct 201130 Jun 2015Medtronic Ardian Luxembourg S.A.R.L.Neuromodulation cryotherapeutic devices and associated systems and methods
US909532121 Nov 20124 Aug 2015Medtronic Ardian Luxembourg S.A.R.L.Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US913834414 Feb 201422 Sep 2015Zoll Circulation, Inc.Apparatus and method of gastric cooling using balloon catheter
US924175227 Apr 201226 Jan 2016Medtronic Ardian Luxembourg S.A.R.L.Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
US955522326 Sep 200831 Jan 2017Medtronic Cryocath LpMethod and apparatus for inflating and deflating balloon catheters
US980167630 Sep 201431 Oct 2017Boston Scientific Scimed, Inc.Regulating pressure to lower temperature in a cryotherapy balloon catheter
US980830123 Oct 20147 Nov 2017Medtronic Cryocath LpMethod and apparatus for inflating and deflating balloon catheters
US20010007951 *16 Feb 200112 Jul 2001Innercool Therapies, IncCirculating fluid hypothermia method and apparatus
US20020151845 *20 Jun 200217 Oct 2002Randell WernethMultipurpose catheter assembly
US20020193854 *13 Aug 200219 Dec 2002Innercool Therapies, Inc.Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US20030023288 *9 Aug 200230 Jan 2003Michael MagersMethod and device for patient temperature control employing optimized rewarming
US20030060863 *9 Aug 200227 Mar 2003Dobak John D.Method and apparatus for patient temperature control employing administration of anti-shivering agents
US20030078641 *20 Dec 200224 Apr 2003Innercool Therapies, Inc.Selective organ hypothermia method and apparatus
US20030144714 *5 Mar 200331 Jul 2003Innercool Therapies, Inc.Selective organ hypothermia method and apparatus
US20030167034 *3 Jul 20024 Sep 2003Balding David P.Automatic fever abatement applications
US20030187489 *9 Apr 20032 Oct 2003Innercool Therapies, Inc.Fever regulation method and apparatus
US20030229384 *13 May 200311 Dec 2003Celsion CorporationMethod and apparatus for treatment of tissue adjacent a bodily conduit with a compression balloon
US20040049176 *10 Sep 200311 Mar 2004Scimed Life Systems, Inc.Cryoplasty device and method
US20040106969 *14 Nov 20033 Jun 2004Innercool Therapies, Inc.Inflatable catheter for selective organ heating and cooling and method of using the same
US20040116987 *5 Dec 200317 Jun 2004Innercool Therapies, Inc.Method for determining the effective thermal mass of a body or organ using a cooling catheter
US20040127851 *31 Dec 20021 Jul 2004Alsius CorporationSystem and method for controlling rate of heat exchange with patient
US20040143249 *27 Oct 200322 Jul 2004Scimed Life Systems, Inc., A Minnesota CorporationCryo balloon for atrial ablation
US20040147914 *7 Jan 200429 Jul 2004Kramer Hans W.Method and device for performing cooling- or cryo-therapies for, E.G., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US20040153133 *23 Jan 20045 Aug 2004Innercool Therapies, Inc.Selective organ cooling apparatus and method
US20040167505 *23 Feb 200426 Aug 2004Cryovascular Systems, Inc.Cryosurgical fluid supply
US20040199229 *26 Apr 20047 Oct 2004Innercool Therapies, Inc.Therapeutic heating and cooling via temperature management of a colon-inserted balloon
US20040215297 *28 Apr 200328 Oct 2004Alsius CorporationIntrarectal heat exchange catheter
US20040230265 *8 Mar 200418 Nov 2004Innercool Therapies, Inc.Selective organ cooling apparatus and method
US20040240660 *27 May 20032 Dec 2004Wong Kent Wah ShunSystem and method for retrieving telephone numbers
US20040243199 *30 Jun 20042 Dec 2004Celsion CorporationDevice and method for treatment of tissue adjacent a bodily conduit by thermocompression
US20040267250 *15 Jul 200430 Dec 2004Yon Steven A.Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US20050021113 *5 Aug 200427 Jan 2005Xanodyne Pharmaceuticals, Inc.System and method using the rectal mucosal membrane for inducing hypothermia and warming
US20050038421 *4 Jun 200317 Feb 2005Cryo Vascular Systems, Inc.Controllable pressure cryogenic balloon treatment system and method
US20050076924 *3 Sep 200414 Apr 2005Dobak John D.Medical procedure
US20050090806 *12 Nov 200428 Apr 2005Gmp Vision Solutions Inc.Shunt device and method for treating glaucoma
US20050096715 *3 Dec 20045 May 2005Innercool Therapies, Inc.Method and device for patient temperature control employing optimized rewarming
US20050171586 *21 Mar 20054 Aug 2005Dobak John D.IiiMethod and apparatus for patient temperature control employing administration of anti-shivering agents
US20050182395 *21 Mar 200518 Aug 2005Scimed Life Systems, Inc.Cryo balloon
US20050191585 *1 Mar 20041 Sep 2005Tsutomu SatoDeveloper agent for positive type photosensitive compound
US20050203498 *19 Feb 200315 Sep 2005Celsion CorporationMethod and apparatus treating tissue adjacent a bodily conduit with thermocompression and drugs
US20050215989 *23 Mar 200429 Sep 2005Cryocath Technologies Inc.Method and apparatus for inflating and deflating balloon catheters
US20050222652 *16 Jun 20036 Oct 2005Atsuo MoriCatheter for topical cooling and topical cooling device using the same
US20050222653 *16 May 20056 Oct 2005Alsius CorporationIndwelling heat exchange catheter and method of using same
US20050228368 *13 Jun 200513 Oct 2005Yon Steven AMethod and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US20050240250 *23 Jun 200527 Oct 2005Dobak John D IiiSelective organ hypothermia method and apparatus
US20060009824 *12 Sep 200512 Jan 2006Xanodyne Pharmaceuticals, Inc.System and method using the rectal mucosal membrane for inducing hypothermia and warming
US20060025839 *20 Sep 20052 Feb 2006Xanodyne Pharmaceuticals, Inc.System and method using the rectal mucosal membrane for inducing hypothermia and warming
US20060084962 *2 Dec 200520 Apr 2006Cryovascular Systems, Inc.Controllable pressure cryogenic balloon treatment system and method
US20060100495 *29 Mar 200511 May 2006Domenic SantoianniExtended treatment zone catheter
US20060122589 *13 Dec 20058 Jun 2006Cryocath Technologies Inc.Method and apparatus for inflating and deflating balloon catheters
US20060124141 *25 Jan 200615 Jun 2006Innercool Therapies, Inc.Patient temperature regulation method and apparatus
US20060129142 *15 Dec 200415 Jun 2006Cryovascular Systems, Inc.Efficient controlled cryogenic fluid delivery into a balloon catheter and other treatment devices
US20060136023 *26 Aug 200522 Jun 2006Dobak John D IiiMethod and apparatus for patient temperature control employing administration of anti-shivering agents
US20060178663 *17 Feb 200610 Aug 2006Scimed Life Systems, Inc., A Delaware CorporationCryoplasty device and method
US20060253095 *26 Jun 20069 Nov 2006Radiant Medical, Inc.Method for gastric cooling using balloon catheter
US20060276865 *16 Aug 20067 Dec 2006Dobak John D IiiFever regulation method and apparatus
US20070032783 *16 Oct 20068 Feb 2007Cryocath Technologies Inc.Method and apparatus for inflating and deflating balloon catheters
US20070250050 *12 Apr 200725 Oct 2007Scimed Life Systems, Inc. A Minnesota CorporationCryotreatment device and method
US20070293921 *31 Aug 200720 Dec 2007Alsius CorporationSystem and method for controlling rate of heat exchange with patient
US20080200970 *21 Dec 200721 Aug 2008Innercool Therapies, Inc.Patient temperature regulation method and apparatus
US20080221651 *13 May 200811 Sep 2008Innercool Therapies, Inc.Medical procedure
US20080275535 *3 Jul 20086 Nov 2008Atsuo MoriCatheter for Topical Cooling and Topical Cooling Device using the same
US20100042086 *20 Oct 200918 Feb 2010Boston Scientific Scimed, Inc.Efficient Controlled Cryogenic Fluid Delivery Into a Balloon Catheter and Other Treatment Devices
US20100049184 *18 Aug 200925 Feb 2010Boston Scientific Scimed, Inc.Regulating Pressure to Lower Temperature in a Cryotherapy Balloon Catheter
US20100106148 *5 Jan 201029 Apr 2010James JoyeCryosurgical Fluid Supply
US20100298913 *3 Aug 201025 Nov 2010Boston Scientific CorporationDevice and method for treatment of tissue adjacent a bodily conduit by thermocompression
US20110028886 *12 Oct 20103 Feb 2011Boston Scientific CorporationCatheter
US20110034976 *12 Oct 201010 Feb 2011John MonDrug delivery
US20110087204 *14 Dec 201014 Apr 2011Boston Scientific Scimed, Inc.Cryoplasty device and method
US20110166633 *28 Feb 20117 Jul 2011Zoll Circulation, Inc.Method of gastric cooling using balloon catheter
US20160193078 *21 Sep 20157 Jul 2016Zoll Circulation, Inc.Apparatus and Method Of Gastric Cooling Using Balloon Catheter
EP1894534A23 Jul 20015 Mar 2008Cryovascular Systems, Inc.Improved safety cryotherapy catheter
EP2147648B1 *14 Mar 200020 Jul 2016Cryovascular Systems, Inc.Cryosurgical fluid supply
WO1991005528A1 *19 Oct 19892 May 1991Granulab B.V.Device for cooling or heating a person
WO1995029643A2 *28 Apr 19959 Nov 1995Spembly Cryosurgery LimitedSurgical apparatus
WO1995029643A3 *28 Apr 199530 Nov 1995Brian Kevin Roderick ClarkeSurgical apparatus
WO2000038601A1 *23 Dec 19996 Jul 2000Alsius CorporationCooling system for indwelling heat exchange catheter
WO2002004042A2 *5 Jul 200117 Jan 2002Cryogen, Inc.Balloon cryogenic catheter
WO2002004042A3 *5 Jul 200116 May 2002Cryogen IncBalloon cryogenic catheter
WO2003105736A1 *16 Jun 200324 Dec 2003Atsuo MoriCatheter for topical cooling and topical cooling device using the same
WO2004017876A2 *8 Jul 20034 Mar 2004Serene Medical, Inc.System and method using the rectal mucosal membrane for inducing hypotermia and warming
WO2004017876A3 *8 Jul 200324 Feb 2005Xanodyne Pharmaceuticals IncSystem and method using the rectal mucosal membrane for inducing hypotermia and warming
Classifications
U.S. Classification607/105, 606/22
International ClassificationA61F7/12, A61B19/00, A61F7/00
Cooperative ClassificationA61F2007/0058, A61F7/123, A61B19/54
European ClassificationA61F7/12B