US2950717A - Ampules - Google Patents
Ampules Download PDFInfo
- Publication number
- US2950717A US2950717A US572440A US57244056A US2950717A US 2950717 A US2950717 A US 2950717A US 572440 A US572440 A US 572440A US 57244056 A US57244056 A US 57244056A US 2950717 A US2950717 A US 2950717A
- Authority
- US
- United States
- Prior art keywords
- ampule
- container
- holder
- wall
- threaded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003708 ampul Substances 0.000 title description 33
- 239000007788 liquid Substances 0.000 description 14
- 239000012815 thermoplastic material Substances 0.000 description 11
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 239000003814 drug Substances 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 210000003414 extremity Anatomy 0.000 description 6
- 239000012530 fluid Substances 0.000 description 4
- 239000011521 glass Substances 0.000 description 3
- 210000003813 thumb Anatomy 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/062—Carpules
Definitions
- the present invention relates to containers, and, more particularly, to hermetically closed containers.
- This invention relates, still more particularly, to ampules containing liquid medicaments, intended to be used, in combination with hypodermic injectors of the type comprising a holder, on one extremity of which a hollow needle is mounted, said needle comprising a part projecting inside the holder and, in the other extremity, a movable pusher, the ampule being adapted to be placed in said holder, one of its ends being arranged to be pierced by said hollow needle inner part.
- the known ampules of this type of hypodermic injectors are constituted by a glass tube closed at one of its ends by a thin wall and receiving in its other end a piston-plug usually made out of rubber, said thin wall being usually made either of rubber or of thin metal.
- the holder is usually provided with means to permit the operator to hold it with two fingers while the pusher is provided with means permitting to push the piston With the thumb.
- hypodermic injectors of the type specified are particularly useful for injections in the gums or in the bones, such injections requiring a strong push.
- the existing ampules to be used in combination with such injectors have different drawbacks.
- the glass tube can burst which, in turn, can provoke accidents.
- One of the objects of the present invention is to provide an ampule which has none of the drawbacks of the existing ampules.
- Another object of the invention is to provide an ampule of thermoplastic material for use in connection with a hypodermic injector, the body of said ampule having a generally tubular form, the wall of the tube being pleated so as to form a bellows, the end walls of of said tube being transverse to the axis of said tube and being hermetically sealed under sterile conditions after the liquid medicament has been introduced inside said body.
- ampule according to the invention ofiers furthermore practically no resistance when compressed, due to the bellows shape of its tubular body. Due to this shape, the axial deformation is rendered easier than in any other direction.
- Another object of the invention is to provide a container or ampule of thermoplastic material for use in connection with medical fluid injecting or collecting devices, but in which one of the transverse end walls is constituted by a thick annular disk on the outer face of which a threaded blind hole is formed.
- the inside end of the pusher rod is usually threaded, so that it can be threadably engaged in said blind threaded hole to permit the deformation of the bellows-like body of the ampule axially in both directions.
- Another object of the invention is to provide a container of the general type specified above, but in which no liquid is enclosed before sealing, said container being intended to be used in combination with a blood sucking or a blood collecting device, said device comprising a hollow needle to pierce one of the transverse wall ends and an actuating member to threadably engage the blind hole in the opposite transverse thick end wall to first collapse the container by axial deformation of its bellowslike body and then to bring it back to its normal shape, while sucking blood inside the container.
- Fig. 1 shows a sectional view of an ampule according to the invention.
- Fig. 2 is a similar view of a container forming, for instance, a liquid medicament ampule.
- Fig. 3 is a sectional view showing a hypodermic injector in combination with the ampule-container of Fig. 2.
- an ampule body constituted by a bellowslike tubular element 1 is closed hermetically at its extremities by two thin transverse walls 2 and 3, respectively. It must be well understood that to form an ampule one of said walls is sealed to the tubular body after a liquid medicament has been introduced in the tubular body under sterile conditions.
- the Fig. 1 shows, in fact, a complete ampule, to wit: the tubular body comprising the two transverse walls and a liquid medicament introduced, before scaling, in said body.
- thermoplastic material the ampule body is made of
- the specific nature of the thermoplastic material will be determined according to the liquid medicament in order to avoid every possible chemical reaction between the thermoplastic material and said liquid medicament.
- thermoplastic material is not necessarily very soft so that thermoplastic materials, other than polyethylene, may be used.
- ampule according to the invention is absolutely sterile, no leakage or penetration of air being possible.
- the ampule or container 1a is of the same general construction as the one shown in Fig. 1, said ampule differing however from the one shown in Fig. 1 by the fact that the thin wall 2 is replaced by a thick disk-shaped wall 4 in which a threaded blind hole 5 is formed.
- This thick wall can be used for collapsing or extending the ampule axially as desired.
- Fig. 3 shows a hypodermic injector comprising a holder body 9, one end of which is externally threaded for engagement with internal threads on a collar 15. At the other end of the holder 9 is mounted a hollow needle 10, one of the extremities 11 of said needle protruding inside the holder so as to pierce the thin walled extremity 3 of an ampule 1a mounted in said holder.
- the collar 15 at said one end of the holder 9 has an internally threaded, centrally disposed bore therethrough to receive and externally threaded sleeve 17 within which is mounted a push-rod 6, the extremity 8 of which is threaded so as to be engageable in the'internally threaded blind hole 5 in the thick end wall 4 of the ampule 1a.
- An abutment 7 is provided on the push rod 6 to limit the penetration of the threaded end 8 in the hole 5 and to increase the area of contact between the push-rod 6 and the thick wall 4 to permit said wall 4 to better resist mechanical stresses.
- the holder 9 is held by two fingers engageable in the eyelets 12 and 13, while an eyelet 14 is provided on the push-rod 6 to receive the thumb.
- Fig. 3 offers the further advantage of permitting the use of an ampule 1a as an empty container for blood collection or for any other application in which a liquid is to be collected in a sterile container.
- 1a is first flattened as for injection by pushing the rod 6 home to blow out any air it contains, whereupon the needle is introduced e.g. into a vein of the patient. To suck the blood into the empty container, it then suffices to draw slowly on the rod 6.
- the use of a collapsible container according to the invention has the essential advantage of avoiding any passage or introduction of external air in the blood or other collected liquid as with the usual blood sucking devices.
- an ampule of which the liquid is merely an antiseptic having no chemical action on blood may be used for blood collection.
- the said liquid will be merely ejected from the container by fully flattening the same under compression by means of the pushrod before effecting the blood collection as exposed above.
- a fluid container of thermoplastic material for use in connection with medical fluid injecting or collecting devices, said container comprising a tubular, bellows-like, body having an integral thin transverse end wall and an integral thick transverse wall, and a blind threaded hole formed in the outer face of said thick transverse wall.
Description
3Q, 1969 BQUET 2,950,717 AMEULES Filed March 19, 1956 INVENTOR B. M. E. BOUET ATTORNEYS it nite tates Patent (3 Patented Aug. 30, 1960 AMPULES Bernard Maurice Edouard Bouet, Paris, France, assignor to R. K. Price Associates, Inc., New York, N.Y.
Filed Mar. 19, 1956, Ser. No. 572,440
Claims priority, application France Mar. 21, 1955 2 Claims. (Cl. 128-218) The present invention relates to containers, and, more particularly, to hermetically closed containers.
This invention relates, still more particularly, to ampules containing liquid medicaments, intended to be used, in combination with hypodermic injectors of the type comprising a holder, on one extremity of which a hollow needle is mounted, said needle comprising a part projecting inside the holder and, in the other extremity, a movable pusher, the ampule being adapted to be placed in said holder, one of its ends being arranged to be pierced by said hollow needle inner part.
The known ampules of this type of hypodermic injectors are constituted by a glass tube closed at one of its ends by a thin wall and receiving in its other end a piston-plug usually made out of rubber, said thin wall being usually made either of rubber or of thin metal.
To make an injection with the known combination, one introduces the ampule in said holder with the thin wall brought against the hollow needle inner part, so as to be pierced by the same, while the piston-plug, closing the other end of the ampule, is brought against said pusher end.
The holder is usually provided with means to permit the operator to hold it with two fingers while the pusher is provided with means permitting to push the piston With the thumb.
The hypodermic injectors of the type specified are particularly useful for injections in the gums or in the bones, such injections requiring a strong push. The existing ampules to be used in combination with such injectors have different drawbacks.
It is very diflicult to keep the liquid sterile due to the difficulty of making the piston-tube assembly completely air-tight. The necessity of a good seal increases naturally the resistance ofi'ered by the piston, while it is slidably displaced along the tube.
It is also to be noted that certain liquids have a chemical action on the rubber.
Furthermore, due to high pressures developed inside the ampule during the injection, particularly when the same is made in a bone, the glass tube can burst which, in turn, can provoke accidents.
One of the objects of the present invention is to provide an ampule which has none of the drawbacks of the existing ampules.
Another object of the invention is to provide an ampule of thermoplastic material for use in connection with a hypodermic injector, the body of said ampule having a generally tubular form, the wall of the tube being pleated so as to form a bellows, the end walls of of said tube being transverse to the axis of said tube and being hermetically sealed under sterile conditions after the liquid medicament has been introduced inside said body.
It will be readily understood that such an ampule will be perfectly sterile due to the hermetical seal link. Furthermore, the resistance of certain thermoplastic materials avoids the possibility of bursting under pressure and, anyhow, the danger of accidents which could be produced by the particles of broken glass tubes.
The ampule according to the invention ofiers furthermore practically no resistance when compressed, due to the bellows shape of its tubular body. Due to this shape, the axial deformation is rendered easier than in any other direction.
In certain cases, it is desirable or necessary to be able to deform the ampule in the direction opposite to the one which determines the injection.
Another object of the invention is to provide a container or ampule of thermoplastic material for use in connection with medical fluid injecting or collecting devices, but in which one of the transverse end walls is constituted by a thick annular disk on the outer face of which a threaded blind hole is formed.
In the existing hypodermic injectors of the type specified, the inside end of the pusher rod is usually threaded, so that it can be threadably engaged in said blind threaded hole to permit the deformation of the bellows-like body of the ampule axially in both directions.
Another object of the invention is to provide a container of the general type specified above, but in which no liquid is enclosed before sealing, said container being intended to be used in combination with a blood sucking or a blood collecting device, said device comprising a hollow needle to pierce one of the transverse wall ends and an actuating member to threadably engage the blind hole in the opposite transverse thick end wall to first collapse the container by axial deformation of its bellowslike body and then to bring it back to its normal shape, while sucking blood inside the container.
Preferred embodiments of the invention will be hereinafter described with reference to the accompanying drawings, given merely by way of example and in which:
Fig. 1 shows a sectional view of an ampule according to the invention.
Fig. 2 is a similar view of a container forming, for instance, a liquid medicament ampule.
Fig. 3 is a sectional view showing a hypodermic injector in combination with the ampule-container of Fig. 2.
In Fig. 1, an ampule body constituted by a bellowslike tubular element 1 is closed hermetically at its extremities by two thin transverse walls 2 and 3, respectively. It must be well understood that to form an ampule one of said walls is sealed to the tubular body after a liquid medicament has been introduced in the tubular body under sterile conditions. The Fig. 1 shows, in fact, a complete ampule, to wit: the tubular body comprising the two transverse walls and a liquid medicament introduced, before scaling, in said body.
It must be also well understood that the thermoplastic material, the ampule body is made of, can be any conventional thermoplastic material such as polyethylene, polyvinyl chloride, etc. The specific nature of the thermoplastic material will be determined according to the liquid medicament in order to avoid every possible chemical reaction between the thermoplastic material and said liquid medicament.
Due to the bellows-like structure, the thermoplastic material is not necessarily very soft so that thermoplastic materials, other than polyethylene, may be used.
It will be clear that an ampule according to the invention is absolutely sterile, no leakage or penetration of air being possible.
In Fig. 2, the ampule or container 1a is of the same general construction as the one shown in Fig. 1, said ampule differing however from the one shown in Fig. 1 by the fact that the thin wall 2 is replaced by a thick disk-shaped wall 4 in which a threaded blind hole 5 is formed. This thick wall can be used for collapsing or extending the ampule axially as desired.
Fig. 3 shows a hypodermic injector comprising a holder body 9, one end of which is externally threaded for engagement with internal threads on a collar 15. At the other end of the holder 9 is mounted a hollow needle 10, one of the extremities 11 of said needle protruding inside the holder so as to pierce the thin walled extremity 3 of an ampule 1a mounted in said holder. The collar 15 at said one end of the holder 9 has an internally threaded, centrally disposed bore therethrough to receive and externally threaded sleeve 17 within which is mounted a push-rod 6, the extremity 8 of which is threaded so as to be engageable in the'internally threaded blind hole 5 in the thick end wall 4 of the ampule 1a. An abutment 7 is provided on the push rod 6 to limit the penetration of the threaded end 8 in the hole 5 and to increase the area of contact between the push-rod 6 and the thick wall 4 to permit said wall 4 to better resist mechanical stresses.
The holder 9 is held by two fingers engageable in the eyelets 12 and 13, while an eyelet 14 is provided on the push-rod 6 to receive the thumb.
To make a hypodermic injection, one has simply to push with the thumb on the push-rod 6, the abutment 7 of which compresses the ampule 1a so that the same collapses axially.
The combination of Fig. 3 offers the further advantage of permitting the use of an ampule 1a as an empty container for blood collection or for any other application in which a liquid is to be collected in a sterile container. For this purpose, after having placed an empty container of the type of Fig. 2 in the injector of Fig. 3, and after having screwed the push-rod 6 in the threaded hole 5, 1a is first flattened as for injection by pushing the rod 6 home to blow out any air it contains, whereupon the needle is introduced e.g. into a vein of the patient. To suck the blood into the empty container, it then suffices to draw slowly on the rod 6. It is to be noted that,
4 in this application, the use of a collapsible container according to the invention, has the essential advantage of avoiding any passage or introduction of external air in the blood or other collected liquid as with the usual blood sucking devices.
Alternatively, an ampule of which the liquid is merely an antiseptic having no chemical action on blood may be used for blood collection. In this case, the said liquid will be merely ejected from the container by fully flattening the same under compression by means of the pushrod before effecting the blood collection as exposed above.
What is claimed is:
1. A fluid container of thermoplastic material for use in connection with medical fluid injecting or collecting devices, said container comprising a tubular, bellows-like, body having an integral thin transverse end wall and an integral thick transverse wall, and a blind threaded hole formed in the outer face of said thick transverse wall.
2. The combination with a fluid-injecting or collecting device for medical use, said device comprising a holder for -a tubular element, a hollow needle protruding inside one end of said holder and an axially movable actuating member in the other end of said holder provided with a threaded end inside said holder; of a hermetically sealed fluid, sterile container of thermoplastic material comprising a tubular, bellows-like, body engaged in said References Cited in the file of this patent UNITED STATES PATENTS 1,604,224 Friedman Oct. 26, 1926 1,880,354 Mueller Oct. 4, 1932 2,667,165 Smith Jan. 26, 1954 2,696,212 Dunmire Dec. 7, 1954 2,717,598 Krasno Sept. 13, 5
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR2950717X | 1955-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
US2950717A true US2950717A (en) | 1960-08-30 |
Family
ID=9690267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US572440A Expired - Lifetime US2950717A (en) | 1955-03-21 | 1956-03-19 | Ampules |
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US (1) | US2950717A (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3099264A (en) * | 1962-07-11 | 1963-07-30 | Raymond E Hubbard | Disposable syringe and compression device therefor |
US3161194A (en) * | 1963-02-04 | 1964-12-15 | Samuel L Chapman | Hypodermic syringe |
US3166070A (en) * | 1961-12-05 | 1965-01-19 | Lapis Engineering Company Ltd | Syringe for hypodermic injection |
US3190619A (en) * | 1963-05-27 | 1965-06-22 | Union Carbide Corp | Fluid mixing container assembly |
US3496937A (en) * | 1967-05-18 | 1970-02-24 | John E Balson | Hypodermic syringe |
JPS5064490U (en) * | 1973-10-15 | 1975-06-11 | ||
US4392491A (en) * | 1980-08-05 | 1983-07-12 | Colpo Company Limited | Injector |
WO1984001900A1 (en) * | 1982-11-16 | 1984-05-24 | Bioresearch Inc | Autotransfusion device with twisted collection bag |
US5308322A (en) * | 1993-04-19 | 1994-05-03 | Tennican Patrick O | Central venous catheter access system |
US5344397A (en) * | 1992-06-26 | 1994-09-06 | Advanced Surgical, Inc. | Cholangiogram catheter |
US5592948A (en) * | 1994-01-28 | 1997-01-14 | Gatten; Ronald A. | Self contained vial for drawing, storing, sealing and identifying a fluid sample |
DE19545838A1 (en) * | 1995-12-08 | 1997-06-12 | Karlheinz Dr Med Rothenberger | Hypodermic |
US5683369A (en) * | 1994-04-12 | 1997-11-04 | Tsukada Medical Research Co., Ltd. | Bellows type container charged with liquid medicine |
US5836922A (en) * | 1995-06-21 | 1998-11-17 | Bernd Hansen | Container for delivery of flowable material |
US6077252A (en) * | 1997-09-17 | 2000-06-20 | Siegel; Robert | Single or multiple dose syringe |
US6083204A (en) * | 1998-09-29 | 2000-07-04 | Malerba; Richard | Method and apparatus for gravity-fed intravenous infusion |
EP1225937A1 (en) * | 1999-09-09 | 2002-07-31 | Tri-Med International, LLC | Multiple-dose syringe |
US20030167041A1 (en) * | 1999-09-09 | 2003-09-04 | Rosoff Jack P. | Multiple-dose syringe |
US20050038315A1 (en) * | 2003-08-12 | 2005-02-17 | Slo-Flo Ltd. | Motorized syringe particularly useful for intra-uterine insemination |
US7077826B1 (en) * | 2002-01-24 | 2006-07-18 | Robin Scott Gray | Syringe and method of using |
US9180252B2 (en) | 2012-04-20 | 2015-11-10 | Bayer Medical Care Inc. | Bellows syringe fluid delivery system |
US9498570B2 (en) | 2010-10-25 | 2016-11-22 | Bayer Healthcare Llc | Bladder syringe fluid delivery system |
US20160367758A1 (en) * | 2015-06-16 | 2016-12-22 | ZebraSci, Inc | Self-Lubricating Medical Syringes |
US20170197031A1 (en) * | 2014-06-04 | 2017-07-13 | Merck Sharp & Dohme Corp. | Prefilled disposable injection device |
US10046106B2 (en) | 2010-10-25 | 2018-08-14 | Bayer Healthcare Llc | Bladder syringe fluid delivery system |
IT201700090397A1 (en) * | 2017-08-04 | 2019-02-04 | Medesy Srl | SYRINGE FOR DENTISTRY |
US10583256B2 (en) | 2014-04-25 | 2020-03-10 | Bayer Healthcare Llc | Syringe with rolling diaphragm |
US10933190B2 (en) | 2015-04-24 | 2021-03-02 | Bayer Healthcare Llc | Syringe with rolling diaphragm |
US11123499B2 (en) * | 2016-01-19 | 2021-09-21 | Merck Sharp & Dohme Corp. | Prefilled disposable injection device |
US11207462B2 (en) | 2016-10-17 | 2021-12-28 | Bayer Healthcare Llc | Fluid injector with syringe engagement mechanism |
US11389585B2 (en) | 2016-09-16 | 2022-07-19 | Bayer Healthcare Llc | Pressure jacket having syringe retaining element |
US11547793B2 (en) | 2016-10-17 | 2023-01-10 | Bayer Healthcare Llc | Fluid injector with syringe engagement mechanism |
US11826541B2 (en) | 2017-09-13 | 2023-11-28 | Bayer Healthcare Llc | Sliding syringe cap for separate filling and delivery |
US11839751B2 (en) | 2020-06-18 | 2023-12-12 | Bayer Healthcare Llc | In-line air bubble suspension apparatus for angiography injector fluid paths |
US11918775B2 (en) | 2019-09-10 | 2024-03-05 | Bayer Healthcare Llc | Pressure jackets and syringe retention features for angiography fluid injectors |
US11938093B2 (en) | 2020-02-21 | 2024-03-26 | Bayer Healthcare Llc | Fluid path connectors for medical fluid delivery |
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US1604224A (en) * | 1925-07-21 | 1926-10-26 | Friedman Benjamin | Syringe |
US1880354A (en) * | 1931-07-30 | 1932-10-04 | Herman C Mueller | Fluid gun |
US2667165A (en) * | 1952-03-19 | 1954-01-26 | Arthur E Smith | Disposable syringe |
US2696212A (en) * | 1951-09-28 | 1954-12-07 | Russell P Dunmire | Hypodermic syringe |
US2717598A (en) * | 1952-11-21 | 1955-09-13 | Louis R Krasno | Hypodermic syringe |
-
1956
- 1956-03-19 US US572440A patent/US2950717A/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1604224A (en) * | 1925-07-21 | 1926-10-26 | Friedman Benjamin | Syringe |
US1880354A (en) * | 1931-07-30 | 1932-10-04 | Herman C Mueller | Fluid gun |
US2696212A (en) * | 1951-09-28 | 1954-12-07 | Russell P Dunmire | Hypodermic syringe |
US2667165A (en) * | 1952-03-19 | 1954-01-26 | Arthur E Smith | Disposable syringe |
US2717598A (en) * | 1952-11-21 | 1955-09-13 | Louis R Krasno | Hypodermic syringe |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3166070A (en) * | 1961-12-05 | 1965-01-19 | Lapis Engineering Company Ltd | Syringe for hypodermic injection |
US3099264A (en) * | 1962-07-11 | 1963-07-30 | Raymond E Hubbard | Disposable syringe and compression device therefor |
US3161194A (en) * | 1963-02-04 | 1964-12-15 | Samuel L Chapman | Hypodermic syringe |
US3190619A (en) * | 1963-05-27 | 1965-06-22 | Union Carbide Corp | Fluid mixing container assembly |
US3496937A (en) * | 1967-05-18 | 1970-02-24 | John E Balson | Hypodermic syringe |
JPS5064490U (en) * | 1973-10-15 | 1975-06-11 | ||
US4392491A (en) * | 1980-08-05 | 1983-07-12 | Colpo Company Limited | Injector |
WO1984001900A1 (en) * | 1982-11-16 | 1984-05-24 | Bioresearch Inc | Autotransfusion device with twisted collection bag |
US4500308A (en) * | 1982-11-16 | 1985-02-19 | Bioresearch Inc. | Autotransfusion device with twisted collection bag |
US5344397A (en) * | 1992-06-26 | 1994-09-06 | Advanced Surgical, Inc. | Cholangiogram catheter |
US5308322A (en) * | 1993-04-19 | 1994-05-03 | Tennican Patrick O | Central venous catheter access system |
US5592948A (en) * | 1994-01-28 | 1997-01-14 | Gatten; Ronald A. | Self contained vial for drawing, storing, sealing and identifying a fluid sample |
US5683369A (en) * | 1994-04-12 | 1997-11-04 | Tsukada Medical Research Co., Ltd. | Bellows type container charged with liquid medicine |
US5836922A (en) * | 1995-06-21 | 1998-11-17 | Bernd Hansen | Container for delivery of flowable material |
DE19545838A1 (en) * | 1995-12-08 | 1997-06-12 | Karlheinz Dr Med Rothenberger | Hypodermic |
US6077252A (en) * | 1997-09-17 | 2000-06-20 | Siegel; Robert | Single or multiple dose syringe |
US6083204A (en) * | 1998-09-29 | 2000-07-04 | Malerba; Richard | Method and apparatus for gravity-fed intravenous infusion |
US7011650B2 (en) | 1999-09-09 | 2006-03-14 | Paradigm Medical, Llc | Multiple-dose syringe with collapsible container |
EP1225937A1 (en) * | 1999-09-09 | 2002-07-31 | Tri-Med International, LLC | Multiple-dose syringe |
US20030167041A1 (en) * | 1999-09-09 | 2003-09-04 | Rosoff Jack P. | Multiple-dose syringe |
EP1225937B1 (en) * | 1999-09-09 | 2005-07-13 | Paradigm Medical, LLC | Multiple-dose syringe |
US7077826B1 (en) * | 2002-01-24 | 2006-07-18 | Robin Scott Gray | Syringe and method of using |
US20050038315A1 (en) * | 2003-08-12 | 2005-02-17 | Slo-Flo Ltd. | Motorized syringe particularly useful for intra-uterine insemination |
US10835680B2 (en) | 2010-10-25 | 2020-11-17 | Bayer Healthcare Llc | Bladder syringe fluid delivery system |
US9498570B2 (en) | 2010-10-25 | 2016-11-22 | Bayer Healthcare Llc | Bladder syringe fluid delivery system |
US10046106B2 (en) | 2010-10-25 | 2018-08-14 | Bayer Healthcare Llc | Bladder syringe fluid delivery system |
US9180252B2 (en) | 2012-04-20 | 2015-11-10 | Bayer Medical Care Inc. | Bellows syringe fluid delivery system |
US10105491B2 (en) | 2012-04-20 | 2018-10-23 | Bayer Healthcare Llc | Collapsible syringe for fluid delivery system |
US11717614B2 (en) | 2014-04-25 | 2023-08-08 | Bayer Healthcare Llc | Syringe with rolling diaphragm |
US10583256B2 (en) | 2014-04-25 | 2020-03-10 | Bayer Healthcare Llc | Syringe with rolling diaphragm |
US20170197031A1 (en) * | 2014-06-04 | 2017-07-13 | Merck Sharp & Dohme Corp. | Prefilled disposable injection device |
US10543317B2 (en) * | 2014-06-04 | 2020-01-28 | Merck Sharp & Dohme Corp. | Prefilled disposable injection device |
US10933190B2 (en) | 2015-04-24 | 2021-03-02 | Bayer Healthcare Llc | Syringe with rolling diaphragm |
US9999731B2 (en) * | 2015-06-16 | 2018-06-19 | ZebraSci, Inc | Self-lubricating medical syringes |
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