US2579280A - Inhaler - Google Patents

Inhaler Download PDF

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Publication number
US2579280A
US2579280A US101398A US10139849A US2579280A US 2579280 A US2579280 A US 2579280A US 101398 A US101398 A US 101398A US 10139849 A US10139849 A US 10139849A US 2579280 A US2579280 A US 2579280A
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United States
Prior art keywords
inhaler
passage
butt
cap
air
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US101398A
Inventor
George P Trumbour
Jr Harlan I Prater
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MACGREGOR INSTR Co
MACGREGOR INSTRUMENT Co
Original Assignee
MACGREGOR INSTR Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MACGREGOR INSTR Co filed Critical MACGREGOR INSTR Co
Priority to US101398A priority Critical patent/US2579280A/en
Application granted granted Critical
Publication of US2579280A publication Critical patent/US2579280A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0001Details of inhalators; Constructional features thereof
    • A61M15/0013Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0016Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Definitions

  • Our present invention relates to inhalers and particularly to inhalers for use with medicaments such as powdered penicillin.
  • an inhaler comprising a body having a passage extending from'its butt to its tip and being of increased cross sectional area adjacent the butt.
  • a cap serving as a container for the medicament, is detachably connected to the butt with its closed end spaced from the enlarged extremity of that passage and our inhaler has air intake passages in communication with the interior of the cap and disposed towards its closed I end.
  • the inhaler body with a valve in control of thepassage.
  • the valve includes a valve element and first and second spaced seats therefor.
  • the element engages the first seat under the'infiuence of exhaled air thereby preventing moisture-from that source causing the powdered medicament to' agglomerate.
  • the valve element is lifted from the first seat but the second seat is grooved so that should it be engaged by the valve element, the passage will remain Open.
  • Fig. 1 is a longitudinal section, on an enlarged scale, of an inhaler in accordance with our invention.
  • Figs. 2 and 3 are sections along the lines 22 and 3--3, respectively, of Fig. 1.
  • an inhaler consisting of a body 5, preferably of tubular form, having one end rounded to provide a tip dimensioned so that it is adapted for both nasal and oral uses.
  • a cap-like vial 6 containing the medicament 1 is detachably connected to the butt end of the body 5.
  • the body 5 has a passage 8 extending from end to end thereof and the inhaler has intake passageways 9 in communication with the interior of the cap 6.
  • the mouth of the cap 6 is slightly tapered to fit securely on the correspondingly tapered butt 12 of the body 5 and be seated against; the body shoulder is.
  • Extending the full length of the butt l2 and intersecting the shoulder. l3 are a plurality of spaced grooves which, in the assembled inhaler, establish the intake passageways 9.
  • We prefer this construction as it ensures that the streams of air drawn into the cap 6 are in contact with its inner surfaces.
  • the body 5 as including an extension member l4 having a tapered neck l5 fitting into the correspondingly tapered end of a passage chamber IS.
  • the chamber I16 is of substantially greater cross sectional area than the adjacent portions of the passage 8 and receives the valve element l1, preferably a ball.
  • the shoulder established by the received end of the neck l5 establishes a first seat I8 for the valve element and spaced therefrom is a second seat I9.
  • valve element I1 is positioned: for use.
  • the extension member l4 has an in The extension member-M ,-i ...dimen-...
  • An inhaler comprising a body having a tip
  • An inhaler comprising a. body having a tip

Description

1951 G. P. TRUMBOUR ETA; 2,579,280.
INHALER Filed June 25, 1949 INVENTORS GEORGE Z? TRUMBOUR HARLn/v 1. PR arm JR.
ATTORNEY Patented Dec. 18, 1951 INHALER George P. Trumbour, Needham, and Harlan I. Prater, Jr., Wellesley Hills, Mass., assignors to MacGregor Instrument Company, Needham,
Mass, a corporation Application June 25, 1949, Serial No. 101,398
' 7 Claims. (01.128-206) Our present invention relates to inhalers and particularly to inhalers for use with medicaments such as powdered penicillin.
Where such medicaments are to be taken by inspiration, it is essential that the patient receive the full dosage prescribed and it is to inhalers that enable that result to be effectively attained and that, at the same time, are adapted to economical production that our invention is directed. 1
In accordance with our invention, we provide an inhaler comprising a body having a passage extending from'its butt to its tip and being of increased cross sectional area adjacent the butt. A cap, serving as a container for the medicament, is detachably connected to the butt with its closed end spaced from the enlarged extremity of that passage and our inhaler has air intake passages in communication with the interior of the cap and disposed towards its closed I end.
In practice, we provide that the fiow of intake air is accelerated in the zone of the butt end of the body passage to ensure that air drawn into the cap is in the form of streams sweeping its inner surfaces to the closed end thereof with the result that all-the medicamentmay be picked up-gby the inspirated air stream. .7
We also provide the inhaler body with a valve in control of thepassage. The valve includes a valve element and first and second spaced seats therefor. The element engages the first seat under the'infiuence of exhaled air thereby preventing moisture-from that source causing the powdered medicament to' agglomerate. When the patient inhales through our inhaler, the valve element is lifted from the first seat but the second seat is grooved so that should it be engaged by the valve element, the passage will remain Open.
In the accompanying drawings, we have shown an illustrative embodiment of our invention from which these and other of its novel features and advantages will be readily apparent.
In the drawings:
Fig. 1 is a longitudinal section, on an enlarged scale, of an inhaler in accordance with our invention, and
Figs. 2 and 3 are sections along the lines 22 and 3--3, respectively, of Fig. 1.
In accordance with our invention, we provide an inhaler consisting of a body 5, preferably of tubular form, having one end rounded to provide a tip dimensioned so that it is adapted for both nasal and oral uses. A cap-like vial 6 containing the medicament 1 is detachably connected to the butt end of the body 5. The body 5 has a passage 8 extending from end to end thereof and the inhaler has intake passageways 9 in communication with the interior of the cap 6.
In order that all the medicament 1 may be inspirated through the passage 8, we dispose the intake passageways 9 so that they are remote from but directed towards the closed end of the cap 6 and. form the passage 8 so that its adja-' cent end I0 is of greater cross sectional area than the tip end thereof. By this construction, entrant air streams over the inner surfaces of the cap 6 and sweeps the medicament therefrom and from its closed end into the stream through the passage 8, the mouth [0 of which is suitably: screened as at I l While any type of connection between the: inhaler body 5 and its cap 6 may be employed, we prefer to utilize a friction fit between them. For that reason, the mouth of the cap 6 is slightly tapered to fit securely on the correspondingly tapered butt 12 of the body 5 and be seated against; the body shoulder is. Extending the full length of the butt l2 and intersecting the shoulder. l3 are a plurality of spaced grooves which, in the assembled inhaler, establish the intake passageways 9. We prefer this construction as it ensures that the streams of air drawn into the cap 6 are in contact with its inner surfaces. in
While a thus constructed inhaler is very satisfactory in use and is adapted to economical production, it is desirable to have the passage 8 valve controlled to prevent air, exhaled by the patient, from entering the interior of the cap 6 for the moisture carried by that air would be picked up by the medicament with such resulting agglomeration as to destroy its utility.
In order to provide such a valve, we have shown the body 5 as including an extension member l4 having a tapered neck l5 fitting into the correspondingly tapered end of a passage chamber IS. The chamber I16 is of substantially greater cross sectional area than the adjacent portions of the passage 8 and receives the valve element l1, preferably a ball. The shoulder established by the received end of the neck l5 establishes a first seat I8 for the valve element and spaced therefrom is a second seat I9. In practice, we form the valve chamber It with a plurality of spaced grooves 20 which intersect the seat [9 and provide lands 2| which serve to closely confine the valve element as it travels between its seats.
By this construction, the valve element I1 is positioned: for use.
Apart from its use in the establishment oi. the valve, the extension member l4 has an in The extension member-M ,-i ...dimen-...
stituting a medicament container attached to said body with its closed end spaced from the butt end of said passage and its walls spaced from the extremity of said butt thereby to establish an air chamber having its mouth opening towards said closed end, said inhaler having inlets in commllnication, with said air chamber 'and the mouth of said chamber being of restricted size so that the streams of intake air are accelerated in the zone of the butt end of said passage.
4,. An inhaler comprising a body having a tip,
a butt, and a passage effectingcommunication thenebetween -.wi tl r .its. butt end of greater cross ber 14 is tapered as at 23 and the inn er; s riagea,
of the walls of the vial taper inwardly towards the closed end thereof so that the mouthi" of the chamber 22 is of substantially reduced cross sectional area,as...compared..with itsother end. As a result, the. stream of entrant air isaccelerated in the zone of thescreened. end or mouth of V the passage. 8. where theinspirated. air stream has not attained its fullveloci-ty thereby ensuring. that s the stream of entrant air is efiectivelto sweep the entireinterior ofthe. vialB, including its closed It will: be apparentfromtheforegoing that inhalersinaccordance without invention are well zadapted; foruse. in the. accurate administration of" powdered medicaments and to. efficient and economical production.
-What. we .thereforeclaim and desire to secure withv said air chamber. and the mouth of. said chamber being. .of .restrictedsize. so that. the streams of intake air are accelerated .in the zone ofithe butt end ofsaid passage.
2.1.;Theinhaler ofaclaim. 1 in whichone of the. adjacent surfaces of the. cap and butt extremity -..i ;l ned: towards .the. other. so that. the. air
ham ertaperstowards. its mouth.
3.; An inhaler comprising a. body having a tip,
a- ;-butt, and a passage effecting communication .55; sectional area, than its t pend, and a cap con-..
therehetween .withits. butt end. of: greatercross sectional areathan; the tip end thereof, an intermediateportion establishing a seat, and grooves traversingsaid seat and at least a part of said bl tt end anextension member including a neck seated in said butt end in spaced relation to said seat and having a passageway extending from end to end thereof, and a valve element confined in said butt portion by theseat established by the intermediate. passageportion. and by theseat. established by theextremity of said neck, a cap constituting a medicamentcontaineitsaid. cap and saidbo dy including Icomplem'ental.jointes: tablishingportions, connecting saidcapto said; body with its closed-end spaced; from said. exten-v sion. nd said extension. member .being dimenr. sione o fit freely. Within. said .cap to :pmvidean.
, air space, and one of said portions haVingwPaS-a.
l-Lmuunoua HARLAN:.I- HEATER; .J-R. mminen 1 cusp- The following references,=.-are ofrecord: in'. the; file .of this-patent: r
' UMTEDSTAIITESTPA'ITENIQ umbel l i Name a e .c 2 2 2 z :0 -81 g 2 35 ,Z e July. 2 5, 19%.E
US101398A 1949-06-25 1949-06-25 Inhaler Expired - Lifetime US2579280A (en)

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Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3027897A (en) * 1959-07-23 1962-04-03 Carofiglio Louis Edward Nasal inhaler
US4274403A (en) * 1979-08-29 1981-06-23 Struve Roger L Inhaler
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
AU640764B2 (en) * 1990-04-12 1993-09-02 Chiesi Farmaceutici S.P.A. Device for the administration of powdered medicinal substances
US5355873A (en) * 1990-07-27 1994-10-18 Bon F Del An inhalation device and method having a variably restrictable air inlet that allows the inhalation force required to overcome a locking element to be changed
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5568807A (en) * 1994-06-10 1996-10-29 Mecikalski; Mark B. Air-flow control for an inhaler
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5724959A (en) * 1990-10-02 1998-03-10 Aea Technology Plc Powder inhaler with specific orifice and baffle arrangement
WO1999013930A1 (en) * 1997-09-18 1999-03-25 Glaxo Group Limited Intranasal administration device
US6055979A (en) * 1996-04-02 2000-05-02 Ing. Erich Pfeiffer Gmbh Dosing and discharging device for flowable media including powder/air dispersions
US6095136A (en) * 1997-03-14 2000-08-01 Astra Aktiebolag Inhalation device
US6102036A (en) * 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
US6234169B1 (en) * 1998-08-14 2001-05-22 Arthur Slutsky Inhaler
WO2004012802A1 (en) * 2002-08-05 2004-02-12 Budai Laszlo Inhaler apparatus for mitigating respiratory complaints
WO2009134157A2 (en) * 2008-03-26 2009-11-05 S.C. Medical Pharma Salt S.R.L. Inhaler
USD642330S1 (en) 2009-10-26 2011-07-26 Jeffrey Turner Delivery device
US9050431B2 (en) 2010-10-18 2015-06-09 Jeffrey turner Device for dispensing a medium
JP2015521526A (en) * 2012-06-25 2015-07-30 レスピラ セラピューティクス インコーポレイテッドRespira Therapeutics,Inc. Powder dispersion device and method
US20150314086A1 (en) * 2012-02-21 2015-11-05 Respira Therapeutics, Inc. Powder inhaler, system and methods
US9545489B2 (en) 2010-10-18 2017-01-17 Jeffrey Turner Device for dispensing a medium
CN107427650A (en) * 2015-01-14 2017-12-01 瑞必治公司 Powder process for dispersing and device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US567558A (en) * 1896-09-08 Inhaler
US2024249A (en) * 1930-08-18 1935-12-17 Robinson Joseph Vaporizer
US2310681A (en) * 1942-03-04 1943-02-09 Victor Metal Products Corp Inhaler
US2354255A (en) * 1942-09-22 1944-07-25 Donald E Gillum Check valve

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US567558A (en) * 1896-09-08 Inhaler
US2024249A (en) * 1930-08-18 1935-12-17 Robinson Joseph Vaporizer
US2310681A (en) * 1942-03-04 1943-02-09 Victor Metal Products Corp Inhaler
US2354255A (en) * 1942-09-22 1944-07-25 Donald E Gillum Check valve

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3027897A (en) * 1959-07-23 1962-04-03 Carofiglio Louis Edward Nasal inhaler
US4274403A (en) * 1979-08-29 1981-06-23 Struve Roger L Inhaler
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
AU640764B2 (en) * 1990-04-12 1993-09-02 Chiesi Farmaceutici S.P.A. Device for the administration of powdered medicinal substances
US5355873A (en) * 1990-07-27 1994-10-18 Bon F Del An inhalation device and method having a variably restrictable air inlet that allows the inhalation force required to overcome a locking element to be changed
US5724959A (en) * 1990-10-02 1998-03-10 Aea Technology Plc Powder inhaler with specific orifice and baffle arrangement
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US6102036A (en) * 1994-04-12 2000-08-15 Smoke-Stop Breath activated inhaler
US5568807A (en) * 1994-06-10 1996-10-29 Mecikalski; Mark B. Air-flow control for an inhaler
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US6055979A (en) * 1996-04-02 2000-05-02 Ing. Erich Pfeiffer Gmbh Dosing and discharging device for flowable media including powder/air dispersions
US6095136A (en) * 1997-03-14 2000-08-01 Astra Aktiebolag Inhalation device
WO1999013930A1 (en) * 1997-09-18 1999-03-25 Glaxo Group Limited Intranasal administration device
US6234169B1 (en) * 1998-08-14 2001-05-22 Arthur Slutsky Inhaler
WO2004012802A1 (en) * 2002-08-05 2004-02-12 Budai Laszlo Inhaler apparatus for mitigating respiratory complaints
WO2009134157A2 (en) * 2008-03-26 2009-11-05 S.C. Medical Pharma Salt S.R.L. Inhaler
WO2009134157A3 (en) * 2008-03-26 2009-12-23 S.C. Medical Pharma Salt S.R.L. Inhaler
USD642330S1 (en) 2009-10-26 2011-07-26 Jeffrey Turner Delivery device
US9050431B2 (en) 2010-10-18 2015-06-09 Jeffrey turner Device for dispensing a medium
US9545489B2 (en) 2010-10-18 2017-01-17 Jeffrey Turner Device for dispensing a medium
US11471623B2 (en) 2012-02-21 2022-10-18 Respira Therapeutics, Inc. Powder dispersion methods and devices
US20150314086A1 (en) * 2012-02-21 2015-11-05 Respira Therapeutics, Inc. Powder inhaler, system and methods
US10682476B2 (en) * 2012-02-21 2020-06-16 Respira Therapeutics, Inc. Powder inhaler, system and methods
US10525216B2 (en) 2012-02-21 2020-01-07 Respira Therapeutics, Inc. Powder dispersion methods and devices
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
JP2015521526A (en) * 2012-06-25 2015-07-30 レスピラ セラピューティクス インコーポレイテッドRespira Therapeutics,Inc. Powder dispersion device and method
EP3110484A4 (en) * 2014-02-21 2018-02-14 Respira Therapeutics, Inc. Powder inhaler, system and methods
CN106794325A (en) * 2014-02-21 2017-05-31 瑞必治公司 Powder inhalator, system and method
CN106794325B (en) * 2014-02-21 2020-06-30 瑞必治公司 Powder inhaler, system and method
JP2018501903A (en) * 2015-01-14 2018-01-25 レスピラ セラピューティクス インコーポレイテッドRespira Therapeutics,Inc. Powder dispersion method and apparatus
CN107427650A (en) * 2015-01-14 2017-12-01 瑞必治公司 Powder process for dispersing and device

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