US20160101130A1 - Silver nanoplate compositions and methods - Google Patents
Silver nanoplate compositions and methods Download PDFInfo
- Publication number
- US20160101130A1 US20160101130A1 US14/974,987 US201514974987A US2016101130A1 US 20160101130 A1 US20160101130 A1 US 20160101130A1 US 201514974987 A US201514974987 A US 201514974987A US 2016101130 A1 US2016101130 A1 US 2016101130A1
- Authority
- US
- United States
- Prior art keywords
- silver
- solution
- nanoplates
- silver nanoplates
- optical density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 127
- 238000000034 method Methods 0.000 title claims abstract description 48
- 239000002055 nanoplate Substances 0.000 title abstract description 47
- 239000004332 silver Substances 0.000 title abstract description 36
- 229910052709 silver Inorganic materials 0.000 title abstract description 36
- 239000000203 mixture Substances 0.000 title description 5
- 230000003287 optical effect Effects 0.000 claims abstract description 67
- 239000013043 chemical agent Substances 0.000 claims abstract description 26
- 230000008569 process Effects 0.000 claims abstract description 14
- 230000000087 stabilizing effect Effects 0.000 claims description 15
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 239000002243 precursor Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 abstract description 106
- 239000000758 substrate Substances 0.000 abstract description 36
- 239000003381 stabilizer Substances 0.000 abstract description 29
- 239000002105 nanoparticle Substances 0.000 abstract description 22
- 239000003124 biologic agent Substances 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000009295 crossflow filtration Methods 0.000 description 19
- 239000002245 particle Substances 0.000 description 16
- 229920000642 polymer Polymers 0.000 description 13
- 238000001228 spectrum Methods 0.000 description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 description 10
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 10
- 239000002202 Polyethylene glycol Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 239000012528 membrane Substances 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- 230000008033 biological extinction Effects 0.000 description 8
- 125000000524 functional group Chemical group 0.000 description 7
- 230000003595 spectral effect Effects 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- -1 nanocubes Substances 0.000 description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 150000003573 thiols Chemical class 0.000 description 5
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 150000001345 alkine derivatives Chemical class 0.000 description 4
- 150000001540 azides Chemical class 0.000 description 4
- 229960002685 biotin Drugs 0.000 description 4
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011616 biotin Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000002131 composite material Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 239000002077 nanosphere Substances 0.000 description 4
- 229920002492 poly(sulfone) Polymers 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical class C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 3
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- 239000002250 absorbent Substances 0.000 description 3
- 230000002745 absorbent Effects 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000004323 axial length Effects 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000006172 buffering agent Substances 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000007799 cork Substances 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052752 metalloid Inorganic materials 0.000 description 3
- 150000002738 metalloids Chemical class 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 229910000077 silane Inorganic materials 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 239000001263 FEMA 3042 Substances 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 2
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 238000003917 TEM image Methods 0.000 description 2
- 238000002679 ablation Methods 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229920002258 tannic acid Polymers 0.000 description 2
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 2
- 229940033123 tannic acid Drugs 0.000 description 2
- 235000015523 tannic acid Nutrition 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- AGBXYHCHUYARJY-UHFFFAOYSA-N 2-phenylethenesulfonic acid Chemical compound OS(=O)(=O)C=CC1=CC=CC=C1 AGBXYHCHUYARJY-UHFFFAOYSA-N 0.000 description 1
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
- 241001481789 Rupicapra Species 0.000 description 1
- 108010046516 Wheat Germ Agglutinins Proteins 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000746 body region Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001719 carbohydrate derivatives Chemical group 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 239000002577 cryoprotective agent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 150000004662 dithiols Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002073 nanorod Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 108010087904 neutravidin Proteins 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229940006186 sodium polystyrene sulfonate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000000352 supercritical drying Methods 0.000 description 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/05—Metallic powder characterised by the size or surface area of the particles
- B22F1/054—Nanosized particles
- B22F1/0545—Dispersions or suspensions of nanosized particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/05—Metallic powder characterised by the size or surface area of the particles
- B22F1/054—Nanosized particles
- B22F1/0551—Flake form nanoparticles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/14—Treatment of metallic powder
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/14—Treatment of metallic powder
- B22F1/145—Chemical treatment, e.g. passivation or decarburisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/14—Treatment of metallic powder
- B22F1/145—Chemical treatment, e.g. passivation or decarburisation
- B22F1/147—Making a dispersion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/16—Metallic particles coated with a non-metal
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G5/00—Compounds of silver
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/20—Compounding polymers with additives, e.g. colouring
- C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
- C08J3/2053—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase the additives only being premixed with a liquid phase
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
- C08K3/08—Metals
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/28—Nitrogen-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/34—Silicon-containing compounds
- C08K3/36—Silica
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/38—Boron-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
- C08K5/092—Polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/15—Heterocyclic compounds having oxygen in the ring
- C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
- C08K5/1535—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D125/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Coating compositions based on derivatives of such polymers
- C09D125/02—Homopolymers or copolymers of hydrocarbons
- C09D125/04—Homopolymers or copolymers of styrene
- C09D125/06—Polystyrene
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D129/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Coating compositions based on hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Coating compositions based on derivatives of such polymers
- C09D129/02—Homopolymers or copolymers of unsaturated alcohols
- C09D129/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D139/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Coating compositions based on derivatives of such polymers
- C09D139/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C09D139/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/06—Metallic powder characterised by the shape of the particles
- B22F1/068—Flake-like particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F2301/00—Metallic composition of the powder or its coating
- B22F2301/25—Noble metals, i.e. Ag Au, Ir, Os, Pd, Pt, Rh, Ru
- B22F2301/255—Silver or gold
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F2998/00—Supplementary information concerning processes or compositions relating to powder metallurgy
- B22F2998/10—Processes characterised by the sequence of their steps
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2325/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Derivatives of such polymers
- C08J2325/18—Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
- C08J2329/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
- C08K3/08—Metals
- C08K2003/0806—Silver
Definitions
- Various embodiments of the invention relate to methods for preparing high optical density solutions of silver platelet nanoparticles (e.g., nanoplates) and to nanoparticles, solutions and substrates prepared by said methods.
- silver platelet nanoparticles e.g., nanoplates
- Nanoparticles including nanospheres, nanorods, nanowires, nanocubes, nanoplates, as well as other shapes can be synthesized from a range of materials.
- Nanoparticles made from metals including gold and silver have unique optical properties which can be tuned to interact with light throughout the electromagnetic spectrum due to the localized surface plasmon resonance supported by these nanomaterials.
- Technologies that take advantage of the unique optical properties of silver nanoparticles, include, but are not limited to, diagnostic, photonic, medical, and obscurant technologies. A subset of these technologies including photothermal tumor ablation, hair removal, acne treatment, wound healing, and antimicrobial applications among others, may use solutions of nanoparticles with high optical densities.
- Silver platelet nanoparticles which are also known as silver nanoplates or silver nanoprisms, are of particular interest for technologies that utilize nanoparticle optical properties due to their tunable spectral peaks and extremely high optical efficiencies. While methods to fabricate silver platelet nanoparticles via photoconversion (Jin et al. 2001; Jin et al. 2003), pH-controlled photoconversion (Xue 2007), thermal growth (Hao et al. 2004; Hao 2002; He 2008; Metraux 2005), templated growth (Hao et al. 2004; Hao 2002), and seed mediated growth (Aherne 2008; Chen; Carroll 2003; Chen; Carroll 2002, 2004; Chen et al.
- a more concentrated solution of the silver nanoplates is of utility and can be particularly advantageous.
- the shape of the particle can undergo a change resulting in a shift in the solution optical properties. In many cases, these changes result in an undesirable degradation of their optical properties.
- several embodiments of the present invention provide methods for preparing high optical density solutions of silver nanoplates from dilute silver nanoplate solutions that substantially or fully preserve the optical properties of as-fabricated silver nanoplates when the particle concentration is increased.
- the high optical density solutions of silver nanoplates can be exposed to substrates to generate nanoplate composites with high loading levels.
- the process comprises the replacement of one or more original components (e.g., chemical or biological agents) bound, or otherwise coupled to, the nanoparticle surface with a stabilizing agent.
- the stabilizing agent can be a biological or chemical agent that stabilizes the nanoplates before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates.
- the process also comprises a method of increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.
- the stability e.g., the characteristics of the nanoparticles in the solution, such as shape, size, optical properties, peak response, plasmonic properties, etc.
- the stability is unaffected or substantially unaffected during the process.
- a high optical density solution comprises silver nanoplates that have been stabilized with stabilizing agents (e.g., surface bound molecules chemical agents, and/or biological agents).
- stabilizing agents e.g., surface bound molecules chemical agents, and/or biological agents.
- a solution of silver platelet nanoparticles e.g., silver nanoplates
- a high optical density solution of silver nanoplates is associated with a substrate.
- a portion of the nanoplates in solution bind to the substrate to create a nanoplate-substrate composite.
- the high optical density solutions of silver nanoplates can be exposed to substrates to generate nanoplate composites where a substantial portion of the surface area of a substrate is coated with nanoplates.
- the substrate comprises fibers, cloth, mesh, bandages, socks, wraps, other articles of clothing, sponges, high porosity substrates, particles with edge lengths greater than 1 micron, beads, hair, skin, paper, absorbent polymers, foam, wood, cork, slides, roughened surfaces, biocompatible substrates, filters, and/or medical implants.
- a process for increasing the optical density of a solution of stable, silver nanoplates comprises the following: (i) providing a solution comprising silver nanoplates having a plate shape, a first extinction spectra, and a first peak optical density between 0.1-10 cm ⁇ 1 ; (ii) adding a concentration stabilizing chemical agent to the solution of silver nanoplates; and (iii) increasing the concentration of silver nanoplates using tangential flow filtration, thereby increasing the optical density of the solution to a second peak optical density greater than 10 cm ⁇ 1 , wherein the silver nanoplates comprise the plate shape and the first extinction spectra at the optical density greater than 10 cm ⁇ 1 .
- the stabilizing agent comprises or consists essentially of at least one of the group consisting of polyvinyl pyrollidone, polyvinyl alcohol, polyethylene glycol, and dextran. In various embodiments, the stabilizing agent comprises or consists essentially of at least one of the group consisting of polysulphonates, ethylene oxides, phenols, and carbohydrates.
- the concentration stabilizing chemical agent is a water soluble polymer. In one embodiment, the concentration stabilizing chemical agent is a metal or metalloid oxide.
- the stabilizing chemical agent is a silicon dioxide shell. In various embodiment, the silicon dioxide shell ranges in thickness from 1 nm to 100 nm. In one embodiment, the stabilizing chemical agent is a titanium dioxide shell. In various embodiments, a combination of stabilizing agents are used.
- the process further comprises adding any of the group selected from an acid, a base, and a buffering agent to the solution.
- the silver nanoplates have an aspect ratio of between 1.5 and 25.
- the nanoplate has an edge length between 10 nm and 250 nm.
- the solution of silver nanoplates is formed using a seed mediated growth method.
- the concentration of silver nanoplates is washed with between 1 and 5 wash volumes after increasing the concentration using tangential flow filtration.
- the solution of silver nanoplates is incubated with a substrate.
- a process for generating a solution of silver nanoplates with high optical density comprises the following: (i) providing a solution of silver nanoplates with a first peak optical density between 0.1-10 cm ⁇ 1 , (ii) adding a concentration stabilizing chemical agent to the solution of silver nanoplates; (iii) adding a buffer to the solution of silver nanoplates; and (iv) increasing the concentration of the silver nanoplates to increase the optical density of the solution greater than 10 cm ⁇ 1 .
- the concentration stabilizing chemical agent comprises a derivative of a vinyl polymer.
- the polymer is polyvinyl alcohol (PVA).
- the polymer is polyvinyl pyrrolidone (PVP).
- the process further comprises adding one of the group consisting of sodium bicarbonate and sodium borate to the solution.
- a process for generating a solution of silver nanoplates with extremely high optical density comprises the following: (i) adding a concentration stabilizing chemical agent to a solution of silver nanoplates or precursor reagents and (ii) increasing the concentration of silver nanoplates to increase the optical density of the solution.
- the silver nanoplates have an aspect ratio of between 1.5 and 25 (e.g., 1.5-10, 25-50); and/or the nanoplate has an edge length between about 10 nm and 250 nm (e.g., 50-250, 65-100 nm); and/or the nanoplate is triangular in cross section; and/or the nanoplate is circular in cross section.
- the perimeter of the nanoplate cross section has between 4 and 8 edges (e.g., 4, 5, 6, 7, 8).
- the solution of silver nanoplates is formed using one or more of a photoconversion method, a pH-controlled photoconversion method, a thermal growth method, a seed mediated growth method, and/or a solution comprising a shape stabilizing agent or agents and a silver source.
- chemical or biological agents, and/or electromagnetic radiation, and/or heat, or a combination thereof are used to reduce the silver source.
- the solution of silver nanoplates is formed from some combination of a reducing agent, a shape stabilizing agent, a light source, a heat source, and a silver source.
- an acid, base, or buffering agent is added to change the solution pH.
- the concentration stabilizing chemical agent is added prior to, during, and/or after the formation of the silver nanoplates.
- the concentration stabilizing chemical agent acts as a shape stabilizing agent.
- the concentration stabilizing chemical agent acts as a reducing agent.
- the concentration stabilizing chemical agent acts as an agent to change the solution pH.
- the concentration stabilizing chemical agent is a water soluble polymer.
- the polymer is any one or more of a derivative of polysulfonate, sodium polystyrene sulfonate, a derivative of a vinyl polymer, and a polyvinyl alcohol (PVA).
- the PVA has a molecular weight of less than about 80,000 Dalton (e.g., 1,000-50,000, 25,000-75,000 Dalton), between about 80,000 Dalton and 120,000 Dalton (e.g., 85,000-95,000, 100,000-110,000 Dalton), and/or more than about 120,000 Dalton (e.g., 150,000-300,000 Dalton).
- the polymer is polyvinylpyrrolidone (PVP).
- PVP polyvinylpyrrolidone
- the PVP has a molecular weight of less than about 20,000 Dalton (e.g., 2,000-12,000 Dalton), more than about 20,000 Dalton (e.g., 35,000-400,000 Dalton), between about 20,000 Dalton and 60,000 Dalton (e.g., 40,000-55,000 Dalton), and/or more than about 60,000 Dalton (e.g., 70-100,000, 90-150,000 Dalton).
- the polymer is an ethylene oxide derivative.
- the polymer is a polyethylene glycol (PEG).
- the PEG has a molecular weight of less than about 5,000 Dalton (e.g., 200-3,000, 1,000-4,500 Dalton), between about 5,000 Dalton and 10,000 Dalton (e.g., 7,000-8,000, 6,000-7,500 Dalton), and/or more than about 10,000 Dalton (e.g., 12,000-35,000, 18,000-45,000 Dalton).
- the PEG contains a single functional group.
- the PEG contains more than one functional group (e.g., two, three, or more functional groups).
- the functional group or groups comprise any of an amine, thiol, acrylate, alkyne, maleimide, silane, azide, hydroxyl, lipid, disulfide, fluorescent molecule, and/or biotin.
- the functional group or groups can be any one or more of an amine, thiol, acrylate, alkyne, maleimide, silane, azide, hydroxyl, lipid, disulfide, fluorescent molecule, and/or biotin.
- the concentration stabilizing agent is a carbohydrate derivative.
- the polymer is a monosaccharide, a disaccharide, an oligosaccharide, a polysaccharide, and/or dextran.
- the dextran has a molecular weight that is less than about 2,000 Dalton (e.g., 200-1,400, 1,000-1,900 Dalton), between about 2,000 Dalton and 5,000 Dalton (e.g., 3,000-3,500, 2,000-4,000 Dalton), and/or more than about 5,000 Dalton (e.g., 6,000-8,000, 7,000-13,000 Dalton).
- the concentration stabilizing chemical agent is any one or more of a phenol, a monomeric phenol, a dimeric phenol, a trimeric phenol, a polyphenol, a tannic acid, is gum Arabic, a biological molecule, a protein, a bovine serum albumin, streptavidin, biotin, a peptide, an oligonucleotide, a naturally occurring oligonucleotide, a synthetic oligonucleotide, a metal or metalloid oxide, and/or a silicon dioxide shell.
- a silicon dioxide shell has ranges in thickness from about less than 1 nm to about 100 nm (e.g., 10-70, 30-90, 40-60 nm).
- a combination of stabilizing agents are used.
- the solvent can be one or more of water, an alcohol, ethanol, isopropyl alcohol, t-butanol, a mixture of a water and an alcohol.
- the concentration of silver nanoplates is increased using tangential flow filtration.
- the tangential flow filtration is performed using a tangential flow filter membrane.
- the tangential flow membrane is made from a cellulose ester or mix of cellulose esters.
- the tangential flow membrane is made from one or more of polyetheresulfone and/or polysulfone.
- the tangential flow membrane has a molecular weight cut off of less than about 10 kD (e.g., 1-5, 8 kD), of between about 10 kD and 500 kD (e.g., 50-250, 300-400 kD), of more than about 500 kD (e.g., 750, 1000, 5000 kD or more), of less than about 0.05 ⁇ m, of between about 0.05 ⁇ m and 0.5 ⁇ m (e.g., 0.01, 0.03 ⁇ m), and/or of more than about 0.5 ⁇ m (e.g., 1.0, 2, 5, 10, 100 ⁇ m).
- a molecular weight cut off less than about 10 kD (e.g., 1-5, 8 kD), of between about 10 kD and 500 kD (e.g., 50-250, 300-400 kD), of more than about 500 kD (e.g., 750, 1000, 5000 kD or more), of less than about 0.05
- the silver nanoplate solution is concentrated to produce a solution with an optical density of greater than about 10 cm ⁇ 1 (e.g., 15-45 cm ⁇ 1 , 30-150 cm ⁇ 1 , or more), greater than about 50 cm ⁇ 1 (e.g., 80-150 cm ⁇ 1 , 60-120 cm ⁇ 1 , 100 cm ⁇ 1 or more), greater than about 75 cm ⁇ 1 (e.g., 80-110 cm ⁇ 1 , 200-400 cm ⁇ 1 , 1000 cm ⁇ 1 or more), greater than about 100 cm ⁇ 1 (e.g., 150-350 cm ⁇ 1 , 200-400 cm ⁇ 1 or more), and/or greater than about 500 cm ⁇ 1 (e.g., 600-1500 cm ⁇ 1 , 1000 cm ⁇ 1 or more).
- an optical density greater than about 10 cm ⁇ 1 (e.g., 15-45 cm ⁇ 1 , 30-150 cm ⁇ 1 , or more), greater than about 50 cm ⁇ 1 (e.g., 80-150
- the solvent of the concentrated solution is exchanged using tangential flow filtration.
- the concentrated solution is processed to remove residual chemicals using tangential flow filtration.
- a solution of nanoparticles comprising silver nanoparticles is coated with a polymer with an optical density greater than 100 cm ⁇ 1 (e.g., 160-550 cm ⁇ 1 , 900-1100 cm ⁇ 1 , 100 cm ⁇ 1 , 1000 cm ⁇ 1 or more).
- the solution of silver nanoplates is incubated with a substrate (e.g., fibers, cloth, mesh, bandages, socks, wraps, other articles of clothing, sponges, high porosity substrates, particles with edge lengths greater than 1 micron, beads, hair, skin, paper, absorbent polymers, foam, wood, cork, slides, roughened surfaces, biocompatible substrates, filters, and/or medical implants).
- a substrate e.g., fibers, cloth, mesh, bandages, socks, wraps, other articles of clothing, sponges, high porosity substrates, particles with edge lengths greater than 1 micron, beads, hair, skin, paper, absorbent polymers, foam, wood, cork, slides, roughened surfaces, biocompatible substrates, filters, and/or medical implants.
- the substrate is removed from the solution of silver nanoplates and dried.
- FIG. 1 illustrates the optical spectrum of a silver nanoplate solution as fabricated using a photoconversion method according to one embodiment of the present invention.
- a silver nanoplate solution is fabricated using a photoconversion method identified as [DSS1099, alternative spectrum ARS1134]—as fabricated, these silver nanoplates have an optical density of less than 1 cm ⁇ 1 .
- FIG. 2 illustrates a transmission electron micrograph of silver nanoplates fabricated using a photoconversion method according to one embodiment of the present invention.
- Scale bar is 50 nm.
- FIG. 3 illustrates one embodiment of plates concentrated in the absence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration. After concentration the plates have a significantly changed peak shape as demonstrated by the normalized plot, and a spectral peak at 400 nm that demonstrates that a large number of silver nanoplates have turned into silver nanospheres.
- plates are concentrated with the identification [MGM1201 and 1195E].
- FIG. 4 illustrates one embodiment of plates concentrated in the presence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration using a concentration stabilizing agent. After being concentrated the plates retain their spectral peak shape with no increase in the spectral peak at 400 nm. In one embodiment, plates are concentrated with the identification [MGM1282 and 1279A].
- FIG. 5 illustrates extinction spectra of high optical density nanoplate solutions processed using the methods described in various embodiments of the invention.
- the optical density is a function of the path length through the liquid sample is expressed in units of cm ⁇ 1 . In some instances, optical density is expressed without the unit cm ⁇ 1 —such as in instances in which a standard path length of 1 cm is used.
- silver nanoplates are characterized by lengths along the three principle axes wherein: the axial length of two of the principle axes is at least two times greater than the axial length of the shortest principle axis and the shortest principal axial length is less than about 500 nm.
- the ratio of the average of the two longer principle axes to the shorter principle axes is referred to as the aspect ratio.
- the average aspect ratio of the silver plates is greater than 1.5, 2, 3, 4, 5, 7, 10, 20, 30, or 50, or any range therein (e.g., greater than 8, 9, 11, 12, 13, 14, 15, 25, 35, 40, 45).
- the average aspect ratio of the silver plates is between 1.5 and 25, 2 and 25, 1.5 and 50, 2 and 50, 3 and 25, or 3 and 50 (e.g., 5 and 20, 10 and 15, 5 and 40, 5 and 30, 5 and 20, 10 and 50, 20 and 50, 30 and 50, 40 and 50, 10 and 20, 20 and 30, 30 and 40, 40 and 50, and any values between 1.5 and 50, inclusive).
- the nanoplate has edge lengths less than 500 nm, 250 nm, 200 nm, 150 nm, 100 nm, 80 nm, 60 nm or 50 nm (e.g., 400 nm, 300 nm, 225 nm, 175 nm, 125 nm, 90 nm, 70 nm, 55 nm, and any values between 500 and 50 nm, inclusive).
- the nanoplate has edge lengths greater than 5 nm, 10 nm, 20 nm, 30 nm, 50 nm or 100 nm, or any value therein or more (e.g., 15, 25, 40, 60, 70 75, 80, 90, 5-100, 20-80, 30-50, 45-95 nm, and/or 30 nm to 100 nm, 20 nm to 150 nm, 10 nm to 200 nm, 10 nm to 300 nm).
- the nanoplate has a thickness (third principle axis) that is less than 500 nm, 300 nm, 200 nm, 100 nm, 80 nm, 60 nm, 50 nm, 40 nm, 30 nm, 20 nm, or 10 nm, or any value therein (e.g., 400 nm, 250 nm, 150 nm, 75 nm, 5 nm to 20 nm, 5 nm to 30 nm, 10 nm to 30 nm, 10 nm to 50 nm, 10 nm to 100 nm).
- Silver nanoplates have a variety of different cross sectional shapes including circular, triangular, or shapes that have any number of discrete edges. In one embodiment the nanoplates have less than 20, 15, 10, 8, 6, 5, or 4 edges (e.g., 18, 12, 11, 9, 2, 1). In one embodiment the nanoplates have more than 2, 3, 4, or 5 edges (e.g., 6, 7, 10, 15, 20 or more). In some embodiments the silver nanoplates have sharp corners and in other embodiments the corners are rounded. In some embodiments of silver nanoplates, there are a variety of different cross sectional shapes within the same sample.
- silver nanoplate solutions greater than 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the number of particles in solution are silver nanoplates with the other particles having different shapes including but not limited to spherical, cubic, and irregular.
- the nanoplates have one or two flat sides.
- the nanoplates are pyramidal.
- the silver nanoplates utilized in various embodiments of this invention may be fabricated using photoconversion (Jin et al. 2001; Jin et al. 2003), pH controlled photoconversion (Xue 2007), thermal growth (Hao et al. 2004; Hao 2002; He 2008; Metraux 2005), templated growth (Hao et al. 2004; Hao 2002), seed mediated growth (Aherne 2008; Chen; Carroll 2003; Chen; Carroll 2002, 2004; Chen et al. 2002; He 2008; Le Guevel 2009; Xiong et al. 2007), or alternative methods.
- Alternative methods include methods in which the silver nanoplates are formed from a solution comprising a shape stabilizing agent or agents and a silver source, and in which chemical agents, biological agents, electromagnetic radiation, or heat are used to reduce the silver source.
- FIG. 1 illustrates the optical spectrum of a silver nanoplate solution as fabricated using a photoconversion method according to one embodiment of the present invention.
- a silver nanoplate solution is fabricated using a photoconversion method identified as [DSS1099, alternative spectrum ARS1134]—as fabricated, these silver nanoplates have an optical density of less than 1 cm ⁇ 1 .
- FIG. 2 illustrates a transmission electron micrograph of silver nanoplates fabricated using a photoconversion method according to one embodiment of the present invention.
- the scale bar is 50 nm.
- FIG. 3 illustrates one embodiment of plates concentrated in the absence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) optical extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration. After concentration the plates have a significantly changed peak shape as demonstrated by the normalized plot, and a spectral peak at 400 nm that demonstrates that a large number of silver nanoplates have turned into silver nanospheres.
- plates are concentrated with the identification [MGM1201 and 1195E].
- FIG. 4 illustrates one embodiment of plates concentrated in the presence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) optical extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration using a concentration stabilizing agent. After being concentrated the plates retain their spectral peak shape with no increase in the spectral peak at 400 nm. In one embodiment, plates are concentrated with the identification [MGM1282 and 1279A].
- FIG. 5 illustrates optical extinction spectra of high optical density nanoplate solutions processed using the methods described in various embodiments of the invention.
- silver nanoplates have molecules that are adsorbed or otherwise bound to the particle surface.
- the molecules on the surface are the reactants or reactant by-products of the synthesis.
- One object of one embodiment of this invention is to partially or fully exchange the molecules that are bound to the surface of the silver nanoplates with other molecules that more fully protect the particles from changing shape during concentration.
- Another object of one embodiment of the invention is to use a stabilizing agent during fabrication that generates plate shapes and also stabilizes the nanoplates during subsequent concentration.
- stabilizing agent variants that may be utilized include chemical or biological agents that are physisorbed to the surface, molecularly bound to the surface through specific interactions (e.g. thiol or amine), or encapsulate the surface (i.e. a metal oxide or metalloid oxide shell).
- specific chemical agents of interest include polymers such as polysulphonates, vinyl polymers, carbohydrates, ethylene oxides, phenols, and carbohydrates.
- polystyrene sulfonate examples include poly(sodium) styrene sulfonate, polyvinyl alcohol, polyvinyl pyrrolidone, tannic acid, dextran, and polyethylene glycol (PEG) including PEG molecules which contain one or more chemical groups (e.g. amine, thiol, acrylate, alkyne, maleimide, silane, azide, hydroxyl, lipid, disulfide, fluorescent molecule, or biomolecule moieties).
- PEG polyethylene glycol
- biomolecules of interest include proteins, peptides, and oligonucleotides, including biotin, bovine serum albumin, streptavidin, neutravidin, wheat germ agglutinin, naturally occurring and synthetic oligonucleotides and peptides, including synthetic oligonucleotides which have one or more chemical functionalities (e.g. amine, thiol, dithiol, acrylic phosphoramidite, azide, digoxigenin, alkynes, or biomolecule moieties).
- Specific encapsulating chemical agents of interest include metal oxide shells such as SiO 2 and TiO 2 . Stabilizing agents may be added prior to the formation of silver nanoplates, during the formation of silver nanoplates, or after the formation of silver nanoplates.
- An additional chemical agent of interest is gum arabic.
- the silver nanoplates are fabricated in aqueous solutions. In other embodiments the silver nanoplates are fabricated in other solutions that can include ethanol, isopropanol, or organic solvents such as heptane, toluene, or butanol.
- an acid, base or buffering agent e.g., a buffer
- a buffer e.g., a buffer
- the nanoplates are suspended in a sodium bicarbonate buffer or a sodium borate buffer.
- stabilizing agents can be solid or liquid formulations that are added to the silver plate solution.
- the stabilizing agents have an affinity for the surface of the silver nanoplates and will associate with the plate surface.
- the bound molecules on the silver nanoplates will be displaced by the added stabilizing agents.
- the stabilants are added to the as-fabricated silver nanoplate solution.
- the solution of nanoplates is washed, or the residual reactants are otherwise removed.
- the suspending solution is exchanged with a different suspending media which includes ethanol, isopropanol, or other polar or non-polar liquids before the stabilizing agents are added.
- the mixture of the stabilant and the silver nanoplates can undergo a number of different processes including heating, boiling, boiling under reflux, rotoevaporation, vacuum, stirring, stirring with magnetic stir bars, stirring with overhead mixers, stirring with homogenizers, shaking, microfluidization, refrigeration, and freezing.
- the silver nanoplates can be washed to remove residual reactants or to exchange the solution with another solution.
- the exchange of solution can be accomplished using dialysis, centrifugation, filtration, or tangential flow filtration.
- One embodiment of the invention is where the number of wash volumes exchanged within the sample is 1, 2, 3, 4, 5, between 1 and 5, between 5 to 10, between 10 to 20, or more than 20 wash volumes.
- High optical density solutions of the nanoparticles can be fabricated using centrifugation, evaporation, filtration, dialysis or tangential flow filtration.
- One embodiment of this invention utilizes tangential flow filtration as the process of concentrating the silver nanoplate solution.
- the filter membrane utilized may be formed from a variety of materials. Specific filter membrane materials of interest include cellulose esters, polysulfone, and polyetheresulfone.
- the filter membrane utilized may have pores with a molecular weight cutoff of less than about 10 kD, between 10 kD to 500 kD, or more than about 500 kD (e.g., between 10 kD, to 100 kD, 10 kD to 500 kD, 20 kD to 500 kD, 20 kD to 250 kD), and/or pore sizes of less than about 0.05 ⁇ m, between 0.05 ⁇ m and 0.5 ⁇ m, or larger than about 0.5 ⁇ m (e.g., between 0.02 ⁇ m and 0.1 ⁇ m, 0.05 ⁇ m and 0.2 ⁇ m, 0.05 ⁇ m and 0.5 ⁇ m, 0.10 ⁇ m and 0.2 ⁇ m, 0.1 ⁇ m and 0.5 ⁇ m).
- Tangential flow filtration can also be utilized to change the solvent in which the silver nanoplates are dispersed.
- Specific solvents of interest include water and alcohols (e.g. t-butanol, ethanol, and isopropyl alcohol), as well as other polar or non-polar solvents. Additionally, tangential flow filtration can be utilized to remove residual chemicals.
- This invention includes embodiments in which the silver nanoplate solution concentration is increased to produce a final solution with optical densities of greater than about 5 cm ⁇ 1 , greater than about 10 cm ⁇ 1 , greater than about 50 cm ⁇ 1 , greater than about 75 cm ⁇ 1 , greater than about 100 cm ⁇ 1 , greater than about 500 cm ⁇ 1 , or greater than about 1000 cm ⁇ 1 (e.g., between 10 cm ⁇ 1 to 100 cm ⁇ 1 , 30 cm ⁇ 1 to 300 cm ⁇ 1 , 50 cm ⁇ 1 to 500 cm ⁇ 1 , 100 cm ⁇ 1 to 1000 cm ⁇ 1 , 300 cm ⁇ 1 to 3000 cm ⁇ 1 , or 500 cm ⁇ 1 to 5000 cm ⁇ 1 )
- One embodiment of the invention is where the silver nanoplate solution concentration is increased to above 10 6 , 10 7 , 10 8 , 10 9 , 10 10 , 10 11 , 10 12 , 10 13 particles per milliliter.
- One embodiment of the invention is where the concentrated particles are stored at temperatures below ⁇ 10, 0, 4, 6, 10, or 20 degrees C.
- One embodiment of the invention is where the particles are frozen and dried under vacuum. One embodiment is where the particles are freeze dried. One embodiment is where the particles are supercritically dried. Another embodiment is where an additional stabilant or other cryoprotectant is added to the solution before the particles are heat dried or freeze dried.
- high optical density solutions of silver nanoplates are associated with a substrate.
- substrates include fibers, cloth, mesh, bandages, socks, wraps, other articles of clothing, sponges, high porosity substrates, particles with diameters greater than 1 micron, beads, hair, skin, paper, absorbent polymers, foam, wood, cork, slides, roughened surfaces, biocompatible substrates, filters, or medical implants.
- the high optical density solutions of silver nanoplates at a concentration of at least 1 mg/mL, 10 mg/mL, 100 mg/mL are incubated with the substrate.
- the high optical density solutions of silver nanoplates at a concentration of at least 1 mg/mL, 10 mg/mL, or 100 mg/mL are incubated with the substrate.
- the silver nanoplates are prepared at an optical density of at least 10, 100, 300, 500, 1000, or 2000 cm ⁇ 1 (e.g., between 10-100, 20-200, 30-300, 50-500, 100-1000, 200-1000, 300-1000, 500-1000, or 200-2000 cm ⁇ 1 ) before incubating with the substrate.
- the substrate is chemically treated to increase the binding of the nanoplates to the substrate.
- the substrate could be functionalized with a molecule that yielded a positively or negatively charged surface.
- the pH of the incubating solution is selected in order to optimize binding.
- the silver nanoplates cover at least 5%, 10%, 20%, 30%, 50% or 75% of the substrate (e.g., 5% to 10%, 10% to 100%, 10% to 50%, 50% to 100%, 30% to 100%, 30% to 70%, 40% to 80%, 50% to 90%, 60% to 100%, 70% to 100%, 80% to 100%, 90% to 100%, 0% to 5%, 1% to 10%, 2% to 20%, 5% to 30%, and/or 1% to 50% of the substrate).
- the incubation is for less than 1 minute, 5 minutes, 20 minutes, 60 minutes, or 120 minutes (e.g., 0 to 1 minute, 1 minute to 120 minutes, 5 minutes to 120 minutes, 20 minutes to 120 minutes, 60 minutes to 120 minutes, 5 minutes to 60 minutes, 10 minutes to 60 minutes, 20 minutes to 60 minutes, 0 minutes to 10 minutes, 0 minutes to 20 minutes, or 0 minutes to 5 minutes).
- a biological linker e.g. antibodies, peptides, DNA
- the incubation is for less than 1 minute, 5 minutes, 20 minutes, 60 minutes, or 120 minutes (e.g., 0 to 1 minute, 1 minute to 120 minutes, 5 minutes to 120 minutes, 20 minutes to 120 minutes, 60 minutes to 120 minutes, 5 minutes to 60 minutes, 10 minutes to 60 minutes, 20 minutes to 60 minutes, 0 minutes to 10 minutes, 0 minutes to 20 minutes, or 0 minutes to 5 minutes).
- the substrate is separated from the incubating solution and dried.
- the substrate can be dried using air drying, heat drying, freeze drying, or supercritical drying.
- the dried substrate can be further processed by soaking the substrate in another material, painting the substrate with another material, or exposing the substrate to another material that is in the vapor phase.
- the methods disclosed herein include certain actions taken by a practitioner; however, they can also include any third-party instruction of those actions, either expressly or by implication. For example, actions such as “identifying a target region of skin tissue” include “instructing the identification of a target region of skin tissue.”
- ranges disclosed herein also encompass any and all overlap, sub-ranges, and combinations thereof.
- Language such as “up to,” “at least,” “greater than,” “less than,” “between,” and the like includes the number recited. Numbers preceded by a term such as “about” or “approximately” or “substantially” include the recited numbers. For example, “about 3 mm” includes “3 mm.”
- the terms “approximately”, “about” and/or “substantially” as used herein represent an amount or characteristic close to the stated amount or characteristic that still performs a desired function or achieves a desired result.
- the terms “approximately”, “about”, and “substantially” may refer to an amount that is within less than 10% of, within less than 5% of, within less than 1% of, within less than 0.1% of, and within less than 0.01% of the stated amount or characteristic.
- a method for increasing a silver nanoplate solution from 5 cm ⁇ 1 to 150 cm ⁇ 1 comprises the steps of adding PVA to silver nanoplates, and concentrating the solution with tangential flow filtration.
- 1.2 L of silver nanoplates with a peak optical density of about 4 cm ⁇ 1 were mixed with 4 L of anhydrous ethanol and about 49 mL of ammonium hydroxide solution.
- 0.6 mL of a dilute aminopropyltriethoxysilane (APTES) was added to the solution.
- 6.5 mL of tetraethylorthosilicate (TEOS) solution was added.
- 1 L of the solution was concentrated using a 500 kD polysulfone tangential flow membrane with 1050 cm 2 of surface area. The final solution volume was decreased to 150 mL, increasing the silver nanoparticle solution optical density to about 40 cm ⁇ 1 .
- APTES dilute aminopropyltriethoxysilane
- TEOS tetraethylorthosilicate
- a method for increasing a silver nanoplate solution from 4 cm ⁇ 1 to 40 cm ⁇ 1 comprises the steps of adding anhydrous ethanol, ammonium hydroxide solution, aminopropyltriethoxysilane (APTES), and tetraethylorthosilicate (TEOS) to the silver nanoplates, and concentrating the solution with tangential flow filtration.
- anhydrous ethanol ammonium hydroxide solution
- APTES aminopropyltriethoxysilane
- TEOS tetraethylorthosilicate
- a 40 mL solution of 40 O.D. solution of concentrated silver nanoplates was spun at 3000 RCF for 30 minutes. This processed was used to concentrate the silver nanoplates to an optical density of 1000 O.D.
- a 5 mL solution of 1000 OD silver nanoplates was added to a 3′′ ⁇ 3′′ section of absorbant cloth (Absorber Synthetic Drying Chamois, Clean Tools). After addition, the substrate was allowed to air dry. Once dried, the silver nanoplates were bound to the surface of the absorbant cloth and were not released when the cloth was subsequently wet and water removed by applying pressure.
Abstract
Description
- This application is a continuation of U.S. application Ser. No. 14/048,996 filed Oct. 8, 2013, which claims the benefit of priority from U.S. Provisional Application 61/795,149, filed on Oct. 11, 2012, each of which is incorporated by reference in its entirety. Any and all applications for which a foreign or domestic priority claim is identified in the Application Data Sheet as filed with the present application are hereby incorporated by reference under 37 CFR 1.57.
- 1. Field of the Invention
- Various embodiments of the invention relate to methods for preparing high optical density solutions of silver platelet nanoparticles (e.g., nanoplates) and to nanoparticles, solutions and substrates prepared by said methods.
- 2. Description of the Related Art
- Nanoparticles, including nanospheres, nanorods, nanowires, nanocubes, nanoplates, as well as other shapes can be synthesized from a range of materials. Nanoparticles made from metals including gold and silver have unique optical properties which can be tuned to interact with light throughout the electromagnetic spectrum due to the localized surface plasmon resonance supported by these nanomaterials. Technologies that take advantage of the unique optical properties of silver nanoparticles, (e.g., such as silver nanoplates), include, but are not limited to, diagnostic, photonic, medical, and obscurant technologies. A subset of these technologies including photothermal tumor ablation, hair removal, acne treatment, wound healing, and antimicrobial applications among others, may use solutions of nanoparticles with high optical densities. Silver platelet nanoparticles, which are also known as silver nanoplates or silver nanoprisms, are of particular interest for technologies that utilize nanoparticle optical properties due to their tunable spectral peaks and extremely high optical efficiencies. While methods to fabricate silver platelet nanoparticles via photoconversion (Jin et al. 2001; Jin et al. 2003), pH-controlled photoconversion (Xue 2007), thermal growth (Hao et al. 2004; Hao 2002; He 2008; Metraux 2005), templated growth (Hao et al. 2004; Hao 2002), and seed mediated growth (Aherne 2008; Chen; Carroll 2003; Chen; Carroll 2002, 2004; Chen et al. 2002; He 2008; Le Guevel 2009; Xiong et al. 2007) have been developed, these methods generate relatively dilute solutions with correspondingly low visible and near-infrared optical densities, (e.g., such as optical densities of less than 10 cm−1, such as 1-9 cm−1, 5-10 cm−1).
- For many silver nanoplate applications, a more concentrated solution of the silver nanoplates is of utility and can be particularly advantageous. In some instances, when the as-fabricated solutions of silver nanoplates are concentrated to yield a higher particle density under previously developed methods, the shape of the particle can undergo a change resulting in a shift in the solution optical properties. In many cases, these changes result in an undesirable degradation of their optical properties. Accordingly, several embodiments of the present invention provide methods for preparing high optical density solutions of silver nanoplates from dilute silver nanoplate solutions that substantially or fully preserve the optical properties of as-fabricated silver nanoplates when the particle concentration is increased. The high optical density solutions of silver nanoplates can be exposed to substrates to generate nanoplate composites with high loading levels.
- Various embodiments of the invention provide a method for preparing high optical density solutions of silver platelet nanoparticles, as well as the nanoparticles and solutions prepared by those methods. In one embodiment, the process comprises the replacement of one or more original components (e.g., chemical or biological agents) bound, or otherwise coupled to, the nanoparticle surface with a stabilizing agent. The stabilizing agent can be a biological or chemical agent that stabilizes the nanoplates before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. In one embodiment, the process also comprises a method of increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density. In several embodiments, the stability (e.g., the characteristics of the nanoparticles in the solution, such as shape, size, optical properties, peak response, plasmonic properties, etc.) of the high optical density solution is unaffected or substantially unaffected during the process.
- In one embodiment, a high optical density solution comprises silver nanoplates that have been stabilized with stabilizing agents (e.g., surface bound molecules chemical agents, and/or biological agents). In various embodiments, a solution of silver platelet nanoparticles (e.g., silver nanoplates) have been surface functionalized with chemical or biological agents that are physisorbed to the surface, molecularly bound to the surface through specific interactions, or encapsulate each nanoplate on its surface.
- In one embodiment, a high optical density solution of silver nanoplates is associated with a substrate. In one embodiment, a portion of the nanoplates in solution bind to the substrate to create a nanoplate-substrate composite. The high optical density solutions of silver nanoplates can be exposed to substrates to generate nanoplate composites where a substantial portion of the surface area of a substrate is coated with nanoplates. In some embodiments the substrate comprises fibers, cloth, mesh, bandages, socks, wraps, other articles of clothing, sponges, high porosity substrates, particles with edge lengths greater than 1 micron, beads, hair, skin, paper, absorbent polymers, foam, wood, cork, slides, roughened surfaces, biocompatible substrates, filters, and/or medical implants.
- In several embodiments, a process for increasing the optical density of a solution of stable, silver nanoplates comprises the following: (i) providing a solution comprising silver nanoplates having a plate shape, a first extinction spectra, and a first peak optical density between 0.1-10 cm−1; (ii) adding a concentration stabilizing chemical agent to the solution of silver nanoplates; and (iii) increasing the concentration of silver nanoplates using tangential flow filtration, thereby increasing the optical density of the solution to a second peak optical density greater than 10 cm−1, wherein the silver nanoplates comprise the plate shape and the first extinction spectra at the optical density greater than 10 cm−1.
- In various embodiments, the stabilizing agent comprises or consists essentially of at least one of the group consisting of polyvinyl pyrollidone, polyvinyl alcohol, polyethylene glycol, and dextran. In various embodiments, the stabilizing agent comprises or consists essentially of at least one of the group consisting of polysulphonates, ethylene oxides, phenols, and carbohydrates. In one embodiment, the concentration stabilizing chemical agent is a water soluble polymer. In one embodiment, the concentration stabilizing chemical agent is a metal or metalloid oxide. In one embodiment, the stabilizing chemical agent is a silicon dioxide shell. In various embodiment, the silicon dioxide shell ranges in thickness from 1 nm to 100 nm. In one embodiment, the stabilizing chemical agent is a titanium dioxide shell. In various embodiments, a combination of stabilizing agents are used.
- In various embodiments, the process further comprises adding any of the group selected from an acid, a base, and a buffering agent to the solution. In one embodiment, the silver nanoplates have an aspect ratio of between 1.5 and 25. In one embodiment, the nanoplate has an edge length between 10 nm and 250 nm. In some embodiments, the solution of silver nanoplates is formed using a seed mediated growth method. In one embodiment, the concentration of silver nanoplates is washed with between 1 and 5 wash volumes after increasing the concentration using tangential flow filtration. In one embodiment, the solution of silver nanoplates is incubated with a substrate.
- In various embodiments, a process for generating a solution of silver nanoplates with high optical density comprises the following: (i) providing a solution of silver nanoplates with a first peak optical density between 0.1-10 cm−1, (ii) adding a concentration stabilizing chemical agent to the solution of silver nanoplates; (iii) adding a buffer to the solution of silver nanoplates; and (iv) increasing the concentration of the silver nanoplates to increase the optical density of the solution greater than 10 cm−1.
- In one embodiment, the concentration stabilizing chemical agent comprises a derivative of a vinyl polymer. In one embodiment, the polymer is polyvinyl alcohol (PVA). In one embodiment, the polymer is polyvinyl pyrrolidone (PVP). In one embodiment, the process further comprises adding one of the group consisting of sodium bicarbonate and sodium borate to the solution.
- In several embodiments, a process for generating a solution of silver nanoplates with extremely high optical density comprises the following: (i) adding a concentration stabilizing chemical agent to a solution of silver nanoplates or precursor reagents and (ii) increasing the concentration of silver nanoplates to increase the optical density of the solution.
- In various embodiments, the silver nanoplates have an aspect ratio of between 1.5 and 25 (e.g., 1.5-10, 25-50); and/or the nanoplate has an edge length between about 10 nm and 250 nm (e.g., 50-250, 65-100 nm); and/or the nanoplate is triangular in cross section; and/or the nanoplate is circular in cross section. In one embodiment, the perimeter of the nanoplate cross section has between 4 and 8 edges (e.g., 4, 5, 6, 7, 8). In various embodiments, the solution of silver nanoplates is formed using one or more of a photoconversion method, a pH-controlled photoconversion method, a thermal growth method, a seed mediated growth method, and/or a solution comprising a shape stabilizing agent or agents and a silver source. In various embodiments, chemical or biological agents, and/or electromagnetic radiation, and/or heat, or a combination thereof are used to reduce the silver source. In one embodiment, the solution of silver nanoplates is formed from some combination of a reducing agent, a shape stabilizing agent, a light source, a heat source, and a silver source.
- In one embodiment, an acid, base, or buffering agent is added to change the solution pH. In various embodiments, the concentration stabilizing chemical agent is added prior to, during, and/or after the formation of the silver nanoplates. In one embodiment, the concentration stabilizing chemical agent acts as a shape stabilizing agent. In one embodiment, the concentration stabilizing chemical agent acts as a reducing agent. In one embodiment, the concentration stabilizing chemical agent acts as an agent to change the solution pH.
- In one embodiment, the concentration stabilizing chemical agent is a water soluble polymer. In various embodiments, the polymer is any one or more of a derivative of polysulfonate, sodium polystyrene sulfonate, a derivative of a vinyl polymer, and a polyvinyl alcohol (PVA). In various embodiments, the PVA has a molecular weight of less than about 80,000 Dalton (e.g., 1,000-50,000, 25,000-75,000 Dalton), between about 80,000 Dalton and 120,000 Dalton (e.g., 85,000-95,000, 100,000-110,000 Dalton), and/or more than about 120,000 Dalton (e.g., 150,000-300,000 Dalton). In one embodiment, the polymer is polyvinylpyrrolidone (PVP). In various embodiments, the PVP has a molecular weight of less than about 20,000 Dalton (e.g., 2,000-12,000 Dalton), more than about 20,000 Dalton (e.g., 35,000-400,000 Dalton), between about 20,000 Dalton and 60,000 Dalton (e.g., 40,000-55,000 Dalton), and/or more than about 60,000 Dalton (e.g., 70-100,000, 90-150,000 Dalton). In one embodiment, the polymer is an ethylene oxide derivative.
- In one embodiment, the polymer is a polyethylene glycol (PEG). In various embodiments, the PEG has a molecular weight of less than about 5,000 Dalton (e.g., 200-3,000, 1,000-4,500 Dalton), between about 5,000 Dalton and 10,000 Dalton (e.g., 7,000-8,000, 6,000-7,500 Dalton), and/or more than about 10,000 Dalton (e.g., 12,000-35,000, 18,000-45,000 Dalton). In one embodiment, the PEG contains a single functional group. In one embodiment, the PEG contains more than one functional group (e.g., two, three, or more functional groups). In one embodiment, the functional group or groups comprise any of an amine, thiol, acrylate, alkyne, maleimide, silane, azide, hydroxyl, lipid, disulfide, fluorescent molecule, and/or biotin. In one embodiment, the functional group or groups can be any one or more of an amine, thiol, acrylate, alkyne, maleimide, silane, azide, hydroxyl, lipid, disulfide, fluorescent molecule, and/or biotin. In one embodiment, the concentration stabilizing agent is a carbohydrate derivative. In various embodiments, the polymer is a monosaccharide, a disaccharide, an oligosaccharide, a polysaccharide, and/or dextran. In various embodiments, the dextran has a molecular weight that is less than about 2,000 Dalton (e.g., 200-1,400, 1,000-1,900 Dalton), between about 2,000 Dalton and 5,000 Dalton (e.g., 3,000-3,500, 2,000-4,000 Dalton), and/or more than about 5,000 Dalton (e.g., 6,000-8,000, 7,000-13,000 Dalton).
- In various embodiments, the concentration stabilizing chemical agent is any one or more of a phenol, a monomeric phenol, a dimeric phenol, a trimeric phenol, a polyphenol, a tannic acid, is gum Arabic, a biological molecule, a protein, a bovine serum albumin, streptavidin, biotin, a peptide, an oligonucleotide, a naturally occurring oligonucleotide, a synthetic oligonucleotide, a metal or metalloid oxide, and/or a silicon dioxide shell. In one embodiment, a silicon dioxide shell has ranges in thickness from about less than 1 nm to about 100 nm (e.g., 10-70, 30-90, 40-60 nm). In one embodiment, a combination of stabilizing agents are used. In various embodiments, the solvent can be one or more of water, an alcohol, ethanol, isopropyl alcohol, t-butanol, a mixture of a water and an alcohol.
- In one embodiment, the concentration of silver nanoplates is increased using tangential flow filtration. In one embodiment, the tangential flow filtration is performed using a tangential flow filter membrane. In one embodiment, the tangential flow membrane is made from a cellulose ester or mix of cellulose esters. In various embodiments, the tangential flow membrane is made from one or more of polyetheresulfone and/or polysulfone. In various embodiments, the tangential flow membrane has a molecular weight cut off of less than about 10 kD (e.g., 1-5, 8 kD), of between about 10 kD and 500 kD (e.g., 50-250, 300-400 kD), of more than about 500 kD (e.g., 750, 1000, 5000 kD or more), of less than about 0.05 μm, of between about 0.05 μm and 0.5 μm (e.g., 0.01, 0.03 μm), and/or of more than about 0.5 μm (e.g., 1.0, 2, 5, 10, 100 μm).
- In various embodiments, the silver nanoplate solution is concentrated to produce a solution with an optical density of greater than about 10 cm−1 (e.g., 15-45 cm−1, 30-150 cm−1, or more), greater than about 50 cm−1 (e.g., 80-150 cm−1, 60-120 cm−1, 100 cm−1 or more), greater than about 75 cm−1 (e.g., 80-110 cm−1, 200-400 cm−1, 1000 cm−1 or more), greater than about 100 cm−1 (e.g., 150-350 cm−1, 200-400 cm−1 or more), and/or greater than about 500 cm−1 (e.g., 600-1500 cm−1, 1000 cm−1 or more).
- In one embodiment, the solvent of the concentrated solution is exchanged using tangential flow filtration. In one embodiment, the concentrated solution is processed to remove residual chemicals using tangential flow filtration.
- In various embodiments, a solution of nanoparticles comprising silver nanoparticles is coated with a polymer with an optical density greater than 100 cm−1 (e.g., 160-550 cm−1, 900-1100 cm−1, 100 cm−1, 1000 cm−1 or more).
- In one embodiment, the solution of silver nanoplates is incubated with a substrate (e.g., fibers, cloth, mesh, bandages, socks, wraps, other articles of clothing, sponges, high porosity substrates, particles with edge lengths greater than 1 micron, beads, hair, skin, paper, absorbent polymers, foam, wood, cork, slides, roughened surfaces, biocompatible substrates, filters, and/or medical implants). In one embodiment, the substrate is removed from the solution of silver nanoplates and dried.
- Further objects, features and advantages of the invention will become apparent from the following detailed description taken in conjunction with the accompanying figures showing illustrative embodiments of the invention, in which the following is a description of the drawings. The drawings are examples, and should not be used to limit the embodiments. Moreover, recitation of embodiments having stated features is not intended to exclude other embodiments having additional features or other embodiments incorporating different combinations of the stated features. Further, features in one embodiment (such as in one figure) may be combined with descriptions (and figures) of other embodiments.
-
FIG. 1 illustrates the optical spectrum of a silver nanoplate solution as fabricated using a photoconversion method according to one embodiment of the present invention. In one embodiment, a silver nanoplate solution is fabricated using a photoconversion method identified as [DSS1099, alternative spectrum ARS1134]—as fabricated, these silver nanoplates have an optical density of less than 1 cm−1. -
FIG. 2 illustrates a transmission electron micrograph of silver nanoplates fabricated using a photoconversion method according to one embodiment of the present invention. Scale bar is 50 nm. -
FIG. 3 illustrates one embodiment of plates concentrated in the absence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration. After concentration the plates have a significantly changed peak shape as demonstrated by the normalized plot, and a spectral peak at 400 nm that demonstrates that a large number of silver nanoplates have turned into silver nanospheres. In one embodiment, plates are concentrated with the identification [MGM1201 and 1195E]. -
FIG. 4 illustrates one embodiment of plates concentrated in the presence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration using a concentration stabilizing agent. After being concentrated the plates retain their spectral peak shape with no increase in the spectral peak at 400 nm. In one embodiment, plates are concentrated with the identification [MGM1282 and 1279A]. -
FIG. 5 illustrates extinction spectra of high optical density nanoplate solutions processed using the methods described in various embodiments of the invention. - Several embodiments of the present invention comprise processes for making solutions of plasmonic nanoparticle including silver nanoplates that are suitable for performing treatment of a target body region (e.g., such as for tumor ablation, hair removal, acne treatment, wound healing, and antimicrobial applications). Optical Density (O.D.) is the logarithmic ratio of the radiation incident on a material to the radiation transmitted through the material (O.D.=−log10(I1/I0) where I1 is the intensity of transmitted light and I0 is the intensity of the incident light). For solutions, the optical density is a function of the path length through the liquid sample is expressed in units of cm−1. In some instances, optical density is expressed without the unit cm−1—such as in instances in which a standard path length of 1 cm is used.
- In one embodiment, silver nanoplates are characterized by lengths along the three principle axes wherein: the axial length of two of the principle axes is at least two times greater than the axial length of the shortest principle axis and the shortest principal axial length is less than about 500 nm.
- The ratio of the average of the two longer principle axes to the shorter principle axes is referred to as the aspect ratio. In one embodiment the average aspect ratio of the silver plates is greater than 1.5, 2, 3, 4, 5, 7, 10, 20, 30, or 50, or any range therein (e.g., greater than 8, 9, 11, 12, 13, 14, 15, 25, 35, 40, 45). In various embodiments the average aspect ratio of the silver plates is between 1.5 and 25, 2 and 25, 1.5 and 50, 2 and 50, 3 and 25, or 3 and 50 (e.g., 5 and 20, 10 and 15, 5 and 40, 5 and 30, 5 and 20, 10 and 50, 20 and 50, 30 and 50, 40 and 50, 10 and 20, 20 and 30, 30 and 40, 40 and 50, and any values between 1.5 and 50, inclusive).
- In one embodiment the nanoplate has edge lengths less than 500 nm, 250 nm, 200 nm, 150 nm, 100 nm, 80 nm, 60 nm or 50 nm (e.g., 400 nm, 300 nm, 225 nm, 175 nm, 125 nm, 90 nm, 70 nm, 55 nm, and any values between 500 and 50 nm, inclusive). In one embodiment the nanoplate has edge lengths greater than 5 nm, 10 nm, 20 nm, 30 nm, 50 nm or 100 nm, or any value therein or more (e.g., 15, 25, 40, 60, 70 75, 80, 90, 5-100, 20-80, 30-50, 45-95 nm, and/or 30 nm to 100 nm, 20 nm to 150 nm, 10 nm to 200 nm, 10 nm to 300 nm). In one embodiment the nanoplate has a thickness (third principle axis) that is less than 500 nm, 300 nm, 200 nm, 100 nm, 80 nm, 60 nm, 50 nm, 40 nm, 30 nm, 20 nm, or 10 nm, or any value therein (e.g., 400 nm, 250 nm, 150 nm, 75 nm, 5 nm to 20 nm, 5 nm to 30 nm, 10 nm to 30 nm, 10 nm to 50 nm, 10 nm to 100 nm).
- Silver nanoplates have a variety of different cross sectional shapes including circular, triangular, or shapes that have any number of discrete edges. In one embodiment the nanoplates have less than 20, 15, 10, 8, 6, 5, or 4 edges (e.g., 18, 12, 11, 9, 2, 1). In one embodiment the nanoplates have more than 2, 3, 4, or 5 edges (e.g., 6, 7, 10, 15, 20 or more). In some embodiments the silver nanoplates have sharp corners and in other embodiments the corners are rounded. In some embodiments of silver nanoplates, there are a variety of different cross sectional shapes within the same sample. In other embodiments of silver nanoplate solutions greater than 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the number of particles in solution are silver nanoplates with the other particles having different shapes including but not limited to spherical, cubic, and irregular. In one embodiment the nanoplates have one or two flat sides. In another embodiment the nanoplates are pyramidal.
- The silver nanoplates utilized in various embodiments of this invention may be fabricated using photoconversion (Jin et al. 2001; Jin et al. 2003), pH controlled photoconversion (Xue 2007), thermal growth (Hao et al. 2004; Hao 2002; He 2008; Metraux 2005), templated growth (Hao et al. 2004; Hao 2002), seed mediated growth (Aherne 2008; Chen; Carroll 2003; Chen; Carroll 2002, 2004; Chen et al. 2002; He 2008; Le Guevel 2009; Xiong et al. 2007), or alternative methods. Alternative methods include methods in which the silver nanoplates are formed from a solution comprising a shape stabilizing agent or agents and a silver source, and in which chemical agents, biological agents, electromagnetic radiation, or heat are used to reduce the silver source.
-
FIG. 1 illustrates the optical spectrum of a silver nanoplate solution as fabricated using a photoconversion method according to one embodiment of the present invention. In one embodiment, a silver nanoplate solution is fabricated using a photoconversion method identified as [DSS1099, alternative spectrum ARS1134]—as fabricated, these silver nanoplates have an optical density of less than 1 cm−1. -
FIG. 2 illustrates a transmission electron micrograph of silver nanoplates fabricated using a photoconversion method according to one embodiment of the present invention. InFIG. 2 , the scale bar is 50 nm. -
FIG. 3 illustrates one embodiment of plates concentrated in the absence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) optical extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration. After concentration the plates have a significantly changed peak shape as demonstrated by the normalized plot, and a spectral peak at 400 nm that demonstrates that a large number of silver nanoplates have turned into silver nanospheres. In one embodiment, plates are concentrated with the identification [MGM1201 and 1195E]. -
FIG. 4 illustrates one embodiment of plates concentrated in the presence of a concentration stabilizing agent with normalized (bottom) and unnormalized (top) optical extinction spectra of as-fabricated silver nanoplates before and after tangential flow filtration concentration using a concentration stabilizing agent. After being concentrated the plates retain their spectral peak shape with no increase in the spectral peak at 400 nm. In one embodiment, plates are concentrated with the identification [MGM1282 and 1279A]. -
FIG. 5 illustrates optical extinction spectra of high optical density nanoplate solutions processed using the methods described in various embodiments of the invention. - In one embodiment, silver nanoplates have molecules that are adsorbed or otherwise bound to the particle surface. The molecules on the surface are the reactants or reactant by-products of the synthesis. One object of one embodiment of this invention is to partially or fully exchange the molecules that are bound to the surface of the silver nanoplates with other molecules that more fully protect the particles from changing shape during concentration. Another object of one embodiment of the invention is to use a stabilizing agent during fabrication that generates plate shapes and also stabilizes the nanoplates during subsequent concentration.
- In various embodiments, stabilizing agent variants that may be utilized include chemical or biological agents that are physisorbed to the surface, molecularly bound to the surface through specific interactions (e.g. thiol or amine), or encapsulate the surface (i.e. a metal oxide or metalloid oxide shell). In various embodiments, specific chemical agents of interest include polymers such as polysulphonates, vinyl polymers, carbohydrates, ethylene oxides, phenols, and carbohydrates. In various embodiments, specific examples of these polymers include poly(sodium) styrene sulfonate, polyvinyl alcohol, polyvinyl pyrrolidone, tannic acid, dextran, and polyethylene glycol (PEG) including PEG molecules which contain one or more chemical groups (e.g. amine, thiol, acrylate, alkyne, maleimide, silane, azide, hydroxyl, lipid, disulfide, fluorescent molecule, or biomolecule moieties). In various embodiments, specific biomolecules of interest include proteins, peptides, and oligonucleotides, including biotin, bovine serum albumin, streptavidin, neutravidin, wheat germ agglutinin, naturally occurring and synthetic oligonucleotides and peptides, including synthetic oligonucleotides which have one or more chemical functionalities (e.g. amine, thiol, dithiol, acrylic phosphoramidite, azide, digoxigenin, alkynes, or biomolecule moieties). Specific encapsulating chemical agents of interest include metal oxide shells such as SiO2 and TiO2. Stabilizing agents may be added prior to the formation of silver nanoplates, during the formation of silver nanoplates, or after the formation of silver nanoplates. An additional chemical agent of interest is gum arabic.
- In one embodiment of this invention the silver nanoplates are fabricated in aqueous solutions. In other embodiments the silver nanoplates are fabricated in other solutions that can include ethanol, isopropanol, or organic solvents such as heptane, toluene, or butanol.
- In one embodiment an acid, base or buffering agent (e.g., a buffer) is added to change the solution pH either before, during, or after the addition of a stabilant. In various embodiments, the nanoplates are suspended in a sodium bicarbonate buffer or a sodium borate buffer.
- In various embodiments, stabilizing agents can be solid or liquid formulations that are added to the silver plate solution. The stabilizing agents have an affinity for the surface of the silver nanoplates and will associate with the plate surface. In some embodiments, the bound molecules on the silver nanoplates will be displaced by the added stabilizing agents. In some embodiments the stabilants are added to the as-fabricated silver nanoplate solution. In other embodiments, the solution of nanoplates is washed, or the residual reactants are otherwise removed. In other embodiments, the suspending solution is exchanged with a different suspending media which includes ethanol, isopropanol, or other polar or non-polar liquids before the stabilizing agents are added.
- Once the stabilizing agent is added, the mixture of the stabilant and the silver nanoplates can undergo a number of different processes including heating, boiling, boiling under reflux, rotoevaporation, vacuum, stirring, stirring with magnetic stir bars, stirring with overhead mixers, stirring with homogenizers, shaking, microfluidization, refrigeration, and freezing.
- In one embodiment, after the stabilization step is complete, the silver nanoplates can be washed to remove residual reactants or to exchange the solution with another solution. In various embodiments, the exchange of solution can be accomplished using dialysis, centrifugation, filtration, or tangential flow filtration. One embodiment of the invention is where the number of wash volumes exchanged within the sample is 1, 2, 3, 4, 5, between 1 and 5, between 5 to 10, between 10 to 20, or more than 20 wash volumes.
- High optical density solutions of the nanoparticles can be fabricated using centrifugation, evaporation, filtration, dialysis or tangential flow filtration. One embodiment of this invention utilizes tangential flow filtration as the process of concentrating the silver nanoplate solution. The filter membrane utilized may be formed from a variety of materials. Specific filter membrane materials of interest include cellulose esters, polysulfone, and polyetheresulfone. The filter membrane utilized may have pores with a molecular weight cutoff of less than about 10 kD, between 10 kD to 500 kD, or more than about 500 kD (e.g., between 10 kD, to 100 kD, 10 kD to 500 kD, 20 kD to 500 kD, 20 kD to 250 kD), and/or pore sizes of less than about 0.05 μm, between 0.05 μm and 0.5 μm, or larger than about 0.5 μm (e.g., between 0.02 μm and 0.1 μm, 0.05 μm and 0.2 μm, 0.05 μm and 0.5 μm, 0.10 μm and 0.2 μm, 0.1 μm and 0.5 μm). Tangential flow filtration can also be utilized to change the solvent in which the silver nanoplates are dispersed. Specific solvents of interest include water and alcohols (e.g. t-butanol, ethanol, and isopropyl alcohol), as well as other polar or non-polar solvents. Additionally, tangential flow filtration can be utilized to remove residual chemicals.
- This invention includes embodiments in which the silver nanoplate solution concentration is increased to produce a final solution with optical densities of greater than about 5 cm−1, greater than about 10 cm−1, greater than about 50 cm−1, greater than about 75 cm−1, greater than about 100 cm−1, greater than about 500 cm−1, or greater than about 1000 cm−1 (e.g., between 10 cm−1 to 100 cm−1, 30 cm−1 to 300 cm−1, 50 cm−1 to 500 cm−1, 100 cm−1 to 1000 cm−1, 300 cm−1 to 3000 cm−1, or 500 cm−1 to 5000 cm−1) One embodiment of the invention is where the silver nanoplate solution concentration is increased to above 106, 107, 108, 109, 1010, 1011, 1012, 1013 particles per milliliter.
- One embodiment of the invention is where the concentrated particles are stored at temperatures below −10, 0, 4, 6, 10, or 20 degrees C.
- One embodiment of the invention is where the particles are frozen and dried under vacuum. One embodiment is where the particles are freeze dried. One embodiment is where the particles are supercritically dried. Another embodiment is where an additional stabilant or other cryoprotectant is added to the solution before the particles are heat dried or freeze dried.
- In one embodiment of the invention, high optical density solutions of silver nanoplates are associated with a substrate. Examples of substrates include fibers, cloth, mesh, bandages, socks, wraps, other articles of clothing, sponges, high porosity substrates, particles with diameters greater than 1 micron, beads, hair, skin, paper, absorbent polymers, foam, wood, cork, slides, roughened surfaces, biocompatible substrates, filters, or medical implants. In one embodiment, the high optical density solutions of silver nanoplates at a concentration of at least 1 mg/mL, 10 mg/mL, 100 mg/mL (e.g., 1 to 10, 3 to 30, 5 to 50, 10 to 20, 5 to 50, 3 to 50, 1 to 100 mg/mL, 10 to 100, 20 to 100, 30 to 100 mg/mL) are incubated with the substrate. In another embodiment, the high optical density solutions of silver nanoplates at a concentration of at least 1 mg/mL, 10 mg/mL, or 100 mg/mL (e.g., 1 to 10, 3 to 30, 5 to 50, 10 to 20, 5 to 50, 3 to 50, 1 to 100 mg/mL, 10 to 100, 20 to 100, 30 to 100 mg/mL) are incubated with the substrate. In another embodiment the silver nanoplates are prepared at an optical density of at least 10, 100, 300, 500, 1000, or 2000 cm−1 (e.g., between 10-100, 20-200, 30-300, 50-500, 100-1000, 200-1000, 300-1000, 500-1000, or 200-2000 cm−1) before incubating with the substrate. In another embodiment the substrate is chemically treated to increase the binding of the nanoplates to the substrate. For example, the substrate could be functionalized with a molecule that yielded a positively or negatively charged surface. In another embodiment, the pH of the incubating solution is selected in order to optimize binding. In another embodiment, the silver nanoplates cover at least 5%, 10%, 20%, 30%, 50% or 75% of the substrate (e.g., 5% to 10%, 10% to 100%, 10% to 50%, 50% to 100%, 30% to 100%, 30% to 70%, 40% to 80%, 50% to 90%, 60% to 100%, 70% to 100%, 80% to 100%, 90% to 100%, 0% to 5%, 1% to 10%, 2% to 20%, 5% to 30%, and/or 1% to 50% of the substrate). In another embodiment, other solvents or chemicals are added to the incubation solution. In another embodiment a biological linker (e.g. antibodies, peptides, DNA) is used to bind the high optical density silver nanoplates to the surface of the substrate. In one embodiment, the incubation is for less than 1 minute, 5 minutes, 20 minutes, 60 minutes, or 120 minutes (e.g., 0 to 1 minute, 1 minute to 120 minutes, 5 minutes to 120 minutes, 20 minutes to 120 minutes, 60 minutes to 120 minutes, 5 minutes to 60 minutes, 10 minutes to 60 minutes, 20 minutes to 60 minutes, 0 minutes to 10 minutes, 0 minutes to 20 minutes, or 0 minutes to 5 minutes).
- In one embodiment, the substrate is separated from the incubating solution and dried. The substrate can be dried using air drying, heat drying, freeze drying, or supercritical drying. In another embodiment the dried substrate can be further processed by soaking the substrate in another material, painting the substrate with another material, or exposing the substrate to another material that is in the vapor phase.
- Other embodiments of the invention will be apparent to those skilled in the art from consideration of the specification and practice of the invention disclosed herein. It is intended that the specification and examples be considered as disclosing certain embodiments of the invention only, with a true scope and spirit of the invention being indicated by the following claims.
- The subject matter described herein may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The foregoing embodiments are therefore to be considered in all respects illustrative rather than limiting. While embodiments are susceptible to various modifications, and alternative forms, specific examples thereof have been shown in the drawings and are herein described in detail. It should be understood, however, that the invention is not to be limited to the particular forms or methods disclosed, but to the contrary, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the various embodiments described and the appended claims. Any methods disclosed herein need not be performed in the order recited.
- The methods disclosed herein include certain actions taken by a practitioner; however, they can also include any third-party instruction of those actions, either expressly or by implication. For example, actions such as “identifying a target region of skin tissue” include “instructing the identification of a target region of skin tissue.”
- The ranges disclosed herein also encompass any and all overlap, sub-ranges, and combinations thereof. Language such as “up to,” “at least,” “greater than,” “less than,” “between,” and the like includes the number recited. Numbers preceded by a term such as “about” or “approximately” or “substantially” include the recited numbers. For example, “about 3 mm” includes “3 mm.” The terms “approximately”, “about” and/or “substantially” as used herein represent an amount or characteristic close to the stated amount or characteristic that still performs a desired function or achieves a desired result. For example, the terms “approximately”, “about”, and “substantially” may refer to an amount that is within less than 10% of, within less than 5% of, within less than 1% of, within less than 0.1% of, and within less than 0.01% of the stated amount or characteristic.
- Modern nanoparticle synthesis techniques have enabled the development of materials with unique optical properties for a wide range of applications including diagnostic, obscurant, and therapeutic applications. When as-fabricated nanoplates are concentrated using tangential flow filtration, the shape many of the plates shift to nanospheres, reducing the formulation efficacy, as evidenced by the increased peak height at 400 nm. By exchanging the surface capping agent of as-fabricated silver nanoplates with an agent that provides stability before, during, and/or after concentration, the silver nanoplates can be concentrated to increase the solution optical density without destabilizing the plates and degrading the beneficial optical properties.
- The description of specific examples below are intended for purposes of illustration only and are not intended to limit the scope of the invention disclosed herein.
- 15 L of silver nanoplates with a peak optical density of about 5 cm−1 were mixed with 3.5 g of polyvinylalcohol (PVA), and concentrated using tangential flow filtration using a 500 kD polysulfone tangential flow membrane with 3100 cm2 of surface area. The solution was concentrated for approximately 90 minutes, and the final solution volume was reduced from 15 L to 0.5 L. The increase of the silver nanoplate solution optical density was from 5 to about 150 cm−1. Thus, according to one embodiment, a method for increasing a silver nanoplate solution from 5 cm−1 to 150 cm−1 (e.g., an increase of roughly 30 times the optical density) comprises the steps of adding PVA to silver nanoplates, and concentrating the solution with tangential flow filtration.
- 1.2 L of silver nanoplates with a peak optical density of about 4 cm−1 were mixed with 4 L of anhydrous ethanol and about 49 mL of ammonium hydroxide solution. 0.6 mL of a dilute aminopropyltriethoxysilane (APTES) was added to the solution. After 15 minutes of incubation, 6.5 mL of tetraethylorthosilicate (TEOS) solution was added. After 24 hours 1 L of the solution was concentrated using a 500 kD polysulfone tangential flow membrane with 1050 cm2 of surface area. The final solution volume was decreased to 150 mL, increasing the silver nanoparticle solution optical density to about 40 cm−1. Thus, according to one embodiment, a method for increasing a silver nanoplate solution from 4 cm−1 to 40 cm−1 (e.g., an increase of roughly 10 times the optical density) comprises the steps of adding anhydrous ethanol, ammonium hydroxide solution, aminopropyltriethoxysilane (APTES), and tetraethylorthosilicate (TEOS) to the silver nanoplates, and concentrating the solution with tangential flow filtration.
- A 40 mL solution of 40 O.D. solution of concentrated silver nanoplates was spun at 3000 RCF for 30 minutes. This processed was used to concentrate the silver nanoplates to an optical density of 1000 O.D.
- A 5 mL solution of 1000 OD silver nanoplates was added to a 3″×3″ section of absorbant cloth (Absorber Synthetic Drying Chamois, Clean Tools). After addition, the substrate was allowed to air dry. Once dried, the silver nanoplates were bound to the surface of the absorbant cloth and were not released when the cloth was subsequently wet and water removed by applying pressure.
-
- Aherne, D. L., D. M.; Gara, M.; Kelly, J. M., 2008: Optical Properties and Growth Aspects of Silver Nanoprisms Produced by Highly Reproducible and Rapid Synthesis at Room Temperature. Advanced Materials, 18, 2005-2016.
- Chen, S., and D. L. Carroll, 2003: Controlling 2-dimensional growth of silver nanoplates. Self-Assembled Nanostructured Materials Symposium (Mater. Res. Soc. Symposium Proceedings Vol. 775), 343-348|xiii+394.
- Chen, S. H., and D. L. Carroll, 2002: Synthesis and characterization of truncated triangular silver nanoplates. Nano Letters, 2, 1003-1007.
- Chen, S. H., and D. L. Carroll, 2004: Silver nanoplates: Size control in two dimensions and formation mechanisms. Journal of Physical Chemistry B, 108, 5500-5506.
- Chen, S. H., Z. Y. Fan, and D. L. Carroll, 2002: Silver nanodisks: Synthesis, characterization, and self-assembly. Journal of Physical Chemistry B, 106, 10777-10781.
- Hao, E., G. C. Schatz, and J. T. Hupp, 2004: Synthesis and optical properties of anisotropic metal nanoparticles. Journal of Fluorescence, 14, 331-341.
- Hao, E. K., K. L.; Hupp, J. T.; Schatz, G. C., 2002: Synthesis of Silver Nanodisks using Polystyrene Mesospheres as Templates. J Am Chem Soc, 124, 15182-15183.
- He, X. Z., X.; Chen, Y.; Feng, J., 2008: The evidence for synthesis of truncated silver nanoplates in the presence of CTAB. Materials Characterization, 59, 380-384.
- Jin, R., Y. Cao, C. A. Mirkin, K. L. Kelly, G. C. Schatz, and J. G. Zheng, 2001: Photoinduced Conversion of Silver Nanospheres to Nanoprisms. Science, 294, 1901-1903.
- Jin, R., Y. C. Cao, E. Hao, G. S. Metraux, G. C. Schatz, and C. A. Mirkin, 2003: Controlling anisotropic nanoparticle growth through plasmon excitation. Nature, 425, 487.
- Le Guevel, X. W., F. Y.; Stranik, O.; Nooney, R.; Gubala, V.; McDonagh, C.; MacCraith, B. D., 2009: Synthesis, Stabilization, and Functionalization of Silver Nanoplates for Biosensor Applications. J Phys Chem C, 113, 16380-16386.
- Metraux, G. S. M., C. A; 2005: Rapid Thermal Synthesis of Silver Nanoprisms with Chemically Tailorable Thickness. Advanced Materials, 17, 412-415.
- Xiong, Y. J., A. R. Siekkinen, J. G. Wang, Y. D. Yin, M. J. Kim, and Y. N. Xia, 2007: Synthesis of silver nanoplates at high yields by slowing down the polyol reduction of silver nitrate with polyacrylamide. Journal of Materials Chemistry, 17, 2600-2602.
- Xue, C. M., C. A., 2007: pH-Switchable Silver Nanoprism Growth Pathways. Angew Chem Int Ed, 46, 2036-2038.
- Each of the references listed above is incorporated by reference in its entirety.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/974,987 US20160101130A1 (en) | 2012-10-11 | 2015-12-18 | Silver nanoplate compositions and methods |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261795149P | 2012-10-11 | 2012-10-11 | |
US14/048,996 US9249334B2 (en) | 2012-10-11 | 2013-10-08 | Silver nanoplate compositions and methods |
US14/974,987 US20160101130A1 (en) | 2012-10-11 | 2015-12-18 | Silver nanoplate compositions and methods |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/048,996 Continuation US9249334B2 (en) | 2012-10-11 | 2013-10-08 | Silver nanoplate compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
US20160101130A1 true US20160101130A1 (en) | 2016-04-14 |
Family
ID=50475524
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/048,996 Active - Reinstated US9249334B2 (en) | 2012-10-11 | 2013-10-08 | Silver nanoplate compositions and methods |
US14/681,379 Expired - Fee Related US9212294B2 (en) | 2012-10-11 | 2015-04-08 | Silver nanoplate compositions and methods |
US14/947,508 Active US9526745B2 (en) | 2012-10-11 | 2015-11-20 | Silver nanoplate compositions and methods |
US14/974,987 Abandoned US20160101130A1 (en) | 2012-10-11 | 2015-12-18 | Silver nanoplate compositions and methods |
US15/374,942 Active 2034-07-06 US10688126B2 (en) | 2012-10-11 | 2016-12-09 | Silver nanoplate compositions and methods |
US16/902,455 Active 2034-05-20 US11583553B2 (en) | 2012-10-11 | 2020-06-16 | Silver nanoplate compositions and methods |
US18/089,047 Pending US20230139868A1 (en) | 2012-10-11 | 2022-12-27 | Silver nanoplate compositions and methods |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/048,996 Active - Reinstated US9249334B2 (en) | 2012-10-11 | 2013-10-08 | Silver nanoplate compositions and methods |
US14/681,379 Expired - Fee Related US9212294B2 (en) | 2012-10-11 | 2015-04-08 | Silver nanoplate compositions and methods |
US14/947,508 Active US9526745B2 (en) | 2012-10-11 | 2015-11-20 | Silver nanoplate compositions and methods |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/374,942 Active 2034-07-06 US10688126B2 (en) | 2012-10-11 | 2016-12-09 | Silver nanoplate compositions and methods |
US16/902,455 Active 2034-05-20 US11583553B2 (en) | 2012-10-11 | 2020-06-16 | Silver nanoplate compositions and methods |
US18/089,047 Pending US20230139868A1 (en) | 2012-10-11 | 2022-12-27 | Silver nanoplate compositions and methods |
Country Status (16)
Country | Link |
---|---|
US (7) | US9249334B2 (en) |
EP (2) | EP3272388A1 (en) |
JP (3) | JP6325552B2 (en) |
KR (2) | KR102154207B1 (en) |
CN (2) | CN104822412B (en) |
AU (5) | AU2013329450B2 (en) |
BR (1) | BR112015008063A2 (en) |
CA (1) | CA2887687A1 (en) |
DK (1) | DK2906286T3 (en) |
ES (1) | ES2629903T3 (en) |
HK (2) | HK1212931A1 (en) |
IL (4) | IL305614A (en) |
MX (1) | MX2015004524A (en) |
PL (1) | PL2906286T3 (en) |
RU (1) | RU2646809C2 (en) |
WO (1) | WO2014058904A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220072535A1 (en) * | 2019-04-30 | 2022-03-10 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
ES2670719T3 (en) | 2010-08-27 | 2018-05-31 | Sienna Biopharmaceuticals, Inc. | Compositions and methods for directed thermomodulation |
PT3489685T (en) | 2011-11-21 | 2024-01-04 | Zoetis Services Llc | Signal amplification in lateral flow and related immunoassays |
US10058500B2 (en) * | 2011-11-30 | 2018-08-28 | Fundació Institut De Ciències Fotòniques | Method for enhanced photoepilation based on metallic nano-complexes |
US9249334B2 (en) | 2012-10-11 | 2016-02-02 | Nanocomposix, Inc. | Silver nanoplate compositions and methods |
WO2014066850A2 (en) * | 2012-10-26 | 2014-05-01 | Nanocomposix, Inc. | Metastable silver nanoparticle composites |
TWI691716B (en) | 2014-08-13 | 2020-04-21 | 美商艾巴希斯公司 | Signal amplification in plasmonic specific-binding partner assays |
US11111396B2 (en) * | 2014-10-17 | 2021-09-07 | C3 Nano, Inc. | Transparent films with control of light hue using nanoscale colorants |
AU2016301375B2 (en) | 2015-08-04 | 2022-03-03 | Zoetis Services Llc | Signal amplification in solution-based plasmonic specific-binding partner assays |
WO2017049125A1 (en) | 2015-09-16 | 2017-03-23 | La Jolla Nanomedical | A cellular activity targeted nanoparticle system and methods of producing the nanoparticle system |
US10147512B2 (en) | 2015-12-09 | 2018-12-04 | C3Nano Inc. | Methods for synthesizing silver nanoplates and noble metal coated silver nanoplates and their use in transparent films for control of light hue |
CN106601914B (en) * | 2016-12-22 | 2018-11-09 | 东南大学 | A kind of preparation method of polycrystalline super thin metal film and two-dimensional nano figure |
CN107184981A (en) * | 2017-06-08 | 2017-09-22 | 浙江大学 | A kind of sheet Triangular Silver nanoparticle antibacterial suspension and its preparation method and application |
CN107414069B (en) * | 2017-08-07 | 2019-03-12 | 国家纳米科学中心 | Silver nanoparticle disk, preparation method and Gin Nanometer globoid and assembly using its preparation |
WO2019051826A1 (en) * | 2017-09-18 | 2019-03-21 | 深圳大学 | Surface-enhanced raman scattering substrate for detecting aromatic coenzyme nad+/nadh and preparation method therefor and use thereof |
CN107716944B (en) * | 2017-10-31 | 2019-10-08 | 长春黄金研究院有限公司 | The method that chemical method prepares nano-grade silver powder |
CN108188386B (en) * | 2017-12-25 | 2019-10-15 | 西安交通大学 | A kind of ultra-thin Ag nanometer sheet of clean surface and preparation method thereof |
CN108594341B (en) * | 2018-06-13 | 2020-08-04 | 中国工程物理研究院应用电子学研究所 | Preparation of gold nanosheet-gold nanosphere dimer and application of gold nanosheet-gold nanosphere dimer in strong polarization-dependent Fano resonance |
US10967197B2 (en) | 2018-08-29 | 2021-04-06 | Azulite, Inc. | Phototherapy devices and methods for treating truncal acne and scars |
CN109434129B (en) * | 2018-11-01 | 2021-06-25 | 首都师范大学 | Preparation of Au @ SiO2Method for preparing composite nano-particles with @ Ag three-layer core-shell structure |
CN109500405B (en) * | 2019-01-17 | 2022-02-22 | 鲁东大学 | Preparation method of triangular silver nanosheet |
CN113811409A (en) * | 2019-05-06 | 2021-12-17 | 巴斯夫欧洲公司 | Compositions comprising silver nanoplates |
JP7212370B2 (en) * | 2019-05-28 | 2023-01-25 | Cdmインフラ環境株式会社 | Method for producing nanoparticles with plasmon absorption in the near-infrared region |
CN110143609B (en) * | 2019-05-30 | 2021-12-14 | 上海理工大学 | Preparation method for synthesizing nano zinc oxide with controllable shape based on direct precipitation method |
WO2022031537A1 (en) * | 2020-08-03 | 2022-02-10 | Reed Frank Joseph | Compositions for prevention and treatment of rsv and coronavirus infection |
CN112299936B (en) * | 2020-11-06 | 2021-09-17 | 西南科技大学 | Preparation method and application of photo-thermal material for explosive laser detonation |
CA3218468A1 (en) | 2021-05-12 | 2022-11-17 | Basf Se | Compositions, comprising platelet-shaped transition metal particles |
CN113714500B (en) * | 2021-09-18 | 2023-07-11 | 浙江希维纳米科技有限公司 | Purification method of superfine silver nanowire |
CN114042929A (en) * | 2021-10-26 | 2022-02-15 | 西安交通大学 | High-concentration silver nano-micron sheet and synthesis method thereof |
CN114160785B (en) * | 2021-11-17 | 2024-01-26 | 武汉船用电力推进装置研究所(中国船舶重工集团公司第七一二研究所) | Preparation method of mild condition controllable nano silver solution |
CN115364118B (en) * | 2022-09-23 | 2023-08-25 | 上海交通大学医学院附属第九人民医院 | Silver-containing microcarriers and their use in wound healing |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2885366A (en) * | 1956-06-28 | 1959-05-05 | Du Pont | Product comprising a skin of dense, hydrated amorphous silica bound upon a core of another solid material and process of making same |
US20070158611A1 (en) * | 2005-11-08 | 2007-07-12 | Oldenburg Steven J | Compositions comprising nanorods and methods of making and using them |
US20120059307A1 (en) * | 2010-08-27 | 2012-03-08 | Sienna Labs, Inc. | Compositions and Methods for Targeted Thermomodulation |
Family Cites Families (380)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1317245A (en) | 1919-09-30 | Threading attachment | ||
US1325730A (en) | 1919-12-23 | Buffer for automobiles | ||
US1167462A (en) | 1912-09-16 | 1916-01-11 | Wilson Remover Company | Finish-remover and process of making same. |
US1185242A (en) | 1912-12-09 | 1916-05-30 | Akron Cultivator Company | Fertilizer-distributing attachment for cultivators. |
US1112325A (en) | 1913-07-09 | 1914-09-29 | Richard W Roberts | Shipping-box for umbrellas and canes. |
US1208005A (en) | 1914-09-11 | 1916-12-12 | Thomas L Reed | Mail-box. |
US1267801A (en) | 1915-10-15 | 1918-05-28 | Pfanstiehl Company Inc | Process for welding tungsten ingots. |
US1210600A (en) | 1915-10-22 | 1917-01-02 | Cap Hold Inc | Cap-retainer for deformable tubes. |
US1201219A (en) | 1915-10-25 | 1916-10-10 | Spray Engineering Co | Mechanism for applying coating to shrapnel-shells and other articles. |
US1263447A (en) | 1916-10-07 | 1918-04-23 | Frank L Mcconnel | Saw-setting tool. |
US1267747A (en) | 1917-04-26 | 1918-05-28 | John C Forster | Tile-arch construction. |
US1506763A (en) | 1918-12-31 | 1924-09-02 | Westinghouse Electric & Mfg Co | Field-coil collar |
US1559393A (en) | 1920-02-19 | 1925-10-27 | Naugatuck Chem Co | Process for treating rubber and similar materials and to the products obtained thereby |
US1502574A (en) | 1921-01-03 | 1924-07-22 | Kylin Oskar | Adjustable reamer |
US1506765A (en) | 1921-05-17 | 1924-09-02 | Western Electric Co | System for controlling the speed of dynamo-electric machinery |
US1506764A (en) | 1921-07-09 | 1924-09-02 | Western Electric Co | Apparatus for and method of recording the temperature and humidity of the atmosphere |
US1506766A (en) | 1922-12-11 | 1924-09-02 | Frederick S Mccullough | Diffusion pump |
US1559394A (en) | 1923-05-04 | 1925-10-27 | Josiah H Williams | Mold for making glass sign plates |
US1529513A (en) | 1924-04-08 | 1925-03-10 | Swan Fred | Fishing tool for wells |
US1677843A (en) | 1925-02-04 | 1928-07-17 | Parkin Albert Samuel | Door hinge and support |
US1744789A (en) | 1926-09-15 | 1930-01-28 | Max C Miller | Knitting machine |
US1768749A (en) | 1928-01-09 | 1930-07-01 | Vito Louis De | Machine for making flat noodles |
US1861465A (en) | 1931-02-28 | 1932-06-07 | Westinghouse Electric & Mfg Co | Conveyer slot seal |
US1959914A (en) | 1932-08-03 | 1934-05-22 | George Wellington Abbey | Mold-cap filler bar for intertype casting machines |
US2231283A (en) | 1937-07-29 | 1941-02-11 | Jacques Wolf & Company | Manufacture of irish moss |
US2343047A (en) | 1942-07-29 | 1944-02-29 | Int Paper Co | Web severing and transfer device |
US2396010A (en) | 1944-05-12 | 1946-03-05 | Nathaniel Shapiro | Novelty carton |
US2416752A (en) | 1945-07-20 | 1947-03-04 | John M Hendrick | Wheeled suitcase |
US3905167A (en) | 1973-11-09 | 1975-09-16 | Berne A Watkins | Modularized building system |
GB2052805B (en) | 1979-06-29 | 1983-03-09 | Smiths Industries Ltd | Gas-turbine engine control |
JPS58217599A (en) | 1982-06-10 | 1983-12-17 | 花王株式会社 | Bleaching detergent composition |
FR2627388B1 (en) | 1988-02-18 | 1991-06-14 | Roussel Uclaf | NEW COSMETIC COMPOSITIONS FOR COMBATING CELLULITE |
FR2649888B1 (en) | 1989-07-18 | 1994-08-26 | Exsymol Sa | PRODUCTS FOR SKIN APPLICATIONS, WITH COSMETIC OR / AND THERAPEUTIC EFFECTS |
WO1991006894A1 (en) | 1989-10-18 | 1991-05-16 | Research Corporation Technologies, Inc. | Plasmon enhanced photo processes |
US5409797A (en) | 1991-03-04 | 1995-04-25 | Fuji Photo Film Co., Ltd. | Heat-sensitive recording material for laser recording |
FR2677246B1 (en) | 1991-06-04 | 1995-02-24 | Oreal | USE OF NANOPIGMENTS OF METAL OXIDES TO PROTECT KERATIN OF HAIR AGAINST ATMOSPHERIC AGGRESSIONS, AND GEL COMPOSITION USING THE SAME. |
FR2677543B1 (en) | 1991-06-13 | 1993-09-24 | Oreal | COSMETIC FILTERING COMPOSITION BASED ON BENZENE 1,4-DI ACID (3-METHYLIDENE-10-CAMPHOSULFONIC) AND NANOPIGMENTS OF METAL OXIDES. |
FR2677544B1 (en) | 1991-06-14 | 1993-09-24 | Oreal | COSMETIC COMPOSITION CONTAINING A MIXTURE OF NANOPIGMENTS OF METAL OXIDES AND MELANIC PIGMENTS. |
US5385729A (en) | 1991-08-01 | 1995-01-31 | Colgate Palmolive Company | Viscoelastic personal care composition |
FR2680684B1 (en) | 1991-08-29 | 1993-11-12 | Oreal | COSMETIC FILTERING COMPOSITION COMPRISING A METAL OXIDE NANOPIGMENT AND A FILTERED POLYMER. |
US5713845A (en) | 1991-10-29 | 1998-02-03 | Thermolase Corporation | Laser assisted drug delivery |
US5425728A (en) | 1991-10-29 | 1995-06-20 | Tankovich; Nicolai I. | Hair removal device and method |
US5226907A (en) | 1991-10-29 | 1993-07-13 | Tankovich Nikolai I | Hair removal device and method |
US5423803A (en) | 1991-10-29 | 1995-06-13 | Thermotrex Corporation | Skin surface peeling process using laser |
US5752948A (en) | 1991-10-29 | 1998-05-19 | Thermolase Corporation | Hair removal method |
US5817089A (en) | 1991-10-29 | 1998-10-06 | Thermolase Corporation | Skin treatment process using laser |
US5752949A (en) | 1991-10-29 | 1998-05-19 | Thermolase Corporation | Hair removal method |
US6132392A (en) | 1991-11-27 | 2000-10-17 | Stone; Ross G. | Tension headache reliever with multiple pain relieving modalities |
US5562643A (en) | 1992-12-28 | 1996-10-08 | Johnson; James B. | Device and treatment for treatment of skin |
FR2700952B1 (en) | 1993-01-29 | 1995-03-17 | Oreal | New cosmetic or dermopharmaceutical compositions in the form of aqueous gels modified by the addition of expanded microspheres. |
EG20471A (en) | 1993-07-12 | 1999-05-31 | Thermotrex Corp | Hair removal device and method |
FR2712188B1 (en) | 1993-11-08 | 1996-01-26 | Oreal | Cosmetic composition intended for making up the skin, its preparation process and make-up product obtained from said composition. |
US5647866A (en) | 1993-11-09 | 1997-07-15 | Zaias; Nardo | Method of hair depilation |
DE4344141C1 (en) | 1993-12-20 | 1995-07-13 | Coiffeur Consulting Team Elect | Cosmetic product for specific hair care |
FR2715843B1 (en) | 1994-02-09 | 1996-04-12 | Oreal | Sunscreen cosmetic compositions, preparation process and use. |
US5423337A (en) | 1994-03-24 | 1995-06-13 | Ahlert; Gary | Medicated dental floss |
CA2131750C (en) | 1994-07-26 | 2000-11-21 | Nikolai I. Tankovich | Improved hair removal method |
FR2727312B1 (en) | 1994-11-24 | 1997-05-23 | Oreal | COSMETIC COMPOSITION IN THE FORM OF COMPACT POWDER AND PREPARATION METHOD |
EP0805678B1 (en) | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
FR2731153B1 (en) | 1995-03-03 | 1997-04-11 | Oreal | COSMETIC COMPOSITION IN THE FORM OF A SOLID DISPERSION COMPRISING A FATTY PHASE, A POLYHYDRIC ALCOHOL AND FILLERS |
US20020009488A1 (en) | 1995-05-03 | 2002-01-24 | Polymasc Pharmaceuticals Plc | Tissue entrapment |
ATE164758T1 (en) | 1995-07-13 | 1998-04-15 | Oreal | USE OF HOLLOW DEFORMABLE PARTICLES AGAINST PHOTOBLUEING AND/OR BLEACHING A COSMETIC AND/OR DERMATOLOGICAL AGENT CONTAINING TITANIUM DIOXIDE PIGMENTS |
US6143287A (en) | 1996-02-27 | 2000-11-07 | New York Blood Center, Inc. | Method and composition for hair removal |
FR2746302B1 (en) | 1996-03-20 | 1998-12-24 | Oreal | COSMETIC COMPOSITIONS COMPRISING NANOPIGMENTS |
US5655547A (en) | 1996-05-15 | 1997-08-12 | Esc Medical Systems Ltd. | Method for laser surgery |
US5759767A (en) | 1996-10-11 | 1998-06-02 | Joseph R. Lakowicz | Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids |
US5830177A (en) | 1996-11-22 | 1998-11-03 | Anticancer, Inc. | Skin vibration method for topical targeted delivery of beneficial agents into hair follicles |
US6162211A (en) | 1996-12-05 | 2000-12-19 | Thermolase Corporation | Skin enhancement using laser light |
US5810801A (en) | 1997-02-05 | 1998-09-22 | Candela Corporation | Method and apparatus for treating wrinkles in skin using radiation |
JP2001513697A (en) | 1997-02-24 | 2001-09-04 | スーペリア マイクロパウダーズ リミテッド ライアビリティ カンパニー | Aerosol method and apparatus, particle product, and electronic device manufactured from the particle product |
US6852252B2 (en) | 1997-03-12 | 2005-02-08 | William Marsh Rice University | Use of metalnanoshells to impede the photo-oxidation of conjugated polymer |
US20020061363A1 (en) | 2000-09-27 | 2002-05-23 | Halas Nancy J. | Method of making nanoshells |
US6344272B1 (en) | 1997-03-12 | 2002-02-05 | Wm. Marsh Rice University | Metal nanoshells |
US20020132045A1 (en) | 2000-09-27 | 2002-09-19 | Halas Nancy J. | Method of making nanoshells |
US7144627B2 (en) | 1997-03-12 | 2006-12-05 | William Marsh Rice University | Multi-layer nanoshells comprising a metallic or conducting shell |
US5935596A (en) | 1997-03-20 | 1999-08-10 | Chesebrough-Pond's Usa Co. | Delivery of skin benefit agents via adhesive strips |
US6235270B1 (en) | 1997-04-18 | 2001-05-22 | Showa Denko K.K. | Cosmetics, silica-coated metal oxide powder and production method therefor |
JP3570730B2 (en) | 1997-04-18 | 2004-09-29 | 昭和電工株式会社 | Cosmetic, silica-coated metal oxide powder and method for producing the same |
FR2762504B1 (en) | 1997-04-29 | 1999-09-10 | Cird Galderma | HAIR REMOVAL PROCESS |
US6165440A (en) | 1997-07-09 | 2000-12-26 | Board Of Regents, The University Of Texas System | Radiation and nanoparticles for enhancement of drug delivery in solid tumors |
US6168590B1 (en) | 1997-08-12 | 2001-01-02 | Y-Beam Technologies, Inc. | Method for permanent hair removal |
US6147982A (en) | 1997-12-30 | 2000-11-14 | Ericsson, Inc. | System and method for synchronizing acquisition for a code modulated communication system |
US6428811B1 (en) | 1998-03-11 | 2002-08-06 | Wm. Marsh Rice University | Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery |
US6699724B1 (en) | 1998-03-11 | 2004-03-02 | Wm. Marsh Rice University | Metal nanoshells for biosensing applications |
FR2779637B1 (en) | 1998-06-15 | 2000-09-01 | Oreal | PHOTOPROTECTIVE COSMETIC COMPOSITIONS CONTAINING A METAL OXIDE NANOPIGMENT AND AN ACRYLIC TERPOLYMER AND USE OF SUCH COMPOSITIONS FOR PROTECTING KERATINIC MATERIALS FROM ULTRAVIOLET RADIATION |
FR2780282B1 (en) | 1998-06-25 | 2001-04-13 | Oreal | ANHYDROUS COMPOSITION, USE IN COSMETICS, PHARMACY OR HYGIENE |
FR2780408B1 (en) | 1998-06-25 | 2000-07-28 | Oreal | ANHYDROUS COMPOSITION, USE IN COSMETICS, PHARMACY OR HYGIENE |
WO2000006244A2 (en) | 1998-07-30 | 2000-02-10 | Hainfeld James F | Loading metal particles into cell membrane vesicles and metal particle use for imaging and therapy |
DE19834819A1 (en) | 1998-08-01 | 2000-02-03 | Beiersdorf Ag | Emulsifier-free finely dispersed systems of the oil-in-water and water-in-oil type |
DE19842732A1 (en) | 1998-09-18 | 2000-03-23 | Beiersdorf Ag | Emulsifier-free finely dispersed systems of the oil-in-water and water-in-oil type |
US6838088B2 (en) | 1998-09-18 | 2005-01-04 | Beiersdorf Ag | Emulsifier-free finely disperse systems of the oil-in-water- and water-in-oil- type |
DE19842787A1 (en) | 1998-09-18 | 2000-03-23 | Beiersdorf Ag | Emulsifier-free finely dispersed systems of the oil-in-water and water-in-oil type |
DE19842730A1 (en) | 1998-09-18 | 2000-03-23 | Beiersdorf Ag | Emulsifier-free finely dispersed systems of the oil-in-water and water-in-oil type |
DE19842767A1 (en) | 1998-09-18 | 2000-03-23 | Beiersdorf Ag | Emulsifier-free finely dispersed systems of the oil-in-water and water-in-oil type |
BR9804597A (en) | 1998-11-10 | 2000-05-30 | Cosmeticos Natural Ind Com | Cosmetic composition in the form of powder. |
MY131835A (en) | 1998-11-20 | 2007-09-28 | Gen Hospital Corp | Permanent, removable tissue markings |
US6283956B1 (en) | 1998-11-30 | 2001-09-04 | David H. McDaniels | Reduction, elimination, or stimulation of hair growth |
US6676655B2 (en) | 1998-11-30 | 2004-01-13 | Light Bioscience L.L.C. | Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
FR2787023A1 (en) | 1998-12-11 | 2000-06-16 | Oreal | USE OF AN INDIGOID COMPOUND IN A COSMETIC COMPOSITION, IN PARTICULAR MAKE-UP, TO CONFER TO IT ANTI-MICROBIAL AND LONG-RING PROPERTIES. |
US6238650B1 (en) | 1999-05-26 | 2001-05-29 | Sol-Gel Technologies Ltd. | Sunscreen composition containing sol-gel microcapsules |
US6344050B1 (en) | 1998-12-21 | 2002-02-05 | Light Sciences Corporation | Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue |
CO5150202A1 (en) | 1998-12-31 | 2002-04-29 | Kimberly Clark Co | COMPOSITION OF FACIAL TISSU AND METHOD FOR USE FOR THE SECRETARY OF SKIN IRRITANTS OF THE NASAL SECRETION |
US6183773B1 (en) | 1999-01-04 | 2001-02-06 | The General Hospital Corporation | Targeting of sebaceous follicles as a treatment of sebaceous gland disorders |
US6534044B1 (en) | 1999-01-11 | 2003-03-18 | Showa Denko K.K | Cosmetic preparation, surface-hydrophobized silica-coated metal oxide particles, sol of silica-coated metal oxide, and processes for producing these |
US6491929B1 (en) | 1999-03-01 | 2002-12-10 | The General Hospital Corporation | Skin cosmetics |
FR2790386B1 (en) | 1999-03-04 | 2001-04-13 | Oreal | COSMETIC COMPOSITION IN POWDER FORM COMPRISING A PARTICULAR ESTER |
FR2792191B1 (en) | 1999-04-16 | 2004-04-30 | Oreal | COSMETIC COMPOSITION COMPRISING THE ASSOCIATION OF A PARTICULAR ESTER AND A SILICONE COMPOUND |
WO2000064537A1 (en) | 1999-04-27 | 2000-11-02 | The General Hospital Corporation Doing Business As Massachusetts General Hospital | Phototherapy method for treatment of acne |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
EP1066825A1 (en) | 1999-06-17 | 2001-01-10 | The Procter & Gamble Company | An anti-microbial body care product |
FR2795079B1 (en) | 1999-06-18 | 2001-08-03 | Oreal | SOLID AQUEOUS GEL COMPRISING A HYDROPHILIC GELLANT AND A PARTICULAR POLYETHYLENE GLYCOL, COMPOSITION COMPRISING THE SAME |
DE60027578T2 (en) | 1999-07-16 | 2007-01-25 | WM. Marsh Rice University, Houston | Method of detecting bioanalytes using metallic nanoshells |
JP4975919B2 (en) | 1999-07-16 | 2012-07-11 | ウィリアム・マーシュ・ライス・ユニバーシティ | Thermosensitive polymer / nanoshell composite for photothermally controlled drug administration |
US20030078499A1 (en) | 1999-08-12 | 2003-04-24 | Eppstein Jonathan A. | Microporation of tissue for delivery of bioactive agents |
US6355054B1 (en) | 1999-11-05 | 2002-03-12 | Ceramoptec Industries, Inc. | Laser system for improved transbarrier therapeutic radiation delivery |
US6530944B2 (en) | 2000-02-08 | 2003-03-11 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
JP5074652B2 (en) | 2000-02-08 | 2012-11-14 | ライスユニバーシティ | Optically active nanoparticles used in therapeutic and diagnostic methods |
US6436424B1 (en) | 2000-03-20 | 2002-08-20 | Biosphere Medical, Inc. | Injectable and swellable microspheres for dermal augmentation |
FR2806907B1 (en) | 2000-03-31 | 2003-01-24 | Oreal | COSMETIC COMPOSITION BASED ON NANOPARTICLES AND ORGANIC SILICON COMPOUNDS IN WATER |
US6821509B2 (en) | 2000-04-14 | 2004-11-23 | Cosmetica, Inc. | Nanoscopic hair care products |
US7758888B2 (en) | 2000-04-21 | 2010-07-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
FR2808998B1 (en) | 2000-05-19 | 2002-07-05 | Oreal | COSMETIC MAKEUP COMPOSITION COMPRISING A PARTICULAR BINDING PHASE |
FR2808999B1 (en) | 2000-05-19 | 2002-11-01 | Oreal | COSMETIC COMPOSITION IN POWDER FORM COMPRISING A PARTICULAR BINDER |
US6410603B1 (en) | 2000-06-02 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Active topical skin protectants using combinations of reactive nanoparticles and polyoxometalates or metal salts |
US6403653B1 (en) | 2000-06-02 | 2002-06-11 | The United States Of America As Represented By The Secretary Of The Army | Active topical skin protectants using reactive nanoparticles |
US6706032B2 (en) | 2000-06-08 | 2004-03-16 | Massachusetts Institute Of Technology | Localized molecular and ionic transport to and from tissues |
US7008647B2 (en) | 2001-04-23 | 2006-03-07 | Nucryst Pharmaceuticals Corp. | Treatment of acne |
CA2422865C (en) | 2000-08-16 | 2012-10-16 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Aminolevulinic acid photodynamic therapy for treating sebaceous gland disorders |
AU2001286189B8 (en) | 2000-09-11 | 2006-02-02 | Showa Denko K.K. | Sunscreen cosmetic composition |
FR2815869B1 (en) | 2000-10-27 | 2006-09-22 | Oreal | USE OF THERMOSTABILIZING MICROCAPSULES TO ENHANCE THE ACTIVITY OR PENETRATION OF COSMETIC OR PHARMACEUTICAL ACTIVE INGREDIENTS |
WO2002059226A2 (en) | 2000-11-03 | 2002-08-01 | Wm. Marsh Rice University | Partial coverage metal nanoshells and method of making same |
US20080183162A1 (en) | 2000-12-28 | 2008-07-31 | Palomar Medical Technologies, Inc. | Methods And Devices For Fractional Ablation Of Tissue |
DE10117336A1 (en) | 2001-04-06 | 2002-10-10 | Max Planck Gesellschaft | Novel light protection and skin care products through stabilized light protection components and reduction of damaging photo products |
US6811770B2 (en) | 2001-04-10 | 2004-11-02 | L'oreal | Two-coat make-up process and a make-up kit containing first and second compositions |
ATE322274T1 (en) | 2001-04-23 | 2006-04-15 | Nucryst Pharm Corp | MEDICINAL PRODUCTS OR PLASTERS CONTAINING A METAL SUCH AS SILVER GOLD, PLATINUM OR PALLADIUM AS AN ANTIMICROBIAL ACTIVE AND THEIR USE IN THE TREATMENT OF SKIN INFLAMMATION |
IL159131A0 (en) | 2001-06-01 | 2004-05-12 | Lipo Chemicals Inc | Method of using optically-activated particles in cosmetic preparations |
WO2002100444A1 (en) | 2001-06-08 | 2002-12-19 | Biosphere Medical Inc. | Colloidal metal labelled microparticles, their production and use |
FR2827160B1 (en) | 2001-07-16 | 2007-01-26 | Oreal | COSMETIC COMPOSITION COMPRISING A DISPERSION OF PARTICLES |
US7018396B2 (en) | 2001-08-07 | 2006-03-28 | New England Medical Center Hospitals, Inc. | Method of treating acne |
AU2002343413A1 (en) | 2001-09-26 | 2003-04-07 | Rice University | Optically-absorbing nanoparticles for enhanced tissue repair |
US7135054B2 (en) | 2001-09-26 | 2006-11-14 | Northwestern University | Nanoprisms and method of making them |
US6685927B2 (en) | 2001-09-27 | 2004-02-03 | Ceramoptec Industries, Inc. | Topical application of chromophores for hair removal |
US20030156991A1 (en) | 2001-10-23 | 2003-08-21 | William Marsh Rice University | Optomechanically-responsive materials for use as light-activated actuators and valves |
US7037513B1 (en) | 2005-01-31 | 2006-05-02 | Aquea Scientific Corporation | Bodywash additives |
US20030215638A1 (en) | 2001-11-05 | 2003-11-20 | Wm. Marsh Rice University | Reduced symmetry nanoparticles |
US20050053629A1 (en) | 2001-11-06 | 2005-03-10 | Yoshio Ueda | Skin lotion comprising aqueous dispersion of ultra-fine noble metal particles |
US20040147984A1 (en) | 2001-11-29 | 2004-07-29 | Palomar Medical Technologies, Inc. | Methods and apparatus for delivering low power optical treatments |
US20030118657A1 (en) | 2001-12-04 | 2003-06-26 | West Jennifer L. | Treatment of disease states characterized by excessive or inappropriate angiogenesis |
FR2834453B1 (en) | 2002-01-08 | 2006-01-06 | Oreal | COMPOSITION FOR MAKE-UP OR CARE OF KERATIN MATERIALS COMPRISING A NON-VOLATILE HYDROCARBON OIL, A PARTICULAR PHASE AND A PARTICULAR DISPERSING AGENT |
US20050177093A1 (en) | 2002-03-04 | 2005-08-11 | Barry Hart M. | Joint / tissue inflammation therapy and monitoring device |
US7081128B2 (en) | 2002-03-04 | 2006-07-25 | Hart Barry M | Phototherapy device and method of use |
AU2003298412A1 (en) | 2002-09-03 | 2004-03-29 | Zeptosens Ag | Analytical platform and identification method |
US20040219179A1 (en) | 2002-09-20 | 2004-11-04 | Mcdaniel David H. | Skin abrasive agents |
US7785623B2 (en) | 2002-10-01 | 2010-08-31 | Keller Brian C | Compositions and methods useful for the reduction of fine lines and wrinkles |
US20040151673A1 (en) | 2002-11-21 | 2004-08-05 | Societe L'oreal S.A. | Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles |
CA2508359A1 (en) | 2002-12-12 | 2004-06-24 | Nanosphere, Inc. | Direct snp detection with unamplified dna |
AU2003301111A1 (en) | 2002-12-20 | 2004-07-22 | Palomar Medical Technologies, Inc. | Apparatus for light treatment of acne and other disorders of follicles |
US20070231940A1 (en) | 2003-01-27 | 2007-10-04 | L'oreal S.A. | Composition and method of dyeing keratin fibers comprising luminescent semiconductive nanoparticles |
US20040253757A1 (en) | 2003-01-27 | 2004-12-16 | Luc Gourlaouen | Composition and method of dyeing keratin fibers comprising luminescent semiconductive nanoparticles |
US20050186565A1 (en) | 2003-02-10 | 2005-08-25 | American Environmental Systems, Inc. | Method and spectral/imaging device for optochemical sensing with plasmon-modified polarization |
US20040157237A1 (en) | 2003-02-10 | 2004-08-12 | Americal Environmental Systems, Inc. | Optochemical sensing with multi-band fluorescence enhanced by surface plasmon resonance |
US20090326358A1 (en) | 2003-02-14 | 2009-12-31 | American Environmental Systems, Inc | Non-invasive fast-response biodosimeter |
US20050203495A1 (en) | 2004-03-10 | 2005-09-15 | American Environmental Systems, Inc. | Methods and devices for plasmon enhanced medical and cosmetic procedures |
US8118032B2 (en) | 2003-02-14 | 2012-02-21 | American Environmental Systems, Inc. | Rapid cryo-heating devices and their applications |
AU2004223618A1 (en) | 2003-03-28 | 2004-10-07 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Sensor for detecting an analyte using silver nanoparticles |
US7659301B2 (en) | 2003-04-15 | 2010-02-09 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
US20050058672A1 (en) | 2003-09-14 | 2005-03-17 | Bioderm Research | Baby Care Skin Protectant Compositions for Diaper Rash |
US20050037034A1 (en) | 2003-05-05 | 2005-02-17 | Rhoades Dean L. | Method, apparatus, and composition for treating acne |
US20040253138A1 (en) | 2003-06-16 | 2004-12-16 | American Environmental Systems, Inc. | Plasmon enhanced body treatment and bacterial management |
AU2004248898B2 (en) | 2003-06-23 | 2010-03-18 | Beiersdorf Ag | Antimicrobial wounddressing |
JP2007531496A (en) | 2003-07-11 | 2007-11-08 | サロメッド,インコーポレイテッド | Multiplex molecular beacon assay for detecting pathogens |
WO2005007003A1 (en) | 2003-07-11 | 2005-01-27 | Reliant Technologies, Inc. | Method and apparatus for fractional photo therapy of skin |
US7226636B2 (en) | 2003-07-31 | 2007-06-05 | Los Alamos National Security, Llc | Gold-coated nanoparticles for use in biotechnology applications |
US20050058678A1 (en) | 2003-08-01 | 2005-03-17 | Audrey Ricard | Two-coat cosmetic product, uses thereof and makeup kit comprising the same |
US20050031658A1 (en) | 2003-08-01 | 2005-02-10 | L'oreal | Cosmetic skin treatment process and device for implementing such a process |
FR2858213B1 (en) | 2003-08-01 | 2006-02-10 | Oreal | COSMETIC TREATMENT METHOD FOR THE SKIN AND DEVICE FOR IMPLEMENTING SUCH A METHOD |
US20050031655A1 (en) | 2003-08-04 | 2005-02-10 | Schering Plough Healthcare Products, Inc. | Emulsion composition |
JP4125201B2 (en) | 2003-08-05 | 2008-07-30 | ロレアル | Cosmetic composition containing porous particles encapsulating an optically active substance |
FR2858768B1 (en) | 2003-08-11 | 2005-11-11 | Oreal | COSMETIC COMPOSITION COMPRISING HEART-ENVELOPE STRUCTURE PARTICLES |
FR2858766B1 (en) | 2003-08-11 | 2005-11-11 | Oreal | COSMETIC COMPOSITION COMPRISING STABILIZED METALLIC PARTICLES, POSSIBLY COATED |
FR2858765B1 (en) | 2003-08-11 | 2005-11-11 | Oreal | COSMETIC COMPOSITION COMPRISING HEART-ENVELOPE STRUCTURE PARTICLES |
FR2858767B1 (en) | 2003-08-11 | 2005-11-11 | Oreal | COSMETIC COMPOSITION COMPRISING PASSIVE METAL PARTICLES, POSSIBLY COATED |
US20050044642A1 (en) | 2003-09-02 | 2005-03-03 | Montagne Jeunesse Ltd | Hair colouring composition |
US7704754B2 (en) | 2004-01-27 | 2010-04-27 | American Environmental Systems, Inc. | Method of plasmon-enhanced properties of materials and applications thereof |
US7462496B2 (en) | 2003-09-08 | 2008-12-09 | American Environmental System, Inc. | Plasmon-enhanced marking of fragile materials and other applications thereof |
DE10342258A1 (en) | 2003-09-11 | 2005-04-07 | Josef Peter Prof. Dr.med. Guggenbichler | Antimicrobial composition for topical application for pharmaceutical or cosmetic purposes comprises elemental silver nanoparticles deposited on an inert support |
JP2007509098A (en) | 2003-10-24 | 2007-04-12 | ウエラ アクチェンゲゼルシャフト | Compositions for oxidative treatment of hair or skin, and fixing compositions and methods for permanent deformation of hair |
ES2311879T3 (en) | 2003-10-30 | 2009-02-16 | Mcneil-Ppc, Inc. | COMPOSITE MATERIALS INCLUDING EXFOLIATED NANOPARTICLES LOADED WITH METALS. |
DE10351611A1 (en) | 2003-11-05 | 2005-08-11 | Guggenbichler, Josef-Peter, Prof.Dr. | Liquid phase containing pure nano-particulate silver, useful in antimicrobial pharmaceutical or cosmetic preparations, obtained by eluting silver from (in)organic solid precursor with (in)organic liquid phase |
FR2861986B1 (en) | 2003-11-07 | 2007-12-14 | Oreal | MAKE-UP COMPOSITION COMPRISING EMULSION |
WO2005060610A2 (en) | 2003-12-11 | 2005-07-07 | The Trustees Of Columbia University In The City Ofnew York | Nano-sized particles, processes of making, compositions and uses thereof |
US7328708B2 (en) | 2003-12-23 | 2008-02-12 | United Laboratories & Manufacturing, Llc | LED multiplex source and method of use of for sterilization, bioactivation and therapy |
US20050137656A1 (en) | 2003-12-23 | 2005-06-23 | American Environmental Systems, Inc. | Acoustic-optical therapeutical devices and methods |
US7492458B2 (en) | 2004-01-05 | 2009-02-17 | American Environmental Systems, Inc. | Plasmon-enhanced display technologies |
DE102004002990A1 (en) | 2004-01-21 | 2005-08-18 | Robert Dr. Simmoteit | Material especially for medicinal or cosmetic skin treatment has nanoscalar structures and nano- or micro-scalar internal spaces allowing exchange, transfer or storage of e.g. fluids |
US20050187128A1 (en) | 2004-01-27 | 2005-08-25 | Guenaelle Martin | Cosmetic composition of the compact powder type |
FR2865386B1 (en) | 2004-01-27 | 2006-03-31 | Oreal | COSMETIC COMPOSITION WITH COMPACT POWDER |
FR2865385B1 (en) | 2004-01-27 | 2014-04-04 | Oreal | COSMETIC COMPOSITION OF COMPACT POWDER TYPE WITH SOLID FATTY PHASE |
US20050186235A1 (en) | 2004-01-27 | 2005-08-25 | Guenaelle Martin | Compact powder cosmetic compositions with a solid fatty phase |
EP1426033A3 (en) | 2004-01-29 | 2004-09-15 | Wella Aktiengesellschaft | Hair treatment emulsion comprising solid particles |
KR20050080805A (en) | 2004-02-11 | 2005-08-18 | 주식회사 태평양 | Silver/polymer colloidal nanocomposites and a process for preparation of the same, and cosmetic compositions containing the same |
US20050220741A1 (en) | 2004-03-22 | 2005-10-06 | Christophe Dumousseaux | Cosmetic composition comprising concave particles |
US7131446B2 (en) | 2004-03-25 | 2006-11-07 | Tang Kenneth Y | Light-triggered tattoo process |
WO2005092286A2 (en) | 2004-03-29 | 2005-10-06 | The University Of Houston System | Metallic nano-particles and discrete polymer-coated nano-particles |
JP5065005B2 (en) | 2004-04-01 | 2012-10-31 | ザ ジェネラル ホスピタル コーポレイション | Method and apparatus for dermatological treatment and tissue remodeling |
US20090130445A1 (en) | 2004-04-05 | 2009-05-21 | Henryk Malak | Nanostructured enhancer |
US7829073B2 (en) | 2004-04-06 | 2010-11-09 | L'oreal S.A. | Anhydrous cosmetic compositions comprising at least one polymeric gelling agent, at least one non-volatile oil, and poly(methyl methacrylate) particles |
US7276088B2 (en) | 2004-04-15 | 2007-10-02 | E.I. Du Pont De Nemours And Company | Hair coloring and cosmetic compositions comprising carbon nanotubes |
US20060257336A1 (en) | 2004-04-19 | 2006-11-16 | Veronique Ferrari | Cosmetic composition comprising silica particles, reflecting particles, and at least one polymer, preparative processes, and uses thereof |
FR2869803B1 (en) | 2004-05-10 | 2006-07-28 | Nanobiotix Sarl | ACTIVE PARTICLES, PREPARATION AND USES |
FR2873020A1 (en) | 2004-07-13 | 2006-01-20 | Oreal | Composition for manufacturing cosmetic product e.g. sun protection product comprises aqueous phase, hydrophilic inorganic nanopigments based on metal oxides and polyalkylene glycol with specified mean molecular mass; in physiological medium |
FR2873028B1 (en) | 2004-07-13 | 2008-04-04 | Oreal | AQUEOUS PHOTOPROTECTIVE COMPOSITION CONTAINING HYDROPHILIC METAL OXIDE NANOPIGMENTS AND A VINYLPYRROLIDONE HOMOPOLYMER; USES |
KR100684984B1 (en) | 2004-07-30 | 2007-03-02 | 한국화학연구원 | A proceeding method of free-rod and free-band type permanent |
WO2006135393A2 (en) | 2004-08-13 | 2006-12-21 | William Marsh Rice University | Method and system for optimizing surface enhanced raman scattering |
US20060078578A1 (en) | 2004-10-07 | 2006-04-13 | Sandewicz Robert W | Cosmetic compositions with montmorillonite stabilizing agent |
US20060083762A1 (en) | 2004-10-13 | 2006-04-20 | Gaelle Brun | Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles |
DE202004017052U1 (en) | 2004-11-02 | 2005-06-09 | Riesinger, Birgit | Device for wound treatment using negative pressure |
GB0424833D0 (en) | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
US7780955B2 (en) | 2004-11-12 | 2010-08-24 | L'oreal | Cosmetic composition with a lightening effect |
JP2008519642A (en) | 2004-11-12 | 2008-06-12 | ケーピーイー リミテッド | Nanoparticle-mediated ultrasound therapy and diagnostic imaging |
KR20070086176A (en) | 2004-12-22 | 2007-08-27 | 더 지렛트 캄파니 | Reduction of hair growth |
DE102005007482A1 (en) | 2005-02-17 | 2006-09-14 | Merck Patent Gmbh | Preparation containing nanoparticulate UV protection agent |
US20070196305A1 (en) | 2005-03-01 | 2007-08-23 | Hong Wang | Method for identifying hair conditioner-resistant hair-binding peptides and hair benefit agents therefrom |
EP1861465B1 (en) | 2005-03-23 | 2010-10-13 | DSM IP Assets B.V. | Chromophore coated metal oxide particles |
US7666494B2 (en) | 2005-05-04 | 2010-02-23 | 3M Innovative Properties Company | Microporous article having metallic nanoparticle coating |
WO2006122222A2 (en) | 2005-05-11 | 2006-11-16 | Georgia Tech Research Corporation | Shape tunable plasmonic nanoparticles |
US20070154903A1 (en) | 2005-06-23 | 2007-07-05 | Nanosphere, Inc. | Selective isolation and concentration of nucleic acids from complex samples |
KR100732249B1 (en) | 2005-07-18 | 2007-06-27 | 한국생명공학연구원 | Cosmetic Pigment Composition Containing Gold and/or Silver Nano-Particles |
US20070065387A1 (en) | 2005-09-16 | 2007-03-22 | Beck William A | Method for enhancing the effect of particulate benefit agents |
US20070078290A1 (en) | 2005-09-30 | 2007-04-05 | Esenaliev Rinat O | Ultrasound-based treatment methods for therapeutic treatment of skin and subcutaneous tissues |
JP5093903B2 (en) * | 2005-10-14 | 2012-12-12 | バイブ ナノ, インコーポレイテッド | Composite nanoparticles, nanoparticles and method for producing the same |
JP2009513596A (en) | 2005-10-26 | 2009-04-02 | チバ ホールディング インコーポレーテッド | Method for hair dyeing including application of composite pigments |
US20080288007A1 (en) | 2005-10-28 | 2008-11-20 | United Laboratories & Manufacturing, Llc | Hygienic-Therapeutic Multiplex Devices |
WO2007061781A1 (en) | 2005-11-18 | 2007-05-31 | 3M Innovative Properties Company | Coatable compositions, coatings derived therefrom and microarrays having such coatings |
US20070125383A1 (en) | 2005-12-02 | 2007-06-07 | Ko Chuan T | Facial mask |
FR2894467B1 (en) | 2005-12-08 | 2008-02-15 | Oreal | FOESENED COSMETIC COMPOSITION OF LOW DENSITY |
ES2485371T3 (en) | 2005-12-09 | 2014-08-13 | Dsm Ip Assets B.V. | New cosmetic or dermatological combinations, comprising modified titanium dioxide particles |
US20070160896A1 (en) | 2006-01-09 | 2007-07-12 | American Environmental Systems, Inc | Plasmonic fuel cell |
US8518445B2 (en) | 2006-01-20 | 2013-08-27 | Research Foundation Of The City University Of New York | Changing skin-color perception using quantum and optical principles in cosmetic preparations |
WO2007103721A2 (en) | 2006-03-01 | 2007-09-13 | The General Hospital Corporation | System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages |
US7790066B2 (en) | 2006-03-03 | 2010-09-07 | William Marsh Rice University | Nanorice particles: hybrid plasmonic nanostructures |
EP1998684A4 (en) | 2006-03-10 | 2014-09-17 | Massachusetts Inst Technology | Triggered self-assembly conjugates and nanosystems |
JP2009536162A (en) | 2006-05-04 | 2009-10-08 | ユニバーシティー オブ サウス オーストラリア | Drug release from nanoparticle-coated capsules |
US7776130B2 (en) | 2006-06-19 | 2010-08-17 | Northwestern University | pH-controlled photosynthesis of silver nanoprisms |
US8178202B2 (en) | 2006-06-21 | 2012-05-15 | William Marsh Rice University | Nonconcentric nanoshells with offset core in relation to shell and method of using the same |
JP4650354B2 (en) | 2006-06-28 | 2011-03-16 | 住友化学株式会社 | Method for regenerating unsaturated aldehyde and / or unsaturated carboxylic acid production catalyst, and method for producing unsaturated aldehyde and / or unsaturated carboxylic acid |
KR100815182B1 (en) | 2006-07-05 | 2008-03-19 | 주식회사 바이오프로젠 | The colored mask pack for cosmetics having microbial cellulose as a main component and its preparation method using metal nanoparticles |
GB0712287D0 (en) | 2007-06-22 | 2007-08-01 | Ucl Business Plc | Antimicrobial Conjugates |
JP2008069097A (en) | 2006-09-13 | 2008-03-27 | Aputo Kk | Mmp inhibitor containing transition metal fine particle |
US8285391B2 (en) | 2006-09-25 | 2012-10-09 | American Environmental Systems, Inc. | Hygienic-therapeutic conductive far-infrared devices |
DE102006049108B4 (en) | 2006-10-13 | 2019-05-02 | Agxx Intellectual Property Holding Gmbh | Bioactive, ruthenium-containing coatings, their use and method of coating a device |
US20080208179A1 (en) | 2006-10-26 | 2008-08-28 | Reliant Technologies, Inc. | Methods of increasing skin permeability by treatment with electromagnetic radiation |
JP4958082B2 (en) * | 2006-10-26 | 2012-06-20 | 独立行政法人産業技術総合研究所 | Nanoparticles for LPR sensor, method for producing nanoparticle, slurry, paint, coating film, and LPR sensor |
US20100172994A1 (en) | 2006-11-22 | 2010-07-08 | University Of Florida Research Foundation, Inc. | Nanoparticles for Protection of Cells from Oxidative Stress |
WO2008079898A1 (en) | 2006-12-20 | 2008-07-03 | Pharmwest, Inc. | Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions |
TW200846027A (en) | 2006-12-20 | 2008-12-01 | Avon Prod Inc | Nanocomposite pigments in a topical cosmetic application |
TW200846026A (en) | 2006-12-20 | 2008-12-01 | Avon Prod Inc | Nanocomposite pigments in a topical cosmetic application |
WO2008127743A2 (en) | 2007-01-05 | 2008-10-23 | William Marsh Rice University | Composition for targeted drug delivery and controlled release |
KR20090125243A (en) | 2007-02-01 | 2009-12-04 | 솔-겔 테크놀로지스 리미티드 | Compositions for topical application comprising a peroxide and retinoid |
US8057418B2 (en) | 2007-03-01 | 2011-11-15 | Nanospectra Biosciences, Inc. | Devices and methods for extracorporeal ablation of circulating cells |
WO2008106966A1 (en) | 2007-03-06 | 2008-09-12 | Christiansen Kaare | A method for non-therapeutic or therapeutic photodynamic skin treatment |
US9095522B2 (en) | 2007-03-19 | 2015-08-04 | Guerry L. Grune | High SPF transparent or translucent, cytoprotective, biodegradable, UV radiation resistant compositions |
US20080234535A1 (en) | 2007-03-23 | 2008-09-25 | American Environmental Systems, Inc | Device and method for thrombosis and pulmonary embolism |
US9358292B2 (en) | 2007-04-08 | 2016-06-07 | Immunolight, Llc | Methods and systems for treating cell proliferation disorders |
EP2142129A4 (en) | 2007-04-19 | 2011-04-20 | Miramar Labs Inc | Methods and apparatus for reducing sweat production |
DE102007020554A1 (en) | 2007-04-27 | 2008-10-30 | Henkel Ag & Co. Kgaa | Nucleic acid-containing cosmetic and / or pharmaceutical preparations for the treatment of epithelial covering tissue |
EP2644228A1 (en) | 2007-06-27 | 2013-10-02 | The General Hospital Corporation | Method and apparatus for optical inhibition of photodynamic therapy |
US20090012445A1 (en) | 2007-07-03 | 2009-01-08 | Henryk Malak | Device and method for In-Situ tissue regeneration |
TW200902073A (en) | 2007-07-06 | 2009-01-16 | Kuan-Jiuh Lin | Cosmetic composition |
US9023372B2 (en) | 2007-07-18 | 2015-05-05 | University Of Maryland | Metal-enhanced fluorescence nanoparticles |
WO2009012372A1 (en) | 2007-07-18 | 2009-01-22 | Advantageous Systems, Llc | Methods and apparatuses for detecting analytes in biological fluid of an animal |
CA2694357A1 (en) * | 2007-07-24 | 2009-02-26 | Northwestern University | Coated colloidal materials |
US20090053268A1 (en) | 2007-08-22 | 2009-02-26 | Depablo Juan J | Nanoparticle modified lubricants and waxes with enhanced properties |
FR2920965B1 (en) | 2007-09-13 | 2011-03-18 | Lvmh Rech | USE OF NITROGEN OXIDE NANOPARTICLES DOPED WITH NITROGEN AS A PROTECTIVE AGENT AGAINST ULTRAVIOLET RADIATION |
US20090071168A1 (en) | 2007-09-17 | 2009-03-19 | American Environmental Systems, Inc. | Device and methods for internal cooling of an integrated circuit (IC) |
EP2205282A2 (en) | 2007-09-24 | 2010-07-14 | Bar-Ilan University | Polymer nanoparticles coated by magnetic metal oxide and uses thereof |
US20100224026A1 (en) | 2007-10-04 | 2010-09-09 | Margaret Elizabeth Brennan Fournet | A process for synthesising silver nanoparticles |
BRPI0819218A2 (en) | 2007-11-05 | 2015-05-05 | Puretech Ventures | Methods, kits and compositions for administering pharmaceutical compounds |
US20090123509A1 (en) | 2007-11-08 | 2009-05-14 | Cory Berkland | Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds |
WO2009064964A2 (en) | 2007-11-15 | 2009-05-22 | The University Of California | Switchable nano-vehicle delivery systems, and methods for making and using them |
CN101182578B (en) * | 2007-11-19 | 2011-04-20 | 中国科学院上海微系统与信息技术研究所 | DNA detection method based on gene chip with nanometer gold detecting probe |
WO2009070282A1 (en) | 2007-11-26 | 2009-06-04 | Stc.Unm | Active nanoparticles and method of using |
CN101980693A (en) | 2007-12-05 | 2011-02-23 | 莱雅公司 | Cosmetic make-up and/or care method using a siloxane resin and a non-volatile oil |
TWI468185B (en) | 2007-12-27 | 2015-01-11 | Avon Prod Inc | Gel technology suitable for use in cosmetic compositions |
TWI411448B (en) | 2007-12-27 | 2013-10-11 | Avon Prod Inc | Optical blurring pigment composition suitable for use in cosmetics |
JPWO2009084743A1 (en) | 2007-12-28 | 2011-05-19 | ミズ株式会社 | External preparation for treatment or prevention |
US20090177122A1 (en) | 2007-12-28 | 2009-07-09 | Celleration, Inc. | Methods for treating inflammatory skin disorders |
SG187395A1 (en) | 2008-01-03 | 2013-02-28 | Univ Singapore | Nanostructures, methods of preparing and uses thereof |
ES2326721B1 (en) | 2008-01-04 | 2010-07-16 | Endor Nanotechnologies, S.L. | CONJUGATE OF HIALURONIC ACID FOR COSMETIC TREATMENT AND PREPARATION PROCEDURE. |
US9056053B2 (en) | 2008-01-08 | 2015-06-16 | Avon Products, Inc | Nanoparticle compositions providing enhanced color for cosmetic formulations |
WO2009091597A2 (en) | 2008-01-16 | 2009-07-23 | Nanospectra Biosciences, Inc. | Treatments of disease or disorders using nanoparticles for focused hyperthermia to increase therapy efficacy |
US20100284924A1 (en) | 2008-01-23 | 2010-11-11 | The Regents Of The University Of California | Nano-devices having impellers for capture and release of molecules |
DE102008008522A1 (en) | 2008-02-11 | 2009-08-13 | Magforce Nanotechnologies Ag | Implantable nanoparticle-containing products |
EP2090285A1 (en) | 2008-02-18 | 2009-08-19 | B.R.A.I.N. Biotechnology Research and Information Network AG | Means and methods for controlling commensales |
WO2009105209A1 (en) | 2008-02-19 | 2009-08-27 | Health Research, Inc. | Silica nanoparticles postloaded with photosensitizers for drug delivery in photodynamic therapy |
DE102008013143A1 (en) | 2008-03-07 | 2009-09-10 | Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. | Producing a silver containing coating agent, useful e.g. for coating temperature sensitive materials e.g. wood, comprises reacting an alkoxysilane, a soluble silver salt and an amine compound in an aqueous solution or in a solvent mixture |
US20110059023A1 (en) | 2008-03-19 | 2011-03-10 | Tunnell James W | Narrowband imaging using near-infrared absorbing nanoparticles |
CA3095369C (en) | 2008-04-04 | 2023-09-26 | Immunolight, Llc | Non-invasive systems and methods for in-situ photobiomodulation |
EP2279054A2 (en) * | 2008-04-25 | 2011-02-02 | National University of Ireland, Galway | An ink comprising nanostructures |
US20110091572A1 (en) | 2008-06-05 | 2011-04-21 | Davidson Richard E | Acne treatment compositions comprising nanosilver and uses |
US8130438B2 (en) | 2008-07-03 | 2012-03-06 | Ajjer Llc | Metal coatings, conductive nanoparticles and applications of the same |
US20100016782A1 (en) | 2008-07-16 | 2010-01-21 | John Erich Oblong | Method of Regulating Hair Growth |
US20100056485A1 (en) | 2008-08-28 | 2010-03-04 | Snu R&Db Foundation | Nanosoap containing silver nanoparticles |
US20100057068A1 (en) | 2008-08-29 | 2010-03-04 | Kwangyeol Lee | Gold nanostructure and methods of making and using the same |
CN102186848B (en) | 2008-09-18 | 2014-11-12 | 奥斯拜客斯制药有限公司 | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
US20130023714A1 (en) | 2008-10-26 | 2013-01-24 | Board Of Regents, The University Of Texas Systems | Medical and Imaging Nanoclusters |
US20100104652A1 (en) | 2008-10-27 | 2010-04-29 | University Of Arkansas | Use of advanced nanomaterials for increasing sepecific cell functions |
WO2010056881A1 (en) * | 2008-11-12 | 2010-05-20 | Solutions Biomed, Llc | Multi-chamber container system for storing and mixing liquids |
US20100119610A1 (en) | 2008-11-12 | 2010-05-13 | Concurrent Analytical, Inc. | Packaged pegylated gold nanoparticles |
AU2009314147B2 (en) | 2008-11-12 | 2015-12-24 | The Trustees Of The University Of Pennsylvania | Fibroblast growth factor-9 promotes hair follicle regeneration after wounding |
PT2376215T (en) | 2008-12-11 | 2019-01-17 | Univ California | Filtration membrane |
WO2010073260A1 (en) * | 2008-12-26 | 2010-07-01 | Jawaharlal Nehru Centre For Advanced Scientific Research | Sers active paper substrate, a process and a method thereof |
EA019739B1 (en) | 2009-02-10 | 2014-05-30 | Скайлайт Текнолоджи Лимитед | A pharmaceutical composition and method for increasing hair growth |
CN102365074A (en) | 2009-03-27 | 2012-02-29 | 莱雅公司 | Powder composition containing fusiform particles for cosmetic use |
EP2410973A1 (en) | 2009-03-27 | 2012-02-01 | L'Oréal | Liquid composition containing fusiform particles for cosmetic use |
DE102009002267A1 (en) | 2009-04-07 | 2010-10-14 | Henkel Ag & Co. Kgaa | Powdered composition for shaping and luster of keratinic fibers |
IE20100205A1 (en) * | 2009-04-08 | 2010-11-10 | Nat Univ Ireland | Silver nanoplates |
WO2010116346A1 (en) * | 2009-04-08 | 2010-10-14 | National University Of Ireland, Galway | Silver nanoplates |
TWI511756B (en) | 2009-04-21 | 2015-12-11 | 伊穆諾萊特公司 | Pharmaceutical composition or kit for modifying a target structure which mediates or is associated with a biological activity |
CA2763221C (en) | 2009-05-26 | 2019-01-08 | The General Hospital Corporation | Method and apparatus for dermal delivery of a substance |
JP2010275566A (en) | 2009-05-26 | 2010-12-09 | Panasonic Electric Works Co Ltd | Metal particulate generator and hair care unit provided with the same |
US9504824B2 (en) | 2009-06-23 | 2016-11-29 | Board Of Regents, The University Of Texas System | Noninvasive therapies in the absence or presence of exogenous particulate agents |
KR101358374B1 (en) | 2009-07-30 | 2014-02-05 | 알마 레이저 엘티디. | A sonotrode |
KR101865888B1 (en) | 2009-09-09 | 2018-06-08 | 삼성전자주식회사 | Particles including nanoparticles, uses thereof, and methods |
US8591924B2 (en) | 2009-09-23 | 2013-11-26 | Avon Products, Inc. | High-coverage and natural-looking cosmetic compositions and uses thereof |
US8652534B2 (en) | 2009-10-14 | 2014-02-18 | Berry Pharmaceuticals, LLC | Compositions and methods for treatment of mammalian skin |
US20110097285A1 (en) | 2009-10-28 | 2011-04-28 | American Environmental Systems, Inc. | Multiplex dentifrice compositions |
WO2011060033A1 (en) | 2009-11-10 | 2011-05-19 | Immunolight, L.L.C. | Up and down coversion systems for production of emitted light from various energy sources including radio frequency, microwave energy and magnetic induction sources for upconversion |
US20110111002A1 (en) | 2009-11-12 | 2011-05-12 | Calin Viorel Pop | Transport and delivery of glutathione into human cells using gold nanoparticles |
FR2952533B1 (en) | 2009-11-13 | 2012-01-13 | Oreal | COSMETIC COMPOSITION FOR THE CONDITIONING OF HAIR CONTAINING A MIXTURE OF HOLLOW PARTICLES, STARCH AND CATIONIC SURFACTANT |
MX2012005503A (en) | 2009-11-16 | 2012-06-14 | Basf Se | Metal oxide nanocomposites for uv protection. |
US9308582B2 (en) | 2009-12-24 | 2016-04-12 | Yi Sun | Solution stable and chemically reactive metallic nanoparticles |
CA2788980A1 (en) | 2010-02-07 | 2011-08-11 | J.P.M.E.D. Ltd. | Hair follicle targeting compositions |
ES2384060B1 (en) | 2010-03-24 | 2013-09-23 | Lipotec S.A. | LIPID NANOPARTICLES CAPSULES. |
EP2519215B1 (en) | 2010-03-31 | 2016-08-24 | Colgate-Palmolive Company | Oral care composition |
ES2548988T3 (en) | 2010-03-31 | 2015-10-22 | Colgate-Palmolive Company | Composition for oral care |
US20130225901A1 (en) | 2010-04-05 | 2013-08-29 | Nanospectra Biosciences, Inc. | Enhancement of radiation therapy by targeted high-z nanoparticles |
US20110306955A1 (en) | 2010-04-12 | 2011-12-15 | Advalight Aps | Multiwavelength laser apparatus for skin treatment |
US9572880B2 (en) | 2010-08-27 | 2017-02-21 | Sienna Biopharmaceuticals, Inc. | Ultrasound delivery of nanoparticles |
US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
FR2964663B1 (en) | 2010-09-14 | 2013-10-11 | Oreal | COSMETIC COMPOSITION COMPRISING COLORING MATTER, COLORING MATERIAL, AND COSMETIC TREATMENT PROCESS |
ES2386177B1 (en) | 2010-09-21 | 2013-09-23 | Lipotec, S.A. | NANOCAPSULES CONTAINING MICROEMULSIONS |
AU2011324794B2 (en) | 2010-11-02 | 2015-09-03 | Indian Institute Of Technology, Delhi | Blue coloured aqueous dispersion of silver nanoparticles a process for preparation and compositions thereof |
FR2967348B1 (en) | 2010-11-17 | 2013-05-10 | Oreal | COSMETIC COMPOSITION FOR EYE CONTOUR |
US20130338545A1 (en) | 2010-12-14 | 2013-12-19 | Slender Medical Ltd. | Ultrasound skin treatment |
US8197471B1 (en) | 2011-02-14 | 2012-06-12 | Samuel Harry Tersigni | Core-excited nanoparticles and methods of their use in the diagnosis and treatment of disease |
US8784895B2 (en) | 2011-03-15 | 2014-07-22 | Northwestern University | Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same |
TWI458504B (en) | 2011-05-02 | 2014-11-01 | Univ Nat Cheng Kung | Patch for transdermal drug delivery and method of controlling drug release of the same by near-ir |
US9241921B2 (en) | 2011-05-02 | 2016-01-26 | Pankaj Modi | Photosensitizer composition for treating skin disorders |
US9956028B2 (en) | 2011-05-09 | 2018-05-01 | Innovolink, Llc | Apparatus and method for heating biological targets |
WO2012170909A1 (en) | 2011-06-10 | 2012-12-13 | The Research Foundation Of State University Of New York | Method and device for non-invasive acoustic stimulation of stem cells and progenitor cells in a patient |
US20130177504A1 (en) | 2011-06-17 | 2013-07-11 | Annuary Healthcare, Inc. | Nanoscale Particle Formulations and Methods |
US10058500B2 (en) | 2011-11-30 | 2018-08-28 | Fundació Institut De Ciències Fotòniques | Method for enhanced photoepilation based on metallic nano-complexes |
WO2013106998A1 (en) | 2012-01-17 | 2013-07-25 | L'oreal | Colour changing composition in o/w emulsion form |
WO2013107000A1 (en) | 2012-01-17 | 2013-07-25 | L'oreal | Colour changing composition |
WO2013107001A1 (en) | 2012-01-17 | 2013-07-25 | L'oreal | Colour changing composition with uv filter(s) |
WO2013107002A1 (en) | 2012-01-17 | 2013-07-25 | L'oreal | Colour changing composition with polyols |
WO2013106996A1 (en) | 2012-01-17 | 2013-07-25 | L'oreal | Colour changing composition in gel form |
WO2013106999A1 (en) | 2012-01-17 | 2013-07-25 | L'oreal | Colour changing composition with alcohol |
US20130323305A1 (en) | 2012-04-20 | 2013-12-05 | The General Hospital Corporation | Compositions and methods comprising energy absorbing materials for follicular delivery |
US20130315999A1 (en) | 2012-04-20 | 2013-11-28 | The General Hospital Corporation | Compositions and methods comprising energy absorbing compoundfs for follicular delivery |
ES2904817T3 (en) | 2012-04-26 | 2022-04-06 | Oreal | Cosmetic composition comprising mattifying fillers and a silane |
CA2872658C (en) | 2012-05-08 | 2021-05-04 | The Regents Of The University Of California | Fine spatiotemporal control of thermolysis and lipolysis using nir light |
WO2014026142A1 (en) | 2012-08-10 | 2014-02-13 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and compostions for tissue adhesives |
WO2014052973A1 (en) | 2012-09-28 | 2014-04-03 | Stelo Technologies | Methods of making silver nanoparticles and their applications |
US9249334B2 (en) | 2012-10-11 | 2016-02-02 | Nanocomposix, Inc. | Silver nanoplate compositions and methods |
WO2014066850A2 (en) | 2012-10-26 | 2014-05-01 | Nanocomposix, Inc. | Metastable silver nanoparticle composites |
US20140120167A1 (en) | 2012-10-30 | 2014-05-01 | William Marsh Rice University | Multifunctional chemo- and mechanical therapeutics |
US9624282B2 (en) | 2012-11-26 | 2017-04-18 | The Curators Of The University Of Missouri | Microdystrophin peptides and methods for treating muscular dystrophy using the same |
EP3804591A1 (en) | 2013-01-07 | 2021-04-14 | Filip Sedic | Skin cleanser |
CA2906887A1 (en) | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Methods of delivering nanoshells into sebaceous glands |
US20150045723A1 (en) | 2013-08-09 | 2015-02-12 | Dilip Paithankar | Compositions, methods and apparatus for use with energy activatible materials |
EP3071211A1 (en) | 2013-11-18 | 2016-09-28 | Instructive Color, LLC | Metastable silver nanoparticle composites with color indicating properties |
US9279270B1 (en) | 2014-01-08 | 2016-03-08 | John Christian Treister | System for affixing a blanket to ground |
US10709897B2 (en) | 2014-01-10 | 2020-07-14 | Sebacia, Inc. | Treatment intervals for use of compositions comprising energy absorbing materials for dermatological applications |
CN106458555A (en) | 2014-01-10 | 2017-02-22 | 斯巴卡有限公司 | Particle containers and delivery applicators |
EP3091927A4 (en) | 2014-01-10 | 2017-09-27 | Sebacia, Inc. | Sub-surface array of absorber materials, and light irradiation therapy |
WO2016075747A1 (en) | 2014-11-10 | 2016-05-19 | 日本たばこ産業株式会社 | Non-combusting flavor inhaler and package |
CN108430431A (en) | 2015-11-13 | 2018-08-21 | 丝芭霞公司 | The method for handling skin with plasma nano particle |
-
2013
- 2013-10-08 US US14/048,996 patent/US9249334B2/en active Active - Reinstated
- 2013-10-08 BR BR112015008063-4A patent/BR112015008063A2/en not_active Application Discontinuation
- 2013-10-08 CA CA2887687A patent/CA2887687A1/en not_active Abandoned
- 2013-10-08 ES ES13845112.5T patent/ES2629903T3/en active Active
- 2013-10-08 WO PCT/US2013/063920 patent/WO2014058904A1/en active Application Filing
- 2013-10-08 EP EP17174462.6A patent/EP3272388A1/en active Pending
- 2013-10-08 JP JP2015536844A patent/JP6325552B2/en not_active Expired - Fee Related
- 2013-10-08 MX MX2015004524A patent/MX2015004524A/en active IP Right Grant
- 2013-10-08 EP EP13845112.5A patent/EP2906286B1/en not_active Not-in-force
- 2013-10-08 CN CN201380061329.2A patent/CN104822412B/en active Active
- 2013-10-08 KR KR1020157012210A patent/KR102154207B1/en active IP Right Grant
- 2013-10-08 KR KR1020207025520A patent/KR20200106984A/en not_active Application Discontinuation
- 2013-10-08 IL IL305614A patent/IL305614A/en unknown
- 2013-10-08 RU RU2015112182A patent/RU2646809C2/en active
- 2013-10-08 IL IL296593A patent/IL296593B2/en unknown
- 2013-10-08 CN CN201810332967.8A patent/CN108480620A/en active Pending
- 2013-10-08 AU AU2013329450A patent/AU2013329450B2/en active Active
- 2013-10-08 PL PL13845112T patent/PL2906286T3/en unknown
- 2013-10-08 DK DK13845112.5T patent/DK2906286T3/en active
-
2015
- 2015-04-02 IL IL238112A patent/IL238112B/en active IP Right Grant
- 2015-04-08 US US14/681,379 patent/US9212294B2/en not_active Expired - Fee Related
- 2015-11-20 US US14/947,508 patent/US9526745B2/en active Active
- 2015-12-18 US US14/974,987 patent/US20160101130A1/en not_active Abandoned
-
2016
- 2016-01-26 HK HK16100850.1A patent/HK1212931A1/en not_active IP Right Cessation
- 2016-12-09 US US15/374,942 patent/US10688126B2/en active Active
-
2017
- 2017-08-28 AU AU2017219126A patent/AU2017219126B2/en active Active
-
2018
- 2018-04-12 JP JP2018076470A patent/JP6574867B2/en not_active Expired - Fee Related
- 2018-10-03 AU AU2018241065A patent/AU2018241065B2/en active Active
- 2018-10-17 HK HK18113304.4A patent/HK1254167A1/en unknown
-
2019
- 2019-08-19 JP JP2019149791A patent/JP2020020044A/en active Pending
-
2020
- 2020-05-27 IL IL274971A patent/IL274971B2/en unknown
- 2020-06-16 US US16/902,455 patent/US11583553B2/en active Active
- 2020-07-02 AU AU2020204436A patent/AU2020204436B2/en active Active
-
2022
- 2022-10-27 AU AU2022259793A patent/AU2022259793A1/en active Pending
- 2022-12-27 US US18/089,047 patent/US20230139868A1/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2885366A (en) * | 1956-06-28 | 1959-05-05 | Du Pont | Product comprising a skin of dense, hydrated amorphous silica bound upon a core of another solid material and process of making same |
US20070158611A1 (en) * | 2005-11-08 | 2007-07-12 | Oldenburg Steven J | Compositions comprising nanorods and methods of making and using them |
US20120059307A1 (en) * | 2010-08-27 | 2012-03-08 | Sienna Labs, Inc. | Compositions and Methods for Targeted Thermomodulation |
Non-Patent Citations (2)
Title |
---|
Chen et al., "Silver Nanodisks: Synthesis, Characterization, and Self-Assembly", J Phys Chem 106: 10777-10781 (2002) * |
Hao et al., "Synthesis and optical properties of anisotropic metal nanoparticles", J Fluorescence 14: 331-341 (2002) * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220072535A1 (en) * | 2019-04-30 | 2022-03-10 | Hewlett-Packard Development Company, L.P. | Microfluidic devices |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9249334B2 (en) | Silver nanoplate compositions and methods | |
US20140120168A1 (en) | Metastable silver nanoparticle composites | |
Shevtsova et al. | Temperature-responsive hybrid nanomaterials based on modified halloysite nanotubes uploaded with silver nanoparticles | |
WO2008100163A1 (en) | Method of manufacturing silver nanoparticles, cellulosic fibers and nanofibers containing silver nanoparticles, fibers and nanofibers containing silver nanoparticles, use of silver nanoparticles to the manufacture of cellulosic fibers and nanofibers, and wound dressing containing silver nanoparticles | |
Pawar et al. | A comprehensive patent review on β-cyclodextrin cross-linked nanosponges for multiple applications | |
CN106317386A (en) | Preparing method of antibacterial polylactic acid material |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: NANOCOMPOSIX, INC., CALIFORNIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:OLDENBURG, STEVEN J.;MIRANDA, MARTIN G.;SEBBA, DAVID S.;SIGNING DATES FROM 20131227 TO 20131230;REEL/FRAME:038346/0544 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: FINAL REJECTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |