US20150018761A1 - Seal Structures for Wet/Dry Automatic Injectors - Google Patents
Seal Structures for Wet/Dry Automatic Injectors Download PDFInfo
- Publication number
- US20150018761A1 US20150018761A1 US13/939,647 US201313939647A US2015018761A1 US 20150018761 A1 US20150018761 A1 US 20150018761A1 US 201313939647 A US201313939647 A US 201313939647A US 2015018761 A1 US2015018761 A1 US 2015018761A1
- Authority
- US
- United States
- Prior art keywords
- compartment
- seal structure
- chamber
- automatic injection
- injection device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3145—Filters incorporated in syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/348—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub snap lock, i.e. upon axial displacement of needle assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
- A61M2005/287—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst by displacing occluding plugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
- A61M2005/3106—Plugs for syringes without needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3293—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle hub
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/343—Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub
Definitions
- the invention relates to drug delivery devices. More particularly, the invention relates to automatic injector assemblies capable of mixing two components of a medicament and then delivering the mixed medicament to an injection site.
- An automatic injector is a device that enables intramuscular (IM) or subcutaneous administration of a dosage of medicament.
- the medicament is stored as a liquid formulation which is then injected intramuscularly.
- An advantage of automatic injectors is that they contain a measured dosage of a liquid medicament in a sealed sterile cartridge. As such automatic injectors allow for quick and simple IM injection of a liquid medicament in emergency situations without the need for measuring dosages.
- Another advantage of automatic injectors is that the administration of the medicament is accomplished without the user initially seeing the hypodermic needle through which the medicament is delivered, and without requiring the user to manually force the needle into the patient. This is particularly advantageous when the medicament is being self-administered.
- One aspect of the invention relates to an automatic injection device for automatically administering a medicament upon actuation thereof, where the device includes a housing, a chamber disposed in the housing having a first compartment and a second compartment, and a seal structure between the first compartment and the second compartment.
- the seal structure is initially in a sealing condition that seals the first compartment from the second compartment, and includes a plug and an outer sealing member that forms a peripheral seal with an interior wall of the chamber.
- the plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment through the seal structure.
- the plug also maintains the same orientation with respect to the outer sealing member as the plug moves to convert the seal structure from the sealing condition to the mixing condition.
- the automatic injection device further includes a needle assembly connected to the first compartment, and an activation assembly carried by the housing. Activation of the activation assembly causes: (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.
- Another aspect of the invention relates to an automatic injection device containing a medicament for automatically administering the medicament upon actuation thereof
- the device includes a housing, a chamber disposed in the housing having a first compartment and a second compartment, and a seal structure between the first compartment and the second compartment.
- the seal structure is initially in a sealed condition to maintain the first compartment separate from the second compartment, where the seal structure converts to a mixing condition in response to activation of the device.
- the seal structure includes an outer sealing member that forms a peripheral seal with an interior wall of the chamber, and a plug spaced radially inward from the outer sealing member.
- the plug is in a first position where it is sealingly engaged with a surface of the outer sealing member to form a liquid-tight seal between the first and second compartments when the seal structure is in the sealed condition.
- the plug is in a second position when the seal structure is in the mixing condition.
- the plug then remains stationary in the second position as the liquid component flows through the seal structure and thereafter.
- the automatic injection device further includes a needle assembly connected to the chamber and an activation assembly disposed in the housing. Activation of the activation assembly causes; (1) pressurization of the first compartment, (2) the seal structure to convert from the sealed condition to the mixing condition, and (3) contents of the first and second compartments to be mixed and forced through the needle assembly.
- FIG. 1 is a longitudinal cross-sectional view of a wet/dry automatic injector assembly in accordance with an embodiment of the present invention
- FIGS. 2A-2B illustrate longitudinal cross-sectional views of needle support assemblies in accordance with certain embodiments of the present invention
- FIGS. 3A-3D illustrate cross-sectional side views of various cartridge or chamber configurations and corresponding needle assembly options according to certain embodiments of the present invention
- FIG. 4 is an enlarged partial cross-sectional side view of a needle assembly/cartridge engagement according to another embodiment
- FIGS. 5A-5D illustrate cross-sectional side views of various embodiments of a seal structure according to the present invention
- FIG. 6A is a longitudinal cross-sectional side view of a seal structure in accordance with another embodiment of the present invention, wherein the movable sealing plug is in a closed sealing position blocking the flow of the liquid injection solution;
- FIG. 6B is a longitudinal cross sectional side view of seal structure similar to 6 A, but showing the movable sealing plug in an open by-pass position permitting the flow of the liquid injection solution;
- FIG. 6C is a lateral cross sectional view of the seal structure of the present invention taken through the line 6 C- 6 C in FIG. 6A ;
- FIG. 6D is a lateral cross sectional view of the seal structure of the present invention taken through the line 6 D- 6 D in FIG. 6B ;
- FIG. 7 is a longitudinal cross-sectional view of a wet/dry automatic injector cartridge or chamber configuration in accordance with another embodiment of the present invention.
- FIGS. 8A and 8B are longitudinal cross sectional views of two additional embodiments of seal structures in accordance with the present invention.
- FIG. 9 is a longitudinal cross-sectional view of a chamber and needle assembly according to a further embodiment of the invention.
- FIG. 10 is a perspective view of an outer sealing member in the chamber and needle assembly of FIG. 9 ;
- FIG. 11 is a front elevational view of the outer sealing member of FIG. 10 ;
- FIG. 12 is a longitudinal sectional view of the outer sealing member of FIG. 10 , taken through Line 12 - 12 of FIG. 11 ;
- FIG. 13 is a perspective view of a tapered insert in the chamber and needle assembly of FIG. 9
- FIG. 14 is a front elevational view of the tapered insert of FIG. 13 ;
- FIG. 15 is a longitudinal sectional view of the tapered insert in the chamber and needle assembly of FIG. 13 , taken through Line 15 - 15 of FIG. 14 ;
- FIG. 16 is a longitudinal sectional view of a portion of the needle assembly of FIG. 9 , illustrating a chamber behind die needle assembly filter;
- FIGS. 17A-17F are sectional and partially sectional views of a chamber illustrating a process for filling it with dry and liquid medicament components.
- the present invention is described in connection with a push button type auto injector, whereby the user removes an end cap assembly and presses a button to trigger the injection process.
- the present invention is not limited to push button type automatic injectors; rather, it is contemplated that the present invention may be incorporated into a nose activated auto injector, as described for example in U.S. Pat. No. 5,354,286, the disclosure of which is hereby incorporated herein by reference for such teaching.
- FIG. 1 is a longitudinal cross-sectional view of an automatic injector assembly 10 in accordance with an embodiment of the present invention.
- the automatic injector assembly 10 includes a generally hollow tubular plastic housing 110 .
- the housing 110 includes an injection end 111 and an activation end 112 , as shown in FIG. 1 .
- an actuator assembly 120 is inserted into the rearward end of the housing 110 .
- the actuator assembly 120 is received within the housing 110 until flange 115 of a sleeve member 144 is captured within an annular groove 117 on the interior surface of housing 110 .
- a removable safety cap 130 is releasably secured to the actuator assembly 120 .
- the actuator assembly 120 may be of any conventional type as known in the art, such as that disclosed in commonly assigned U.S. Pat. No. 5,391,151 hereby incorporated by reference.
- the present invention employs a rear-end activating device, similar to that in the aforementioned U.S. Pat. No. 5,391,151, and is therefore only briefly described herein.
- the actuator assembly 120 includes an activation button sleeve 132 having internal activation surfaces 134 .
- the activation assembly further includes a plastic collet 122 with a split rearward portion forming spring fingers 136 as known in the art
- the safety cap 130 has a pin portion 138 that extends between the spring fingers 136 so as to keep them spread apart when the injector is in a storage condition.
- the spring fingers 136 terminate in semi-conical configurations including rearwardly facing sloping surfaces 139 and forwardly facing flat surfaces 142 .
- the collet 122 is surrounded by a cylindrical sleeve 144 having inwardly extending flange 146 at the rearward end thereof.
- the collet 122 has a forward annular flange 148 .
- a coil spring 250 surrounds the collet 122 and is compressed between the flange 148 and flange 146 .
- the collet flat surfaces 142 are retained in engagement with the rearwardly facing surfaces of the flange 146 , and thus prevented from moving off of the flange surfaces by the pin 138 when the injector is stored.
- the safety pin 130 is manually pulled off of the rear end of the injector, thus removing pin 138 from between the fingers 136 .
- the activation button 132 can then be pushed inwardly, and as a result of the activation surfaces thereof, 134 engages the sloping surfaces 139 of the spring fingers 136 . This forces the spring fingers 136 inwards toward one another and off of the retaining surfaces of the flange 146 .
- the compressed spring 250 is then free to release the stored energy therein to move the collet 122 forwardly under the force of the spring to affect an injection operation as will be described later in more detail.
- the actuator assembly 120 may be of any type known in the automatic injector art that employs releasable stored energy. For example, rather than employing a spring, it may employ a charge of compressed gas.
- a vial or chamber 150 Located within the interior of the housing 110 is a vial or chamber 150 , preferably made of glass, for containing both a liquid injection solution and a dry medicament, or other types of medicament portions, as appropriate.
- the chamber 150 is preferably a hollow cylinder, with a smooth cylindrical inner surface.
- the liquid injection solution is located within a wet portion or compartment 151 of the chamber 150 .
- the dry medicament is located within a dry portion 152 or compartment of the chamber 150 .
- the dry medicament may be in powder, freeze-dried, or any other solid formulation known in the art
- a seal structure 160 engages the interior side walls of the chamber 150 to seal the dry portion 152 from the wet portion 151 and to prevent seepage of the liquid injection solution into the dry portion 152 prior to activation of the injector assembly.
- a needle assembly 140 mounts to the forward end of vial or chamber 150 to inject the medicament upon activation of the injector assembly.
- the forward end portion of the chamber 150 has an annular groove 153 formed therein for attachment of the needle assembly 140 .
- the needle assembly 140 includes a funnel-shaped needle support 143 .
- the wide end of the needle support 143 has an annular rib 145 that is snap-fit into groove 153 to faun a seal with the chamber 150 .
- the needle support 143 can be made of a resilient plastic material, or metal with a rubber seal that seats into groove 153 .
- the forward narrow end 147 (see FIG. 2A ) of the needle support 143 sealingly receives the rearward end of hollow needle 141 .
- the needle support 143 forms a sealed fluid channel from the chamber 150 to the needle 141 .
- a rubber needle sheath 202 surrounds the needle 141 and receives the narrow end 147 of the needle support 143 .
- a filter 190 is sealingly retained across the entire wide-end mouth of the needle support 143 by an annular sealing washer 156 . Alternatively, the filter 190 could be ultrasonically welded or otherwise secured to the needle support 143 .
- FIGS. 2B , 3 A, and 4 illustrate another embodiment of a needle assembly 140 and chamber 150 .
- the chamber 150 in this embodiment is known in the art as a dental cartridge.
- the dental cartridge has a cylindrical rear portion and a narrowed forward neck portion defining an outer annular groove 1 S 3 .
- the forward end of the dental cartridge defines an annular flange portion 154 .
- the needle support 143 has a rearward annular flange 155 that receives an annular sealing member 156 that surrounds both sides of flange 155 .
- the sealing member 156 serves to seal a filter 190 over the wide end of the funnel shaped needle support 143 .
- the rearward surface of the sealing member 156 is sealingly clamped against the forward surface of chamber flange 154 by a metal retaining damp 157 as best seen in FIG. 4 .
- forward end 1221 of the collet 122 extends into the rearward end of chamber 150 and is adapted to connect with a plunger 170 rearwardly sealing the wet container 151 .
- the plunger 170 is adapted to sealingly engage the side wall of the wet container 150 to prevent leakage of the contents (e.g., liquid injection solution) of the wet container 151 .
- the plunger 170 is preferably formed from a material having low factional properties such that the collet 122 and plunger 170 may easily slide within the wet container 150 when operated.
- the plunger 170 may be lubricated with silicone or other suitable non-reactive lubricant The movement of the collet 122 and the plunger 170 pressurizes the liquid located within the wet container 151 . A suitable medicament is located within a dry container 152 .
- FIGS. 1 and 2A is advantageous in that it has an open mouth configuration wherein the needle-end of the vial or chamber is not significantly narrowed or tapered.
- Such an open mouth configuration permits direct access to the dry portion 152 of chamber 150 for easy loading. Further, the open mouth configuration aids in preventing cross contamination between wet portion 151 and dry portion 152 in that the dry portion 152 does not have to be filled through liquid portion 151 of chamber 150 .
- Needle assembly 140 can be mounted to vial or chamber 150 in a snap-on configuration ( FIG. 3B ), an internal mount configuration ( FIG. 3C ), or an external needle assembly configuration ( FIG. 3D ).
- seal structure 160 is adapted to engage the interior side walls of chamber 150 to prevent passage of the contents (eg., liquid injection solution) of wet portion 151 into the dry portion 152 prior to activation of the automatic injection assembly.
- seal structure 160 can include an outer sealing member 180 , a movable sealing plug 166 , a by-pass zone 165 y at least one flow path 167 , and preferably also includes a filter or membrane 164 .
- seal structure 160 can preferably be formed as a six piece ( FIG. 5A ), five piece ( FIG. 5B ), four piece ( FIG. 5C ), or three piece ( FIG. 5D ) configuration.
- the outer sealing structure 180 of the six piece configuration can comprise a two piece annular rigid body 181 wherein members 181 a, 131 b thereof are formed into the two piece rigid body using, annular weld connections or other bonding techniques known in the art.
- Outer sealing structure 180 can further include multiple external sealing members 182 , e.g., two O-rings, to provide an annular sealing engagement with the inner wall of vial or compartment 150 .
- the sealing structure 180 further includes an internal plug member 166 and a filter or dispersion membrane 164 as will be discussed in greater detail later.
- outer sealing structure 180 can include a single external sealing member 182 , e.g., a unitary gasket, to provide an annular sealing engagement with the inner wall of vial or compartment 150 .
- External sealing member 182 may optionally be secured to two piece rigid body 181 using any bonding techniques known in the art.
- rigid body members 181 a, 181 b may be shaped such that they securingly engage external sealing members 182 within notched recesses 183 .
- sealing members 182 may be secured to rigid body members 181 a, 181 b by an interference fit.
- a filter or membrane 164 is clamped in place at the proximal end of flow path 167 between member 181 a and member 181 b of the two piece rigid body.
- outer sealing structure 180 comprises a unitary internal rigid member 181 and an external sealing member 182 .
- internal rigid member 181 and external sealing member 182 may optionally be secured together using any bonding techniques known in the art.
- internal rigid member 181 and external sealing member 182 may be formed such that they securingly engage each other using a combination of notched recesses 183 and extending shoulders 184 .
- the filter or membrane 164 can be held in place between internal rigid member 181 and shoulder 184 of external sealing member 182 .
- the filter 164 may be ultrasonically welded or otherwise secured to the rigid member 181 .
- outer sealing object 180 can comprise a unitary external sealing member 182 which can optionally be molded so as to accommodate filter or member 164 within retaining recess 185 .
- FIGS. 6A and 6B illustrate another embodiment that is very similar to that of FIG. 5A , but provides a slightly different shape for outer annular rigid body 181 and particularly the members 181 a, 181 b thereof.
- external sealing member 182 is preferably formed from a non-reactive elastomer material which can provide for the necessary sealing engagement with the inner wall of vial or compartment 150 . Further, external sealing member 182 can optionally be lubricated with silicon or other suitable non-reaction lubricant to facilitate movement of the outer sealing object 180 forwardly within vial or compartment 150 upon receiving sufficient force as will be described.
- the movable sealing plug 166 is preferably formed from a material, such as an elastomer or PTFE, having low factional properties such that the sealing plug 166 may easily slide within outer sealing object 180 when the injector is activated.
- the movable sealing plug 166 may also optionally be lubricated with silicon or other suitable non-reactive lubricant
- the outer annular structure 180 defines an inner surface having a smooth cylindrical configuration towards the rearward portion 169 thereof and longitudinally extending grooves 168 towards the forward portion thereof
- the grooves 168 create a flowpath or flowpaths 167 through which liquid in the wet compartment 151 can bypass seal plug 166 when the plug 166 is moved forwardly from sealing engagement with cylindrical surface portion 169 into the grooved portion 168 .
- the movement of the sealing plug 166 into the by-pass area 165 opens the fluid flow path 167 between wet portion 151 and dry portion 152 .
- the movable sealing plug 166 preferably includes a plurality of circumferential grooves 186 to provide for enhanced sealing engagement and to facilitate sliding action of the plug 166 .
- the seal structure 160 preferably includes filter or membrane 164 at the end of flow path 167 through which the liquid injection solution may pass after the injector has been activated.
- the liquid injection solution then enters the dry portion 152 of the chamber 150 where it mixes with and dissolves the dry medicament More particularly, the filter 164 disperses the liquid injection solution exiting the seal structure 160 to present laminar fluid flow to the full surface of the dry medicament, thereby wetting the entire surface of the dry medicament for rapid and complete dissolution.
- the filter membrane 164 can be any structure that generally uniformly distributes the liquid across the entire diameter of the chamber 150 for enhanced dissolution of the dry medicament.
- the plunger 170 then begins to travel forwardly through the chamber 150 .
- the increased pressure within the wet compartment 151 moves the sealing plug 166 from a first sealed position wherein sealing plug 166 is sealingly engaged with surface 169 of outer sealing structure 180 ( FIG. 6A ) to a second by-pass position ( FIG. 6B ) that allows the injection solution to flow through flow path 167 created by grooves 168 and thereby through seal structure 160 .
- the high pressure developed within the wet portion 151 in response to movement of the collet 122 and the plunger assembly 170 forces the liquid injection solution through the seal structure 160 dissolving the drug into a medicament injection solution which will then be forced out through the needle 141 and into the patient.
- the plunger 170 will eventually contact the seal structure 160 , which, in a preferred embodiment, causes the seal structure 160 to move in the direction of the needle assembly 140 . Movement of the seal structure 160 would cause any remaining solution within the portion 152 to be dispersed through the needle assembly 140 , so as to reduce the amount of residual medicament remaining within the chamber 150 .
- a membrane or filter 190 is preferably provided adjacent the needle assembly 140 to prevent any dry medicament particles from clogging the rearward end of needle 141 prior to an injection operation.
- the membrane 190 may also serve to slightly restrict or slow injection of medicament into the patient, to facilitate more thorough dissolution during injection.
- a medicament support 190 is preferably provided between the end of the dry compartment 152 and the needle assembly 140 .
- the support 190 can serve to prevent blockage of the needle assembly 141 by preventing the dry medicament from entering the area surrounding the needle assembly 140 while permitting passage of the mixture of dissolved medicament and liquid injection solution.
- the support 190 may be configured as described in U.S. Provisional Application No. 60/238,448, which is herein incorporated by reference in a manner consistent with this disclosure. It is contemplated that multiple supports 190 may be located within the dry compartment 152 . The provision of the supports 190 may also improve the laminar flow of the liquid injection solution through the dry medicament thereby improving dissolution.
- a diaphragm assembly (not shown) may also be provided adjacent the medicament support 190 , as known in the art.
- the diaphragm assembly acts to prevent the passage of the liquid injection solution to the needle assembly 140 prior to activation of the actuator assembly 120 . More particularly, the diaphragm assembly will not rupture until either the butt end of the needle assembly 140 ruptures the expanded diaphragm or sufficient pressure builds in the dry compartment 160 to rupture the diaphragm, again as known in the art.
- the movement of the collet 122 causes the injection needle 141 of the injection assembly 140 to advance and protrude through the housing 110 .
- the injection of the medicament can be performed with a simple operation.
- the user simply removes the end cap assembly 130 , locates the injection end of the housing 110 adjacent the injection site, and presses the push button 132 .
- This operation automatically triggers the operation of the drive assembly or spring 250 to advance the collet 122 causing the liquid injection solution located within the wet portion 151 to enter the dry portion 152 through the seal structure 160 .
- the dissolved medicament is then transmitted through the injection needle 141 to provide the user with the necessary dose of medicament.
- the automatic injector 10 in accordance with the present invention reduces the amount of time required to administer medicament compared to other wet/dry injectors and eliminates the need for mixing by the user.
- the seal structure 160 advantageously enables the manufacture of a superior wet/dry auto injector with a complementary combination of components that are either known in the art of conventional auto-injectors or are otherwise relatively simple to manufacture.
- the seal structure 160 enables sufficient mixing of wet and dry medicament components without requiring manual shaking.
- This mixing action is enhanced by the filter or membrane 164 .
- the filter 164 is a supported, hydrophobia acrylic copolymer cast on a non-woven nylon support Preferably, it is a FlouRepel treated membrane for superior oleoplhobicity/hydrophobicity.
- the automatic injector cartridge in another embodiment, shown in FIG. 7 , includes a needle assembly 140 located within the dry portion 152 .
- the needle assembly 140 extends within the dry portion 152 to the sealing structure 180 , described above in connection with FIGS. 5A-5D .
- the sealing structure 180 separates the dry portion 152 from the wet portion 151 .
- the cartridge further includes a plunger 170 positioned therein.
- the plunger 170 is configured to engage the collet 122 of the activation assembly 120 .
- the cartridge includes a sheath 301 .
- the sheath 301 maintains the needle 141 in a sterile environment until it projects from the end of the sheath 301 in response to activation of the activation assembly 120 .
- the needle assembly 140 passes through the dry portion 152 as the wet medicament passes through the sealing structure 180 .
- no inner plug 166 is provided.
- the outer structure 180 is simply complemented by a seal membrane 226 that extends across the inner area defined by the inner surface of the outer structure.
- pressurization of the wet compartment 151 causes the seal membrane 226 to rupture, thereby allowing the seal structure 160 to permit liquid to pass therethrough.
- the member 232 on which the pointed member 228 is mounted has a plurality of passages 234 that permits fluid to pass therethrough.
- Filter or membrane 164 is preferably mounted distal to the passages 234 to present laminar or distributed flow to the dry medicament.
- An injector according to the present invention was loaded with liquid injection solution and dry medicament and activated with the follow results.
- a cover assembly described for example in U.S. Pat. No. 5,295,965 (the disclosure of which is specifically incorporated herein by reference) may be secured to the injection end of the housing 110 after deployment of the medicament
- the automatic injector may further include a nipple plunger assembly, as described for example in U.S. Pat. No. 5,713,866 (the disclosure of which is specifically incorporated herein by reference).
- the forward dry chamber 152 contains the needle 141 , as shown in FIG. 7 .
- the needle 141 is forced through a forward plug stopper upon initial compression of the two chamber system.
- providing the needle 141 in the forward chamber 152 provides improved longitudinal compactness of the design.
- a pre-filled syringe is provided with the seal structure disposed between wet and dry components.
- the seal structure 160 can be used in the same type of injector described herein, except rather than employing a dry (powder) medicament separated by a liquid component, a first liquid medicament is separated from a second fluid component by the seal structure 160 .
- the seal structure 160 can be used in what is known in the art as a “needleless injector” where an injection can be made into a patient without a needle or cannula.
- FIG. 9 is a longitudinal cross-sectional view of a chamber 350 mounted to a needle assembly 340 according to a further embodiment of the invention. Neither a housing 110 nor an actuator assembly 120 is shown in FIG. 9 ; however, the chamber 350 and needle assembly 340 may be used with the housings 110 and actuator assemblies 120 described above or with substantially any known housing or actuator assembly.
- the chamber 350 has a wet portion or compartment 151 and a dry portion or compartment 152 .
- a sealing structure 360 separates the wet portion 151 and the dry portion 152 .
- the sealing structure 360 includes an outer sealing member 380 , a moveable sealing plug 166 , a by-pass zone 165 , and may also include a filter or dispersion membrane 164 .
- a moveable sealing plug 166 is shown in FIG. 9
- the sealing structure 360 may include a rupturable seal membrane 226 instead of a sealing plug 166 , as shown in FIGS. 8A and 8B .
- FIG. 10 is a perspective view of the outer sealing member 380 .
- FIG. 11 is a front elevational view of the sealing member 380
- FIG. 12 is a sectional view of the outer sealing member 380 taken through Line 12 - 12 of FIG. 11 .
- the outer sealing member 380 has an annular wiper portion 382 that makes sealing contact with the inner wall of the dry portion 152 of the chamber 350 and extends axially forwardly, in the direction of actuating movement along the longitudinal axis of the chamber 350 , toward the needle assembly 140 .
- the wiper portion 382 helps to eliminate the accumulation of powder around the sealing member 380 by “wiping” or “scraping” any accumulated powder away from the wall of the chamber 350 and directing it radially inwardly, where it can properly mix with the wet medicament portion as the sealing member 380 passes through the dry portion 132 .
- the wiper portion 382 makes contact with the inner wall of the dry portion 132 of the chamber 330 along substantially the entirety of its length. The extent of contact between the wiper portion 382 and the inner wall of the dry portion 152 is possible, at least in part, because the wiper portion 382 extends axially.
- a wiper portion 382 although shown in the embodiment of FIG. 9 , may be used in any of the embodiments shown and described above and in any variations thereof.
- the chamber 350 has an “open mouth” configuration; i.e., the container itself does not taper substantially as it meets the needle assembly 340 (for example, as compared with the embodiment shown in FIG. 3A ).
- the advantages of having an “open mouth” container were described above with respect to the container 150 . If the “mouth” of the container (i.e, the opening into the dry portion 152 of the container) is open and wide, it becomes easier to load the dry component of the medicament. However, having a tapered portion adjacent to the needle assembly 340 helps to direct the medicament radially inwardly, toward the needle assembly 340 , when the injection is taking place.
- the chamber 350 includes a tapered insert 384 at its mouth, just behind the needle assembly 340 .
- FIG. 13 is a perspective view of the tapered insert 384
- FIG. 14 is a front elevational view
- FIG. 15 is a sectional view through Line 15 - 15 of FIG. 14 .
- the tapered insert 384 tapers radially inwardly as it extends axially forwardly, such that it forms a funnel portion 386 with a small central opening 388 at one end.
- the tapered insert 384 also has a rearward open end 389 with a larger open diameter.
- the insert 384 sealingly engages the walls of the chamber 350 .
- Extending radially outward from the outer surface of the funnel portion 386 proximate to the small central opening 388 is an annular sealing flange 390 .
- the annular sealing flange 390 is an integral portion of the tapered insert 384 .
- the annular sealing flange 390 may be joined to the funnel portion 386 by adhesives or other securing methods. Additionally, as will be described in more detail below, in some configurations, the annular sealing flange 390 may be absent.
- the insert 384 is preferably formed from a material that will not react with the dry medicament stored in the compartment 152 .
- the chamber 350 and needle assembly 340 include a metallic skirt, generally indicated at 392 , that is rolled or crimped so as to capture or secure the needle assembly 340 to the front end of the chamber 330 .
- the annular sealing flange 390 fits between the chamber 350 and needle assembly 340 so as to form a seal between them.
- the entire tapered insert 384 may be made of an elastomeric or other rubber material suitable for sealing.
- the tapered insert 384 may be removed from the chamber 350 in order to effect the loading of the dry medicament and then inserted into the chamber 350 prior to joining with the needle assembly 340 .
- the tapered insert 384 is shown with a funnel portion 386 of constant, radially inward taper, the tapering of the tapered insert 384 may be of any type that will facilitate fluid flow from the chamber 350 into the needle assembly 340 .
- the small, central opening 388 in the insert 384 is covered by a filter 190 that is positioned between the tapered insert 384 and the needle support 343 to filter fluids passing from the chamber 350 into the needle assembly 340 , so as to prevent any undissolved medicament from entering the needle assembly 340 .
- a filter 190 Forward of the filter 190 , defined by the rearward (container-facing) side of the needle support 343 is a chamber 394 that tapers radially inwardly toward its forward end.
- the chamber 394 is contoured to expose a substantial portion of the surface area of the filter 190 to the flow between the chamber 350 and the needle assembly 340 .
- the chamber 394 has an opening at least as large as the small central opening 388 in the tapered insert 384 .
- the chamber 394 is substantially hemispherical, although other configurations may be used.
- the chamber 394 can be seen more clearly in FIG. 16 , which is a longitudinal cross-sectional view of a portion of the needle assembly 340 .
- the chamber 394 allows greater, more laminar, and more fully developed flow through the filter 190 to the needle 141 .
- the chamber 394 is shaped to direct the flow of medicament to the needle 141 .
- neither the needle 141 nor any other structure protrudes into the chamber 394 .
- a chamber 394 and needle assembly such that a portion of the end of the needle protruded into the chamber 394 , such an arrangement might cause turbulent flow around the end of the needle that protruded into the chamber 394 , or might otherwise eliminate some of the benefits of the chamber 394 .
- the sealing member 380 with wiper portion 382 , tapered insert 384 , and chamber 394 may all be used in a wet/wet autoinjector assembly that includes two fluid medicament components.
- a burstable membrane is typically positioned over the opening of the compartment adjacent to the needle assembly, in order to prevent fluid in that compartment from leaking out of the compartment and into the needle assembly.
- a burstable membrane may be provided as a portion of the tapered insert 384 .
- the burstable membrane could be positioned in the funnel portion 386 of the insert.
- the sealing member 380 , tapered insert 384 , and chamber 394 may also be used in a wet/dry or wet/wet autoinjector assembly that does not include all of the features described above.
- the tapered insert 384 and chamber 394 may be used in any wet/dry or wet/wet autoinjector in order to improve the loading and dispensing performance of the autoinjector.
- a chamber for an autoinjector may be filled with appropriate medicament components in several different ways.
- one common way to fill an autoinjector chamber is to fill a first medicament (e.g., a wet medicament) through an opening in the chamber and then fill a second medicament (e.g., a dry medicament) through that same opening in the chamber.
- a first medicament e.g., a wet medicament
- a second medicament e.g., a dry medicament
- any powder that accumulates around the opening may mix with a subsequently-filled wet medicament, thereby contaminating the contents of the wet compartment
- liquid that accumulates around the opening may mix with some of the subsequently-filled dry medicament, thereby contaminating the contents of the dry compartment.
- a chamber 150 , 350 it is advantageous to till the chamber 150 , 350 using a separate opening in the chamber 150 , 350 for each type of medicament, thus eliminating the cross-contamination problem.
- This sort of filling process for a chamber 150 , 350 includes a number of tasks and will be described below with respect to the chamber 350 , although the described process is, in general, equally applicable to the other embodiments described above. Ordinarily, the filling process would be performed in an aseptic environment.
- the chamber 350 is initially open at both ends and does not include any interior structures, as shown in FIG. 17A .
- a seal structure such as seal structure 360 , is first inserted into the chamber 350 so that it is positioned substantially as shown in FIG. 17B .
- the chamber 350 is removed to or placed in a low particulate aseptic environment, and is positioned so that the wet portion or compartment 151 can be filled through an opening 396 in the rear end of the chamber 350 , as shown in FIG. 17C .
- the low particulate environment prevents possible cross-contamination of the wet portion 151 .
- the opening 396 in the rear end of the chamber 350 is sealed by installing the plunger 170 , as shown in FIG. 17D .
- the placement of the chamber 350 in a low particulate environment prior to filling the wet portion 151 helps to prevent contamination of the wet portion 151 by powder or other participates.
- the chamber 350 is removed from the low participate environment and is placed in an appropriate aseptic environment so that the dry portion or chamber 152 of the chamber 350 can be filled through an opening 398 in the front of the chamber 350 .
- One way to fill the dry portion 152 is to place a dry powder directly into the dry portion 152 through the opening 398 , as shown in FIG. 17E .
- Another way to fill the dry portion 152 is to fill the dry portion 152 with a liquid medicament through the opening 398 and then lyophilize the liquid medicament directly in the dry portion 152 to leave only the desired dry medicament. While this process of liquid filling and lyophilizing may be used, it sometimes leaves residues in the dry portion 152 , which may interfere with the stability of the dry medicament or otherwise contaminate.
- a third way to fill the dry portion 152 is to lyophilize a liquid medicament in a separate container to form a lyophilized dry medicament tablet 400 and then deposit the dry medicament tablet 400 in the dry portion 152 through the opening 398 , as shown in FIG. 17F .
- This variation of the filling process is used most advantageously with a chamber that has a relatively wide opening into its dry portion, so that tablets of various sizes can be accommodated. If a chamber has a relatively narrow opening into its dry portion, it may be necessary to fill that dry portion with powder, or to lyophilize a liquid medicament directly in the dry portion to form a dry powder.
- a tapered insert 384 is placed in opening 398 of the chamber 350 and the needle assembly 340 is secured over the tapered insert 384 .
- the chamber 350 is as shown in FIG. 9 .
Abstract
An automatic injection device including a housing, a chamber with a first compartment and a second compartment, and a seal structure between the compartments. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, where the seal includes a plug and an outer sealing member. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment. The automatic injection device also includes a needle assembly and an activation assembly. Activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.
Description
- This application is a continuation of U.S. patent application Ser. No. 12/784,595, filed May 21, 2010, which is a continuation of U.S. patent application Ser. No 11/698,965, filed Jan. 26, 2007, now U.S. Pat. No. 7,749,190, which is a division of U.S. patent application Ser. No. 10/690,987, filed Oct. 23, 2003, now U.S. Pat. No. 7,621,887, which is a continuation-in-part of U.S. patent application Ser. No. 09/897,422, filed Jul. 3, 2001, now U.S. Pat. No. 6,641,561, and U.S. patent application Ser. No. 09/972,202, filed on Oct. 9, 2001, now U.S. Pat. No. 6,770,052, both of which claim priority to U.S. Provisional Applications Nos. 60/238,458, 60/238,448, and 60/238,447, all filed on Oct. 10, 2000. The contents of all these applications are incorporated by reference herein in their entireties.
- The invention relates to drug delivery devices. More particularly, the invention relates to automatic injector assemblies capable of mixing two components of a medicament and then delivering the mixed medicament to an injection site.
- An automatic injector is a device that enables intramuscular (IM) or subcutaneous administration of a dosage of medicament. Generally, the medicament is stored as a liquid formulation which is then injected intramuscularly. An advantage of automatic injectors is that they contain a measured dosage of a liquid medicament in a sealed sterile cartridge. As such automatic injectors allow for quick and simple IM injection of a liquid medicament in emergency situations without the need for measuring dosages. Another advantage of automatic injectors is that the administration of the medicament is accomplished without the user initially seeing the hypodermic needle through which the medicament is delivered, and without requiring the user to manually force the needle into the patient. This is particularly advantageous when the medicament is being self-administered.
- There are drawbacks associated with the long-term storage of medicament in a liquid formulation. For instance, some medicaments are not stable in solution and thus have a shorter shelf life than their solid counterparts. To address this concern, automatic injectors have been developed which store the medicament in solid form and mix the solid medicament with a liquid solution immediately prior to injection. These injectors, disclosed for example in US Reissue Pat. No. 35,986, entitled “Multiple Chamber Automatic Injector,” (the disclosure of which is incorporated herein specifically by reference), however, require the user of the injector to manually rupture a sealing member between the solid and liquid components and then manually shake the injector body to expedite dissolution of the solid component prior to injection. This increases the time needed to administer a dose of the medicament. However, rapid delivery of the medicament is needed in many emergency medical situations (e.g., nerve gas and chemical agent poisoning). Other wet/dry injection devices have been expensive to manufacture or provide unsatisfactory mixing of components prior to injection. Therefore, there is a need for a cost-effective automatic injector that stores medicament in solid form that does not require manual premixing by the user.
- One aspect of the invention relates to an automatic injection device for automatically administering a medicament upon actuation thereof, where the device includes a housing, a chamber disposed in the housing having a first compartment and a second compartment, and a seal structure between the first compartment and the second compartment. The seal structure is initially in a sealing condition that seals the first compartment from the second compartment, and includes a plug and an outer sealing member that forms a peripheral seal with an interior wall of the chamber. The plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment through the seal structure. The plug also maintains the same orientation with respect to the outer sealing member as the plug moves to convert the seal structure from the sealing condition to the mixing condition. The automatic injection device further includes a needle assembly connected to the first compartment, and an activation assembly carried by the housing. Activation of the activation assembly causes: (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.
- Another aspect of the invention relates to an automatic injection device containing a medicament for automatically administering the medicament upon actuation thereof where the device includes a housing, a chamber disposed in the housing having a first compartment and a second compartment, and a seal structure between the first compartment and the second compartment. The seal structure is initially in a sealed condition to maintain the first compartment separate from the second compartment, where the seal structure converts to a mixing condition in response to activation of the device. The seal structure includes an outer sealing member that forms a peripheral seal with an interior wall of the chamber, and a plug spaced radially inward from the outer sealing member. The plug is in a first position where it is sealingly engaged with a surface of the outer sealing member to form a liquid-tight seal between the first and second compartments when the seal structure is in the sealed condition. The plug is in a second position when the seal structure is in the mixing condition. The plug then remains stationary in the second position as the liquid component flows through the seal structure and thereafter. The automatic injection device further includes a needle assembly connected to the chamber and an activation assembly disposed in the housing. Activation of the activation assembly causes; (1) pressurization of the first compartment, (2) the seal structure to convert from the sealed condition to the mixing condition, and (3) contents of the first and second compartments to be mixed and forced through the needle assembly.
- These and other aspects and advantages of the invention will be described below.
- The invention will be described in conjunction with the following, drawing figures, in which like reference numerals designate like elements, and in which:
-
FIG. 1 is a longitudinal cross-sectional view of a wet/dry automatic injector assembly in accordance with an embodiment of the present invention; -
FIGS. 2A-2B illustrate longitudinal cross-sectional views of needle support assemblies in accordance with certain embodiments of the present invention; -
FIGS. 3A-3D illustrate cross-sectional side views of various cartridge or chamber configurations and corresponding needle assembly options according to certain embodiments of the present invention; -
FIG. 4 is an enlarged partial cross-sectional side view of a needle assembly/cartridge engagement according to another embodiment; -
FIGS. 5A-5D illustrate cross-sectional side views of various embodiments of a seal structure according to the present invention; -
FIG. 6A is a longitudinal cross-sectional side view of a seal structure in accordance with another embodiment of the present invention, wherein the movable sealing plug is in a closed sealing position blocking the flow of the liquid injection solution; -
FIG. 6B is a longitudinal cross sectional side view of seal structure similar to 6A, but showing the movable sealing plug in an open by-pass position permitting the flow of the liquid injection solution; -
FIG. 6C is a lateral cross sectional view of the seal structure of the present invention taken through theline 6C-6C inFIG. 6A ; -
FIG. 6D is a lateral cross sectional view of the seal structure of the present invention taken through theline 6D-6D inFIG. 6B ; -
FIG. 7 is a longitudinal cross-sectional view of a wet/dry automatic injector cartridge or chamber configuration in accordance with another embodiment of the present invention; -
FIGS. 8A and 8B are longitudinal cross sectional views of two additional embodiments of seal structures in accordance with the present invention; -
FIG. 9 is a longitudinal cross-sectional view of a chamber and needle assembly according to a further embodiment of the invention; -
FIG. 10 is a perspective view of an outer sealing member in the chamber and needle assembly ofFIG. 9 ; -
FIG. 11 is a front elevational view of the outer sealing member ofFIG. 10 ; -
FIG. 12 is a longitudinal sectional view of the outer sealing member ofFIG. 10 , taken through Line 12-12 ofFIG. 11 ; -
FIG. 13 is a perspective view of a tapered insert in the chamber and needle assembly ofFIG. 9 -
FIG. 14 is a front elevational view of the tapered insert ofFIG. 13 ; -
FIG. 15 is a longitudinal sectional view of the tapered insert in the chamber and needle assembly ofFIG. 13 , taken through Line 15-15 ofFIG. 14 ; -
FIG. 16 is a longitudinal sectional view of a portion of the needle assembly ofFIG. 9 , illustrating a chamber behind die needle assembly filter; and -
FIGS. 17A-17F are sectional and partially sectional views of a chamber illustrating a process for filling it with dry and liquid medicament components. - In the following description, the present invention is described in connection with a push button type auto injector, whereby the user removes an end cap assembly and presses a button to trigger the injection process. The present invention, however is not limited to push button type automatic injectors; rather, it is contemplated that the present invention may be incorporated into a nose activated auto injector, as described for example in U.S. Pat. No. 5,354,286, the disclosure of which is hereby incorporated herein by reference for such teaching.
-
FIG. 1 is a longitudinal cross-sectional view of anautomatic injector assembly 10 in accordance with an embodiment of the present invention. Theautomatic injector assembly 10 includes a generally hollow tubularplastic housing 110. Generally, thehousing 110 includes aninjection end 111 and anactivation end 112, as shown inFIG. 1 . In the embodiment shown, anactuator assembly 120 is inserted into the rearward end of thehousing 110. Theactuator assembly 120 is received within thehousing 110 untilflange 115 of asleeve member 144 is captured within anannular groove 117 on the interior surface ofhousing 110. Aremovable safety cap 130 is releasably secured to theactuator assembly 120. - The
actuator assembly 120 may be of any conventional type as known in the art, such as that disclosed in commonly assigned U.S. Pat. No. 5,391,151 hereby incorporated by reference. The present invention employs a rear-end activating device, similar to that in the aforementioned U.S. Pat. No. 5,391,151, and is therefore only briefly described herein. Theactuator assembly 120 includes anactivation button sleeve 132 having internal activation surfaces 134. The activation assembly further includes aplastic collet 122 with a split rearward portion formingspring fingers 136 as known in the art Thesafety cap 130 has apin portion 138 that extends between thespring fingers 136 so as to keep them spread apart when the injector is in a storage condition. Thespring fingers 136 terminate in semi-conical configurations including rearwardly facing slopingsurfaces 139 and forwardly facingflat surfaces 142. Thecollet 122 is surrounded by acylindrical sleeve 144 having inwardly extendingflange 146 at the rearward end thereof. Thecollet 122 has a forwardannular flange 148. Acoil spring 250 surrounds thecollet 122 and is compressed between theflange 148 andflange 146. The colletflat surfaces 142 are retained in engagement with the rearwardly facing surfaces of theflange 146, and thus prevented from moving off of the flange surfaces by thepin 138 when the injector is stored. - To activate the injector, the
safety pin 130 is manually pulled off of the rear end of the injector, thus removingpin 138 from between thefingers 136. Theactivation button 132 can then be pushed inwardly, and as a result of the activation surfaces thereof, 134 engages the slopingsurfaces 139 of thespring fingers 136. This forces thespring fingers 136 inwards toward one another and off of the retaining surfaces of theflange 146. Thecompressed spring 250 is then free to release the stored energy therein to move thecollet 122 forwardly under the force of the spring to affect an injection operation as will be described later in more detail. - The
actuator assembly 120 may be of any type known in the automatic injector art that employs releasable stored energy. For example, rather than employing a spring, it may employ a charge of compressed gas. - Located within the interior of the
housing 110 is a vial orchamber 150, preferably made of glass, for containing both a liquid injection solution and a dry medicament, or other types of medicament portions, as appropriate. Thechamber 150 is preferably a hollow cylinder, with a smooth cylindrical inner surface. The liquid injection solution is located within a wet portion orcompartment 151 of thechamber 150. The dry medicament is located within adry portion 152 or compartment of thechamber 150. It is contemplated that the dry medicament may be in powder, freeze-dried, or any other solid formulation known in the artA seal structure 160 engages the interior side walls of thechamber 150 to seal thedry portion 152 from thewet portion 151 and to prevent seepage of the liquid injection solution into thedry portion 152 prior to activation of the injector assembly. Further, aneedle assembly 140 mounts to the forward end of vial orchamber 150 to inject the medicament upon activation of the injector assembly. In this embodiment, the forward end portion of thechamber 150 has anannular groove 153 formed therein for attachment of theneedle assembly 140. Theneedle assembly 140 includes a funnel-shapedneedle support 143. The wide end of theneedle support 143 has anannular rib 145 that is snap-fit intogroove 153 to faun a seal with thechamber 150. Theneedle support 143 can be made of a resilient plastic material, or metal with a rubber seal that seats intogroove 153. The forward narrow end 147 (seeFIG. 2A ) of theneedle support 143 sealingly receives the rearward end ofhollow needle 141. Theneedle support 143 forms a sealed fluid channel from thechamber 150 to theneedle 141. Arubber needle sheath 202 surrounds theneedle 141 and receives thenarrow end 147 of theneedle support 143. Afilter 190 is sealingly retained across the entire wide-end mouth of theneedle support 143 by anannular sealing washer 156. Alternatively, thefilter 190 could be ultrasonically welded or otherwise secured to theneedle support 143. -
FIGS. 2B , 3A, and 4 illustrate another embodiment of aneedle assembly 140 andchamber 150. Thechamber 150 in this embodiment is known in the art as a dental cartridge. The dental cartridge has a cylindrical rear portion and a narrowed forward neck portion defining an outer annular groove 1 S3. The forward end of the dental cartridge defines anannular flange portion 154. In this embodiment, theneedle support 143 has a rearwardannular flange 155 that receives anannular sealing member 156 that surrounds both sides offlange 155. The sealingmember 156 serves to seal afilter 190 over the wide end of the funnel shapedneedle support 143. The rearward surface of the sealingmember 156 is sealingly clamped against the forward surface ofchamber flange 154 by a metal retaining damp 157 as best seen inFIG. 4 . - As shown in
FIG. 1 ,forward end 1221 of thecollet 122 extends into the rearward end ofchamber 150 and is adapted to connect with aplunger 170 rearwardly sealing thewet container 151. Theplunger 170 is adapted to sealingly engage the side wall of thewet container 150 to prevent leakage of the contents (e.g., liquid injection solution) of thewet container 151. Theplunger 170 is preferably formed from a material having low factional properties such that thecollet 122 andplunger 170 may easily slide within thewet container 150 when operated. Alternatively, theplunger 170 may be lubricated with silicone or other suitable non-reactive lubricant The movement of thecollet 122 and theplunger 170 pressurizes the liquid located within thewet container 151. A suitable medicament is located within adry container 152. - The embodiment of
FIGS. 1 and 2A is advantageous in that it has an open mouth configuration wherein the needle-end of the vial or chamber is not significantly narrowed or tapered. Such an open mouth configuration permits direct access to thedry portion 152 ofchamber 150 for easy loading. Further, the open mouth configuration aids in preventing cross contamination betweenwet portion 151 anddry portion 152 in that thedry portion 152 does not have to be filled throughliquid portion 151 ofchamber 150.Needle assembly 140 can be mounted to vial orchamber 150 in a snap-on configuration (FIG. 3B ), an internal mount configuration (FIG. 3C ), or an external needle assembly configuration (FIG. 3D ). - As mentioned above, the
seal structure 160 is adapted to engage the interior side walls ofchamber 150 to prevent passage of the contents (eg., liquid injection solution) ofwet portion 151 into thedry portion 152 prior to activation of the automatic injection assembly. Generally,seal structure 160 can include anouter sealing member 180, amovable sealing plug 166, a by-pass zone 165 y at least oneflow path 167, and preferably also includes a filter ormembrane 164. With reference toFIG. 5A-D ,seal structure 160 can preferably be formed as a six piece (FIG. 5A ), five piece (FIG. 5B ), four piece (FIG. 5C ), or three piece (FIG. 5D ) configuration. - More particularly, with reference to
FIG. 5A , theouter sealing structure 180 of the six piece configuration can comprise a two piece annularrigid body 181 whereinmembers 181 a, 131 b thereof are formed into the two piece rigid body using, annular weld connections or other bonding techniques known in the art.Outer sealing structure 180 can further include multipleexternal sealing members 182, e.g., two O-rings, to provide an annular sealing engagement with the inner wall of vial orcompartment 150. The sealingstructure 180 further includes aninternal plug member 166 and a filter ordispersion membrane 164 as will be discussed in greater detail later. - In another embodiment, as shown in
FIG. 5B , rather than plural O-rings,outer sealing structure 180 can include a singleexternal sealing member 182, e.g., a unitary gasket, to provide an annular sealing engagement with the inner wall of vial orcompartment 150. External sealingmember 182 may optionally be secured to two piecerigid body 181 using any bonding techniques known in the art. Further,rigid body members external sealing members 182 within notched recesses 183. Alternately, sealingmembers 182 may be secured torigid body members membrane 164 is clamped in place at the proximal end offlow path 167 betweenmember 181 a andmember 181 b of the two piece rigid body. - In another embodiment, as shown in
FIG. 5C ,outer sealing structure 180 comprises a unitary internalrigid member 181 and anexternal sealing member 182. Again, internalrigid member 181 andexternal sealing member 182 may optionally be secured together using any bonding techniques known in the art. Further, internalrigid member 181 andexternal sealing member 182 may be formed such that they securingly engage each other using a combination of notchedrecesses 183 and extendingshoulders 184. The filter ormembrane 164 can be held in place between internalrigid member 181 andshoulder 184 ofexternal sealing member 182. Alternatively, thefilter 164 may be ultrasonically welded or otherwise secured to therigid member 181. In yet another embodiment, as shown inFIG. 5D ,outer sealing object 180 can comprise a unitaryexternal sealing member 182 which can optionally be molded so as to accommodate filter ormember 164 within retainingrecess 185.FIGS. 6A and 6B illustrate another embodiment that is very similar to that ofFIG. 5A , but provides a slightly different shape for outer annularrigid body 181 and particularly themembers - In each embodiment illustrated in
FIGS. 5A-5D and 6A-6B, external sealingmember 182 is preferably formed from a non-reactive elastomer material which can provide for the necessary sealing engagement with the inner wall of vial orcompartment 150. Further, external sealingmember 182 can optionally be lubricated with silicon or other suitable non-reaction lubricant to facilitate movement of theouter sealing object 180 forwardly within vial orcompartment 150 upon receiving sufficient force as will be described. Themovable sealing plug 166 is preferably formed from a material, such as an elastomer or PTFE, having low factional properties such that the sealingplug 166 may easily slide withinouter sealing object 180 when the injector is activated. Themovable sealing plug 166 may also optionally be lubricated with silicon or other suitable non-reactive lubricant In the embodiments illustrated, and as specifically shown inFIG. 6B , it is preferred that the outerannular structure 180 defines an inner surface having a smooth cylindrical configuration towards therearward portion 169 thereof and longitudinally extendinggrooves 168 towards the forward portion thereof Thegrooves 168 create a flowpath orflowpaths 167 through which liquid in thewet compartment 151 can bypassseal plug 166 when theplug 166 is moved forwardly from sealing engagement withcylindrical surface portion 169 into thegrooved portion 168. The movement of the sealingplug 166 into the by-pass area 165 opens thefluid flow path 167 betweenwet portion 151 anddry portion 152. Themovable sealing plug 166 preferably includes a plurality ofcircumferential grooves 186 to provide for enhanced sealing engagement and to facilitate sliding action of theplug 166. - As mentioned above, the
seal structure 160 preferably includes filter ormembrane 164 at the end offlow path 167 through which the liquid injection solution may pass after the injector has been activated. The liquid injection solution then enters thedry portion 152 of thechamber 150 where it mixes with and dissolves the dry medicament More particularly, thefilter 164 disperses the liquid injection solution exiting theseal structure 160 to present laminar fluid flow to the full surface of the dry medicament, thereby wetting the entire surface of the dry medicament for rapid and complete dissolution. Thefilter membrane 164 can be any structure that generally uniformly distributes the liquid across the entire diameter of thechamber 150 for enhanced dissolution of the dry medicament. - During operation, manual activation of the
actuator assembly 120 releases the collet 122 (as described above), which applies pressure on theplunger assembly 170. The application of pressure on theplunger assembly 170 by the collet and spring assembly 124 moves theplunger 170 in the direction of theneedle assembly 140. As a result, theentire chamber 150 andneedle assembly 140 are moved forwardly in thehousing 110 such thatneedle 141 pierces through the front end ofsheath 202 and exits through the forward end of thehousing 110, and particularly through ahole 204 in the front nose-cone portion 206 of the housing. Thesheath 202, which serves to maintain theneedle 141 sterile when the injector is in storage, also serves as a shock absorber during activation as it is compressed in generally accordion like fashion between thenose cone 206 andneedle support 143. - When the
needle 141 is extended from thehousing 110 and thechamber 150 andneedle support 143 approach thenose cone 206 portion of the housing so that another forward movement ofchamber 150 is substantially resisted, theplunger 170 then begins to travel forwardly through thechamber 150. This pressurizes the liquid injection solution located within thewet compartment 151. With reference toFIG. 6A-6B , the increased pressure within thewet compartment 151 moves the sealingplug 166 from a first sealed position wherein sealingplug 166 is sealingly engaged withsurface 169 of outer sealing structure 180 (FIG. 6A ) to a second by-pass position (FIG. 6B ) that allows the injection solution to flow throughflow path 167 created bygrooves 168 and thereby throughseal structure 160. - As described above, the high pressure developed within the
wet portion 151 in response to movement of thecollet 122 and theplunger assembly 170 forces the liquid injection solution through theseal structure 160 dissolving the drug into a medicament injection solution which will then be forced out through theneedle 141 and into the patient. As thecollet 122 andplunger assembly 170 continue forward, theplunger 170 will eventually contact theseal structure 160, which, in a preferred embodiment, causes theseal structure 160 to move in the direction of theneedle assembly 140. Movement of theseal structure 160 would cause any remaining solution within theportion 152 to be dispersed through theneedle assembly 140, so as to reduce the amount of residual medicament remaining within thechamber 150. - As shown in
FIGS. 2A , 2B and 4, a membrane orfilter 190 is preferably provided adjacent theneedle assembly 140 to prevent any dry medicament particles from clogging the rearward end ofneedle 141 prior to an injection operation. Themembrane 190 may also serve to slightly restrict or slow injection of medicament into the patient, to facilitate more thorough dissolution during injection. - More particularly, to prevent the passage of undissolved dry medicament to the
needle assembly 140, amedicament support 190 is preferably provided between the end of thedry compartment 152 and theneedle assembly 140. Thesupport 190 can serve to prevent blockage of theneedle assembly 141 by preventing the dry medicament from entering the area surrounding theneedle assembly 140 while permitting passage of the mixture of dissolved medicament and liquid injection solution. Thesupport 190 may be configured as described in U.S. Provisional Application No. 60/238,448, which is herein incorporated by reference in a manner consistent with this disclosure. It is contemplated thatmultiple supports 190 may be located within thedry compartment 152. The provision of thesupports 190 may also improve the laminar flow of the liquid injection solution through the dry medicament thereby improving dissolution. - Further, a diaphragm assembly (not shown) may also be provided adjacent the
medicament support 190, as known in the art. The diaphragm assembly acts to prevent the passage of the liquid injection solution to theneedle assembly 140 prior to activation of theactuator assembly 120. More particularly, the diaphragm assembly will not rupture until either the butt end of theneedle assembly 140 ruptures the expanded diaphragm or sufficient pressure builds in thedry compartment 160 to rupture the diaphragm, again as known in the art. - As described above, the movement of the
collet 122 causes theinjection needle 141 of theinjection assembly 140 to advance and protrude through thehousing 110. As such, the injection of the medicament can be performed with a simple operation. In sum, the user simply removes theend cap assembly 130, locates the injection end of thehousing 110 adjacent the injection site, and presses thepush button 132. This operation automatically triggers the operation of the drive assembly orspring 250 to advance thecollet 122 causing the liquid injection solution located within thewet portion 151 to enter thedry portion 152 through theseal structure 160. The dissolved medicament is then transmitted through theinjection needle 141 to provide the user with the necessary dose of medicament. Theautomatic injector 10 in accordance with the present invention reduces the amount of time required to administer medicament compared to other wet/dry injectors and eliminates the need for mixing by the user. - The
seal structure 160 advantageously enables the manufacture of a superior wet/dry auto injector with a complementary combination of components that are either known in the art of conventional auto-injectors or are otherwise relatively simple to manufacture. Theseal structure 160 enables sufficient mixing of wet and dry medicament components without requiring manual shaking. This mixing action is enhanced by the filter ormembrane 164. In a preferred embodiment, thefilter 164 is a supported, hydrophobia acrylic copolymer cast on a non-woven nylon support Preferably, it is a FlouRepel treated membrane for superior oleoplhobicity/hydrophobicity. - In another embodiment, shown in
FIG. 7 , the automatic injector cartridge includes aneedle assembly 140 located within thedry portion 152. Theneedle assembly 140 extends within thedry portion 152 to the sealingstructure 180, described above in connection withFIGS. 5A-5D . The sealingstructure 180 separates thedry portion 152 from thewet portion 151. As shown inFIG. 7 , the cartridge further includes aplunger 170 positioned therein. Theplunger 170 is configured to engage thecollet 122 of theactivation assembly 120. The cartridge includes asheath 301. Like thesheath 202, thesheath 301 maintains theneedle 141 in a sterile environment until it projects from the end of thesheath 301 in response to activation of theactivation assembly 120. During operation, theneedle assembly 140 passes through thedry portion 152 as the wet medicament passes through the sealingstructure 180. - In other embodiments (see
FIGS. 8A and 8B ), noinner plug 166 is provided. Rather, theouter structure 180 is simply complemented by aseal membrane 226 that extends across the inner area defined by the inner surface of the outer structure. When thechamber 150 reaches the forward end of the housing during an injection operation, pressurization of thewet compartment 151 causes theseal membrane 226 to rupture, thereby allowing theseal structure 160 to permit liquid to pass therethrough. In this embodiment, it may be desirable to provide theseal structure 160 with apointed member 228 disposed adjacent to theseal membrane 226 to facilitate rupturing of the seal membrane upon pressurized expansion thereof during an injection operation. Themember 232 on which the pointedmember 228 is mounted has a plurality ofpassages 234 that permits fluid to pass therethrough. Filter ormembrane 164 is preferably mounted distal to thepassages 234 to present laminar or distributed flow to the dry medicament. - An injector according to the present invention was loaded with liquid injection solution and dry medicament and activated with the follow results.
-
Loaded Dispensed Operational Dry Powder Fluid Dry Powder Fluid Time Mg Ml % mg ml Secs. 531 2.7 94 497 2.3 4.0 557 2.7 93 515 2.3 4.5 582 2.6 92 537 2.2 4.4 - Other embodiments and modifications of the invention are also contemplated For example, a cover assembly, described for example in U.S. Pat. No. 5,295,965 (the disclosure of which is specifically incorporated herein by reference) may be secured to the injection end of the
housing 110 after deployment of the medicament Furthermore, the automatic injector may further include a nipple plunger assembly, as described for example in U.S. Pat. No. 5,713,866 (the disclosure of which is specifically incorporated herein by reference). - In yet a further embodiment, the forward
dry chamber 152 contains theneedle 141, as shown inFIG. 7 . Theneedle 141 is forced through a forward plug stopper upon initial compression of the two chamber system. As known in the art, providing theneedle 141 in theforward chamber 152 provides improved longitudinal compactness of the design. - In yet another embodiment, a pre-filled syringe is provided with the seal structure disposed between wet and dry components.
- In further contemplated embodiments, the
seal structure 160 can be used in the same type of injector described herein, except rather than employing a dry (powder) medicament separated by a liquid component, a first liquid medicament is separated from a second fluid component by theseal structure 160. In yet another embodiment, theseal structure 160 can be used in what is known in the art as a “needleless injector” where an injection can be made into a patient without a needle or cannula. -
FIG. 9 is a longitudinal cross-sectional view of achamber 350 mounted to aneedle assembly 340 according to a further embodiment of the invention. Neither ahousing 110 nor anactuator assembly 120 is shown inFIG. 9 ; however, thechamber 350 andneedle assembly 340 may be used with thehousings 110 andactuator assemblies 120 described above or with substantially any known housing or actuator assembly. - In the
chamber 350 andneedle assembly 340 shown inFIG. 9 , many of the components are the same as those described above with respect toFIG. 1 ; therefore, the description above will suffice for those components. - Like the
chamber 150, thechamber 350 has a wet portion orcompartment 151 and a dry portion orcompartment 152. A sealingstructure 360 separates thewet portion 151 and thedry portion 152. The sealingstructure 360 includes anouter sealing member 380, amoveable sealing plug 166, a by-pass zone 165, and may also include a filter ordispersion membrane 164. Although amoveable sealing plug 166 is shown inFIG. 9 , the sealingstructure 360 may include arupturable seal membrane 226 instead of a sealingplug 166, as shown inFIGS. 8A and 8B . -
FIG. 10 is a perspective view of the outer sealingmember 380.FIG. 11 is a front elevational view of the sealingmember 380, andFIG. 12 is a sectional view of the outer sealingmember 380 taken through Line 12-12 ofFIG. 11 . As shown, the outer sealingmember 380 has anannular wiper portion 382 that makes sealing contact with the inner wall of thedry portion 152 of thechamber 350 and extends axially forwardly, in the direction of actuating movement along the longitudinal axis of thechamber 350, toward theneedle assembly 140. - While the
outer sealing members 130 that were described above do form a seal with the inner wall of thecontainer 150, during the actuation process, powder from the dry medicament in thedry portion 152 tends to accumulate around the sealingmember member member 180. The entire area around and between the sealingmember 180 and the inner wall of thecontainer 150 can become a “dead space,” in which accumulated powder cannot properly mix with fluid. - The
wiper portion 382 helps to eliminate the accumulation of powder around the sealingmember 380 by “wiping” or “scraping” any accumulated powder away from the wall of thechamber 350 and directing it radially inwardly, where it can properly mix with the wet medicament portion as the sealingmember 380 passes through thedry portion 132. As shown inFIG. 9 , thewiper portion 382 makes contact with the inner wall of thedry portion 132 of the chamber 330 along substantially the entirety of its length. The extent of contact between thewiper portion 382 and the inner wall of thedry portion 152 is possible, at least in part, because thewiper portion 382 extends axially. Although it would be possible to construct a wiping structure that extended radially or angularly outward from the main body of the sealingmember 380, such a wiping structure would not be in contact with the inner wall of thedry portion 152 over substantially the entirety of its length. Therefore, it would be possible for such a putative wiping structure to cause an undesirable accumulation of medicament powder, particularly if medicament powder were to move past it and into the space between it and the inner wall of thedry portion 152. Accordingly, the straight, forwardly-extendingwiper portion 382 is currently preferred. - A
wiper portion 382, although shown in the embodiment ofFIG. 9 , may be used in any of the embodiments shown and described above and in any variations thereof. - As shown in
FIG. 9 , thechamber 350 has an “open mouth” configuration; i.e., the container itself does not taper substantially as it meets the needle assembly 340 (for example, as compared with the embodiment shown inFIG. 3A ). The advantages of having an “open mouth” container were described above with respect to thecontainer 150. If the “mouth” of the container (i.e, the opening into thedry portion 152 of the container) is open and wide, it becomes easier to load the dry component of the medicament. However, having a tapered portion adjacent to theneedle assembly 340 helps to direct the medicament radially inwardly, toward theneedle assembly 340, when the injection is taking place. - In order to realize the advantages of an “open mouth” container and the advantages of a tapered container, the
chamber 350 includes a taperedinsert 384 at its mouth, just behind theneedle assembly 340.FIG. 13 is a perspective view of the taperedinsert 384,FIG. 14 is a front elevational view, andFIG. 15 is a sectional view through Line 15-15 ofFIG. 14 . - The
tapered insert 384 tapers radially inwardly as it extends axially forwardly, such that it forms afunnel portion 386 with a smallcentral opening 388 at one end. Thetapered insert 384 also has a rearwardopen end 389 with a larger open diameter. Theinsert 384 sealingly engages the walls of thechamber 350. Extending radially outward from the outer surface of thefunnel portion 386 proximate to the smallcentral opening 388 is anannular sealing flange 390. In the embodiment shown inFIGS. 13-15 , theannular sealing flange 390 is an integral portion of the taperedinsert 384. However, in some embodiments, theannular sealing flange 390 may be joined to thefunnel portion 386 by adhesives or other securing methods. Additionally, as will be described in more detail below, in some configurations, theannular sealing flange 390 may be absent. Theinsert 384 is preferably formed from a material that will not react with the dry medicament stored in thecompartment 152. - The
chamber 350 andneedle assembly 340 include a metallic skirt, generally indicated at 392, that is rolled or crimped so as to capture or secure theneedle assembly 340 to the front end of the chamber 330. In this embodiment, theannular sealing flange 390 fits between thechamber 350 andneedle assembly 340 so as to form a seal between them. Either theannular sealing flange 390 itself or, depending on the configuration, the entiretapered insert 384 may be made of an elastomeric or other rubber material suitable for sealing. - The
tapered insert 384 may be removed from thechamber 350 in order to effect the loading of the dry medicament and then inserted into thechamber 350 prior to joining with theneedle assembly 340. Although the taperedinsert 384 is shown with afunnel portion 386 of constant, radially inward taper, the tapering of the taperedinsert 384 may be of any type that will facilitate fluid flow from thechamber 350 into theneedle assembly 340. - At the forward end of the tapered
insert 384, the small,central opening 388 in theinsert 384 is covered by afilter 190 that is positioned between thetapered insert 384 and theneedle support 343 to filter fluids passing from thechamber 350 into theneedle assembly 340, so as to prevent any undissolved medicament from entering theneedle assembly 340. Forward of thefilter 190, defined by the rearward (container-facing) side of theneedle support 343 is achamber 394 that tapers radially inwardly toward its forward end. Thechamber 394 is contoured to expose a substantial portion of the surface area of thefilter 190 to the flow between thechamber 350 and theneedle assembly 340. Preferably, thechamber 394 has an opening at least as large as the smallcentral opening 388 in the taperedinsert 384. In the embodiment shown inFIG. 9 , thechamber 394 is substantially hemispherical, although other configurations may be used. Thechamber 394 can be seen more clearly inFIG. 16 , which is a longitudinal cross-sectional view of a portion of theneedle assembly 340. Thechamber 394 allows greater, more laminar, and more fully developed flow through thefilter 190 to theneedle 141. Furthermore, thechamber 394 is shaped to direct the flow of medicament to theneedle 141. - As is also shown in
FIG. 16 , neither theneedle 141 nor any other structure protrudes into thechamber 394. Although it would be possible to construct achamber 394 and needle assembly such that a portion of the end of the needle protruded into thechamber 394, such an arrangement might cause turbulent flow around the end of the needle that protruded into thechamber 394, or might otherwise eliminate some of the benefits of thechamber 394. - The sealing
member 380 withwiper portion 382, taperedinsert 384, andchamber 394 may all be used in a wet/wet autoinjector assembly that includes two fluid medicament components. In a wet/wet autoinjector assembly, a burstable membrane is typically positioned over the opening of the compartment adjacent to the needle assembly, in order to prevent fluid in that compartment from leaking out of the compartment and into the needle assembly. If the sealingmember 380, taperedinsert 384, andchamber 394 are provided in a wet/wet autoinjector assembly, a burstable membrane may be provided as a portion of the taperedinsert 384. For example, the burstable membrane could be positioned in thefunnel portion 386 of the insert. - The sealing
member 380, taperedinsert 384, andchamber 394 may also be used in a wet/dry or wet/wet autoinjector assembly that does not include all of the features described above. For example, the taperedinsert 384 andchamber 394 may be used in any wet/dry or wet/wet autoinjector in order to improve the loading and dispensing performance of the autoinjector. - A chamber for an autoinjector may be filled with appropriate medicament components in several different ways. For example, one common way to fill an autoinjector chamber is to fill a first medicament (e.g., a wet medicament) through an opening in the chamber and then fill a second medicament (e.g., a dry medicament) through that same opening in the chamber. This process, while common, tends to cause cross-contamination because both wet and dry medicaments are filled through the same opening. For example, if a dry powder medicament is filled first, any powder that accumulates around the opening may mix with a subsequently-filled wet medicament, thereby contaminating the contents of the wet compartment Conversely, if the wet medicament is filled first, liquid that accumulates around the opening may mix with some of the subsequently-filled dry medicament, thereby contaminating the contents of the dry compartment.
- However, using a
chamber chamber chamber chamber chamber 350, although the described process is, in general, equally applicable to the other embodiments described above. Ordinarily, the filling process would be performed in an aseptic environment. - Typically, the
chamber 350 is initially open at both ends and does not include any interior structures, as shown inFIG. 17A . A seal structure, such asseal structure 360, is first inserted into thechamber 350 so that it is positioned substantially as shown inFIG. 17B . - Once the
seal structure 360 is in place, thechamber 350 is removed to or placed in a low particulate aseptic environment, and is positioned so that the wet portion orcompartment 151 can be filled through anopening 396 in the rear end of thechamber 350, as shown inFIG. 17C . (The low particulate environment prevents possible cross-contamination of thewet portion 151.) After thewet portion 151 is filled, theopening 396 in the rear end of thechamber 350 is sealed by installing theplunger 170, as shown inFIG. 17D . The placement of thechamber 350 in a low particulate environment prior to filling thewet portion 151 helps to prevent contamination of thewet portion 151 by powder or other participates. - Once the
wet portion 151 is filled with the desired liquid medicament portion and the rear end is sealed with theplunger 170, thechamber 350 is removed from the low participate environment and is placed in an appropriate aseptic environment so that the dry portion orchamber 152 of thechamber 350 can be filled through anopening 398 in the front of thechamber 350. There are two common ways of filling thedry portion 152. One way to fill thedry portion 152 is to place a dry powder directly into thedry portion 152 through theopening 398, as shown inFIG. 17E . - Another way to fill the
dry portion 152 is to fill thedry portion 152 with a liquid medicament through theopening 398 and then lyophilize the liquid medicament directly in thedry portion 152 to leave only the desired dry medicament. While this process of liquid filling and lyophilizing may be used, it sometimes leaves residues in thedry portion 152, which may interfere with the stability of the dry medicament or otherwise contaminate. - A third way to fill the
dry portion 152 is to lyophilize a liquid medicament in a separate container to form a lyophilizeddry medicament tablet 400 and then deposit thedry medicament tablet 400 in thedry portion 152 through theopening 398, as shown inFIG. 17F . This variation of the filling process is used most advantageously with a chamber that has a relatively wide opening into its dry portion, so that tablets of various sizes can be accommodated. If a chamber has a relatively narrow opening into its dry portion, it may be necessary to fill that dry portion with powder, or to lyophilize a liquid medicament directly in the dry portion to form a dry powder. - After the
dry portion 152 is filled, atapered insert 384 is placed in opening 398 of thechamber 350 and theneedle assembly 340 is secured over the taperedinsert 384. When the process is complete, thechamber 350 is as shown inFIG. 9 . - Although the present invention has been described with respect to a number of embodiments, those embodiments are meant to be illustrative, rather than limiting. As those of ordinary skill in the art will understand, modifications and variations are possible within the scope of the appended claims.
Claims (20)
1. An automatic injection device for automatically administering a medicament upon actuation thereof, the device comprising:
a housing;
a chamber disposed in the housing and having a first compartment and a second compartment;
a seal structure between the first compartment and the second compartment, the seal structure initially in a sealing condition that seals the first compartment from the second compartment, the seal structure comprising a plug and an outer sealing member that forms a peripheral seal with an interior wall of the chamber, wherein the plug is slidably movable within the outer sealing member to convert the seal structure from the sealing condition to a mixing condition by opening a path between the first compartment and the second compartment through the seal structure, the plug maintaining the same orientation with respect to the outer sealing member as the plug moves to convert the seal structure from the sealing condition to the mixing condition;
a needle assembly connected to the first compartment; and
an activation assembly carried by the housing, wherein activation of the activation assembly causes (1) pressurization of the first compartment, (2) the seal structure to convert from the sealing condition to the mixing condition, and (3) the first and second medicament components to be mixed and forced through the needle assembly.
2. The automatic injection device of claim 1 , wherein activation of the activation assembly also causes the plunger to contact and move the seal structure through the first compartment toward the needle assembly.
3. The automatic injection device of claim 1 , further comprising a plunger that rearwardly seals the second compartment.
4. The automatic injection device of claim 1 , wherein the seal structure further comprises a fluid distributing member that creates a laminar fluid flow into the first compartment from the second compartment after the automatic injection device has been activated causing pressurization of the first compartment.
5. The automatic injection device of claim 1 , wherein the seal structure further comprises an annular wiper portion disposed at a front end of the seal structure and extends axially, the wiper portion positioned to engage an interior wall of the first compartment and configured to direct dry medicament particles engaged with the interior wall radially inward as the seal structure moves through the first compartment.
6. The automatic injection device of claim 5 , wherein the wiper portion comprises a peripheral lip having an inner surface that extends radially inward as it extends axially rearward.
7. The automatic injection device of claim 1 , further comprising an insert mounted in a front end of the chamber adjacent the needle assembly, the insert defining a tapering flow pathway that tapers radially inwardly as it extends axially forward.
8. The automatic injection device of claim 7 , wherein the needle assembly comprises a needle support for mounting the needle assembly to the front end of the chamber, the needle support defining a needle assembly chamber having an enlarged rearward end opening of a size that is at least as large as a front end opening of the insert.
9. The automatic injection device of claim 7 , further comprising a filter positioned between the needle assembly and the insert.
10. The automatic injection device of claim 1 , wherein the first compartment comprises a dry medicament component and the second compartment comprises a liquid medicament component.
11. An automatic injection device containing a medicament for automatically administering the medicament upon actuation thereof, the device comprising:
a housing;
a chamber disposed in the housing and having a first compartment and a second compartment;
a seal structure between the first compartment and the second compartment, the seal structure initially in a sealed condition to maintain the first compartment separate from the second compartment the seal structure converting to a mixing condition in response to activation of the device, the seal structure including:
an outer sealing member that forms a peripheral seal with an interior wall of the chamber, and
a plug spaced radially inward from the outer sealing member, the plug in a first position wherein the plug is sealingly engaged with a surface of the outer sealing member to form a liquid-tight seal between the first and second compartments when the seal structure is in the sealed condition, the plug in a second position when the seal structure is in the mixing condition, the plug remaining stationary in the second position as the liquid component flows through the seal structure and thereafter;
a needle assembly connected to the chamber; and
an activation assembly disposed in the housing wherein activation of the activation assembly causes (1) pressurization of the first compartment (2) the seal structure to convert from the sealed condition to the mixing condition, and (3) contents of the first and second compartments to be mixed and forced through the needle assembly.
12. The automatic injection device of claim 11 , wherein the first compartment comprises a dry medicament component and the second compartment comprises a liquid medicament component.
13. The automatic injection, device of claim 12 , further comprising a dispersion membrane through which the liquid medicament component flows when the seal structure is in the mixing condition after the automatic injection device has been activated causing pressurization of the first compartment.
14. The automatic injection device of claim 13 , wherein the dispersion membrane comprises a hydrophobic acrylic copolymer cast on a non woven nylon support.
15. The automatic injection device of claim 11 , wherein the seal structure further comprises an annular wiper portion disposed at a front end of the outer sealing member and extends axially, the wiper portion positioned to engage an interior wall of the first compartment as the seal structure is moved through the first compartment, the wiper portion configured to direct dry medicament particles engaged with the interior wall radially inward as the seal structure moves through the first compartment when in the mixing condition.
16. The automatic injection device of claim 15 , wherein the annular wiper portion comprises a peripheral lip having an inner surface that extends radially inward as it extends axially rearward.
17. The automatic injection device of claim 11 , wherein the outer sealing member comprises an O-ring that provides an annular seal with the interior wall of the chamber.
18. The automatic injection device of claim 11 , wherein the seal structure has a by-pass zone adjacent the plug in the first position and around the plug in the second position.
19. The automatic injection device of claim 11 , further comprising a plunger rearwardly sealing the second compartment, wherein activation of the activation assembly causes the plunger to contact and move the seal structure through the first compartment toward the needle assembly.
20. The automatic injection device of claim 11 , further comprising an insert mounted in a front end of the chamber adjacent the needle assembly, the insert defining a tapering flow pathway that tapers radially inwardly as it extends axially forward.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/939,647 US20150018761A1 (en) | 2001-07-03 | 2013-07-11 | Seal Structures for Wet/Dry Automatic Injectors |
US14/743,905 US20150283327A1 (en) | 2001-07-03 | 2015-06-18 | Seal Structures for Wet/Dry Automatic Injectors |
US15/147,046 US20160250419A1 (en) | 2000-10-10 | 2016-05-05 | Seal Structures for Wet/Dry Automatic Injectors |
US15/822,441 US20180256824A1 (en) | 2000-10-10 | 2017-11-27 | Seal Structures for Wet/Dry Automatic Injectors |
US16/673,300 US20200069884A1 (en) | 2000-10-10 | 2019-11-04 | Seal Structures for Wet/Dry Automatic Injectors |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/897,422 US6641561B1 (en) | 2000-10-10 | 2001-07-03 | Drug delivery device |
US09/972,202 US6770052B2 (en) | 2000-10-10 | 2001-10-09 | Wet/dry automatic injector assembly |
US10/690,987 US7621887B2 (en) | 2000-10-10 | 2003-10-23 | Wet/dry automatic injector assembly |
US11/698,965 US7749190B2 (en) | 2000-10-10 | 2007-01-26 | Seal structures for wet/dry automatic injectors |
US12/784,595 US8187220B2 (en) | 2000-10-10 | 2010-05-21 | Seal structures for wet/dry automatic injectors |
US13/939,647 US20150018761A1 (en) | 2001-07-03 | 2013-07-11 | Seal Structures for Wet/Dry Automatic Injectors |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/468,421 Continuation US8506526B2 (en) | 2000-10-10 | 2012-05-10 | Seal structures for wet/dry automatic injectors |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/743,905 Continuation US20150283327A1 (en) | 2000-10-10 | 2015-06-18 | Seal Structures for Wet/Dry Automatic Injectors |
Publications (1)
Publication Number | Publication Date |
---|---|
US20150018761A1 true US20150018761A1 (en) | 2015-01-15 |
Family
ID=34549868
Family Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/690,987 Expired - Lifetime US7621887B2 (en) | 2000-10-10 | 2003-10-23 | Wet/dry automatic injector assembly |
US11/698,965 Expired - Fee Related US7749190B2 (en) | 2000-10-10 | 2007-01-26 | Seal structures for wet/dry automatic injectors |
US11/698,964 Expired - Lifetime US7608055B2 (en) | 2000-10-10 | 2007-01-26 | Flow-path inserts for wet/dry automatic injectors |
US11/698,937 Expired - Lifetime US8568367B2 (en) | 2000-10-10 | 2007-01-26 | Needle assemblies for wet/dry automatic injectors |
US12/784,595 Expired - Lifetime US8187220B2 (en) | 2000-10-10 | 2010-05-21 | Seal structures for wet/dry automatic injectors |
US13/468,421 Expired - Lifetime US8506526B2 (en) | 2000-10-10 | 2012-05-10 | Seal structures for wet/dry automatic injectors |
US13/939,647 Abandoned US20150018761A1 (en) | 2000-10-10 | 2013-07-11 | Seal Structures for Wet/Dry Automatic Injectors |
US14/743,905 Abandoned US20150283327A1 (en) | 2000-10-10 | 2015-06-18 | Seal Structures for Wet/Dry Automatic Injectors |
US15/147,046 Abandoned US20160250419A1 (en) | 2000-10-10 | 2016-05-05 | Seal Structures for Wet/Dry Automatic Injectors |
US15/822,441 Abandoned US20180256824A1 (en) | 2000-10-10 | 2017-11-27 | Seal Structures for Wet/Dry Automatic Injectors |
US16/673,300 Abandoned US20200069884A1 (en) | 2000-10-10 | 2019-11-04 | Seal Structures for Wet/Dry Automatic Injectors |
Family Applications Before (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/690,987 Expired - Lifetime US7621887B2 (en) | 2000-10-10 | 2003-10-23 | Wet/dry automatic injector assembly |
US11/698,965 Expired - Fee Related US7749190B2 (en) | 2000-10-10 | 2007-01-26 | Seal structures for wet/dry automatic injectors |
US11/698,964 Expired - Lifetime US7608055B2 (en) | 2000-10-10 | 2007-01-26 | Flow-path inserts for wet/dry automatic injectors |
US11/698,937 Expired - Lifetime US8568367B2 (en) | 2000-10-10 | 2007-01-26 | Needle assemblies for wet/dry automatic injectors |
US12/784,595 Expired - Lifetime US8187220B2 (en) | 2000-10-10 | 2010-05-21 | Seal structures for wet/dry automatic injectors |
US13/468,421 Expired - Lifetime US8506526B2 (en) | 2000-10-10 | 2012-05-10 | Seal structures for wet/dry automatic injectors |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/743,905 Abandoned US20150283327A1 (en) | 2000-10-10 | 2015-06-18 | Seal Structures for Wet/Dry Automatic Injectors |
US15/147,046 Abandoned US20160250419A1 (en) | 2000-10-10 | 2016-05-05 | Seal Structures for Wet/Dry Automatic Injectors |
US15/822,441 Abandoned US20180256824A1 (en) | 2000-10-10 | 2017-11-27 | Seal Structures for Wet/Dry Automatic Injectors |
US16/673,300 Abandoned US20200069884A1 (en) | 2000-10-10 | 2019-11-04 | Seal Structures for Wet/Dry Automatic Injectors |
Country Status (18)
Country | Link |
---|---|
US (11) | US7621887B2 (en) |
EP (3) | EP2308529B1 (en) |
JP (3) | JP4896727B2 (en) |
KR (1) | KR101114630B1 (en) |
CN (1) | CN100574822C (en) |
AU (4) | AU2004285456B2 (en) |
CA (2) | CA2542204C (en) |
CY (2) | CY1113410T1 (en) |
DK (3) | DK2308529T3 (en) |
ES (3) | ES2389842T3 (en) |
HU (1) | HUE029216T2 (en) |
IL (4) | IL175073A (en) |
NO (1) | NO20062215L (en) |
PL (3) | PL2308530T3 (en) |
PT (2) | PT1687047E (en) |
SI (3) | SI2308530T1 (en) |
TW (1) | TWI341214B (en) |
WO (1) | WO2005042067A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10459231B2 (en) | 2016-04-08 | 2019-10-29 | Magic Leap, Inc. | Augmented reality systems and methods with variable focus lens elements |
Families Citing this family (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7621887B2 (en) * | 2000-10-10 | 2009-11-24 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US7544188B2 (en) * | 2001-07-19 | 2009-06-09 | Intelliject, Inc. | Medical injector |
JP3993169B2 (en) | 2002-02-11 | 2007-10-17 | アンタレス・ファーマ・インコーポレーテッド | Intradermal syringe |
TWI252116B (en) * | 2003-07-21 | 2006-04-01 | Ping-De Huang | Safety syringe |
NZ548748A (en) | 2004-02-02 | 2010-09-30 | Bimeda Res & Dev Ltd | Method and device for treating a teat canal of an animal |
US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
GB2453069B (en) | 2004-11-22 | 2009-12-09 | Intelliject Llc | Devices,systems and methods for medicament delivery |
US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
US7947017B2 (en) | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
DK1850892T4 (en) | 2005-01-24 | 2023-06-06 | Antares Pharma Inc | Prefilled needle-assisted syringe injector |
US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
CN101111281B (en) | 2005-02-01 | 2013-02-06 | 因特利杰克特有限公司 | Devices, systems, and methods for medicament delivery |
US8226610B2 (en) | 2005-02-01 | 2012-07-24 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
US7731686B2 (en) | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
US20070060887A1 (en) * | 2005-08-22 | 2007-03-15 | Marsh David A | Ophthalmic injector |
JP4834389B2 (en) * | 2005-11-29 | 2011-12-14 | 前田産業株式会社 | Injection device |
WO2007131025A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Injector with adjustable dosing |
US8251947B2 (en) | 2006-05-03 | 2012-08-28 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US7811252B2 (en) * | 2006-05-17 | 2010-10-12 | Alcon Research, Ltd. | Dosage control device |
US7887521B2 (en) * | 2006-05-17 | 2011-02-15 | Alcon Research, Ltd. | Ophthalmic injection system |
US7871399B2 (en) * | 2006-05-17 | 2011-01-18 | Alcon Research, Ltd. | Disposable ophthalmic injection device |
HUE041691T2 (en) * | 2006-08-31 | 2019-05-28 | Meridian Medical Tech Inc | Vortex feature for drug delivery system |
DE102006045959B3 (en) * | 2006-09-27 | 2008-01-10 | Lts Lohmann Therapie-Systeme Ag | Cylinder piston unit, e.g. for drug syringes with rubber pistons, has a cylinder and a piston guided in the cylinder and sealed with rubber in a sterile manner |
US20080281292A1 (en) * | 2006-10-16 | 2008-11-13 | Hickingbotham Dyson W | Retractable Injection Port |
WO2008108887A2 (en) * | 2006-10-16 | 2008-09-12 | Alcon Research, Ltd. | Method of operating ophthalmic hand piece with disposable end |
US9022970B2 (en) * | 2006-10-16 | 2015-05-05 | Alcon Research, Ltd. | Ophthalmic injection device including dosage control device |
ATE490752T1 (en) * | 2006-10-16 | 2010-12-15 | Alcon Res Ltd | UNIVERSAL RECHARGEABLE ASSEMBLY WITH LIMITED REUSABILITY FOR AN OPHTHALMIC HANDPIECE |
WO2008098860A1 (en) * | 2007-02-14 | 2008-08-21 | Shl Medical Ab | Container for a medical device |
US9566384B2 (en) | 2008-02-20 | 2017-02-14 | Unomedical A/S | Insertion device with horizontally moving part |
US8814834B2 (en) | 2008-03-10 | 2014-08-26 | Antares Pharma, Inc. | Injector safety device |
USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
ES2905719T3 (en) | 2008-05-14 | 2022-04-11 | Biolyph Llc | Reagent mixture preparation and dispensing device and associated methods |
WO2009148969A1 (en) | 2008-06-02 | 2009-12-10 | Sta-Med, Llc | Needle cover assembly for a syringe |
DE102008030268B3 (en) * | 2008-06-19 | 2010-02-04 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Method for filling dual-chamber systems in pre-sterilizable carrier systems and pre-sterilisable carrier system |
EP2318075B1 (en) | 2008-08-05 | 2019-05-22 | Antares Pharma, Inc. | Multiple dosage injector |
EP2328640B1 (en) | 2008-09-18 | 2016-12-21 | Becton, Dickinson and Company | Medical injector with post-autoreconstitution dose setting and autoplunger drive |
ES2845352T3 (en) | 2008-09-18 | 2021-07-26 | Becton Dickinson Co | Needle mounting element to ensure proper reconstitution sequence |
WO2010043685A1 (en) | 2008-10-15 | 2010-04-22 | Novo Nordisk Health Care Ag | System for reconstitution of a powdered drug |
DE102009013211B4 (en) | 2009-03-17 | 2012-04-19 | Aap Biomaterials Gmbh | Bone cement vacuum mixing device and method for mixing bone cement |
CA2755779C (en) | 2009-03-20 | 2015-11-10 | Antares Pharma, Inc. | Hazardous agent injection system |
EP2424596B1 (en) * | 2009-04-30 | 2024-02-28 | Hyperbranch Medical Technology, Inc. | Applicator system for the delivery of surgical sealants |
US8372036B2 (en) | 2009-05-06 | 2013-02-12 | Alcon Research, Ltd. | Multi-layer heat assembly for a drug delivery device |
US8852155B2 (en) * | 2009-08-12 | 2014-10-07 | Medimetrics Personalized Drug Delivery | Medicine reservoir for drug delivery device |
US10350364B2 (en) | 2009-11-11 | 2019-07-16 | Windgap Medical, Inc. | Portable Drug Mixing and Delivery Device and Associated Methods |
US8177747B2 (en) | 2009-12-22 | 2012-05-15 | Alcon Research, Ltd. | Method and apparatus for drug delivery |
US8302776B2 (en) * | 2009-12-30 | 2012-11-06 | Kimberly-Clark Worldwide, Inc. | Pack of oral care items |
US8162882B2 (en) | 2010-06-23 | 2012-04-24 | Sta-Med, Llc | Automatic-locking safety needle covers and methods of use and manufacture |
ES2669185T3 (en) | 2010-06-29 | 2018-05-24 | Biolyph, Llc | Reagent Preparation Set |
US9775956B2 (en) | 2010-07-22 | 2017-10-03 | Becton, Dickinson And Company | Needle assembly for mixing of substances |
WO2012041870A1 (en) * | 2010-10-01 | 2012-04-05 | Sanofi-Aventis Deutschland Gmbh | Needle assembly with release mechanism |
WO2012067619A1 (en) | 2010-11-18 | 2012-05-24 | Biolyph, Llc | Reagent preparation and dispensing device |
JP2014503307A (en) * | 2010-12-30 | 2014-02-13 | メリディアン メディカル テクノロジーズ インコーポレイテッド | Automatic syringe with three chambers |
DK2667856T3 (en) | 2011-01-24 | 2021-08-30 | Otsuka Pharma Co Ltd | MEDICINAL PRODUCT CONTAINING A DRY PREPARATOR COMPOSITION INCLUDING ARIPIPRAZOLE AS AN ACTIVE INGREDIENT AND A DRY PUMP COMPOSITION INCLUDING ARIPIPRAZOLE AS AN ACTIVE INGREDIENT |
US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
EP2495001A1 (en) * | 2011-03-03 | 2012-09-05 | Debiotech S.A. | Cannula inserter |
WO2012166746A1 (en) | 2011-05-31 | 2012-12-06 | Sta-Med, Llc | Blood collection safety devices and methods of use and manufacture |
WO2012177948A2 (en) | 2011-06-21 | 2012-12-27 | Brent Buchine | Automatic mixing device and delivery system |
CA2745320A1 (en) * | 2011-07-06 | 2013-01-06 | Duoject Medical Systems Inc. | Reconstitution device |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
DE102011112516B4 (en) | 2011-09-07 | 2024-02-29 | Stryker European Operations Holdings Llc | Container with a container for holding a liquid and a liquid removal device |
ES2675035T3 (en) | 2011-10-14 | 2018-07-05 | Amgen, Inc | Injector and assembly method |
PT2822618T (en) | 2012-03-06 | 2024-03-04 | Antares Pharma Inc | Prefilled syringe with breakaway force feature |
US9463280B2 (en) * | 2012-03-26 | 2016-10-11 | Medimop Medical Projects Ltd. | Motion activated septum puncturing drug delivery device |
EP2833944A4 (en) | 2012-04-06 | 2016-05-25 | Antares Pharma Inc | Needle assisted jet injection administration of testosterone compositions |
WO2013169800A1 (en) | 2012-05-07 | 2013-11-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
CA3078098C (en) | 2012-06-12 | 2022-03-15 | Alcon Inc. | Intraocular gas injector |
US9398913B2 (en) * | 2012-08-24 | 2016-07-26 | St. Jude Medical Puerto Rico Llc | Sealant storage, preparation, and delivery systems and related methods |
AU2013344674A1 (en) * | 2012-11-14 | 2015-05-14 | Ams Research, Llc | Cell delivery device and system with anti-clumping feature and methods for pelvic tissue treatment |
CA2894462A1 (en) * | 2012-12-14 | 2014-06-19 | Bryan LARSON | Dual medicament carpule for dental syringes |
EP2938376A4 (en) | 2012-12-27 | 2017-01-25 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
PT2953667T (en) | 2013-02-11 | 2020-01-28 | Antares Pharma Inc | Needle assisted jet injection device having reduced trigger force |
US9707354B2 (en) | 2013-03-11 | 2017-07-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
WO2014145959A1 (en) * | 2013-03-15 | 2014-09-18 | Windgap Medical, Inc. | Portable detachable drug mixing and delivery system and method |
JP6560187B2 (en) | 2013-03-15 | 2019-08-14 | ウインドギャップ メディカル インコーポレイテッド | Portable drug mixing and delivery system and method |
US9907910B2 (en) | 2013-03-15 | 2018-03-06 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
US10569017B2 (en) | 2013-03-15 | 2020-02-25 | Windgap Medical, Inc. | Portable drug mixing and delivery device and associated methods |
JP6670740B2 (en) | 2013-03-22 | 2020-03-25 | アムジエン・インコーポレーテツド | Injector and assembly method |
CA2947955C (en) * | 2013-05-17 | 2020-07-07 | Carrtech Llc | Filtering needle cap |
US9707319B2 (en) * | 2013-06-20 | 2017-07-18 | Nordson Corporation | Device and method for improving hydration of a biomaterial |
CA2919154A1 (en) * | 2013-07-16 | 2015-01-22 | Unitract Syringe Pty Ltd | Syringes for prefilled and fill-at-use mixing and drug delivery |
ITRM20130457A1 (en) * | 2013-08-05 | 2015-02-06 | Orofino Pharmaceuticals Group Srl | INTERMEDIATE PRODUCT FOR THE PREPARING OF SYRINGES OR CARTRIDGES WITH DOUBLE CHAMBER AND PRODUCTION PROCEDURE OF SUCH INTERMEDIATE PRODUCT |
US20150059857A1 (en) * | 2013-08-27 | 2015-03-05 | Restek Corporation | Multichambered vial and method of mixing analytical reference materials |
KR102458637B1 (en) | 2013-10-24 | 2022-10-24 | 암겐 인코포레이티드 | Injector and method of assembly |
JP6763772B2 (en) | 2013-12-06 | 2020-09-30 | ジェネンテック, インコーポレイテッド | Devices and methods for small volume drug delivery |
JP6275291B2 (en) * | 2014-03-12 | 2018-02-07 | ウェイ,ミン | Automatic medicine syringe |
US9962336B2 (en) | 2014-05-01 | 2018-05-08 | Sun Pharmaceutical Industries Limited | Extended release suspension compositions |
EP3137060B2 (en) | 2014-05-01 | 2023-12-20 | Sun Pharmaceutical Industries Ltd | Extended release suspension compositions |
US20180104197A9 (en) | 2014-05-01 | 2018-04-19 | Sun Pharmaceutical Industries Limited | Extended release liquid compositions of metformin |
US10258583B2 (en) | 2014-05-01 | 2019-04-16 | Sun Pharmaceutical Industries Limited | Extended release liquid compositions of guanfacine |
WO2016016845A1 (en) * | 2014-07-30 | 2016-02-04 | Sun Pharmaceutical Industries Limited | Dual-chamber pack |
US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
US11116903B2 (en) | 2014-08-18 | 2021-09-14 | Windgap Medical, Inc | Compression seal for use with a liquid component storage vial of an auto-injector |
JP6594410B2 (en) * | 2014-08-18 | 2019-10-23 | ウィンドギャップ メディカル, インコーポレイテッド | Portable drug mixing and delivery device and related methods |
US10765811B2 (en) | 2014-12-08 | 2020-09-08 | Genentech, Inc. | Versatile syringe platform |
AU2015364280A1 (en) | 2014-12-18 | 2017-07-06 | Windgap Medical, Inc. | Method and compositions for dissolving or solubilizing therapeutic agents |
US10485920B2 (en) * | 2015-01-08 | 2019-11-26 | Novo Nordisk A/S | Needle unit with a lockable needle shield and an injection device comprising such a needle unit |
US10695495B2 (en) | 2015-03-24 | 2020-06-30 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
CN107921208B (en) | 2015-04-15 | 2020-12-25 | 温德加普医疗股份有限公司 | Removable activation cap for use with an auto-injector assembly |
US10576206B2 (en) | 2015-06-30 | 2020-03-03 | Kaleo, Inc. | Auto-injectors for administration of a medicament within a prefilled syringe |
US10220147B2 (en) | 2015-08-13 | 2019-03-05 | Windgap Medical, Inc. | Mixing and injection device with sterility features |
CZ2015822A3 (en) * | 2015-11-20 | 2017-03-08 | ChemProtect.SK s.r.o. | An autoinjector |
US20170189272A1 (en) * | 2015-12-30 | 2017-07-06 | Unither Pharmaceuticals | Device for delivering a soluble product with a straw, in particular for children and/or the elderly, adapted cartridge |
US20170231816A1 (en) * | 2016-02-16 | 2017-08-17 | Edwin Ryan | Ophthalmic injection device and method |
WO2017191485A1 (en) * | 2016-05-02 | 2017-11-09 | Sun Pharmaceutical Industries Limited | Dual-chamber pack for pharmaceutical compositions |
US10238803B2 (en) | 2016-05-02 | 2019-03-26 | Sun Pharmaceutical Industries Limited | Drug delivery device for pharmaceutical compositions |
US10369078B2 (en) | 2016-05-02 | 2019-08-06 | Sun Pharmaceutical Industries Limited | Dual-chamber pack for pharmaceutical compositions |
KR101785902B1 (en) * | 2016-08-01 | 2017-10-17 | (주)이화바이오메딕스 | Apparatus for injecting liquid medicine which is capable of injecting additional fluid after completing first injection |
CN110248687B (en) * | 2016-11-01 | 2022-01-11 | 科利登医疗系统公司 | Cartridge-type safety injection system and method |
US10688244B2 (en) | 2016-12-23 | 2020-06-23 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
JP2020507841A (en) | 2017-01-17 | 2020-03-12 | カレオ,インコーポレイテッド | Drug delivery device with wireless connection and event detection |
KR101811846B1 (en) * | 2017-03-15 | 2017-12-22 | 김휘화 | Safety improved semi-automatic syringe |
US10773030B2 (en) * | 2017-07-28 | 2020-09-15 | C&M Tech Co., Ltd. | Safety syringe |
US11679177B2 (en) * | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
JP2021527535A (en) * | 2018-06-20 | 2021-10-14 | コスカ ファミリー リミテッド | Systems and methods for dual-component drug delivery |
US11929160B2 (en) | 2018-07-16 | 2024-03-12 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
US11224537B2 (en) | 2018-10-19 | 2022-01-18 | Alcon Inc. | Intraocular gas injector |
US11357412B2 (en) | 2018-11-20 | 2022-06-14 | 42 Health Sensor Holdings Ltd. | Wearable cardiovascular monitoring device |
WO2020172633A1 (en) * | 2019-02-22 | 2020-08-27 | Credence Medsystems, Inc. | System and method for safety syringe |
JP2022543523A (en) | 2019-08-09 | 2022-10-13 | カレオ,インコーポレイテッド | Device and method for delivery of substances in pre-filled syringes |
TW202302167A (en) | 2021-04-30 | 2023-01-16 | 日商大成化工股份有限公司 | Syringe |
JP1703752S (en) | 2021-05-18 | 2022-01-04 | ||
JP1703754S (en) | 2021-05-18 | 2022-01-04 | ||
JP1703753S (en) | 2021-05-18 | 2022-01-04 | ||
JP1703751S (en) | 2021-05-18 | 2022-01-04 | ||
USD995768S1 (en) | 2021-11-18 | 2023-08-15 | Chugai Seiyaku Kabushiki Kaisha | Syringe barrel |
WO2024072422A1 (en) | 2022-10-01 | 2024-04-04 | CARRTECH Corp. | Filtering needle assembly with seal plug |
Family Cites Families (115)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US836367A (en) * | 1905-10-02 | 1906-11-20 | Henry J Detmers | Hypodermic syringe. |
US1476103A (en) * | 1922-06-21 | 1923-12-04 | Frank L Platt | Hypodermic syringe |
US2098524A (en) * | 1935-04-03 | 1937-11-09 | Arthur E Smith | Syringe |
CH366356A (en) * | 1959-01-29 | 1962-12-31 | Hennings Werner | Needle fastening device for ampoule syringes |
US3096763A (en) * | 1959-07-15 | 1963-07-09 | Robert K Mcconnaughey | Hypodermic syringes and needle hubs therefor |
US3186408A (en) * | 1961-12-29 | 1965-06-01 | Becton Dickinson Co | Hypodermic needle mounting |
CH446620A (en) | 1967-01-31 | 1967-11-15 | Penicillin Ges Dauelsberg & Co | Multi-chamber injection syringe |
US3592245A (en) | 1968-09-24 | 1971-07-13 | American Home Prod | Universal dispensing device for intravenous medications |
FR1598878A (en) | 1968-12-27 | 1970-07-06 | ||
US3757780A (en) * | 1971-02-25 | 1973-09-11 | Ishikawa Susakusho Kk | Needle assembly with longitudinally movable filter |
US3757779A (en) | 1971-05-24 | 1973-09-11 | Century Labor Inc | Filter syringe |
BE792131A (en) | 1972-02-15 | 1973-03-16 | Sherwood Medical Ind Inc | DEVICES FOR INJECTING MEDICINES |
US3807119A (en) * | 1972-06-21 | 1974-04-30 | W Shields | Method of assembling a multiple compartment hypodermic syringe |
DK132690C (en) | 1973-06-15 | 1976-06-21 | H Gram | ASPIRATION CURETTE |
US3938513A (en) | 1974-01-03 | 1976-02-17 | Hargest Thomas S | Syringe filter and valve combination |
US4043335A (en) | 1975-08-23 | 1977-08-23 | Soji Ishikawa | Needle holder device of medical administrating injector |
US4061143A (en) * | 1976-06-10 | 1977-12-06 | Soji Ishikawa | Medical administering needle assembly with filter means |
US4059109A (en) * | 1976-07-27 | 1977-11-22 | Tischlinger Edward A | Mixing and dispensing disposable medicament injector |
US4060082A (en) | 1976-08-16 | 1977-11-29 | Mpl, Inc. | Dual-ingredient medication dispenser |
US4266557A (en) | 1978-01-16 | 1981-05-12 | The Kendall Company | Low friction syringe |
US4215701A (en) | 1978-08-21 | 1980-08-05 | Concord Laboratories, Inc. | Elastomeric plunger tip for a syringe |
US4316462A (en) | 1980-05-21 | 1982-02-23 | Siloam, Inc. | Filtering device for an injection device |
US4306554A (en) | 1980-08-27 | 1981-12-22 | Boris Schwartz | Isolation storage and intermixing syringe for medicants |
DE3278101D1 (en) | 1981-08-10 | 1988-03-17 | Duphar Int Res | Automatic injection syringe |
US4405317A (en) * | 1981-09-30 | 1983-09-20 | The West Company | Syringe assembly |
US4394863A (en) * | 1981-10-23 | 1983-07-26 | Survival Technology, Inc. | Automatic injector with cartridge having separate sequentially injectable medicaments |
US4413991A (en) | 1982-03-18 | 1983-11-08 | Schmitz John B | Dual dose ampule |
EP0112574A1 (en) * | 1982-12-27 | 1984-07-04 | Meditec S.A. | Two-compartment prefilled syringe |
JPS60501193A (en) | 1983-05-04 | 1985-08-01 | メディコープ ホールディング ソシエテ アノニム | Prefilled single dose syringe |
US4599082A (en) | 1984-08-13 | 1986-07-08 | Becton, Dickinson And Company | Two-component syringe assembly |
FR2573310B1 (en) * | 1984-11-20 | 1988-12-30 | Poutrait Morin | BULB FOR HYPODERMIC SYRINGE, IN PARTICULAR SELF-INJECTING SYRINGE |
US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
DE3674483D1 (en) | 1985-06-27 | 1990-10-31 | Duphar Int Res | MULTI-CHAMBER SYRINGE. |
US4613326A (en) | 1985-07-12 | 1986-09-23 | Becton, Dickinson And Company | Two-component medication syringe assembly |
US4861335A (en) | 1985-07-26 | 1989-08-29 | Duoject Medical Systems Inc. | Syringe |
EP0221005A3 (en) * | 1985-09-07 | 1987-12-02 | Wagner, Wolfgang, Dr.med. | Injection device with sensor |
ATE55260T1 (en) | 1985-10-11 | 1990-08-15 | Duphar Int Res | AUTOMATIC SYRINGE. |
US4781701A (en) * | 1986-07-11 | 1988-11-01 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Syringe for medical purposes |
FR2604363A1 (en) | 1986-09-30 | 1988-04-01 | Merieux Inst | DEVICE FOR INJECTING SUBSTANCES, ESPECIALLY MEDICINAL PRODUCTS |
SE457417B (en) | 1987-04-14 | 1988-12-27 | Astra Meditec Ab | AUTOMATIC SQUARE SPRAY, PROCEDURE FOR MIXING AND INJECTION WITH THE SPRAYER AND AMPULA FOR PRIVATE CHAMBER SPRAY |
DE3775054D1 (en) | 1987-06-16 | 1992-01-16 | Akzo Nv | TWO-CHAMBER SYRINGE AND MANUFACTURING METHOD. |
US5364369A (en) | 1987-07-08 | 1994-11-15 | Reynolds David L | Syringe |
GB8723454D0 (en) | 1987-10-06 | 1987-11-11 | Beecham Group Plc | Device |
JPH03500256A (en) | 1987-11-16 | 1991-01-24 | メデイコープ ホールディング ソシエテ アノニム | Liquid substance dispersion equipment |
ES2024564B3 (en) | 1988-02-16 | 1992-03-01 | Arzneimittel Gmbh Apotheker Vetter & Co Ravensburg | SYRINGE FOR MEDICINAL PURPOSES |
GB8809115D0 (en) * | 1988-04-18 | 1988-05-18 | Turner R C | Syringes |
USRE35986E (en) | 1988-08-23 | 1998-12-08 | Meridian Medical Technologies, Inc. | Multiple chamber automatic injector |
GB8819977D0 (en) | 1988-08-23 | 1988-09-21 | Medimech Ltd | Automatic injectors |
DE3916101A1 (en) | 1989-05-17 | 1990-11-22 | Vetter & Co Apotheker | SYRINGE FOR MEDICAL PURPOSES |
US4986820A (en) | 1989-06-23 | 1991-01-22 | Ultradent Products, Inc. | Syringe apparatus having improved plunger |
EP0405320A3 (en) | 1989-06-27 | 1991-04-03 | Elkom - Tovarna Stikalnih Naprav | Multipurpose automatic injector |
DK0440846T3 (en) | 1990-02-07 | 1993-07-12 | Vetter & Co Apotheker | Double chamber syringe and application method |
CA2016870C (en) * | 1990-05-15 | 1994-03-29 | Arnie Drudik | Dispenser for storing and mixing several components |
US5114411A (en) * | 1990-11-19 | 1992-05-19 | Habley Medical Technology Corporation | Multi-chamber vial |
DK288590D0 (en) | 1990-12-04 | 1990-12-04 | Michael Morris | MIXTURE / SOLUTION SPRAY FOR CYTOSTATICS FOR MEDICAL TREATMENT OF CANCER PATIENTS |
GB9100819D0 (en) | 1991-01-15 | 1991-02-27 | Medimech Int Ltd | Subcutaneous injector |
SE9101261D0 (en) | 1991-04-25 | 1991-04-25 | Kabi Pharmacia Ab | INJECTION CONTAINER |
US5259954A (en) | 1991-12-16 | 1993-11-09 | Sepratech, Inc. | Portable intravenous solution preparation apparatus and method |
GB9200219D0 (en) | 1992-01-07 | 1992-02-26 | Medimech Int Ltd | Automatic injectors |
DE69302852T2 (en) * | 1992-03-27 | 1996-09-26 | Duphar Int Res | Automatic syringe |
SE9201247D0 (en) | 1992-04-21 | 1992-04-21 | Kabi Pharmacia Ab | INJECTION DEVICE |
ZA932786B (en) * | 1992-04-30 | 1993-11-16 | Takeda Chemical Industries Ltd | A prefilled syringe |
NZ247392A (en) * | 1992-04-30 | 1995-05-26 | Takeda Chemical Industries Ltd | Prefilled syringe containing two substances mixed before injection |
US5281198A (en) | 1992-05-04 | 1994-01-25 | Habley Medical Technology Corporation | Pharmaceutical component-mixing delivery assembly |
JP3189507B2 (en) * | 1992-06-30 | 2001-07-16 | 株式会社豊田中央研究所 | Surface treatment equipment |
SE9202108D0 (en) | 1992-07-07 | 1992-07-07 | Kabi Pharmacia Ab | DUAL-CHAMBER INJECTION CARTRIDGE |
US5531683A (en) | 1992-08-13 | 1996-07-02 | Science Incorporated | Mixing and delivery syringe assembly |
JPH0629663U (en) | 1992-09-22 | 1994-04-19 | パイオニア株式会社 | Needle with filter |
GB9223183D0 (en) | 1992-11-05 | 1992-12-16 | Medimech Int Ltd | Improvements related to auto injectors |
ES2158886T3 (en) | 1992-12-01 | 2001-09-16 | Tetsuro Higashikawa | SYRINGE. |
US5298024A (en) | 1992-12-28 | 1994-03-29 | Frank Richmond | Multi-liquid medicament delivery system with reflex valves |
US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
US5620421A (en) | 1993-12-09 | 1997-04-15 | Schmitz; William L. | Syringe injector system |
US5795337A (en) | 1994-02-14 | 1998-08-18 | Becton Dickinson And Company | Syringe assembly and syringe stopper |
US5522804A (en) | 1994-02-15 | 1996-06-04 | Lynn; Lawrence A. | Aspiration, mixing, and injection syringe |
CA2154853C (en) | 1994-07-27 | 2007-01-16 | John Glyndwr Wilmot | Nipple plunger |
GB9415554D0 (en) * | 1994-08-02 | 1994-09-21 | Unilever Plc | Cobalt on alumina catalysts |
US5465727A (en) | 1994-08-26 | 1995-11-14 | Brunswick Biomedical Corporation | Twelve-lead portable heart monitor |
US5685846A (en) * | 1995-02-27 | 1997-11-11 | Schott Parenta Systems, Inc. | Dual chamber internal by-pass syringe assembly |
US5637087A (en) | 1995-03-22 | 1997-06-10 | Abbott Laboratories | Prefilled, two-constituent syringe |
GB9506087D0 (en) * | 1995-03-24 | 1995-05-10 | Owen Mumford Ltd | Improvements relating to medical injection devices |
US5618273A (en) * | 1995-03-27 | 1997-04-08 | Ultradent Product, Inc. | Syringe apparatus with threaded plunger for delivering tooth composites and other solid yet pliable materials |
JP3419145B2 (en) * | 1995-04-25 | 2003-06-23 | ニプロ株式会社 | Prefilled syringe |
US5785683A (en) * | 1995-07-17 | 1998-07-28 | Szapiro; Jaime Luis | Disposable syringe with two variable volume chambers |
FR2741810B1 (en) | 1995-11-30 | 1998-02-20 | Soc Et Et D Applic Tech Sedat | SYRINGE FOR THE INJECTION OF AN EXTEMPORANEOUS MIXTURE |
US5735825A (en) | 1996-03-22 | 1998-04-07 | Merit Medical Systems, Inc. | Syringe plunger tip |
AP916A (en) | 1996-05-03 | 2000-12-18 | Nordway Ltd | Vial for use as a syringe accessory. |
US5713857A (en) | 1996-06-28 | 1998-02-03 | Becton Dickinson France, S.A. | Sequential stopper |
US5865798A (en) | 1996-06-28 | 1999-02-02 | Becton Dickinson France, S.A. | Stopper assembly having bypass features for use in a multi-chamber syringe barrel |
US6142977A (en) | 1996-10-18 | 2000-11-07 | Schering Ag | Prefilled, sterilized syringe with a new and improved plug |
US6053895A (en) | 1996-11-05 | 2000-04-25 | Schering Aktiengesellschaft | Syringe with a new and improved plug |
US5782803A (en) | 1996-11-26 | 1998-07-21 | Jentzen; S. William | Low dead space, interchangeable needle syringe |
US6093172A (en) | 1997-02-05 | 2000-07-25 | Minimed Inc. | Injector for a subcutaneous insertion set |
US5807344A (en) | 1997-02-10 | 1998-09-15 | In-X Corporation | Arterial blood gas syringe including filter member |
SE9703425D0 (en) * | 1997-09-23 | 1997-09-23 | Pharmacia & Upjohn Ab | Prefilled ampoules and manufacture thereof |
US5971953A (en) | 1998-01-09 | 1999-10-26 | Bachynsky; Nicholas | Dual chamber syringe apparatus |
JPH11169460A (en) * | 1997-10-09 | 1999-06-29 | Takeda Chem Ind Ltd | Two-chamber type prefilled syringe |
US6189292B1 (en) * | 1998-03-13 | 2001-02-20 | Becton Dickinson And Company | Method and apparatus for manufacturing, filling and packaging medical devices and medical containers |
US6149628A (en) | 1998-07-20 | 2000-11-21 | Szapiro; Jaime Luis | Syringe with two variable volume chambers for containing and administering mixtures of products provided separately |
US5994043A (en) * | 1999-04-05 | 1999-11-30 | Eastman Kodak Company | Color photographic film with inverted blue recording layers |
EP1044697A1 (en) | 1999-04-15 | 2000-10-18 | Mac Clay, Fernando, Horacio | Disposable syringe |
JP4326704B2 (en) * | 1999-04-16 | 2009-09-09 | ベクトン・ディキンソン・アンド・カンパニー | Pen-type syringe with automatic compounding function |
US6368303B1 (en) | 1999-10-15 | 2002-04-09 | Becton, Dickinson And Company | Retracting needle syringe |
JP2001112867A (en) * | 1999-10-18 | 2001-04-24 | Terumo Corp | Syringe containing drug |
AU2351601A (en) | 1999-12-28 | 2001-07-09 | Asger Lau Dalmose | Dual chamber syringe with a dual function piston |
JP2003534879A (en) | 2000-06-08 | 2003-11-25 | メリディアン メディカル テクノロジーズ,インコーポレイテッド | Wet / dry automatic injection assembly |
US6511459B1 (en) | 2000-09-29 | 2003-01-28 | Mallinckrodt Inc. | Syringe plunger having an improved sealing ability |
US7621887B2 (en) * | 2000-10-10 | 2009-11-24 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US6641561B1 (en) * | 2000-10-10 | 2003-11-04 | Meridian Medical Technologies, Inc. | Drug delivery device |
US7556614B2 (en) | 2000-10-10 | 2009-07-07 | Meridian Medical Technologies, Inc. | Separation assembly for drug delivery device |
US6770052B2 (en) | 2000-10-10 | 2004-08-03 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
AR026723A1 (en) * | 2000-12-05 | 2003-02-26 | Szames Leonardo | ELASTIC AND SLIDING VALVE ASSEMBLY SUITABLE TO ACT INSIDE PRELLENED SYRINGES. |
US6387078B1 (en) * | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
US20040049407A1 (en) * | 2002-09-06 | 2004-03-11 | Rosenberg Michael J. | Method and system minimizing drug to food interactions |
US8506826B2 (en) * | 2011-08-02 | 2013-08-13 | Harris Corporation | Method of manufacturing a switch system |
-
2003
- 2003-10-23 US US10/690,987 patent/US7621887B2/en not_active Expired - Lifetime
-
2004
- 2004-10-21 ES ES04795687T patent/ES2389842T3/en active Active
- 2004-10-21 PL PL11153053.1T patent/PL2308530T3/en unknown
- 2004-10-21 DK DK11153043.2T patent/DK2308529T3/en active
- 2004-10-21 PL PL11153043T patent/PL2308529T3/en unknown
- 2004-10-21 PL PL04795687T patent/PL1687047T3/en unknown
- 2004-10-21 EP EP11153043A patent/EP2308529B1/en active Active
- 2004-10-21 ES ES11153043T patent/ES2407305T3/en active Active
- 2004-10-21 SI SI200432317A patent/SI2308530T1/en unknown
- 2004-10-21 EP EP11153053.1A patent/EP2308530B1/en active Active
- 2004-10-21 ES ES11153053T patent/ES2570781T3/en active Active
- 2004-10-21 CA CA2542204A patent/CA2542204C/en active Active
- 2004-10-21 PT PT04795687T patent/PT1687047E/en unknown
- 2004-10-21 DK DK04795687.5T patent/DK1687047T3/en active
- 2004-10-21 EP EP04795687A patent/EP1687047B1/en active Active
- 2004-10-21 SI SI200431920T patent/SI1687047T1/en unknown
- 2004-10-21 AU AU2004285456A patent/AU2004285456B2/en not_active Ceased
- 2004-10-21 DK DK11153053.1T patent/DK2308530T3/en active
- 2004-10-21 CA CA2877357A patent/CA2877357A1/en not_active Abandoned
- 2004-10-21 CN CN200480032490A patent/CN100574822C/en not_active Expired - Fee Related
- 2004-10-21 PT PT111530432T patent/PT2308529E/en unknown
- 2004-10-21 JP JP2006536712A patent/JP4896727B2/en active Active
- 2004-10-21 SI SI200432021T patent/SI2308529T1/en unknown
- 2004-10-21 WO PCT/US2004/034556 patent/WO2005042067A2/en active Application Filing
- 2004-10-21 HU HUE11153053A patent/HUE029216T2/en unknown
- 2004-10-22 TW TW093132179A patent/TWI341214B/en not_active IP Right Cessation
-
2006
- 2006-04-20 IL IL175073A patent/IL175073A/en active IP Right Grant
- 2006-05-16 NO NO20062215A patent/NO20062215L/en not_active Application Discontinuation
- 2006-05-22 KR KR1020067009940A patent/KR101114630B1/en active IP Right Grant
-
2007
- 2007-01-26 US US11/698,965 patent/US7749190B2/en not_active Expired - Fee Related
- 2007-01-26 US US11/698,964 patent/US7608055B2/en not_active Expired - Lifetime
- 2007-01-26 US US11/698,937 patent/US8568367B2/en not_active Expired - Lifetime
-
2010
- 2010-05-06 JP JP2010106654A patent/JP5183671B2/en active Active
- 2010-05-06 JP JP2010106652A patent/JP5491951B2/en active Active
- 2010-05-21 US US12/784,595 patent/US8187220B2/en not_active Expired - Lifetime
- 2010-06-23 AU AU2010202619A patent/AU2010202619B2/en not_active Ceased
- 2010-06-23 AU AU2010202607A patent/AU2010202607B2/en not_active Ceased
-
2012
- 2012-05-10 US US13/468,421 patent/US8506526B2/en not_active Expired - Lifetime
- 2012-06-05 IL IL220195A patent/IL220195A/en active IP Right Grant
- 2012-09-10 CY CY20121100818T patent/CY1113410T1/en unknown
-
2013
- 2013-07-11 US US13/939,647 patent/US20150018761A1/en not_active Abandoned
-
2015
- 2015-06-18 US US14/743,905 patent/US20150283327A1/en not_active Abandoned
-
2016
- 2016-05-05 US US15/147,046 patent/US20160250419A1/en not_active Abandoned
- 2016-05-09 CY CY20161100382T patent/CY1117627T1/en unknown
- 2016-06-23 IL IL246440A patent/IL246440A0/en unknown
-
2017
- 2017-11-27 US US15/822,441 patent/US20180256824A1/en not_active Abandoned
-
2019
- 2019-07-24 IL IL268250A patent/IL268250A/en unknown
- 2019-11-04 US US16/673,300 patent/US20200069884A1/en not_active Abandoned
-
2023
- 2023-08-21 AU AU2023219806A patent/AU2023219806A1/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10459231B2 (en) | 2016-04-08 | 2019-10-29 | Magic Leap, Inc. | Augmented reality systems and methods with variable focus lens elements |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20200069884A1 (en) | Seal Structures for Wet/Dry Automatic Injectors | |
US6641561B1 (en) | Drug delivery device | |
US7556614B2 (en) | Separation assembly for drug delivery device | |
AU2002332808B2 (en) | Drug delivery device | |
AU2022202966A1 (en) | Wet/dry automatic injector assembly | |
IL151579A (en) | Drug delivery device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |