US20130274865A1 - Venous Valve, System, and Method With Sinus Pocket - Google Patents
Venous Valve, System, and Method With Sinus Pocket Download PDFInfo
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- US20130274865A1 US20130274865A1 US13/913,830 US201313913830A US2013274865A1 US 20130274865 A1 US20130274865 A1 US 20130274865A1 US 201313913830 A US201313913830 A US 201313913830A US 2013274865 A1 US2013274865 A1 US 2013274865A1
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- valve
- frame
- leaflets
- bulbous portion
- cross
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2475—Venous valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2436—Deployment by retracting a sheath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49405—Valve or choke making
Abstract
A valve with a frame and valve leaflets that provide a sinus pocket. The valve provides for unidirectional flow of a liquid through the valve.
Description
- This application is a continuation of U.S. application Ser. No. 13/117,770, filed May 27, 2011, issued as U.S. Pat. No. 8,460,365, on Jun. 11, 2013, which is a continuation of U.S. application Ser. No. 12/509,604 filed Jul. 27, 2009, issued as U.S. Pat. No. 7,951,189 on May 31, 2011, which is a continuation of U.S. application Ser. No. 11/232,403, filed Sep. 21, 2005, issued as U.S. Pat. No. 7,569,071 on Aug. 4, 2009, the entire content of which is incorporated herein by reference.
- The present disclosure relates to vascular medical devices, systems and methods; and more particularly to venous valves including a venous valve frame, and methods for forming and using the venous valve frame.
- The venous system of the legs uses valves and muscles as part of the body's pumping mechanism to return blood to the heart. Venous valves create one way flow to prevent blood from flowing away from the heart. When valves fail, blood can pool in the lower legs resulting in swelling and ulcers of the leg. The absence of functioning venous valves can lead to chronic venous insufficiency.
- Techniques for both repairing and replacing the valves exist, but are tedious and require invasive surgical procedures. Direct and indirect valvuoplasty procedures are used to repair damaged valves. Transposition and transplantation are used to replace an incompetent valve. Transposition involves moving a vein with an incompetent valve to a site with a competent valve. Transplantation replaces an incompetent valve with a harvested valve from another venous site.
- Prosthetic valves can be transplanted into the venous system, but current devices are not successful enough to see widespread usage. One reason for this is the very high percentage of prosthetic valves reported with leaflet functional failures. These failures have been blamed primarily on improper sizing and tilted deployment of the prosthetic valve. In addition, a great number of leaflets of the prosthetic valves ultimately become fused to the vein wall.
-
FIGS. 1A and 1B illustrate an embodiment of a venous valve according to the present disclosure. -
FIGS. 2A and 2B illustrate an end view of embodiments of a venous valve according to the present disclosure. -
FIGS. 3A-3E illustrate embodiments of valve frame configurations according to the present disclosure. -
FIG. 4 illustrates an embodiment of a system that includes a valve according to the present disclosure. -
FIG. 5 illustrates an embodiment of a system that includes a valve according to the present disclosure. -
FIGS. 6A , 6B and 6C illustrate an embodiment of a system that includes a valve according to the present disclosure. -
FIGS. 7A , 7B and 7C illustrate an embodiment of a system that includes a valve according to the present disclosure. -
FIGS. 8A , 8B and 8C illustrate an embodiment of a system that includes a valve and a catheter having radiopaque markers according to the present disclosure. - Embodiments of the present disclosure are directed to vascular medical devices, systems and methods for valve replacement and/or augmentation. Particularly, the present disclosure provides venous valve frames, venous valves that utilize the venous valve frames, and methods for forming and using the venous valve frame and the venous valve. Various embodiments of the present disclosure can be used to replace and/or augment an incompetent valve in a body lumen.
- Embodiments of the venous valve include a venous valve frame and valve leaflets that can be implanted through minimally-invasive techniques into the body lumen. In one example, embodiments of the apparatus, system, and method for valve replacement or augmentation may help to maintain antegrade blood flow, while decreasing retrograde blood flow in a venous system of individuals having venous insufficiency, such as venous insufficiency in the legs. Use of valve embodiments can also be possible in other portions of the vasculature.
- The figures herein follow a numbering convention in which the first digit or digits correspond to the drawing figure number and the remaining digits identify an element or component in the drawing. Similar elements or components between different figures may be identified by the use of similar digits. For example, 110 may reference element “10” in
FIG. 1 , and a similar element may be referenced as 210 inFIG. 2 . As will be appreciated, elements shown in the various embodiments herein can be added, exchanged, and/or eliminated so as to provide a number of additional embodiments of valve. In addition, discussion of features and/or attributes for an element with respect to one Fig. can also apply to the element shown in one or more additional Figs. Embodiments illustrated in the figures are not necessarily to scale. -
FIGS. 1A and 1B provide illustrations of various embodiments of avenous valve 100 of the present disclosure. Thevenous valve 100 can be implanted within the fluid passageway of a body lumen, such as for replacement and/or augmentation of a valve structure within the body lumen (e.g., a venous valve). In one embodiment, thevenous valve 100 of the present disclosure may be beneficial to regulate the flow of a bodily fluid through the body lumen in a single direction. -
FIGS. 1A and 1B illustrate one embodiment of thevenous valve 100. Venousvalve 100 includes avenous valve frame 102 andvalve leaflets 104. In one embodiment, thevalve frame 102 and thevalve leaflets 104 of thevenous valve 100 can resiliently radially collapse and expand, as will be described herein. Among other things, thevalve frame 102 and thevalve leaflets 104 define alumen 106 of thevenous valve 100. Thelumen 106 allows for, amongst other things, fluid (e.g., blood) to move through thevenous valve 100. - The
valve frame 102 includes afirst end 108 and asecond end 110 opposite thefirst end 108. Thefirst end 108 and thesecond end 110 define a length of thevalve frame 102 and of thevenous valve 100. In one embodiment, the length ofvenous valve 100 can have a number of values. As will be appreciated, the length ofvenous valve 100 can be determined based upon the location into which thevenous valve 100 is to be implanted. In other words, the length of thevenous valve 100 can be patient specific. Examples of values for the length include, but are not limited to, 20 millimeters to 80 millimeters. Other values are also possible. - The
valve frame 102 can be formed in a wide variety of configurations. For example, thevalve frame 102 can include a firststructural member 112 and a secondstructural member 114 that together form a unitary structure with an open frame configuration. In one embodiment, the firststructural member 112 defines anelongate base portion 116 that extends between thefirst end 108 and thesecond end 110 of thevalve frame 102. As illustrated, the firststructural member 112 defines openings through thevalve frame 102 to provide at least a portion of the open frame configuration. - In addition, the first
structural member 112 also defines a first perimeter value for theelongate base portion 116. In one embodiment, the first perimeter value can be essentially constant for the length of thevalve frame 102. In other words, the outer limit of the area defined by theelongate base portion 116 remains essentially constant along the length of thevalve frame 102. For example, anouter surface 118 of the firststructural member 112 can define a circular cross-sectional area for theelongate base portion 116. As will be appreciated, other cross-sectional shapes are also possible, including but not limited to oval or elliptical. - In an alternative embodiment, the perimeter value changes along the length of the
valve frame 102. For example, theouter surface 118 of the firststructural member 112 can change from a first cross-sectional area having a first value for theelongate base portion 116 adjacent thefirst end 108 and thesecond end 110 to a second cross-sectional area having a second value larger than the first value. In one embodiment, the second cross-sectional area of theouter surface 118 of the firststructural member 112 can, in conjunction with the secondstructural member 114 provide for a circular or round cross-sectional shape. Other cross-sectional shapes are also possible. - In an additional embodiment, the second
structural member 114 helps to define abulbous portion 120 of thevalve frame 102. As illustrated, the secondstructural member 114 extends radially and longitudinally from theouter surface 118 of anarea 122 defined by the firststructural member 112 to form thebulbous portion 120. In one embodiment, the secondstructural member 114 helps to define a second perimeter value for thebulbous portion 120, where second perimeter value can be is greater than the first perimeter value. - As illustrated, the
outer surface 118 of the first and secondstructural members bulbous portion 120 and theelongate base portion 116 having a predefined shape. For example, the firststructural member 112 can define afirst axis 124 of an elliptical shape and the secondstructural member 114 can define asecond axis 126 of the elliptical shape. In one embodiment, the length of thesecond axis 126 can be at least twenty percent (20%) greater than the length of thefirst axis 124. In an additional embodiment, the length of thesecond axis 126 can be twenty percent (20%) to fifty percent (50%) greater than the length of thefirst axis 124. In a further embodiment, the length of thesecond axis 126 can be forty percent (40%) to forty-two percent (42%) greater than the length of thefirst axis 124. - In an additional embodiment, the length of the
second axis 126 can be one (1) to four (4) millimeters greater than the length of thefirst axis 124. As will be more fully discussed herein, this allows for a gap of one-half (0.5) to two (2) millimeters to be maintained between a free edge of thevalve leaflets 104 in their open configuration and thevalve frame 102. In one embodiment, the length of the gap between eachleaflet 104 and thevalve frame 102 can be, but is not necessarily, equal. - In an additional example, the perimeter of the
bulbous portion 120 and theelongate base portion 116 can have a round shape. For example, thefirst axis 124 of thefirst structure member 112 and thesecond axis 126 of the secondstructural member 114 can be essentially of equal length along thebulbous portion 120. -
FIGS. 2A and 2B illustrate embodiments of thevenous valve 200 according to the present disclosure. The embodiments illustrated inFIGS. 2A and 2B are end views of the venous valve illustrated inFIG. 1A taken alonglines 2A-2A/2B-2B. As discussed herein,FIG. 2A illustrates thevenous valve 200 where the firststructural member 212 defining thefirst axis 224 and the secondstructural member 214 defining thesecond axis 226 provide an elliptical shape for thebulbous portion 220 of the valve frame 202.FIG. 2B illustrates thevenous valve 200 where the firststructural member 212 defining thefirst axis 224 and the secondstructural member 214 defining thesecond axis 226 provide a round shape for thebulbous portion 220 of the valve frame 202. - In addition, the first
structural member 112 at each of thefirst end 108 and thesecond end 110 can include afirst curve 128 and asecond curve 130 opposite thefirst curve 128. In one embodiment, the firststructural member 112 forming the first andsecond curve valve 100 radially collapses and expands. In the various embodiments described herein, the first andsecond curve frame valve 102 towards its uncompressed state. As will be appreciated, the first andsecond curve frame 102 from the compression of other portions of thevalve frame 102 as well. - In one embodiment, the first and
second curve ends second curve first end 108 can be positioned radially orthogonal to the first andsecond curve second end 110 of thebase portion 116. As will be appreciated, the first andsecond curve ends - The compressible nature of the
valve 100 can accommodate changes in body lumen size (e.g., diameter of the body lumen) by flexing to expand and/or contract to change the diameter of thevalve frame 102. In one embodiment, the first andsecond curve structural member 112 can act as springs to allow thevalve 100 to resiliently radially collapse and expand. Theframe 102 can also provide sufficient contact and expansion force with the surface of a body lumen wall to encourage fixation of thevalve 100 and to prevent retrograde flow within the body lumen around the edges of theframe 102 and the surface of a lumen when combined with a closed state of the valve leaflets attached thereto. Anchoring elements (e.g., barbs) can also be included withvalve 100. - As will be appreciated, the first and
second curve structural member 112 can also include, but are not limited to, other shapes that allow for repeatable travel between the collapsed state and the expanded state. For example, the elastic regions can include integrated springs having a circular or an elliptical loop configuration. The embodiments are not, however, limited to these configurations as other shapes are also possible. - The first
structural member 112 forming the first andsecond curve radial flare 132 that curves away from a centerlongitudinal axis 134. As illustrated, theradial flare 132 provides for an increase in the peripheral frame dimension at thefirst end 108 and/or thesecond end 110 of thevalve frame 102. In one embodiment, the firststructural member 112 can be pre- and/or post-treated to impart theradial flare 132. For example, the firststructural member 112 forming the first andsecond curve valve frame 102 could be bent to impart theradial flare 132. Theframe 102 could then be heat treated so as to fix theradial flare 132 into the firststructural member 112. Other material treatments (e.g., plastic deformation, forging, elastic deformation with heat setting) are also possible to impart the radial flare as described herein, many of which are material specific. - The first
structural member 112 and/or the secondstructural member 114 of thevalve frame 102 can have similar and/or different cross-sectional geometries and/or cross-sectional dimensions along their length. The similarity and/or the differences in the cross-sectional geometries and/or cross-sectional dimensions can be based on one or more desired functions to be elicited from each portion of theframe 102. For example, the firststructural member 112 and/or the secondstructural member 114 can have a similar cross-sectional geometry along its length. Examples of cross-sectional geometries include, but are not limited to, round (e.g., circular, oval, and/or elliptical), rectangular geometries having perpendicular sides, one or more convex sides, or one or more concave sides; semi-circular; triangular; tubular; I-shaped; T-shaped; and trapezoidal. - Alternatively, the cross-sectional dimensions of one or more geometries of the first
structural member 112 and/or the secondstructural member 114 can change from one portion of theframe 102 to another portion of theframe 102. For example, portions of the firststructural member 112 and/or the secondstructural member 114 can taper (i.e., transition) from a first geometric dimension to a second geometric dimension different than the first geometric dimension. These embodiments, however, are not limited to the present examples as other cross-sectional geometries and dimension are also possible. As such, the present disclosure should not be limited to the frames provided in the illustration herein. - The
valve frame 102 further includes a valveleaflet connection location 136 along the firststructural member 112 of thevalve frame 102. In one embodiment, the valveleaflet connection location 136 includes portions of the firststructural member 112 that can define thearea 122, as well as surfaces of the firststructural member 112 that define openings through theframe 102. For example, the firststructural member 112 can include surfaces that define afirst opening 138 and asecond opening 140 for the valveleaflet connection location 136. In one embodiment, the first andsecond openings bulbous portion 120 of thevalve frame 102. The first andsecond openings common axis 144. In the present illustration, thecommon axis 144 is along thefirst axis 124 of the shape (e.g., elliptical, round) formed by the first and secondstructural member - In an additional embodiment, the valve
leaflet connection location 136 further includes apredefined portion 146 along the firststructural member 112 to which thevalve leaflets 104 can be attached. As illustrated, thepredefined portion 146 includes a portion of the firststructural member 112 that extends between the first andsecond openings bulbous portion 120. In one embodiment, thevalve leaflets 104 can be coupled to thevalve frame 102 through the first andsecond openings predefined portion 146 of the firststructural member 112. - In addition to allowing the
valve leaflets 104 to be coupled to thevalve frame 102, the valveleaflet connection location 140 can also include predetermined dimensional relationships between portions of the valveleaflet connection location 136. For example, predetermined dimensional relationships can exist between the relative positions of the first andsecond openings predefined portion 146 of the firststructural member 112. These dimensional relationships can help to better position thevalve leaflets 104 in relation to thebulbous portion 120 of thevalve frame 102. - For example, as illustrated the
predefined portion 146 of the firststructural member 112 extends away from the first andsecond opening distal point 148 from the first andsecond openings second openings longitudinal axis 134 and in contact with thedistal point 148 is a predetermined length having a value of eighty-five percent (85%) of distance of thesecond axis 126. - In one embodiment, the
valve leaflets 104 include afirst valve leaflet 150 and asecond valve leaflet 152. As illustrated, the first andsecond valve leaflets leaflet connection location 136. The first andsecond valve leaflet commissure 154 that reversibly opens and closes for unidirectional flow of a liquid through thevenous valve 100. As used herein, thecommissure 154 includes portions of thevalve leaflet 104 surfaces that reversibly form a connection to allow fluid to flow through thevalve 100 in essentially one direction. For example, the surfaces of the first andsecond valve leaflets lumen 106 can be restricted and an open configuration in which fluid flow through thelumen 106 can be permitted. - In addition, the first and
second openings central axis 134 of thevalve frame 102. As illustrated, the first andsecond openings central axis 134 of theframe 102. As will be appreciated, the first andsecond openings second openings central axis 134 of theframe 102. - In the present example, the first and
second valve leaflet leaflet connection location 136 and thepredefined portion 146 of thevalve frame 102. As illustrated, thevalve leaflets 104 include aregion 156 of thevalve leaflets 104 that can move relative thevalve frame 102. Theregion 156 of thevalve leaflets 104 can be unbound (i.e., unsupported) by theframe 102 and extends between the first andsecond openings second valve leaflet second openings commissure 154 to reversibly open and close for unidirectional flow of the liquid through thevenous valve 100. - In an additional embodiment, the
valve leaflets 104 in their open configuration have a circumference that is less than the circumference of thevalve frame 102. For example, as illustrated, thevalve leaflets 104 in their open configuration include agap 158 between afree edge 160 of the first andsecond valve leaflets bulbous portion 120 of thevalve frame 102. As discussed herein, the length of thesecond axis 126 can be one (1) to four (4) millimeters greater than the length of thefirst axis 124. In one embodiment, this allows for thegap 158 between thefree edge 160 of eachvalve leaflet 104 in their open position to be one-half (0.5) to two (2) millimeters from thebulbous portion 120 of thevalve frame 102. In one embodiment, the length of thegap 158 between eachleaflet 104 and thevalve frame 102 can be, but is not necessarily, equal. - In one embodiment, the first and
second valve leaflets bulbous portion 120 of thevalve frame 102 provide surfaces that define asinus pocket 162. As illustrated, thesinus pocket 162 provides a dilated channel or receptacle as compared to theelongate base portion 116 of thevenous valve 100. In one embodiment, the presence of thesinus pocket 162 better ensures that thevalve leaflets 104 do not come into contact with a significant portion of thevalve frame 102 and/or the inner wall of the vessel in which thevalve 100 is implanted. For example, thesinus pocket 162 can help prevent adhesion between thevalve leaflets 104 and the vessel wall due to the presence of a volume of blood there between. - The
sinus pocket 162 can also allows forimproved valve leaflets 104 dynamics (e.g., opening and closing of the valve leaflets 104). For example, thesinus pocket 162 can allow for pressure differentials across the surfaces of thevalve leaflets 104 that provide for more rapid closing of thevalve leaflets 104 as the retrograde blood flow begins, as will be discussed herein. - In one embodiment, the
free edge 160 of the first andsecond valve leaflets commissure 154. In one embodiment, thefree edge 160 has a surface that defines acurve 164 between the first andsecond openings curve 164 also has a bottom 166 relative the first andsecond openings free edge 160 can have either a non-planar or a planar configuration. As illustrated, thefree edge 160 of the first andsecond leaflets bottom 166 of thecurve 164 that is at least a predetermined distance away from the secondstructural member 114 so as to define thegap 158 between the first andsecond leaflet structural member 114. - In one embodiment, whether the
free edge 160 has a planar or non-planar configuration can depend on what material is selected for forming thevalve leaflets 104. For example, when a stiffer material (e.g., PTFE) is used for thevalve leaflets 104 thefree edge 160 can have more of a concave shape than a planar or straight shape. In other words, as illustrated inFIG. 1A , thefree edge 160 transitions from a first position adjacent the first andsecond openings second openings free edge 160 dips down to a low point approximately midway between and relative to the first andsecond openings free edge 160 to form a catenary when thevalve leaflets 104 are in their closed position, as illustrated inFIG. 1A . In an alternative embodiment, when an elastic material is used for thevalve leaflets 104 thefree edge 160 has more of a straight or planar shape. In other words, thefree edge 160 maintains essentially the same relative position around the circumference of thevalve leaflets 104. - In addition, the dimensions and configuration of the
valve leaflets 104 can further include proportional relationships to structures of thevalve frame 102. For example, the first andsecond leaflets distal point 148 and thebottom 166 of thecurve 164 that is at least fifty percent (50%) greater than a radius of theelongate base portion 116. In one embodiment, this dimensional relationship is taken when thevalve leaflets 104 are in their closed position. - In addition to allowing the
valve leaflets 104 to be coupled to thevalve frame 102, the valveleaflet connection location 136 can also include predetermined dimensional relationships between portions of the valveleaflet connection location 136. For example, predetermined dimensional relationships can exist between the relative positions of the first andsecond openings predefined portion 146 of the firststructural member 112. These dimensional relationships can help to better position thevalve leaflets 104 in relation to thebulbous portion 120 of thevalve frame 102. - In an additional embodiment, a predetermined portion of the surfaces of the
valve leaflets commissure 154 can extend parallel to the centerlongitudinal axis 134 of thevenous valve 100 when thevalve 100 is in its closed configuration (FIG. 1A ). For example, the predetermined portion of the surfaces of thevalve leaflets valve leaflets distal point 148 and thebottom 166 of thecurve 164. In other words, at least twenty percent (20%) of the length of thevalve leaflet commissure 154. - As will be appreciated, the
free edge 160 when thevalve leaflets 104 are in their open configuration can have a non-round shape. For example, thefree edge 160 can have an eye shape or an oval shape with the second axis extending between the first andsecond openings valve leaflets 104 in their open configuration are also possible, including a round shape. - In one embodiment, under antegrade fluid flow (i.e., positive fluid pressure) from the
second end 110 towards thefirst end 108 of thevalve 100, thevalve leaflets 104 can expand toward theinner surface 170 of thebulbous portion 120 of theframe 102 to create an opening through which fluid is permitted to move. In one example, thevalve leaflets 104 each expand to define a semi-tubular structure having an oval cross-section when fluid opens thecommissure 154. - As discussed herein, in the open configuration the
gap 158 exists between thefree edge 160 of the first andsecond valve leaflets bulbous portion 120 of thevalve frame 102. In one embodiment, the size and shape of thevalve leaflets 104 provides thegap 158 thereby preventing thevalve leaflets 104 from touching the vein wall. - In addition, the size and shape of the
valve leaflets 104 along with thegap 158 provides for more responsive opening and closing of thecommissure 154 due to hydrodynamic relationships that are formed across thevalve leaflets 104. For example, as theleaflets 104 are not in contact with the vessel wall and/or thebulbous portion 120 of theframe 102, theleaflets 104 can be more responsive to changes in the flow direction. The presence of thesinus pocket 162 allows slower moving fluid (e.g., blood) to move into the pocket and faster moving blood on the flow side of theleaflet 104 to create a pressure differential. This pressure differential across thevalve leaflets 104 provides for the Bernoulli effect for which an increase in fluid flow velocity there occurs simultaneously a decrease in pressure. So, as fluid flow becomes retrograde the fluid velocity through the opening of thevalve leaflets 104 is larger than the fluid flow in thesinus pocket 162. As a result, there is a lower pressure in the opening of thevalve leaflets 104 that causes the opening to close more quickly as compared to valves without thesinus pocket 162. - In an additional embodiment, the configuration of the present embodiments allows the
leaflets 104 to experience a low shear as compared to angled leaflets which are subject to high shear and direct impact with flowing blood. This can be attributed to the alignment of thevalve leaflets 104 with theelongate base portion 116, and the adjacent vein segment, above and below thesinus pocket 162. Thesinus pocket 162 also allows for recirculation of blood within thepocket 162 that cleans out potential thrombus buildup in the bottom of thepocket 162. -
Valve 100 provides an embodiment in which the surfaces defining thecommissure 154 provide a bi-leaflet configuration (i.e., a bicuspid valve) forvalve 100. Although the embodiments inFIGS. 1A and 1B illustrate and describe a bi-leaflet configuration for the valve of the present disclosure, designs employing a different number of valve leaflets (e.g., tri-leaflet valve) may be possible. For example, additional connection points (e.g., three or more) could be used to provide additional valve leaflets (e.g., a tri-leaflet valve). - The embodiments of the frame described herein can also be constructed of one or more of a number of materials and in a variety of configurations. The frame embodiments can have a unitary structure with an open frame configuration. The frame can also be self-expanding. Examples of self-expanding frames include those formed from temperature-sensitive memory alloy which changes shape at a designated temperature or temperature range, such as Nitinol. Alternatively, the self-expanding frames can include those having a spring-bias. In addition, the
valve frame 102 can have a configuration that allows the frame embodiments be radially expandable through the use of a balloon catheter. In this embodiment, the valve frame can be provided in separate pieces (e.g., two frame pieces) that are delivered individually to the implant site. - The embodiments of the
frame 102 can also be formed from one or more contiguous frame members. For example, the first and secondstructural member frame 102 can be formed from a single contiguous member. The single contiguous member can be bent around an elongate tubular mandrel to form the frame. The free ends of the single contiguous member can then be welded, fused, crimped, or otherwise joined together to form the frame. In an additional embodiment, the first and secondstructural member frame 102 can be derived (e.g., laser cut, water cut) from a single tubular segment. In an alternative embodiment, methods of joining the first and secondstructural member frame 102 to create the elastic region include, but are not limited to, welding, gluing, and fusing the frame member. Theframe 102 can be heat set by a method as is typically known for the material which forms theframe 102. - The
valve frame 102 can be formed from a number of materials. For example, the frame can be formed from a biocompatible metal, metal alloy, polymeric material, or combination thereof. As described herein, the frame can be self-expanding or balloon expandable. In addition, the frame can be configured so as to have the ability to move radially between the collapsed state and the expanded state. Examples of suitable materials include, but are not limited to, medical grade stainless steel (e.g., 316L), titanium, tantalum, platinum alloys, niobium alloys, cobalt alloys, alginate, or combinations thereof. Additional frame embodiments may be formed from a shape-memory material, such as shape memory plastics, polymers, and thermoplastic materials. Shaped memory alloys having superelastic properties generally made from ratios of nickel and titanium, commonly known as Nitinol, are also possible materials. Other materials are also possible. - The
lumen 106 can include a number of sizes. For example, the size of the lumen can be determined based upon the type of body lumen and the body lumen size in which the valve is to be placed. In an additional example, there can also be a minimum value for the width for the frame that ensures that the frame will have an appropriate expansion force against the inner wall of the body lumen in which the valve is being placed. - The
valve 100 can further include one or more radiopaque markers (e.g., rivets, tabs, sleeves, welds). For example, one or more portions of the frame can be formed from a radiopaque material. Radiopaque markers can be attached to, electroplated, dipped and/or coated onto one or more locations along the frame. Examples of radiopaque material include, but are not limited to, gold, tantalum, and platinum. - The position of the one or more radiopaque markers can be selected so as to provide information on the position, location and orientation (e.g., axial, directional, and/or clocking position) of the valve during its implantation. For example, radiopaque markers can be configured radially and longitudinally (e.g., around and along portions of the first structural member 112) on predetermined portions of the
valve frame 102 to allow the radial and axial position of thevalve frame 102 to be determined. So in one embodiment a radiograph image of thevalve frame 102 taken perpendicular to thevalve leaflets 104 in a first clock position can produce a first predetermined radiograph image (e.g., an imaging having the appearance of an inverted “Y”) and a radiographic image taken perpendicular to the first andsecond openings - In one embodiment, the first and second predetermined radiograph images allow the radial position of the
leaflets 104 to be better identified within the vessel. This then allows a clocking position for thevalve 100 to be determined so that the valve can be positioned in a more natural orientation relative the compressive forces the valve will experience in situ. In other words, determining the clocking of the valve as described herein allows the valve to be radially positioned in same orientation as native valve that it's replacing and/or augmenting. - In one embodiment, the material of the
valve leaflets 104 can be sufficiently thin and pliable so as to permit radially-collapsing of thevalve leaflets 104 for delivery by catheter to a location within a body lumen. Thevalve leaflets 104 can be constructed of a fluid-impermeable biocompatible material that can be either synthetic or biologic. Possible synthetic materials include, but are not limited to, expanded polytetrafluoroethylene (ePTFE), polytetrafluoroethylene (PTFE), polystyrene-polyisobutylene-polystyrene (SIBS), polyurethane, segmented poly(carbonate-urethane), Dacron, polyethlylene (PE), polyethylene terephthalate (PET), silk, Rayon, Silicone, or the like. Possible biologic materials include, but are not limited to, autologous, allogeneic or xenograft material. These include explanted veins and decellularized basement membrane materials (such as non-crosslinked bladder membrane or amnionic membrane), such as small intestine submucosa (SIS) or umbilical vein. As will be appreciated, blends or mixtures of two or more of the materials provided herein are possible. For example, SIBS can be blended with one or more basement membrane materials. - As described herein, a number of methods exist for attaching the
valve leaflets 104 to thevalve frame 102. For example, when positioned over theinter surface 114 of theframe 102, thevalve leaflets 104 can be secured to theframe members 118 through the use of biocompatible staples, glues, sutures or combinations thereof. In an additional embodiment, thevalve leaflets 104 can be coupled to theframe members 118 through the use of heat sealing, solvent bonding, adhesive bonding, or welding thevalve leaflets 104 to either a portion of the valve leaflets 104 (i.e., itself) and/or theframe 102. - With respect to coupling the
valve leaflets 104 to the first andsecond openings leaflet connection location 136, thevalve leaflets 104 can be passed from theinner surface 170 of the firststructural member 112 and wrapped around at least a portion of theouter surface 118 adjacent the first andsecond openings valve leaflets 104 at the first andsecond openings valve leaflets 104 adjacent the first andsecond openings second openings second openings inner surface 170 around theframe 102 to theouter surface 118. Thevalve leaflets 104 can then be coupled to itself and/or theframe 102, as described herein. In addition, sutures can be passed through the first andsecond openings valve leaflets 104 so as to secure thevalve leaflets 104 to theframe 102. In one embodiment, providing the flaps as described allows for thevalve leaflets 104 to create a more fluidtight commissure 154 in the area adjacent the first andsecond openings - The
valve leaflets 104 can have a variety of sizes and shapes. For example, each of thevalve leaflets 104 can have a similar size and shape. Alternatively, each of thevalve leaflets 104 need not have a similar size and shape (i.e., the valve leaflets can have a different size and shape with respect to each other). - In an additional embodiment, the
valve leaflets 104 can include one or more support structures, where the support structures can be integrated into and/or onto thevalve leaflets 104. For example, thevalve leaflets 104 can include one or more support ribs having a predetermined shape. In one embodiment, the predetermined shape of the support ribs can include a curved bias so as to provide thevalve leaflets 104 with a curved configuration. Support ribs can be constructed of a flexible material and have dimensions (e.g., thickness, width and length) and cross-sectional shape that allows the support ribs to be flexible when thevalve leaflets 104 are urged into an open position, and stiff when thevalve leaflets 104 are urged into a closed position upon experiencing sufficient back flow pressure from the direction downstream from the valve. In an additional embodiment, support ribs can also be attached to frame 102 so as to impart a spring bias to the valve leaflets in either the open or the closed configuration. - As described herein, the
valve leaflets 104 can be located over at least theinner surface 170 of theframe 102.FIGS. 1A and 1B illustrate an embodiment of this configuration, where the material of thevalve leaflets 104 extends over theinner surface 170 and theouter surface 118 of the firststructural member 112 in the valveleaflet connection location 136, as described herein. Numerous techniques may be employed to laminate or bond the material of thevalve leaflets 104 on theouter surface 118 and/or theinner surface 170 of theframe 102, including heat setting, adhesive welding, application of uniform force and other bonding techniques. The material of thevalve leaflets 104 can also be joined to itself and/or the firststructural member 112 according to the methods described in U.S. Patent Application Publication US 2002/0178570 to Sogard et al., which is hereby incorporated by reference in its entirety. - The material can also be coupled to the valve
leaflet connection location 136 of the firststructural member 112 so as to form thevalve leaflets 104, as described herein. In one embodiment, the material for thevalve leaflets 104 can be in the form of a sheet or a sleeve of material, as described herein, which can be connected to theframe 102. Alternatively, the material for thevalve leaflets 104 can initially be in the form of a liquid that can be used to cast and/or form thevalve leaflets 104 over theframe 102. Other forms, including intermediate forms, of thevalve leaflets 104 are also possible. - The material of the
valve leaflets 104 can be coupled to the valveleaflet connection location 136 of the firststructural member 112, including the first andsecond openings valve leaflets 104 to theframe 102 so as to form thevalve 100. Suitable fasteners can include, but are not limited to, biocompatible staples, glues, sutures or combinations thereof. In an additional embodiment, the material of thevalve leaflets 104 can be coupled to theframe 102 through the use of heat sealing, solvent bonding, adhesive bonding, or welding the material of thevalve leaflets 104 to either a portion of the valve leaflets 104 (i.e., itself) and/or theframe 102. - The
valve leaflets 104 may also be treated and/or coated with any number of surface or material treatments. For example, thevalve leaflets 104 can be treated with one or more biologically active compounds and/or materials that may promote and/or inhibit endothelization and/or smooth muscle cell growth of thevalve leaflets 104. Similarly, thevalve leaflets 104 may be seeded and covered with cultured tissue cells (e.g., endothelial cells) derived from a either a donor or the host patient which are attached to thevalve leaflets 104. The cultured tissue cells may be initially positioned to extend either partially or fully over thevalve leaflets 104. -
Valve leaflets 104 can also be capable of inhibiting thrombus formation. Additionally,valve leaflets 104 may either prevent or facilitate tissue ingrowth there through, as the particular application for thevalve 100 may dictate. For example,valve leaflets 104 on theouter surface 112 may be formed from a porous material to facilitate tissue ingrowth there through, whilevalve leaflets 104 on theinner surface 114 may be formed from a material or a treated material which inhibits tissue ingrowth. -
FIGS. 3A through 3E provide illustrations of different configurations of thevalve frame 302 that have been cut to provide them in a planar view. As illustrated, thevalve frame 302 includes the first and secondstructural members elongate base portion 316 and thebulbous portion 320, respectively. In one embodiment, the first and secondstructural members elongate base portion 316 and thebulbous portion 320 can include a series of interconnected members. These interconnected members, in one embodiment, can act as spring members to help retain the expanded shape of thevalve frame 302. In one embodiment, the interconnection of these members allows for the spring force of aligned springs integrated into theframe 302 to be added in series so as to increase the spring force potential of theframe 302. - As illustrated, the first and second
structural members elongate base portion 316 and thebulbous portion 320. As will be appreciated, other configurations are possible that provide thebulbous portion 320 and/or theelongate base portion 316. In addition, thebulbous portion 320 of thevalve frame 302 can have a number of different configurations so as to provide the sinus pocket, as discussed herein. For example, thebulbous portion 320 can have one or more of a spherical, semi-spherical, oviod, semi-oviod, conical, semi-conical, torus, semi-torus, cylindrical, and semi- cylindrical. In addition, each of two or more of the sinus pockets of thevalve frame 302 can have different shapes as discussed herein. In other words, the need not have the same shape as the other sinus pocket of thevalve frame 302. - In addition, the first and second
structural members structural members elongate base portion 316 and/or thebulbous portion 320 as compared to the remainder of the elongate base and/orbulbous portion - As illustrated, the
valve frame 302 can include the valve leaflet connection region 336 for coupling the valve leaflets. As discussed herein, the valve leaflet connection region 336 can include the first andsecond opening predetermined portion 346 of the firststructural member 312. -
FIG. 4 illustrates one embodiment of asystem 480.System 480 includesvalve 400, as described herein, reversibly joined tocatheter 482. Thecatheter 482 includes anelongate body 484 having aproximal end 486 and adistal end 488, wherevalve 400 can be located between theproximal end 486 anddistal end 488. Thecatheter 482 can further include alumen 490 longitudinally extending to thedistal end 488. In one embodiment,lumen 490 extends betweenproximal end 486 anddistal end 488 ofcatheter 482. Thecatheter 482 can further include aguidewire lumen 492 that extends within theelongate body 484, where theguidewire lumen 492 can receive a guidewire for positioning thecatheter 482 and thevalve 400 within a body lumen (e.g., a vein of a patient). - The
system 480 can further include adeployment shaft 494 positioned withinlumen 490, and asheath 496 positioned adjacent thedistal end 488. In one embodiment, thevalve 400 can be positioned at least partially within thesheath 496 and adjacent thedeployment shaft 494. For example, thevalve 400 can be fully or partially sheathed with thesheath 496. Thedeployment shaft 494 can be moved within thelumen 490 to deployvalve 400. For example,deployment shaft 494 can be used to pushvalve 400 fromsheath 496 in deployingvalve 400. -
FIG. 5 illustrates an additional embodiment of thesystem 580. Thecatheter 582 includeselongate body 584,lumen 590, aretraction system 598 and aretractable sheath 596. Theretractable sheath 596 can be positioned over at least a portion of theelongate body 584, where theretractable sheath 596 can move longitudinally along theelongate body 584. Thevalve 500 can be positioned at least partially within theretractable sheath 596, where theretractable sheath 596 moves along theelongate body 596 to deploy thevalve 500. For example, thevalve 500 can be fully or partially sheathed with thesheath 596. - In one embodiment,
retraction system 598 includes one ormore wires 501 coupled to theretractable sheath 596, where the wires are positioned at least partially within and extend throughlumen 590 in theelongate body 584. Wires of theretraction system 598 can then be used to retract theretractable sheath 596 in deployingvalve 500. In one embodiment, a portion of theelongate body 584 that defines theguidewire lumen 592 extends through the lumen 506 of thevalve 500 to protect thevalve 500 from the movement of theguidewire 509. -
FIGS. 6A-6C illustrate an additional embodiment of thesystem 680. Thesystem 680 includes atubular sheath 611 having anelongate body 613 and alumen 615. Thesystem 680 further includes adelivery shaft 617 positioned within thelumen 615 of thetubular sheath 611. In one embodiment, thetubular sheath 611 and thedelivery shaft 617 can move longitudinally relative each other. - In one embodiment, the
system 680 includes aflexible cover 619 between thetubular sheath 611 and thedelivery shaft 617. In one embodiment, theflexible cover 619 is connected to thetubular sheath 611 and thedelivery shaft 617 at a fluidtight seal 621 so as to prevent the transmission of friction from theelongate body 613 todevice 600 while theelongate body 613 is retracted during the deployment cycle. In one embodiment, this can be accomplished by creating intentional friction surfaces between theelongate body 613 andflexible cover 619 as is demonstrated inFIG. 6A or two layers of theflexible cover 619 as is demonstrated inFIG. 6B . - In one embodiment, the
tubular sheath 611, thedelivery shaft 617 and theflexible cover 619 can each be formed from a number of different materials. For the tubular sheath examples include, but are not limited to materials selected from one or more of ePTFE, PTFE, PE, PET, silicone, and polyurethanes. For thedelivery shaft 617 examples include, but are not limited to, those selected from a metal, a metal alloy, and/or a polymer. Examples include, but are not limited one or more of ePTFE, PTFE, PE, nylons, PET, silicone, polyurethanes, and stainless steel (e.g., 316L). - In addition, the
delivery shaft 617 can also include a configuration that imparts sufficient column rigidity to allow it to be pushed and/or pulled through thelumen 615. For example, thedelivery shaft 617 can be formed with reinforcing members bound within the body of the delivery shaft 617 (e.g., an elongate braid of stainless steel co-extruded with a polymer). For theflexible cover 619 examples include, but are not limited to, materials selected from one or more of ePTFE, PTFE, PE, PET, nylons, and polyurethanes. As will be appreciated, other materials and configurations for forming thetubular sheath 611, thedelivery shaft 617 and theflexible cover 619 are also possible. - As illustrated in
FIGS. 6A-6C , thevalve 600 can be positioned over thedelivery shaft 615 adjacent adistal end 623 of thedelivery shaft 617. In addition, thevalve 600 can be held in the samerelative location 625 as it is being deployed. As illustrated inFIG. 6A , thevalve 600, a portion of theflexible cover 619 and thedelivery shaft 617 can be positioned within thelumen 615 of thetubular sheath 611. In one embodiment, the configuration illustrated inFIG. 6A allows thevalve 600 to be delivered in its compressed state to a predetermined location in the lumen of the body. Once at the predetermined location, thesheath 611 can then be moved relative thedelivery shaft 617.FIG. 6B illustrates a situation where thesheath 611 has been pulled over thevalve 600location 625 and at least partially over thedelivery shaft 617. - As illustrated, the
flexible cover 619 has a tubular configuration that folds back inside of itself (i.e., its lumen) as thetubular sheath 611 is drawn over thevalve 600 and thedelivery shaft 617. In one embodiment, thelumen 615 of thesheath 611 can contain a lubricating fluid (e.g., saline) to allow theflexible cover 619 to more easily pass over itself as illustrated. As thetubular sheath 611 continues to be pulled back relative thedelivery shaft 617 until thevalve 600 is released, as illustrated inFIG. 6C . In one embodiment, thevalve 600 can include a self-expanding frame that allows thevalve 600 to deploy atlocation 625 once released. -
FIGS. 7A-7C illustrate an additional embodiment of thesystem 780. Thesystem 780 includes atubular sheath 711 having anelongate body 713 and alumen 715. Thesystem 780 further includes adelivery shaft 717 positioned within thelumen 715 of thetubular sheath 711. In one embodiment, thetubular sheath 711 and thedelivery shaft 717 can move longitudinally relative each other. In contrast to the system illustrated inFIGS. 6A-6C , however, thesystem 780 does not include the flexible cover. As a result, the illustrated embodiment ofsystem 780 allows for an increase in the size of the inner diameter of theelongate body 713 to be used by the delivery shaft and/or thevalve 700 as compared to the elongate body that includes the flexible cover. - In one embodiment, the
tubular sheath 711 and thedelivery shaft 717 can each be formed from materials and have configurations as discussed herein forFIGS. 6A-6C . As illustrated inFIGS. 7A-7C , thevalve 700 can be positioned over thedelivery shaft 715 adjacent adistal end 723 of thedelivery shaft 717. In addition, thevalve 700 can be held in the samerelative location 725 as it is being deployed. As illustrated inFIG. 7A , thevalve 700 and thedelivery shaft 717 can be positioned within thelumen 715 of thetubular sheath 711. In one embodiment, the configuration illustrated inFIG. 7A allows thevalve 700 to be delivered in its compressed state to a predetermined location in the lumen of the body. Once at the predetermined location, thesheath 711 can then be moved relative thedelivery shaft 717.FIG. 7B illustrates a situation where thesheath 711 has been pulled at least partially over thevalve 700 atlocation 725 and at least partially over thedelivery shaft 717. As thetubular sheath 711 continues to be pulled back relative thedelivery shaft 717 thevalve 700 is released, as illustrated inFIG. 7C . In one embodiment, thevalve 700 can include a self-expanding frame that allows thevalve 700 to deploy atlocation 725 once released. - The embodiments of the present disclosure further include methods for forming the valve of the present disclosure, as described herein. For example, the valve frame can be formed in a number of different ways. In one embodiment, the valve frame can be formed by cutting a tube of material so as to form the first structural member into the elongate base portion and/or the second structural member into the bulbous portion of the valve frame. Examples of techniques for cutting include laser cutting and/or water jet cutting. Other cutting techniques are also possible. When the first structural member and the second structural member are formed separately, the two portions can be joined by a welding technique, such as laser welding. Other welding or bonding techniques are also possible.
- Forming the second structural member into the bulbous portion that radially and longitudinally extends from the first structural member can be accomplished through a variety of techniques. For example, the tube of material that is cut to form the first and second structural members can either be formed with or have a bulbous portion bent into the tube of material. In other words, the tube has the bulbous portion before cutting out the first and second structural members.
- Alternatively, the first and second structural members can be cut from the tube. The bulbous portion can then be bent into the second structural members of the valve frame to form the bulbous portion. As discussed herein, forming the bulbous portion can include shaping the first structural member and the second structural member into a predetermined shape, such as elliptical or round. Other shapes for the bulbous portion are also possible.
- The valve frame can then be positioned over a mandrel having surfaces that support the elongate base portion and the bulbous portion of the valve frame. Once positioned, the valve frame can then be processed according to the material type used for the frame. For example, the valve frame can be heated on the mandrel to set the shape of the valve frame according to techniques as are known.
- The method also includes providing the material in predefined shapes for the valve leaflets. The valve leaflet material is applied and coupled to the valve leaflet connection location of the valve frame, as discussed herein, to provide at least the first leaflet and the second leaflet of the valve having surfaces defining the reversibly sealable opening for unidirectional flow of a liquid through the valve. In one embodiment, the opening defined by the valve leaflets can be configured, as discussed herein, to create a Bernoulli Effect across the valve leaflets.
- In one embodiment, coupling the material of the valve leaflets to the venous valve frame includes locating the free edge of the valve leaflets adjacent the bulbous portion to provide both the gap and the sinus pocket between the bulbous portion in the venous valve frame and the valve leaflets. As discussed herein, coupling the material of the valve leaflets to the venous valve frame can include configuring the valve leaflets such that at least the gap between the free edge of the valve leaflets and the bulbous portion in the venous valve frame is maintained as the valve leaflets cycles between their opened and closed position.
- In an additional example, the valve can be reversibly joined to the catheter, which can include a process of altering the shape of the valve from a first shape, for example an expanded state, to the compressed state, as described herein. For example, the valve can be reversibly joined with the catheter by positioning valve in the compressed state at least partially within the sheath of the catheter. In one embodiment, positioning the valve at least partially within the sheath of the catheter includes positioning the valve in the compressed state adjacent the deployment shaft of the catheter. In an another embodiment, the sheath of the catheter functions as a retractable sheath, where the valve in the compressed state can be reversibly joined with the catheter by positioning the valve at least partially within the reversible sheath of the catheter. In a further embodiment, the catheter can include an inflatable balloon, where the balloon can be positioned at least partially within the lumen of the valve, for example, in its compressed state.
- The embodiments of the valve described herein may be used to replace, supplement, or augment valve structures within one or more lumens of the body. For example, embodiments of the present disclosure may be used to replace an incompetent venous valve and help to decrease backflow of blood in the venous system of the legs.
- In one embodiment, the method of replacing, supplementing, and/or augmenting a valve structure can include positioning at least part of the catheter including the valve at a predetermined location within the lumen of a body. For example, the predetermined location can include a position within a body lumen of a venous system of a patient, such as a vein of a leg.
- In one embodiment, positioning the catheter that includes the valve within the body lumen of a venous system includes introducing the catheter into the venous system of the patient using minimally invasive percutaneous, transluminal catheter based delivery system, as is known in the art. For example, a guidewire can be positioned within a body lumen of a patient that includes the predetermined location. The catheter, including valve, as described herein, can be positioned over the guidewire and the catheter advanced so as to position the valve at or adjacent the predetermined location.
- As described herein, the position of the one or more radiopaque markers can be selected so as to provide information on the position, location and orientation (e.g., axial, directional, and/or clocking position) of the valve during its implantation. For example, radiopaque markers can be configured radially and longitudinally on predetermined portions of the valve frame and/or the elongate body of the catheter to indicate not only a longitudinal position, but also a radial position of the valve leaflets and the valve frame (referred to as a clock position). In one embodiment, the radiopaque markers are configures to provide radiographic images that indicate the relative radial position of the valve and valve leaflets on the catheter.
-
FIGS. 8A-8C provide an illustration of theradiopaque markers 827 associated with theelongate body 884 of thecatheter 882. As illustrated, theradiopaque markers 827 include aradial component 829 and alongitudinal component 831. Depending upon the radial position of thecatheter 882, theradiopaque markers 827 can provide a different and distinguishable radiographic image. For example, in afirst position 833 illustrated inFIG. 8A thelongitudinal component 831 of theradiopaque markers 827 are aligned so as to overlap. As thecatheter 882 is rotated, as illustrated inFIGS. 8B and 8C , the radiographic image of theradial component 829 and/orlongitudinal component 831 of theradiopaque markers 827 changes. - The change in the relationship of the radial and
longitudinal components catheter 882 is rotated allows for the relative position of thevalve 800, valve frame and valve leaflets to be determined from the radiographic image. For example, the relative position of the first and secondleaflet connection regions longitudinal component 831 of theradiopaque markers 827. This would allow the clock position for thevalve 800 to be determined so that the valve can be positioned in a more natural orientation relative the compressive forces the valve will experience in situ. In other words, the allowing for clocking of thevalve 800 as described herein allows the valve to be radially positioned in same orientation as native valve that it's replacing and/or augmenting. - As will be appreciated, other relative relationships between the
radiopaque markers 827 and the position of thevalve 800 on thecatheter 882 are possible. So, embodiments of the present disclosure should not be limited to the present example. For example, additionalradiopaque markers 827 on thevalve 800 could be used either alone or in combination withradiopaque markers 827 on thecatheter 882 to help in positioning thevalve 800 within a lumen. - The valve can be deployed from the catheter at the predetermined location in a number of ways, as described herein. In one embodiment, valve of the present disclosure can be deployed and placed in a number of vascular locations. For example, valve can be deployed and placed within a major vein of a patient's leg. In one embodiment, major veins include, but are not limited to, those of the peripheral venous system. Examples of veins in the peripheral venous system include, but are not limited to, the superficial veins such as the short saphenous vein and the greater saphenous vein, and the veins of the deep venous system, such as the popliteal vein and the femoral vein.
- As described herein, the valve can be deployed from the catheter in a number of ways. For example, the catheter can include the retractable sheath in which valve can be at least partially housed, as described herein. Valve can be deployed by retracting the retractable sheath of the catheter, where the valve self-expands to be positioned at the predetermined location. In an additional example, the catheter can include a deployment shaft and sheath in which valve can be at least partially housed adjacent the deployment shaft, as described herein. Valve can be deployed by moving the deployment shaft through the catheter to deploy valve from the sheath, where the valve self-expands to be positioned at the predetermined location. In an additional embodiment, the valve can be deployed through the use of an inflatable balloon.
- Once implanted, the valve can provide sufficient contact and expansion force against the body lumen wall to prevent retrograde flow between the valve and the body lumen wall. For example, the valve can be selected to have a larger expansion diameter than the diameter of the inner wall of the body lumen. This can then allow valve to exert a force on the body lumen wall and accommodate changes in the body lumen diameter, while maintaining the proper placement of valve. As described herein, the valve can engage the lumen so as to reduce the volume of retrograde flow through and around valve. It is, however, understood that some leaking or fluid flow may occur between the valve and the body lumen and/or through valve leaflets.
- In addition, the use of both the bulbous portion and/or elongate base portion of the valve can provide a self centering aspect to valve within a body lumen. In one embodiment, the self centering aspect resulting from the bulbous portion and/or elongate base portion of the valve may allow valve to maintain a substantially coaxial alignment with the body lumen (e.g., such as a vein) as valve leaflets deflect between the open and closed configurations so as to better seal the reversible opening when valve is closed.
- While the present disclosure has been shown and described in detail above, it will be clear to the person skilled in the art that changes and modifications may be made without departing from the scope of the disclosure. As such, that which is set forth in the foregoing description and accompanying drawings is offered by way of illustration only and not as a limitation. The actual scope of the disclosure is intended to be defined by the following claims, along with the full range of equivalents to which such claims are entitled.
- In addition, one of ordinary skill in the art will appreciate upon reading and understanding this disclosure that other variations for the disclosure described herein can be included within the scope of the present disclosure. For example, the
frame 102 and/or thevalve leaflets 104 can be coated with a non-thrombogenic biocompatible material, as are known or will be known. - In the foregoing Detailed Description, various features are grouped together in several embodiments for the purpose of streamlining the disclosure. This method of disclosure is not to be interpreted as reflecting an intention that the embodiments of the disclosure require more features than are expressly recited in each claim. Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed embodiment. Thus, the following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separate embodiment.
Claims (20)
1. A valve comprising:
a first member forming a first end and a second end of the valve;
a bulbous portion formed by bulbous portion members engaged to and extending outward from the first member;
wherein a diameter of the bulbous portion is greater than a diameter of the first member.
2. The valve of claim 1 , wherein the first member comprises circumferentially adjacent longitudinal segments, each longitudinal segment extending between the first end and the second end of the valve.
3. The valve of claim 2 , each bulbous portion member having a first end and a second end, wherein one bulbous portion member engages circumferentially adjacent longitudinal segments, the first end of the bulbous portion member being engaged to one longitudinal segment and the second end of the bulbous portion member being engaged to a circumferentially adjacent longitudinal segment.
4. The valve of claim 3 , wherein there are two bulbous portion members.
5. The valve of claim 2 , wherein the bulbous portion member has at least one turn.
6. The valve of claim 2 , the first member further comprising valve leaflet connection locations for valve leaflets.
7. The valve of claim 2 , further comprising leaflets, each leaflet comprising a free end, each leaflet engaged to two circumferentially adjacent longitudinal segments so that the free end extends between the two circumferentially adjacent longitudinal segments, the free end forming a part of a commissure for unidirectional flow through the valve.
8. The valve of claim 7 , wherein the commissure has a diameter less than the diameter of the bulbous portion.
9. The valve of claim 1 , wherein the first member forms two turns at the first end of the valve and two turns at the second end of the valve.
10. A valve comprising:
a frame comprising a first member defining a cross-sectional area having an outer perimeter, the first member comprising longitudinal segments, circumferentially adjacent longitudinal segments being symmetrical about a line parallel to a longitudinal axis of the valve; and
leaflets, each leaflet comprising a free end, each leaflet engaged to two circumferentially adjacent longitudinal segments so that the free end is positioned between first and second ends of the valve and extends between the two circumferentially adjacent longitudinal segments, the free end forming a part of a commissure for unidirectional flow through the valve.
11. The valve of claim 10 , the frame further comprising a second member engaged to the first member, the second member defining a cross-sectional area having an outer perimeter;
wherein the outer perimeter of the cross-sectional area defined by the second member is greater than the outer perimeter of the cross-sectional area defined by the first member.
12. The valve of claim 11 , further comprising a sinus pocket defined by the leaflets and the second member.
13. The valve of claim 10 , the cross-sectional area defined by the first member including:
a first cross-sectional area adjacent a first end of the valve, the first cross-sectional area having a first value; and
a second cross-sectional area adjacent a second end of the valve, the second cross-sectional area having a second value greater than the first value.
14. A valve comprising:
a frame comprising:
a first member, the first member forming a first zig-zag ring and a second zig-zag ring interconnected to one another; and
second members engaged to, extending outward from, the first zig-zag ring to form a bulbous portion, the bulbous portion defining a cross-sectional area having an outer perimeter that is greater than the an outer perimeter of a cross-sectional area defined by the first member.
15. The valve of claim 14 , further comprising leaflets, each leaflet engaged to and extending between the first and second zig-zag rings.
16. The valve of claim 14 , wherein the second members are engaged only to the first zig-zag ring.
17. The valve of claim 14 , wherein the second members are engaged to the first zig-zag ring and the second zig-zag ring.
18. The valve of claim 14 , the first member further forming connecting segments extending between and interconnecting the first and second zig-zag rings.
19. The valve of claim 18 , wherein the second members are engaged to the first zig-zag ring and the connecting segments.
20. The valve of claim 18 , wherein the connecting segments form a zig-zag ring.
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US14/877,182 US9474609B2 (en) | 2005-09-21 | 2015-10-07 | Venous valve, system, and method with sinus pocket |
US15/286,025 US10548734B2 (en) | 2005-09-21 | 2016-10-05 | Venous valve, system, and method with sinus pocket |
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US11/232,403 US7569071B2 (en) | 2005-09-21 | 2005-09-21 | Venous valve, system, and method with sinus pocket |
US12/509,604 US7951189B2 (en) | 2005-09-21 | 2009-07-27 | Venous valve, system, and method with sinus pocket |
US13/117,770 US8460365B2 (en) | 2005-09-21 | 2011-05-27 | Venous valve, system, and method with sinus pocket |
US13/913,830 US20130274865A1 (en) | 2005-09-21 | 2013-06-10 | Venous Valve, System, and Method With Sinus Pocket |
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US11/652,299 Abandoned US20070129788A1 (en) | 2005-09-21 | 2007-01-11 | Venous valve with sinus |
US12/509,604 Active 2025-09-22 US7951189B2 (en) | 2005-09-21 | 2009-07-27 | Venous valve, system, and method with sinus pocket |
US13/117,770 Expired - Fee Related US8460365B2 (en) | 2005-09-21 | 2011-05-27 | Venous valve, system, and method with sinus pocket |
US13/454,778 Active US8672997B2 (en) | 2005-09-21 | 2012-04-24 | Valve with sinus |
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US14/877,182 Active US9474609B2 (en) | 2005-09-21 | 2015-10-07 | Venous valve, system, and method with sinus pocket |
US15/286,025 Expired - Fee Related US10548734B2 (en) | 2005-09-21 | 2016-10-05 | Venous valve, system, and method with sinus pocket |
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US12/509,604 Active 2025-09-22 US7951189B2 (en) | 2005-09-21 | 2009-07-27 | Venous valve, system, and method with sinus pocket |
US13/117,770 Expired - Fee Related US8460365B2 (en) | 2005-09-21 | 2011-05-27 | Venous valve, system, and method with sinus pocket |
US13/454,778 Active US8672997B2 (en) | 2005-09-21 | 2012-04-24 | Valve with sinus |
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US15/286,025 Expired - Fee Related US10548734B2 (en) | 2005-09-21 | 2016-10-05 | Venous valve, system, and method with sinus pocket |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9987133B2 (en) | 2008-02-26 | 2018-06-05 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US10492910B2 (en) | 2015-10-13 | 2019-12-03 | Venarum Medical, Llc | Implantable valve and method |
US11065138B2 (en) | 2016-05-13 | 2021-07-20 | Jenavalve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
US11185405B2 (en) | 2013-08-30 | 2021-11-30 | Jenavalve Technology, Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
US11337800B2 (en) | 2015-05-01 | 2022-05-24 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
US11357624B2 (en) | 2007-04-13 | 2022-06-14 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
US11517431B2 (en) | 2005-01-20 | 2022-12-06 | Jenavalve Technology, Inc. | Catheter system for implantation of prosthetic heart valves |
US11564794B2 (en) | 2008-02-26 | 2023-01-31 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US11589981B2 (en) | 2010-05-25 | 2023-02-28 | Jenavalve Technology, Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
Families Citing this family (142)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9498604B2 (en) | 1997-11-12 | 2016-11-22 | Genesis Technologies Llc | Medical device and method |
AU2003277115A1 (en) * | 2002-10-01 | 2004-04-23 | Ample Medical, Inc. | Device and method for repairing a native heart valve leaflet |
US20050137687A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical | Heart valve anchor and method |
US7959666B2 (en) | 2003-12-23 | 2011-06-14 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
ITTO20040135A1 (en) * | 2004-03-03 | 2004-06-03 | Sorin Biomedica Cardio Spa | CARDIAC VALVE PROSTHESIS |
AU2005221234C1 (en) | 2004-03-11 | 2009-10-29 | Percutaneous Cardiovascular Solutions Pty Limited | Percutaneous heart valve prosthesis |
US7744642B2 (en) * | 2004-11-19 | 2010-06-29 | Biomedical Research Associates, Inc. | Prosthetic venous valves |
ITTO20050074A1 (en) | 2005-02-10 | 2006-08-11 | Sorin Biomedica Cardio Srl | CARDIAC VALVE PROSTHESIS |
US7914569B2 (en) | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
US20060259115A1 (en) * | 2005-05-13 | 2006-11-16 | Case Brian C | Medical device delivery systems that facilitate medical device placement in the presence of ultrasonic waves |
US8043352B2 (en) * | 2005-05-24 | 2011-10-25 | Cook Medical Technologies Llc | Medical device delivery system with captive inner member |
WO2007058857A2 (en) | 2005-11-10 | 2007-05-24 | Arshad Quadri | Balloon-expandable, self-expanding, vascular prosthesis connecting stent |
US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US7947074B2 (en) * | 2005-12-23 | 2011-05-24 | Attila Meretei | Implantable prosthetic valve |
US20070167745A1 (en) * | 2005-12-29 | 2007-07-19 | Cook Incorporated | Methods for delivering medical devices to a target implant site within a body vessel |
US8403977B2 (en) | 2006-05-04 | 2013-03-26 | Cook Medical Technologies Llc | Self-orienting delivery system |
EP2478872B1 (en) * | 2006-05-30 | 2018-07-04 | Cook Medical Technologies LLC | Artificial valve prosthesis |
WO2008089365A2 (en) * | 2007-01-19 | 2008-07-24 | The Cleveland Clinic Foundation | Method for implanting a cardiovascular valve |
US9415567B2 (en) * | 2007-02-05 | 2016-08-16 | Boston Scientific Scimed, Inc. | Synthetic composite structures |
WO2008097589A1 (en) | 2007-02-05 | 2008-08-14 | Boston Scientific Limited | Percutaneous valve, system, and method |
US20080208328A1 (en) * | 2007-02-23 | 2008-08-28 | Endovalve, Inc. | Systems and Methods For Placement of Valve Prosthesis System |
US20080208327A1 (en) * | 2007-02-27 | 2008-08-28 | Rowe Stanton J | Method and apparatus for replacing a prosthetic valve |
US9848981B2 (en) | 2007-10-12 | 2017-12-26 | Mayo Foundation For Medical Education And Research | Expandable valve prosthesis with sealing mechanism |
US20090105813A1 (en) * | 2007-10-17 | 2009-04-23 | Sean Chambers | Implantable valve device |
WO2009067432A1 (en) * | 2007-11-19 | 2009-05-28 | Cook Incorporated | Valve frame |
US8057532B2 (en) * | 2007-11-28 | 2011-11-15 | Cook Medical Technologies Llc | Implantable frame and valve design |
US7972378B2 (en) | 2008-01-24 | 2011-07-05 | Medtronic, Inc. | Stents for prosthetic heart valves |
US8157852B2 (en) | 2008-01-24 | 2012-04-17 | Medtronic, Inc. | Delivery systems and methods of implantation for prosthetic heart valves |
US20090248142A1 (en) | 2008-03-25 | 2009-10-01 | Medtronic Vascular, Inc. | Methods, Devices and Systems for Treating Venous Insufficiency |
US8840661B2 (en) | 2008-05-16 | 2014-09-23 | Sorin Group Italia S.R.L. | Atraumatic prosthetic heart valve prosthesis |
WO2010011878A2 (en) * | 2008-07-24 | 2010-01-28 | Cook Incorporated | Valve device with biased leaflets |
EP3753534A1 (en) | 2008-09-29 | 2020-12-23 | Edwards Lifesciences CardiAQ LLC | Heart valve |
EP2341871B1 (en) | 2008-10-01 | 2017-03-22 | Edwards Lifesciences CardiAQ LLC | Delivery system for vascular implant |
ES2551694T3 (en) | 2008-12-23 | 2015-11-23 | Sorin Group Italia S.R.L. | Expandable prosthetic valve with anchoring appendages |
US8109990B2 (en) * | 2009-02-24 | 2012-02-07 | Cook Medical Technologies Llc | Low profile support frame and related intraluminal medical devices |
US8348997B2 (en) * | 2009-02-24 | 2013-01-08 | Medtronic Vascular, Inc. | One-way replacement valve |
GB0905444D0 (en) * | 2009-03-30 | 2009-05-13 | Ucl Business Plc | Heart valve prosthesis |
CA2961053C (en) | 2009-04-15 | 2019-04-30 | Edwards Lifesciences Cardiaq Llc | Vascular implant and delivery system |
EP2628465A1 (en) | 2009-04-27 | 2013-08-21 | Sorin Group Italia S.r.l. | Prosthetic vascular conduit |
US20110033933A1 (en) * | 2009-07-15 | 2011-02-10 | Morteza Gharib | Method applying hemodynamic forcing and klf2 to initiate the growth and development of cardiac valves |
WO2011019892A2 (en) * | 2009-08-14 | 2011-02-17 | Mayo Foundation For Medical Education And Research | Non-circular esophageal stents and delivery systems |
US8652203B2 (en) | 2010-09-23 | 2014-02-18 | Cardiaq Valve Technologies, Inc. | Replacement heart valves, delivery devices and methods |
US8808369B2 (en) | 2009-10-05 | 2014-08-19 | Mayo Foundation For Medical Education And Research | Minimally invasive aortic valve replacement |
US8449599B2 (en) | 2009-12-04 | 2013-05-28 | Edwards Lifesciences Corporation | Prosthetic valve for replacing mitral valve |
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
US20110224785A1 (en) | 2010-03-10 | 2011-09-15 | Hacohen Gil | Prosthetic mitral valve with tissue anchors |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
IT1400327B1 (en) | 2010-05-21 | 2013-05-24 | Sorin Biomedica Cardio Srl | SUPPORT DEVICE FOR VALVULAR PROSTHESIS AND CORRESPONDING CORRESPONDENT. |
US9763657B2 (en) | 2010-07-21 | 2017-09-19 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
US9561094B2 (en) | 2010-07-23 | 2017-02-07 | Nfinium Vascular Technologies, Llc | Devices and methods for treating venous diseases |
US20120130468A1 (en) | 2010-07-27 | 2012-05-24 | Fred Khosravi | Methods and apparatus for treating neurovascular venous outflow obstruction |
EP2629699B1 (en) * | 2010-10-21 | 2017-01-04 | Medtronic, Inc. | Mitral bioprosthesis with low ventricular profile |
EP2486893B1 (en) | 2011-02-14 | 2017-07-05 | Sorin Group Italia S.r.l. | Sutureless anchoring device for cardiac valve prostheses |
EP2486894B1 (en) | 2011-02-14 | 2021-06-09 | Sorin Group Italia S.r.l. | Sutureless anchoring device for cardiac valve prostheses |
WO2012127309A1 (en) | 2011-03-21 | 2012-09-27 | Ontorfano Matteo | Disk-based valve apparatus and method for the treatment of valve dysfunction |
US9744033B2 (en) | 2011-04-01 | 2017-08-29 | W.L. Gore & Associates, Inc. | Elastomeric leaflet for prosthetic heart valves |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
CN104039271B (en) * | 2011-07-29 | 2016-09-07 | 卡内基梅隆大学 | Artificial valve conduit and production method thereof for cardiac reconstruction operation |
EP3417813B1 (en) | 2011-08-05 | 2020-05-13 | Cardiovalve Ltd | Percutaneous mitral valve replacement |
WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US8852272B2 (en) | 2011-08-05 | 2014-10-07 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US20140324164A1 (en) | 2011-08-05 | 2014-10-30 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
US9554806B2 (en) | 2011-09-16 | 2017-01-31 | W. L. Gore & Associates, Inc. | Occlusive devices |
EP2842517A1 (en) | 2011-12-29 | 2015-03-04 | Sorin Group Italia S.r.l. | A kit for implanting prosthetic vascular conduits |
US10940167B2 (en) | 2012-02-10 | 2021-03-09 | Cvdevices, Llc | Methods and uses of biological tissues for various stent and other medical applications |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
EP2858711B1 (en) | 2012-06-06 | 2018-03-07 | Magenta Medical Ltd. | Prosthetic renal valve |
US9883941B2 (en) | 2012-06-19 | 2018-02-06 | Boston Scientific Scimed, Inc. | Replacement heart valve |
WO2014015212A1 (en) | 2012-07-20 | 2014-01-23 | Cook Medical Technologies Llc | Implantable medical device having a sleeve |
US20150351906A1 (en) | 2013-01-24 | 2015-12-10 | Mitraltech Ltd. | Ventricularly-anchored prosthetic valves |
AU2014214700B2 (en) | 2013-02-11 | 2018-01-18 | Cook Medical Technologies Llc | Expandable support frame and medical device |
AU2014225445B2 (en) | 2013-03-08 | 2018-09-20 | Carnegie Mellon University | Expandable implantable conduit |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US10583231B2 (en) | 2013-03-13 | 2020-03-10 | Magenta Medical Ltd. | Blood pump |
EP3459498B1 (en) * | 2013-03-13 | 2020-04-01 | W. L. Gore & Associates Inc | Prosthetic heart valve comprising durable high strength polymer composites suitable for implant |
EP3656293B1 (en) | 2013-03-13 | 2021-08-25 | Magenta Medical Ltd. | Blood pump and blood-impermeable sleeve |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
US9681186B2 (en) | 2013-06-11 | 2017-06-13 | Nokia Technologies Oy | Method, apparatus and computer program product for gathering and presenting emotional response to an event |
US11911258B2 (en) | 2013-06-26 | 2024-02-27 | W. L. Gore & Associates, Inc. | Space filling devices |
US9561103B2 (en) | 2013-07-17 | 2017-02-07 | Cephea Valve Technologies, Inc. | System and method for cardiac valve repair and replacement |
US9764113B2 (en) | 2013-12-11 | 2017-09-19 | Magenta Medical Ltd | Curved catheter |
US20170189175A1 (en) | 2014-05-07 | 2017-07-06 | Baylor College Of Medicine | Artificial, flexible valves and methods of fabricating and serially expanding the same |
EP3151904A4 (en) | 2014-06-04 | 2018-02-14 | Nfinium Vascular Technologies, LLC | Low radial force vascular device and method of occlusion |
MX2017000303A (en) | 2014-07-08 | 2017-07-10 | Avinger Inc | High speed chronic total occlusion crossing devices. |
EP4066786A1 (en) | 2014-07-30 | 2022-10-05 | Cardiovalve Ltd. | Articulatable prosthetic valve |
US10143544B2 (en) | 2014-08-29 | 2018-12-04 | Cook Medical Technologies Llc | Low profile intraluminal medical devices |
US10010399B2 (en) | 2014-08-29 | 2018-07-03 | Cook Medical Technologies Llc | Low profile intraluminal filters |
WO2016093877A1 (en) | 2014-12-09 | 2016-06-16 | Cephea Valve Technologies, Inc. | Replacement cardiac valves and methods of use and manufacture |
WO2016125160A1 (en) | 2015-02-05 | 2016-08-11 | Mitraltech Ltd. | Prosthetic valve with axially-sliding frames |
US9974651B2 (en) | 2015-02-05 | 2018-05-22 | Mitral Tech Ltd. | Prosthetic valve with axially-sliding frames |
CN107405152B (en) | 2015-02-10 | 2021-04-09 | 波士顿科学国际有限公司 | Vascular occlusion device |
CN107427303A (en) | 2015-02-18 | 2017-12-01 | 波士顿科学国际有限公司 | Vasoocclusive device |
WO2018136959A1 (en) | 2017-01-23 | 2018-07-26 | Cephea Valve Technologies, Inc. | Replacement mitral valves |
EP3294221B1 (en) | 2015-05-14 | 2024-03-06 | Cephea Valve Technologies, Inc. | Replacement mitral valves |
ES2908460T3 (en) | 2015-05-14 | 2022-04-29 | Gore & Ass | Devices for occlusion of an atrial appendage |
EP3294220B1 (en) | 2015-05-14 | 2023-12-06 | Cephea Valve Technologies, Inc. | Cardiac valve delivery devices and systems |
US11291824B2 (en) | 2015-05-18 | 2022-04-05 | Magenta Medical Ltd. | Blood pump |
US10143554B2 (en) | 2015-12-03 | 2018-12-04 | Medtronic Vascular, Inc. | Venous valve prostheses |
US10299916B2 (en) * | 2016-01-07 | 2019-05-28 | Medtronic Vascular, Inc. | Bioprosthetic tissue repair and reinforcement |
CA3007670A1 (en) | 2016-01-29 | 2017-08-03 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
WO2017151900A1 (en) | 2016-03-02 | 2017-09-08 | Peca Labs, Inc. | Expandable implantable conduit |
US11331187B2 (en) | 2016-06-17 | 2022-05-17 | Cephea Valve Technologies, Inc. | Cardiac valve delivery devices and systems |
US10098740B2 (en) | 2016-07-15 | 2018-10-16 | Covidien Lp | Venous valve prostheses |
US10350062B2 (en) | 2016-07-21 | 2019-07-16 | Edwards Lifesciences Corporation | Replacement heart valve prosthesis |
EP3848003A1 (en) | 2016-08-10 | 2021-07-14 | Cardiovalve Ltd. | Prosthetic valve with concentric frames |
USD800908S1 (en) | 2016-08-10 | 2017-10-24 | Mitraltech Ltd. | Prosthetic valve element |
WO2018061002A1 (en) | 2016-09-29 | 2018-04-05 | Magenta Medical Ltd. | Blood vessel tube |
WO2018071417A1 (en) | 2016-10-10 | 2018-04-19 | Peca Labs, Inc. | Transcatheter stent and valve assembly |
CA3039285A1 (en) | 2016-10-25 | 2018-05-03 | Magenta Medical Ltd. | Ventricular assist device |
WO2018090148A1 (en) | 2016-11-21 | 2018-05-24 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
WO2018096531A1 (en) | 2016-11-23 | 2018-05-31 | Magenta Medical Ltd. | Blood pumps |
AU2018203053B2 (en) | 2017-01-23 | 2020-03-05 | Cephea Valve Technologies, Inc. | Replacement mitral valves |
EP3403615A1 (en) * | 2017-05-17 | 2018-11-21 | Aorticlab Sarl | Transcatheter valve prosthesis for blood vessel |
US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
US11246704B2 (en) | 2017-08-03 | 2022-02-15 | Cardiovalve Ltd. | Prosthetic heart valve |
US10575948B2 (en) | 2017-08-03 | 2020-03-03 | Cardiovalve Ltd. | Prosthetic heart valve |
US10537426B2 (en) | 2017-08-03 | 2020-01-21 | Cardiovalve Ltd. | Prosthetic heart valve |
US10888421B2 (en) | 2017-09-19 | 2021-01-12 | Cardiovalve Ltd. | Prosthetic heart valve with pouch |
US10350095B2 (en) * | 2017-08-17 | 2019-07-16 | Incubar, LLC | Prosthetic vascular valve and methods associated therewith |
CA3073834A1 (en) | 2017-08-25 | 2019-02-28 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US11173023B2 (en) | 2017-10-16 | 2021-11-16 | W. L. Gore & Associates, Inc. | Medical devices and anchors therefor |
GB201720803D0 (en) | 2017-12-13 | 2018-01-24 | Mitraltech Ltd | Prosthetic Valve and delivery tool therefor |
US10905808B2 (en) | 2018-01-10 | 2021-02-02 | Magenta Medical Ltd. | Drive cable for use with a blood pump |
EP3689388B1 (en) | 2018-01-10 | 2022-04-06 | Magenta Medical Ltd. | Ventricular assist device |
GB201800399D0 (en) | 2018-01-10 | 2018-02-21 | Mitraltech Ltd | Temperature-control during crimping of an implant |
EP3720390B1 (en) | 2018-01-25 | 2024-05-01 | Edwards Lifesciences Corporation | Delivery system for aided replacement valve recapture and repositioning post- deployment |
WO2019191111A1 (en) * | 2018-03-26 | 2019-10-03 | The Trustees Of The University Of Pennsylvania | Systems and methods for multilane vasculature |
US10893927B2 (en) | 2018-03-29 | 2021-01-19 | Magenta Medical Ltd. | Inferior vena cava blood-flow implant |
WO2019224577A1 (en) * | 2018-05-23 | 2019-11-28 | Sorin Group Italia S.R.L. | A cardiac valve prosthesis |
US11883232B2 (en) * | 2018-09-11 | 2024-01-30 | Olympus Medical Systems Corporation | Radial ultrasound capsule and system |
EP3876870B1 (en) | 2018-11-08 | 2023-12-20 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
EP3782667B1 (en) | 2019-01-24 | 2022-04-06 | Magenta Medical Ltd. | Impeller and frame of a blood pump |
CA3135753C (en) | 2019-04-01 | 2023-10-24 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
US11491006B2 (en) | 2019-04-10 | 2022-11-08 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
AU2020279750B2 (en) | 2019-05-20 | 2023-07-13 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
EP3986332A4 (en) | 2019-06-20 | 2023-07-19 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
WO2021209334A1 (en) | 2020-04-17 | 2021-10-21 | Cortronik GmbH | Venous valve prosthesis |
WO2022048585A1 (en) * | 2020-09-04 | 2022-03-10 | 杭州诺谊医疗科技有限公司 | Interventional venous valve stent and venous valve prosthesis |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040186563A1 (en) * | 2003-03-18 | 2004-09-23 | Lobbi Mario M. | Minimally-invasive heart valve with cusp positioners |
US20040260389A1 (en) * | 2003-04-24 | 2004-12-23 | Cook Incorporated | Artificial valve prosthesis with improved flow dynamics |
US7429269B2 (en) * | 2003-07-08 | 2008-09-30 | Ventor Technologies Ltd. | Aortic prosthetic devices |
Family Cites Families (627)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US690848A (en) * | 1900-12-13 | 1902-01-07 | John C Fleming | Toilet cream. |
US3029819A (en) | 1959-07-30 | 1962-04-17 | J L Mcatee | Artery graft and method of producing artery grafts |
US3221006A (en) | 1962-11-13 | 1965-11-30 | Eastman Kodak Co | 5-amino-3-substituted-1,2,4-thiadiazole azo compounds |
US3365728A (en) | 1964-12-18 | 1968-01-30 | Edwards Lab Inc | Upholstered heart valve having a sealing ring adapted for dispensing medicaments |
US3671979A (en) | 1969-09-23 | 1972-06-27 | Univ Utah | Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve |
US3725961A (en) | 1970-12-29 | 1973-04-10 | Baxter Laboratories Inc | Prosthetic heart valve having fabric suturing element |
US4291420A (en) | 1973-11-09 | 1981-09-29 | Medac Gesellschaft Fur Klinische Spezialpraparate Mbh | Artificial heart valve |
US3983581A (en) | 1975-01-20 | 1976-10-05 | William W. Angell | Heart valve stent |
US4084268A (en) | 1976-04-22 | 1978-04-18 | Shiley Laboratories, Incorporated | Prosthetic tissue heart valve |
US4222126A (en) * | 1978-12-14 | 1980-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare | Unitized three leaflet heart valve |
US7018407B1 (en) | 1981-10-29 | 2006-03-28 | Medtronic | Valve holder for tricuspid heart valve |
US5275622A (en) | 1983-12-09 | 1994-01-04 | Harrison Medical Technologies, Inc. | Endovascular grafting apparatus, system and method and devices for use therewith |
DE3426300A1 (en) | 1984-07-17 | 1986-01-30 | Doguhan Dr.med. 6000 Frankfurt Baykut | TWO-WAY VALVE AND ITS USE AS A HEART VALVE PROSTHESIS |
US4935030A (en) | 1985-06-17 | 1990-06-19 | Medtronic, Inc. | Mechanical heart valve prosthesis |
WO1988000459A1 (en) | 1986-07-17 | 1988-01-28 | Quotidian No. 100 Pty. Limited | Prosthetic venous valve |
US4872874A (en) | 1987-05-29 | 1989-10-10 | Taheri Syde A | Method and apparatus for transarterial aortic graft insertion and implantation |
JPS6483251A (en) | 1987-09-24 | 1989-03-29 | Terumo Corp | Instrument for securing inner diameter of cavity of tubular organ |
IT1218947B (en) | 1988-01-12 | 1990-04-24 | Sorin Biomedica Spa | CARDIAC VALVE PROSTHESIS |
SE8800244D0 (en) | 1988-01-27 | 1988-01-27 | Medical Innovation Ab | DEVICE FOR CUTTING OF LEFT FLAVORS |
US5425739A (en) | 1989-03-09 | 1995-06-20 | Avatar Design And Development, Inc. | Anastomosis stent and stent selection system |
US4994077A (en) | 1989-04-21 | 1991-02-19 | Dobben Richard L | Artificial heart valve for implantation in a blood vessel |
WO1990014804A1 (en) | 1989-05-31 | 1990-12-13 | Baxter International Inc. | Biological valvular prosthesis |
US5609626A (en) | 1989-05-31 | 1997-03-11 | Baxter International Inc. | Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts |
CA2033195C (en) | 1989-06-19 | 1994-11-15 | Hugh H. Trout, Iii | Aortic graft and method for repairing aneurysm |
US5290300A (en) | 1989-07-31 | 1994-03-01 | Baxter International Inc. | Flexible suture guide and holder |
US5411552A (en) | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
GB9012716D0 (en) * | 1990-06-07 | 1990-08-01 | Frater Robert W M | Mitral heart valve replacements |
US5578071A (en) | 1990-06-11 | 1996-11-26 | Parodi; Juan C. | Aortic graft |
US5122154A (en) | 1990-08-15 | 1992-06-16 | Rhodes Valentine J | Endovascular bypass graft |
ES1015196Y (en) | 1990-09-21 | 1992-01-01 | Rosello Barbara Mariano | SURGICAL INSTRUMENT. |
AR246020A1 (en) | 1990-10-03 | 1994-03-30 | Hector Daniel Barone Juan Carl | A ball device for implanting an intraluminous aortic prosthesis, for repairing aneurysms. |
US5282847A (en) | 1991-02-28 | 1994-02-01 | Medtronic, Inc. | Prosthetic vascular grafts with a pleated structure |
US5272909A (en) | 1991-04-25 | 1993-12-28 | Baxter International Inc. | Method and device for testing venous valves |
IT1245750B (en) | 1991-05-24 | 1994-10-14 | Sorin Biomedica Emodialisi S R | CARDIAC VALVE PROSTHESIS, PARTICULARLY FOR REPLACING THE AORTIC VALVE |
US5370685A (en) | 1991-07-16 | 1994-12-06 | Stanford Surgical Technologies, Inc. | Endovascular aortic valve replacement |
US5441552A (en) | 1991-11-27 | 1995-08-15 | Delillo; Joseph | Method and apparatus for composting solid waste and sludge |
US5489297A (en) | 1992-01-27 | 1996-02-06 | Duran; Carlos M. G. | Bioprosthetic heart valve with absorbable stent |
US5163953A (en) | 1992-02-10 | 1992-11-17 | Vince Dennis J | Toroidal artificial heart valve stent |
US5258023A (en) | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
US5683448A (en) | 1992-02-21 | 1997-11-04 | Boston Scientific Technology, Inc. | Intraluminal stent and graft |
US5234448A (en) | 1992-02-28 | 1993-08-10 | Shadyside Hospital | Method and apparatus for connecting and closing severed blood vessels |
US5332402A (en) | 1992-05-12 | 1994-07-26 | Teitelbaum George P | Percutaneously-inserted cardiac valve |
FR2693366B1 (en) | 1992-07-09 | 1994-09-02 | Celsa Lg | Device forming a vascular prosthesis usable for the treatment of aneurysms. |
US5982645A (en) | 1992-08-25 | 1999-11-09 | Square D Company | Power conversion and distribution system |
EP0604022A1 (en) | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method for its manufacture |
US6010531A (en) | 1993-02-22 | 2000-01-04 | Heartport, Inc. | Less-invasive devices and methods for cardiac valve surgery |
US5972030A (en) | 1993-02-22 | 1999-10-26 | Heartport, Inc. | Less-invasive devices and methods for treatment of cardiac valves |
US5480423A (en) | 1993-05-20 | 1996-01-02 | Boston Scientific Corporation | Prosthesis delivery |
WO1995008966A1 (en) | 1993-09-30 | 1995-04-06 | White Geoffrey H | Intraluminal graft |
US5713950A (en) | 1993-11-01 | 1998-02-03 | Cox; James L. | Method of replacing heart valves using flexible tubes |
WO1995013033A1 (en) | 1993-11-08 | 1995-05-18 | Lazarus Harrison M | Intraluminal vascular graft and method |
DE4401227C2 (en) | 1994-01-18 | 1999-03-18 | Ernst Peter Prof Dr M Strecker | Endoprosthesis implantable percutaneously in a patient's body |
FR2718951B1 (en) | 1994-04-26 | 1996-07-26 | Perouse Implant Laboratoire | Tubular stent. |
CA2149290C (en) | 1994-05-26 | 2006-07-18 | Carl T. Urban | Optical trocar |
US5522881A (en) | 1994-06-28 | 1996-06-04 | Meadox Medicals, Inc. | Implantable tubular prosthesis having integral cuffs |
US5554185A (en) | 1994-07-18 | 1996-09-10 | Block; Peter C. | Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same |
EP0804255B1 (en) * | 1994-07-29 | 2001-10-04 | Edwards Lifesciences Corporation | Methods for treating implantable biological tissues to mitigate the calcification thereof |
FR2728457B1 (en) | 1994-12-21 | 1997-03-21 | Franceschi Claude | ARTIFICIAL VALVE FOR BLOOD VESSEL |
US5681345A (en) | 1995-03-01 | 1997-10-28 | Scimed Life Systems, Inc. | Sleeve carrying stent |
BE1009278A3 (en) | 1995-04-12 | 1997-01-07 | Corvita Europ | Guardian self-expandable medical device introduced in cavite body, and medical device with a stake as. |
AU6105596A (en) | 1995-06-07 | 1996-12-30 | St. Jude Medical Inc. | Prosthetic heart valve with increased lumen |
EP0830113A1 (en) | 1995-06-07 | 1998-03-25 | St.Jude Medical, Inc | Direct suture orifice for mechanical heart valve |
US5769882A (en) | 1995-09-08 | 1998-06-23 | Medtronic, Inc. | Methods and apparatus for conformably sealing prostheses within body lumens |
US6193745B1 (en) | 1995-10-03 | 2001-02-27 | Medtronic, Inc. | Modular intraluminal prosteheses construction and methods |
US5824037A (en) | 1995-10-03 | 1998-10-20 | Medtronic, Inc. | Modular intraluminal prostheses construction and methods |
US6402780B2 (en) | 1996-02-23 | 2002-06-11 | Cardiovascular Technologies, L.L.C. | Means and method of replacing a heart valve in a minimally invasive manner |
US5716370A (en) | 1996-02-23 | 1998-02-10 | Williamson, Iv; Warren | Means for replacing a heart valve in a minimally invasive manner |
US6273912B1 (en) | 1996-02-28 | 2001-08-14 | Impra, Inc. | Flanged graft for end-to-side anastomosis |
US5928916A (en) | 1996-04-25 | 1999-07-27 | Medtronic, Inc. | Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces |
ATE288233T1 (en) | 1996-06-20 | 2005-02-15 | Vascutek Ltd | REPAIR OF BODY VESSELS USING PROSTHESES |
US5843161A (en) | 1996-06-26 | 1998-12-01 | Cordis Corporation | Endoprosthesis assembly for percutaneous deployment and method of deploying same |
US5741326A (en) | 1996-07-15 | 1998-04-21 | Cordis Corporation | Low profile thermally set wrapped cover for a percutaneously deployed stent |
AU3733497A (en) | 1996-07-19 | 1998-02-10 | Regents Of The University Of Minnesota | Recombinant sef14 fimbrial protein from salmonella |
US6764509B2 (en) | 1996-09-06 | 2004-07-20 | Carbomedics Inc. | Prosthetic heart valve with surface modification |
US5895419A (en) | 1996-09-30 | 1999-04-20 | St. Jude Medical, Inc. | Coated prosthetic cardiac device |
NL1004827C2 (en) * | 1996-12-18 | 1998-06-19 | Surgical Innovations Vof | Device for regulating blood circulation. |
US6206911B1 (en) | 1996-12-19 | 2001-03-27 | Simcha Milo | Stent combination |
US6015431A (en) | 1996-12-23 | 2000-01-18 | Prograft Medical, Inc. | Endolumenal stent-graft with leak-resistant seal |
US5879320A (en) | 1996-12-23 | 1999-03-09 | Cazenave; Craig Richard | Implantable vascular device |
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
US5735859A (en) | 1997-02-14 | 1998-04-07 | Cathco, Inc. | Distally attachable and releasable sheath for a stent delivery system |
US6692912B1 (en) * | 1997-03-05 | 2004-02-17 | Matrix Technologies Corporation | Nucleic acid-containing polymerizable complex |
ATE287679T1 (en) | 1997-03-05 | 2005-02-15 | Boston Scient Ltd | COMPLIANT MULTI-LAYER STENT DEVICE |
US5928281A (en) | 1997-03-27 | 1999-07-27 | Baxter International Inc. | Tissue heart valves |
US5961549A (en) * | 1997-04-03 | 1999-10-05 | Baxter International Inc. | Multi-leaflet bioprosthetic heart valve |
WO1998046115A2 (en) | 1997-04-11 | 1998-10-22 | Transvascular, Inc. | Methods and apparatus for transmyocardial direct coronary revascularization |
US6007575A (en) | 1997-06-06 | 1999-12-28 | Samuels; Shaun Laurence Wilkie | Inflatable intraluminal stent and method for affixing same within the human body |
US6635080B1 (en) | 1997-06-19 | 2003-10-21 | Vascutek Limited | Prosthesis for repair of body passages |
ES2335252T3 (en) | 1997-06-27 | 2010-03-23 | The Trustees Of Columbia University In The City Of New York | APPARATUS FOR THE REPAIR OF VALVES OF THE CIRCULATORY SYSTEM. |
DE19731834A1 (en) | 1997-07-24 | 1999-06-17 | Ernst Peter Prof Dr M Strecker | Implantation device |
US6306164B1 (en) | 1997-09-05 | 2001-10-23 | C. R. Bard, Inc. | Short body endoprosthesis |
FR2768324B1 (en) | 1997-09-12 | 1999-12-10 | Jacques Seguin | SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER |
US5910170A (en) | 1997-12-17 | 1999-06-08 | St. Jude Medical, Inc. | Prosthetic heart valve stent utilizing mounting clips |
ATE449581T1 (en) | 1997-12-29 | 2009-12-15 | The Cleveland Clinic Foundation | SYSTEM FOR THE MINIMALLY INVASIVE INTRODUCTION OF A HEART VALVE BIOPROSTHESIS |
US6530952B2 (en) | 1997-12-29 | 2003-03-11 | The Cleveland Clinic Foundation | Bioprosthetic cardiovascular valve system |
US6656215B1 (en) | 2000-11-16 | 2003-12-02 | Cordis Corporation | Stent graft having an improved means for attaching a stent to a graft |
EP1067883A1 (en) | 1998-04-02 | 2001-01-17 | Salviac Limited | An implant comprising a support structure and a transition material made of porous plastics material |
US6074418A (en) | 1998-04-20 | 2000-06-13 | St. Jude Medical, Inc. | Driver tool for heart valve prosthesis fasteners |
US7452371B2 (en) * | 1999-06-02 | 2008-11-18 | Cook Incorporated | Implantable vascular device |
JP4399585B2 (en) | 1998-06-02 | 2010-01-20 | クック インコーポレイティド | Multi-sided medical device |
US6250308B1 (en) | 1998-06-16 | 2001-06-26 | Cardiac Concepts, Inc. | Mitral valve annuloplasty ring and method of implanting |
US6165183A (en) | 1998-07-15 | 2000-12-26 | St. Jude Medical, Inc. | Mitral and tricuspid valve repair |
US6641610B2 (en) | 1998-09-10 | 2003-11-04 | Percardia, Inc. | Valve designs for left ventricular conduits |
US6254564B1 (en) | 1998-09-10 | 2001-07-03 | Percardia, Inc. | Left ventricular conduit with blood vessel graft |
US6921811B2 (en) | 1998-09-22 | 2005-07-26 | Biosurface Engineering Technologies, Inc. | Bioactive coating composition and methods |
US6355030B1 (en) | 1998-09-25 | 2002-03-12 | Cardiothoracic Systems, Inc. | Instruments and methods employing thermal energy for the repair and replacement of cardiac valves |
US6051014A (en) | 1998-10-13 | 2000-04-18 | Embol-X, Inc. | Percutaneous filtration catheter for valve repair surgery and methods of use |
US6540780B1 (en) | 1998-11-23 | 2003-04-01 | Medtronic, Inc. | Porous synthetic vascular grafts with oriented ingrowth channels |
EP1144594A1 (en) * | 1998-11-24 | 2001-10-17 | Regents Of The University Of Minnesota | Transgenic circulating endothelial cells |
US20040267349A1 (en) | 2003-06-27 | 2004-12-30 | Kobi Richter | Amorphous metal alloy medical devices |
WO2000042951A1 (en) * | 1999-01-26 | 2000-07-27 | Edwards Lifesciences Corporation | Anatomical orifice sizers and methods of orifice sizing |
US6736845B2 (en) | 1999-01-26 | 2004-05-18 | Edwards Lifesciences Corporation | Holder for flexible heart valve |
US6896690B1 (en) | 2000-01-27 | 2005-05-24 | Viacor, Inc. | Cardiac valve procedure methods and devices |
US6364905B1 (en) | 1999-01-27 | 2002-04-02 | Sulzer Carbomedics Inc. | Tri-composite, full root, stentless valve |
DE19904975A1 (en) | 1999-02-06 | 2000-09-14 | Impella Cardiotech Ag | Device for intravascular heart valve surgery |
US6425916B1 (en) | 1999-02-10 | 2002-07-30 | Michi E. Garrison | Methods and devices for implanting cardiac valves |
US6666886B1 (en) | 1999-02-16 | 2003-12-23 | Regents Of The University Of Minnesota | Tissue equivalent approach to a tissue-engineered cardiovascular valve |
US6110201A (en) | 1999-02-18 | 2000-08-29 | Venpro | Bifurcated biological pulmonary valved conduit |
US6139575A (en) | 1999-04-02 | 2000-10-31 | Medtronic, Inc. | Hybrid mechanical heart valve prosthesis |
US7226467B2 (en) * | 1999-04-09 | 2007-06-05 | Evalve, Inc. | Fixation device delivery catheter, systems and methods of use |
US20040044350A1 (en) * | 1999-04-09 | 2004-03-04 | Evalve, Inc. | Steerable access sheath and methods of use |
EP2078498B1 (en) * | 1999-04-09 | 2010-12-22 | Evalve, Inc. | Apparatus for cardiac valve repair |
US6752813B2 (en) | 1999-04-09 | 2004-06-22 | Evalve, Inc. | Methods and devices for capturing and fixing leaflets in valve repair |
US6666885B2 (en) | 1999-04-16 | 2003-12-23 | Carbomedics Inc. | Heart valve leaflet |
US7147663B1 (en) | 1999-04-23 | 2006-12-12 | St. Jude Medical Atg, Inc. | Artificial heart valve attachment apparatus and methods |
EP1171059B1 (en) | 1999-04-23 | 2005-11-02 | St. Jude Medical ATG, Inc. | Artificial heart valve attachment apparatus |
BR0010096A (en) | 1999-04-28 | 2002-02-19 | St Jude Medical | Cardiac valve prosthesis, kit, process to connect a cardiac valve prosthesis to a patient, and a fastener applicator to implant a cardiac valve prosthesis |
AU4673700A (en) | 1999-05-06 | 2000-11-21 | Venpro Corporation | Implant for restoring venous valvular function |
US6309417B1 (en) | 1999-05-12 | 2001-10-30 | Paul A. Spence | Heart valve and apparatus for replacement thereof |
US6790229B1 (en) | 1999-05-25 | 2004-09-14 | Eric Berreklouw | Fixing device, in particular for fixing to vascular wall tissue |
US7628803B2 (en) | 2001-02-05 | 2009-12-08 | Cook Incorporated | Implantable vascular device |
US6241763B1 (en) | 1999-06-08 | 2001-06-05 | William J. Drasler | In situ venous valve device and method of formation |
SE514718C2 (en) | 1999-06-29 | 2001-04-09 | Jan Otto Solem | Apparatus for treating defective closure of the mitral valve apparatus |
US6997951B2 (en) | 1999-06-30 | 2006-02-14 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US7192442B2 (en) | 1999-06-30 | 2007-03-20 | Edwards Lifesciences Ag | Method and device for treatment of mitral insufficiency |
US6312465B1 (en) | 1999-07-23 | 2001-11-06 | Sulzer Carbomedics Inc. | Heart valve prosthesis with a resiliently deformable retaining member |
GB2369781B (en) | 1999-08-27 | 2003-11-12 | Kimberly Clark Co | Absorbent article having pleated extensible absorbent layer |
US6315793B1 (en) | 1999-09-08 | 2001-11-13 | Medical Carbon Research Institute, Llc | Prosthetic venous valves |
DE19945587A1 (en) | 1999-09-23 | 2001-05-10 | Co Don Ag | Procedure for inserting implants into human organs |
US6371983B1 (en) * | 1999-10-04 | 2002-04-16 | Ernest Lane | Bioprosthetic heart valve |
US6312447B1 (en) * | 1999-10-13 | 2001-11-06 | The General Hospital Corporation | Devices and methods for percutaneous mitral valve repair |
US6626930B1 (en) | 1999-10-21 | 2003-09-30 | Edwards Lifesciences Corporation | Minimally invasive mitral valve repair method and apparatus |
US6440164B1 (en) * | 1999-10-21 | 2002-08-27 | Scimed Life Systems, Inc. | Implantable prosthetic valve |
JP2001120582A (en) | 1999-10-22 | 2001-05-08 | Gunze Ltd | Artificial cardiac valve and method of manufacturing the same |
US6926730B1 (en) | 2000-10-10 | 2005-08-09 | Medtronic, Inc. | Minimally invasive valve repair procedure and apparatus |
AU1068800A (en) | 1999-11-10 | 2001-06-06 | Impsa International Incorporated | Prosthetic heart valve |
FR2800984B1 (en) | 1999-11-17 | 2001-12-14 | Jacques Seguin | DEVICE FOR REPLACING A HEART VALVE PERCUTANEOUSLY |
US8579966B2 (en) | 1999-11-17 | 2013-11-12 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US7018406B2 (en) | 1999-11-17 | 2006-03-28 | Corevalve Sa | Prosthetic valve for transluminal delivery |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
US7195641B2 (en) * | 1999-11-19 | 2007-03-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Valvular prostheses having metal or pseudometallic construction and methods of manufacture |
US6709457B1 (en) | 1999-11-24 | 2004-03-23 | St. Jude Medical, Inc. | Attachment of suture cuff to prosthetic heart valve |
SE514886C2 (en) | 1999-12-14 | 2001-05-14 | Jcl Technic Ab | Vascular valve, such as heart valve, and process for its manufacture |
US7052507B2 (en) | 1999-12-24 | 2006-05-30 | Toray Industries, Inc. | Catheter with balloon |
US6663667B2 (en) | 1999-12-29 | 2003-12-16 | Edwards Lifesciences Corporation | Towel graft means for enhancing tissue ingrowth in vascular grafts |
AU2001229476A1 (en) | 2000-01-14 | 2001-07-24 | Viacor Incorporated | Tissue annuloplasty band and apparatus and method for fashioning, sizing and implanting the same |
JP2005503178A (en) * | 2000-01-25 | 2005-02-03 | ボストン サイエンティフィック リミテッド | Manufacturing medical devices by vapor deposition |
JP2003520645A (en) | 2000-01-25 | 2003-07-08 | エドワーズ ライフサイエンシーズ コーポレイション | Bioactive coating prevents tissue overgrowth on artificial heart valves |
US7749245B2 (en) * | 2000-01-27 | 2010-07-06 | Medtronic, Inc. | Cardiac valve procedure methods and devices |
MXPA02007253A (en) | 2000-01-27 | 2003-09-22 | 3F Therapeutics Inc | Prosthetic heart valve. |
US6872226B2 (en) | 2001-01-29 | 2005-03-29 | 3F Therapeutics, Inc. | Method of cutting material for use in implantable medical device |
US7011682B2 (en) | 2000-01-31 | 2006-03-14 | Edwards Lifesciences Ag | Methods and apparatus for remodeling an extravascular tissue structure |
US6989028B2 (en) * | 2000-01-31 | 2006-01-24 | Edwards Lifesciences Ag | Medical system and method for remodeling an extravascular tissue structure |
DE60128069D1 (en) | 2000-01-31 | 2007-06-06 | Cook Biotech Inc | STENT VALVE FLAP |
US6402781B1 (en) | 2000-01-31 | 2002-06-11 | Mitralife | Percutaneous mitral annuloplasty and cardiac reinforcement |
US20050070999A1 (en) | 2000-02-02 | 2005-03-31 | Spence Paul A. | Heart valve repair apparatus and methods |
US6797002B2 (en) | 2000-02-02 | 2004-09-28 | Paul A. Spence | Heart valve repair apparatus and methods |
US6821297B2 (en) | 2000-02-02 | 2004-11-23 | Robert V. Snyders | Artificial heart valve, implantation instrument and method therefor |
AU2001233227A1 (en) | 2000-02-02 | 2001-08-14 | Robert V. Snyders | Artificial heart valve |
US20050267560A1 (en) | 2000-02-03 | 2005-12-01 | Cook Incorporated | Implantable bioabsorbable valve support frame |
ES2236204T3 (en) * | 2000-03-03 | 2005-07-16 | Cook Incorporated | BULBIFORM AND STENT VALVE FOR THE TREATMENT OF VASCULAR REFLUX. |
PT1259192E (en) | 2000-03-03 | 2004-04-30 | Cook Inc | ENDOVASCULAR DEVICE WITH A ENDOPROTESE |
US20030229393A1 (en) | 2001-03-15 | 2003-12-11 | Kutryk Michael J. B. | Medical device with coating that promotes cell adherence and differentiation |
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
US6652583B2 (en) | 2000-04-07 | 2003-11-25 | Rhode Island Hospital | Cardiac valve replacement |
US6729356B1 (en) | 2000-04-27 | 2004-05-04 | Endovascular Technologies, Inc. | Endovascular graft for providing a seal with vasculature |
AU6738801A (en) * | 2000-04-27 | 2001-11-07 | Axel Haverich | Individual venous valve prosthesis |
US7083628B2 (en) | 2002-09-03 | 2006-08-01 | Edwards Lifesciences Corporation | Single catheter mitral valve repair device and method for use |
US6869444B2 (en) | 2000-05-22 | 2005-03-22 | Shlomo Gabbay | Low invasive implantable cardiac prosthesis and method for helping improve operation of a heart valve |
US8366769B2 (en) | 2000-06-01 | 2013-02-05 | Edwards Lifesciences Corporation | Low-profile, pivotable heart valve sewing ring |
US6805711B2 (en) | 2000-06-02 | 2004-10-19 | 3F Therapeutics, Inc. | Expandable medical implant and percutaneous delivery |
US20050043757A1 (en) | 2000-06-12 | 2005-02-24 | Michael Arad | Medical devices formed from shape memory alloys displaying a stress-retained martensitic state and method for use thereof |
WO2001097897A1 (en) | 2000-06-20 | 2001-12-27 | Starion Instruments, Inc. | Devices and methods for repair of valves in the human body |
US6840246B2 (en) * | 2000-06-20 | 2005-01-11 | University Of Maryland, Baltimore | Apparatuses and methods for performing minimally invasive diagnostic and surgical procedures inside of a beating heart |
ATE381291T1 (en) | 2000-06-23 | 2008-01-15 | Viacor Inc | AUTOMATIC ANNUAL FOLDING FOR MITRAL VALVE REPAIR |
US6676698B2 (en) | 2000-06-26 | 2004-01-13 | Rex Medicol, L.P. | Vascular device with valve for approximating vessel wall |
US6695878B2 (en) | 2000-06-26 | 2004-02-24 | Rex Medical, L.P. | Vascular device for valve leaflet apposition |
SE0002514D0 (en) | 2000-06-30 | 2000-06-30 | Pacesetter Ab | Medical device |
AU2001271667A1 (en) | 2000-06-30 | 2002-01-14 | Viacor Incorporated | Method and apparatus for performing a procedure on a cardiac valve |
US6419696B1 (en) | 2000-07-06 | 2002-07-16 | Paul A. Spence | Annuloplasty devices and related heart valve repair methods |
US7077861B2 (en) | 2000-07-06 | 2006-07-18 | Medtentia Ab | Annuloplasty instrument |
US6695817B1 (en) * | 2000-07-11 | 2004-02-24 | Icu Medical, Inc. | Medical valve with positive flow characteristics |
SE0002878D0 (en) | 2000-08-11 | 2000-08-11 | Kimblad Ola | Device and method of treatment of atrioventricular regurgitation |
US6635085B1 (en) | 2000-08-17 | 2003-10-21 | Carbomedics Inc. | Heart valve stent with alignment posts |
US6572652B2 (en) | 2000-08-29 | 2003-06-03 | Venpro Corporation | Method and devices for decreasing elevated pulmonary venous pressure |
WO2002019951A1 (en) * | 2000-09-07 | 2002-03-14 | Viacor, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US20060142848A1 (en) | 2000-09-12 | 2006-06-29 | Shlomo Gabbay | Extra-anatomic aortic valve placement |
WO2002022054A1 (en) | 2000-09-12 | 2002-03-21 | Gabbay S | Valvular prosthesis and method of using same |
DE10046550A1 (en) | 2000-09-19 | 2002-03-28 | Adiam Life Science Ag | Prosthetic mitral heart valve consists of support housing with base ring and two stanchions |
US6893459B1 (en) | 2000-09-20 | 2005-05-17 | Ample Medical, Inc. | Heart valve annulus device and method of using same |
US20060106278A1 (en) | 2004-05-14 | 2006-05-18 | Ample Medical, Inc. | Devices, systems, and methods for reshaping a heart valve annulus, including the use of an adjustable bridge implant system |
US8956407B2 (en) | 2000-09-20 | 2015-02-17 | Mvrx, Inc. | Methods for reshaping a heart valve annulus using a tensioning implant |
US20050228422A1 (en) | 2002-11-26 | 2005-10-13 | Ample Medical, Inc. | Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools |
US8784482B2 (en) | 2000-09-20 | 2014-07-22 | Mvrx, Inc. | Method of reshaping a heart valve annulus using an intravascular device |
US20060106279A1 (en) | 2004-05-14 | 2006-05-18 | Ample Medical, Inc. | Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop |
US6461382B1 (en) | 2000-09-22 | 2002-10-08 | Edwards Lifesciences Corporation | Flexible heart valve having moveable commissures |
AU2001296442A1 (en) | 2000-09-29 | 2002-04-08 | Tricardia, L.L.C. | Venous valvuloplasty device |
US6602288B1 (en) | 2000-10-05 | 2003-08-05 | Edwards Lifesciences Corporation | Minimally-invasive annuloplasty repair segment delivery template, system and method of use |
US6723038B1 (en) | 2000-10-06 | 2004-04-20 | Myocor, Inc. | Methods and devices for improving mitral valve function |
DE10050092A1 (en) * | 2000-10-09 | 2002-04-11 | Adiam Life Science Ag | Prosthetic mitral valve comprises base and valve flaps which have core which is more rigid than their surface layer |
DE10049865B8 (en) | 2000-10-09 | 2008-10-30 | Universitätsklinikum Freiburg | Device for removing an aortic valve on the human heart by means of a minimally invasive surgical procedure |
US6918917B1 (en) | 2000-10-10 | 2005-07-19 | Medtronic, Inc. | Minimally invasive annuloplasty procedure and apparatus |
US6913608B2 (en) | 2000-10-23 | 2005-07-05 | Viacor, Inc. | Automated annular plication for mitral valve repair |
US7070618B2 (en) | 2000-10-25 | 2006-07-04 | Viacor, Inc. | Mitral shield |
US6602286B1 (en) | 2000-10-26 | 2003-08-05 | Ernst Peter Strecker | Implantable valve system |
US6814754B2 (en) | 2000-10-30 | 2004-11-09 | Secant Medical, Llc | Woven tubular graft with regions of varying flexibility |
US7267685B2 (en) | 2000-11-16 | 2007-09-11 | Cordis Corporation | Bilateral extension prosthesis and method of delivery |
US6974476B2 (en) * | 2003-05-05 | 2005-12-13 | Rex Medical, L.P. | Percutaneous aortic valve |
US6730122B1 (en) | 2000-11-28 | 2004-05-04 | St. Jude Medical, Inc. | Prosthetic heart valve with increased lumen |
US6953332B1 (en) | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
AU2002236640A1 (en) | 2000-12-15 | 2002-06-24 | Viacor, Inc. | Apparatus and method for replacing aortic valve |
US6716244B2 (en) | 2000-12-20 | 2004-04-06 | Carbomedics, Inc. | Sewing cuff assembly for heart valves |
US6966925B2 (en) | 2000-12-21 | 2005-11-22 | Edwards Lifesciences Corporation | Heart valve holder and method for resisting suture looping |
US6964682B2 (en) | 2000-12-21 | 2005-11-15 | Edwards Lifesciences Corporation | Heart valve holder that resist suture looping |
US6669725B2 (en) | 2000-12-28 | 2003-12-30 | Centerpulse Biologics Inc. | Annuloplasty ring for regeneration of diseased or damaged heart valve annulus |
AU2002255486A1 (en) | 2001-01-19 | 2002-09-19 | Walid Najib Aboul-Hosn | Apparatus and method for maintaining flow through a vessel or duct |
US7510576B2 (en) | 2001-01-30 | 2009-03-31 | Edwards Lifesciences Ag | Transluminal mitral annuloplasty |
US6810882B2 (en) | 2001-01-30 | 2004-11-02 | Ev3 Santa Rosa, Inc. | Transluminal mitral annuloplasty |
US20050182483A1 (en) | 2004-02-11 | 2005-08-18 | Cook Incorporated | Percutaneously placed prosthesis with thromboresistant valve portion |
JP4184794B2 (en) | 2001-02-05 | 2008-11-19 | ビアカー・インコーポレーテッド | Method and apparatus for improving mitral valve function |
US6790231B2 (en) | 2001-02-05 | 2004-09-14 | Viacor, Inc. | Apparatus and method for reducing mitral regurgitation |
US20020107531A1 (en) | 2001-02-06 | 2002-08-08 | Schreck Stefan G. | Method and system for tissue repair using dual catheters |
US6863688B2 (en) | 2001-02-15 | 2005-03-08 | Spinecore, Inc. | Intervertebral spacer device utilizing a spirally slotted belleville washer having radially spaced concentric grooves |
US6786924B2 (en) | 2001-03-15 | 2004-09-07 | Medtronic, Inc. | Annuloplasty band and method |
US6955689B2 (en) | 2001-03-15 | 2005-10-18 | Medtronic, Inc. | Annuloplasty band and method |
US6916338B2 (en) | 2001-03-16 | 2005-07-12 | Mayo Foundation For Medical Education And Research | Synthetic leaflets for heart valve repair or replacement |
US6503272B2 (en) | 2001-03-21 | 2003-01-07 | Cordis Corporation | Stent-based venous valves |
AUPR389201A0 (en) | 2001-03-23 | 2001-04-12 | Lane, Rodney James | Improvements in design of external vendus valve stents for the correction fo incompetent vendods valves |
WO2002076284A2 (en) | 2001-03-23 | 2002-10-03 | Viacor, Inc. | Method and apparatus for reducing mitral regurgitation |
US6773456B1 (en) | 2001-03-23 | 2004-08-10 | Endovascular Technologies, Inc. | Adjustable customized endovascular graft |
US7556646B2 (en) * | 2001-09-13 | 2009-07-07 | Edwards Lifesciences Corporation | Methods and apparatuses for deploying minimally-invasive heart valves |
DK1245202T3 (en) | 2001-03-27 | 2004-08-30 | Cook William Europ | Aortic device |
JP2002293678A (en) | 2001-03-28 | 2002-10-09 | Fuji Photo Film Co Ltd | Method for forming image |
US7186264B2 (en) | 2001-03-29 | 2007-03-06 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
US6958076B2 (en) | 2001-04-16 | 2005-10-25 | Biomedical Research Associates Inc. | Implantable venous valve |
US20060069429A1 (en) | 2001-04-24 | 2006-03-30 | Spence Paul A | Tissue fastening systems and methods utilizing magnetic guidance |
US7037334B1 (en) | 2001-04-24 | 2006-05-02 | Mitralign, Inc. | Method and apparatus for catheter-based annuloplasty using local plications |
US6619291B2 (en) * | 2001-04-24 | 2003-09-16 | Edwin J. Hlavka | Method and apparatus for catheter-based annuloplasty |
US20050125011A1 (en) | 2001-04-24 | 2005-06-09 | Spence Paul A. | Tissue fastening systems and methods utilizing magnetic guidance |
DE10121210B4 (en) | 2001-04-30 | 2005-11-17 | Universitätsklinikum Freiburg | Anchoring element for the intraluminal anchoring of a heart valve replacement and method for its production |
US20040193253A1 (en) | 2001-04-30 | 2004-09-30 | Thorpe Patricia E | Replacement venous valve |
US6682558B2 (en) | 2001-05-10 | 2004-01-27 | 3F Therapeutics, Inc. | Delivery system for a stentless valve bioprosthesis |
US6676702B2 (en) | 2001-05-14 | 2004-01-13 | Cardiac Dimensions, Inc. | Mitral valve therapy assembly and method |
US6800090B2 (en) * | 2001-05-14 | 2004-10-05 | Cardiac Dimensions, Inc. | Mitral valve therapy device, system and method |
ITMI20011012A1 (en) | 2001-05-17 | 2002-11-17 | Ottavio Alfieri | ANNULAR PROSTHESIS FOR MITRAL VALVE |
US6936067B2 (en) | 2001-05-17 | 2005-08-30 | St. Jude Medical Inc. | Prosthetic heart valve with slit stent |
US6858039B2 (en) * | 2002-07-08 | 2005-02-22 | Edwards Lifesciences Corporation | Mitral valve annuloplasty ring having a posterior bow |
US20020173811A1 (en) | 2001-05-21 | 2002-11-21 | Hosheng Tu | Apparatus and methods for valve removal |
US7510571B2 (en) | 2001-06-11 | 2009-03-31 | Boston Scientific, Scimed, Inc. | Pleated composite ePTFE/textile hybrid covering |
US7544206B2 (en) | 2001-06-29 | 2009-06-09 | Medtronic, Inc. | Method and apparatus for resecting and replacing an aortic valve |
FR2826863B1 (en) | 2001-07-04 | 2003-09-26 | Jacques Seguin | ASSEMBLY FOR PLACING A PROSTHETIC VALVE IN A BODY CONDUIT |
US7377938B2 (en) | 2001-07-19 | 2008-05-27 | The Cleveland Clinic Foundation | Prosthetic cardiac value and method for making same |
TW475038B (en) | 2001-07-24 | 2002-02-01 | Silitek Corp | Bearing sleeve structure and its manufacture |
FR2828091B1 (en) * | 2001-07-31 | 2003-11-21 | Seguin Jacques | ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT |
US6726716B2 (en) | 2001-08-24 | 2004-04-27 | Edwards Lifesciences Corporation | Self-molding annuloplasty ring |
US6749630B2 (en) | 2001-08-28 | 2004-06-15 | Edwards Lifesciences Corporation | Tricuspid ring and template |
US6723122B2 (en) | 2001-08-30 | 2004-04-20 | Edwards Lifesciences Corporation | Container and method for storing and delivering minimally-invasive heart valves |
US6842226B2 (en) * | 2001-09-21 | 2005-01-11 | Nikon Corporation | Flexure supported wafer table |
US20030065386A1 (en) | 2001-09-28 | 2003-04-03 | Weadock Kevin Shaun | Radially expandable endoprosthesis device with two-stage deployment |
CA2455444A1 (en) | 2001-10-01 | 2003-04-10 | Ample Medical, Inc. | Methods and devices for heart valve treatments |
DE10297328T5 (en) | 2001-10-09 | 2005-01-05 | Endoscopic Technologies, Inc., Danville | A method and apparatus for improved rigidity in the connection arrangement of a flexible arm |
US6893460B2 (en) * | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
US7192441B2 (en) | 2001-10-16 | 2007-03-20 | Scimed Life Systems, Inc. | Aortic artery aneurysm endovascular prosthesis |
US7144363B2 (en) | 2001-10-16 | 2006-12-05 | Extensia Medical, Inc. | Systems for heart treatment |
US6726715B2 (en) | 2001-10-23 | 2004-04-27 | Childrens Medical Center Corporation | Fiber-reinforced heart valve prosthesis |
US20060020336A1 (en) * | 2001-10-23 | 2006-01-26 | Liddicoat John R | Automated annular plication for mitral valve repair |
AUPR847201A0 (en) | 2001-10-26 | 2001-11-15 | Cook Incorporated | Endoluminal graft |
US7052487B2 (en) * | 2001-10-26 | 2006-05-30 | Cohn William E | Method and apparatus for reducing mitral regurgitation |
GB0125925D0 (en) | 2001-10-29 | 2001-12-19 | Univ Glasgow | Mitral valve prosthesis |
US20040044403A1 (en) * | 2001-10-30 | 2004-03-04 | Joyce Bischoff | Tissue-engineered vascular structures |
US6824562B2 (en) | 2002-05-08 | 2004-11-30 | Cardiac Dimensions, Inc. | Body lumen device anchor, device and assembly |
US7311729B2 (en) | 2002-01-30 | 2007-12-25 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US6949122B2 (en) | 2001-11-01 | 2005-09-27 | Cardiac Dimensions, Inc. | Focused compression mitral valve device and method |
US6805710B2 (en) | 2001-11-13 | 2004-10-19 | Edwards Lifesciences Corporation | Mitral valve annuloplasty ring for molding left ventricle geometry |
US6575971B2 (en) | 2001-11-15 | 2003-06-10 | Quantum Cor, Inc. | Cardiac valve leaflet stapler device and methods thereof |
US6719784B2 (en) | 2001-11-21 | 2004-04-13 | Scimed Life Systems, Inc. | Counter rotational layering of ePTFE to improve mechanical properties of a prosthesis |
US20050228479A1 (en) | 2001-11-29 | 2005-10-13 | Cook Incorporated | Medical device delivery system |
US6976995B2 (en) | 2002-01-30 | 2005-12-20 | Cardiac Dimensions, Inc. | Fixed length anchor and pull mitral valve device and method |
US6793673B2 (en) | 2002-12-26 | 2004-09-21 | Cardiac Dimensions, Inc. | System and method to effect mitral valve annulus of a heart |
US7179282B2 (en) * | 2001-12-05 | 2007-02-20 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US6908478B2 (en) | 2001-12-05 | 2005-06-21 | Cardiac Dimensions, Inc. | Anchor and pull mitral valve device and method |
US6978176B2 (en) | 2001-12-08 | 2005-12-20 | Lattouf Omar M | Treatment for patient with congestive heart failure |
US6755857B2 (en) | 2001-12-12 | 2004-06-29 | Sulzer Carbomedics Inc. | Polymer heart valve with perforated stent and sewing cuff |
JP4230915B2 (en) | 2001-12-21 | 2009-02-25 | シムチャ ミロ | Annuloplasty ring transplantation system |
US6951573B1 (en) | 2001-12-22 | 2005-10-04 | Dilling Emery W | Prosthetic aortic valve |
US20030120340A1 (en) | 2001-12-26 | 2003-06-26 | Jan Liska | Mitral and tricuspid valve repair |
US7201771B2 (en) | 2001-12-27 | 2007-04-10 | Arbor Surgical Technologies, Inc. | Bioprosthetic heart valve |
US6881224B2 (en) | 2001-12-28 | 2005-04-19 | St. Jude Medical, Inc. | Fatigue test for prosthetic stent |
EP1458313B1 (en) | 2001-12-28 | 2010-03-31 | Edwards Lifesciences AG | Delayed memory device |
US7033390B2 (en) * | 2002-01-02 | 2006-04-25 | Medtronic, Inc. | Prosthetic heart valve system |
US20030130729A1 (en) | 2002-01-04 | 2003-07-10 | David Paniagua | Percutaneously implantable replacement heart valve device and method of making same |
US8308797B2 (en) | 2002-01-04 | 2012-11-13 | Colibri Heart Valve, LLC | Percutaneously implantable replacement heart valve device and method of making same |
US6764510B2 (en) | 2002-01-09 | 2004-07-20 | Myocor, Inc. | Devices and methods for heart valve treatment |
US6911040B2 (en) | 2002-01-24 | 2005-06-28 | Cordis Corporation | Covered segmented stent |
US7125420B2 (en) | 2002-02-05 | 2006-10-24 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
WO2003070124A2 (en) | 2002-02-20 | 2003-08-28 | Osse Francisco J | Venous bi-valve |
DE10208202A1 (en) | 2002-02-26 | 2003-09-11 | Karlsruhe Forschzent | vein graft |
US6974464B2 (en) | 2002-02-28 | 2005-12-13 | 3F Therapeutics, Inc. | Supportless atrioventricular heart valve and minimally invasive delivery systems thereof |
US7048754B2 (en) | 2002-03-01 | 2006-05-23 | Evalve, Inc. | Suture fasteners and methods of use |
US6716241B2 (en) | 2002-03-05 | 2004-04-06 | John G. Wilder | Venous valve and graft combination |
US7004958B2 (en) * | 2002-03-06 | 2006-02-28 | Cardiac Dimensions, Inc. | Transvenous staples, assembly and method for mitral valve repair |
US6797001B2 (en) | 2002-03-11 | 2004-09-28 | Cardiac Dimensions, Inc. | Device, assembly and method for mitral valve repair |
US6719786B2 (en) | 2002-03-18 | 2004-04-13 | Medtronic, Inc. | Flexible annuloplasty prosthesis and holder |
US7163556B2 (en) * | 2002-03-21 | 2007-01-16 | Providence Health System - Oregon | Bioprosthesis and method for suturelessly making same |
US7094244B2 (en) * | 2002-03-26 | 2006-08-22 | Edwards Lifesciences Corporation | Sequential heart valve leaflet repair device and method of use |
US6752828B2 (en) | 2002-04-03 | 2004-06-22 | Scimed Life Systems, Inc. | Artificial valve |
US7125418B2 (en) | 2002-04-16 | 2006-10-24 | The International Heart Institute Of Montana Foundation | Sigmoid valve and method for its percutaneous implantation |
WO2003088809A2 (en) * | 2002-04-16 | 2003-10-30 | Viacor, Inc. | Method and apparatus for resecting and replacing an aortic valve |
AU2003230938A1 (en) | 2002-04-16 | 2003-11-03 | Viacor, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US7160320B2 (en) | 2002-04-16 | 2007-01-09 | The International Heart Institute Of Montana Foundation | Reed valve for implantation into mammalian blood vessels and heart with optional temporary or permanent support |
DE10217559B4 (en) | 2002-04-19 | 2004-02-19 | Universitätsklinikum Freiburg | Device for minimally invasive, intravascular aortic valve extraction |
FR2838631B1 (en) | 2002-04-23 | 2004-12-24 | Engeneering And Technological | METHOD FOR PRODUCING AN AORTIC OR MITRAL HEART VALVE PROSTHESIS AND AORTIC OR MITRAL HEART VALVE PROSTHESIS THUS OBTAINED |
US6761735B2 (en) | 2002-04-25 | 2004-07-13 | Medtronic, Inc. | Heart valve fixation process and apparatus |
US20030204249A1 (en) | 2002-04-25 | 2003-10-30 | Michel Letort | Endovascular stent graft and fixation cuff |
US6676699B2 (en) * | 2002-04-26 | 2004-01-13 | Medtronic Ave, Inc | Stent graft with integrated valve device and method |
AU2003234505A1 (en) | 2002-05-03 | 2003-11-17 | The General Hospital Corporation | Involuted endovascular valve and method of construction |
DE60325356D1 (en) | 2002-05-08 | 2009-01-29 | Cardiac Dimensions Inc | DEVICE FOR CHANGING THE FORM OF A MITRAL FLAP |
US7351256B2 (en) | 2002-05-10 | 2008-04-01 | Cordis Corporation | Frame based unidirectional flow prosthetic implant |
AU2003225291A1 (en) | 2002-05-10 | 2003-11-11 | Cordis Corporation | Method of making a medical device having a thin wall tubular membrane over a structural frame |
DE10221076A1 (en) | 2002-05-11 | 2003-11-27 | Ruesch Willy Gmbh | stent |
WO2003096932A1 (en) | 2002-05-17 | 2003-11-27 | Bionethos Holding Gmbh | Medical device for the treatment of a body vessel or another tubular structure in the body |
US20030229394A1 (en) | 2002-06-06 | 2003-12-11 | Ogle Matthew F. | Processed tissue for medical device formation |
US7264632B2 (en) | 2002-06-07 | 2007-09-04 | Medtronic Vascular, Inc. | Controlled deployment delivery system |
AU2003247526A1 (en) | 2002-06-12 | 2003-12-31 | Mitral Interventions, Inc. | Method and apparatus for tissue connection |
US20050107811A1 (en) | 2002-06-13 | 2005-05-19 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US7666193B2 (en) | 2002-06-13 | 2010-02-23 | Guided Delivery Sytems, Inc. | Delivery devices and methods for heart valve repair |
US7758637B2 (en) | 2003-02-06 | 2010-07-20 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US8287555B2 (en) | 2003-02-06 | 2012-10-16 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US20050216078A1 (en) | 2002-06-13 | 2005-09-29 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US6986775B2 (en) | 2002-06-13 | 2006-01-17 | Guided Delivery Systems, Inc. | Devices and methods for heart valve repair |
US20040243227A1 (en) | 2002-06-13 | 2004-12-02 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US7753922B2 (en) | 2003-09-04 | 2010-07-13 | Guided Delivery Systems, Inc. | Devices and methods for cardiac annulus stabilization and treatment |
US7753858B2 (en) * | 2002-06-13 | 2010-07-13 | Guided Delivery Systems, Inc. | Delivery devices and methods for heart valve repair |
US7044962B2 (en) | 2002-06-25 | 2006-05-16 | Scimed Life Systems, Inc. | Implantable prosthesis with displaceable skirt |
US7959674B2 (en) | 2002-07-16 | 2011-06-14 | Medtronic, Inc. | Suture locking assembly and method of use |
US7172625B2 (en) * | 2002-07-16 | 2007-02-06 | Medtronic, Inc. | Suturing rings for implantable heart valve prostheses |
US7578843B2 (en) * | 2002-07-16 | 2009-08-25 | Medtronic, Inc. | Heart valve prosthesis |
US6761734B2 (en) | 2002-07-22 | 2004-07-13 | William S. Suhr | Segmented balloon catheter for stenting bifurcation lesions |
US8172856B2 (en) | 2002-08-02 | 2012-05-08 | Cedars-Sinai Medical Center | Methods and apparatus for atrioventricular valve repair |
US20040024452A1 (en) * | 2002-08-02 | 2004-02-05 | Kruse Steven D. | Valved prostheses with preformed tissue leaflets |
EP1388328A1 (en) | 2002-08-07 | 2004-02-11 | Abbott Laboratories Vascular Enterprises Limited | Apparatus for delivering and deployment of an expandable stent within a blood vessel |
DE10362367B3 (en) | 2002-08-13 | 2022-02-24 | Jenavalve Technology Inc. | Device for anchoring and aligning prosthetic heart valves |
JP4929428B2 (en) | 2002-08-13 | 2012-05-09 | ロバート・エー・レヴィン | Cardiac device and method for percutaneous repair of atrioventricular valve |
US7041132B2 (en) * | 2002-08-16 | 2006-05-09 | 3F Therapeutics, Inc, | Percutaneously delivered heart valve and delivery means thereof |
US7175652B2 (en) | 2002-08-20 | 2007-02-13 | Cook Incorporated | Stent graft with improved proximal end |
US6889103B2 (en) | 2002-08-22 | 2005-05-03 | Atser | Systems and methods for realtime determination of asphalt content |
EP1592367B1 (en) | 2002-08-28 | 2016-04-13 | HLT, Inc. | Method and device for treating diseased valve |
US6875231B2 (en) | 2002-09-11 | 2005-04-05 | 3F Therapeutics, Inc. | Percutaneously deliverable heart valve |
AU2003263454A1 (en) * | 2002-09-19 | 2004-04-08 | Petrus Besselink | Vascular filter with improved strength and flexibility |
CO5500017A1 (en) | 2002-09-23 | 2005-03-31 | 3F Therapeutics Inc | MITRAL PROTESTIC VALVE |
US20040059409A1 (en) | 2002-09-24 | 2004-03-25 | Stenzel Eric B. | Method of applying coatings to a medical device |
US20040059412A1 (en) | 2002-09-25 | 2004-03-25 | Lytle Thomas William | Heart valve holder |
US20040060161A1 (en) | 2002-09-27 | 2004-04-01 | David Leal | Methods of forming a heart valve stent |
AU2003277118A1 (en) | 2002-10-01 | 2004-04-23 | Ample Medical, Inc. | Devices for retaining native heart valve leaflet |
JP2006501033A (en) | 2002-10-01 | 2006-01-12 | アンプル メディカル, インコーポレイテッド | Device, system and method for reshaping a heart valve annulus |
AU2003277115A1 (en) | 2002-10-01 | 2004-04-23 | Ample Medical, Inc. | Device and method for repairing a native heart valve leaflet |
EP1560545B1 (en) | 2002-10-10 | 2008-07-30 | The Cleveland Clinic Foundation | Apparatus for replacing a mitral valve with a stentless bioprosthetic valve having chordae |
US7087064B1 (en) * | 2002-10-15 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Apparatuses and methods for heart valve repair |
JP2006503651A (en) | 2002-10-21 | 2006-02-02 | ミトラリグン・インコーポレーテッド | Method and apparatus for performing catheter-based annuloplasty surgery using plication |
US6824041B2 (en) | 2002-10-21 | 2004-11-30 | Agilent Technologies, Inc. | High temperature eutectic solder ball attach |
US20050119735A1 (en) | 2002-10-21 | 2005-06-02 | Spence Paul A. | Tissue fastening systems and methods utilizing magnetic guidance |
AU2003285943B2 (en) | 2002-10-24 | 2008-08-21 | Boston Scientific Limited | Venous valve apparatus and method |
US20040082910A1 (en) | 2002-10-29 | 2004-04-29 | Constantz Brent R. | Devices and methods for treating aortic valve stenosis |
GB0225075D0 (en) | 2002-10-29 | 2002-12-04 | Smiths Group Plc | Valves |
US7112219B2 (en) | 2002-11-12 | 2006-09-26 | Myocor, Inc. | Devices and methods for heart valve treatment |
US7247134B2 (en) | 2002-11-12 | 2007-07-24 | Myocor, Inc. | Devices and methods for heart valve treatment |
ATE516756T1 (en) | 2002-11-12 | 2011-08-15 | Edwards Lifesciences Ag | DEVICES FOR TREATING THE HEART VALVE |
EP2345380B1 (en) | 2002-11-13 | 2018-01-10 | Medtronic, Inc. | Cardiac valve procedure devices |
WO2004043273A2 (en) | 2002-11-13 | 2004-05-27 | Rosengart Todd K | Apparatus and method for cutting a heart valve |
US20040097979A1 (en) | 2002-11-14 | 2004-05-20 | Oleg Svanidze | Aortic valve implantation device |
AU2003290979A1 (en) | 2002-11-15 | 2004-06-15 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method and device for catheter-based repair of cardiac valves |
US6945978B1 (en) | 2002-11-15 | 2005-09-20 | Advanced Cardiovascular Systems, Inc. | Heart valve catheter |
FR2847151B1 (en) | 2002-11-15 | 2005-01-21 | Claude Mialhe | OCCLUSIVE DEVICE WITH MEDICAL OR SURGICAL DESTINATION |
US7485143B2 (en) | 2002-11-15 | 2009-02-03 | Abbott Cardiovascular Systems Inc. | Apparatuses and methods for heart valve repair |
FR2847155B1 (en) | 2002-11-20 | 2005-08-05 | Younes Boudjemline | METHOD FOR MANUFACTURING A MEDICAL IMPLANT WITH ADJUSTED STRUCTURE AND IMPLANT OBTAINED THEREBY |
US20040122515A1 (en) | 2002-11-21 | 2004-06-24 | Xi Chu | Prosthetic valves and methods of manufacturing |
US7316708B2 (en) | 2002-12-05 | 2008-01-08 | Cardiac Dimensions, Inc. | Medical device delivery system |
US8551162B2 (en) | 2002-12-20 | 2013-10-08 | Medtronic, Inc. | Biologically implantable prosthesis |
US6945957B2 (en) | 2002-12-30 | 2005-09-20 | Scimed Life Systems, Inc. | Valve treatment catheter and methods |
US20040133240A1 (en) | 2003-01-07 | 2004-07-08 | Cardiac Dimensions, Inc. | Electrotherapy system, device, and method for treatment of cardiac valve dysfunction |
US6830585B1 (en) | 2003-01-14 | 2004-12-14 | 3F Therapeutics, Inc. | Percutaneously deliverable heart valve and methods of implantation |
US6997950B2 (en) * | 2003-01-16 | 2006-02-14 | Chawla Surendra K | Valve repair device |
US6889148B2 (en) | 2003-01-21 | 2005-05-03 | Atser | Process control system to manage materials used in construction |
US6746463B1 (en) | 2003-01-27 | 2004-06-08 | Scimed Life Systems, Inc | Device for percutaneous cutting and dilating a stenosis of the aortic valve |
US7762044B2 (en) | 2003-01-27 | 2010-07-27 | Medtronic Vascular, Inc. | Packaging for stent delivery systems |
US7220271B2 (en) | 2003-01-30 | 2007-05-22 | Ev3 Inc. | Embolic filters having multiple layers and controlled pore size |
US7972371B2 (en) | 2003-01-31 | 2011-07-05 | Koninklijke Philips Electronics N.V. | Magnetic resonance compatible stent |
US7314485B2 (en) | 2003-02-03 | 2008-01-01 | Cardiac Dimensions, Inc. | Mitral valve device using conditioned shape memory alloy |
US20040158321A1 (en) | 2003-02-12 | 2004-08-12 | Cardiac Dimensions, Inc. | Method of implanting a mitral valve therapy device |
US20040254600A1 (en) | 2003-02-26 | 2004-12-16 | David Zarbatany | Methods and devices for endovascular mitral valve correction from the left coronary sinus |
WO2004075789A2 (en) | 2003-02-26 | 2004-09-10 | Cook Incorporated | PROTHESIS ADAPTED FOR PLACEDd UNDER EXTERNAL IMAGING |
WO2004080352A1 (en) | 2003-03-12 | 2004-09-23 | Cook Incorporated | Prosthetic valve that permits retrograde flow |
US7381210B2 (en) | 2003-03-14 | 2008-06-03 | Edwards Lifesciences Corporation | Mitral valve repair system and method for use |
US7524332B2 (en) | 2003-03-17 | 2009-04-28 | Cook Incorporated | Vascular valve with removable support component |
JP4691017B2 (en) | 2003-03-18 | 2011-06-01 | セント ジュード メディカル インコーポレイテッド | Body tissue remodeling method and apparatus |
US7988679B2 (en) | 2003-03-18 | 2011-08-02 | Navilyst Medical, Inc. | Pressure responsive slit valve assembly for a plurality of fluids and uses thereof |
US7909862B2 (en) | 2003-03-19 | 2011-03-22 | Cook Medical Technologies Llc | Delivery systems and methods for deploying expandable intraluminal medical devices |
DE602004015261D1 (en) | 2003-03-20 | 2008-09-04 | Aortech Internat Plc Bellshill | VALVE |
CH696185A5 (en) | 2003-03-21 | 2007-02-15 | Afksendiyos Kalangos | Intraparietal reinforcement for aortic valve and reinforced valve has rod inserted in biological tissue or organic prosthesis with strut fixed to one end |
SE0300854D0 (en) | 2003-03-26 | 2003-03-26 | Oeyvind Reitan | Device for the treatment of a heart valve insufficiency |
KR100466839B1 (en) | 2003-03-28 | 2005-01-17 | 주식회사 사이언씨티 | Aortic valve Repairing Apparatus Sets and Treatment Method Using The Same |
US20060271081A1 (en) | 2003-03-30 | 2006-11-30 | Fidel Realyvasquez | Apparatus and methods for valve repair |
US20050075659A1 (en) | 2003-03-30 | 2005-04-07 | Fidel Realyvasquez | Apparatus and methods for minimally invasive valve surgery |
EP1610728B1 (en) | 2003-04-01 | 2011-05-25 | Cook Incorporated | Percutaneously deployed vascular valves |
DE602004024972D1 (en) | 2003-04-08 | 2010-02-25 | Cook Inc | INTRALUMINAL SUPPORT WITH GRAFT |
US7530995B2 (en) | 2003-04-17 | 2009-05-12 | 3F Therapeutics, Inc. | Device for reduction of pressure effects of cardiac tricuspid valve regurgitation |
US8083707B2 (en) | 2003-04-17 | 2011-12-27 | Tosaya Carol A | Non-contact damage-free ultrasonic cleaning of implanted or natural structures having moving parts and located in a living body |
US7159593B2 (en) | 2003-04-17 | 2007-01-09 | 3F Therapeutics, Inc. | Methods for reduction of pressure effects of cardiac tricuspid valve regurgitation |
US7175656B2 (en) | 2003-04-18 | 2007-02-13 | Alexander Khairkhahan | Percutaneous transcatheter heart valve replacement |
US6945996B2 (en) | 2003-04-18 | 2005-09-20 | Sedransk Kyra L | Replacement mitral valve |
US20040210240A1 (en) | 2003-04-21 | 2004-10-21 | Sean Saint | Method and repair device for treating mitral valve insufficiency |
WO2004093745A1 (en) | 2003-04-23 | 2004-11-04 | Cook Incorporated | Devices kits, and methods for placing multiple intraluminal medical devices in a body vessel |
EP1472996B1 (en) * | 2003-04-30 | 2009-09-30 | Medtronic Vascular, Inc. | Percutaneously delivered temporary valve |
US20040267357A1 (en) | 2003-04-30 | 2004-12-30 | Allen Jeffrey W. | Cardiac valve modification method and device |
US20040220654A1 (en) | 2003-05-02 | 2004-11-04 | Cardiac Dimensions, Inc. | Device and method for modifying the shape of a body organ |
US20040220657A1 (en) | 2003-05-02 | 2004-11-04 | Cardiac Dimensions, Inc., A Washington Corporation | Tissue shaping device with conformable anchors |
US20040225356A1 (en) | 2003-05-09 | 2004-11-11 | Frater Robert W. | Flexible heart valve |
EP1626681B1 (en) | 2003-05-19 | 2009-07-01 | Cook Incorporated | Implantable medical device with constrained expansion |
WO2004103223A1 (en) | 2003-05-20 | 2004-12-02 | The Cleveland Clinic Foundation | Apparatus and methods for repair of a cardiac valve |
US7179291B2 (en) | 2003-05-27 | 2007-02-20 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
CA2526110A1 (en) | 2003-05-27 | 2004-12-09 | Viacor, Inc. | Method and apparatus for improving mitral valve function |
DE602004029159D1 (en) | 2003-05-28 | 2010-10-28 | Cook Inc | |
US7041127B2 (en) | 2003-05-28 | 2006-05-09 | Ledergerber Walter J | Textured and drug eluting coronary artery stent |
US7007396B2 (en) | 2003-05-29 | 2006-03-07 | Plc Medical Systems, Inc. | Replacement heart valve sizing device |
US7351259B2 (en) * | 2003-06-05 | 2008-04-01 | Cardiac Dimensions, Inc. | Device, system and method to affect the mitral valve annulus of a heart |
TW590007U (en) | 2003-06-06 | 2004-06-01 | Univ Tamkang | Tri-leaflet mechanical heart valve |
AU2003237985A1 (en) | 2003-06-09 | 2005-01-28 | 3F Therapeutics, Inc. | Atrioventricular heart valve and minimally invasive delivery systems thereof |
US7316706B2 (en) | 2003-06-20 | 2008-01-08 | Medtronic Vascular, Inc. | Tensioning device, system, and method for treating mitral valve regurgitation |
US20040260394A1 (en) | 2003-06-20 | 2004-12-23 | Medtronic Vascular, Inc. | Cardiac valve annulus compressor system |
EP1635724A2 (en) | 2003-06-20 | 2006-03-22 | PLC Medical Systems, Inc. | Endovascular tissue removal device |
EP1648346A4 (en) | 2003-06-20 | 2006-10-18 | Medtronic Vascular Inc | Valve annulus reduction system |
US7537592B2 (en) | 2003-06-20 | 2009-05-26 | Plc Medical Systems, Inc. | Endovascular tissue removal device |
US20070093869A1 (en) | 2003-06-20 | 2007-04-26 | Medtronic Vascular, Inc. | Device, system, and method for contracting tissue in a mammalian body |
US8052751B2 (en) | 2003-07-02 | 2011-11-08 | Flexcor, Inc. | Annuloplasty rings for repairing cardiac valves |
US7201772B2 (en) | 2003-07-08 | 2007-04-10 | Ventor Technologies, Ltd. | Fluid flow prosthetic device |
WO2005007037A1 (en) | 2003-07-11 | 2005-01-27 | Vedic Biotechnology, Inc. | Selective annuloplasty for atrio-ventricular heart valve regurgitation and devices therefor |
JP4668064B2 (en) | 2003-07-14 | 2011-04-13 | キアゲン サイエンシス インコーポレイテッド | Sample presentation devices with different wettability |
NZ527025A (en) | 2003-07-16 | 2007-01-26 | David Peter Shaw | Prosthetic valves for medical application |
WO2005007018A2 (en) | 2003-07-16 | 2005-01-27 | The Regents Of The University Of California | Thin-film metal alloy biomedical implantable devices |
CA2532449C (en) | 2003-07-17 | 2013-04-16 | Corazon Technologies, Inc. | Devices and methods for percutaneously treating aortic valve stenosis |
EP1646332B1 (en) | 2003-07-18 | 2015-06-17 | Edwards Lifesciences AG | Remotely activated mitral annuloplasty system |
WO2005007036A1 (en) | 2003-07-18 | 2005-01-27 | Brivant Research & Development Limited | A device for correcting inversion of the leaflets of a leaflet valve in the heart |
US7744620B2 (en) | 2003-07-18 | 2010-06-29 | Intervalve, Inc. | Valvuloplasty catheter |
EP1653888B1 (en) | 2003-07-21 | 2009-09-09 | The Trustees of The University of Pennsylvania | Percutaneous heart valve |
AU2004259206B2 (en) | 2003-07-22 | 2009-12-17 | Corazon Technologies, Inc. | Devices and methods for treating aortic valve stenosis |
US7204255B2 (en) | 2003-07-28 | 2007-04-17 | Plc Medical Systems, Inc. | Endovascular tissue removal device |
DE10334868B4 (en) | 2003-07-29 | 2013-10-17 | Pfm Medical Ag | Implantable device as a replacement organ valve, its manufacturing process and basic body and membrane element for it |
US7951121B2 (en) * | 2003-07-30 | 2011-05-31 | Navilyst Medical, Inc. | Pressure actuated valve with improved slit configuration |
WO2005011535A2 (en) | 2003-07-31 | 2005-02-10 | Cook Incorporated | Prosthetic valve for implantation in a body vessel |
EP1659992B1 (en) | 2003-07-31 | 2013-03-27 | Cook Medical Technologies LLC | Prosthetic valve devices and methods of making such devices |
FR2858543B1 (en) | 2003-08-08 | 2006-02-03 | Assist Publ Hopitaux De Paris | AORTIC AND ANCILLARY RING FOR ITS INSTALLATION |
DE10340265A1 (en) | 2003-08-29 | 2005-04-07 | Sievers, Hans-Hinrich, Prof. Dr.med. | Prosthesis for the replacement of the aortic and / or mitral valve of the heart |
US20050049692A1 (en) | 2003-09-02 | 2005-03-03 | Numamoto Michael J. | Medical device for reduction of pressure effects of cardiac tricuspid valve regurgitation |
WO2005027797A1 (en) | 2003-09-23 | 2005-03-31 | Ersin Erek | A mitral web apparatus for mitral valve insufficiencies |
EG24012A (en) | 2003-09-24 | 2008-03-23 | Wael Mohamed Nabil Lotfy | Valved balloon stent |
US20050075725A1 (en) | 2003-10-02 | 2005-04-07 | Rowe Stanton J. | Implantable prosthetic valve with non-laminar flow |
US10219899B2 (en) | 2004-04-23 | 2019-03-05 | Medtronic 3F Therapeutics, Inc. | Cardiac valve replacement systems |
EP3821852A3 (en) | 2003-10-06 | 2021-09-22 | Medtronic 3F Therapeutics, Inc. | Minimally invasive valve replacement system |
US20050075729A1 (en) | 2003-10-06 | 2005-04-07 | Nguyen Tuoc Tan | Minimally invasive valve replacement system |
EP1711613B1 (en) | 2003-10-09 | 2013-04-10 | E.I. Du Pont De Nemours And Company | Gene silencing by using micro-rna molecules |
US7004176B2 (en) * | 2003-10-17 | 2006-02-28 | Edwards Lifesciences Ag | Heart valve leaflet locator |
CA2542658A1 (en) | 2003-10-17 | 2005-05-06 | Edwards Lifesciences Ag | Heart valve leaflet locator |
US7258698B2 (en) | 2003-10-17 | 2007-08-21 | Medtronic, Inc. | Prosthetic heart valve sizer assembly with flexible sizer body |
ITBO20030631A1 (en) | 2003-10-23 | 2005-04-24 | Roberto Erminio Parravicini | VALVULAR PROSTHETIC EQUIPMENT, IN PARTICULAR FOR HEART APPLICATIONS. |
DE10350287A1 (en) | 2003-10-24 | 2005-05-25 | Deutsche Institute für Textil- und Faserforschung Stuttgart - Stiftung des öffentlichen Rechts | Cardiovascular implant, for use as a vascular or heart valve replacement, comprises a non-resorbable polymer formed as a microfiber fleece that allows colonization by a cells |
US7347869B2 (en) | 2003-10-31 | 2008-03-25 | Cordis Corporation | Implantable valvular prosthesis |
US7070616B2 (en) | 2003-10-31 | 2006-07-04 | Cordis Corporation | Implantable valvular prosthesis |
US7416530B2 (en) | 2003-11-04 | 2008-08-26 | L & P 100 Limited | Medical devices |
WO2005046488A2 (en) | 2003-11-12 | 2005-05-26 | Medtronic Vascular, Inc. | Cardiac valve annulus reduction system |
WO2005046530A1 (en) | 2003-11-12 | 2005-05-26 | Medtronic Vascular, Inc. | Coronary sinus approach for repair of mitral valve reguritation |
WO2005048883A1 (en) | 2003-11-13 | 2005-06-02 | Fidel Realyvasquez | Methods and apparatus for valve repair |
US7740656B2 (en) | 2003-11-17 | 2010-06-22 | Medtronic, Inc. | Implantable heart valve prosthetic devices having intrinsically conductive polymers |
WO2005055811A2 (en) | 2003-12-02 | 2005-06-23 | Fidel Realyvasquez | Methods and apparatus for mitral valve repair |
AU2004296816A1 (en) | 2003-12-04 | 2005-06-23 | The Brigham And Women's Hospital, Inc. | Aortic valve annuloplasty rings |
US7186265B2 (en) | 2003-12-10 | 2007-03-06 | Medtronic, Inc. | Prosthetic cardiac valves and systems and methods for implanting thereof |
AU2004298762A1 (en) | 2003-12-16 | 2005-06-30 | Edwards Lifesciences Ag | Device for changing the shape of the mitral annulus |
US20050177228A1 (en) | 2003-12-16 | 2005-08-11 | Solem Jan O. | Device for changing the shape of the mitral annulus |
US8128681B2 (en) | 2003-12-19 | 2012-03-06 | Boston Scientific Scimed, Inc. | Venous valve apparatus, system, and method |
US7837728B2 (en) | 2003-12-19 | 2010-11-23 | Cardiac Dimensions, Inc. | Reduced length tissue shaping device |
US20050137449A1 (en) | 2003-12-19 | 2005-06-23 | Cardiac Dimensions, Inc. | Tissue shaping device with self-expanding anchors |
US7854761B2 (en) | 2003-12-19 | 2010-12-21 | Boston Scientific Scimed, Inc. | Methods for venous valve replacement with a catheter |
US7794496B2 (en) | 2003-12-19 | 2010-09-14 | Cardiac Dimensions, Inc. | Tissue shaping device with integral connector and crimp |
US20050137450A1 (en) | 2003-12-19 | 2005-06-23 | Cardiac Dimensions, Inc., A Washington Corporation | Tapered connector for tissue shaping device |
US7261732B2 (en) | 2003-12-22 | 2007-08-28 | Henri Justino | Stent mounted valve |
US7959666B2 (en) | 2003-12-23 | 2011-06-14 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
US8246675B2 (en) | 2003-12-23 | 2012-08-21 | Laboratoires Perouse | Kit for implanting in a duct |
US9526609B2 (en) | 2003-12-23 | 2016-12-27 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US8182528B2 (en) | 2003-12-23 | 2012-05-22 | Sadra Medical, Inc. | Locking heart valve anchor |
EP3300692B1 (en) | 2003-12-23 | 2019-06-19 | Boston Scientific Scimed, Inc. | Repositionable heart valve |
US7381219B2 (en) | 2003-12-23 | 2008-06-03 | Sadra Medical, Inc. | Low profile heart valve and delivery system |
US7824442B2 (en) | 2003-12-23 | 2010-11-02 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
US7329279B2 (en) | 2003-12-23 | 2008-02-12 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US8343213B2 (en) | 2003-12-23 | 2013-01-01 | Sadra Medical, Inc. | Leaflet engagement elements and methods for use thereof |
US7748389B2 (en) | 2003-12-23 | 2010-07-06 | Sadra Medical, Inc. | Leaflet engagement elements and methods for use thereof |
US20050137686A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical, A Delaware Corporation | Externally expandable heart valve anchor and method |
US7166127B2 (en) | 2003-12-23 | 2007-01-23 | Mitralign, Inc. | Tissue fastening systems and methods utilizing magnetic guidance |
US8603160B2 (en) | 2003-12-23 | 2013-12-10 | Sadra Medical, Inc. | Method of using a retrievable heart valve anchor with a sheath |
US7780725B2 (en) | 2004-06-16 | 2010-08-24 | Sadra Medical, Inc. | Everting heart valve |
US20050137696A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical | Apparatus and methods for protecting against embolization during endovascular heart valve replacement |
US20050137691A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical | Two piece heart valve and anchor |
US8840663B2 (en) | 2003-12-23 | 2014-09-23 | Sadra Medical, Inc. | Repositionable heart valve method |
US20050137694A1 (en) | 2003-12-23 | 2005-06-23 | Haug Ulrich R. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US7445631B2 (en) | 2003-12-23 | 2008-11-04 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US20050149181A1 (en) | 2004-01-07 | 2005-07-07 | Medtronic, Inc. | Bileaflet prosthetic valve and method of manufacture |
US20050159810A1 (en) | 2004-01-15 | 2005-07-21 | Farzan Filsoufi | Devices and methods for repairing cardiac valves |
WO2005069850A2 (en) | 2004-01-15 | 2005-08-04 | Macoviak John A | Trestle heart valve replacement |
US7488346B2 (en) | 2004-01-21 | 2009-02-10 | The Cleveland Clinic Foundation | Method and apparatus for replacing a mitral valve and an aortic valve with a single homograft |
WO2005070342A1 (en) | 2004-01-22 | 2005-08-04 | Australian Surgical Design & Manufacture Pty Ltd | Heart valve |
US7871435B2 (en) | 2004-01-23 | 2011-01-18 | Edwards Lifesciences Corporation | Anatomically approximate prosthetic mitral heart valve |
US7320705B2 (en) | 2004-01-23 | 2008-01-22 | James Quintessenza | Bicuspid pulmonary heart valve and method for making same |
US7597711B2 (en) | 2004-01-26 | 2009-10-06 | Arbor Surgical Technologies, Inc. | Heart valve assembly with slidable coupling connections |
US20050203818A9 (en) | 2004-01-26 | 2005-09-15 | Cibc World Markets | System and method for creating tradeable financial units |
US7572289B2 (en) | 2004-01-27 | 2009-08-11 | Med Institute, Inc. | Anchoring barb for attachment to a medical prosthesis |
JP4403183B2 (en) | 2004-02-05 | 2010-01-20 | チルドレンズ・メディカル・センター・コーポレイション | Transcatheter delivery of replacement heart valves |
US7311730B2 (en) | 2004-02-13 | 2007-12-25 | Shlomo Gabbay | Support apparatus and heart valve prosthesis for sutureless implantation |
EP1727499B1 (en) | 2004-02-20 | 2012-06-13 | Cook Medical Technologies LLC | Prosthetic valve with spacing member |
US8430925B2 (en) | 2004-02-27 | 2013-04-30 | Cardiacmd, Inc. | Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same |
US7395130B2 (en) | 2004-02-27 | 2008-07-01 | Micron Technology, Inc. | Method and system for aggregating and combining manufacturing data for analysis |
US7717930B2 (en) | 2004-02-27 | 2010-05-18 | Cook Incorporated | Valvulotome with a cutting edge |
US20050203549A1 (en) | 2004-03-09 | 2005-09-15 | Fidel Realyvasquez | Methods and apparatus for off pump aortic valve replacement with a valve prosthesis |
AU2005221234C1 (en) | 2004-03-11 | 2009-10-29 | Percutaneous Cardiovascular Solutions Pty Limited | Percutaneous heart valve prosthesis |
US7942927B2 (en) | 2004-03-15 | 2011-05-17 | Baker Medical Research Institute | Treating valve failure |
US20050203605A1 (en) | 2004-03-15 | 2005-09-15 | Medtronic Vascular, Inc. | Radially crush-resistant stent |
US7449027B2 (en) | 2004-03-29 | 2008-11-11 | Cook Incorporated | Modifying fluid flow in a body vessel lumen to promote intraluminal flow-sensitive processes |
US20050228494A1 (en) | 2004-03-29 | 2005-10-13 | Salvador Marquez | Controlled separation heart valve frame |
US7993397B2 (en) | 2004-04-05 | 2011-08-09 | Edwards Lifesciences Ag | Remotely adjustable coronary sinus implant |
US20060013855A1 (en) * | 2004-04-05 | 2006-01-19 | Medivas, Llc | Bioactive stents for type II diabetics and methods for use thereof |
US20050222675A1 (en) | 2004-04-06 | 2005-10-06 | Sauter Joseph A | Implantable prosthetic heart valve comprising a valve body and a tubular vascular graft |
US8349001B2 (en) | 2004-04-07 | 2013-01-08 | Medtronic, Inc. | Pharmacological delivery implement for use with cardiac repair devices |
EP1737390A1 (en) | 2004-04-08 | 2007-01-03 | Cook Incorporated | Implantable medical device with optimized shape |
US7582110B2 (en) | 2004-04-13 | 2009-09-01 | Cook Incorporated | Implantable frame with variable compliance |
US20050240202A1 (en) | 2004-04-21 | 2005-10-27 | Hani Shennib | Devices and methods of repairing cardiac valves |
US20060025857A1 (en) * | 2004-04-23 | 2006-02-02 | Bjarne Bergheim | Implantable prosthetic valve |
US20050240255A1 (en) | 2004-04-23 | 2005-10-27 | Schaeffer Darin G | Carrier-Based Delivery System for Intraluminal Medical Devices |
US7641686B2 (en) | 2004-04-23 | 2010-01-05 | Direct Flow Medical, Inc. | Percutaneous heart valve with stentless support |
US7951196B2 (en) | 2004-04-29 | 2011-05-31 | Edwards Lifesciences Corporation | Annuloplasty ring for mitral valve prolapse |
US20050244460A1 (en) | 2004-04-29 | 2005-11-03 | Ivan Alferiev | Biodegradable crosslinking strategies using triglycidyl amine (TGA) |
US7374573B2 (en) | 2004-05-03 | 2008-05-20 | Shlomo Gabbay | System and method for improving ventricular function |
US20050256566A1 (en) | 2004-05-03 | 2005-11-17 | Shlomo Gabbay | Apparatus and method for improving ventricular function |
US8012201B2 (en) * | 2004-05-05 | 2011-09-06 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with multiple chamber formed in place support |
WO2005107646A1 (en) | 2004-05-06 | 2005-11-17 | Cook Incorporated | Delivery system that facilitates visual inspection of an intraluminal medical device |
US20060122686A1 (en) | 2004-05-10 | 2006-06-08 | Ran Gilad | Stent and method of manufacturing same |
US20060122692A1 (en) | 2004-05-10 | 2006-06-08 | Ran Gilad | Stent valve and method of using same |
US20060122693A1 (en) | 2004-05-10 | 2006-06-08 | Youssef Biadillah | Stent valve and method of manufacturing same |
US20060095115A1 (en) | 2004-05-10 | 2006-05-04 | Youssef Bladillah | Stent and method of manufacturing same |
EP3398522B1 (en) * | 2004-05-14 | 2019-12-25 | Evalve, Inc. | Locking mechanisms for fixation devices |
US20060074485A1 (en) | 2004-05-17 | 2006-04-06 | Fidel Realyvasquez | Method and apparatus for percutaneous valve repair |
US7803182B2 (en) | 2004-05-28 | 2010-09-28 | Cordis Corporation | Biodegradable vascular device with buffering agent |
US7785615B2 (en) | 2004-05-28 | 2010-08-31 | Cordis Corporation | Biodegradable medical implant with encapsulated buffering agent |
GB0414099D0 (en) | 2004-06-23 | 2004-07-28 | Univ Glasgow | Biocompatible layered structures and methods for their manufacture |
US7361190B2 (en) | 2004-06-29 | 2008-04-22 | Micardia Corporation | Adjustable cardiac valve implant with coupling mechanism |
AU2005260008B2 (en) | 2004-06-29 | 2009-07-16 | The Cleveland Clinic Foundation | Prosthetic cardiac valve and method for making same |
US7276078B2 (en) * | 2004-06-30 | 2007-10-02 | Edwards Lifesciences Pvt | Paravalvular leak detection, sealing, and prevention |
US7462191B2 (en) * | 2004-06-30 | 2008-12-09 | Edwards Lifesciences Pvt, Inc. | Device and method for assisting in the implantation of a prosthetic valve |
EP1781179A1 (en) | 2004-07-06 | 2007-05-09 | Baker Medical Research Institute | Treating valvular insufficiency |
US7513864B2 (en) * | 2004-07-09 | 2009-04-07 | Kantrowitz Allen B | Synchronization system between aortic valve and cardiac assist device |
US7167746B2 (en) * | 2004-07-12 | 2007-01-23 | Ats Medical, Inc. | Anti-coagulation and demineralization system for conductive medical devices |
EP1768611A4 (en) * | 2004-07-15 | 2009-11-18 | Micardia Corp | Implants and methods for reshaping heart valves |
US8034102B2 (en) * | 2004-07-19 | 2011-10-11 | Coroneo, Inc. | Aortic annuloplasty ring |
US7422607B2 (en) | 2004-08-24 | 2008-09-09 | Oviatt Henry W | Anti-calcification treatments for heart valves and vascular grafts |
JP2008510587A (en) | 2004-08-26 | 2008-04-10 | クック インコーポレイテッド | Delivery device with controlled friction characteristics |
AU2005280145A1 (en) | 2004-08-27 | 2006-03-09 | Cook Incorporated | Placement of multiple intraluminal medical devices within a body vessel |
CA2578706A1 (en) | 2004-09-01 | 2006-03-16 | Cook Incorporated | Delivery system which facilitates hydration of an intraluminal medical device |
US7566343B2 (en) | 2004-09-02 | 2009-07-28 | Boston Scientific Scimed, Inc. | Cardiac valve, system, and method |
FR2874813B1 (en) | 2004-09-07 | 2007-06-22 | Perouse Soc Par Actions Simpli | VALVULAR PROSTHESIS |
US20060052867A1 (en) | 2004-09-07 | 2006-03-09 | Medtronic, Inc | Replacement prosthetic heart valve, system and method of implant |
CN1745727A (en) | 2004-09-08 | 2006-03-15 | 王蓉珍 | Intercurrent artificial heart valve, its implanting and recovering device |
US7361189B2 (en) | 2004-09-10 | 2008-04-22 | Cook Incorporated | Prosthetic valve with pores |
JP2008513060A (en) | 2004-09-14 | 2008-05-01 | エドワーズ ライフサイエンシーズ アーゲー | Device and method for treatment of heart valve regurgitation |
WO2006034245A2 (en) | 2004-09-20 | 2006-03-30 | Cardiac Dimensions, Inc. | Percutaneous mitral valve annuloplasty delivery system |
US20060064174A1 (en) | 2004-09-22 | 2006-03-23 | Reza Zadno | Implantable valves and methods of making the same |
US7850704B2 (en) | 2004-09-27 | 2010-12-14 | Theranova, Llc | Method and apparatus for anchoring implants |
US6951571B1 (en) | 2004-09-30 | 2005-10-04 | Rohit Srivastava | Valve implanting device |
US20060074483A1 (en) | 2004-10-01 | 2006-04-06 | Schrayer Howard L | Method of treatment and devices for the treatment of left ventricular failure |
CA2583591C (en) | 2004-10-02 | 2018-10-30 | Christoph Hans Huber | Methods and devices for repair or replacement of heart valves or adjacent tissue without the need for full cardiopulmonary support |
WO2006041972A2 (en) | 2004-10-06 | 2006-04-20 | Cook Incorporated | Medical device with bioactive agent |
US20060085060A1 (en) | 2004-10-15 | 2006-04-20 | Campbell Louis A | Methods and apparatus for coupling an allograft tissue valve and graft |
WO2006050459A2 (en) | 2004-10-28 | 2006-05-11 | Cook Incorporated | Methods and systems for modifying vascular valves |
US7458987B2 (en) | 2004-10-29 | 2008-12-02 | Cook Incorporated | Vascular valves having implanted and target configurations and methods of preparing the same |
US7641687B2 (en) | 2004-11-02 | 2010-01-05 | Carbomedics Inc. | Attachment of a sewing cuff to a heart valve |
EP1811894A2 (en) | 2004-11-04 | 2007-08-01 | L & P 100 Limited | Medical devices |
US20060100697A1 (en) | 2004-11-10 | 2006-05-11 | Casanova R M | Shape memory annuloplasty ring and holder |
US20060167468A1 (en) | 2004-11-12 | 2006-07-27 | Shlomo Gabbay | Implantation system and method for loading an implanter with a prosthesis |
EP1830747A2 (en) | 2004-11-19 | 2007-09-12 | Medtronic, Inc. | Method and apparatus for treatment of cardiac valves |
US7744642B2 (en) | 2004-11-19 | 2010-06-29 | Biomedical Research Associates, Inc. | Prosthetic venous valves |
US20060135967A1 (en) | 2004-11-22 | 2006-06-22 | Fidel Realyvasquez | Method and apparatus for attaching a valve prosthesis |
US20060161249A1 (en) | 2004-11-22 | 2006-07-20 | Fidel Realyvasquez | Ring-shaped valve prosthesis attachment device |
US20060111774A1 (en) | 2004-11-24 | 2006-05-25 | Samkov Alexander V | Low noise heart valve prosthesis and method for operation |
US20060116572A1 (en) | 2004-12-01 | 2006-06-01 | Case Brian C | Sensing delivery system for intraluminal medical devices |
US20060161248A1 (en) | 2004-12-01 | 2006-07-20 | Case Brian C | Medical device with leak path |
EP1827551A1 (en) | 2004-12-06 | 2007-09-05 | SurModics, Inc. | Multifunctional medical articles |
EP1819304B1 (en) | 2004-12-09 | 2023-01-25 | Twelve, Inc. | Aortic valve repair |
US20060127443A1 (en) | 2004-12-09 | 2006-06-15 | Helmus Michael N | Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery |
US7211110B2 (en) | 2004-12-09 | 2007-05-01 | Edwards Lifesciences Corporation | Diagnostic kit to assist with heart valve annulus adjustment |
US7410497B2 (en) | 2004-12-14 | 2008-08-12 | Boston Scientific Scimed, Inc. | Stimulation of cell growth at implant surfaces |
SE0403046D0 (en) | 2004-12-15 | 2004-12-15 | Medtentia Ab | A device and method for improving the function of a heart valve |
US20060178700A1 (en) | 2004-12-15 | 2006-08-10 | Martin Quinn | Medical device suitable for use in treatment of a valve |
JP2008523923A (en) | 2004-12-16 | 2008-07-10 | ルイス,カルロス | Separable sheath and method for inserting medical device into body tube using separable sheath |
US7758640B2 (en) | 2004-12-16 | 2010-07-20 | Valvexchange Inc. | Cardiovascular valve assembly |
EP1830748A4 (en) | 2004-12-16 | 2008-06-04 | Carlos Ruiz | A heart valve and method for insertion of the heart valve into a bodily vessel |
WO2006069094A1 (en) | 2004-12-20 | 2006-06-29 | Cook Incorporated | Intraluminal support frame and medical devices including the support frame |
US7575594B2 (en) | 2004-12-30 | 2009-08-18 | Sieracki Jeffrey M | Shock dampening biocompatible valve |
DE102005003632A1 (en) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Catheter for the transvascular implantation of heart valve prostheses |
ITTO20050074A1 (en) | 2005-02-10 | 2006-08-11 | Sorin Biomedica Cardio Srl | CARDIAC VALVE PROSTHESIS |
US7914569B2 (en) * | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
WO2008097589A1 (en) | 2007-02-05 | 2008-08-14 | Boston Scientific Limited | Percutaneous valve, system, and method |
US9848981B2 (en) | 2007-10-12 | 2017-12-26 | Mayo Foundation For Medical Education And Research | Expandable valve prosthesis with sealing mechanism |
US8696743B2 (en) | 2008-04-23 | 2014-04-15 | Medtronic, Inc. | Tissue attachment devices and methods for prosthetic heart valves |
JP5607639B2 (en) | 2008-10-10 | 2014-10-15 | サドラ メディカル インコーポレイテッド | Medical devices and systems |
US8945209B2 (en) | 2011-05-20 | 2015-02-03 | Edwards Lifesciences Corporation | Encapsulated heart valve |
WO2013009975A1 (en) | 2011-07-12 | 2013-01-17 | Boston Scientific Scimed, Inc. | Coupling system for medical devices |
CA2957442C (en) | 2011-08-11 | 2019-06-04 | Tendyne Holdings, Inc. | Improvements for prosthetic valves and related inventions |
CN104039272A (en) | 2011-11-15 | 2014-09-10 | 波士顿科学国际有限公司 | Medical device with keyed locking structures |
EP4049626A1 (en) | 2011-12-09 | 2022-08-31 | Edwards Lifesciences Corporation | Prosthetic heart valve having improved commissure supports |
US9277993B2 (en) | 2011-12-20 | 2016-03-08 | Boston Scientific Scimed, Inc. | Medical device delivery systems |
US9757232B2 (en) | 2014-05-22 | 2017-09-12 | Edwards Lifesciences Corporation | Crimping apparatus for crimping prosthetic valve with protruding anchors |
US9788942B2 (en) | 2015-02-03 | 2017-10-17 | Boston Scientific Scimed Inc. | Prosthetic heart valve having tubular seal |
-
2005
- 2005-09-21 US US11/232,403 patent/US7569071B2/en active Active
-
2006
- 2006-09-18 CA CA2623321A patent/CA2623321C/en active Active
- 2006-09-18 WO PCT/US2006/036266 patent/WO2007038047A2/en active Application Filing
- 2006-09-18 EP EP06803779.5A patent/EP1945141B1/en active Active
-
2007
- 2007-01-11 US US11/652,299 patent/US20070129788A1/en not_active Abandoned
-
2009
- 2009-07-27 US US12/509,604 patent/US7951189B2/en active Active
-
2011
- 2011-05-27 US US13/117,770 patent/US8460365B2/en not_active Expired - Fee Related
-
2012
- 2012-04-24 US US13/454,778 patent/US8672997B2/en active Active
-
2013
- 2013-06-10 US US13/913,830 patent/US20130274865A1/en not_active Abandoned
-
2015
- 2015-10-07 US US14/877,182 patent/US9474609B2/en active Active
-
2016
- 2016-10-05 US US15/286,025 patent/US10548734B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040186563A1 (en) * | 2003-03-18 | 2004-09-23 | Lobbi Mario M. | Minimally-invasive heart valve with cusp positioners |
US20040260389A1 (en) * | 2003-04-24 | 2004-12-23 | Cook Incorporated | Artificial valve prosthesis with improved flow dynamics |
US7429269B2 (en) * | 2003-07-08 | 2008-09-30 | Ventor Technologies Ltd. | Aortic prosthetic devices |
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US10154901B2 (en) | 2008-02-26 | 2018-12-18 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
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Also Published As
Publication number | Publication date |
---|---|
WO2007038047A3 (en) | 2008-08-21 |
US20170020672A1 (en) | 2017-01-26 |
US20120209378A1 (en) | 2012-08-16 |
US7951189B2 (en) | 2011-05-31 |
US8672997B2 (en) | 2014-03-18 |
EP1945141A2 (en) | 2008-07-23 |
US20070129788A1 (en) | 2007-06-07 |
US8460365B2 (en) | 2013-06-11 |
US20110230949A1 (en) | 2011-09-22 |
WO2007038047A2 (en) | 2007-04-05 |
US7569071B2 (en) | 2009-08-04 |
EP1945141B1 (en) | 2017-10-25 |
US20070067021A1 (en) | 2007-03-22 |
CA2623321C (en) | 2014-09-16 |
US10548734B2 (en) | 2020-02-04 |
US20160022421A1 (en) | 2016-01-28 |
US9474609B2 (en) | 2016-10-25 |
CA2623321A1 (en) | 2007-04-05 |
US20100005658A1 (en) | 2010-01-14 |
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Legal Events
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