US20130006272A1 - Sealing Clip, Delivery Systems, and Methods - Google Patents
Sealing Clip, Delivery Systems, and Methods Download PDFInfo
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- US20130006272A1 US20130006272A1 US13/540,794 US201213540794A US2013006272A1 US 20130006272 A1 US20130006272 A1 US 20130006272A1 US 201213540794 A US201213540794 A US 201213540794A US 2013006272 A1 US2013006272 A1 US 2013006272A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
- A61B17/0644—Surgical staples, i.e. penetrating the tissue penetrating the tissue, deformable to closed position
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00637—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for sealing trocar wounds through abdominal wall
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00646—Type of implements
- A61B2017/00663—Type of implements the implement being a suture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00646—Type of implements
- A61B2017/00668—Type of implements the implement being a tack or a staple
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- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
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- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Surgical Instruments (AREA)
Abstract
A sealing clip for sealing or holding punctures or openings in tissue closed is applied from the inner surface of the tissue. A delivery apparatus is used to releasably hold the clip in one configuration for introduction of the clip through the puncture or opening and expand the clip to a more open configuration for pulling the clip through the tissue as the delivery apparatus is retracted. Further retraction of the delivery apparatus causes the edges of the tissue surrounding the opening to move along the clip and come together after which the clip is released and closed to hold the tissue edges of the opening together. In the case where the clip has a memory set closed shape, the clip returns toward that shape after being released to hold the tissue edges of the opening together, thereby holding the opening closed.
Description
- The present invention relates generally to the field of surgical devices and more particularly to surgical devices and methods for sealing perforations in body organs or vessels.
- An ever increasing number of diagnostic and interventional surgical procedures are performed using catheters introduced into the body at one or a few entry sites. By limiting the number and size of incisions, patients are able to recover more quickly and with less discomfort. With the wide range of catheters at their disposal, surgeons can operate or perform diagnostics on a great number of bodily systems, including but not limited to the vascular, nervous, and reproductive systems. Following these procedures the catheters and various accessories are removed, leaving one or more puncture sites which must be closed. These sites are often difficult to suture because they are on internal tissues or organs, are located on arterial walls below the skin, or are only accessible by a catheter. The present invention relates to procedures in which physicians do not have direct access to the tissue surrounding an opening in arterial walls or other biological tissue walls using suture.
- As an example of the type of puncture closing that is problematic, consider interluminal procedures performed on the vascular system, such as an angiogram or angioplasty. The skin is punctured through to the femoral artery, and an introducer sheath is placed in the puncture. For interluminal vascular procedures, the introducer sheath is a tube having a lumen and an outer diameter in the range of 2 mm (6 F on the french catheter scale) to 15 mm (45 F) or more. Catheters are inserted through the introducer sheath and threaded towards the heart or other vascular site of interest. At the conclusion of the procedure, the catheter is removed, followed by the removal of the introducer sheath. Bleeding at the puncture site has conventionally been controlled by the use of manual compress upstream from the puncture site. Achieving homeostasis with manual compression, however, is time consuming and can result in complications. Generally, compression must be applied for one-half hour or more to achieve hemostasis. If anticoagulants are used, it may take an additional 2 to 4 hours for the effects of the anticoagulants to wear off and for compression to be effective. Direct complications from manual compression include occlusion of underlying blood vessels, which can lead to ischemia and/or thrombosis. In general, the problems and patient discomfort increase with introducer sheath size and the use of anticoagulants.
- Various attempts to achieve hemostasis without the problems associated with manual compression have been made. Many of the attempts involved facilitating vessel closure using tools compatible with ancillary devices used with catheter procedures. Complicated remote controlled mechanisms for suturing are inserted through the introducer sheath following catheter removal, for example. These attempts have included the use of collagen plugs to seal the puncture, the use of complicated, remote controlled mechanisms for suturing, the application of fasteners such as hooks, clips, or staples applied from the exterior of an artery. While each of these devices can be used for closing a puncture more rapidly than manual compression, other problems can result from their use. For example, suturing devices may require many cooperating moving parts to pass the suture from one side of the artery to the other, as well as knot pushers for pushing knotted sutures or mechanisms for knot tying. Collagen plugs do not avoid all blood loss, and may increase the risk of thrombosis formation and the development of an inflammatory autoimmune reaction. Closing punctures using fasteners often involves the use of excessive force in the area surrounding their application, which can cut off or greatly reduce blood flow to the adjacent areas. This can cause ischemia and impair the healing process.
- In addition many locations where closing is required are not easily visible, resulting in difficulty in placing the fastener, collagen plug, or any of the other devices described above.
- Minimally invasive surgery, especially minimally invasive surgery using robotic techniques, presents further problems for known fastening techniques. In minimally invasive surgery, the surgeon has access to the body through small openings and often must work in restricted spaces or cavities. However, many known techniques are not compatible with minimally invasive techniques.
- For procedures where incisions or punctures are internal to the body or percutaneous, the conventional hemostasis methods of choice are sutures and fasteners, which are usually staples. It is important that the puncture closing device work rapidly and accurately, and that it does not subject the vessels (e.g., arteries) to any undue force. The use of any of the available devices or methods can result in problems and lead to complications with the surgical procedure, which can delay patient recovery or jeopardize the patient's health. Therefore, there is a need for improved devices and methods for closing punctures or other openings in bodily tissue or organs following surgery.
- The present invention involves methods and apparatus for closing and/or sealing tissue openings that overcome disadvantages of the prior art. The invention is particularly useful for closing and/or sealing tissue openings in situations where access to the opening is limited, such as in minimally invasive surgery.
- According to one embodiment of the invention, a surgical clip is provided comprising an elongated member and a pair of biasing mechanisms coupled to the member, the elongated member comprising shape memory material and having a memory set closed configuration from which it is moveable to a plurality of open configurations, the biasing mechanisms being selectively adjustable to bias the clip toward any of the plurality of open configurations. With this construction, the clip can be introduced through an opening in tissue and expanded so that its ends are directed toward the inner surface of the tissue adjacent the opening and pulled therethrough. After the clip is pulled through the tissue surrounding the opening so that the clip bridges the opening, the tissue and/or clip can be manipulated so that the tissue slides along the clip to the central region of the clip, thereby approximating the tissue edges surrounding the opening. The ability to apply the fastener from the interior area of the tissue to the exterior area of the tissue without sutures and accompanying knot tying steps is advantageous. The clip can then be allowed to return toward its memory set configuration where it can hold the tissue edges together and seal the opening. Further, the biasing mechanisms can be symmetrically arranged about the elongated member. This can enhance the ability to accurately position the clip ends beneath the tissue adjacent the opening.
- According to another embodiment of the invention, a surgical clip is provided comprising an elongated member and a pair of biasing mechanisms coupled to the member, the elongated member comprising shape memory material and having a memory set closed configuration from which it is moveable to a plurality of open configurations, the biasing mechanisms being selectively adjustable to bias the clip toward any of the plurality of open configurations, each biasing mechanism comprising a biasing member and an actuator, each biasing member adapted to apply a biasing force to the elongated member to urge the elongated member away from the closed configuration, and each actuator being coupled to one of the biasing members and adapted to activate the biasing member to apply the biasing force to the elongated member.
- According to another embodiment of the invention, a surgical clip is provided comprising an elongated member and a pair of biasing mechanisms coupled to the member, the elongated member comprising shape memory material and having a memory set closed configuration from which it is moveable to a plurality of open configurations, the biasing mechanisms being selectively adjustable to bias the clip toward any of the plurality of open configurations, the elongated member further having two tissue piercing members secured to and engaging said elongated member and extending therefrom.
- According to another embodiment of the invention, a surgical clip is provided comprising an elongated member and a pair of biasing mechanisms coupled to the member, the elongated member comprising shape memory material and having a memory set closed configuration from which it is moveable to a plurality of open configurations, the biasing mechanisms being selectively adjustable to bias the clip toward any of the plurality of open configurations, the elongated member further having two tissue piercing members integrally formed therewith.
- According to another embodiment of the invention, a delivery mechanism is provided to deliver the clip through a tissue opening, open the clip, move the clip through tissue adjacent the opening so that the clip bridges the opening and the tissue edges surrounding the opening can be approximated, and release the clip. In addition, the delivery apparatus may optionally remove piercing members at the clip ends. In one variation, a surgical clip delivery apparatus is provided for delivering a surgical clip comprising an elongated member and a pair of biasing mechanisms coupled to the member, the elongated member comprising shape memory material and having a memory set closed configuration from which it is moveable to a plurality of open configurations, the biasing mechanisms being selectively adjustable to bias the clip toward any of the plurality of open configurations, each biasing mechanism comprising a biasing member and an actuator, each biasing member adapted to apply a biasing force to the elongated member to urge the elongated member away from the closed configuration, and each actuator being coupled to one of the biasing members and adapted to activate the biasing member to apply the biasing force to the elongated member, the apparatus comprising a body member having an opening adapted to allow the surgical clip to pass therethrough for release thereof; a clip holder disposed in the body member and adapted to releasably hold the surgical clip; and a controller having multiple actuator engaging surfaces disposed in the body member, the multiple surfaces configured to engage the clip actuators to adjust the force that the biasing member applies to the clip.
- According to another embodiment of the invention, a surgical system is provided for closing an opening in tissue, the system comprising a self-closing clip, a body member, a clip holder, and a controller; the self-closing clip comprising an elongated member and a pair of biasing mechanisms coupled to the member, the elongated member comprising shape memory material and having a memory set closed configuration from which it is moveable to a plurality of open configurations, the biasing mechanisms being selectively adjustable to bias the clip toward any of the plurality of open configurations, each biasing mechanism comprising a biasing member and an actuator, each biasing member adapted to apply a biasing force to the elongated member to urge the elongated member away from the closed configuration, and each actuator being coupled to one of the biasing members and adapted to activate the biasing member to apply the biasing force to the elongated member; the body member having an opening adapted to allow said surgical clip to pass therethrough for release thereof; the clip holder disposed in said body member and adapted to releasably hold said surgical clip; and the controller having multiple actuator engaging surfaces disposed in said body member, said multiple surfaces configured to engage said clip actuators to adjust the force that the biasing member applies to said clip.
- According to another embodiment of the invention, a surgical system is provided for closing an opening in tissue comprising and elongated body member and a surgical clip; the elongated body member having a proximal end and a distal end adapted for introduction into a tissue opening, the elongated body member further having an opening therein; and the surgical clip having ends, an open configuration and a closed configuration, the surgical clip being releasably coupled to the elongated body member and arranged so that when in said open configuration the clip ends extend from the body member opening at diametrically opposed portions of the body member and generally point toward the proximal end of the body member so that when the body member is introduced into the tissue opening and the surgical clip moved to the open configuration, the ends of the surgical clip can penetrate the tissue adjacent the opening therein when the body member is retracted.
- According to another embodiment of the invention, a method is provided for closing an opening in tissue having an outer surface and an inner surface comprising introducing a self-closing clip, which has ends, an open configuration and a memory set closed configuration, through the opening; positioning the self-closing clip in an open configuration with the ends directed toward the inner surface of the tissue; passing the ends through the tissue adjacent to the opening; closing the opening; and allowing the self-closing clip to return toward its closed configuration.
- The above is a brief description of some deficiencies in the prior art and advantages of the present invention. Other features, advantages, and embodiments of the invention will be apparent to those skilled in the art from the following description and accompanying drawings, wherein, for purposes of illustration only, specific forms of the invention are set forth in detail.
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FIGS. 1A to 1E diagrammatically illustrate a clip sealing a vessel opening according to the present invention, whereFIG. 1A shows the vessel opening,FIG. 1B shows a clip placed within the vessel, in accordance with the present invention, prior to insertion through the vessel wall,FIG. 1C shows the clip in an open position placed about the vessel opening,FIG. 1D shows an optional step of removing piercing members at the ends of the clip prior to closing the clip, andFIG. 1E shows the clip in a closed configuration holding the vessel opening closed and sealing the vessel; -
FIGS. 2A , 2B, 2C, 2D, and 2E present several cross-sectional views through the vessel corresponding to those indicated inFIG. 1A to 1E ; -
FIG. 3 illustrates a perspective view, including cut-away sections, of one embodiment of a clip delivery apparatus of the present invention; -
FIGS. 4A to 4E illustrate one embodiment of a clip of the present invention, whereFIG. 4A shows a top plan view of the clip in an open configuration,FIG. 4B shows the clip ofFIG. 4A in an intermediate configuration, andFIG. 4C shows the clip ofFIG. 4B in a closed configuration, and whereFIGS. 4D andFIG. 4E are partial cross-sectional views of the clip; -
FIGS. 5A to 5C illustrate further clip embodiments having piercing members at the clip ends for insertion into tissue, whereFIG. 5A is a top plan view of the clip in an open configuration,FIG. 5B is a cross-sectional view of removable piercing member, andFIG. 5C is a cross-sectional view of a piercing member configuration where the piercing member is fixedly secured to a portion of the clip; -
FIG. 6 is an exploded perspective view of a clip release mechanism of the present invention usable with the clip delivery apparatus ofFIG. 3A ; -
FIG. 7 is an assembled perspective view of the clip release mechanism ofFIG. 6 with the clip ofFIG. 6 releasably coupled thereto; -
FIGS. 7A and 7B are further views of the clip release mechanism ofFIG. 7 , whereFIG. 7A illustrates the release mechanism lockingly engaging or holding the clip andFIG. 7B illustrates the release mechanism releasing the clip; -
FIGS. 8A to 8E are sequential diagrammatic views of the clip delivery apparatus and clip release mechanism ofFIGS. 3 , 6 and 7 being used to seal a wound, whereFIG. 8A shows the clip in a partially open configuration within the delivery apparatus for introduction into a vessel opening,FIG. 8B shows the clip being retracted in the delivery apparatus into a more open configuration,FIG. 8C shows the clip fully opened and partially extending from the delivery apparatus,FIG. 8D shows the fully opened clip seated in the tissue, andFIG. 8E shows the clip released from the delivery apparatus, fully deployed and in a closed configuration; -
FIG. 9 is a perspective view of another embodiment of a clip delivery apparatus of the present invention, including a piercing member removal mechanism; -
FIGS. 10A and 10B are retracted and extended views, respectively, of the distal end of the apparatus ofFIG. 9 , showing a clip removal mechanism in a retracted and deployed position; -
FIG. 10C is a front view of the apparatus ofFIG. 10B ; -
FIGS. 11A to 11E diagrammatically illustrate the clip delivery apparatus ofFIG. 9 sealing a tissue opening with a clip having removable piercing members, whereFIG. 11A shows the clip coupled to the clip delivery apparatus and placed through a vessel opening and within the vessel prior to piercing the vessel wall,FIG. 11B shows the deployed piercing member removal mechanism,FIG. 11C shows the clip after it has pierced the tissue and with the piercing members inserted into the deployed piercing member removal mechanism,FIG. 11D shows the clip with the piercing members removed, andFIG. 11E shows the clip detached from the clip delivery apparatus and in a closed configuration in the vessel tissue; -
FIGS. 12A to 12C show a mesh embodiment of the piercing member removal mechanism intercepting portion in use, whereFIG. 12A shows the clip with piercing member approaching the mesh,FIG. 12B shows the piercing member being forced through the mesh, andFIG. 12C shows the piercing member passed through the mesh and removed from the clip; and -
FIGS. 13A to 13C show another embodiment of the piercing member removal mechanism intercepting portion in use, whereFIG. 13A shows the clip with the piercing member approaching the intercepting portion,FIG. 13B shows the piercing member being forced through the intercepting portion, andFIG. 13C shows the piercing member retained by the intercepting portion, which impedes or precludes withdrawal of the piercing member. - Before the present invention is described, it is to be understood that this invention is not limited to the particular embodiments or examples described, as such may, of course, vary. Further, when referring to the drawings, like numerals indicate like elements.
- The present invention provides an apparatus and method for sealing punctures or other openings in bodily tissues and is both effective and compatible with many of the tools and techniques employed in minimally invasive surgery. Although the invention will be described in connection with sealing percutaneous punctures to the femoral artery or to the aorta following bypass surgery as an aid in achieving hemostasis, it should be understood that it has other applications. It may be used or adapted to be used on other bodily tissues or organs to facilitate hemostasis of other types of wounds, openings or punctures as would be apparent to those skilled in the art.
- According to one aspect of the invention, a surgical fastener or clip, such as a self-closing clip, is introduced through a tissue opening, which can be made percutaneaously or by other known means such as minimally invasive means, positioned below the opening, and manipulated to pass through the tissue edges surrounding the opening where the tissue edges are then brought together along the clip. The clip is then closed to hold the tissue edges of the opening together.
- Referring to
FIGS. 1A-E and 2A-E, an exemplary diagrammatic illustration of one embodiment of the invention is shown.FIGS. 1A-E show perspective views andFIGS. 2A-E show corresponding cross-sectional views of a vessel opening closure method using a fastener or clip generally designated withreference numeral 10. As shown,clip 10 is used to facilitate closing the opening by piercing the vessel wall from the inside of the vessel as will be described in more detail below. - The illustrative diagrammatic example shows artery A having an arterial lumen or interior I and an arterial wall W with a perforation or opening O to be closed. The opening O may be a percutaneous opening formed in an artery A, where the opening has been made through the skin and tissue (not shown) surrounding the artery. Alternatively, the surgeon can incise the artery to form the opening as part of a minimally invasive surgical procedure or other procedure where access to the opening is limited. Returning to the figures,
Clip 10 is shown with two ends and piercingmembers 12 removably attached thereto. Further,clip 10 can be arranged in at least two configurations: an open configuration 20 (FIGS. 2B-D ) and a closed configuration 30 (FIG. 2E ).Open configuration 20 is used to allow piercingmembers 12 to pierce wall W as shown inFIGS. 1B-C and 2B-C. After the tissue is moved along the clip to close the opening as shown inFIGS. 1E and 2E , the clip is allowed to return to itsclosed configuration 30, where it holds the tissue edges together.Clip 10 is delivered to the interior of artery A and then placed inopen configuration 20 with piercingmembers 12 pointed towardwall W. Clip 10 can be held or restrained inopen configuration 20, by components integral to or removable from the clip and/or components coupled to the clip as will be discussed in more detail below. Withclip 10 inopen configuration 20, piercingmembers 12 are pushed through wall W on opposite sides of opening O, as shown inFIGS. 1C and 2C . After insertion through wall W, piercingmembers 12 can be removed fromclip 10 if desired, as shown inFIGS. 1D and 2D . Under some conditions the removal of piercingmembers 12 is not required or possible, and they may be left attached to clip 10. The surgeon brings the tissue edges together along the clip with the surgeon's fingers or an instrument such as a clip delivery apparatus described below.Clip 10 is then closed or allowed to self-close, when a self-closing clip is used, and return to or assumeclosed configuration 30, which can be a loop configuration, thereby securing or holding together the opposing sides or tissue edges ofopening 0. - According to another aspect of the invention, clip delivery apparatus can be provided to facilitate the placement and/or closure of the clip. For example, such a delivery apparatus can be provided to hold
clip 10 to introduce it to the site of opening O either through the interior I along artery A, or through the opening O. The delivery apparatus can, for example, deliver the clip through the opening when closing a puncture following minimally invasive procedures. In such a procedure, access to the body interior is achieved by maintaining a tissue opening through the placement of a cannula or sheath through a tissue puncture. During the procedure, various catheters and other instruments are placed through the cannula or sheath. At the conclusion of the procedure, the instruments and cannula or sheath are withdrawn, and the puncture is then closed. In many instances, the puncture is percutaneous or has otherwise restricted access. Thus, use of a clip delivery apparatus that can be inserted into the puncture prior to cannula removal and that can seal the opening after cannula removal is compatible with minimally invasive procedures. - Referring to
FIG. 3 , one embodiment of a clip delivery apparatus is shown in accordance with the invention. As noted above, the apparatus can be delivered through a cannula in a minimally invasive procedure.FIG. 3 is a perspective view ofclip delivery apparatus 300 for delivering a clip to a desired site.Delivery apparatus 300 extends from aproximal end 309 to adistal end 305, and includes a sheath or tubularouter body member 301 having anouter knob 304 near the proximal end, and an inner member 303 (which can be a solid or tubular rod) extending substantially along the length of the delivery apparatus and having aninner knob 306 secured thereto or formed therewith at the proximal end of the apparatus. - A
slot 307 bisects a distal portion ofsheath 301 in a longitudinal direction and extends along diametrically opposed portions or sides of the distal end portion of the sheath.Delivery apparatus 300 provides for the delivery of a clip throughslot 307 through actuation ofinner knob 306 and/orouter knob 304.Outer knob 304 is connected tosheath 301 nearproximal end 309 by, for example, welding or gluing, or it is formed therewith so thatouter knob 304 can be used to axially translate or rotatesheath 301 along or aboutinner member 303.Inner knob 306 is connected toinner member 303 such as by welding or gluing, or it can be formed therewith. In turn, the distal end ofinner member 303 is coupled to a clip holding and release mechanism or it can form part of such a mechanism. The clip holding and release mechanism facilitates delivering a clip to a target site and deploying it. One clip holding and release mechanism is shown inFIGS. 6-8 in accordance with one aspect of the invention. Withknob 306 secured toinner member 303,knob 306 can be used by an operator or surgeon to axially translate or rotateinner member 303 relative tosheath 301 to actuate the clip holding and release mechanism and load a clip in or deploy a clip fromapparatus 300. -
Delivery apparatus 300 has a generally cylindrical shape that terminates in a curved or blunt distal end portion. This shape facilitates the use of the device to remotely place clips through surgical openings in a body and release the clips fromdistal end 305. Althoughslot 307 is shown bisectingsheath 301, other configuration that allow the clip to pass therethrough with the open ends of the clip sufficiently spaced to bridge the opening can be used. - One embodiment of a clip constructed in accordance with the present invention and suitable for use with clip delivery apparatus 300 (or
clip delivery apparatus 900 described below) is illustrated inFIGS. 4A-4F and designated withreference numeral 410.Clip 410 includes anelongated member 401, having anouter surface 423, and multiple biasingmechanisms 405, which include coils or biasingmembers 407 and rings ordisks 409.Disks 409 also may be referred to as actuators as they activate biasing members or coils 407 when forced thereagainst.Clip 410 is symmetric in thatclip member 401, clip ends orrestraint members 403 and biasingmechanisms 405 are symmetrically positioned about axis A, which bisects the U-shaped clip as shown, for example, inFIG. 4A . The symmetric aspect enhances one's ability to symmetrically open the clip and/or accurately position the clip ends through the desired portions of the target tissue so that the clip bridges the opening. For example, the clip can be positioned to bridge diametrically opposed portions of the opening. - In general,
clip 410 comprises ashape memory member 401, which can have a closed memory set configuration as shown for example inFIG. 4F , and coils or biasingmembers 407 positioned therearound to urge or bias the clip member toward an open configuration when the coils are compressed. Clips comprising shape memory members surrounded by coils that move toward an open configuration when the coils are compressed are described in the following U. S. Patent, Patent Applications, and Patent Publications all of which are incorporated herein in their entirety: U.S. Pat. No. 6,514,265, application Ser. Nos. 09/090,305 and 09/089,884, both entitled Tissue Connector Apparatus and Methods and filed Jun. 3, 1998, and Ser. No. 09/260,623, entitled Tissue Connector Apparatus and Methods, and Ser. No. 09/259,705, entitled Tissue Connector Apparatus With Cable Release, both filed Mar. 1, 1999, and U.S. Patent Application Publication Nos. 2002-0010490, entitled Tissue Connector Apparatus and Methods, and 2001-0018592, entitled Bridge Clip Tissue Connector Apparatus and Methods. Also incorporated herein are PCT publications WO 99/62409, which and corresponds to International Application No. PCT/US99/12563, which claims priority to the above mentioned Ser. Nos. 09/090,305 and 09/259,705, and WO 99/62406, which corresponds to International Application No. PCT/US99/12566, which claims priority to above mentioned Ser. Nos. 09/089,884 and 09/260,623. Both WO 99/62409 and WO 99/62406 published on Dec. 9, 1999. - According to one embodiment,
clip member 401 comprises adeformable wire 401 made of shape memory alloy or superelastic material. A nickel titanium (nitinol) based alloy may be used, for example. The nitinol may include additional elements which affect the yield strength of the material or the temperature at which particular pseudoelastic or shape transformation characteristics occur. The transformation temperature may be defined as the temperature at which a shape memory alloy finishes transforming from martensite to austenite upon heating (i.e., Af temperature). The shape memory alloy preferably exhibits pseudoelastic (superelastic) behavior when deformed at a temperature slightly above its transformation temperature. At least a portion of the shape memory alloy is converted from its austenitic phase to its martensitic phase when the wire is in its deformed configuration. As the stress is removed, the material undergoes a martensitic to austenitic conversion and springs back to its original undeformed configuration. - When
clip 410 is positioned in tissue and allowed to return toward its closed state, a residual stress is present inmember 401 to maintain the tissue tightly together. In order for the pseudoelastic member orwire 401 to retain sufficient compression force in this configuration, it should not be stressed past its yield point in its deformed delivery or open configuration to allow full tendency toward its undeformed configuration. The shape memory alloy can be selected so as to be suitable with the application. For example, it can be selected with a transformation temperature suitable for use with a stopped heart condition where cold cardioplegia has been injected for temporary paralysis of the heart tissue (e.g., temperatures as low as 8-10 degrees Celsius). - It is to be understood that the shape memory alloy may also be heat activated, or a combination of heat activation and pseudoelastic properties may be used, as is well known by those skilled in the art.
- The cross-sectional diameter of the member or
wire 401 and the length ofmember 401 will vary depending on the specific application. The diameter of member orwire 401 may be, for example, between about 0.001 and 0.015 inch. For percutaneous vascular applications, the diameter is preferably between about 0.001 and 0.008 inch with a diameter “D” of the loop ofmember 401 withcoils 407 thereon is between about 0.0125 and 0.0875 inch (FIG. 4C ). The diameter “D” of the loop formed bymember 401 in its closed position is preferably sized to prevent movement between adjacent tissues. Althoughmember 401 is shown with a circular cross-sectional shape (see e.g.,FIG. 4E ), it is to be understood thatmember 401 may have other cross-sectional shapes such as rectangular or elliptical, or it may be formed from multiple strands. - The wire (e.g., wire 401) may be formed in the shape illustrated in
FIG. 4F by first wrapping the wire onto a mandrel and heat treating the wire at approximately 400-500 degrees Celsius for approximately 5 to 30 minutes. The wire is then air quenched at room temperature. The coil can be formed from any suitable material such as platinum alloy, nitinol, or stainless steel wire with a diameter of about 0.0005-0.005 inch. - Returning to
FIG. 4A , eachbiasing mechanism 405 includes a helical compression spring orcoil 407, having aninner surface 419 and anouter surface 417, and a ring ordisk 409. Each compression spring extends from one of arespective restraint 403 to one of the pair of rings ordisks 409. Eachrestraint 403 can form an end ofmember 401. Further, the materials for rings ordisks 409 and clip member ends 403 are chosen primarily to be biocompatible and rigid. Suitable materials include platinum alloy, nitinol, or stainless steel. The restraints can be integrally formed withclip member 401 or formed fromclip member 401 by, for example, physically working the ends ofmember 401 to form an enlarged portion or thermally or chemically treating the ends ofclip member 401 to form an enlarged portion. Alternatively, the restraints can be separately formed and secured to an end ofmember 401 such as by welding, gluing or swaging. Each restraint is configured to prevent arespective spring 407 from sliding thereover and offmember 401. In the illustrative embodiment, each end orrestraint member 403 is in the form of a spherical ball that is sized with a diameter greater than that of the respective end portions of spring orcoil 407 adjacent thereto. It should be understood thatrestraints 403 can have other shapes that present a restraining face to the ends ofsprings 407 as well, including, but not limited to cylindrical shapes having a diameter greater than that of the ends ofsprings 407, elliptical or conical shapes having such a diameter, button shapes and T shapes. - Referring to
FIGS. 4A & B, the length of the visible portion ofmember 401 is designated with reference character S This visible portion is located between the pair ofrings 409, while the balance of the length ofmember 401 is obscured by eithersprings 407 or rings 409, and is hidden from view. -
Coils 407 and rings ordisks 409 are adapted and/or arranged to slide alongclip member 401 while transmitting a biasing force to clip member ends 403. This can be seen in the cross-sectional details shown inFIGS. 4D & E. Eachspring 407 has afirst end 411 that seats against one of the clip member ends 403 and asecond end 413 that seats against one ofrings 409, specifically against aspring seating surface 415. The inner diameter of each spring is greater than the outer diameter ofclip member 401 so that the spring can slide alongmember 401. Similarly each ofrings 409 has ahole 425 with a diameter larger than the diameter ofclip member 401 so that the rings can slide alongmember 401.FIG. 4C shows eachspring 407 in contact with a corresponding one ofrestraints 403 and a corresponding one ofrings 409. The inner surface of the springs or rings may touch various portions ofclip member 401 depending on the size ofmember 401, coils 407 and rings 409 and the configuration of the clip. Althoughclip 410 has been shown and described as being symmetrical, it need not necessarily be symmetrical. Examples of variations that can be used include providing a clip member that is not symmetrical between clip ends 403, providing clip ends 403 that differ from each other in size and/or shape, and providing biasingmembers 405 that includesprings 407 of differing size and/or length. Still other variations include providing clip ends or restraints that differ in composition or method of attachment and/or springs 407 having different spring constants or any combination of the variations described above. It also should be understood that these variations are provided for purposes of example and that other variations also can be made without departing from the scope of the invention. - Returning to
FIGS. 4A and 4B , biasingmembers 405 individually impart forces onclip member 401 to openclip member 401. As more force is applied to clip 401, it tends to move toward a more open configuration. In the illustrative embodiment, rings ordisks 409 are slidably mounted overclip member 401 and present inner andouter surfaces respective springs 407. As one applies force toouter surfaces 417 ofrings 409, theinner surfaces 415 ofrings 409, which are in contact with the spring, move spring ends 413 toward clip ends orrestraints 403, which interface with spring ends 411. Asrings 409 move toward clip ends orrestraints 403, coils or springs 407 are compressed betweenrings 409 andrestraints 403. Thus, for example, one can increase the bias force F to increase the clip length betweenrings 409 and increase spring compression. Alternatively, a forcing mechanism, such as the apparatus shown inFIG. 7 , can be used to moverings 409 away from one another to compresssprings 407 andopen clip 410. - Three clip configurations and a schematic representation of the bias forces are shown in
FIGS. 4A-4C for decreasing amounts of bias force. The mostopen configuration 410A (FIG. 4A ) has a bias force F equal to F1, creating a visible clip length S betweenrings 409 equal to S1 and causing clip ends 403 to have a spacing X therebetween equal to X1. Anintermediate configuration 410B (FIG. 4B ) has a smaller bias force F equal to F2 (where F2<F1), a visible clip length S equal to S2 (where S2<S1), and clip member ends 403 with a spacing therebetween X equal X2 (where X2<X1). Aclosed configuration 410C (FIG. 4C ) has an even smaller bias force F equal to F3 (where F3<F2) and the visible clip length S equal to S3 (where S3<S2). Inclosed configuration 410C (FIG. 4C ) ends 403 cross, forming aloop 427 in the central portion ofclip 410. In this configuration, S3 is zero and the spring force (F3) is greater or equal to zero.FIG. 4F illustratesclip member 401 in its memory shape and without biasingmembers 405. Although particular visible lengths S ofclip member 401 or spacings betweenrings 409, clip member end spacings X, and biasing forces F, as well as various clip configurations are shown, it should be understood that variations may be had without departing from the scope of the invention. - Referring to
FIGS. 5A-5C , another clip embodiment is shown and generally indicated withreference numeral 510.Clip 510 has anopen configuration 410A,intermediate configuration 410B andclosed configuration 410C, and is the same asclip 410 with the exception that clip 510 further includes a pair of piercingmembers 501, which as illustrated can be conical.Further clip 510 may or may not include enlarged ends 403. Each piercingmember 501 includes atip 503 constructed for piercing tissue and can be formed from, fixedly secured to, or releasably coupled toclip member 401.FIGS. 5B and 5C show two different versions ofclip 510 whereFIG. 5B illustrates a piercing member that is releasably coupled toclip member 401 andFIG. 5C illustrates a piercing member that is fixedly attached to clipmember 401. - Referring to
FIG. 5B , aclip 510′ is shown according to one embodiment of the invention with a removable piercingmember 501′ that is releasably coupled to clip end orrestraint 403. Piercingmember 501′, which can be conical, has aflexible receiving end 505 for receiving anend 403 ofmember 401. Receivingend 505 has a chamber or cavity formed therein for receiving arespective clip end 403. The diameter of the chamber opening in the receivingend 505 of each piercingmember 501′ is smaller than a diameter of the enlarged clip end such that the clip end may be readily snapped into and out of the piercing member. Each removable piercing member also can have a thinned cross-section adjacent to the opening formed therein to enhance the ability to releasably snap the clip end into and out of the tissue piercing member. When the clip end is spherical, the opening in receivingend 505 can be circular with a diameter that is slightly smaller than the diameter of the spherical clip end. When other clip end shapes are used, the opening is suitably configured to mate therewith and facilitate a similar snap fit so that the clip end can be releasably locked in the tissue piercing member. - Referring to
FIG. 5C , aclip 510″ is shown according to another embodiment of the invention with a piercingmember 501″ fixedly attached to the end ofclip member 401. When a clip member having a circular cross-section is used, the end ofclip member 401 can terminate or be positioned in a cylindrical hole or bore 506 formed in piercingmember 501″. Piercingmember 501″ can be press fit, soldered, glued or otherwise attached to clipmember 401. Further, piercingmembers 501′ and 501″ can form the clip end or spring restraint member to so that each spring is compressed between a respective piercing member anddisk 409. It also should be understood that piercingmembers 501″ can be integrally formed withclip member 401 as described above. - According to another aspect of the invention, a clip holding and release mechanism is provided. The holding and release mechanism enables one to hold the clip and introduce the clip through a tissue opening, pass the clip through tissue adjacent the opening from the inner surface the tissue to the outer surface of the tissue, and to release the clip so as to allow the clip to return toward its closed configuration. The holding and release mechanism can be constructed to provide an infinite number of clip positions between the aforementioned open and closed configurations.
- Referring to
FIGS. 6 , 7, 7A and 7B, one embodiment of a clip holding and release mechanism for use withclip delivery apparatus 300 is shown and generally designated withreference numeral 600.Clip release mechanism 600 is shown in an exploded view inFIG. 6 , an assembled perspective view of inFIG. 7 , and in diagrammatic sectional views inFIGS. 7A and B. - Referring to
FIGS. 6 and 7 , clip holding andrelease mechanism 600 is placed insheath 301 of clip delivery apparatus 300 (FIG. 3 ) and can be used in conjunction withclip Clip release mechanism 600 generally comprises a body member orclip actuator controller 620, having a hole or bore 621 formed therein, and aclip holder 611 slidably mounted inbore 621. A distal end ofinner member 303 ofclip delivery apparatus 300 is secured to the proximal end ofclip holder 611, such as by welding or gluing, for proximally or distally translating the clip holder inbore 621. The distal end portion ofbody member 620 has alongitudinal slot 623 formed therein, which is aligned withslot 307 insheath 301 beforebody 620 is secured insheath 301.Slots body member 620 is secured in position insheath 301.Body 620 can be constructed to form a friction fit withsheath 301 or it can be attached to the sheath through other known means such as gluing, soldering or welding. - Body member or
controller 620 also has distally arranged or located slopedsurfaces 625, which generally form a tapered section in the distal direction and through whichslot 623 extends, and proximally arranged or locatedparallel surfaces 627 into whichslot 623 also extends.Surfaces member actuators 409 and move the clip toward an open or closed configuration as will be described in more detail below with reference toFIGS. 8A-E . Althoughslot 623 is shown as bisectingsurfaces -
Clip holder 611 comprises a spring clamp having arms which curve toward one another at the clip holderdistal end 602. When the clip holder distal end is closed, it holds the clip as shown inFIG. 7A and when it is open, it releases the clip as shown inFIG. 7B . More specifically, asclip holder 611 is moved distally inbore 621, the inner wall surfaces 650 ofbody member 620 bias the clamp to a closed or near closed position where there is no gap or an insufficient gap between the clamp arms atdistal end 602 to allow the clip (e.g., clip 510) to pass therethrough (FIG. 7A ). Asclip holder 611 is retracted or moved proximally withinbore 623 the inwardly curved portions of the clamp arms move outwardly toward their relaxed state to engageopposed walls 650, which are spaced from one another by a fixed distance generally indicated with reference numeral 652 (FIG. 7B ). This allows the gap between the arms at thedistal end 602 ofholder 611 to increase and the clip to pass therethrough. Although a fixed or constant distance between the workingwalls 650 is shown and described, other configurations can be used. For example,walls 650 can be stepped at their proximal end so as to increasedistance 652 in one step and allow the clamp arms to expand orwalls 650 can be sloped outwardly in a distal direction. In either of these examples, the clip holder arm configuration can remain as shown or other configurations can be used such as one with a 90° angle formed near the distal ends of the arms. Other variations also can be made without departing from the scope of the invention. - When loading
clip delivery apparatus 300 with a clip,clip holder 611 is moved proximally until the clamp arms ofclip holder 611 are sufficiently spaced to allow a clip, such asclip 510, to pass therethrough (see e.g.,FIG. 7 ). The clip is then introduced throughslots disks 409 positioned outside sloped or tapered surfaces 625 (FIG. 7 ) and then moved proximally through the opening between the clamp arms ends of clip holder 611 (FIG. 7B ).Clip holder 611 is then moved distally to the distal end portion ofbody 620 where the clip assumes an intermediate configuration. In this configuration, the clip delivery apparatus is ready for use. As will be described in more detail below, the sloped surfaces ofbody member 620 progressively increase or decrease the space betweenrings 409 and the parallel surfaces maintain a constant space between rings 409. Specifically, the portion ofclip member 401 located betweenrings 409 passes throughslot 623 and rings 409 seat onopposite surfaces 625. By translating the clip, such asclip 510, proximally along slopedsurface 625 towardsparallel surfaces 627, the separation betweenrings 409 increases, causing the clip to open further as shown in the progression fromFIGS. 8A to 8C . - An exemplary description of the operation of
apparatus 300 will be made with reference toFIGS. 8A-8E ,clip 510 andclip release mechanism 600 in connection with closing an opening in a femoral artery. It should be understood, however, that this example is provided for purposes of example and is not intended to limit the scope of the invention. For example, the apparatus can be used to close openings other than those in a femoral artery as set forth above. - Referring to
FIG. 8A ,clip delivery apparatus 300, havingclip 510 loaded therein and biased away from a closed configuration, is introduced through an opening in tissue T and through opening O in wall W of femoral artery A. Opening O may or may not have a cannula or sheath (not shown) placed therethrough for maintaining the opening. Specifically, the clip delivery apparatus may be placed through a tissue opening to the site of opening O, or may be placed through a cannula or sheath. It is usually the case in surgical procedures, and in particular in minimally invasive procedures that the opening O is a percutaneous opening having a trocar through which various surgical devices are provided access to artery A. In the example ofFIG. 8A , theclip delivery apparatus 300 has been inserted into the trocar (not shown), which is removed prior to sealing opening O and more specifically before the clip is opened and positioned for penetrating the tissue as shown inFIG. 8C . -
FIG. 8A shows a portion ofclip 510 positioned inslot 623 withclip 510 at the distal end portion ofbody member 620 and in a partially open or intermediate configuration.Clip delivery apparatus 300 andclip 510 is then distally translated to a predetermined penetration depth “P” into the artery as shown inFIG. 8B . The penetration depth P is sufficient to positiontips 503 ofclip 510 beneath artery wall W without touching the wall. As noted above, the depth P may be determined by markings or indicia ondelivery apparatus 300. With the delivery apparatus positioned as shown inFIG. 8B ,sheath 301 is held in place withbody member 620 secured thereto, whileinner member 303 withclip holder 611 attached thereto is retracted or proximally translated from artery A, for example, by pulling on inner knob 306 (FIG. 3A ). Sinceholder 611, which is attached toinner member 303, is releasably attached to clip 510, the clip moves proximally along slopedsurfaces 625 asclip holder 611 is retracted. This forces rings ordisks 409 against the clip coils 407 and toward the piercing ends ofclip 510 to further open the clip (FIG. 8B ).Clip holder 611 is further retracted so thatdisks 409 engageparallel surfaces 627 as shown in (FIG. 8C ), where the bias forces cause the clip to assume an open configuration with the piercing ends ready to engage the inner surface of a portion of the tissue adjacent the opening. - With
clip 510 in the open configuration as shown inFIG. 8C , clip delivery apparatus withinner member 303 andclip holder 611 is retracted or proximally translated causingclip 510 to pierce wall W and bridge the opening, e.g., on diametrically opposed sides of opening O (FIG. 8D ). With the open clip penetrated through wall W,clip holder 611 is further retracted to releaseclip 510 therefrom.Sheath 301 andinner member 303 withholder 611 are further proximally retracted together, for example, by pulling oninner knob 306 andouter knob 304 causing tissue edges surrounding the opening to slide along the clip and come together. The apparatus is further retracted causingbody member 620 to release the clip, thereby allowing the clip to move toward itsclosed configuration 410C as shown inFIG. 8E and hold or secure the tissue edges together. In this manner, the opening can be sealed. - For some types of tissue, the
clip piercing members 501 may be left in place. Examples of tissue which may not be sensitive to retaining a piercing member include stomach, bowel or colon tissue. For other types of tissue, such as coronary, aorta or other blood-carrying tissue, it may be preferable, though not necessary, to remove the piercing members for various reasons including to promote healing of the puncture site, to prevent further piercing of the tissue, or to reduce the likelihood of irritation of the tissue. In the foregoing example, which involves closure of an opening in a femoral artery, the piercingmembers 501 can be removed from the clip by cutting, or they can be removed by pulling the piercingmembers 501 off the clip when a releasably mounted piecing member configuration is used such as that shown inFIG. 5B . Various piercing member removal apparatus are described in detail below in accordance with further aspects of the invention. - Referring to
FIG. 9 ,clip delivery apparatus 900, which includes a piercing member removal mechanism in accordance with another embodiment of the invention, is shown. More specifically,clip delivery apparatus 900 is the same asclip delivery apparatus 300 with the exception of having a piercing member removal apparatus incorporated therein. -
Delivery apparatus 900 extends from aproximal end 909 to adistal end 905, and includes a sheath or tubularouter member 901 having anouter knob 904 near the proximal end, and an inner member 903 (which can be a solid or tubular rod) extending substantially along the length of the delivery apparatus and having aninner knob 906 secured thereto or formed therewith at the proximal end of the apparatus. - A
slot 907, which is the same asslot 307, bisects a distal portion ofsheath 901 in a longitudinal direction and extends along diametrically opposed portions or sides of the distal end portion of the sheath.Delivery apparatus 900 provides for the delivery of a clip throughslot 907 through actuation ofinner knob 906 and/orouter knob 904 as discussed above in connection withdelivery apparatus 300. Specifically,outer knob 904 is connected tosheath 901 nearproximal end 909 by, for example, welding or gluing or it is formed therewith so thatouter knob 904 can be used to axially translate or rotatesheath 901 along or aboutinner member 903.Inner knob 906 is connected toinner member 903 such as by welding or gluing. In turn, the distal end ofinner member 903 is coupled to a clip holding and release mechanism or it can form part of such a mechanism such as the clip holding and release mechanism described above with reference toFIGS. 6-8 . Withknob 906 secured toinner member 903,knob 906 can be used by an operator or surgeon to axially translate or rotateinner member 903 relative tosheath 901 to actuate the clip holding and release mechanism and load a clip in or deploy a clip fromapparatus 900. -
Delivery apparatus 900 has a generally cylindrical shape that terminates in a curved or blunt distal end portion likedelivery apparatus 300. This shape facilitates the use of the device to remotely place clips through surgical openings in a body and release the clips fromdistal end 905. - In addition,
clip delivery apparatus 900 includes a pair of piercing member removal mechanisms and actuators for actuating the removal mechanisms, which are generally indicated withreference numeral 910. Each piercingmember removal mechanism 910 includes a pair ofsupport members 917 and piercing member intercepting or restrainingportions 919, which in the illustrative embodiment are provided at or secured to the distal end of the support members.Support members 917 can have any suitable shape for providing a support or base for interceptingportions 919. For example, eachsupport member 917 can be a flat elongated member or it can have a semi-circular, crescent, rectangular, square, or other transverse cross-sectional shape. The proximal ends ofsupport members 917 are connected to arms orrods 913, which extend proximally besidemember 303 and connect to plungerarms 911. Alternatively,arms 913 andplunger arms 911 can be integrally formed. Plunger arms 911extend through diametrically opposed slots, which are formed insheath 901 and extend in a longitudinal direction sufficiently to allowplunger arms 911 to move between two positions. In the proximal most position, plunger arms are in a fully retracted, proximal position as shown in dashed line and theremoval mechanisms 910 are retracted through openings insheath 901. In the distal most position, plunger arms are in the position shown inFIG. 9 andremoval mechanisms 910 are extended from the opening for engaging piercing members. In this manner,plunger arms 911 androds 913 actuate deployment ofremoval mechanisms 910. - Referring to
FIGS. 10A-C , one removal mechanism arrangement will be described whereFIGS. 10A and 10B illustrate retracted and extended side views of the distal end portion ofclip delivery apparatus 900 andFIG. 10C is a front view ofFIG. 10B .Removal mechanism 910 are shown in a retracted position inFIG. 10A and in a deployed position inFIG. 10B . As shown inFIG. 10C ,sheath 901 has a pair of diametrically opposed slopingportions 1003, which slope outwardly in a distal direction, andopenings 1001 at the proximal end of slopingportions 1003. When plungerarms 911 are moved distally,rods 913 andremoval mechanisms 910 are moved therewith. Piercingmember removal mechanisms 910, each having an end portion lodged between arespective opening 1001 andportion 1003 to position or guiderods 913, slide distally and outwardly alongsloping portions 1003 ofsheath 901, thereby positioning interceptingportions 919 to engage piercing members such as piercingmembers 501′.Openings 1001 and slopingsurfaces 1003 can be made by forming diametrically opposed transverse cuts intubular sheath 901 and radially compressing the sheath distally of the cuts. - Referring to
FIGS. 11A to 11E ,delivery apparatus 900 is diagrammatically shown sealing a tissue opening with a clip having removable piercingmembers 501′.FIG. 11A showsclip 510′ coupled to clipdelivery apparatus 900 and beneath opening O in vessel wall W. If a cannula or sheath had been used to surroundclip delivery apparatus 900 for insertion into opening O, it has, at this point, been retracted to allow for unimpeded operation of piercingmember removal mechanisms 910.Clip 510′ is shown in an open position with removable piercingmembers 501′ adjacent wallW. Plunger arms 911 are moved distally to deployremoval mechanisms 910 fromsheath 901 as shown inFIG. 11B . The removal mechanisms are configured and arranged so that when they are fully deployed, interceptingportions 919 oppose removable piercingmembers 501′ as shown inFIG. 11B . - Referring to
FIG. 11C ,inner member 903 is proximally translated to pull orforce clip 510′ proximally and pierce wall W in a manner similar to that shown inFIG. 8D . In addition to piercing wall W, removable piercingmembers 501′ enter or engage interceptingportions 919. Interceptingportions 919 are configured to hold or capture removable piercingmembers 501′ or to allow only one-way travel therethrough. As plunger arms 911 (not shown) are retracted to retractremoval mechanisms 917 withinsheath 901, piercingmembers 501′ are removed fromclip 510′ (FIG. 11D ).Clip delivery apparatus 900 is further retracted to approximate the tissue edges of the opening along the clip and then fully retracted from the wound site, removing piercingmembers 501′ for disposal, ejectingclip 510′ and allowingclip 510′ to move toward a closed loop configuration to hold the tissue edges together (FIG. 11E ). Although this example has been made with reference to a vessel wall and clip 510′, the apparatus can be used to seal other openings and other clips can be used. - Intercepting
portions 919 can have various configurations. Referring toFIGS. 12A to 12C , one embodiment for interceptingportion 919 is shown and generally designated withreference numeral 919′. Interceptingportion 919′ comprises a thin sheet ofmesh 1201, which is secured to the distal edge ofsupport member 917. Interceptingportion 919′ can be etched stainless steel and welded or brazed to the end ofsupport member 917.Mesh 1201 includes a plurality ofholes 1203 that are slightly smaller than the diameter of piercingmembers 501′.FIG. 12A diagrammatically illustratesclip 510′ with piercingmember 501′ approaching amesh hole 1203 andFIG. 12B shows the piercing member being forced through the mesh hole. Once piercingmember 501′ has fully passed through the mesh hole, it is not retractable due to its base having a larger diameter than that of the hole. As the removal mechanism is retracted, piercingmember 501′ is caught inmesh 1201 and removed from the clip. -
FIGS. 13A to 13C illustrate another embodiment of interceptingportion 919, which is generally designated withreference numeral 919″. Interceptingportion 919″ comprises aflap 1301 having a plurality ofslits 1302 formed therein and having a width less than the base of the piercing members for trapping a piercing member.Slits 1302 can be parallel as shown in the drawings or they can be otherwise arranged. For example, they can be arranged in parallel on a diagonal. Alternatively, they need not be arranged in parallel. Interceptingportion 919″ can be etched stainless steel and welded or brazed to the end ofsupport member 917. Interceptingportion 919″ can be formed from a single sheet of material and folded to form peak oredge 1307. Alternatively, interceptingportion 919″ can comprises twoconnected portions common edge 1307. In either case the peak is formed to extend in the same direction as approaching piercingmember 501′. This configuration assists in guiding the piercing member toward the region whereedge 1307 is formed, which can be at the center of interceptingportion 919″. Accordingly, peak 1307 can be arranged to guide the piercing member to the center of interceptingportion 919″. -
FIG. 13A showsclip 510′ with piercingmember 501′ approaching interceptingportion 919″.FIG. 13B shows the piercing member being forced through peak oredge 1307 of the flap.FIG. 13C shows the flap portions closing about the clip below the piercing member, thus resisting or precluding the piecing member from passing through the flap in the reverse or opposite direction. As the removal mechanism is retracted, interceptingportion 1301separates piercing member 501′ from the clip and the piercing member is removed with the removal mechanism. - Variations and modifications of the devices and methods disclosed herein will be readily apparent to persons skilled in the art. As such, it should be understood that the foregoing detailed description and the accompanying illustrations are made for purposes of clarity and understanding, and are not intended to limit the scope of the invention, which is defined by the claims appended hereto. Further, all publications, patents, and patent applications cited herein are hereby incorporated by reference in their entirety for all purposes.
Claims (17)
1.-15. (canceled)
16. Surgical clip delivery apparatus for delivering a surgical clip, said apparatus comprising:
a body member having an opening adapted to allow said surgical clip to pass therethrough for release thereof; a clip holder disposed in said body and adapted to releasably hold said surgical clip; and
a controller having multiple actuator engaging surfaces disposed in said body member, said multiple surfaces configured to engage said clip actuators to adjust the force that the biasing member applies to said clip.
17. The apparatus of claim 16 wherein said controller has a slot formed therein which is adapted to receive said elongated member.
18. The apparatus of claim 17 wherein said controller slot is arranged so that said actuators engage at least two of said engaging surfaces when the elongated member of said surgical clip is positioned in said slot.
19. The apparatus of claim 18 wherein said body member has a distal end and a proximal end and said body member opening comprises a slot, which is formed in said body member and extends from said distal end, said body slot being aligned with said controller slot.
20. The apparatus of claim 16 wherein said engaging surfaces include sloped surfaces.
21. The apparatus of claim 20 wherein said engaging surfaces further include parallel surfaces.
22. The apparatus of claim 16 further including tissue piercing member removal mechanisms coupled to said body member, said tissue piercing removal mechanisms having portions adapted to capture tissue piercing members when coupled to said clip.
23. A surgical system for closing an opening in tissue comprising:
a self-dosing clip as described in claim 1;
a body member having an opening adapted to allow said surgical clip to pass therethrough for release thereof;
a clip holder disposed in said body member and adapted to releasably hold said surgical clip; and
a controller having multiple actuator engaging surfaces disposed in said body member, said multiple surfaces configured to engage said clip actuators to adjust the force that the biasing member applies to said clip.
24. The system of claim 23 wherein said controller has a slot formed therein which is adapted to receive said elongated member.
25. The system of claim 24 wherein said controller slot is arranged so that said actuators engage at least two of said engaging surfaces when the elongated member of, said surgical clip is positioned in said slot.
26. The system of claim 25 wherein said body member has a distal end and a proximal end and said body member opening comprises a slot, which is formed in said body member and extends from said distal end, said body slot being aligned with said controller slot.
27. The system of claim 23 wherein said engaging surfaces include sloped surfaces.
28. The system of claim 27 said engaging surfaces further include parallel surfaces.
29. The system of claim 27 further including tissue piercing member removal mechanisms coupled to said body member, said tissue piercing removal mechanisms having portions adapted to capture tissue piercing members when coupled to said clip.
30. A surgical system for closing an opening in tissue comprising:
an elongated body member having a proximal end and a distal end adapted for introduction into a tissue opening, said elongated body member further having an opening therein; and
a surgical clip having ends, an open configuration and a closed configuration, said surgical clip being releasable’ coupled to said elongated body member and arranged so that when in said open configuration said clip ends extend from said elongated body opening at diametrically opposed portions of said body member and generally point toward the proximal end of said body member so that when said body member is introduced into the tissue opening and the surgical clip moved to said open configuration, the ends of said surgical clip can penetrate the tissue adjacent the opening-therein when the body member is retracted.
31.-38. (canceled)
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US13/540,794 US20130006272A1 (en) | 2003-07-25 | 2012-07-03 | Sealing Clip, Delivery Systems, and Methods |
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US13/540,794 US20130006272A1 (en) | 2003-07-25 | 2012-07-03 | Sealing Clip, Delivery Systems, and Methods |
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US13/540,794 Abandoned US20130006272A1 (en) | 2003-07-25 | 2012-07-03 | Sealing Clip, Delivery Systems, and Methods |
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US6607541B1 (en) * | 1998-06-03 | 2003-08-19 | Coalescent Surgical, Inc. | Tissue connector apparatus and methods |
US6613059B2 (en) | 1999-03-01 | 2003-09-02 | Coalescent Surgical, Inc. | Tissue connector apparatus and methods |
US6945980B2 (en) * | 1998-06-03 | 2005-09-20 | Medtronic, Inc. | Multiple loop tissue connector apparatus and methods |
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Also Published As
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US7182769B2 (en) | 2007-02-27 |
WO2005011468A3 (en) | 2006-03-09 |
US8211124B2 (en) | 2012-07-03 |
US20070142848A1 (en) | 2007-06-21 |
US20050021054A1 (en) | 2005-01-27 |
WO2005011468A2 (en) | 2005-02-10 |
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