US20100160792A1 - Spectroscope With Modified Field-of-View - Google Patents
Spectroscope With Modified Field-of-View Download PDFInfo
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- US20100160792A1 US20100160792A1 US12/641,811 US64181109A US2010160792A1 US 20100160792 A1 US20100160792 A1 US 20100160792A1 US 64181109 A US64181109 A US 64181109A US 2010160792 A1 US2010160792 A1 US 2010160792A1
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- spectroscope
- view
- fiber
- field
- obstruction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
Definitions
- the invention relates to spectroscopy, and in particular, to spectroscopes for detecting vulnerable plaques within a wall of a blood vessel.
- Atherosclerosis is a vascular disease characterized by a modification of the walls of blood-carrying vessels. Such modifications, when they occur at discrete locations or pockets of diseased vessels, are referred to as plaques. Certain types of plaques are associated with acute events such as stroke or myocardial infarction. These plaques are referred to as “vulnerable plaques.”
- a vulnerable plaque typically includes a lipid-containing pool of necrotic debris separated from the blood by a thin fibrous cap. In response to elevated intraluminal pressure or vasospasm, the fibrous cap can become disrupted, exposing the contents of the plaque to the flowing blood. The resulting thrombus can lead to ischemia or to the shedding of emboli.
- One method of locating vulnerable plaque is to peer through the arterial wall with infrared light. To do so, one inserts a catheter through the lumen of the artery.
- the catheter includes a delivery fiber for illuminating a spot on the arterial wall with infrared light.
- Various particles in the blood, as well as the arterial wall itself scatter or reflect much of this light.
- a small portion of the light penetrates the arterial wall, scatters off structures deep within the wall. Some of this deeply-scattered light re-enters the lumen. This re-entrant light be collected by a collection fiber within the catheter and subjected to spectroscopic analysis.
- the collection fiber preferably rejects such light and directs only re-entrant light into the collection fiber.
- the invention is based on the recognition that one can use the differing spatial distributions of specularly reflected light and re-entrant light to preferentially guide re-entrant light into the collection fiber.
- the invention includes a spectroscope having an optical fiber extending through a catheter.
- An obstruction is placed so as to occlude a portion of a field-of-view of the optical fiber.
- the obstruction includes a ledge extending across a chord of fiber core so as to occlude a region bounded by the chord and by a boundary of the core.
- the obstruction includes a tab extending at least part way across the core.
- the obstruction includes a disk disposed to occlude a circular portion of the core.
- the obstruction need not be adjacent to the fiber.
- the obstruction in spectroscopes that include a mirror in optical communication with the optical fiber, can be a non-reflective region of the mirror shaped to obstruct a portion of the fibers field-of-view.
- the obstruction can be walls forming an aperture in optical communication with the fiber, the aperture being shaped to obstruct a portion of the fibers field-of-view.
- the obstruction can be an opaque band in optical communication with the fiber and positioned to obstruct a portion of the fibers field-of-view.
- the resulting field of view of the optical fiber depends in part on the shape of the obstruction.
- the obstruction has a shape selected to form a field-of-view in the shape of a truncated ellipse. This includes the special case of a truncated circle, a circle being an ellipse with coincident foci.
- the obstruction has a shape selected to form a crescent-shaped field-of-view.
- the obstruction has a shape selected to form an annular field-of-view. Additional embodiments include those in which the obstruction has a diffracting edge, the geometry of which is selected to form a selected field-of-view.
- Another aspect of the invention includes a spectroscope having an optical fiber that extends through a catheter.
- An optical system having a finite focal length is disposed to be in optical communication with the fiber.
- the optical system includes an optical element having a curved surface.
- optical elements include mirrors and lenses.
- the curved surface can be a cylindrical surface, or it can be a paraboloid, an ellipsoid, a hyperboloid, or a sphere.
- the optical system includes an optical element with a spatially varying index of refraction.
- Another aspect of the invention includes a spectroscope having a catheter and an optical fiber extending through the catheter.
- a diffracting element configured to form a selected field-of-view is in optical communication with the fiber.
- Embodiments of the spectroscope include those in which the diffracting element is a transmissive diffracting element and those in which the diffracting element is reflective diffracting element. Other embodiments include those in which the diffracting element is a diffraction grating, an amplitude grating, a phase grating, or a holographic grating.
- FIG. 1 is a schematic of a system for identifying vulnerable plaque in a patient.
- FIG. 2 is a cross-section of the catheter in FIG. 1 .
- FIG. 3 is a view of an optical bench at the tip assembly of the catheter in FIG. 1 .
- FIG. 4 is a schematic of the paths traveled by light from the illumination fiber of FIG. 1 .
- FIG. 5 is a cross-section of the spatial light distribution shown in FIG. 4 .
- FIG. 6 is a transverse cut of the collection fiber and optical bench showing a known collection-fiber stop.
- FIG. 7 is a schematic of the field-of-view of the collection fiber of FIG. 6 superimposed on the spatial light distribution of FIG. 4 .
- FIGS. 8 and 9 are longitudinal and transverse cross-sections of an optical bench having an extended collection-fiber stop.
- FIG. 10 is a schematic of a field-of-view of resulting from the extended collection-fiber stop of FIGS. 8 and 9 .
- FIGS. 11 and 12 are longitudinal and transverse cross-sections of an optical bench having a tab protruding from the collection-fiber stop.
- FIG. 13 is a schematic of a crescent-shaped field of view resulting from the tab of FIGS. 11 and 12 .
- FIGS. 14 and 15 are longitudinal and transverse cross-sections of an optical bench having an occluding disk supported on a post protruding from the collection-fiber stop.
- FIG. 16 is a plan view of a mask on the collection mirror.
- FIG. 17 is a schematic of a perforated shell enclosing the distal tip assembly.
- FIG. 18 is a schematic of a banded sheath enclosing the distal tip assembly.
- FIG. 19 is a schematic of a mirror having a curved surface in optical communication with the collection fiber.
- FIGS. 20 and 21 are schematics of exemplary fields-of-view as modified by mirrors having various curved surfaces.
- FIG. 22 is a schematic of a lens in optical communication with the collection fiber.
- FIG. 23 is a schematic of a transmissive diffracting element in optical communication with the collection fiber.
- FIG. 24 is a schematic of a reflective diffractive element integrated onto the surface of the collection mirror.
- FIG. 1 shows a diagnostic system 10 for identifying vulnerable plaque 12 in an arterial wall 14 of a patient.
- the diagnostic system features a catheter 16 to be inserted into a selected artery, e.g. a coronary artery, of the patient.
- a delivery fiber 18 and a collection fiber 20 extend between a distal end 22 and a proximal end 24 of the catheter 16 .
- the catheter 16 includes a sheath 26 surrounding a rotatable torque cable 28 .
- the delivery fiber 18 extends along the center of a torque cable 28
- the collection fiber 20 extends parallel to, but radially displaced from, the delivery fiber 18 .
- the rotatable torque cable 28 spins at a rate between approximately 1 revolution per second and 400 revolutions per second.
- a tip assembly 30 coupled to the torque cable 28 directs light traveling axially on the delivery fiber 18 toward an illumination spot 32 on the arterial wall 14 .
- the tip assembly 30 also collects light from a field-of-view 34 on the arterial wall 14 and directs that light into the collection fiber 20 .
- a multi-channel coupler 36 driven by a motor 38 engages the proximal end 24 of the torque cable 28 .
- the motor 38 spins the multi-channel coupler 36 , both the coupler 36 , the torque cable 28 , and the tip assembly 30 spin together as a unit. This feature enables the diagnostic system 10 to circumferentially scan the arterial wall 14 with the illumination spot 32 .
- the multi-channel coupler 36 guides light from a laser 40 (or other light source such as a light-emitting diode, a super-luminescent diode, or an arc lamp) into the delivery fiber 18 and guides light emerging from the collection fiber 20 into one or more detectors (not visible in FIG. 1 ).
- a laser 40 or other light source such as a light-emitting diode, a super-luminescent diode, or an arc lamp
- the detectors provide an electrical signal indicative of light intensity to an amplifier 42 connected to an analog-to-digital (“A/D”) converter 44 .
- the A/D converter 44 converts this signal into digital data that can be analyzed by a processor 46 to identify the presence of a vulnerable plaque 12 hidden beneath the arterial wall 14 .
- FIG. 3 shows an optical bench 48 in which are seated the collection fiber 20 and the delivery fiber 18 .
- the optical bench 48 is seated in a recess 50 between first and second side walls 52 A-B of the distal end of a housing 54 .
- the housing 54 is in turn coupled to the distal end of the torque cable 28 .
- the recess 50 is just wide enough to enable the collection fiber 20 and the delivery fiber 18 to nestle adjacent to each other.
- a floor 56 extending between the first and second side walls 52 A-B and across the recess 50 supports both the collection and delivery fibers 18 , 20 .
- a portion of the optical bench 48 forms a frustum 58 .
- the frustum 58 extends transversely only half-way across the optical bench 48 , thereby enabling the collection fiber 20 to extend distally past the end of the delivery fiber 18 .
- the frustum 58 has an inclined surface facing the distal end of the delivery fiber 18 and a vertical surface facing the distal end of the optical bench 48 .
- the inclined surface forms a 135 degree angle relative to the floor 56 . Other angles can be selected depending on the direction in which light from the delivery fiber 18 is to be directed.
- a reflective material coating the inclined surface forms a beam re-director, which in this case is a delivery mirror 60 . When light exits axially from the delivery fiber 18 , the delivery mirror 60 intercepts that light and redirects it radially outward to the arterial wall 14 . Examples of other beam re-directors include prisms and diffraction gratings.
- FIG. 5 which illustrates the spatial distribution of light from the viewpoint of the catheter 16 , shows such a re-entrant zone 70 surrounding an illumination spot 32 .
- Photons received from within the re-entrant zone 70 are predominantly those that have been scattered from within the arterial wall 14 .
- the re-entrant zone 70 has an inner circumference 74 and an outer circumference 76 .
- Between the inner circumference 74 and the illumination spot 32 lies a specular zone 78 .
- Photons received from the specular zone 78 are predominantly those that have undergone specular reflection. Proceeding radially outward beyond the outer circumference 76 , one comes to a dark zone 80 , where the number of photons of either type is so small as to be immeasurable.
- the field-of-view 32 should overlap the re-entrant zone 70 to the greatest extent possible. To the extent that the field-of-view 32 extends outside the re-entrant zone 70 , it should extend into the dark zone 80 and away from the specular zone 78 .
- the collection fiber 20 extends past the end of the delivery fiber 18 until it terminates at a plane that is coplanar with the vertical face of the frustum 58 .
- a portion of the optical bench 48 forms an inclined surface extending transversely across the optical bench 48 and making a 135 degree angle relative to the floor 56 .
- a reflective material coating the inclined surface forms a collection mirror 82 .
- This collection mirror 82 reflects light incident from the arterial wall 14 into the distal end of the collection fiber 20 .
- the collection mirror 82 and the collection fiber 20 together form a collection subsystem 84 that collects light from a field-of-view 32 .
- a delivery-fiber stop 86 molded into the optical bench 48 proximal to the frustum 58 facilitates placement of the delivery fiber 18 at a desired location proximal to the delivery mirror 60 .
- a collection-fiber stop 88 molded into the optical bench 48 just proximal to the collection mirror 82 facilitates placement of the collection fiber 20 at a desired location proximal to the collection mirror 82 .
- the collection fiber has an optically transmissive core 90 surrounded by a protective cladding 92 .
- the collection-fiber stop 88 extends upward from the floor 56 to provide an abutment surface for the collection fiber 20 .
- a portion of the cladding 92 rests on the abutment surface.
- the core 90 does not rest on the abutment surface and therefore remains unobstructed.
- a distal tip assembly 94 configured as shown in FIG. 6 results in a field-of-view 32 shaped like an ellipse 96 with its major axis 98 extending along the radial direction, as shown in FIG. 7 .
- the extent to which the ellipse 96 overlaps the re-entrant zone 70 is one measure of how effective the collection subsystem 84 is at guiding re-entrant light into the collection fiber 20 .
- the extent of the overlap between the ellipse 96 and the re-entrant zone 70 depends on the eccentricity of the ellipse and its position relative to the re-entrant zone 70 .
- the eccentricity of the ellipse 96 is governed by the angular orientation of the collection mirror 82 . Its position relative to the re-entrant zone 70 is controlled by varying the position and angle of the delivery mirror 60 relative to the collection mirror 82 .
- the ellipse 96 is positioned to be tangent to the inner circumference 74 of the re-entrant zone 70 , with its minor axis 100 located radially outward from the point of tangency.
- FIGS. 8 and 9 show an extended collection-fiber stop 102 forms an abutment surface that extends part-way across the core 90 of the collection fiber.
- the occluded portion of the core 90 is bounded by a chord extending across the core 90 and by an arc that forms part of the boundary between the core 90 and the cladding 92 .
- the resulting modified field-of-view is a truncated ellipse 106 having a base 108 , as shown in FIG. 10 .
- a dotted line 110 outlines a portion 112 of the ellipse truncated by the extended collection-fiber stop 102 .
- the truncated ellipse 106 is positioned such that the base 108 of the truncated ellipse 106 is tangent to the inner circumference 74 of the re-entrant zone 70 .
- the overlap between the truncated ellipse 106 and the re-entrant zone 70 in FIG. 10 is greater than the overlap between the full ellipse 96 and the re-entrant zone 70 in FIG. 7 .
- the extent to which these overlaps differ represents an increase in the number of photons gathered from the re-entrant zone 70 .
- FIGS. 11 and 12 Other beam-shaping structures can be used to prevent light from illuminating the entire core 90 and to thereby shape the field-of-view 32 .
- a tab 118 having a curved distal tip 119 protrudes vertically upward from the collection-fiber stop 88 and obstructs part of the core 90 .
- FIGS. 14 and 15 Another example, shown in FIGS. 14 and 15 , is an occulting disk 122 mounted on a post 124 that protrudes from the collection-fiber stop 88 .
- the post 124 supports the occulting disk 122 so that its center coincides with the center of the core 90 .
- the diameter of the occulting disk 122 is slightly smaller than the diameter of the core 90 .
- the difference between the diameter of the occulting disk 122 and that of the core 90 is selected to provide an annular field-of-view that closely matches the size and shape of the re-entrant zone 70 .
- Structures that effectively block light from entering a portion of the collection fiber need not be adjacent to the collection fiber 20 , as shown in FIGS. 11-12 and in FIGS. 14-15 .
- such structures can be placed anywhere along the optical path between the collection fiber 20 and the arterial wall 14 .
- a beam-shaping structure that effectively obstructs a portion of the core 90 can be a mask 125 formed directly on the collection mirror 82 , as shown in FIG. 16 .
- Another example of such a structure is a perforated shell 127 rotationally coupled to the torque cable 28 , as shown in FIG. 17 .
- the perforated shell 127 has a delivery aperture 129 to permit light from the delivery fiber 18 to pass through the shell 127 unimpeded, and a collection aperture 131 shaped to block a portion of the light incident on the collection mirror 82 .
- an opaque band 133 on a transparent distal tip 135 of the stationary sheath 26 is positioned to obscure a portion of the collection mirror 82 .
- the band 131 extends circumferentially around the sheath so that the collection mirror 82 is obscured as the torque cable 28 rotates the collection mirror 82 .
- any of the foregoing beam-shaping structures can have an edge that is modified to diffract light incident thereon in a manner that causes the field-of-view to have a pre-selected geometry.
- Such an edge can be formed by providing protrusions or indentations having a dimension on the order of the wavelength of light to be observed.
- the beam-shaping function of the foregoing obstructions can also be achieved by providing an optical system in optical communication with the collection mirror 82 .
- Such an optical system can include a collection mirror 82 with a curved surface, a lens assembly, or both.
- the collection mirror 82 has a cylindrical surface rather than a planar surface.
- the resulting field-of-view for the configuration shown in FIG. 19 is an ellipse 126 having an aspect ratio closer to unity, as shown in FIG. 20 .
- Other curved surfaces can result in fields-of-view or alternatively an ellipse 128 in which it is the minor axis of an ellipse 128 , rather than the major axis, that extends radially, as shown in FIG. 21 .
- Curved surfaces other than a cylindrical surface can also be used to shape the field-of-view to more closely approximate the shape of the re-entrant zone 70 .
- the curved surface can be a conic surface, such as a paraboloid, a hyperboloid, or an ellipsoid.
- the surface can be a spherical surface.
- Optical elements other than reflecting surfaces can also be used to shape the field-of-view.
- a lens assembly 130 disposed in optical communication with the collection fiber 20 provides control over the shape of the field-of-view.
- the lens assembly 130 can include one or more discrete lenses.
- One or more lenses in the lens assembly can have a suitably curved surface.
- Another lens suitable for use in a lens assembly is a GRIN (graduated index of refraction) lens having a spatially varying index of refraction.
- the lens assembly 130 need not be composed of discrete lenses but can instead include a lens that is integral with the distal end of the collection fiber 20 .
- Such a lens 132 an example of which is shown in FIG. 22 , can be made by shaping the distal end of the collection fiber 20 so that it has the desired optical characteristics.
- the beam-shaping function provided by the foregoing examples of optical systems can also be provided by a diffracting element 134 placed along the optical path, as shown in FIG. 23 .
- diffracting elements 134 include diffraction gratings, amplitude gratings, spatial light modulators, and holographic gratings.
- the diffracting element can be a transmissive or reflective.
- a transmissive diffracting element 134 can be placed anywhere along the optical path traversed by the collection beam, either integrated onto the distal end of the collection fiber 20 , as shown in FIG. 23 , or mounted separately on the optical path, either between the collection fiber 20 and the mirror 82 as shown in FIG. 23 , or between the collection mirror 82 and the arterial wall.
- a reflective diffracting element 134 can be integrated directly onto the surface of the collection mirror 82 as shown in FIG. 24 .
- the surfaces of the delivery and collection mirrors 60 , 82 can be coated with a reflective coating, such as gold, silver or aluminum. These coatings can be applied by known vapor deposition techniques. Alternatively, for certain types of plastic, a reflective coating can be electroplated onto those surfaces. Or, the plastic itself can have a reflective filler, such as gold or aluminum powder, incorporated within it.
- a reflective coating such as gold, silver or aluminum.
- the optical bench 48 is manufactured by injection molding a plastic into a mold. In addition to being simple and inexpensive, the injection molding process makes it easy to integrate the elements of the optical bench 48 into a single monolith and to fashion structures having curved surfaces.
- suitable plastics include liquid crystal polymers (LCPs), polyphenylsulfone, polycarbonate, acrylonitrile butadiene-styrene (“ABS”), polyamide (“NYLON”), polyethersulfone, and polyetherimide.
- the optical bench can be manufactured by micro-machining plastic or metal, by lithographic methods, by etching, by silicon optical bench fabrication techniques, or by injection molding metal. Materials other than plastics can be used to manufacture the housing 54 and the optical bench 48 . Such materials include metals, quartz or glass, and ceramics.
- the floor 56 in the illustrated embodiment is integral to the housing 54 .
- the floor 56 can also be made part of the optical bench 48 .
- the housing 54 and the optical bench 48 are manufactured separately and later joined. However, the housing 54 and the optical bench 48 can also be manufactured together as a single unitary structure.
- the distal tip assembly 94 is inserted into a blood vessel, typically an artery, and guided to a location of interest. Light is then directed into the delivery fiber 18 . This light exits the delivery fiber 18 at its distal tip, reflects off the delivery mirror 60 in a direction away from the plane containing the delivery and collection fibers 18 , 20 , and illuminates an illumination spot 32 on the wall of the artery. Light penetrating the arterial wall 14 is then scattered by structures within the wall. Some of this scattered light re-enters the blood vessel and impinges on the plane and onto the collection mirror 82 . The collection mirror 82 directs this light into the collection fiber 20 .
- light incident on the wall 14 can stimulate fluorescence from structures on or within the wall 14 .
- the portion of this fluorescent light that is incident on the collection mirror 82 is directed into the collection fiber 20 .
Abstract
A spectroscope for detecting vulnerable plaques includes an optical fiber extending through a catheter. The optical fiber has a field-of-view that is modified to preferentially collect light scattered from deep within the wall of a blood vessel. Obstructions or curved optical surfaces can be used to modify the field of view.
Description
- The invention relates to spectroscopy, and in particular, to spectroscopes for detecting vulnerable plaques within a wall of a blood vessel.
- Atherosclerosis is a vascular disease characterized by a modification of the walls of blood-carrying vessels. Such modifications, when they occur at discrete locations or pockets of diseased vessels, are referred to as plaques. Certain types of plaques are associated with acute events such as stroke or myocardial infarction. These plaques are referred to as “vulnerable plaques.” A vulnerable plaque typically includes a lipid-containing pool of necrotic debris separated from the blood by a thin fibrous cap. In response to elevated intraluminal pressure or vasospasm, the fibrous cap can become disrupted, exposing the contents of the plaque to the flowing blood. The resulting thrombus can lead to ischemia or to the shedding of emboli.
- One method of locating vulnerable plaque is to peer through the arterial wall with infrared light. To do so, one inserts a catheter through the lumen of the artery. The catheter includes a delivery fiber for illuminating a spot on the arterial wall with infrared light. Various particles in the blood, as well as the arterial wall itself, scatter or reflect much of this light. A small portion of the light, however, penetrates the arterial wall, scatters off structures deep within the wall. Some of this deeply-scattered light re-enters the lumen. This re-entrant light be collected by a collection fiber within the catheter and subjected to spectroscopic analysis.
- Light scattered only by the blood or reflected off the vessel walls surface contains no information about structures within the wall. To the extent that such light enters the collection fiber, it represents unwanted noise. Hence, the collection fiber preferably rejects such light and directs only re-entrant light into the collection fiber.
- The invention is based on the recognition that one can use the differing spatial distributions of specularly reflected light and re-entrant light to preferentially guide re-entrant light into the collection fiber.
- In one aspect, the invention includes a spectroscope having an optical fiber extending through a catheter. An obstruction is placed so as to occlude a portion of a field-of-view of the optical fiber.
- A variety of obstructions are within the scope of the invention. For example, in some embodiments, the obstruction includes a ledge extending across a chord of fiber core so as to occlude a region bounded by the chord and by a boundary of the core. In other embodiments, the obstruction includes a tab extending at least part way across the core. In yet other embodiments, the obstruction includes a disk disposed to occlude a circular portion of the core.
- The obstruction need not be adjacent to the fiber. For example, in spectroscopes that include a mirror in optical communication with the optical fiber, the obstruction can be a non-reflective region of the mirror shaped to obstruct a portion of the fibers field-of-view. Or, for spectroscopes that include a perforated mask enclosing the fiber, the obstruction can be walls forming an aperture in optical communication with the fiber, the aperture being shaped to obstruct a portion of the fibers field-of-view. For spectroscopes that include a transparent sheath surrounding the fiber, the obstruction can be an opaque band in optical communication with the fiber and positioned to obstruct a portion of the fibers field-of-view.
- The resulting field of view of the optical fiber depends in part on the shape of the obstruction. In some embodiments, the obstruction has a shape selected to form a field-of-view in the shape of a truncated ellipse. This includes the special case of a truncated circle, a circle being an ellipse with coincident foci. In other embodiments, the obstruction has a shape selected to form a crescent-shaped field-of-view. In yet other embodiments, the obstruction has a shape selected to form an annular field-of-view. Additional embodiments include those in which the obstruction has a diffracting edge, the geometry of which is selected to form a selected field-of-view.
- Another aspect of the invention includes a spectroscope having an optical fiber that extends through a catheter. An optical system having a finite focal length is disposed to be in optical communication with the fiber.
- In some embodiments, the optical system includes an optical element having a curved surface. Examples of such optical elements include mirrors and lenses. The curved surface can be a cylindrical surface, or it can be a paraboloid, an ellipsoid, a hyperboloid, or a sphere. In other embodiments, the optical system includes an optical element with a spatially varying index of refraction.
- Another aspect of the invention includes a spectroscope having a catheter and an optical fiber extending through the catheter. In this aspect, a diffracting element configured to form a selected field-of-view is in optical communication with the fiber.
- Embodiments of the spectroscope include those in which the diffracting element is a transmissive diffracting element and those in which the diffracting element is reflective diffracting element. Other embodiments include those in which the diffracting element is a diffraction grating, an amplitude grating, a phase grating, or a holographic grating.
- Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.
- Other features and advantages of the invention will be apparent from the following detailed description, and from the claims.
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FIG. 1 is a schematic of a system for identifying vulnerable plaque in a patient. -
FIG. 2 is a cross-section of the catheter inFIG. 1 . -
FIG. 3 is a view of an optical bench at the tip assembly of the catheter inFIG. 1 . -
FIG. 4 is a schematic of the paths traveled by light from the illumination fiber ofFIG. 1 . -
FIG. 5 is a cross-section of the spatial light distribution shown inFIG. 4 . -
FIG. 6 is a transverse cut of the collection fiber and optical bench showing a known collection-fiber stop. -
FIG. 7 is a schematic of the field-of-view of the collection fiber ofFIG. 6 superimposed on the spatial light distribution ofFIG. 4 . -
FIGS. 8 and 9 are longitudinal and transverse cross-sections of an optical bench having an extended collection-fiber stop. -
FIG. 10 is a schematic of a field-of-view of resulting from the extended collection-fiber stop ofFIGS. 8 and 9 . -
FIGS. 11 and 12 are longitudinal and transverse cross-sections of an optical bench having a tab protruding from the collection-fiber stop. -
FIG. 13 is a schematic of a crescent-shaped field of view resulting from the tab ofFIGS. 11 and 12 . -
FIGS. 14 and 15 are longitudinal and transverse cross-sections of an optical bench having an occluding disk supported on a post protruding from the collection-fiber stop. -
FIG. 16 is a plan view of a mask on the collection mirror. -
FIG. 17 is a schematic of a perforated shell enclosing the distal tip assembly. -
FIG. 18 is a schematic of a banded sheath enclosing the distal tip assembly. -
FIG. 19 is a schematic of a mirror having a curved surface in optical communication with the collection fiber. -
FIGS. 20 and 21 are schematics of exemplary fields-of-view as modified by mirrors having various curved surfaces. -
FIG. 22 is a schematic of a lens in optical communication with the collection fiber. -
FIG. 23 is a schematic of a transmissive diffracting element in optical communication with the collection fiber. -
FIG. 24 is a schematic of a reflective diffractive element integrated onto the surface of the collection mirror. -
FIG. 1 shows adiagnostic system 10 for identifyingvulnerable plaque 12 in anarterial wall 14 of a patient. The diagnostic system features acatheter 16 to be inserted into a selected artery, e.g. a coronary artery, of the patient. Adelivery fiber 18 and acollection fiber 20 extend between adistal end 22 and aproximal end 24 of thecatheter 16. - As shown in
FIG. 2 , thecatheter 16 includes asheath 26 surrounding arotatable torque cable 28. Thedelivery fiber 18 extends along the center of atorque cable 28, and thecollection fiber 20 extends parallel to, but radially displaced from, thedelivery fiber 18. Therotatable torque cable 28 spins at a rate between approximately 1 revolution per second and 400 revolutions per second. - At the distal end 21 of the
catheter 16, atip assembly 30 coupled to thetorque cable 28 directs light traveling axially on thedelivery fiber 18 toward anillumination spot 32 on thearterial wall 14. Thetip assembly 30 also collects light from a field-of-view 34 on thearterial wall 14 and directs that light into thecollection fiber 20. - A
multi-channel coupler 36 driven by amotor 38 engages theproximal end 24 of thetorque cable 28. When themotor 38 spins themulti-channel coupler 36, both thecoupler 36, thetorque cable 28, and thetip assembly 30 spin together as a unit. This feature enables thediagnostic system 10 to circumferentially scan thearterial wall 14 with theillumination spot 32. - In addition to spinning the
torque cable 28, themulti-channel coupler 36 guides light from a laser 40 (or other light source such as a light-emitting diode, a super-luminescent diode, or an arc lamp) into thedelivery fiber 18 and guides light emerging from thecollection fiber 20 into one or more detectors (not visible inFIG. 1 ). - The detectors provide an electrical signal indicative of light intensity to an
amplifier 42 connected to an analog-to-digital (“A/D”)converter 44. The A/D converter 44 converts this signal into digital data that can be analyzed by aprocessor 46 to identify the presence of avulnerable plaque 12 hidden beneath thearterial wall 14. -
FIG. 3 shows anoptical bench 48 in which are seated thecollection fiber 20 and thedelivery fiber 18. Theoptical bench 48 is seated in arecess 50 between first andsecond side walls 52A-B of the distal end of ahousing 54. Thehousing 54 is in turn coupled to the distal end of thetorque cable 28. Therecess 50 is just wide enough to enable thecollection fiber 20 and thedelivery fiber 18 to nestle adjacent to each other. Afloor 56 extending between the first andsecond side walls 52A-B and across therecess 50 supports both the collection anddelivery fibers - Just distal to the end of the
delivery fiber 18, a portion of theoptical bench 48 forms afrustum 58. Thefrustum 58 extends transversely only half-way across theoptical bench 48, thereby enabling thecollection fiber 20 to extend distally past the end of thedelivery fiber 18. - The
frustum 58 has an inclined surface facing the distal end of thedelivery fiber 18 and a vertical surface facing the distal end of theoptical bench 48. The inclined surface forms a 135 degree angle relative to thefloor 56. Other angles can be selected depending on the direction in which light from thedelivery fiber 18 is to be directed. A reflective material coating the inclined surface forms a beam re-director, which in this case is adelivery mirror 60. When light exits axially from thedelivery fiber 18, thedelivery mirror 60 intercepts that light and redirects it radially outward to thearterial wall 14. Examples of other beam re-directors include prisms and diffraction gratings. - Referring to
FIG. 4 , as the light travels radially outward from thedelivery mirror 60, it encounters the blood that fills alumen 68. As a result of scattering by particles in the blood, a large number of photons never reach thewall 14. This loss of energy is shown schematically by a progressive narrowing of the beam as it nears thewall 14. The remainingphotons 61 eventually reach thearterial wall 14. Some of these photons are reflected from thewall 14. These specularly reflectedphotons 62 carry little or no information aboutstructures 64 behind thearterial wall 14 and are therefore of little value. Of thosephotons 63 that penetrate the wall, many are absorbed. Theremainder 66 are scattered bystructures 64 behind thewall 14. After having been scattered, a few of these remainingphotons 66 again pass through thearterial wall 14 and re-enter thelumen 68. This remnant of the light 61 originally incident on the wall, which is referred to herein as the “re-entrant light 66,” carries considerable information about thestructures 64 behind thearterial wall 14. It is therefore this re-entrant light 66 that is to be guided into thecollection fiber 20. - As suggested by
FIG. 4 ,re-entrant light 66 tends to re-enter the lumen along an annular re-entrant zone that is radially separated from the specularly reflectedlight 62.FIG. 5 , which illustrates the spatial distribution of light from the viewpoint of thecatheter 16, shows such are-entrant zone 70 surrounding anillumination spot 32. Photons received from within there-entrant zone 70 are predominantly those that have been scattered from within thearterial wall 14. There-entrant zone 70 has aninner circumference 74 and anouter circumference 76. Between theinner circumference 74 and theillumination spot 32 lies aspecular zone 78. Photons received from thespecular zone 78 are predominantly those that have undergone specular reflection. Proceeding radially outward beyond theouter circumference 76, one comes to adark zone 80, where the number of photons of either type is so small as to be immeasurable. - To collect as many photons of re-entrant light 66 as possible, the field-of-
view 32 should overlap there-entrant zone 70 to the greatest extent possible. To the extent that the field-of-view 32 extends outside there-entrant zone 70, it should extend into thedark zone 80 and away from thespecular zone 78. - Modifying the Field-of-View with an Obstruction
- Referring back to
FIG. 3 , thecollection fiber 20 extends past the end of thedelivery fiber 18 until it terminates at a plane that is coplanar with the vertical face of thefrustum 58. Just beyond the distal end of thecollection fiber 20, a portion of theoptical bench 48 forms an inclined surface extending transversely across theoptical bench 48 and making a 135 degree angle relative to thefloor 56. A reflective material coating the inclined surface forms acollection mirror 82. Thiscollection mirror 82 reflects light incident from thearterial wall 14 into the distal end of thecollection fiber 20. Thecollection mirror 82 and thecollection fiber 20 together form a collection subsystem 84 that collects light from a field-of-view 32. - A delivery-
fiber stop 86 molded into theoptical bench 48 proximal to thefrustum 58 facilitates placement of thedelivery fiber 18 at a desired location proximal to thedelivery mirror 60. Similarly, a collection-fiber stop 88 molded into theoptical bench 48 just proximal to thecollection mirror 82 facilitates placement of thecollection fiber 20 at a desired location proximal to thecollection mirror 82. - Referring now to
FIG. 6 , the collection fiber has an opticallytransmissive core 90 surrounded by aprotective cladding 92. The collection-fiber stop 88 extends upward from thefloor 56 to provide an abutment surface for thecollection fiber 20. A portion of thecladding 92 rests on the abutment surface. Thecore 90 does not rest on the abutment surface and therefore remains unobstructed. - A distal tip assembly 94 configured as shown in
FIG. 6 results in a field-of-view 32 shaped like anellipse 96 with itsmajor axis 98 extending along the radial direction, as shown inFIG. 7 . The extent to which theellipse 96 overlaps there-entrant zone 70 is one measure of how effective the collection subsystem 84 is at guiding re-entrant light into thecollection fiber 20. - The extent of the overlap between the
ellipse 96 and there-entrant zone 70 depends on the eccentricity of the ellipse and its position relative to there-entrant zone 70. The eccentricity of theellipse 96 is governed by the angular orientation of thecollection mirror 82. Its position relative to there-entrant zone 70 is controlled by varying the position and angle of thedelivery mirror 60 relative to thecollection mirror 82. - To avoid collecting photons from the
specular zone 78, theellipse 96 is positioned to be tangent to theinner circumference 74 of there-entrant zone 70, with itsminor axis 100 located radially outward from the point of tangency. -
FIGS. 8 and 9 show an extended collection-fiber stop 102 forms an abutment surface that extends part-way across thecore 90 of the collection fiber. The occluded portion of thecore 90 is bounded by a chord extending across thecore 90 and by an arc that forms part of the boundary between the core 90 and thecladding 92. The resulting modified field-of-view is atruncated ellipse 106 having a base 108, as shown inFIG. 10 . A dottedline 110 outlines aportion 112 of the ellipse truncated by the extended collection-fiber stop 102. To avoid collecting photons from thespecular zone 78, thetruncated ellipse 106 is positioned such that the base 108 of thetruncated ellipse 106 is tangent to theinner circumference 74 of there-entrant zone 70. - The overlap between the
truncated ellipse 106 and there-entrant zone 70 inFIG. 10 is greater than the overlap between thefull ellipse 96 and there-entrant zone 70 inFIG. 7 . The extent to which these overlaps differ represents an increase in the number of photons gathered from there-entrant zone 70. - Other beam-shaping structures can be used to prevent light from illuminating the
entire core 90 and to thereby shape the field-of-view 32. InFIGS. 11 and 12 , for example, atab 118 having a curveddistal tip 119 protrudes vertically upward from the collection-fiber stop 88 and obstructs part of thecore 90. When placed in front of acollection fiber 20 having a suitably high numerical aperture, this results in a crescent shaped field-of-view 120 as shown inFIG. 13 . - Another example, shown in
FIGS. 14 and 15 , is anocculting disk 122 mounted on apost 124 that protrudes from the collection-fiber stop 88. Thepost 124 supports theocculting disk 122 so that its center coincides with the center of thecore 90. The diameter of theocculting disk 122 is slightly smaller than the diameter of thecore 90. The difference between the diameter of theocculting disk 122 and that of thecore 90 is selected to provide an annular field-of-view that closely matches the size and shape of there-entrant zone 70. - Structures that effectively block light from entering a portion of the collection fiber need not be adjacent to the
collection fiber 20, as shown inFIGS. 11-12 and inFIGS. 14-15 . In fact, such structures can be placed anywhere along the optical path between thecollection fiber 20 and thearterial wall 14. For example, a beam-shaping structure that effectively obstructs a portion of the core 90 can be amask 125 formed directly on thecollection mirror 82, as shown inFIG. 16 . Another example of such a structure is aperforated shell 127 rotationally coupled to thetorque cable 28, as shown inFIG. 17 . Theperforated shell 127 has adelivery aperture 129 to permit light from thedelivery fiber 18 to pass through theshell 127 unimpeded, and acollection aperture 131 shaped to block a portion of the light incident on thecollection mirror 82. In another example, shown inFIG. 18 , anopaque band 133 on a transparentdistal tip 135 of thestationary sheath 26 is positioned to obscure a portion of thecollection mirror 82. Theband 131 extends circumferentially around the sheath so that thecollection mirror 82 is obscured as thetorque cable 28 rotates thecollection mirror 82. - Any of the foregoing beam-shaping structures can have an edge that is modified to diffract light incident thereon in a manner that causes the field-of-view to have a pre-selected geometry. Such an edge can be formed by providing protrusions or indentations having a dimension on the order of the wavelength of light to be observed.
- Modifying the Field-of-View with an Optical System
- The beam-shaping function of the foregoing obstructions can also be achieved by providing an optical system in optical communication with the
collection mirror 82. Such an optical system can include acollection mirror 82 with a curved surface, a lens assembly, or both. For example, inFIG. 19 , thecollection mirror 82 has a cylindrical surface rather than a planar surface. The resulting field-of-view for the configuration shown inFIG. 19 is anellipse 126 having an aspect ratio closer to unity, as shown inFIG. 20 . Other curved surfaces can result in fields-of-view or alternatively anellipse 128 in which it is the minor axis of anellipse 128, rather than the major axis, that extends radially, as shown inFIG. 21 . - Curved surfaces other than a cylindrical surface can also be used to shape the field-of-view to more closely approximate the shape of the
re-entrant zone 70. For example, the curved surface can be a conic surface, such as a paraboloid, a hyperboloid, or an ellipsoid. Alternatively, the surface can be a spherical surface. - Optical elements other than reflecting surfaces can also be used to shape the field-of-view. For example, in
FIG. 22 , alens assembly 130 disposed in optical communication with thecollection fiber 20 provides control over the shape of the field-of-view. - The
lens assembly 130 can include one or more discrete lenses. One or more lenses in the lens assembly can have a suitably curved surface. Another lens suitable for use in a lens assembly is a GRIN (graduated index of refraction) lens having a spatially varying index of refraction. In addition, thelens assembly 130 need not be composed of discrete lenses but can instead include a lens that is integral with the distal end of thecollection fiber 20. Such a lens 132, an example of which is shown inFIG. 22 , can be made by shaping the distal end of thecollection fiber 20 so that it has the desired optical characteristics. - The beam-shaping function provided by the foregoing examples of optical systems can also be provided by a diffracting
element 134 placed along the optical path, as shown inFIG. 23 . Examples of diffractingelements 134 include diffraction gratings, amplitude gratings, spatial light modulators, and holographic gratings. The diffracting element can be a transmissive or reflective. A transmissive diffractingelement 134 can be placed anywhere along the optical path traversed by the collection beam, either integrated onto the distal end of thecollection fiber 20, as shown inFIG. 23 , or mounted separately on the optical path, either between thecollection fiber 20 and themirror 82 as shown inFIG. 23 , or between thecollection mirror 82 and the arterial wall. A reflective diffractingelement 134 can be integrated directly onto the surface of thecollection mirror 82 as shown inFIG. 24 . - The surfaces of the delivery and collection mirrors 60, 82 can be coated with a reflective coating, such as gold, silver or aluminum. These coatings can be applied by known vapor deposition techniques. Alternatively, for certain types of plastic, a reflective coating can be electroplated onto those surfaces. Or, the plastic itself can have a reflective filler, such as gold or aluminum powder, incorporated within it.
- The
optical bench 48 is manufactured by injection molding a plastic into a mold. In addition to being simple and inexpensive, the injection molding process makes it easy to integrate the elements of theoptical bench 48 into a single monolith and to fashion structures having curved surfaces. Examples of suitable plastics include liquid crystal polymers (LCPs), polyphenylsulfone, polycarbonate, acrylonitrile butadiene-styrene (“ABS”), polyamide (“NYLON”), polyethersulfone, and polyetherimide. Alternatively, the optical bench can be manufactured by micro-machining plastic or metal, by lithographic methods, by etching, by silicon optical bench fabrication techniques, or by injection molding metal. Materials other than plastics can be used to manufacture thehousing 54 and theoptical bench 48. Such materials include metals, quartz or glass, and ceramics. - The
floor 56 in the illustrated embodiment is integral to thehousing 54. However, thefloor 56 can also be made part of theoptical bench 48. - As described herein, the
housing 54 and theoptical bench 48 are manufactured separately and later joined. However, thehousing 54 and theoptical bench 48 can also be manufactured together as a single unitary structure. - In use, the distal tip assembly 94 is inserted into a blood vessel, typically an artery, and guided to a location of interest. Light is then directed into the
delivery fiber 18. This light exits thedelivery fiber 18 at its distal tip, reflects off thedelivery mirror 60 in a direction away from the plane containing the delivery andcollection fibers illumination spot 32 on the wall of the artery. Light penetrating thearterial wall 14 is then scattered by structures within the wall. Some of this scattered light re-enters the blood vessel and impinges on the plane and onto thecollection mirror 82. Thecollection mirror 82 directs this light into thecollection fiber 20. - Alternatively, light incident on the
wall 14 can stimulate fluorescence from structures on or within thewall 14. The portion of this fluorescent light that is incident on thecollection mirror 82 is directed into thecollection fiber 20. - It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.
Claims (17)
1. A spectroscope comprising:
a catheter;
an optical fiber having a core and extending through the catheter, the optical fiber having a field-of-view; and
an obstruction disposed within the field-of-view of said optical fiber to prevent light in a selected zone from illuminating the core.
2. The spectroscope of claim 1 , wherein the obstruction comprises a ledge extending across a chord of the core, the ledge occluding a region bounded by the chord and by a boundary of the core.
3. The spectroscope of claim 1 , wherein the obstruction comprises a tab extending at least part way across the core.
4. The spectroscope of claim 3 , wherein the tab comprises a curved tip.
5. The spectroscope of claim 1 , wherein the obstruction comprises a disk disposed to occlude a circular portion of the field-of-view.
6. The spectroscope of claim 1 , further comprising a mirror in optical communication with the optical fiber; and wherein the obstruction comprises a non-reflective region of the mirror, the non-reflective region being shaped to obstruct a portion of the field-of-view thereof.
7. The spectroscope of claim 1 , further comprising a perforated mask enclosing the fiber; and wherein the obstruction comprises walls forming an aperture in optical communication with the fiber, the aperture being shaped to obstruct a portion of the field-of-view thereof.
8. The spectroscope of claim 1 , further comprising a transparent sheath surrounding the fiber; and wherein the obstruction comprises an opaque band in optical communication with the fiber and positioned to obstruct a portion of the field-of-view thereof
9. The spectroscope of claim 1 , wherein the obstruction has a shape selected to form a field-of-view in the shape of a truncated ellipse.
10. The spectroscope of claim 1 , wherein the obstruction has a shape selected to form a field-of-view in the shape of a crescent.
11. The spectroscope of claim 1 , wherein the obstruction has a shape selected to form an annular field-of-view.
12. The spectroscope of claim 1 , wherein the obstruction has an edge configured to diffract light incident thereon to form a selected field-of-view.
13-26. (canceled)
27. The spectroscope of claim 1 , wherein the optical fiber comprises the collection fiber.
28. The spectroscope of claim 1 , wherein the field of view includes a specular zone and a re-entrant zone.
29. The spectroscope of claim 28 , wherein the obstruction is disposed to prevent light in the specular zone from illuminating the core.
30. The spectroscope of claim 29 , wherein the obstruction is configured to prevent substantially all of the light in the specular zone from illuminating the core.
Priority Applications (1)
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US12/641,811 US20100160792A1 (en) | 2002-11-07 | 2009-12-18 | Spectroscope With Modified Field-of-View |
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US10/289,741 US20040092829A1 (en) | 2002-11-07 | 2002-11-07 | Spectroscope with modified field-of-view |
US12/641,811 US20100160792A1 (en) | 2002-11-07 | 2009-12-18 | Spectroscope With Modified Field-of-View |
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US11/772,887 Expired - Lifetime US7873406B2 (en) | 2002-11-07 | 2007-07-03 | Spectroscope for recovering light from re-entrant zone of arterial wall |
US12/641,811 Abandoned US20100160792A1 (en) | 2002-11-07 | 2009-12-18 | Spectroscope With Modified Field-of-View |
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US11/772,887 Expired - Lifetime US7873406B2 (en) | 2002-11-07 | 2007-07-03 | Spectroscope for recovering light from re-entrant zone of arterial wall |
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Also Published As
Publication number | Publication date |
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US7873406B2 (en) | 2011-01-18 |
US20040092829A1 (en) | 2004-05-13 |
JP2006505360A (en) | 2006-02-16 |
AU2003291401A1 (en) | 2004-06-03 |
US20070255142A1 (en) | 2007-11-01 |
EP1558127A4 (en) | 2008-11-26 |
JP2010142649A (en) | 2010-07-01 |
WO2004043251A1 (en) | 2004-05-27 |
EP1558127A1 (en) | 2005-08-03 |
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