US20100045934A1 - Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement - Google Patents

Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement Download PDF

Info

Publication number
US20100045934A1
US20100045934A1 US12/611,438 US61143809A US2010045934A1 US 20100045934 A1 US20100045934 A1 US 20100045934A1 US 61143809 A US61143809 A US 61143809A US 2010045934 A1 US2010045934 A1 US 2010045934A1
Authority
US
United States
Prior art keywords
eye
target
light
retina
lens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/611,438
Inventor
Daniel R. Neal
Richard James Copland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMO Wavefront Sciences LLC
Original Assignee
AMO Wavefront Sciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/692,483 external-priority patent/US6550917B1/en
Priority claimed from US10/369,513 external-priority patent/US6908196B2/en
Application filed by AMO Wavefront Sciences LLC filed Critical AMO Wavefront Sciences LLC
Priority to US12/611,438 priority Critical patent/US20100045934A1/en
Publication of US20100045934A1 publication Critical patent/US20100045934A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J9/00Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01BMEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00Measuring arrangements characterised by the use of optical techniques
    • G01B11/30Measuring arrangements characterised by the use of optical techniques for measuring roughness or irregularity of surfaces
    • G01B11/306Measuring arrangements characterised by the use of optical techniques for measuring roughness or irregularity of surfaces for measuring evenness
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01MTESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M11/00Testing of optical apparatus; Testing structures by optical methods not otherwise provided for
    • G01M11/02Testing optical properties
    • G01M11/0242Testing optical properties by measuring geometrical properties or aberrations
    • G01M11/0257Testing optical properties by measuring geometrical properties or aberrations by analyzing the image formed by the object to be tested

Definitions

  • the present invention is directed to measurement of the refractive error in the eye, more particularly to methods and techniques for compiling a topographic mapping of these refractive errors.
  • Measurements of aberrations in an eye are important for diagnosis of visual defects and assessment of acuity. These measurements and their accuracy become increasingly important in light of the growing number of ways, both surgical and non-surgical, that aberrations can be corrected. These corrections rely on accurate, precise measurements of the entire ocular system, allowing successful screening, treatment and follow-up. Enhancements in the accuracy of ocular measurements may aid in improving the identification of patients in need of correction and the performance of the correction itself.
  • objective methods for assessing the performance of the ocular system.
  • Such objective methods include corneal topography, wavefront aberrometry, corneal interferometry, and auto-refraction. Many of these methods only measure the contribution of specific elements to the total refractive error. For example, much work has been directed to measuring the topography of the cornea and characterizing the corneal layer. However, the corneal shape only contributes about 30-40% of the total refractive error in most cases. In order to measure the bulk of the refractive error and to provide a complete mapping for diagnosis and correction, additional information and measurements are needed.
  • auto-refraction Another method for determining the refraction of the eye is auto-refraction, which uses a variety of techniques to automatically determine the required corrective prescription. These automated techniques include projecting one or more spots or patterns onto the retina, automatically adjusting optical elements in the auto-refractor until the desired response is achieved, and determining the required correction from this adjustment.
  • auto-refractors are not considered especially reliable. Further, auto-refractors measure only lower order components of the aberrations, e.g., focus and astigmatic errors.
  • Wavefront aberrometry measures the full, end-to-end aberrations through the entire optics of the eye.
  • a key limitation of the instruments used in these measurements is the total resolution, which is ultimately limited by the lenslet array of the instrument.
  • selection of the lenslet array is itself limited by several factors, most importantly the size of the spot projected onto the retina.
  • FIG. 2 A schematic illustration of the basic elements of a two dimensional embodiment of a Shack-Hartmann wavefront sensor is shown in FIG. 2 .
  • a portion of an incoming wavefront 110 from the retina is incident on a two-dimensional lenslet array 112 .
  • the lenslet array 112 dissects the incoming wavefront 110 into a number of small samples.
  • the smaller the lenslet the higher the spatial resolution of the sensor.
  • the spot size from small the lenslet due to diffraction effects, limits the focal length that may be used, which in turn leads to lower sensitivity.
  • these two parameters must be balanced in accordance with desired measurement performance.
  • the image on the detector plane 114 consists of a pattern of focal spots 116 with regular spacing d created with lenslets 112 of focal length f, as shown in FIG. 3 .
  • These spots must be distinct and separate, i.e., they must be readily identifiable.
  • the spot size ⁇ cannot exceed 1 ⁇ 2 of the separation of the spots.
  • the spot separation parameter N FR can be used to characterize the lenslet array 12 and is given by:
  • N FR d ⁇ ( 1 )
  • the separation parameter can be given by:
  • the Fresnel number of the lenslet This is also known as the Fresnel number of the lenslet.
  • N FR >2.
  • the Fresnel number must be somewhat greater than two to allow for a certain dynamic range of the instrument.
  • the dynamic range of a Shack-Hartmann wavefront sensor can be defined as the limiting travel of the focal spot such that the edge of the spot just touches the projected lenslet boundary, given by:
  • the dynamic range is directly proportional to the separation parameter and the lenslet size.
  • a particularly useful arrangement for a Shack-Hartmann wavefront sensor ocular measuring system places the lenslet array in an image relay optical system at a plane conjugate to the pupil or corneal surface.
  • the spot size on the detector of the wavefront sensor is given by:
  • M is the magnification of the imaging optics
  • f L is the focal length of the lenslet array
  • f e is the focal length of the eye
  • ⁇ 1 is the spot size on the retina.
  • the sampling size of the wavefront sensor must be increased to allow even a minimal dynamic range to be realized.
  • the sample size of the wavefront sensor must be increased to allow even a minimal dynamic range to be realized.
  • the aberrations over each lenslet are sufficient to degrade the lenslet focal spot.
  • the system is limited not just by focal spot overlap, but by the fact that the focal spots themselves fade out or are difficult to track.
  • Using a small sample size does not allow sufficient light to be gathered, since the light is scattered by the retina into a large number of focal spots. Due to safety considerations, the input power may not be increased to compensate for this scattering.
  • the present invention is therefore directed to measurement of refractive errors of an eye that substantially overcomes one or more of the problems due to the limitations and disadvantages of measurements of the related art.
  • At least one of the above and other objects may be realized by providing a system for measuring errors in an eye including a projecting optical system which delivers light onto a retina of the eye, a pre-correction system which compensates a light beam to be injected into the eye for aberrations in the eye, the pre-correction system being positioned in between the projecting optical system and the eye, an imaging system which collect light scattered by the retina, and a detector receiving light from the retina collected by the imaging system.
  • the detector may be a Shack-Hartmann wavefront sensor, a shearing interferometer, a Moiré deflectometer, or other passive phase measurement systems.
  • the pre-correction system may include a telescope having at least one movable lens, fixed lenses inserted at an intermediate image plane, adaptive optical elements, and/or a cylindrical telescope.
  • the pre-correction system may correct for focus and/or astigmatism errors in the eye.
  • the telescope may be arranged so that a fixed lens of the telescope is one focal length away from the eye. Components used in the pre-correction system may also be used in the imaging system.
  • the pre-correction system may include a feedback loop which determines an appropriate pre-correction to be supplied by the pre-correction system.
  • the feedback loop may include a detector receiving light returned from the retina, a processor comparing detected light with a desired feature of the light and adjusting at least one parameter of the pre-correction system in accordance with the comparison.
  • the feedback loop may further include a return optical system for gathering the light from the retina.
  • the return optical system may include the pre-correction system.
  • the desired feature may be a minimized spot size on the retina.
  • the system may include an aperture that limits the angular dynamic range of the system.
  • the system may further include a polarizing beam splitter between the eye and the wavefront sensor.
  • the system may include an aligner that determines an appropriate eye alignment of the system.
  • the projecting optical system may provide light to the eye at an angle to a central axis of the eye.
  • the system may include an additional optical system between the detector and the eye.
  • the system may include a power monitor which monitors power of the light beam being injected in the eye.
  • the system may include an eye position detection system including a target projected on the eye, a position detector sensing the eye, and an adjustment system which adjusts a position of the system relative to the eye until the eye is in focus on the detector.
  • FIG. 1 is a schematic top view of the measurement system of the present invention
  • FIG. 2 is a schematic side view of the basic components of a Shack-Hartmann wavefront sensor
  • FIG. 3 schematically illustrates the relationship between the size of the lens, its focal length and the spot size
  • FIGS. 4A-4C schematically illustrate the spot size for different configurations
  • FIGS. 5A-5B schematically illustrate off-axis injection of the light into the eye and the blocking of the reflected light from entering the wavefront sensor
  • FIG. 6 is a schematic illustration of a configuration of the present invention using a fixed telescope and an adjustable telescope
  • FIG. 7 is a schematic illustration of a configuration of the present invention using a variable lens
  • FIG. 8 is a schematic illustration of a cylindrical telescope for use with the present invention.
  • FIG. 9 is a schematic illustration of a configuration of the present invention using a corrective lens.
  • the key to designing a practical ocular wavefront sensor system is how the light is injected into the eye. Since ocular refractive errors can be large, e.g., up to 20 diopters, the degradation of the injected beam can be significant. Further, it is difficult to design a wavefront sensor that has sufficient range to directly measure an extremely large refractive error.
  • the spot projected on the ocular system is predistorted in a manner that compensates for the eye's fundamental aberrations. This allows the spot returned to the wavefront sensor to be well formed and minimally affected by the refractive errors. The small size of the spot allows small lenslets to be used while maintaining sufficient dynamic range to measure even large, high order aberrations.
  • each focal spot is brighter than in the conventional methods. Further, the greater sampling density leads to smaller wavefront aberrations across the aperture of each lenslet.
  • the ocular wavefront measurement system shown therein generally includes a projection system for projecting light into the eye, a system for pre-correcting the injected light for ocular aberrations, a system for collecting light, a system for determining the pre-correction, and a system for measuring the collected light.
  • the projection system shown in FIG. 1 includes a light source 12 , e.g., a laser, a laser diode, LED, or a super-luminescent diode, supplied to an optical fiber 14 .
  • the light source is preferably a pulsed light source, is limited to a small power, is outside the normal visual detection range, e.g. infrared, and/or is directly collimated with an appropriate lens.
  • the optical fiber may be a polarization maintaining fiber.
  • the light leaving the optical fiber 14 is provided to a collimating lens 16 .
  • the use of an optical fiber 14 to deliver light from the light source 12 simplifies the collimating lens 16 , since the fiber exit mode acts as a diffraction-limited point source.
  • the collimating lens 16 is preferably rigidly mounted to the fiber 14 .
  • the collimated beam is then truncated to a desired size by an aperture 18 .
  • a polarizer 20 may be provided for polarizing the collimated beam.
  • a polarizing beam splitter 22 directs the light from the projection system to the rest of the ocular measuring system.
  • the light source 12 may be provided alone, i.e., without the use of the fiber 14 .
  • the light from the light source 12 itself is then collimated by a collimating lens.
  • a collimating lens While light sources used for ophthalmic measurement typically have a high degree of astigmatism, by using only a portion of the beam, e.g., 10-25%, typically from the center of the beam, the wavefront error over the beam is small enough that the beam size is substantially stable over the distance traversed in the ophthalmic measurement system. In other words, even though the beam is still astigmatic, the beam shape does not change while traversing the ophthalmic measurement system due to this astigmatism, so the astigmatism does not influence the measurement.
  • the light may be polarized as required.
  • the light from the projection system is reflected by the polarizing beam splitter 22 and directed to a pre-compensation system, shown in FIG. 1 as a telescope 30 .
  • the telescope 30 includes lenses 32 , 34 with an aperture 36 in between.
  • the telescope 30 may be adjusted by moving the lenses relative to one another. This adjustment is to provide the desired pre-correction for the injected beam by adding defocus that just compensates for the spherical equivalent defocus of the ocular system being measured.
  • the light from the telescope is directed by a beam splitter 38 to an ocular system 40 under measurement.
  • the injected beam is focused by the ocular system 40 to a focal spot 42 on the retina of the ocular system 40 . Light from this focal spot 42 is scattered or reflected by the retina.
  • the returned light is collected by the cornea and lens of the ocular system 40 and is approximately collimated.
  • the beam splitter 38 directs the beam from the ocular system back to the telescope 30 .
  • the same position of the lenses 32 , 34 of the telescope 30 corrects for the defocus aberrations of the ocular system 40 so that light arrives at a wavefront sensor 50 collimated to within the dynamic range of the sensor.
  • the aperture 36 blocks any rays outside the angular dynamic range of the wavefront sensor 50 so that no mixing or measurement confusion occurs.
  • the wavefront sensor 50 is a Shack-Hartmann sensor, the focal spots cannot collide, interfere or cause confusion with adjacent focal spots.
  • the wavefront sensor 50 may be a Shack-Hartmann wavefront sensor, a shearing interferometer, a Moiré deflectometer or any other passive phase measurement sensor.
  • the wavefront sensor 50 is a Shack-Hartmann wavefront sensor, the wavefront sensor 50 includes the elements shown in FIG. 2 .
  • the proper position of the lenses 32 , 34 of the telescope 30 may be determined in a number of ways.
  • an additional sensor 60 is used with a beam splitter 62 and a focusing lens 64 to create an image of the light incident upon the retina.
  • the proper position of the lenses 32 , 34 in the telescope 30 is determined by minimizing the spot size 42 on the back of the retina, performed by comparing the spot sizes from different positions of the lenses 32 , 34 in the telescope 30 . If the ocular system 40 is arranged to be one focal length of the objective lens 34 away from the lens 34 , then the telescope 30 will be insensitive to changes in magnification or other errors.
  • the wavefront sensor 50 should be arranged to be at the conjugate image plane to the ocular system 40 .
  • the wavefront sensor 50 , the retinal imaging sensor 60 , the projection optics 16 , 18 , 20 , the polarizing beam splitter 22 , the beam splitter 62 , and the focusing lens 64 are mounted on a platform 70 which is mounted in a moving stage 72 .
  • the use of the optical fiber 14 allows the light source to be mounted off the platform 70 , minimizing the mass of the elements moved by the translation stage 72 .
  • a processor 68 may be included to control movement of the translation stage 72 and to allow data processing, analysis and/or display.
  • a small portion of the beam incident on beam splitter 38 is transmitted to a lens 44 which focuses the light onto a power monitor 46 .
  • the output of this power monitor 46 may be used to shut down the system if the power exceeds the safety limits of the system or to alter the power supplied to the light source 12 to reduce the power output by the light source in a known manner.
  • an additional detector 80 is included. Imaging optics 82 are designed such that the iris or cornea will be in focus for only a narrow region of space.
  • a mirror 84 may be used to direct light onto the iris detector 80 .
  • the position of the system relative to the eye is adjusted until the iris or cornea is detected.
  • the detection may be indicated to a user on an indicator 86 . Preferably, this detection is used just during patient alignment and only uses a small percentage, e.g., less than 10% of the light.
  • a target 90 is made visible through a beam splitter 94 .
  • the target 90 is imaged at infinity through a lens 92 .
  • the target position may be varied by moving the target relative to the lens 92 to present targets that are either in focus or slightly out-of-focus to minimize patient accommodation. Movement of the target 90 closer to the lens 92 stimulates near vision accommodation, allowing measurement of near vision visual acuity or the target may be arranged with the image past infinity to measure distance vision.
  • the patient merely attempts to focus on the target.
  • a light source behind the target is electronically controlled to adjust the target brightness and the position of the target is also electronically adjustable.
  • the telescope 30 is used to pre-compensate the injected light and to compensate for the returned wavefront to minimize the total wavefront error incident on the wavefront sensor.
  • telescopes have been used to relay image the light onto the wavefront sensor and to compensate for strong spherical and cylindrical aberrations, but the light was injected separately. This separate handling is due to strong back reflections that occur even for lenses having anti-reflection coatings thereon. Since the returned light from the retina may be very weak, even a small reflection from the lenses can quickly dominate the measurement and saturate the wavefront sensor 50 .
  • polarized light and a polarizing beam splitter in conjunction with a quarter-wave plate may be used.
  • Off axis parabolas or other curved mirrors may be used to direct the light to the telescope.
  • the light may be injected off axis, so that any reflected light from the cornea is filtered out by the apertures of the system, as shown in FIGS. 5A and 5B .
  • FIG. 5B illustrates how the light reflected by the cornea of the eye 40 is blocked by the aperture 36 from entering the wavefront sensor and influencing the measurement. The use of one or more of these schemes is sufficient to allow pre-compensation of the injected beam in accordance with the present invention without introducing unwanted reflections.
  • a second telescope may be used in conjunction with the first telescope to increase the dynamic range by providing an alternative location for the filtering aperture.
  • one telescope can be completely fixed, while the other has a degree of freedom allowing movement until the lenses of the two telescopes are in contact.
  • FIG. 6 Such a configuration is shown in FIG. 6 , in which a fixed telescope 51 with lenses 52 , 54 and aperture 56 , is used to supply light to the wavefront sensor 50 .
  • a fixed telescope 51 with lenses 52 , 54 and aperture 56 is used to supply light to the wavefront sensor 50 .
  • This is in conjunction with the elements discussed above regarding FIG. 1 .
  • the essential elements of the light delivery system 14 , the collimating lens 16 , the polarizing beam splitter 22 , the adjustable telescope 30 , and the eye 40 have been shown.
  • the telescope 30 may be a cylindrical lens telescope or a pair of positive and negative lenses. Such a cylindrical lens configuration is shown in FIG. 8 , in which a pair of cylindrical lenses 132 , 134 is used in place of lenses 32 , 34 .
  • the spacing s between the lenses may be adjusted to increase or decrease power of the telescope.
  • the angle of the pair 120 , 122 is adjusted relative to the axis of the transmission path. This complicates the instrument, but provides for a better beam projected into the eye, requiring a wavefront sensor of only limited dynamic range, since both spherical and cylindrical aberrations would be subtracted from the wavefront, and only higher order terms would remain.
  • a high dynamic range wavefront sensor can be used. Since, in accordance with the present invention, only a small beam is injected into the eye, which will only pick up only a small wavefront aberration across its aperture, the focal spot on the eye will still be quite small, even with some astigmatism. Thus, cylindrical compensation is usually not needed. While some distortion will take place, it will be limited in size and an adequately small spot will still be realized.
  • a high dynamic range wavefront sensor corresponds to the use of a smaller focal length for the wavefront sensor lenslet array, as set forth in Equations (3) and (7). While the use of only spherical lenses will result in a loss of accuracy, the larger number of measurements afforded by the smaller lenslet array will sufficiently compensate for this degradation.
  • An alternative to using the telescope with a movable lens, as shown in FIG. 1 , for correcting base aberrations of the eye in the injected and reflected wavefront includes placing a corrective lens in front of the eye. If this lens is not a contact lens, it cannot be placed at the actual pupil plane of the eye, as shown in FIG. 9 , in which a corrective lens 35 is placed adjacent to the eye 40 . Thus, there will always be some magnification introduced by the combination of the refractive error of the eye and the correcting lens. Since it is difficult to set or know the vertex distance of the corrective lens, this magnification would be poorly known at best, and introduce error into the entire measurement.
  • a lens 37 in FIG. 7 may be from a trial lens kit, such as is commonly used for measuring a patient's manifest refraction, but is limited to the prescription accuracy.
  • the lens 37 in FIG. 7 may be a variable focal length lens, e.g., adaptive optics, liquid crystal displays, deformable mirrors.
  • the focal lengths of these elements may be controlled electronically, e.g., by the processor 68 shown in FIG. 1 , rather than by movement.
  • Either of these configurations is shown in FIG. 7 , in which the lens 37 may be a trial lens or a variable focal length lens.
  • the applicability of these configurations and the telescope configuration is shown in FIG. 4A-4C , in which the size of the spot in a myopic eye alone is shown in FIG. 4A , the size of the spot size with correction with a lens 37 is shown in FIG. 4B and the spot size with the adjustable telescope 30 is shown in FIG. 4C .
  • both configurations in FIGS. 4B and 4C result in the desired small spot size of the present invention.
  • a small focal spot can be created on the retina.
  • This small focal spot will concentrate light more, allowing the light to be divided into a larger number of focal spots.
  • Higher spatial resolution means that the assumption that each lenslet measures only tilt is valid over a much larger range.
  • Higher spatial resolution also leads to greater dynamic range and accuracy.
  • Higher dynamic range means that measurement of even high order terms of aberration can be accomplished accurately, without significant degradation of the measurement.

Abstract

An ophthalmic error measurement system includes a projecting optical system delivering light onto a retina of an eye, a pre-correction system which compensates a light beam to be injected into the eye for aberrations in the eye, the pre-correction system being positioned in between the projecting optical system and the eye, an imaging system which collects light scattered by the retina, and a detector receiving light returned by the retina from the imaging system. Use of the pre-correction system allows the end-to-end aberrations of the ocular system to be analyzed. The use of a pre-correction system also allows use of a minimized spot size on the retina, and all of its attendant advantages.

Description

    CROSS-REFERENCES TO RELATED APPLICATIONS
  • This application is a continuation of pending U.S. patent application Ser. No. 12/474,607 filed on 29 May 2009, which is a continuation of U.S. patent application Ser. No. 11/829,184 filed on 27 Jul. 2007, which issued on 30 Jun. 2009 as U.S. Pat. No. 7,553,022, which is a divisional of U.S. patent application Ser. No. 10/828,550, filed on 21 Apr. 2004, which issued on 25 Nov. 2008 as U.S. Pat. No. 7,455,407, which is in turn a continuation-in-part of U.S. patent application Ser. No. 10/369,513, filed on 21 Feb. 2003 and which issued on 21 Jun. 2005 as U.S. Pat. No. 6,908,196, and is also a continuation-in-part of U.S. patent application Ser. No. 10/419,072, filed on 21 Apr. 2003 which is in turn a continuation of U.S. patent application Ser. No. 09/692,483, filed on 20 Oct. 2000 and which issued on 22 Apr. 2003 as U.S. Pat. No. 6,550,917, which application in turn claims priority under 35 U.S.C. §119 from U.S. provisional patent application 60/182,088 filed on 11 Feb. 2000, the entire contents of each of which applications are hereby incorporated by reference in their entirety for all purposes as if fully set forth herein.
  • BACKGROUND OF THE INVENTION
  • 1. Field of the Invention
  • The present invention is directed to measurement of the refractive error in the eye, more particularly to methods and techniques for compiling a topographic mapping of these refractive errors.
  • 2. Description of Related Art
  • Measurements of aberrations in an eye are important for diagnosis of visual defects and assessment of acuity. These measurements and their accuracy become increasingly important in light of the growing number of ways, both surgical and non-surgical, that aberrations can be corrected. These corrections rely on accurate, precise measurements of the entire ocular system, allowing successful screening, treatment and follow-up. Enhancements in the accuracy of ocular measurements may aid in improving the identification of patients in need of correction and the performance of the correction itself.
  • There are a number of current methods used to measure performance of the ocular system. The most widely used and well established are psycho-physical methods, i.e., methods relying on subjective patient feedback. The oldest of the psycho-physical methods is the foreopter or trial lens method, which relies on trial and error to determine the required correction. There are psycho-physical methods for measuring visual acuity, ocular modulation transfer function, contrast sensitivity and other parameters of interest.
  • In addition to these subjective methods, there are also objective methods for assessing the performance of the ocular system. Such objective methods include corneal topography, wavefront aberrometry, corneal interferometry, and auto-refraction. Many of these methods only measure the contribution of specific elements to the total refractive error. For example, much work has been directed to measuring the topography of the cornea and characterizing the corneal layer. However, the corneal shape only contributes about 30-40% of the total refractive error in most cases. In order to measure the bulk of the refractive error and to provide a complete mapping for diagnosis and correction, additional information and measurements are needed.
  • Another method for determining the refraction of the eye is auto-refraction, which uses a variety of techniques to automatically determine the required corrective prescription. These automated techniques include projecting one or more spots or patterns onto the retina, automatically adjusting optical elements in the auto-refractor until the desired response is achieved, and determining the required correction from this adjustment. However, auto-refractors are not considered especially reliable. Further, auto-refractors measure only lower order components of the aberrations, e.g., focus and astigmatic errors.
  • Recently, the eye has started being considered as an optical system, leading to the application of methods previously used for other optical systems to the measurement of the eye. These methods include interferometry and Shack-Hartmann wavefront sensing. These techniques are of particular interest because they measure the complete aberrations of the eye. This additional information allows measurement of non-uniform, asymmetric errors that may be affecting vision. Further, this information may be linked with any of the various corrective techniques to provide improved vision. For example, U.S. Pat. No. 5,777,719 to Williams describes the application of Shack-Hartmann wavefront sensing and adaptive optics for correcting ocular aberrations to make a super-resolution retina-scope. U.S. Pat. No. 5,949,521 to Williams et al. describes using this information to make better contacts, intra-ocular lenses and other optical elements
  • Wavefront aberrometry measures the full, end-to-end aberrations through the entire optics of the eye. In these measurements, a spot is projected onto the retina, and the resulting returned light is measured with an optical system, thus obtaining a full, integrated, line-of-sight measurement of the eye=s aberrations. A key limitation of the instruments used in these measurements is the total resolution, which is ultimately limited by the lenslet array of the instrument. However, selection of the lenslet array is itself limited by several factors, most importantly the size of the spot projected onto the retina.
  • A schematic illustration of the basic elements of a two dimensional embodiment of a Shack-Hartmann wavefront sensor is shown in FIG. 2. A portion of an incoming wavefront 110 from the retina is incident on a two-dimensional lenslet array 112. The lenslet array 112 dissects the incoming wavefront 110 into a number of small samples. The smaller the lenslet, the higher the spatial resolution of the sensor. However, the spot size from small the lenslet, due to diffraction effects, limits the focal length that may be used, which in turn leads to lower sensitivity. Thus, these two parameters must be balanced in accordance with desired measurement performance.
  • Mathematically, the image on the detector plane 114 consists of a pattern of focal spots 116 with regular spacing d created with lenslets 112 of focal length f, as shown in FIG. 3. These spots must be distinct and separate, i.e., they must be readily identifiable. Thus, the spot size ρ cannot exceed ½ of the separation of the spots. The spot separation parameter NFR can be used to characterize the lenslet array 12 and is given by:
  • N FR = d ρ ( 1 )
  • The relationship between the size of a lens and the focal spot it creates, where λ is the wavelength of the light, is given by:
  • ρ = 1.22 f λ d ( 2 )
  • for a round lens or
  • ρ = f λ d ( 3 )
  • for a square lens. Thus, for a square lens, the separation parameter can be given by:
  • N FR = d 2 f λ ( 4 )
  • This is also known as the Fresnel number of the lenslet. To avoid overlapping focal spots, NFR>2. In practice, the Fresnel number must be somewhat greater than two to allow for a certain dynamic range of the instrument. The dynamic range of a Shack-Hartmann wavefront sensor can be defined as the limiting travel of the focal spot such that the edge of the spot just touches the projected lenslet boundary, given by:
  • θ max = d 2 - ρ f or ( 5 ) θ max = d 2 f - λ d = [ N FR 2 - 1 ] λ d ( 6 )
  • Thus, the dynamic range is directly proportional to the separation parameter and the lenslet size.
  • A particularly useful arrangement for a Shack-Hartmann wavefront sensor ocular measuring system places the lenslet array in an image relay optical system at a plane conjugate to the pupil or corneal surface. In this configuration, the spot size on the detector of the wavefront sensor is given by:
  • ρ 2 = 1 M f L f e ρ 1 ( 7 )
  • where M is the magnification of the imaging optics, fL is the focal length of the lenslet array, fe is the focal length of the eye and ρ1 is the spot size on the retina.
  • Comparing Equations (5) and (7), it is evident that the dynamic range of the wavefront sensor is limited by the size of the spot ρ1 projected on the retina. For a practical system, the dynamic range must be able to resolve errors in the optical systems. Thus, the dynamic range is a key limited parameter of the entire system design. In previous implementations of the Shack-Hartmann wavefront sensor used for ocular measurement, the dynamic range has been increased by increasing the size of each lenslet. However, the eye itself can have significant aberrations. Thus, any beam projected into the eye will become aberrated, spreading the focal spot and increasing the spot size ρ1 on the retina.
  • Various techniques have been implemented to address this problem. A small diameter beam has been used so that the total wavefront error is minimized across the injected beam. Another proposed solution projects the light into the eye at the focal point of a long focal length lens, operating as a field lens so that the size of the focal spot is not affected by the eye aberrations. In practice, for both of these cases, the beam is still somewhat large and is increased in size by the aberrations of the ocular system.
  • Another limitation on the dynamic range of the system is the sampling size. With a large spot on the retina, the sample size of the wavefront sensor must be increased to allow even a minimal dynamic range to be realized. For ocular systems with strong aberrations, such as found in people with large astigmatism or for those having undergone LASIK, the aberrations over each lenslet are sufficient to degrade the lenslet focal spot. Thus, the system is limited not just by focal spot overlap, but by the fact that the focal spots themselves fade out or are difficult to track. Using a small sample size does not allow sufficient light to be gathered, since the light is scattered by the retina into a large number of focal spots. Due to safety considerations, the input power may not be increased to compensate for this scattering.
  • SUMMARY OF THE INVENTION
  • The present invention is therefore directed to measurement of refractive errors of an eye that substantially overcomes one or more of the problems due to the limitations and disadvantages of measurements of the related art.
  • It is an object of the present invention to measure the end-to-end aberrations of the eye with sufficient accuracy and dynamic range in a practical manner.
  • It is a further object of the present invention to project a light beam into an ocular system so as to minimize the size of the focal spot on the retina.
  • It is another object of the present invention to use this smaller focal spot to allow much greater sampling density of the ocular system, thereby enhancing the accuracy and dynamic range.
  • It is yet another object of the present invention to make a practical, low cost system, available for use in a clinical setting.
  • At least one of the above and other objects may be realized by providing a system for measuring errors in an eye including a projecting optical system which delivers light onto a retina of the eye, a pre-correction system which compensates a light beam to be injected into the eye for aberrations in the eye, the pre-correction system being positioned in between the projecting optical system and the eye, an imaging system which collect light scattered by the retina, and a detector receiving light from the retina collected by the imaging system.
  • The detector may be a Shack-Hartmann wavefront sensor, a shearing interferometer, a Moiré deflectometer, or other passive phase measurement systems. The pre-correction system may include a telescope having at least one movable lens, fixed lenses inserted at an intermediate image plane, adaptive optical elements, and/or a cylindrical telescope. The pre-correction system may correct for focus and/or astigmatism errors in the eye. The telescope may be arranged so that a fixed lens of the telescope is one focal length away from the eye. Components used in the pre-correction system may also be used in the imaging system.
  • The pre-correction system may include a feedback loop which determines an appropriate pre-correction to be supplied by the pre-correction system. The feedback loop may include a detector receiving light returned from the retina, a processor comparing detected light with a desired feature of the light and adjusting at least one parameter of the pre-correction system in accordance with the comparison. The feedback loop may further include a return optical system for gathering the light from the retina. The return optical system may include the pre-correction system. The desired feature may be a minimized spot size on the retina.
  • The system may include an aperture that limits the angular dynamic range of the system. The system may further include a polarizing beam splitter between the eye and the wavefront sensor. The system may include an aligner that determines an appropriate eye alignment of the system. The projecting optical system may provide light to the eye at an angle to a central axis of the eye. The system may include an additional optical system between the detector and the eye. The system may include a power monitor which monitors power of the light beam being injected in the eye. The system may include an eye position detection system including a target projected on the eye, a position detector sensing the eye, and an adjustment system which adjusts a position of the system relative to the eye until the eye is in focus on the detector.
  • These and other objects of the present invention will become more readily apparent from the detailed description given hereinafter. However, it should be understood that the detailed description and specific examples, while indicating the preferred embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The foregoing and other objects, aspects and advantages will be described with reference to the drawings, in which:
  • FIG. 1 is a schematic top view of the measurement system of the present invention;
  • FIG. 2 is a schematic side view of the basic components of a Shack-Hartmann wavefront sensor;
  • FIG. 3 schematically illustrates the relationship between the size of the lens, its focal length and the spot size;
  • FIGS. 4A-4C schematically illustrate the spot size for different configurations;
  • FIGS. 5A-5B schematically illustrate off-axis injection of the light into the eye and the blocking of the reflected light from entering the wavefront sensor;
  • FIG. 6 is a schematic illustration of a configuration of the present invention using a fixed telescope and an adjustable telescope;
  • FIG. 7 is a schematic illustration of a configuration of the present invention using a variable lens;
  • FIG. 8 is a schematic illustration of a cylindrical telescope for use with the present invention; and
  • FIG. 9 is a schematic illustration of a configuration of the present invention using a corrective lens.
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • As noted above, the key to designing a practical ocular wavefront sensor system is how the light is injected into the eye. Since ocular refractive errors can be large, e.g., up to 20 diopters, the degradation of the injected beam can be significant. Further, it is difficult to design a wavefront sensor that has sufficient range to directly measure an extremely large refractive error. In accordance with the present invention, the spot projected on the ocular system is predistorted in a manner that compensates for the eye's fundamental aberrations. This allows the spot returned to the wavefront sensor to be well formed and minimally affected by the refractive errors. The small size of the spot allows small lenslets to be used while maintaining sufficient dynamic range to measure even large, high order aberrations. Since the light is tightly focused on the retina, the light is only scattered from a small region. When this small region is imaged onto the focal plane of the wavefront sensor, the light is concentrated onto a small group of pixels. Thus, even though the reflected light must be divided among a larger number of lenslets, each focal spot is brighter than in the conventional methods. Further, the greater sampling density leads to smaller wavefront aberrations across the aperture of each lenslet.
  • A system for such error measurement employing pre-compensation is shown in FIG. 1. The ocular wavefront measurement system shown therein generally includes a projection system for projecting light into the eye, a system for pre-correcting the injected light for ocular aberrations, a system for collecting light, a system for determining the pre-correction, and a system for measuring the collected light.
  • The projection system shown in FIG. 1 includes a light source 12, e.g., a laser, a laser diode, LED, or a super-luminescent diode, supplied to an optical fiber 14. For safety reasons, the light source is preferably a pulsed light source, is limited to a small power, is outside the normal visual detection range, e.g. infrared, and/or is directly collimated with an appropriate lens. The optical fiber may be a polarization maintaining fiber. The light leaving the optical fiber 14 is provided to a collimating lens 16. The use of an optical fiber 14 to deliver light from the light source 12 simplifies the collimating lens 16, since the fiber exit mode acts as a diffraction-limited point source. The collimating lens 16 is preferably rigidly mounted to the fiber 14. The collimated beam is then truncated to a desired size by an aperture 18. If needed, a polarizer 20 may be provided for polarizing the collimated beam. A polarizing beam splitter 22 directs the light from the projection system to the rest of the ocular measuring system.
  • Alternatively, the light source 12 may be provided alone, i.e., without the use of the fiber 14. The light from the light source 12 itself is then collimated by a collimating lens. While light sources used for ophthalmic measurement typically have a high degree of astigmatism, by using only a portion of the beam, e.g., 10-25%, typically from the center of the beam, the wavefront error over the beam is small enough that the beam size is substantially stable over the distance traversed in the ophthalmic measurement system. In other words, even though the beam is still astigmatic, the beam shape does not change while traversing the ophthalmic measurement system due to this astigmatism, so the astigmatism does not influence the measurement. The light may be polarized as required.
  • The light from the projection system is reflected by the polarizing beam splitter 22 and directed to a pre-compensation system, shown in FIG. 1 as a telescope 30. The telescope 30 includes lenses 32, 34 with an aperture 36 in between. The telescope 30 may be adjusted by moving the lenses relative to one another. This adjustment is to provide the desired pre-correction for the injected beam by adding defocus that just compensates for the spherical equivalent defocus of the ocular system being measured. The light from the telescope is directed by a beam splitter 38 to an ocular system 40 under measurement. The injected beam is focused by the ocular system 40 to a focal spot 42 on the retina of the ocular system 40. Light from this focal spot 42 is scattered or reflected by the retina.
  • The returned light is collected by the cornea and lens of the ocular system 40 and is approximately collimated. The beam splitter 38 directs the beam from the ocular system back to the telescope 30. The same position of the lenses 32, 34 of the telescope 30 corrects for the defocus aberrations of the ocular system 40 so that light arrives at a wavefront sensor 50 collimated to within the dynamic range of the sensor. The aperture 36 blocks any rays outside the angular dynamic range of the wavefront sensor 50 so that no mixing or measurement confusion occurs. When the wavefront sensor 50 is a Shack-Hartmann sensor, the focal spots cannot collide, interfere or cause confusion with adjacent focal spots. The light from the telescope now passes through the polarizing beam splitter 22, since the interaction with the retina will rotate the polarization of the light from the input polarization. The wavefront sensor 50 may be a Shack-Hartmann wavefront sensor, a shearing interferometer, a Moiré deflectometer or any other passive phase measurement sensor. When the wavefront sensor 50 is a Shack-Hartmann wavefront sensor, the wavefront sensor 50 includes the elements shown in FIG. 2.
  • The proper position of the lenses 32, 34 of the telescope 30 may be determined in a number of ways. In a preferred embodiment, an additional sensor 60 is used with a beam splitter 62 and a focusing lens 64 to create an image of the light incident upon the retina. The proper position of the lenses 32, 34 in the telescope 30 is determined by minimizing the spot size 42 on the back of the retina, performed by comparing the spot sizes from different positions of the lenses 32, 34 in the telescope 30. If the ocular system 40 is arranged to be one focal length of the objective lens 34 away from the lens 34, then the telescope 30 will be insensitive to changes in magnification or other errors. The wavefront sensor 50 should be arranged to be at the conjugate image plane to the ocular system 40. Preferably, the wavefront sensor 50, the retinal imaging sensor 60, the projection optics 16, 18, 20, the polarizing beam splitter 22, the beam splitter 62, and the focusing lens 64 are mounted on a platform 70 which is mounted in a moving stage 72. This allows the relative position of the telescope lenses 32, 34 to be varied while fixing the position of the remaining elements on the platform 70. The use of the optical fiber 14 allows the light source to be mounted off the platform 70, minimizing the mass of the elements moved by the translation stage 72. A processor 68 may be included to control movement of the translation stage 72 and to allow data processing, analysis and/or display.
  • As an additional safety measure, a small portion of the beam incident on beam splitter 38 is transmitted to a lens 44 which focuses the light onto a power monitor 46. The output of this power monitor 46 may be used to shut down the system if the power exceeds the safety limits of the system or to alter the power supplied to the light source 12 to reduce the power output by the light source in a known manner.
  • To measure the proper eye position relative to the measuring system, an additional detector 80 is included. Imaging optics 82 are designed such that the iris or cornea will be in focus for only a narrow region of space. A mirror 84 may be used to direct light onto the iris detector 80. The position of the system relative to the eye is adjusted until the iris or cornea is detected. The detection may be indicated to a user on an indicator 86. Preferably, this detection is used just during patient alignment and only uses a small percentage, e.g., less than 10% of the light.
  • To insure that the patient is viewing the correct line of sight, a target 90 is made visible through a beam splitter 94. The target 90 is imaged at infinity through a lens 92. The target position may be varied by moving the target relative to the lens 92 to present targets that are either in focus or slightly out-of-focus to minimize patient accommodation. Movement of the target 90 closer to the lens 92 stimulates near vision accommodation, allowing measurement of near vision visual acuity or the target may be arranged with the image past infinity to measure distance vision. The patient merely attempts to focus on the target. A light source behind the target is electronically controlled to adjust the target brightness and the position of the target is also electronically adjustable.
  • Thus, the telescope 30 is used to pre-compensate the injected light and to compensate for the returned wavefront to minimize the total wavefront error incident on the wavefront sensor. In the related art, telescopes have been used to relay image the light onto the wavefront sensor and to compensate for strong spherical and cylindrical aberrations, but the light was injected separately. This separate handling is due to strong back reflections that occur even for lenses having anti-reflection coatings thereon. Since the returned light from the retina may be very weak, even a small reflection from the lenses can quickly dominate the measurement and saturate the wavefront sensor 50. There are several ways of dealing with the problem. First, as shown in FIG. 1, polarized light and a polarizing beam splitter in conjunction with a quarter-wave plate may be used. Off axis parabolas or other curved mirrors may be used to direct the light to the telescope. The light may be injected off axis, so that any reflected light from the cornea is filtered out by the apertures of the system, as shown in FIGS. 5A and 5B. FIG. 5B illustrates how the light reflected by the cornea of the eye 40 is blocked by the aperture 36 from entering the wavefront sensor and influencing the measurement. The use of one or more of these schemes is sufficient to allow pre-compensation of the injected beam in accordance with the present invention without introducing unwanted reflections.
  • As an alternative, a second telescope may be used in conjunction with the first telescope to increase the dynamic range by providing an alternative location for the filtering aperture. Thus, one telescope can be completely fixed, while the other has a degree of freedom allowing movement until the lenses of the two telescopes are in contact. Such a configuration is shown in FIG. 6, in which a fixed telescope 51 with lenses 52, 54 and aperture 56, is used to supply light to the wavefront sensor 50. This is in conjunction with the elements discussed above regarding FIG. 1. For simplicity, only the essential elements of the light delivery system 14, the collimating lens 16, the polarizing beam splitter 22, the adjustable telescope 30, and the eye 40, have been shown.
  • Compensation of astigmatism of the ocular system and of the injected beam may be achieved in the following ways. The telescope 30 may be a cylindrical lens telescope or a pair of positive and negative lenses. Such a cylindrical lens configuration is shown in FIG. 8, in which a pair of cylindrical lenses 132, 134 is used in place of lenses 32, 34. The spacing s between the lenses may be adjusted to increase or decrease power of the telescope. The angle of the pair 120, 122 is adjusted relative to the axis of the transmission path. This complicates the instrument, but provides for a better beam projected into the eye, requiring a wavefront sensor of only limited dynamic range, since both spherical and cylindrical aberrations would be subtracted from the wavefront, and only higher order terms would remain.
  • Alternatively, a high dynamic range wavefront sensor can be used. Since, in accordance with the present invention, only a small beam is injected into the eye, which will only pick up only a small wavefront aberration across its aperture, the focal spot on the eye will still be quite small, even with some astigmatism. Thus, cylindrical compensation is usually not needed. While some distortion will take place, it will be limited in size and an adequately small spot will still be realized. A high dynamic range wavefront sensor corresponds to the use of a smaller focal length for the wavefront sensor lenslet array, as set forth in Equations (3) and (7). While the use of only spherical lenses will result in a loss of accuracy, the larger number of measurements afforded by the smaller lenslet array will sufficiently compensate for this degradation.
  • An alternative to using the telescope with a movable lens, as shown in FIG. 1, for correcting base aberrations of the eye in the injected and reflected wavefront includes placing a corrective lens in front of the eye. If this lens is not a contact lens, it cannot be placed at the actual pupil plane of the eye, as shown in FIG. 9, in which a corrective lens 35 is placed adjacent to the eye 40. Thus, there will always be some magnification introduced by the combination of the refractive error of the eye and the correcting lens. Since it is difficult to set or know the vertex distance of the corrective lens, this magnification would be poorly known at best, and introduce error into the entire measurement.
  • Another alternative includes using fixed or variable lenses. Ideally, these lenses are placed at an optical plane that is conjugate to the surface of the eye. Since it is also desirable for the wavefront sensor to be at this plane, a second telescope will need to be used in series with the first telescope. Further, since all of the lenses are fixed, some means will be needed for changing the various pre-corrector lenses in a known manner to achieve the proper result. A lens 37 in FIG. 7 may be from a trial lens kit, such as is commonly used for measuring a patient's manifest refraction, but is limited to the prescription accuracy. Alternatively, the lens 37 in FIG. 7 may be a variable focal length lens, e.g., adaptive optics, liquid crystal displays, deformable mirrors. The focal lengths of these elements may be controlled electronically, e.g., by the processor 68 shown in FIG. 1, rather than by movement. Either of these configurations is shown in FIG. 7, in which the lens 37 may be a trial lens or a variable focal length lens. The applicability of these configurations and the telescope configuration is shown in FIG. 4A-4C, in which the size of the spot in a myopic eye alone is shown in FIG. 4A, the size of the spot size with correction with a lens 37 is shown in FIG. 4B and the spot size with the adjustable telescope 30 is shown in FIG. 4C. As can be seen, both configurations in FIGS. 4B and 4C result in the desired small spot size of the present invention.
  • By pre-compensating for aberrations of the eye in the injected beam in accordance with the present invention, a small focal spot can be created on the retina. This small focal spot will concentrate light more, allowing the light to be divided into a larger number of focal spots. This, in turn, allows higher spatial resolution and the use of lower injected light power. Higher spatial resolution means that the assumption that each lenslet measures only tilt is valid over a much larger range. Higher spatial resolution also leads to greater dynamic range and accuracy. Higher dynamic range means that measurement of even high order terms of aberration can be accomplished accurately, without significant degradation of the measurement.
  • While the present invention is described herein with reference to illustrative embodiments for particular applications, it should be understood that the present invention is not limited thereto. Those having ordinary skill in the art and access to the teachings provided herein will recognize additional modifications, applications, and embodiments within the scope thereof and additional fields in which the invention would be of significant utility without undue experimentation. Thus, the scope of the invention should be determined by the appended claims and their legal equivalents, rather than by the examples given.

Claims (19)

1. A system for measuring errors in an eye, comprising:
a projecting optical system configured to focus light onto a retina of the eye;
an imaging system configured to receive light from the projecting optical system that is scattered by the retina;
a wavefront sensor configured to receive light returned by the retina from the imaging system; and
a target and a target optical system configured to project the target onto the eye so as to stimulate near vision accommodation of the eye.
2. The system of claim 1, wherein a relative distance between the target and the optical system is variable.
3. The system of claim 1, wherein the target is moveable relative to the target optical system.
4. The system of claim 1, further comprising a light source disposed behind the target, a brightness of the light source being electronically adjustable.
5. The system of claim 1, further comprising a pre-correction system configured to compensate a light beam to be injected into the eye for aberrations in the eye.
6. The system of claim 3, wherein the pre-correction system is positioned in between the projecting optical system and the eye.
7. The system of claim 1, wherein the system is configured to measure near vision visual acuity.
8. The method of claim 1, wherein the target optical system comprises a lens.
9. The method of claim 8, wherein the lens is a variable focal length lens.
10. A method of measuring optical characteristics of an eye, comprising:
providing a measurement system including:
a projecting optical system;
an imaging system for receiving light scattered by the retina;
a wavefront sensor; and
a target system comprising a target and a target optical system;
projecting the target onto the eye;
stimulating near vision accommodation of the eye;
directing light from the light source onto a retina of the eye;
receiving in the imaging system light scattered by the retina;
receiving in the wavefront sensor the light received by the imaging system; and
measuring a near vision visual acuity of the eye.
11. The method of claim 9, wherein stimulating near vision accommodation includes varying an optical distance between the target and the eye.
12. The method of claim 9, wherein stimulating near vision accommodation includes moving the target relative to the target optical system.
13. The method of claim 9, wherein the target optical system comprises a lens.
14. The method of claim 13, wherein the lens is a variable focal length lens.
15. A system for measuring errors in an eye, comprising:
a projecting optical system configured to focus light onto a retina of the eye;
an imaging system configured to receive light from the projecting optical system that is scattered by the retina;
a wavefront sensor configured to receive light returned by the retina from the imaging system;
a target and a target optical system configured to project an optical image of the target onto the eye;
wherein an optical distance between the target and the eye is variable so as to allow measurement of near vision visual acuity.
16. The system of claim 15, wherein the target is configured to stimulate near vision accommodation of the eye.
17. The system of claim 15, wherein the target is configured to be located so as to minimize accommodation of the eye.
18. The system of claim 15, wherein the target optical system comprises a lens.
19. The system of claim 18, wherein the lens is a variable focal length lens.
US12/611,438 2000-02-11 2009-11-03 Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement Abandoned US20100045934A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/611,438 US20100045934A1 (en) 2000-02-11 2009-11-03 Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US18208800P 2000-02-11 2000-02-11
US09/692,483 US6550917B1 (en) 2000-02-11 2000-10-20 Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement
US10/369,513 US6908196B2 (en) 2000-10-20 2003-02-21 System and method for performing optical corrective procedures with real-time feedback
US10/419,072 US20030193647A1 (en) 2000-02-11 2003-04-21 Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement
US10/828,550 US7455407B2 (en) 2000-02-11 2004-04-21 System and method of measuring and mapping three dimensional structures
US11/829,184 US7553022B2 (en) 2000-02-11 2007-07-27 System and method of measuring and mapping three dimensional structures
US12/474,607 US7988292B2 (en) 2000-02-11 2009-05-29 System and method of measuring and mapping three dimensional structures
US12/611,438 US20100045934A1 (en) 2000-02-11 2009-11-03 Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US12/474,607 Continuation US7988292B2 (en) 2000-02-11 2009-05-29 System and method of measuring and mapping three dimensional structures

Publications (1)

Publication Number Publication Date
US20100045934A1 true US20100045934A1 (en) 2010-02-25

Family

ID=33545514

Family Applications (4)

Application Number Title Priority Date Filing Date
US10/828,550 Expired - Fee Related US7455407B2 (en) 2000-02-11 2004-04-21 System and method of measuring and mapping three dimensional structures
US11/829,184 Expired - Fee Related US7553022B2 (en) 2000-02-11 2007-07-27 System and method of measuring and mapping three dimensional structures
US12/474,607 Expired - Fee Related US7988292B2 (en) 2000-02-11 2009-05-29 System and method of measuring and mapping three dimensional structures
US12/611,438 Abandoned US20100045934A1 (en) 2000-02-11 2009-11-03 Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement

Family Applications Before (3)

Application Number Title Priority Date Filing Date
US10/828,550 Expired - Fee Related US7455407B2 (en) 2000-02-11 2004-04-21 System and method of measuring and mapping three dimensional structures
US11/829,184 Expired - Fee Related US7553022B2 (en) 2000-02-11 2007-07-27 System and method of measuring and mapping three dimensional structures
US12/474,607 Expired - Fee Related US7988292B2 (en) 2000-02-11 2009-05-29 System and method of measuring and mapping three dimensional structures

Country Status (1)

Country Link
US (4) US7455407B2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120062708A1 (en) * 2010-09-15 2012-03-15 Ascentia Imaging, Inc. Imaging, Fabrication and Measurement Systems and Methods
DE102013000295A1 (en) * 2013-01-09 2014-07-10 Rodenstock Gmbh Apparatus and method for determining a set of ophthalmic data
US9534884B2 (en) 2012-01-03 2017-01-03 Ascentia Imaging, Inc. Coded localization systems, methods and apparatus
US9739864B2 (en) 2012-01-03 2017-08-22 Ascentia Imaging, Inc. Optical guidance systems and methods using mutually distinct signal-modifying
US20180160899A1 (en) * 2016-12-14 2018-06-14 Ovitz Corporation Devices and Methods for Refractive Power Measurements of an Eye with Reduced Errors
US10126114B2 (en) 2015-05-21 2018-11-13 Ascentia Imaging, Inc. Angular localization system, associated repositionable mechanical structure, and associated method
US10132925B2 (en) 2010-09-15 2018-11-20 Ascentia Imaging, Inc. Imaging, fabrication and measurement systems and methods

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7455407B2 (en) * 2000-02-11 2008-11-25 Amo Wavefront Sciences, Llc System and method of measuring and mapping three dimensional structures
US20030060878A1 (en) 2001-08-31 2003-03-27 Shadduck John H. Intraocular lens system and method for power adjustment
US6634552B2 (en) * 2001-09-26 2003-10-21 Nec Laboratories America, Inc. Three dimensional vision device and method, and structured light bar-code patterns for use in the same
US8048155B2 (en) 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
US20050021139A1 (en) * 2003-02-03 2005-01-27 Shadduck John H. Ophthalmic devices, methods of use and methods of fabrication
US10835373B2 (en) 2002-12-12 2020-11-17 Alcon Inc. Accommodating intraocular lenses and methods of use
US7217288B2 (en) 2002-12-12 2007-05-15 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
US8328869B2 (en) 2002-12-12 2012-12-11 Powervision, Inc. Accommodating intraocular lenses and methods of use
US8361145B2 (en) 2002-12-12 2013-01-29 Powervision, Inc. Accommodating intraocular lens system having circumferential haptic support and method
EP1599748A4 (en) 2003-03-06 2007-10-24 John H Shadduck Adaptive optic lens and method of making
US7303582B2 (en) * 2003-03-21 2007-12-04 Advanced Medical Optics, Inc. Foldable angle-fixated intraocular lens
US7556378B1 (en) 2003-04-10 2009-07-07 Tsontcho Ianchulev Intraoperative estimation of intraocular lens power
CA2561388C (en) 2004-04-20 2017-10-10 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US9872763B2 (en) 2004-10-22 2018-01-23 Powervision, Inc. Accommodating intraocular lenses
US7187431B2 (en) * 2004-11-16 2007-03-06 Asml Netherlands B.V. Lithographic apparatus, method of determining properties thereof and computer program
JP2008544295A (en) * 2005-06-28 2008-12-04 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Method for reconstructing the surface topology of an object
DE102005040749B3 (en) * 2005-08-26 2007-01-25 Heraeus Quarzglas Gmbh & Co. Kg Method for the interferometric measurement of an optical property of a test region of a blank made from a transparent material comprises completely covering the test region with a film made from an immersion fluid
AU2007235239B2 (en) * 2006-04-07 2013-01-17 Amo Wavefront Sciences, Llc Geometric measurement system and method of measuring a geometric characteristic of an object
EP2079356B1 (en) 2006-07-10 2012-12-26 AMO Manufacturing USA, LLC Systems and methods for wavefront analysis over circular and noncircular pupils
US20080100850A1 (en) * 2006-10-31 2008-05-01 Mitutoyo Corporation Surface height and focus sensor
US7728961B2 (en) * 2006-10-31 2010-06-01 Mitutoyo Coporation Surface height and focus sensor
US7993398B2 (en) * 2007-04-24 2011-08-09 Abbott Medical Optics Inc. Angle indicator for capsular bag size measurement
US8314927B2 (en) * 2007-07-23 2012-11-20 Powervision, Inc. Systems and methods for testing intraocular lenses
CA2696450C (en) 2007-07-23 2016-02-16 Terah Whiting Smiley Lens delivery system
EP2671541B1 (en) 2007-07-23 2019-04-17 PowerVision, Inc. Accommodating intraocular lenses
US8668734B2 (en) 2010-07-09 2014-03-11 Powervision, Inc. Intraocular lens delivery devices and methods of use
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
US9610155B2 (en) 2008-07-23 2017-04-04 Powervision, Inc. Intraocular lens loading systems and methods of use
JP5752415B2 (en) 2007-07-23 2015-07-22 パワーヴィジョン・インコーポレーテッド Correction of the refractive power of the lens after implantation
US8974526B2 (en) 2007-08-27 2015-03-10 Amo Groningen B.V. Multizonal lens with extended depth of focus
US9216080B2 (en) 2007-08-27 2015-12-22 Amo Groningen B.V. Toric lens with decreased sensitivity to cylinder power and rotation and method of using the same
US7594729B2 (en) 2007-10-31 2009-09-29 Wf Systems, Llc Wavefront sensor
US7723657B2 (en) * 2007-11-16 2010-05-25 Mitutoyo Corporation Focus detection apparatus having extended detection range
US7880897B2 (en) * 2007-12-28 2011-02-01 Fujinon Corporation Light wave interferometer apparatus
ATE523810T1 (en) 2008-02-15 2011-09-15 Amo Regional Holdings SYSTEM, GLASS LENS AND METHOD FOR EXPANDING THE DEPTH OF FOCUS
US8439498B2 (en) 2008-02-21 2013-05-14 Abbott Medical Optics Inc. Toric intraocular lens with modified power characteristics
EP2268191B1 (en) 2008-03-28 2013-03-20 Abbott Medical Optics Inc. Systems for ocular measurements
US8862447B2 (en) 2010-04-30 2014-10-14 Amo Groningen B.V. Apparatus, system and method for predictive modeling to design, evaluate and optimize ophthalmic lenses
EP2341869B1 (en) 2008-09-29 2015-05-27 SIFI MEDTECH S.r.l. Systems for designing and implanting a customized biometric intraocular lens
WO2010054268A2 (en) 2008-11-06 2010-05-14 Wavetec Vision Systems, Inc. Optical angular measurement system for ophthalmic applications and method for positioning of a toric intraocular lens with increased accuracy
US7988293B2 (en) * 2008-11-14 2011-08-02 AMO Wavefront Sciences LLC. Method of qualifying light spots for optical measurements and measurement instrument employing method of qualifying light spots
US10299913B2 (en) 2009-01-09 2019-05-28 Powervision, Inc. Accommodating intraocular lenses and methods of use
JP5312100B2 (en) * 2009-03-03 2013-10-09 キヤノン株式会社 Measuring method and measuring device
US8876290B2 (en) 2009-07-06 2014-11-04 Wavetec Vision Systems, Inc. Objective quality metric for ocular wavefront measurements
WO2011008609A1 (en) 2009-07-14 2011-01-20 Wavetec Vision Systems, Inc. Ophthalmic surgery measurement system
WO2011008606A1 (en) 2009-07-14 2011-01-20 Wavetec Vision Systems, Inc. Determination of the effective lens position of an intraocular lens using aphakic refractive power
WO2011026068A2 (en) * 2009-08-31 2011-03-03 Powervision, Inc. Lens capsule size estimation
US8436630B2 (en) * 2009-10-14 2013-05-07 Gooch And Housego Plc Corrected optical spectral responses for photoelectric devices
EP3824846A1 (en) 2009-12-18 2021-05-26 AMO Groningen B.V. Limited echelette lens
US8900298B2 (en) 2010-02-23 2014-12-02 Powervision, Inc. Fluid for accommodating intraocular lenses
CN101881607A (en) * 2010-06-10 2010-11-10 上海理工大学 Planar error detection system
EP3330776A1 (en) 2010-12-01 2018-06-06 AMO Groningen B.V. A multifocal lens having an optical add power progression, and a system and method of providing same
US8623081B2 (en) 2010-12-15 2014-01-07 Amo Groningen B.V. Apparatus, system, and method for intraocular lens power calculation using a regression formula incorporating corneal spherical aberration
US10456026B2 (en) 2010-12-15 2019-10-29 Amo Wavefront Sciences, Llc Apparatus, system, and method for intraocular lens power calculation using a regression formula incorporating corneal spherical aberration
US10500092B2 (en) 2010-12-30 2019-12-10 Amo Wavefront Sciences, Llc Treatment planning method and system for controlling laser refractive surgery
US10582846B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
US10582847B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
US10583039B2 (en) 2010-12-30 2020-03-10 Amo Wavefront Sciences, Llc Method and system for eye measurements and cataract surgery planning using vector function derived from prior surgeries
JP5751886B2 (en) * 2011-03-30 2015-07-22 キヤノン株式会社 Surface shape measuring device and surface shape measuring method
US8622546B2 (en) 2011-06-08 2014-01-07 Amo Wavefront Sciences, Llc Method of locating valid light spots for optical measurement and optical measurement instrument employing method of locating valid light spots
US9182289B2 (en) 2011-10-14 2015-11-10 Canon Kabushiki Kaisha Apparatus and method for estimating wavefront parameters
US10433949B2 (en) 2011-11-08 2019-10-08 Powervision, Inc. Accommodating intraocular lenses
CA2861046A1 (en) 2012-01-10 2013-07-18 Digitalvision, Llc A refractometer with a remote wavefront generator
CA2861061A1 (en) 2012-01-10 2013-07-18 Digitalvision, Llc Intra-ocular lens optimizer
FR2985811B1 (en) * 2012-01-13 2014-12-05 Cassidian Test & Services OPTICAL DEVICE, OPTICAL TEST BENCH AND OPTICAL TEST METHOD.
US9063002B2 (en) * 2012-01-20 2015-06-23 California Institute Of Technology Broadband, common-path, interferometric wavefront sensor
TWI588560B (en) 2012-04-05 2017-06-21 布萊恩荷登視覺協會 Lenses, devices, methods and systems for refractive error
US9072462B2 (en) 2012-09-27 2015-07-07 Wavetec Vision Systems, Inc. Geometric optical power measurement device
US9201250B2 (en) 2012-10-17 2015-12-01 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
CN104768499B (en) 2012-10-17 2017-06-23 华柏恩视觉研究中心 For ametropic eyeglass, device, method and system
CA2877203A1 (en) 2012-12-04 2014-06-12 Amo Groningen B.V. Lenses, systems and methods for providing binocular customized treatments to correct presbyopia
US10028654B2 (en) 2013-03-15 2018-07-24 Amo Development, Llc System and method for eye orientation
EP2967842B1 (en) 2013-03-15 2020-11-04 Alcon Inc. Method of reconfiguring an intraocular lens for delivery to a delivery device
US20160054195A1 (en) 2014-08-20 2016-02-25 Johnson & Johnson Vision Care, Inc. System and methods for measuring ophthalmic lens
DE102015110456B4 (en) * 2015-06-29 2017-02-09 Hochschule Für Technik Und Wirtschaft Des Saarlandes Purkinememeter and method for automatic evaluation
AU2015404164A1 (en) 2015-07-27 2018-01-18 Amo Wavefront Sciences, Llc Optical imaging and measurement systems and methods for cataract surgery and treatment planning
EP3370647B8 (en) 2015-11-06 2021-06-30 Alcon Inc. Accommodating intraocular lenses and methods of manufacturing
CN106254858B (en) * 2015-12-31 2018-05-04 北京智谷睿拓技术服务有限公司 Light field display control method and device, light field display device
CN106254857B (en) * 2015-12-31 2018-05-04 北京智谷睿拓技术服务有限公司 Light field display control method and device, light field display device
CN106254753B (en) * 2015-12-31 2019-03-12 北京智谷睿拓技术服务有限公司 Light field display control method and device, light field show equipment
CN106375694B (en) * 2015-12-31 2019-04-23 北京智谷睿拓技术服务有限公司 Light field display control method and device, light field show equipment
AU2017218681B2 (en) 2016-02-09 2021-09-23 Amo Groningen B.V. Progressive power intraocular lens, and methods of use and manufacture
AU2017237095B2 (en) 2016-03-23 2022-08-04 Johnson & Johnson Surgical Vision, Inc. Ophthalmic apparatus with corrective meridians having extended tolerance band
US10649234B2 (en) 2016-03-23 2020-05-12 Johnson & Johnson Surgical Vision, Inc. Ophthalmic apparatus with corrective meridians having extended tolerance band
AU2017248672B2 (en) 2016-04-13 2021-10-14 Amo Development, Llc Apparatus, system, and method for intraocular lens power calculation using a regression formula incorporating corneal spherical aberration
DE102016210966A1 (en) 2016-06-20 2017-12-21 Micro-Epsilon Optronic Gmbh Method and device for measuring a curved wavefront with at least one wavefront sensor
WO2018078439A2 (en) 2016-10-25 2018-05-03 Amo Groningen B.V. Realistic eye models to design and evaluate intraocular lenses for a large field of view
US10739227B2 (en) 2017-03-23 2020-08-11 Johnson & Johnson Surgical Vision, Inc. Methods and systems for measuring image quality
CN107727232B (en) * 2017-10-24 2023-07-04 中国科学院上海技术物理研究所 Geometric registration testing device and method
CA3082053A1 (en) 2017-11-30 2019-06-06 Amo Groningen B.V. Intraocular lenses that improve post-surgical spectacle independent and methods of manufacturing thereof
JP6843778B2 (en) 2018-01-15 2021-03-17 株式会社東芝 Object surface inspection device
US11231375B2 (en) 2019-05-20 2022-01-25 Wisconsin Alumni Research Foundation Apparatus for high-speed surface relief measurement
TWI727381B (en) * 2019-07-26 2021-05-11 合盈光電科技股份有限公司 Coaxial multi-wavelength optical element detection system
EP4041131A4 (en) 2019-10-04 2023-11-15 Alcon Inc. Adjustable intraocular lenses and methods of post-operatively adjusting intraocular lenses
US11886046B2 (en) 2019-12-30 2024-01-30 Amo Groningen B.V. Multi-region refractive lenses for vision treatment
CN113933265B (en) * 2021-09-27 2023-01-03 中国科学院长春光学精密机械与物理研究所 Speckle measuring device and measurement analysis method
CN114252243B (en) * 2021-12-10 2023-09-19 中国科学院光电技术研究所 Detection device and method for micro cylindrical lens array

Citations (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819256A (en) * 1972-08-11 1974-06-25 H Borough Apparatus for refracting the eye
US4021102A (en) * 1973-11-26 1977-05-03 Kabushiki Kaisha Hoya Lens Auto-refractometer
US4725138A (en) * 1985-05-22 1988-02-16 Adaptive Optics Associates Incorporated Optical wavefront sensing system
US5048935A (en) * 1986-12-24 1991-09-17 Hughes Aircraft Company Method for adaptive correction of the phase non-uniformity of a liquid crystal light valve
US5136413A (en) * 1990-11-05 1992-08-04 Litel Instruments Imaging and illumination system with aspherization and aberration correction by phase steps
US5258791A (en) * 1990-07-24 1993-11-02 General Electric Company Spatially resolved objective autorefractometer
US5493391A (en) * 1994-07-11 1996-02-20 Sandia Corporation One dimensional wavefront distortion sensor comprising a lens array system
US5617157A (en) * 1994-06-15 1997-04-01 Metaphase Ophthalmic Corp. Computer controlled subjective refractor
US5777719A (en) * 1996-12-23 1998-07-07 University Of Rochester Method and apparatus for improving vision and the resolution of retinal images
US5929970A (en) * 1997-05-13 1999-07-27 Kabushiki Kaisha Topcon Optical characteristic measuring apparatus
US5936720A (en) * 1996-07-10 1999-08-10 Neal; Daniel R. Beam characterization by wavefront sensor
US5978053A (en) * 1995-07-07 1999-11-02 New Mexico State University Technology Transfer Corporation Characterization of collimation and beam alignment
US5991102A (en) * 1994-11-25 1999-11-23 Asahi Kogaku Kogyo Kabushiki Kaisha Beam protecting device
US6007204A (en) * 1998-06-03 1999-12-28 Welch Allyn, Inc. Compact ocular measuring system
US6042233A (en) * 1997-11-11 2000-03-28 Kabushiki Kaisha Topcon Optical characteristic measuring apparatus
US6052180A (en) * 1996-07-10 2000-04-18 Wavefront Sciences, Inc. Apparatus and method for characterizing pulsed light beams
US6086204A (en) * 1999-09-20 2000-07-11 Magnante; Peter C. Methods and devices to design and fabricate surfaces on contact lenses and on corneal tissue that correct the eye's optical aberrations
US6130419A (en) * 1996-07-10 2000-10-10 Wavefront Sciences, Inc. Fixed mount wavefront sensor
US6199986B1 (en) * 1999-10-21 2001-03-13 University Of Rochester Rapid, automatic measurement of the eye's wave aberration
US6234978B1 (en) * 1997-02-12 2001-05-22 Kabushiki Kaisha Topcon Optical characteristic measuring apparatus
US6270221B1 (en) * 1998-08-19 2001-08-07 Alcon Universal Ltd. Apparatus and method for measuring vision defects of a human eye
US6271915B1 (en) * 1996-11-25 2001-08-07 Autonomous Technologies Corporation Objective measurement and correction of optical systems using wavefront analysis
US6382795B1 (en) * 2000-05-20 2002-05-07 Carl Zeiss, Inc. Method and apparatus for measuring refractive errors of an eye
US6394605B1 (en) * 2001-05-23 2002-05-28 Alcon Universal Ltd. Fogging method for a wavefront sensor
US6452145B1 (en) * 2000-01-27 2002-09-17 Aoptix Technologies, Inc. Method and apparatus for wavefront sensing
US6547395B1 (en) * 1998-02-06 2003-04-15 Wavefront Sciences, Inc. Methods of measuring moving objects and reducing exposure during wavefront measurements
US6550917B1 (en) * 2000-02-11 2003-04-22 Wavefront Sciences, Inc. Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement
US20050219460A1 (en) * 1999-07-02 2005-10-06 E-Vision, Llc System, apparatus, and method for correcting vision using an electro-active lens
US7419264B1 (en) * 2003-11-07 2008-09-02 Kestrel Corporation Ophthalmic aberrometer for measuring aberrations in the eye

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3204876C2 (en) 1982-02-12 1986-10-16 Helmut Dr.rer.nat. 8000 München Krueger Device for determining the refraction state of the human eye
US5071245A (en) 1988-12-06 1991-12-10 Kabushiki Kaisha Topcon Ocular refracting power measuring system
DE4222395A1 (en) 1992-07-08 1994-01-13 Amtech Ges Fuer Angewandte Mic Optical system for measuring refraction of eye with light source - has variable imaging optics adjustable in its power of refraction focussing light emanating from light source on retina of eye
JP3219534B2 (en) 1993-04-16 2001-10-15 キヤノン株式会社 Optical device
DE19950792A1 (en) 1999-10-21 2001-04-26 Technolas Gmbh Ophthalmic wavefront aberration diagnostic tool, has camera that aids in focusing aerial image from lenslet array, on wavefront sensor
US7455407B2 (en) * 2000-02-11 2008-11-25 Amo Wavefront Sciences, Llc System and method of measuring and mapping three dimensional structures
WO2001078585A2 (en) 2000-04-19 2001-10-25 Alcon Universal Ltd. Wavefront sensor for objective measurement of an optical system and associated methods
AR030419A1 (en) 2000-04-25 2003-08-20 Alcon Inc METHOD AND PROVISION TO IMPROVE THE QUALITY OF SENSOR IMAGE DATA FROM A WAVE FRONT THAT EMERGE FROM AN EYE

Patent Citations (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819256A (en) * 1972-08-11 1974-06-25 H Borough Apparatus for refracting the eye
US4021102A (en) * 1973-11-26 1977-05-03 Kabushiki Kaisha Hoya Lens Auto-refractometer
US4725138A (en) * 1985-05-22 1988-02-16 Adaptive Optics Associates Incorporated Optical wavefront sensing system
US5048935A (en) * 1986-12-24 1991-09-17 Hughes Aircraft Company Method for adaptive correction of the phase non-uniformity of a liquid crystal light valve
US5258791A (en) * 1990-07-24 1993-11-02 General Electric Company Spatially resolved objective autorefractometer
US5136413A (en) * 1990-11-05 1992-08-04 Litel Instruments Imaging and illumination system with aspherization and aberration correction by phase steps
US5617157A (en) * 1994-06-15 1997-04-01 Metaphase Ophthalmic Corp. Computer controlled subjective refractor
US5493391A (en) * 1994-07-11 1996-02-20 Sandia Corporation One dimensional wavefront distortion sensor comprising a lens array system
US5991102A (en) * 1994-11-25 1999-11-23 Asahi Kogaku Kogyo Kabushiki Kaisha Beam protecting device
US5978053A (en) * 1995-07-07 1999-11-02 New Mexico State University Technology Transfer Corporation Characterization of collimation and beam alignment
US6130419A (en) * 1996-07-10 2000-10-10 Wavefront Sciences, Inc. Fixed mount wavefront sensor
US5936720A (en) * 1996-07-10 1999-08-10 Neal; Daniel R. Beam characterization by wavefront sensor
US6052180A (en) * 1996-07-10 2000-04-18 Wavefront Sciences, Inc. Apparatus and method for characterizing pulsed light beams
US6271914B1 (en) * 1996-11-25 2001-08-07 Autonomous Technologies Corporation Objective measurement and correction of optical systems using wavefront analysis
US6271915B1 (en) * 1996-11-25 2001-08-07 Autonomous Technologies Corporation Objective measurement and correction of optical systems using wavefront analysis
US6095651A (en) * 1996-12-23 2000-08-01 University Of Rochester Method and apparatus for improving vision and the resolution of retinal images
US5777719A (en) * 1996-12-23 1998-07-07 University Of Rochester Method and apparatus for improving vision and the resolution of retinal images
US6234978B1 (en) * 1997-02-12 2001-05-22 Kabushiki Kaisha Topcon Optical characteristic measuring apparatus
US5929970A (en) * 1997-05-13 1999-07-27 Kabushiki Kaisha Topcon Optical characteristic measuring apparatus
US6042233A (en) * 1997-11-11 2000-03-28 Kabushiki Kaisha Topcon Optical characteristic measuring apparatus
US6547395B1 (en) * 1998-02-06 2003-04-15 Wavefront Sciences, Inc. Methods of measuring moving objects and reducing exposure during wavefront measurements
US6007204A (en) * 1998-06-03 1999-12-28 Welch Allyn, Inc. Compact ocular measuring system
US6270221B1 (en) * 1998-08-19 2001-08-07 Alcon Universal Ltd. Apparatus and method for measuring vision defects of a human eye
US20050219460A1 (en) * 1999-07-02 2005-10-06 E-Vision, Llc System, apparatus, and method for correcting vision using an electro-active lens
US6086204A (en) * 1999-09-20 2000-07-11 Magnante; Peter C. Methods and devices to design and fabricate surfaces on contact lenses and on corneal tissue that correct the eye's optical aberrations
US6299311B1 (en) * 1999-10-21 2001-10-09 University Of Rochester Rapid, automatic measurement of the eye's wave aberration
US6199986B1 (en) * 1999-10-21 2001-03-13 University Of Rochester Rapid, automatic measurement of the eye's wave aberration
US6452145B1 (en) * 2000-01-27 2002-09-17 Aoptix Technologies, Inc. Method and apparatus for wavefront sensing
US6550917B1 (en) * 2000-02-11 2003-04-22 Wavefront Sciences, Inc. Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement
US6382795B1 (en) * 2000-05-20 2002-05-07 Carl Zeiss, Inc. Method and apparatus for measuring refractive errors of an eye
US6394605B1 (en) * 2001-05-23 2002-05-28 Alcon Universal Ltd. Fogging method for a wavefront sensor
US7419264B1 (en) * 2003-11-07 2008-09-02 Kestrel Corporation Ophthalmic aberrometer for measuring aberrations in the eye

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10132925B2 (en) 2010-09-15 2018-11-20 Ascentia Imaging, Inc. Imaging, fabrication and measurement systems and methods
US9212899B2 (en) * 2010-09-15 2015-12-15 Ascentia Imaging, Inc. Imaging, fabrication and measurement systems and methods
US20120062708A1 (en) * 2010-09-15 2012-03-15 Ascentia Imaging, Inc. Imaging, Fabrication and Measurement Systems and Methods
US9534884B2 (en) 2012-01-03 2017-01-03 Ascentia Imaging, Inc. Coded localization systems, methods and apparatus
US9739864B2 (en) 2012-01-03 2017-08-22 Ascentia Imaging, Inc. Optical guidance systems and methods using mutually distinct signal-modifying
US11499816B2 (en) 2012-01-03 2022-11-15 Ascentia Imaging, Inc. Coded localization systems, methods and apparatus
US11092662B2 (en) 2012-01-03 2021-08-17 Ascentia Imaging, Inc. Optical guidance systems and methods using mutually distinct signal-modifying sensors
US10024651B2 (en) 2012-01-03 2018-07-17 Ascentia Imaging, Inc. Coded localization systems, methods and apparatus
DE102013000295A1 (en) * 2013-01-09 2014-07-10 Rodenstock Gmbh Apparatus and method for determining a set of ophthalmic data
DE102013000295B4 (en) * 2013-01-09 2014-09-04 Rodenstock Gmbh Apparatus and method for determining a set of ophthalmic data
US10126114B2 (en) 2015-05-21 2018-11-13 Ascentia Imaging, Inc. Angular localization system, associated repositionable mechanical structure, and associated method
WO2018111625A1 (en) * 2016-12-14 2018-06-21 Ovitz Corporation Devices and methods for refractive power measurements of an eye with reduced errors
US20180160899A1 (en) * 2016-12-14 2018-06-14 Ovitz Corporation Devices and Methods for Refractive Power Measurements of an Eye with Reduced Errors

Also Published As

Publication number Publication date
US20080018910A1 (en) 2008-01-24
US20040263783A1 (en) 2004-12-30
US7553022B2 (en) 2009-06-30
US20090284753A1 (en) 2009-11-19
US7455407B2 (en) 2008-11-25
US7988292B2 (en) 2011-08-02

Similar Documents

Publication Publication Date Title
EP1255483B1 (en) Dynamic range extension techniques for a wave-front sensor
US20100045934A1 (en) Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement
CA2338060C (en) Apparatus and method for measuring vision defects of a human eye
US7891812B2 (en) Aberrometer provided with a visual acuity testing system
US7036934B1 (en) Wavefront sensor having multi-power modes, independent adjustment camera, and accommodation range measurement
US6598975B2 (en) Apparatus and method for measuring vision defects of a human eye
KR101668372B1 (en) A large diopter range real time sequential wavefront sensor
US6271914B1 (en) Objective measurement and correction of optical systems using wavefront analysis
US6439720B1 (en) Method and apparatus for measuring optical aberrations of the human eye
US7044603B2 (en) Compact portable wavefront sensor
US6273566B1 (en) Ophthalmologic characteristic measuring apparatus
US20090161090A1 (en) Systems and Methods for Measuring the Shape and Location of an object
MXPA01012938A (en) Wavefront sensor for objective measurement of an optical system and associated methods.
MXPA01013364A (en) Spatial filter for enhancing hartmann shack images and associated methods.
US9462939B2 (en) Objective phoropter system
JP2004159784A (en) Ocular characteristic measuring apparatus
US7213919B2 (en) Method and device for calibrating an optical wavefront system
US20020063849A1 (en) Eye characteristic measuring apparatus
Beverage Measuring refractive error in the human eye using a Shack-Hartmann-based autorefractor

Legal Events

Date Code Title Description
STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION